Structure summary for 1ETZ

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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The Three-Dimensional Structure Of An Anti-Sweetener Fab, Nc10.14, Shows The Extent Of Structural Diversity In Antigen Recognition By Immunoglobulins

ItemInfo
PDB code: 1etz
Organism: MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 2
Binding affinity (KD): 7.3e-08 M
ΔG: -9.73 kcal/mol
Affinity method: Other
Source: Paper Link
Light chain type: Lambda
PDB has constant region: True

This PDB has 2 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain B
Light Chain A
Heavy V / J / C subgroups IGHV8 / IGHJ2 / IGHG2B
Light V / J / C subgroups IGLV1 / IGLJ1 / IGLC1
Bound-state Bound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain B
Type Hapten
Name ?

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH B Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
QVTLKESGPG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
ILQPSQTLSL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
TCSFSGFSLS
H31 H31AH31BH32 H33 H34 H35 H36 H37 H38
TSGMGVGWIR
H39 H40 H41 H42 H43 H44 H45 H46 H47 H48
QPSGEGLEWL
H49 H50 H51 H52 H53 H54 H55 H56 H57 H58
ADIWWNDKKY
H59 H60 H61 H62 H63 H64 H65 H66 H67 H68
YNPSLKSRLT
H69 H70 H71 H72 H73 H74 H75 H76 H77 H78
VSKDTSSNQV
H79 H80 H81 H82 H82AH82BH82CH83 H84 H85
FLKITSVDTS
H86 H87 H88 H89 H90 H91 H92 H93 H94 H95
DTATYHCARR
H96 H97 H98 H99 H100 H100AH100BH100CH100DH100E
TFSYYYGSSF
H100FH100GH100HH101 H102 H103 H104 H105 H106 H107
YYFDNWGQGT
H108 H109 H110 H111 H112 H113
TLTVSS
VL A Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L11
FAVVTQESAL
L12 L13 L14 L15 L16 L17 L18 L19 L20 L21
TTSPGETVTL
L22 L23 L24 L25 L26 L27 L28 L29 L30 L30A
TCRSSTGAVT
L30BL30CL31 L32 L33 L34 L35 L36 L37 L38
TSNYAIWVQE
L39 L40 L41 L42 L43 L44 L45 L46 L47 L48
KPDHLFSGLI
L49 L50 L51 L52 L53 L54 L55 L56 L57 L58
GGTNNRVPGV
L59 L60 L61 L62 L63 L64 L65 L66 L67 L68
PARFSGSLIG
L69 L70 L71 L72 L73 L74 L75 L76 L77 L78
DKAALTVTGA
L79 L80 L81 L82 L83 L84 L85 L86 L87 L88
QTEDEAIYFC
L89 L90 L91 L92 L93 L94 L95 L96 L97 L98
ALWYSNHWVF
L99 L100 L101 L102 L103 L104 L105 L106 L106AL107
GGGTKLTVLG
L108 L109
QP
Antigen typeOn chain idStructure
Hapten B

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
B/AGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSTGAVTTSNYAI
CDRL2 GTNNRVP
CDRL3 ALWYSNHWV
CDRH1 GFSLSTSGM
CDRH2 WWNDK
CDRH3 RTFSYYYGSSFYYFDN
VH-VL orientation:
(see plot)
AngleValue
HL -61.2°
HC1 67.2°
HC2 121.1°
LC1 115.4°
LC2 85.1°
dc 16.2 Å
Fab Details:
ItemInfo
Heavy Chain H
Light Chain L
Heavy V / J / C subgroups IGHV8 / IGHJ2 / IGHG2B
Light V / J / C subgroups IGLV1 / IGLJ1 / IGLC1
Bound-state Bound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain H
Type Hapten
Name ?

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH H Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
QVTLKESGPG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
ILQPSQTLSL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
TCSFSGFSLS
H31 H31AH31BH32 H33 H34 H35 H36 H37 H38
TSGMGVGWIR
H39 H40 H41 H42 H43 H44 H45 H46 H47 H48
QPSGEGLEWL
H49 H50 H51 H52 H53 H54 H55 H56 H57 H58
ADIWWNDKKY
H59 H60 H61 H62 H63 H64 H65 H66 H67 H68
YNPSLKSRLT
H69 H70 H71 H72 H73 H74 H75 H76 H77 H78
VSKDTSSNQV
H79 H80 H81 H82 H82AH82BH82CH83 H84 H85
FLKITSVDTS
H86 H87 H88 H89 H90 H91 H92 H93 H94 H95
DTATYHCARR
H96 H97 H98 H99 H100 H100AH100BH100CH100DH100E
TFSYYYGSSF
H100FH100GH100HH101 H102 H103 H104 H105 H106 H107
YYFDNWGQGT
H108 H109 H110 H111 H112 H113
TLTVSS
VL L Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L11
FAVVTQESAL
L12 L13 L14 L15 L16 L17 L18 L19 L20 L21
TTSPGETVTL
L22 L23 L24 L25 L26 L27 L28 L29 L30 L30A
TCRSSTGAVT
L30BL30CL31 L32 L33 L34 L35 L36 L37 L38
TSNYAIWVQE
L39 L40 L41 L42 L43 L44 L45 L46 L47 L48
KPDHLFSGLI
L49 L50 L51 L52 L53 L54 L55 L56 L57 L58
GGTNNRVPGV
L59 L60 L61 L62 L63 L64 L65 L66 L67 L68
PARFSGSLIG
L69 L70 L71 L72 L73 L74 L75 L76 L77 L78
DKAALTVTGA
L79 L80 L81 L82 L83 L84 L85 L86 L87 L88
QTEDEAIYFC
L89 L90 L91 L92 L93 L94 L95 L96 L97 L98
ALWYSNHWVF
L99 L100 L101 L102 L103 L104 L105 L106 L106AL107
GGGTKLTVLG
L108 L109
QP
Antigen typeOn chain idStructure
Hapten H

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
H/LGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSTGAVTTSNYAI
CDRL2 GTNNRVP
CDRL3 ALWYSNHWV
CDRH1 GFSLSTSGM
CDRH2 WWNDK
CDRH3 RTFSYYYGSSFYYFDN
VH-VL orientation:
(see plot)
AngleValue
HL -60.7°
HC1 67.2°
HC2 121.3°
LC1 116.2°
LC2 86.2°
dc 16.1 Å

Downloads and links.

ItemDownload link
Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
Flag misannotation