Thera-SAbDab

POLATUZUMAB

> Structural Summary

Therapeutic	Polatuzumab
Target	CD79B
Heavy Chain	EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSS
Light Chain	DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb ADC
Isotype	G1
Highest Clinical Trial (August '23)	Approved
Estimated Status (August '23)	Active
Recorded Developmental Technology	na
INN Year Proposed	2012
INN Year Recommended	2013
Companies Involved	Chugai Pharmaceutical%3BGenentech%3BRoche
Conditions Approved	Diffuse large B cell lymphoma
Conditions Active	Non-Hodgkin%27s lymphoma%3BFollicular lymphoma
Conditions Discontinued	Chronic lymphocytic leukaemia
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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