1NMA

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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Structure information

N9 Neuraminidase Complexes With Antibodies Nc41 And Nc10: Empirical Free-Energy Calculations Capture Specificity Trends Observed With Mutant Binding Data

Item	Info
PDB code:	1nma
Organism:	MUS MUSCULUS
Experimental method:	X-RAY DIFFRACTION
In complex:	True
Fvs present:	1
Binding affinity (KD):	1.4e-08 M
ΔG:	-10.8 kcal/mol
Affinity method:	Other
Source:	Paper Link
Light chain type:	Kappa
PDB has constant region:	False

Paired chains information

This PDB has 1 antibody variable fragment(s)

H / L

Fab Details:

Item	Info
Heavy Chain	H
Light Chain	L
Heavy V / J subgroups	IGHV1 / IGHJ2
Light V / J subgroups	IGKV10 / IGKJ2
Bound-state	Bound
Species	MUS MUSCULUS
ScFv?	False
Constant domains present?	False

Antigen Details:

Item	Info
Chain	N
Type	protein
Name	n9 neuraminidase
Species	INFLUENZA A VIRUS

Sequence:

Chothia-numbered antibody sequences

Chain type

Chain id

Fasta sequence

Chothia annotated sequence ( framework / CDRs )

VH

H

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H1	H2	H3	H4	H5	H6	H7	H8	H9	H10
E	V	Q	L	Q	Q	P	G	A	E

H11	H12	H13	H14	H15	H16	H17	H18	H19	H20
L	V	K	P	G	A	S	V	R	M

H21	H22	H23	H24	H25	H26	H27	H28	H29	H30
S	C	K	A	S	G	Y	T	F	T

H31	H32	H33	H34	H35	H36	H37	H38	H39	H40
N	Y	N	M	Y	W	V	K	Q	S

H41	H42	H43	H44	H45	H46	H47	H48	H49	H50
P	G	Q	G	L	E	W	I	G	I

H51	H52	H52A	H53	H54	H55	H56	H57	H58	H59
F	Y	P	G	N	G	D	T	S	Y

H60	H61	H62	H63	H64	H65	H66	H67	H68	H69
N	Q	K	F	K	D	K	A	T	L

H70	H71	H72	H73	H74	H75	H76	H77	H78	H79
T	A	D	K	S	S	N	T	A	Y

H80	H81	H82	H82A	H82B	H82C	H83	H84	H85	H86
M	Q	L	S	S	L	T	S	E	D

H87	H88	H89	H90	H91	H92	H93	H94	H95	H96
S	A	V	Y	Y	C	A	R	S	G

H97	H98	H99	H100	H100A	H100B	H100C	H100D	H100E	H101
G	S	Y	R	Y	D	G	G	F	D

H102	H103	H104	H105	H106	H107	H108	H109	H110	H111
Y	W	G	Q	G	T	T	L	T	V

H112	H113
S	S

VL

L

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L1	L2	L3	L4	L5	L6	L7	L8	L9	L10
D	I	Q	M	T	Q	T	T	S	S

L11	L12	L13	L14	L15	L16	L17	L18	L19	L20
L	S	A	S	L	G	D	R	V	T

L21	L22	L23	L24	L25	L26	L27	L28	L29	L30
I	S	C	R	A	S	Q	D	I	S

L31	L32	L33	L34	L35	L36	L37	L38	L39	L40
N	Y	L	N	W	Y	Q	Q	N	P

L41	L42	L43	L44	L45	L46	L47	L48	L49	L50
D	G	T	V	K	L	L	I	Y	Y

L51	L52	L53	L54	L55	L56	L57	L58	L59	L60
T	S	N	L	H	S	E	V	P	S

L61	L62	L63	L64	L65	L66	L67	L68	L69	L70
R	F	S	G	S	G	S	G	T	D

L71	L72	L73	L74	L75	L76	L77	L78	L79	L80
Y	S	L	T	I	S	N	L	E	Q

L81	L82	L83	L84	L85	L86	L87	L88	L89	L90
E	D	I	A	T	Y	F	C	Q	Q

L91	L92	L93	L94	L95	L96	L97	L98	L99	L100
D	F	T	L	P	F	T	F	G	G

L101	L102	L103	L104	L105	L106	L107	L108	L109
G	T	K	L	E	I	R	R	A

Antigen sequence

Antigen type	Chain id	Fasta sequence	Sequence (Clustal colouring)
protein	N	Download	R E F N N L T K G L C T I N S W H I Y G K D N A V R I G E D S D V L V T R E P Y V S C D P D E C R F Y A L S Q G T T I R G K H S N G T I H D R S Q Y R D L I S W P L S S P P T V Y N S R V E C I G W S S T S C H D G R A R M S I C I S G P N N N A S A V I W Y N R R P V T E I N T W A R N I L R T Q E S E C V C Q N G V C P V V F T D G S A T G P A E T R I Y Y F K E G K I L K W E P L T G T A K H I E E C S C Y G E Q A G V T C T C R D N W Q G S N R P V I Q I D P V A M T H T S Q Y I C S P V L T D N P R P N D P T V G K C N D P Y P G N N N N G V K G F S Y L D G G N T W L G R T I S I A S R S G Y E M L K V P N A L T D D K S R P T Q G Q T I V L N T D W S G Y S G S F M D Y W A E G E C Y R A C F Y V E L I R G R P K E D K V W W T S N S I V S M C S S T E F L G Q W N W P D G A K I E Y F L

Antibody i-Patch annotation:

Fab heavy/lightchain	Link to the Antibody i-Patch annotation (What is this?)
H/L	Get AB i-Patch annotation

Chothia CDR information:

CDR	Sequence
CDRL1	RASQDISNYLN
CDRL2	YTSNLHS
CDRL3	QQDFTLPFT
CDRH1	GYTFTNY
CDRH2	YPGNGD
CDRH3	SGGSYRYDGGFDY

VH-VL orientation:
(see plot)

Angle	Value
HL	-61.0°
HC1	72.5°
HC2	109.9°
LC1	120.3°
LC2	81.6°
dc	16.4 Å

Downloads

Downloads and links.

Item	Download link
Full structure	Download
Chothia structure	Download
Summary file	Download
Entry in the PDB	See the file on the PDB
Entry in IMGT	See the IMGT entry

Structure summary for 1NMA

Details of structure 1NMA

Structure visualisation for 1NMA

Structure information

Paired chains information

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