Antibody Tools

Download antibody software developed by OPIG

We have developed a decoy re-scoring method which uses antibody-specific statistics to identify better decoys. Using our re-scoring scheme you can re-order the decoys obtained from ZDOCK to enrich the top ten results with more native antibody-antigen poses generated by the docking software. The re-scoring correctly identifies more native antibody-antigen decoys even if a homology model is supplied as the antibody structure.

For a full description of the method or if you use this software, please refer to:

Krawczyk et al. Antibody i-Patch prediction of the antibody binding site improves rigid local antibody–antigen docking. PEDS (2013)

We have developed a CDR contact prediction method, Antibody i-Patch, which uses antibody-specific statistics. The software annotates CDR residues with a score indicating the likelihood of the given residue to be in contact with the supplied antigen. Antibody i-Patch works well with only the homology model of the antibody supplied as input.

For a full description of the method or if you use this software, please refer to:

Krawczyk et al. Antibody i-Patch prediction of the antibody binding site improves rigid local antibody–antigen docking. PEDS (2013)

We have developed a method and tool, ABangle, to calculate and analyse the orientation between the antibody variable domains, VH and VL.

For a full description of the method or if you use this software, please refer to:

Dunbar et al. ABangle: characterising the VH–VL orientation in antibodies. PEDS (2013)