Therapeutic | Dinutuximab |
Target | Ganglioside GD2 |
Heavy Chain | EVQLLQSGPELEKPGASVMISCKASGSSFTGYNMNWVRQNIGKSLEWIGAIDPYYGGTSYNQKFKGRATLTVDKSSSTAYMHLKSLTSEDSAVYYCVSGMEYWGQGTSVTVSS |
Light Chain | EIVMTQSPATLSVSPGERATLSCRSSQSLVHRNGNTYLHWYLQKPGQSPKLLIHKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPLTFGAGTKLELK |
100% seqID Fv Structure | None |
99% seqID Fv Structure | None |
95-98% seqID Fv Structure | 4trp [Fvs: HL], 4tuj [Fvs: AB, CD], 4tuk [Fvs: HL], 4tul [Fvs: HL], 4tuo [Fvs: AB, CD] |
95-98% seqID Structure | 4tuj [Fvs: AB, CD] |
95-98% seqID Structure | 4tul [Fvs: HL] |
95-98% seqID Structure | 4trp [Fvs: HL] |
95-98% seqID Structure | 4tuo [Fvs: AB, CD] |
95-98% seqID Structure | 4tuk [Fvs: HL] |
There are no identical PDB matches to this therapeutic Fv. Click here to build a model with ABodyBuilder. |
Non-identical sequences have been numbered using the Chothia scheme and aligned to Dinutuximab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.
Heavy chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
4tuj | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
Light chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 30D | 30E | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | I | V | M | T | Q | S | P | A | T | L | S | V | S | P | G | E | R | A | T | L | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
4tuj | D | V | V | M | T | Q | T | P | L | S | L | P | V | S | L | G | D | Q | A | S | I | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
Heavy chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
4tul | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
Light chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 30D | 30E | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | I | V | M | T | Q | S | P | A | T | L | S | V | S | P | G | E | R | A | T | L | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
4tul | D | V | V | M | T | Q | T | P | L | S | L | P | V | S | L | G | D | Q | A | S | I | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
Heavy chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
4trp | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
Light chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 30D | 30E | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | I | V | M | T | Q | S | P | A | T | L | S | V | S | P | G | E | R | A | T | L | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
4trp | D | V | V | M | T | Q | T | P | L | S | L | P | V | S | L | G | D | Q | A | S | I | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
Heavy chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
4tuo | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
Light chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 30D | 30E | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | I | V | M | T | Q | S | P | A | T | L | S | V | S | P | G | E | R | A | T | L | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
4tuo | D | V | V | M | T | Q | T | P | L | S | L | P | V | S | L | G | D | Q | A | S | I | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
Heavy chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
4tuk | E | V | Q | L | L | Q | S | G | P | E | L | E | K | P | G | A | S | V | M | I | S | C | K | A | S | G | S | S | F | T | G | Y | N | M | N | W | V | R | Q | N | I | G | K | S | L | E | W | I | G | A | I | D | P | Y | Y | G | G | T | S | Y | N | Q | K | F | K | G | R | A | T | L | T | V | D | K | S | S | S | T | A | Y | M | H | L | K | S | L | T | S | E | D | S | A | V | Y | Y | C | V | S | G | M | E | Y | W | G | Q | G | T | S | V | T | V | S | S |
Light chain
Position | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 30D | 30E | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 95A | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dinutuximab | E | I | V | M | T | Q | S | P | A | T | L | S | V | S | P | G | E | R | A | T | L | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
4tuk | D | V | V | M | T | Q | T | P | L | S | L | P | V | S | L | G | D | Q | A | S | I | S | C | R | S | S | Q | S | L | V | H | R | N | G | N | T | Y | L | H | W | Y | L | Q | K | P | G | Q | S | P | K | L | L | I | H | K | V | S | N | R | F | S | G | V | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | K | I | S | R | V | E | A | E | D | L | G | V | Y | F | C | S | Q | S | T | H | V | P | P | L | T | F | G | A | G | T | K | L | E | L | K |
Follow these links to our prediction tools:
Format | Whole mAb |
Isotype | G1 |
Highest Clinical Trial (August '23) | Approved |
Estimated Status (August '23) | Active |
Recorded Developmental Technology | na |
INN Year Proposed | 2013 |
INN Year Recommended | 2014 |
Companies Involved | National Cancer Institute (USA), New Approaches to Neuroblastoma Therapy Consortium, St. John of God Foundation, United Therapeutics Corporation |
Conditions Approved | Neuroblastoma |
Conditions Active | Small cell lung cancer |
Conditions Discontinued | Malignant melanoma |
Notes | na |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]