TAP: Therapeutic Antibody Profiler

How similar is your antibody to clinical-stage therapeutics?

Please cite our paper "Five Computational Developability Guidelines for Therapeutic Antibody Profiling" if making use of these datasets.

  • The 242 Clinical-Stage Therapeutics (CST) models that set the TAP Guidelines in the PNAS paper can be found here.

  • The 242CST sequences can be found in the paper SI here (Dataset S2).

  • The TAP Guidelines were last updated on 23rd February 2019. We are now tracking 302 post Phase-I therapeutics. The 302 models that set the most recent TAP Guidelines can be found here. Their TAP metric values can be found here.The guidelines set by these models are below:



    • PropertyAmber Region (23rd February 2019)Red Region (23rd February 2019)
      Total CDR Length (L) 39 ≤ L ≤ 43 L < 39
      54 ≤ L ≤ 60 L > 60
      Patches of Surface Hydrophobicity (PSH) 90.074 ≤ PSH ≤ 100.226 PSH < 90.074
      155.806 ≤ PSH ≤ 199.165* PSH > 199.165*
      Patches of Positive Charge (PPC) 1.255 ≤ PPC ≤ 3.162 PPC > 3.162
      Patches of Negative Charge (PNC) 1.846 ≤ PNC ≤ 3.463 PNC > 3.463
      Structural Fv Charge Symmetry Parameter (SFvCSP) -20.40 ≤ SFvCSP ≤ -6.194 SFvCSP < -20.40
      *These higher PSH values are set by two mAbs (Iscalimab & Mavrilimab) which require ab initio modelling for L3 and L3 & H3 respectively. This is likely to artificially elevate their value through poorer model quality. We believe that this threshold should lie in the range 170-200.

      Please contact us at opig <~at~> stats.ox.ac.uk for our most recent list of CST sequences (currently 302).

The developability guidelines used by TAP are explained in 'Five Computational Developability Guidelines for Therapeutic Antibody Profiling', which is now published in PNAS (link).

To use this application, you only require an amino acid antibody variable domain heavy and light chain sequence.

The Therapeutic Antibody Profiler (TAP) compares your antibody variable domain sequence against five developability guidelines derived from clinical-stage therapeutic values.

TAP uses ABodyBuilder, with side-chains modelled by PEARS, to generate a model structure of your antibody. The standard implementation takes around 30 seconds.

If the H3 loop can not be modelled using FREAD, it defaults to modelling the loop with MODELLER (+~3mins). SPHINX can also be used for more accurate modelling, but expect a large increase in runtime.

TAP then calculates the following properties (explained in the paper) to see if your antibody design is commenserate with those of clinical-stage therapeutics:

  1. Total CDR Length
  2. Patches of Surface Hydrophobicity (PSH) metric across the CDR Vicinity
  3. Patches of Positive Charge (PPC) metric across the CDR Vicinity
  4. Patches of Negative Charge (PNC) metric across the CDR Vicinity
  5. Structural Fv Charge Symmetry Parameter (SFvCSP)

TAP also outputs...

  • An interactive representation of your antibody model, allowing you to visualise hydrophobic/charge patches on the Van der Waals surface. The model is downloadable.
  • A representation showing predicted model accuracy, communicating the confidence you should have in our metric values
  • Sequence Liabilites likely to lead to post- or co-translational modification
  • North-defined length-independent Canonical Forms (excluding the H3 loop)

For a sample TAP output, please click here.

If you are not sure how to use TAP, please look at the submission guidelines here.


TAP: Single Antibody Submission [Help]


Options

If FREAD cannot model your CDRH3 loop, should ABodyBuilder use Modeller or Sphinx (a hybrid ab initio/knowledge-based method - more accurate, but expect a longer runtime)?


