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Summary of Results
Five TAP Developability Guidelines
PSH Metric = Patches of Surface Hydrophobicity Metric; PPC Metric = Patches of Positive Charge Metric; PNC Metric = Patches of Negative Charge Metric; SFvCSP = Structural Fv Charge Symmetry Parameter. Formulae for each metric are provided in the TAP paper.
The following histograms show where your antibody sits within the 5 TAP metric distributions of the 242 clinical-stage therapeutics referenced in the TAP paper.
Amber and red flag cutoffs are shown by the appropriately-coloured dashed lines, and the value recorded for your antibody is the solid line, coloured by assigned flag.
Metric 1: Total CDR Length
Metric 2: PSH Score
Metric 3: PPC Score
Metric 4: PNC Score
Metric 5: SFvCSP Score
The CDR Vicinity encompasses all surface-exposed IMGT CDR and anchor residues, as well as other surface exposed residues with at least one heavy atom within a radius of 4Å. This means that some IMGT CDR residues may not be highlighted (insufficient exposure, < 7.5% relative to Ala-X-Ala for any residue X), whilst some residues outside the IMGT CDR definitions may be highlighted.
Model Accuracy & Sequence Liabilities
Canonical Form Usage
Below are the predicted North-defined length-independent canonical forms for each non-CDRH3 loop in your model structure:
(UC: Unclustered; Template Untested: We have not yet assigned this template a canonical form (will be a recent PDB deposition). This will be included in the next monthly update)
Click here to view and download the distributions of canonical forms seen across the human Ig-seq models in the TAP paper.
|File Download Link||File Description|
|Model Structure||ABodyBuilder model for your antibody (IMGT-numbered). Note this was made ensuring no sequence identical templates - if there was a PDB structure for this antibody, it will not be reproduced. For the protocol which allows sequence identical templates, please use ABodyBuilder.|
Please see the help page for further explanation of the results.