Thera-SAbDab

INCLACUMAB

> Structural Summary

Therapeutic	Inclacumab
Target	SELP
Heavy Chain	EVQLVESGGGLVRPGGSLRLSCAASGFTFSNYDMHWVRQATGKGLEWVSAITAAGDIYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGRYSGSGSYYNDWFDPWGQGTLVTVSS
Light Chain	EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G4
Highest Clinical Trial (August '23)	Phase-II
Estimated Status (August '23)	Discontinued
Recorded Developmental Technology	Medarex UltiMAb Mouse
INN Year Proposed	2011
INN Year Recommended	2012
Companies Involved	Genmab, Roche, Global Blood Therapeutics
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Acute coronary syndromes, Myocardial infarction, Peripheral vascular disorders
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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