Structure summary for 1FL6

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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The Hapten Complexed Germline Precursor To Sulfide Oxidase Catalytic Antibody 28B4

ItemInfo
PDB code: 1fl6
Organism: CHIMERIC HOMO SAPIENS/MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 2
Binding affinity (KD): 2.5e-05 M
ΔG: None kcal/mol
Affinity method: SPR
Source: Paper Link
Light chain type: Kappa
PDB has constant region: True

This PDB has 2 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain B
Light Chain A
Heavy V / J / C subgroups IGHV3 / IGHJ6 / IGHG1
Light V / J / C subgroups IGKV1 / IGKJ1 / IGKC
Bound-state Bound
Species CHIMERIC HOMO SAPIENS/MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain B
Type Hapten
Name ?

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH B Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
QVQLVESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCATSGFTFT
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
DYYMSWVRQP
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKALEWLGF
H51 H52 H52AH52BH52CH53 H54 H55 H56 H57
IRNKANGYTT
H58 H59 H60 H61 H62 H63 H64 H65 H66 H67
EYSASVKGRF
H68 H69 H70 H71 H72 H73 H74 H75 H76 H77
TISRDNSQSI
H78 H79 H80 H81 H82 H82AH82BH82CH83 H84
LYLQMNTLRA
H85 H86 H87 H88 H89 H90 H91 H92 H93 H94
EDSATYYCAR
H95 H96 H97 H98 H99 H100 H101 H102 H103 H104
DGSYAMDYWG
H105 H106 H107 H108 H109 H110 H111 H112 H113
QGTSVTVSS
VL A Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
ELVMTQTPLS
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
LPVSLGDQAS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ISCRSSQSIV
L30AL30BL30CL30DL30EL31 L32 L33 L34 L35
HSNGNTYLEW
L36 L37 L38 L39 L40 L41 L42 L43 L44 L45
YLQKPGQSPK
L46 L47 L48 L49 L50 L51 L52 L53 L54 L55
LLIYKVSNRF
L56 L57 L58 L59 L60 L61 L62 L63 L64 L65
SGVPDRFSGS
L66 L67 L68 L69 L70 L71 L72 L73 L74 L75
GSGTDFTLKI
L76 L77 L78 L79 L80 L81 L82 L83 L84 L85
SRVEAEDLGV
L86 L87 L88 L89 L90 L91 L92 L93 L94 L95
YYCFQGSHVP
L96 L97 L98 L99 L100 L101 L102 L103 L104 L105
RTFGGGTKLE
L106 L107 L108 L109 L110
IKRTV
Antigen typeOn chain idStructure
Hapten B

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
B/AGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSQSIVHSNGNTYLE
CDRL2 KVSNRFS
CDRL3 FQGSHVPRT
CDRH1 GFTFTDY
CDRH2 RNKANGYT
CDRH3 DGSYAMDY
VH-VL orientation:
(see plot)
AngleValue
HL -55.6°
HC1 69.2°
HC2 121.3°
LC1 122.7°
LC2 83.5°
dc 16.5 Å
Fab Details:
ItemInfo
Heavy Chain H
Light Chain L
Heavy V / J / C subgroups IGHV3 / IGHJ6 / IGHG1
Light V / J / C subgroups IGKV1 / IGKJ1 / IGKC
Bound-state Bound
Species CHIMERIC HOMO SAPIENS/MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain H
Type Hapten
Name ?

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH H Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
QVQLVESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCATSGFTFT
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
DYYMSWVRQP
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKALEWLGF
H51 H52 H52AH52BH52CH53 H54 H55 H56 H57
IRNKANGYTT
H58 H59 H60 H61 H62 H63 H64 H65 H66 H67
EYSASVKGRF
H68 H69 H70 H71 H72 H73 H74 H75 H76 H77
TISRDNSQSI
H78 H79 H80 H81 H82 H82AH82BH82CH83 H84
LYLQMNTLRA
H85 H86 H87 H88 H89 H90 H91 H92 H93 H94
EDSATYYCAR
H95 H96 H97 H98 H99 H100 H101 H102 H103 H104
DGSYAMDYWG
H105 H106 H107 H108 H109 H110 H111 H112 H113
QGTSVTVSS
VL L Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
ELVMTQTPLS
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
LPVSLGDQAS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ISCRSSQSIV
L30AL30BL30CL30DL30EL31 L32 L33 L34 L35
HSNGNTYLEW
L36 L37 L38 L39 L40 L41 L42 L43 L44 L45
YLQKPGQSPK
L46 L47 L48 L49 L50 L51 L52 L53 L54 L55
LLIYKVSNRF
L56 L57 L58 L59 L60 L61 L62 L63 L64 L65
SGVPDRFSGS
L66 L67 L68 L69 L70 L71 L72 L73 L74 L75
GSGTDFTLKI
L76 L77 L78 L79 L80 L81 L82 L83 L84 L85
SRVEAEDLGV
L86 L87 L88 L89 L90 L91 L92 L93 L94 L95
YYCFQGSHVP
L96 L97 L98 L99 L100 L101 L102 L103 L104 L105
RTFGGGTKLE
L106 L107 L108 L109 L110
IKRTV
Antigen typeOn chain idStructure
Hapten H

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
H/LGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSQSIVHSNGNTYLE
CDRL2 KVSNRFS
CDRL3 FQGSHVPRT
CDRH1 GFTFTDY
CDRH2 RNKANGYT
CDRH3 DGSYAMDY
VH-VL orientation:
(see plot)
AngleValue
HL -55.8°
HC1 69.5°
HC2 121.2°
LC1 122.4°
LC2 83.2°
dc 16.3 Å

Downloads and links.

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Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
Flag misannotation