Details for 2p1y

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Structure information

1.B2.D9, a Bispecific alpha/Beta TCR

Item	Info
PDB	2p1y
Organism	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	2.42Å
Number of TCRs	4

Paired chains information

This PDB has 4 TCR(s).

A / c

TCR Details:

Item	Info
VB chain	A
VA chain	c
VB IMGT details	TRBV13/TRBJ1
VA IMGT details	TRAV14/TRAJ30
Species	mouse

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
M	A	V	T	Q	S	P	R
B10	B11	B12	B13	B14	B15	B16	B17
N	K	V	A	V	T	G	G
B18	B19	B20	B21	B22	B23	B24	B25
K	V	T	L	S	C	N	Q
B26	B27	B28	B29	B37	B38	B39	B40
T	N	N	H	N	N	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	T	G	H
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	H	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Y	G	A	G	S	T	E	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	P	D	G	Y	K
B78	B79	B80	B81	B83	B84	B85	B86
A	S	R	P	S	Q	E	N
B87	B88	B89	B90	B91	B92	B93	B94
F	S	L	I	L	E	L	A
B95	B96	B97	B98	B99	B100	B101	B102
T	P	S	Q	T	S	V	Y
B103	B104	B105	B106	B107	B108	B109	B110
F	C	A	S	G	D	L	G
B111	B112	B113	B114	B115	B116	B117	B118
Q	T	N	E	R	L	F	F
B119	B120	B121	B122	B123	B124	B125	B126
G	H	G	T	K	L	S	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
D	G	Q	V	R	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
Q	S	L	T	V	W	E	G
A17	A18	A19	A20	A21	A22	A23	A24
E	T	A	I	L	N	C	S
A25	A26	A27	A28	A29	A36	A37	A38
Y	E	N	S	A	F	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
G	E	G	P	A	L	L	I
A55	A56	A57	A58	A59	A63	A64	A65
S	I	L	S	V	S	D	K
A66	A67	A68	A74	A75	A76	A77	A78
K	E	D	G	R	F	T	I
A79	A80	A81	A82	A83	A84	A85	A86
F	F	N	K	R	E	K	K
A87	A88	A89	A90	A91	A92	A93	A94
L	S	L	H	I	A	D	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	G	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	I	D	T	N
A113	A114	A115	A116	A117	A118	A119	A120
A	Y	K	V	I	F	G	K
A121	A122	A123	A124	A125	A126	A127	A128
G	T	H	L	H	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGDLGQTNERLF	None	13
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AAIDTNAYKVI	None	11
CDRA2	ILSVSDK	None	7
CDRA1	NSAFDY	None	6

Orientation and docking angles:

Angle	Value
BC2	103.78°
BC1	71.14°
BA	-59.22°
AC2	76.19°
AC1	126.48°
dc	17.18Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
6c09_DC	104.72°	69.41°	-59.07°	75.75°	126.51°	16.63Å	2.1
4x6c_HG	103.89°	71.32°	-59.69°	77.11°	123.97°	16.76Å	2.8
6vtc_BA	104.26°	70.42°	-59.69°	74.76°	124.13°	17.34Å	2.9
7pb2_JI	103.13°	73.39°	-57.79°	76.91°	125.64°	16.86Å	3.0
2vlm_ED	103.50°	69.83°	-61.60°	77.12°	125.51°	16.55Å	3.1

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	8.8
4x4x_CD	112.33°	72.96°	-60.80°	78.66°	125.88°	15.67Å	9.4
3bgf_BC	109.96°	71.90°	-55.10°	81.62°	123.51°	15.76Å	9.8
1cfq_BA	106.86°	67.47°	-56.63°	80.83°	119.58°	16.37Å	10.0

C / a

TCR Details:

Item	Info
VB chain	C
VA chain	a
VB IMGT details	TRBV13/TRBJ1
VA IMGT details	TRAV14/TRAJ30
Species	mouse

