Thera-SAbDab

MILATUZUMAB

> Structural Summary

Therapeutic	Milatuzumab
Target	CD74
Heavy Chain	QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGVNWIKQAPGQGLQWMGWINPNTGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKNEAWFAYWGQGTLVTVSS
Light Chain	DIQLTQSPLSLPVTLGQPASISCRSSQSLVHRNGNTYLHWFQQRPGQSPRLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSSHVPPTFGAGTRLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (June '19)	Phase-I/II
Estimated Status (June '19)	Active
Recorded Developmental Technology	na
INN Year Proposed	2007
INN Year Recommended	2008
Companies Involved	Immunomedics
Conditions Approved	na
Conditions Active	Systemic lupus erythematosus
Conditions Discontinued	Graft-versus-host disease, Haematological malignancies, Chronic lymphocytic leukaemia, Multiple myeloma, Non-Hodgkin's lymphoma
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]