Thera-SAbDab

FRESOLIMUMAB

>   Structural Summary
TherapeuticFresolimumab
TargetTGFB
Heavy ChainQVQLVQSGAEVKKPGSSVKVSCKASGYTFSSNVISWVRQAPGQGLEWMGGVIPIVDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLVLDAMDYWGQGTLVTVSS
Light ChainETVLTQSPGTLSLSPGERATLSCRASQSLGSSYLAWYQQKPGQAPRLLIYGASSRAPGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYADSPITFGQGTRLEIK
100% seqID Fv StructureNone
99% seqID Fv Structure3eo0 [Fvs: BA, DC], 3eo1 [Fvs: BA, ED, HG, KJ], 4kv5 [Fvs: EF, GK, HL, JI], 4kxz [Fvs: HL, JI, NM, QP]
95-98% seqID Fv StructureNone
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Fresolimumab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 99.56%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
fresolimumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S
4kxz Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
fresolimumab E T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
4kxz - T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
Sequence identity: 99.56%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
fresolimumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S
4kv5 Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
fresolimumab E T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
4kv5 - T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
Sequence identity: 99.56%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
fresolimumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S
3eo0 Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
fresolimumab E T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
3eo0 - T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
Sequence identity: 99.56%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
fresolimumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S
3eo1 Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y T F S S N V I S W V R Q A P G Q G L E W M G G V I P I V D I A N Y A Q R F K G R V T I T A D E S T S T T Y M E L S S L R S E D T A V Y Y C A S T L G L V L D A M D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
fresolimumab E T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
3eo1 - T V L T Q S P G T L S L S P G E R A T L S C R A S Q S L G S S Y L A W Y Q Q K P G Q A P R L L I Y G A S S R A P G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y A D S P I T F G Q G T R L E I K
>   Metadata
FormatWhole mAb
IsotypeG4
Highest Clinical Trial (June '19)Phase-I
Estimated Status (June '19)Active
Recorded Developmental TechnologyCAT Phage Display
INN Year Proposed2009
INN Year Recommended2010
Companies InvolvedCambridge Antibody Technology, Baylor College of Medicine, Genzyme Corporation, Sanofi Genzyme
Conditions Approvedna
Conditions ActiveOsteogenesis imperfecta
Conditions DiscontinuedFibrosis, Malignant melanoma, Pulmonary fibrosis, Renal cancer, Focal segmental glomerulosclerosis
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]