| Therapeutic | Nivolumab |
| Target | PDCD1 |
| Heavy Chain | QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS |
| Light Chain | EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK |
| 100% seqID Fv Structure | 5ggq%3AHL%2F5wt9%3AHL%2F5ggr%3AHL%3AAB [Fvs: ] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 5ggq%3AHL%2F5wt9%3AHL%2F5ggr%3AHL%3AAB [Fvs: ] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | Medarex UltiMAb Mouse |
| INN Year Proposed | 2012 |
| INN Year Recommended | 2013 |
| Companies Involved | Aduro BioTech%3BAIO Studien gGmbH%3BAustralian and New Zealand Urogenital and Prostate Cancer Group%3BBarbara Ann Karmanos Cancer Institute%3BBavarian Nordic%3BBig Ten Cancer Research Consortium%3BBristol-Myers Squibb%3BCanadian Cancer Trials Group%3BCelleron Therapeutics%3BClatterbridge Cancer Centre NHS Foundation Trust%3BClovis Oncology%3BCurie Institute%3BDaiichi Sankyo Company%3BDana-Farber Cancer Institute%3BDuke University Medical Center%3BEisai Inc%3BEli Lilly%3BEmory University%3BEuropean Thoracic Oncology Platform%3BExelixis%3BFrontier Science foundation%3BGrupo Espanol Multidisciplinar de Melanoma%3BH. Lee Moffitt Cancer Center and Research Institute%3BHellenic Genitourinary Cancer Group%3BHoosier Cancer Research Network%3BHOVON Foundation%3BIncyte Corporation%3BIntergroupe Francophone de Cancerologie Thoracique%3BJanssen Biotech%3BJanssen Research %26 Development%3BKansai Medical University%3BKyoto Breast Cancer Research Network%3BM. D. Anderson Cancer Center%3BMassachusetts General Hospital%3BMedarex%3BNantes University Hospital%3BNational Cancer Center %28Tokyo%29%3BNational Cancer Centre %28Singapore%29%3BNational Cancer Institute %28USA%29%3BNektar Therapeutics%3BNeon Therapeutics%3BNetherlands Cancer Institute%3BNorthwestern University%3BOno Pharmaceutical%3BPharmacyclics%3BPrECOG%3BSeattle Genetics%3BSidney Kimmel Cancer Center%3BSidney Kimmel Comprehensive Cancer Center at Johns Hopkins%3BSyneos Health%3BThe University of Montreal Hospital Research Center%3BUNICANCER%3BUniversity College London%3BUniversity of Liverpool%3BUniversity of Pittsburgh%3BUniversity of Texas M. D. Anderson Cancer Center%3BVanderbilt-Ingram Cancer Center%3BZucero Therapeutics |
| Conditions Approved | Colorectal cancer%3BGastric cancer%3BHead and neck cancer%3BHodgkin%27s disease%3BMalignant melanoma%3BNon-small cell lung cancer%3BRenal cell carcinoma%3BUrogenital cancer%3BLiver cancer%3BMesothelioma%3BSmall cell lung cancer |
| Conditions Active | Bladder cancer%3BFallopian tube cancer%3BGlioblastoma%3BMultiple myeloma%3BOesophageal cancer%3BOvarian cancer%3BPeritoneal cancer%3BNon-Hodgkin%27s lymphoma%3BAcute myeloid leukaemia%3BAdrenocortical carcinoma%3BBiliary cancer%3BBrain metastases%3BBreast cancer%3BBronchopulmonary dysplasia%3BCancer%3BCervical cancer%3BCholangiocarcinoma%3BChronic lymphocytic leukaemia%3BCNS cancer%3BDiffuse large B cell lymphoma%3BFollicular lymphoma%3BGenitourinary disorders%3BLeucoplakia%3BLiver metastases%3BMeningeal carcinomatosis%3BMyelodysplastic syndromes%3BNasopharyngeal cancer%3BOropharyngeal cancer%3BPancreatic cancer%3BPenile cancer%3BProstate cancer%3BSoft tissue sarcoma%3BSolid tumours%3BTesticular cancer%3BThyroid cancer%3BUterine cancer%3BUveal melanoma%3BHaematological malignancies%3BLymphoma%3BRectal cancer%3BChronic myeloid leukaemia%3BGlioma%3BHepatitis C%3BSepsis |
| Conditions Discontinued | na |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
