Structure summary for 12E8

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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2E8 Fab Fragment

ItemInfo
PDB code: 12e8
Organism: MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
In complex: False
Fvs present: 2
Light chain type: Kappa
PDB has constant region: True

This PDB has 2 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain H
Light Chain L
Heavy V / J / C subgroups IGHV14 / IGHJ3 / IGHG1
Light V / J / C subgroups IGKV6 / IGKJ5 / IGKC
Bound-state Unbound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Bound-state Unbound

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH H Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLQQSGAE
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
VVRSGASVKL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCTASGFNIK
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
DYYIHWVKQR
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PEKGLEWIGW
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
IDPEIGDTEY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
VPKFQGKATM
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
TADTSSNTAY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQLSSLTSED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCNAGH
H97 H98 H99 H100 H100AH100BH100CH101 H102 H103
DYDRGRFPYW
H104 H105 H106 H107 H108 H109 H110 H111 H112 H113
GQGTLVTVSA
VL L Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
DIVMTQSQKF
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
MSTSVGDRVS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ITCKASQNVG
L31 L32 L33 L34 L35 L36 L37 L38 L39 L40
TAVAWYQQKP
L41 L42 L43 L44 L45 L46 L47 L48 L49 L50
GQSPKLMIYS
L51 L52 L53 L54 L55 L56 L57 L58 L59 L60
ASNRYTGVPD
L61 L62 L63 L64 L65 L66 L67 L68 L69 L70
RFTGSGSGTD
L71 L72 L73 L74 L75 L76 L77 L78 L79 L80
FTLTISNMQS
L81 L82 L83 L84 L85 L86 L87 L88 L89 L90
EDLADYFCQQ
L91 L92 L93 L94 L95 L96 L97 L98 L99 L100
YSSYPLTFGA
L101 L102 L103 L104 L105 L106 L107 L108 L109
GTKLELKRA

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
H/LGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 KASQNVGTAVA
CDRL2 SASNRYT
CDRL3 QQYSSYPLT
CDRH1 GFNIKDY
CDRH2 DPEIGD
CDRH3 GHDYDRGRFPY
VH-VL orientation:
(see plot)
AngleValue
HL -71.0°
HC1 69.2°
HC2 106.5°
LC1 118.6°
LC2 74.6°
dc 16.1 Å
Fab Details:
ItemInfo
Heavy Chain P
Light Chain M
Heavy V / J / C subgroups IGHV14 / IGHJ3 / IGHG1
Light V / J / C subgroups IGKV6 / IGKJ5 / IGKC
Bound-state Unbound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Bound-state Unbound

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH P Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLQQSGAE
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
VVRSGASVKL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCTASGFNIK
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
DYYIHWVKQR
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PEKGLEWIGW
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
IDPEIGDTEY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
VPKFQGKATM
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
TADTSSNTAY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQLSSLTSED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCNAGH
H97 H98 H99 H100 H100AH100BH100CH101 H102 H103
DYDRGRFPYW
H104 H105 H106 H107 H108 H109 H110 H111 H112 H113
GQGTLVTVSA
VL M Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
DIVMTQSQKF
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
MSTSVGDRVS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ITCKASQNVG
L31 L32 L33 L34 L35 L36 L37 L38 L39 L40
TAVAWYQQKP
L41 L42 L43 L44 L45 L46 L47 L48 L49 L50
GQSPKLMIYS
L51 L52 L53 L54 L55 L56 L57 L58 L59 L60
ASNRYTGVPD
L61 L62 L63 L64 L65 L66 L67 L68 L69 L70
RFTGSGSGTD
L71 L72 L73 L74 L75 L76 L77 L78 L79 L80
FTLTISNMQS
L81 L82 L83 L84 L85 L86 L87 L88 L89 L90
EDLADYFCQQ
L91 L92 L93 L94 L95 L96 L97 L98 L99 L100
YSSYPLTFGA
L101 L102 L103 L104 L105 L106 L107 L108 L109
GTKLELKRA

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
P/MGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 KASQNVGTAVA
CDRL2 SASNRYT
CDRL3 QQYSSYPLT
CDRH1 GFNIKDY
CDRH2 DPEIGD
CDRH3 GHDYDRGRFPY
VH-VL orientation:
(see plot)
AngleValue
HL -62.4°
HC1 74.1°
HC2 113.2°
LC1 118.8°
LC2 81.6°
dc 15.9 Å

Downloads and links.

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Chothia structureDownload
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Entry in IMGTSee the IMGT entry
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