Structure summary for 2Z92

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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Crystal Structure Of The Fab Fragment Of Anti-Ciguatoxin Antibody 10C9 In Complex With Ctx3C_Abcde

ItemInfo
PDB code: 2z92
Organism: MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 1
Binding affinity (KD): 1.11e-08 M
ΔG: -10.85 kcal/mol
Affinity method: ITC
Temperature: 25 °C
Source: Paper Link
Light chain type: Kappa
PDB has constant region: True

This PDB has 1 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain A
Light Chain B
Heavy V / J / C subgroups IGHV3 / IGHJ2 / IGHG1
Light V / J / C subgroups IGKV4 / IGKJ5 / IGKC
Bound-state Bound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
On chain A
Type Hapten
Name (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH A Download
H3 H4 H5 H6 H7 H8 H9 H10 H11 H12
QLLESGPDLV
H13 H14 H15 H16 H17 H18 H19 H20 H21 H22
KPSQSLSLTC
H23 H24 H25 H26 H27 H28 H29 H30 H31 H31A
TVTGYSITSG
H32 H33 H34 H35 H36 H37 H38 H39 H40 H41
YNWHWIRQFP
H42 H43 H44 H45 H46 H47 H48 H49 H50 H51
GNKLEWMGYI
H52 H53 H54 H55 H56 H57 H58 H59 H60 H61
HYRGTTNYNT
H62 H63 H64 H65 H66 H67 H68 H69 H70 H71
SLKSRISITR
H72 H73 H74 H75 H76 H77 H78 H79 H80 H81
DSSKNQFFLQ
H82 H82AH82BH82CH83 H84 H85 H86 H87 H88
LNSVTTEDTA
H89 H90 H91 H92 H93 H94 H95 H96 H97 H98
TYYCACDDFY
H99 H101 H102 H103 H104 H105 H106 H107 H108 H109
SDYWGQGTIV
H110 H111 H112 H113
TVSS
VL B Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
ELVMTQTPAI
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
MSASPGEKVT
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
MTCSASSSVS
L32 L33 L34 L35 L36 L37 L38 L39 L40 L41
SVHWYQQKSG
L42 L43 L44 L45 L46 L47 L48 L49 L50 L51
TSPKRWIYDT
L52 L53 L54 L55 L56 L57 L58 L59 L60 L61
SKLPSGVPGR
L62 L63 L64 L65 L66 L67 L68 L69 L70 L71
FSGSGSGTSY
L72 L73 L74 L75 L76 L77 L78 L79 L80 L81
SLTISSMEAE
L82 L83 L84 L85 L86 L87 L88 L89 L90 L91
DAATYYCQQW
L92 L93 L94 L95 L96 L97 L98 L99 L100 L101
SSNPPTFGAG
L102 L103 L104 L105 L106 L107 L108 L109
TKLEVKRA
Antigen typeOn chain idStructure
Hapten A

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
A/BGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 SASSSVSSVH
CDRL2 DTSKLPS
CDRL3 QQWSSNPPT
CDRH1 GYSITSGY
CDRH2 HYRGT
CDRH3 DDFYSDY
VH-VL orientation:
(see plot)
AngleValue
HL -67.0°
HC1 75.8°
HC2 124.5°
LC1 116.8°
LC2 85.1°
dc 16.1 Å

Downloads and links.

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Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
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