ABangle

VH-VL orientation analysis.

The relative orientation between the antibody variable domains (VH and VL) influences the topology of the antigen binding site. It is also important to consider when building high-resolution models of antibodies.
The VH-VL orientation can be characterised using six measures:

HLthe torsion angle between H1 and L1
HC1the bend angle between H1 and C
HC2the bend angle between H2 and C
LC1the bend angle between L1 and C
LC2the bend angle between L2 and C
dcthe length of C
Use the plots below to select structures based on their VH-VL orientation.
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Use the options below to select a set of structures.
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Add another position


Select a single PDB code to see where it lays in VH-VL orientation space.
To select a specific Fv, use its chain identifiers e.g. 12e8_PM.
Add codes to compare structures
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Add more pdbs

Select a single Fv identifier to find structures with similar VH-VL orientations.
To select a specific Fv, use its chain identifiers e.g. 12e8_PM.
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To run ABangle locally and use more features, download the executable here.
If you use this software please cite this paper.