Currently running 4 job(s). Max permitted is 20

Job IDJob typeSubmission timeStatus
SEJ (?)TAPFriday 19th of April 2019 07:27:54 PMRunning
SEJ (?)TAPFriday 19th of April 2019 06:43:52 PMRunning
SEJ (?)TAPFriday 19th of April 2019 03:38:53 AMDone
SEJ (?)TAPFriday 19th of April 2019 03:33:50 AMDone
SEJ (?)TAPThursday 18th of April 2019 11:00:06 AMDone
SEJ (?)TAPThursday 18th of April 2019 10:59:45 AMDone
SEJ (?)TAPThursday 18th of April 2019 10:07:34 AMDone
SEJ (?)TAPThursday 18th of April 2019 09:15:21 AMDone
SEJ (?)TAPThursday 18th of April 2019 05:38:45 AMDone
SEJ (?)TAPThursday 18th of April 2019 05:27:42 AMDone
SEJ (?)TAPThursday 18th of April 2019 03:43:08 AMDone
SEJ (?)TAPThursday 18th of April 2019 03:27:17 AMDone
SEJ (?)TAPWednesday 17th of April 2019 09:36:26 PMDone
SEJ (?)TAPWednesday 17th of April 2019 09:34:21 PMDone
SEJ (?)TAPWednesday 17th of April 2019 09:18:01 PMDone
SEJ (?)TAPWednesday 17th of April 2019 09:12:19 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:42:33 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:40:11 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:35:31 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:33:25 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:30:58 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:28:12 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:26:18 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:19:48 PMDone
SEJ (?)TAPWednesday 17th of April 2019 06:04:20 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:46:49 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:42:09 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:27:06 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:20:41 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:04:11 PMDone
SEJ (?)TAPWednesday 17th of April 2019 04:56:08 PMDone
SEJ (?)TAPWednesday 17th of April 2019 04:48:00 PMDone
SEJ (?)TAPWednesday 17th of April 2019 04:32:37 PMDone
SEJ (?)TAPWednesday 17th of April 2019 04:24:49 PMDone
SEJ (?)TAPWednesday 17th of April 2019 05:48:52 AMDone
SEJ (?)TAPWednesday 17th of April 2019 05:48:43 AMDone
SEJ (?)TAPWednesday 17th of April 2019 03:32:36 AMDone
SEJ (?)TAPWednesday 17th of April 2019 12:02:14 AMDone
SEJ (?)TAPTuesday 16th of April 2019 11:34:36 PMDone
SEJ (?)TAPTuesday 16th of April 2019 11:24:37 PMDone
SEJ (?)TAPTuesday 16th of April 2019 11:19:24 PMDone
SEJ (?)TAPTuesday 16th of April 2019 11:00:36 PMDone
SEJ (?)TAPTuesday 16th of April 2019 05:36:20 PMDone
SEJ (?)TAPTuesday 16th of April 2019 04:39:05 PMDone
SEJ (?)TAPTuesday 16th of April 2019 04:35:57 PMDone
SEJ (?)TAPTuesday 16th of April 2019 04:35:53 PMDone
SEJ (?)TAPTuesday 16th of April 2019 04:35:41 PMDone
SEJ (?)TAPTuesday 16th of April 2019 04:20:26 PMDone
SEJ (?)TAPTuesday 16th of April 2019 11:27:10 AMDone
SEJ (?)TAPTuesday 16th of April 2019 04:58:54 AMDone
SEJ (?)TAPTuesday 16th of April 2019 04:57:00 AMRunning
SEJ (?)TAPMonday 15th of April 2019 11:45:35 PMDone
SEJ (?)TAPMonday 15th of April 2019 11:07:51 PMDone
SEJ (?)TAPMonday 15th of April 2019 11:07:46 PMFailed
SEJ (?)TAPMonday 15th of April 2019 11:07:24 PMDone
SEJ (?)TAPMonday 15th of April 2019 11:05:47 PMDone
SEJ (?)TAPMonday 15th of April 2019 10:56:23 PMDone
SEJ (?)TAPMonday 15th of April 2019 10:47:57 PMDone
SEJ (?)TAPMonday 15th of April 2019 10:20:31 PMDone
SEJ (?)TAPMonday 15th of April 2019 10:13:03 PMRunning
SEJ (?)TAPMonday 15th of April 2019 09:45:14 PMDone
SEJ (?)TAPMonday 15th of April 2019 09:14:15 PMDone
SEJ (?)TAPMonday 15th of April 2019 09:09:40 PMDone
SEJ (?)TAPMonday 15th of April 2019 09:07:58 PMDone
SEJ (?)TAPMonday 15th of April 2019 09:02:17 PMDone
SEJ (?)TAPMonday 15th of April 2019 08:46:34 PMDone
SEJ (?)TAPMonday 15th of April 2019 08:45:48 PMDone
SEJ (?)TAPMonday 15th of April 2019 08:40:58 PMDone
SEJ (?)TAPMonday 15th of April 2019 08:02:21 PMDone
SEJ (?)TAPMonday 15th of April 2019 08:02:08 PMDone
SEJ (?)TAPMonday 15th of April 2019 07:41:45 PMDone
SEJ (?)TAPMonday 15th of April 2019 07:05:37 PMDone
SEJ (?)TAPMonday 15th of April 2019 06:58:41 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:55:34 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:51:22 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:39:32 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:33:20 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:23:51 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:22:23 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:04:16 PMDone
SEJ (?)TAPMonday 15th of April 2019 05:00:38 PMDone
SEJ (?)TAPMonday 15th of April 2019 04:55:01 PMDone
SEJ (?)TAPMonday 15th of April 2019 04:22:01 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:53:28 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:34:47 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:28:48 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:20:32 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:20:19 PMDone
SEJ (?)TAPMonday 15th of April 2019 03:15:54 PMDone
