Structure summary for 2VYR

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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Structure Of Human Mdm4 N-Terminal Domain Bound To A Single Domain Antibody

ItemInfo
PDB code: 2vyr
Organism: HOMO SAPIENS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 8
Binding affinity (KD): 4.4e-08 M
ΔG: -9.69 kcal/mol
Affinity method: ITC
Temperature: 15 °C
Source: Paper Link
Light chain type: NA
PDB has constant region: False

This PDB has 8 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain E
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Antigen Details:
ItemInfo
Chain A
Type protein
Name mdm4 protein
Species HOMO SAPIENS

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH E Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
protein A Download
A C R I S P G Q I N Q V R P K L P L L K I L H A A G A Q G E
M F T V K E V M H Y L G Q Y I M V K Q L Y D Q Q E Q H M V Y
C G G D L L G E L L G R Q S F S V K D P S P L Y D M L R K N
L V T L A T A T T D A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
E/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain F
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Antigen Details:
ItemInfo
Chain B
Type protein
Name mdm4 protein
Species HOMO SAPIENS

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH F Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
protein B Download
A C R I S P G Q I N Q V R P K L P L L K I L H A A G A Q G E
M F T V K E V M H Y L G Q Y I M V K Q L Y D Q Q E Q H M V Y
C G G D L L G E L L G R Q S F S V K D P S P L Y D M L R K N
L V T L A T A T T D A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
F/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain G
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Antigen Details:
ItemInfo
Chain C
Type protein
Name mdm4 protein
Species HOMO SAPIENS

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH G Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
protein C Download
A C R I S P G Q I N Q V R P K L P L L K I L H A A G A Q G E
M F T V K E V M H Y L G Q Y I M V K Q L Y D Q Q E Q H M V Y
C G G D L L G E L L G R Q S F S V K D P S P L Y D M L R K N
L V T L A T A T T D A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
G/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain H
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Antigen Details:
ItemInfo
Chain D
Type protein
Name mdm4 protein
Species HOMO SAPIENS

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH H Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
protein D Download
A C R I S P G Q I N Q V R P K L P L L K I L H A A G A Q G E
M F T V K E V M H Y L G Q Y I M V K Q L Y D Q Q E Q H M V Y
C G G D L L G E L L G R Q S F S V K D P S P L Y D M L R K N
L V T L A T A T T D A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
H/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain I
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Unbound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Bound-state Unbound

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH I Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
I/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain J
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Antigen Details:
ItemInfo
Chain A
Type protein
Name mdm4 protein
Species HOMO SAPIENS

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH J Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
protein A Download
A C R I S P G Q I N Q V R P K L P L L K I L H A A G A Q G E
M F T V K E V M H Y L G Q Y I M V K Q L Y D Q Q E Q H M V Y
C G G D L L G E L L G R Q S F S V K D P S P L Y D M L R K N
L V T L A T A T T D A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
J/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain K
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Unbound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Bound-state Unbound

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH K Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
K/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY
Fab Details:
ItemInfo
Heavy Chain L
Light Chain -
Heavy V / J subgroups IGHV3 / IGHJ4
Light subgroup
Bound-state Unbound
Species HOMO SAPIENS
ScFv? False
Constant domains present? False
Bound-state Unbound

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH L Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLLESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSLRL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCAASGFTFE
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
EYAMLWVRQA
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PGKGLEWVSG
H51 H52 H52AH53 H54 H55 H56 H57 H58 H59
INARGYTTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
ADSVKGRFTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SRDNSKNTLY
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LQMNSLRTED
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAKPW
H97 H98 H99 H100 H100AH100BH100CH100DH100EH100F
YPFMASKGSE
H100GH101 H102 H103 H104 H105 H106 H107 H108 H109
FDYWGQGTLV
H110 H111 H112 H113
TVSS

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
L/-Get AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRH1 GFTFEEY
CDRH2 NARGYT
CDRH3 PWYPFMASKGSEFDY

Downloads and links.

ItemDownload link
Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
Flag misannotation