Thera-SAbDab

TARCOLIMAB

>   Structural Summary
TherapeuticTarcolimab
TargetVEGFA
Heavy ChainEVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSS
Light ChainDIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIK
100% seqID Fv Structure1cz8 [Fvs: HL, YX]
99% seqID Fv StructureNone
95-98% seqID Fv Structure1bj1 [Fvs: HL, KJ], 6bft [Fvs: AB, HL]
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Tarcolimab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 97.83%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
tarcolimab E V Q L V E S G G G L V Q P G G S L R L S C A A S G Y D F T H Y G M N W V R Q A P G K G L E W V G W I N T Y T G E P T Y A A D F K R R F T F S L D T S K S T A Y L Q M N S L R A E D T A V Y Y C A K Y P Y Y Y G T S H W Y F D V W G Q G T L V T V S S
1bj1 E V Q L V E S G G G L V Q P G G S L R L S C A A S G Y T F T N Y G M N W V R Q A P G K G L E W V G W I N T Y T G E P T Y A A D F K R R F T F S L D T S K S T A Y L Q M N S L R A E D T A V Y Y C A K Y P H Y Y G S S H W Y F D V W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
tarcolimab D I Q L T Q S P S S L S A S V G D R V T I T C S A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y F T S S L H S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y S T V P W T F G Q G T K V E I K
1bj1 D I Q M T Q S P S S L S A S V G D R V T I T C S A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y F T S S L H S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y S T V P W T F G Q G T K V E I K
Sequence identity: 96.96%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
tarcolimab E V Q L V E S G G G L V Q P G G S L R L S C A A S G Y D F T H Y G M N W V R Q A P G K G L E W V G W I N T Y T G E P T Y A A D F K R R F T F S L D T S K S T A Y L Q M N S L R A E D T A V Y Y C A K Y P Y Y Y G T S H W Y F D V W G Q G T L V T V S S
6bft E V Q L V E S G G G L V Q P G G S L R L S C A A S G Y D F D N Y G M N W V R Q A P G K G L E W V G W I N T Y T G E P T Y A A D F K R R F T F S L D T S K S T A Y L Q M N S L R A E D T A V Y Y C A K Y P H Y Y G S S H W Y F D V W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
tarcolimab D I Q L T Q S P S S L S A S V G D R V T I T C S A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y F T S S L H S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y S T V P W T F G Q G T K V E I K
6bft D I Q M T Q S P S S L S A S V G D R V T I T C S A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y F T D D L H S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y S T V P W T F G Q G T K V E I K
>   Metadata
FormatWhole mAb
IsotypeG1
Highest Clinical Trial (August '23)TBC
Estimated Status (August '23)Active
Recorded Developmental TechnologyTBC
INN Year Proposed2021
INN Year RecommendedNone
Companies InvolvedTBC
Conditions ApprovedTBC
Conditions ActiveTBC
Conditions DiscontinuedTBC
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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