SEJ (?)TAPMonday 15th of April 2019 02:59:15 PMDone
SEJ (?)TAPMonday 15th of April 2019 02:43:12 PMDone
SEJ (?)TAPMonday 15th of April 2019 11:51:39 AMDone
SEJ (?)TAPMonday 15th of April 2019 10:37:35 AMDone
SEJ (?)TAPMonday 15th of April 2019 10:19:22 AMDone
SEJ (?)TAPMonday 15th of April 2019 06:53:02 AMDone
SEJ (?)TAPSaturday 13th of April 2019 12:45:05 AMDone
SEJ (?)TAPFriday 12th of April 2019 09:04:59 PMDone
SEJ (?)TAPFriday 12th of April 2019 08:52:47 PMDone
SEJ (?)TAPFriday 12th of April 2019 03:15:43 PMDone
SEJ (?)TAPFriday 12th of April 2019 03:08:08 PMDone
SEJ (?)TAPFriday 12th of April 2019 03:04:40 PMDone
SEJ (?)TAPThursday 11th of April 2019 08:09:33 PMDone
SEJ (?)TAPThursday 11th of April 2019 05:27:04 PMDone
SEJ (?)TAPThursday 11th of April 2019 03:44:29 PMDone
SEJ (?)TAPThursday 11th of April 2019 02:08:15 PMDone
SEJ (?)TAPWednesday 10th of April 2019 04:51:58 PMDone
SEJ (?)TAPWednesday 10th of April 2019 04:31:18 PMDone
SEJ (?)TAPWednesday 10th of April 2019 11:52:47 AMDone
SEJ (?)TAPWednesday 10th of April 2019 10:26:18 AMDone
SEJ (?)TAPWednesday 10th of April 2019 10:23:52 AMDone
SEJ (?)TAPWednesday 10th of April 2019 02:36:40 AMDone
SEJ (?)TAPWednesday 10th of April 2019 02:29:21 AMDone
SEJ (?)TAPTuesday 9th of April 2019 07:54:43 PMDone
SEJ (?)TAPTuesday 9th of April 2019 07:19:14 PMDone
SEJ (?)TAPTuesday 9th of April 2019 07:17:48 PMFailed
SEJ (?)TAPTuesday 9th of April 2019 05:51:02 PMDone
SEJ (?)TAPTuesday 9th of April 2019 05:42:39 PMDone
SEJ (?)TAPTuesday 9th of April 2019 08:33:59 AMDone
SEJ (?)TAPMonday 8th of April 2019 06:06:30 PMDone
SEJ (?)TAPMonday 8th of April 2019 06:00:19 PMDone
SEJ (?)TAPMonday 8th of April 2019 05:19:07 PMDone
SEJ (?)TAPMonday 8th of April 2019 09:37:08 AMDone
SEJ (?)TAPMonday 8th of April 2019 09:30:58 AMFailed
SEJ (?)TAPSaturday 6th of April 2019 08:02:47 PMDone
SEJ (?)TAPSaturday 6th of April 2019 07:59:15 PMDone
SEJ (?)TAPFriday 5th of April 2019 05:50:56 PMDone
SEJ (?)TAPFriday 5th of April 2019 06:19:16 AMDone
SEJ (?)TAPFriday 5th of April 2019 02:16:00 AMDone
SEJ (?)TAPFriday 5th of April 2019 02:10:22 AMDone
SEJ (?)TAPThursday 4th of April 2019 07:20:33 PMDone
SEJ (?)TAPThursday 4th of April 2019 04:31:51 PMDone
SEJ (?)TAPThursday 4th of April 2019 03:53:31 PMDone
SEJ (?)TAPThursday 4th of April 2019 03:44:09 PMDone
SEJ (?)TAPThursday 4th of April 2019 01:42:39 PMDone
SEJ (?)TAPThursday 4th of April 2019 12:34:14 PMDone
SEJ (?)TAPThursday 4th of April 2019 11:45:07 AMDone
SEJ (?)TAPWednesday 3rd of April 2019 04:39:08 AMDone
SEJ (?)TAPWednesday 3rd of April 2019 04:37:24 AMDone
SEJ (?)TAPTuesday 2nd of April 2019 06:13:10 PMFailed
SEJ (?)TAPTuesday 2nd of April 2019 07:07:32 AMDone
SEJ (?)TAPTuesday 2nd of April 2019 06:40:03 AMDone
SEJ (?)TAPTuesday 2nd of April 2019 06:38:11 AMDone
SEJ (?)TAPTuesday 2nd of April 2019 06:34:48 AMDone
SEJ (?)TAPTuesday 2nd of April 2019 06:31:17 AMDone
SEJ (?)TAPMonday 1st of April 2019 04:02:54 PMDone
SEJ (?)TAPSunday 31st of March 2019 05:00:29 PMDone
SEJ (?)TAPSunday 31st of March 2019 09:25:27 AMDone
SEJ (?)TAPSaturday 30th of March 2019 01:58:37 PMDone
SEJ (?)TAPSaturday 30th of March 2019 01:30:11 PMDone
SEJ (?)TAPSaturday 30th of March 2019 09:59:12 AMDone
SEJ (?)TAPSaturday 30th of March 2019 08:05:16 AMDone
SEJ (?)TAPSaturday 30th of March 2019 12:53:48 AMDone
SEJ (?)TAPFriday 29th of March 2019 07:04:42 PMDone
SEJ (?)TAPFriday 29th of March 2019 07:01:14 PMDone
SEJ (?)TAPFriday 29th of March 2019 09:35:49 AMDone
SEJ (?)TAPThursday 28th of March 2019 04:28:42 PMDone
SEJ (?)TAPThursday 28th of March 2019 08:39:51 AMDone
SEJ (?)TAPThursday 28th of March 2019 08:37:11 AMDone
SEJ (?)TAPThursday 28th of March 2019 08:33:18 AMDone
SEJ (?)TAPThursday 28th of March 2019 08:30:38 AMDone
SEJ (?)TAPThursday 28th of March 2019 03:20:09 AMDone
SEJ (?)TAPThursday 28th of March 2019 12:48:02 AMDone
SEJ (?)TAPWednesday 27th of March 2019 11:30:53 PMDone
SEJ (?)TAPWednesday 27th of March 2019 03:51:22 PMDone
SEJ (?)TAPWednesday 27th of March 2019 03:48:43 PMDone
SEJ (?)TAPWednesday 27th of March 2019 03:44:44 PMDone
SEJ (?)TAPWednesday 27th of March 2019 03:11:52 PMDone
SEJ (?)TAPWednesday 27th of March 2019 03:01:12 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:55:51 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:48:07 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:21:04 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:20:00 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:14:46 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:14:05 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:13:35 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:05:54 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:04:52 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:02:22 PMDone
