| Therapeutic | Toripalimab |
| Target | PDCD1 |
| Heavy Chain | QGQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPIHGLEWIGVIESETGGTAYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCAREGITTVATTYYWYFDVWGQGTTVTVSS |
| Light Chain | DVVMTQSPLSLPVTLGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPLTFGQGTKLEIK |
| 100% seqID Fv Structure | 6jbt%3AHL [Fvs: ] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 6jbt%3AHL [Fvs: ] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | na |
| INN Year Proposed | 2018 |
| INN Year Recommended | 2019 |
| Companies Involved | Fudan University%3BPeking University%3BShanghai Junshi Biosciences%3BSun Yat-Sen University |
| Conditions Approved | Malignant melanoma |
| Conditions Active | Nasopharyngeal cancer%3BOesophageal cancer%3BBiliary cancer%3BGastric cancer%3BNon-small cell lung cancer%3BSolid tumours%3BUrogenital cancer%3BHead and neck cancer%3BAlveolar soft part sarcoma%3BBreast cancer%3BCancer%3BLiver cancer%3BLymphoma%3BNeuroendocrine tumours%3BRenal cancer |
| Conditions Discontinued | na |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
