Thera-SAbDab

OTLERTUZUMAB

> Structural Summary

Therapeutic	Otlertuzumab
Target	CD37
Heavy Chain	EVQLVQSGAEVKKPGESLKISCKGSGYSFTGYNMNWVRQMPGKGLEWMGNIDPYYGGTTYNRKFKGQVTISADKSISTAYLQWSSLKASDTAMYYCARSVGPFDSWGQGTLVTVSS
Light Chain	EIVLTQSPATLSLSPGERATLSCRASENVYSYLAWYQQKPGQAPRLLIYFAKTLAEGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHHSDNPWTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	di-scFv%2BFc
Isotype	G1
Highest Clinical Trial (August '23)	Phase-II
Estimated Status (August '23)	Discontinued
Recorded Developmental Technology	ADAPTIR Monospecific Platform
INN Year Proposed	2013
INN Year Recommended	2014
Companies Involved	Trubion Pharmaceuticals%3BAptevo Therapeutics
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Chronic lymphocytic leukaemia%3BNon-Hodgkin%27s lymphoma%3BPeripheral T-cell lymphoma
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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