SEJ (?)TAPWednesday 27th of March 2019 02:01:57 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:55:13 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:54:27 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:39:38 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:38:25 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:18:08 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:17:36 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:11:34 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:10:41 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:08:36 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:07:19 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:05:53 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:04:58 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:04:00 PMDone
SEJ (?)TAPWednesday 27th of March 2019 01:03:16 PMDone
SEJ (?)TAPWednesday 27th of March 2019 09:17:50 AMDone
SEJ (?)TAPWednesday 27th of March 2019 08:40:15 AMFailed
SEJ (?)TAPWednesday 27th of March 2019 08:34:03 AMFailed
SEJ (?)TAPWednesday 27th of March 2019 08:32:47 AMDone
SEJ (?)TAPWednesday 27th of March 2019 08:31:28 AMDone
SEJ (?)TAPWednesday 27th of March 2019 08:30:00 AMDone
SEJ (?)TAPWednesday 27th of March 2019 08:29:02 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:43:52 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:42:27 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:39:18 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:38:32 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:37:06 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:36:09 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:34:53 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:33:12 AMDone
SEJ (?)TAPWednesday 27th of March 2019 03:29:01 AMDone
SEJ (?)TAPWednesday 27th of March 2019 12:55:28 AMDone
SEJ (?)TAPTuesday 26th of March 2019 10:52:46 PMDone
SEJ (?)TAPTuesday 26th of March 2019 04:17:07 PMDone
SEJ (?)TAPTuesday 26th of March 2019 02:32:47 PMDone
SEJ (?)TAPTuesday 26th of March 2019 12:38:04 PMDone
SEJ (?)TAPTuesday 26th of March 2019 08:07:17 AMDone
SEJ (?)TAPTuesday 26th of March 2019 08:06:13 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 08:02:56 AMDone
SEJ (?)TAPTuesday 26th of March 2019 07:58:53 AMDone
SEJ (?)TAPTuesday 26th of March 2019 07:54:54 AMDone
SEJ (?)TAPTuesday 26th of March 2019 07:51:49 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 06:51:55 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 06:51:09 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 06:45:33 AMDone
SEJ (?)TAPTuesday 26th of March 2019 06:41:30 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 06:20:28 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 06:14:58 AMDone
SEJ (?)TAPTuesday 26th of March 2019 04:11:11 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:56:38 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:55:52 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:55:08 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:54:19 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 03:54:06 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:52:59 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:51:31 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:50:54 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:50:07 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:49:20 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:48:35 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:47:52 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:47:15 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:43:30 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 03:40:55 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 03:40:09 AMFailed
SEJ (?)TAPTuesday 26th of March 2019 03:38:54 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:37:18 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:35:25 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:33:50 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:32:23 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:31:22 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:25:15 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:18:17 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:17:11 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:15:35 AMDone
SEJ (?)TAPTuesday 26th of March 2019 03:11:32 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:48:21 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:45:12 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:43:22 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:35:45 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:34:29 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:32:29 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:28:32 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:16:48 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:08:47 AMDone
SEJ (?)TAPTuesday 26th of March 2019 02:04:43 AMDone
SEJ (?)TAPMonday 25th of March 2019 11:01:15 PMDone
SEJ (?)TAPMonday 25th of March 2019 04:00:11 PMFailed
SEJ (?)TAPMonday 25th of March 2019 03:56:25 PMDone
