Thera-SAbDab

ANETUMAB

> Structural Summary

Therapeutic	Anetumab
Target	MSLN
Heavy Chain	QVELVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQAPGKGLEWMGIIDPGDSRTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGQLYGGTYMDGWGQGTLVTVSS
Light Chain	DIALTQPASVSGSPGQSITISCTGTSSDIGGYNSVSWYQQHPGKAPKLMIYGVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYDIESATPVFGGGTKLTVL
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

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Format	Whole mAb ADC
Isotype	G1
Highest Clinical Trial (June '19)	Phase-II
Estimated Status (June '19)	Active
Recorded Developmental Technology	MorphoSys HuCAL Phage Display
INN Year Proposed	2013
INN Year Recommended	2014
Companies Involved	Bayer HealthCare, ImmunoGen, MorphoSys, National Cancer Institute (USA)
Conditions Approved	na
Conditions Active	Lung cancer, Mesothelioma, Ovarian cancer, Pancreatic cancer, Solid tumours, Non-small cell lung cancer
Conditions Discontinued	Non-small cell lung cancer
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]