| Therapeutic | Tocilizumab |
| Target | IL6R |
| Heavy Chain | QVQLQESGPGLVRPSQTLSLTCTVSGYSITSDHAWSWVRQPPGRGLEWIGYISYSGITTYNPSLKSRVTMLRDTSKNQFSLRLSSVTAADTAVYYCARSLARTTAMDYWGQGSLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCRASQDISSYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQGNTLPYTFGQGTKVEIK |
| 100% seqID Fv Structure | None |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | na |
| INN Year Proposed | 2004 |
| INN Year Recommended | 2004 |
| Companies Involved | Assistance Publique Hopitaux de Paris%3BCharite - Universitatsmedizin Berlin%3BChugai Pharmaceutical%3BHospital for Special Surgery%3BJW Pharmaceutical%3BRoche%3BUniversity Hospital Inselspital%3BUniversity Hospital%3BOsaka University Tubingen%3BUniversity of Bern%3BUniversity of Pittsburgh |
| Conditions Approved | Drug hypersensitivity%3BGiant cell arteritis%3BGiant lymph node hyperplasia%3BJuvenile rheumatoid arthritis%3BRheumatoid arthritis%3BVasculitis |
| Conditions Active | Adult-onset Still%27s disease%3BOsteoarthritis%3BSystemic scleroderma%3BAmyotrophic lateral sclerosis%3BDermatomyositis%3BFamilial Mediterranean fever%3BPolymyalgia rheumatica%3BPolymyositis%3BPulmonary arterial hypertension%3BSchnitzler syndrome%3BUrogenital cancer |
| Conditions Discontinued | Chronic lymphocytic leukaemia%3BAnkylosing spondylitis%3BCrohn%27s disease%3BMultiple myeloma%3BPancreatic cancer%3BSystemic lupus erythematosus |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