SEJ (?)TAPMonday 25th of March 2019 02:53:58 PMDone
SEJ (?)TAPMonday 25th of March 2019 11:46:38 AMDone
SEJ (?)TAPMonday 25th of March 2019 11:44:35 AMDone
SEJ (?)TAPMonday 25th of March 2019 10:03:06 AMDone
SEJ (?)TAPMonday 25th of March 2019 01:35:42 AMFailed
SEJ (?)TAPMonday 25th of March 2019 01:23:34 AMDone
SEJ (?)TAPSunday 24th of March 2019 11:55:31 PMDone
SEJ (?)TAPSunday 24th of March 2019 01:18:29 PMDone
SEJ (?)TAPSunday 24th of March 2019 10:58:50 AMDone
SEJ (?)TAPSaturday 23rd of March 2019 07:34:11 PMDone
SEJ (?)TAPSaturday 23rd of March 2019 07:21:14 PMDone
SEJ (?)TAPSaturday 23rd of March 2019 07:18:34 PMDone
SEJ (?)TAPSaturday 23rd of March 2019 07:14:16 PMDone
SEJ (?)TAPFriday 22nd of March 2019 01:11:15 PMDone
SEJ (?)TAPThursday 21st of March 2019 12:57:22 PMDone
SEJ (?)TAPThursday 21st of March 2019 12:47:19 PMDone
SEJ (?)TAPThursday 21st of March 2019 12:46:49 PMDone
SEJ (?)TAPThursday 21st of March 2019 08:30:19 AMDone
SEJ (?)TAPThursday 21st of March 2019 07:36:27 AMDone
SEJ (?)TAPThursday 21st of March 2019 07:25:03 AMDone
SEJ (?)TAPWednesday 20th of March 2019 06:37:07 PMDone
SEJ (?)TAPWednesday 20th of March 2019 06:33:41 PMDone
SEJ (?)TAPWednesday 20th of March 2019 06:11:09 PMDone
SEJ (?)TAPWednesday 20th of March 2019 03:46:59 PMDone
SEJ (?)TAPWednesday 20th of March 2019 09:31:51 AMDone
SEJ (?)TAPWednesday 20th of March 2019 02:44:42 AMDone
SEJ (?)TAPWednesday 20th of March 2019 02:43:09 AMDone
SEJ (?)TAPWednesday 20th of March 2019 02:33:51 AMDone
SEJ (?)TAPTuesday 19th of March 2019 10:54:54 PMDone
SEJ (?)TAPTuesday 19th of March 2019 02:45:51 PMDone
SEJ (?)TAPTuesday 19th of March 2019 02:41:29 PMDone
SEJ (?)TAPTuesday 19th of March 2019 02:38:04 PMDone
SEJ (?)TAPTuesday 19th of March 2019 02:33:38 PMDone
SEJ (?)TAPTuesday 19th of March 2019 04:12:16 AMDone
SEJ (?)TAPTuesday 19th of March 2019 01:32:13 AMDone
SEJ (?)TAPTuesday 19th of March 2019 01:28:19 AMDone
SEJ (?)TAPTuesday 19th of March 2019 01:20:50 AMDone
SEJ (?)TAPMonday 18th of March 2019 09:31:20 PMDone
SEJ (?)TAPMonday 18th of March 2019 05:18:00 PMDone
SEJ (?)TAPMonday 18th of March 2019 12:56:30 PMDone
SEJ (?)TAPSunday 17th of March 2019 05:23:01 PMDone
SEJ (?)TAPSunday 17th of March 2019 10:11:46 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:47:02 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:46:55 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:44:47 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:44:41 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:44:37 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:42:22 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:42:17 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:42:12 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:39:07 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:38:59 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:38:53 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:35:25 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:35:20 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:35:15 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:33:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:31:59 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:30:30 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:29:14 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:28:06 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:26:59 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:25:04 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:24:57 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:24:51 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:22:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:22:20 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:22:15 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:20:54 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:19:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:18:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:17:22 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:16:21 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:15:09 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:13:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:13:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:12:08 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:12:03 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:10:08 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:10:03 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:08:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:08:33 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:06:49 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:06:44 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:05:04 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:05:00 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:03:02 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:02:58 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:01:03 AMDone
