2P42

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

Display options:
Spacefill model
Wire model
Ball&stick model
Cartoon model
Color atom number
Color by structure
Isosurface vdw: on off
Spin: on off

Structure information

Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 1.8A Resolution: Se3-Mono-2 Crystal Form With Three Se-Met Sites (M34, M51, M83) In Vhh Scaffold

Item	Info
PDB code:	2p42
Organism:	CAMELUS DROMEDARIUS
Experimental method:	X-RAY DIFFRACTION
In complex:	True
Fvs present:	2
Binding affinity (KD):	2.3e-08 M
ΔG:	-10.59 kcal/mol
Affinity method:	Other
Temperature:	30 °C
Source:	Paper Link
Light chain type:	NA
PDB has constant region:	False

Paired chains information

This PDB has 2 antibody variable fragment(s)

B / -

Fab Details:

Item	Info
Heavy Chain	B
Light Chain	-
Heavy V / J subgroups	IGHV1 / IGHJ4
Light subgroup
Bound-state	Bound
Species	CAMELUS DROMEDARIUS
ScFv?	False
Constant domains present?	False

Antigen Details:

Item	Info
Chain	A
Type	protein
Name	ribonuclease pancreatic
Species	BOS TAURUS

Sequence:

Chothia-numbered antibody sequences

Chain type

Chain id

Fasta sequence

Chothia annotated sequence ( framework / CDRs )

VH

B

Download

H1	H2	H3	H4	H5	H6	H7	H8	H9	H10
Q	V	Q	L	V	E	S	G	G	G

H11	H12	H13	H14	H15	H16	H17	H18	H19	H20
L	V	Q	A	G	G	S	L	R	L

H21	H22	H23	H24	H25	H26	H27	H28	H29	H30
S	C	A	A	S	G	Y	A	Y	T

H31	H32	H33	H34	H35	H36	H37	H38	H39	H40
Y	I	Y	M	G	W	F	R	Q	A

H41	H42	H43	H44	H45	H46	H47	H48	H49	H50
P	G	K	E	R	E	G	V	A	A

H51	H52	H52A	H53	H54	H55	H56	H57	H58	H59
M	D	S	G	G	G	G	T	L	Y

H60	H61	H62	H63	H64	H65	H66	H67	H68	H69
A	D	S	V	K	G	R	F	T	I

H70	H71	H72	H73	H74	H75	H76	H77	H78	H79
S	R	D	K	G	K	N	T	V	Y

H80	H81	H82	H82A	H82B	H82C	H83	H84	H85	H86
L	Q	M	D	S	L	K	P	E	D

H87	H88	H89	H90	H91	H92	H93	H94	H95	H96
T	A	T	Y	Y	C	A	A	G	G

H97	H98	H99	H100	H100A	H100B	H100C	H100D	H101	H102
Y	E	L	R	D	R	T	Y	G	Q

H103	H104	H105	H106	H107	H108	H109	H110	H111	H112
W	G	Q	G	T	Q	V	T	V	S

H113
S

Antigen sequence

Antigen type	Chain id	Fasta sequence	Sequence (Clustal colouring)
protein	A	Download	K E T A A A K F E R Q H M D S S T S A A S S S N Y C N Q M M K S R N L T K D R C K P V N T F V H E S L A D V Q A V C S Q K N V A C K N G Q T N C Y Q S Y S T M S I T D C R E T G S S K Y P N C A Y K T T Q A N K H I I V A C E G N P Y V P V H F D A S V

Antibody i-Patch annotation:

Fab heavy/lightchain	Link to the Antibody i-Patch annotation (What is this?)
B/-	Get AB i-Patch annotation

Chothia CDR information:

CDR	Sequence
CDRH1	GYAYTYI
CDRH2	DSGGGG
CDRH3	GGYELRDRTYGQ

D / -