Structure summary for 2XZC

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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Crystal Structure Of Phosphonate-Modified Recombinant A.17 Antibody Fab Fragment

ItemInfo
PDB code: 2xzc
Organism: HOMO SAPIENS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 1
Binding affinity (KD): 2.3e-06 M
ΔG: -7.67 kcal/mol
Affinity method: ITC
Temperature: 25 °C
Source: Paper Link
Light chain type: Lambda
PDB has constant region: True

This PDB has 1 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain H
Light Chain L
Heavy V / J / C subgroups IGHV4 / IGHJ1 / IGHG1
Light V / J / C subgroups IGLV1 / IGKJ4 / IGKC
Bound-state Bound
Species HOMO SAPIENS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain L
Type Hapten
Name 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH H Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVQLQESGPG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVKPSETLSL
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
TCAVSGYSIS
H31 H31AH32 H33 H34 H35 H36 H37 H38 H39
SGYYWGWIRQ
H40 H41 H42 H43 H44 H45 H46 H47 H48 H49
PPGKGLEWIG
H50 H51 H52 H53 H54 H55 H56 H57 H58 H59
SIYHSGSTYY
H60 H61 H62 H63 H64 H65 H66 H67 H68 H69
NPSLKSRVTI
H70 H71 H72 H73 H74 H75 H76 H77 H78 H79
SVDTSKNQFS
H80 H81 H82 H82AH82BH82CH83 H84 H85 H86
LKLSSVTAAD
H87 H88 H89 H90 H91 H92 H93 H94 H95 H96
TAVYYCAGLT
H97 H98 H99 H100 H100AH100BH101 H102 H103 H104
QSSHNDANWG
H105 H106 H107 H108 H109 H110 H111 H112 H113
QGTLTTVSS
VL L Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L11
ESVLTQPPSV
L12 L13 L14 L15 L16 L17 L18 L19 L20 L21
SAAPGQKVTI
L22 L23 L24 L25 L26 L27 L28 L29 L30 L30A
SCSGSSSNIG
L30BL31 L32 L33 L34 L35 L36 L37 L38 L39
NNYVSWYQQL
L40 L41 L42 L43 L44 L45 L46 L47 L48 L49
PGTAPKLLIY
L50 L51 L52 L53 L54 L55 L56 L57 L58 L59
DNNKRPSGIP
L60 L61 L62 L63 L64 L65 L66 L67 L68 L69
DRFSGSKSGT
L70 L71 L72 L73 L74 L75 L76 L77 L78 L79
SATLGITGLQ
L80 L81 L82 L83 L84 L85 L86 L87 L88 L89
TGDEADYYCG
L90 L91 L92 L93 L94 L95 L95AL96 L97 L98
TWDSSLNPVF
L99 L100 L101 L102 L103 L104 L105 L106 L107 L108
GGGTKLEIKR
L109 L110
TV
Antigen typeOn chain idStructure
Hapten L

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
H/LGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 SGSSSNIGNNYVS
CDRL2 DNNKRPS
CDRL3 GTWDSSLNPV
CDRH1 GYSISSGY
CDRH2 YHSGS
CDRH3 LTQSSHNDAN
VH-VL orientation:
(see plot)
AngleValue
HL -64.3°
HC1 75.2°
HC2 119.7°
LC1 119.0°
LC2 80.7°
dc 16.0 Å

Downloads and links.

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Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
Flag misannotation