SEJ (?)TAPThursday 14th of March 2019 03:00:55 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:57:08 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:57:02 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:55:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:55:22 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:54:00 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:53:56 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:51:41 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:51:31 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:49:51 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:49:47 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:48:08 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:48:03 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:32:11 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:32:07 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:30:19 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:30:15 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:28:36 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:28:31 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:26:39 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:26:34 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:23:55 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:23:50 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:22:06 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:22:01 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:19:21 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:19:16 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:17:20 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:17:14 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:15:28 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:15:24 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:13:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:13:37 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:10:48 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:10:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:08:33 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:08:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:05:58 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:05:53 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:04:09 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:04:04 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:02:27 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:02:19 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:00:54 AMDone
SEJ (?)TAPThursday 14th of March 2019 02:00:41 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:55:56 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:55:49 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:54:10 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:54:03 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:52:14 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:52:10 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:50:25 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:50:20 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:48:13 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:48:07 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:46:24 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:46:09 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:44:02 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:43:57 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:41:46 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:41:39 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:39:06 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:38:59 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:37:20 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:37:13 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:35:24 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:35:18 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:30:23 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:30:17 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:28:31 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:28:25 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:26:34 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:26:29 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:24:57 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:24:48 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:14:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:14:31 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:10:53 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:10:47 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:09:19 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:09:15 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:07:00 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:06:55 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:04:54 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:04:49 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:02:51 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:02:42 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:00:32 AMDone
