| Therapeutic | Isatuximab |
| Target | CD38 |
| Heavy Chain | QVQLVQSGAEVAKPGTSVKLSCKASGYTFTDYWMQWVKQRPGQGLEWIGTIYPGDGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYGSNSLDYWGQGTSVTVSS |
| Light Chain | DIVMTQSHLSMSTSLGDPVSITCKASQDVSTVVAWYQQKPGQSPRRLIYSASYRYIGVPDRFTGSGAGTDFTFTISSVQAEDLAVYYCQQHYSPPYTFGGGTKLEIK |
| 100% seqID Fv Structure | 4cmh%3ABC [Fvs: ] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 4cmh%3ABC [Fvs: ] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (August '23) | Preregistration |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | na |
| INN Year Proposed | 2014 |
| INN Year Recommended | 2015 |
| Companies Involved | ImmunoGen%3BHuntsman Cancer Institute%3BRoche%3BSanofi |
| Conditions Approved | na |
| Conditions Active | Multiple myeloma%3BAcute myeloid leukaemia%3BPrecursor cell lymphoblastic leukaemia-lymphoma%3BT-cell lymphoma%3BColorectal cancer%3BDiffuse large B cell lymphoma%3BHodgkin%27s disease%3BNon-small cell lung cancer%3BPeripheral T-cell lymphoma%3BProstate cancer%3BSolid tumours%3BUrogenital cancer |
| Conditions Discontinued | na |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
