Structure summary for 3GGW

Detailed entry information.

Key:

Heavy Chains
Light Chains
Bound Antigen Chains
Chothia CDRs
Other

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Crystal Structure Of Fab F22-4 In Complex With A Carbohydrate-Mimetic Peptide

ItemInfo
PDB code: 3ggw
Organism: MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
In complex: True
Fvs present: 2
Binding affinity (KD): 2.9e-06 M
ΔG: -7.55 kcal/mol
Affinity method: ITC
Temperature: 25 °C
Source: Paper Link
Light chain type: Kappa
PDB has constant region: True

This PDB has 2 antibody variable fragment(s)

Fab Details:
ItemInfo
Heavy Chain B
Light Chain A
Heavy V / J / C subgroups IGHV6 / IGHJ4 / IGHG1
Light V / J / C subgroups IGKV2 / IGKJ1 / IGKC
Bound-state Bound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
Chain E
Type peptide
Name peptide b1
Species SYNTHETIC CONSTRUCT

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH B Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVKVEESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSMKI
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCVVSGLTFS
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
NYWMSWVRQS
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PEKGLEWVAE
H51 H52 H52AH52BH52CH53 H54 H55 H56 H57
IRLKSDNYAT
H58 H59 H60 H61 H62 H63 H64 H65 H66 H67
YYAESVKGKF
H68 H69 H70 H71 H72 H73 H74 H75 H76 H77
TISRDDSKSR
H78 H79 H80 H81 H82 H82AH82BH82CH83 H84
LYLQMNNLRT
H85 H86 H87 H88 H89 H90 H91 H92 H93 H94
EDTGIYYCFL
H95 H96 H101 H102 H103 H104 H105 H106 H107 H108
PMDYWGQGTS
H109 H110 H111 H112 H113
VTVSS
VL A Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
DIVMTQAAFS
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
NPVTLGTSAS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ISCRSSKSLL
L30AL30BL30CL30DL30EL31 L32 L33 L34 L35
HSDGITYLYW
L36 L37 L38 L39 L40 L41 L42 L43 L44 L45
YLQKPGQSPH
L46 L47 L48 L49 L50 L51 L52 L53 L54 L55
LLIYHLSNLA
L56 L57 L58 L59 L60 L61 L62 L63 L64 L65
SGVPDRFSSS
L66 L67 L68 L69 L70 L71 L72 L73 L74 L75
GSGTDFTLRI
L76 L77 L78 L79 L80 L81 L82 L83 L84 L85
SRVEAEDVGI
L86 L87 L88 L89 L90 L91 L92 L93 L94 L95
YYCAHNVELP
L96 L97 L98 L99 L100 L101 L102 L103 L104 L105
RTFGGGTKLE
L106 L107 L108 L109
IKRA
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
peptide E Download
Y L E D W I K Y N N Q K

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
B/AGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSKSLLHSDGITYLY
CDRL2 HLSNLAS
CDRL3 AHNVELPRT
CDRH1 GLTFSNY
CDRH2 RLKSDNYA
CDRH3 PMDY
VH-VL orientation:
(see plot)
AngleValue
HL -60.4°
HC1 71.5°
HC2 113.2°
LC1 118.8°
LC2 81.9°
dc 16.5 Å
Fab Details:
ItemInfo
Heavy Chain D
Light Chain C
Heavy V / J / C subgroups IGHV6 / IGHJ4 / IGHG1
Light V / J / C subgroups IGKV2 / IGKJ1 / IGKC
Bound-state Bound
Species MUS MUSCULUS
ScFv? False
Constant domains present? True
Antigen Details:
ItemInfo
Chain F
Type peptide
Name peptide b1
Species SYNTHETIC CONSTRUCT

Sequence:
Chain typeChain idFasta sequenceChothia annotated sequence ( framework / CDRs )
VH D Download
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10
EVKVEESGGG
H11 H12 H13 H14 H15 H16 H17 H18 H19 H20
LVQPGGSMKI
H21 H22 H23 H24 H25 H26 H27 H28 H29 H30
SCVVSGLTFS
H31 H32 H33 H34 H35 H36 H37 H38 H39 H40
NYWMSWVRQS
H41 H42 H43 H44 H45 H46 H47 H48 H49 H50
PEKGLEWVAE
H51 H52 H52AH52BH52CH53 H54 H55 H56 H57
IRLKSDNYAT
H58 H59 H60 H61 H62 H63 H64 H65 H66 H67
YYAESVKGKF
H68 H69 H70 H71 H72 H73 H74 H75 H76 H77
TISRDDSKSR
H78 H79 H80 H81 H82 H82AH82BH82CH83 H84
LYLQMNNLRT
H85 H86 H87 H88 H89 H90 H91 H92 H93 H94
EDTGIYYCFL
H95 H96 H101 H102 H103 H104 H105 H106 H107 H108
PMDYWGQGTS
H109 H110 H111 H112 H113
VTVSS
VL C Download
L1 L2 L3 L4 L5 L6 L7 L8 L9 L10
DIVMTQAAFS
L11 L12 L13 L14 L15 L16 L17 L18 L19 L20
NPVTLGTSAS
L21 L22 L23 L24 L25 L26 L27 L28 L29 L30
ISCRSSKSLL
L30AL30BL30CL30DL30EL31 L32 L33 L34 L35
HSDGITYLYW
L36 L37 L38 L39 L40 L41 L42 L43 L44 L45
YLQKPGQSPH
L46 L47 L48 L49 L50 L51 L52 L53 L54 L55
LLIYHLSNLA
L56 L57 L58 L59 L60 L61 L62 L63 L64 L65
SGVPDRFSSS
L66 L67 L68 L69 L70 L71 L72 L73 L74 L75
GSGTDFTLRI
L76 L77 L78 L79 L80 L81 L82 L83 L84 L85
SRVEAEDVGI
L86 L87 L88 L89 L90 L91 L92 L93 L94 L95
YYCAHNVELP
L96 L97 L98 L99 L100 L101 L102 L103 L104 L105
RTFGGGTKLE
L106 L107 L108 L109
IKRA
Antigen typeChain idFasta sequenceSequence (Clustal colouring)
peptide F Download
Y L E D W I K Y N N Q K

Antibody i-Patch annotation:
Fab heavy/lightchainLink to the Antibody i-Patch annotation (What is this?)
D/CGet AB i-Patch annotation
Chothia CDR information:
CDRSequence
CDRL1 RSSKSLLHSDGITYLY
CDRL2 HLSNLAS
CDRL3 AHNVELPRT
CDRH1 GLTFSNY
CDRH2 RLKSDNYA
CDRH3 PMDY
VH-VL orientation:
(see plot)
AngleValue
HL -62.2°
HC1 71.6°
HC2 111.9°
LC1 118.4°
LC2 80.2°
dc 16.4 Å

Downloads and links.

ItemDownload link
Full structureDownload
Chothia structureDownload
Summary fileDownload
Entry in the PDBSee the file on the PDB
Entry in IMGTSee the IMGT entry
Flag misannotation