SEJ (?)TAPThursday 14th of March 2019 01:00:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:55:56 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:55:52 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:45:57 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:45:49 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:44:11 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:44:07 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:42:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:42:23 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:40:40 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:40:35 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:37:24 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:37:19 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:34:41 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:34:36 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:32:45 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:32:40 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:30:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:30:17 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:28:35 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:28:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:25:56 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:25:49 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:24:27 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:24:19 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:22:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:22:31 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:18:38 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:18:28 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:16:36 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:16:26 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:15:36 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:14:05 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:12:45 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:11:22 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:09:09 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:08:13 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:06:54 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:06:43 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:04:45 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:04:18 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:04:04 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:02:02 AMDone
SEJ (?)TAPThursday 14th of March 2019 12:01:54 AMDone
SEJ (?)TAPWednesday 13th of March 2019 11:56:31 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:55:09 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:53:43 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:52:31 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:50:30 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:49:18 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:47:46 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:45:16 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:43:51 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:41:53 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:39:56 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:38:23 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:36:12 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:34:53 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:33:03 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:27:30 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:23:42 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:22:14 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:20:57 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:19:37 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:18:16 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:16:14 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:14:44 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:12:30 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:09:25 PMDone
SEJ (?)TAPWednesday 13th of March 2019 11:02:35 PMDone
SEJ (?)TAPWednesday 13th of March 2019 03:41:43 PMDone
SEJ (?)TAPWednesday 13th of March 2019 12:16:57 PMDone
SEJ (?)TAPWednesday 13th of March 2019 12:12:44 PMDone
SEJ (?)TAPWednesday 13th of March 2019 02:39:06 AMDone
SEJ (?)TAPWednesday 13th of March 2019 02:38:59 AMDone
SEJ (?)TAPWednesday 13th of March 2019 02:37:00 AMDone
SEJ (?)TAPWednesday 13th of March 2019 02:36:28 AMDone
SEJ (?)TAPWednesday 13th of March 2019 12:12:51 AMDone
SEJ (?)TAPWednesday 13th of March 2019 12:09:28 AMDone