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
M	A	V	T	Q	S	P	R
B10	B11	B12	B13	B14	B15	B16	B17
N	K	V	A	V	T	G	G
B18	B19	B20	B21	B22	B23	B24	B25
K	V	T	L	S	C	N	Q
B26	B27	B28	B29	B37	B38	B39	B40
T	N	N	H	N	N	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	T	G	H
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	H	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Y	G	A	G	S	T	E	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	P	D	G	Y	K
B78	B79	B80	B81	B83	B84	B85	B86
A	S	R	P	S	Q	E	N
B87	B88	B89	B90	B91	B92	B93	B94
F	S	L	I	L	E	L	A
B95	B96	B97	B98	B99	B100	B101	B102
T	P	S	Q	T	S	V	Y
B103	B104	B105	B106	B107	B108	B109	B110
F	C	A	S	G	D	L	G
B111	B112	B113	B114	B115	B116	B117	B118
Q	T	N	E	R	L	F	F
B119	B120	B121	B122	B123	B124	B125	B126
G	H	G	T	K	L	S	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
D	G	Q	V	R	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
Q	S	L	T	V	W	E	G
A17	A18	A19	A20	A21	A22	A23	A24
E	T	A	I	L	N	C	S
A25	A26	A27	A28	A29	A36	A37	A38
Y	E	N	S	A	F	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
G	E	G	P	A	L	L	I
A55	A56	A57	A58	A59	A63	A64	A65
S	I	L	S	V	S	D	K
A66	A67	A68	A74	A75	A76	A77	A78
K	E	D	G	R	F	T	I
A79	A80	A81	A82	A83	A84	A85	A86
F	F	N	K	R	E	K	K
A87	A88	A89	A90	A91	A92	A93	A94
L	S	L	H	I	A	D	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	G	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	I	D	T	N
A113	A114	A115	A116	A117	A118	A119	A120
A	Y	K	V	I	F	G	K
A121	A122	A123	A124	A125	A126	A127	A128
G	T	H	L	H	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGDLGQTNERLF	None	13
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AAIDTNAYKVI	None	11
CDRA2	ILSVSDK	None	7
CDRA1	NSAFDY	None	6

Orientation and docking angles:

Angle	Value
BC2	103.29°
BC1	71.37°
BA	-59.08°
AC2	76.12°
AC1	126.47°
dc	17.20Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
6c09_DC	104.72°	69.41°	-59.07°	75.75°	126.51°	16.63Å	2.5
7pb2_JI	103.13°	73.39°	-57.79°	76.91°	125.64°	16.86Å	2.7
4x6c_HG	103.89°	71.32°	-59.69°	77.11°	123.97°	16.76Å	2.9
6c68_BA	104.25°	73.60°	-59.06°	74.52°	125.37°	16.75Å	3.1
3qdm_ED	102.30°	71.90°	-57.58°	76.51°	124.15°	16.66Å	3.1

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	9.0
4x4x_CD	112.33°	72.96°	-60.80°	78.66°	125.88°	15.67Å	9.8

E / e

TCR Details:

Item	Info
VB chain	E
VA chain	e
VB IMGT details	TRBV13/TRBJ1
VA IMGT details	TRAV14/TRAJ30
Species	mouse

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
M	A	V	T	Q	S	P	R
B10	B11	B12	B13	B14	B15	B16	B17
N	K	V	A	V	T	G	G
B18	B19	B20	B21	B22	B23	B24	B25
K	V	T	L	S	C	N	Q
B26	B27	B28	B29	B37	B38	B39	B40
T	N	N	H	N	N	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	T	G	H
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	H	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Y	G	A	G	S	T	E	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	P	D	G	Y	K
B78	B79	B80	B81	B83	B84	B85	B86
A	S	R	P	S	Q	E	N
B87	B88	B89	B90	B91	B92	B93	B94
F	S	L	I	L	E	L	A
B95	B96	B97	B98	B99	B100	B101	B102
T	P	S	Q	T	S	V	Y
B103	B104	B105	B106	B107	B108	B109	B110
F	C	A	S	G	D	L	G
B111	B112	B113	B114	B115	B116	B117	B118
Q	T	N	E	R	L	F	F
B119	B120	B121	B122	B123	B124	B125	B126
G	H	G	T	K	L	S	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
D	G	Q	V	R	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
Q	S	L	T	V	W	E	G
A17	A18	A19	A20	A21	A22	A23	A24
E	T	A	I	L	N	C	S
A25	A26	A27	A28	A29	A36	A37	A38
Y	E	N	S	A	F	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
G	E	G	P	A	L	L	I
A55	A56	A57	A58	A59	A63	A64	A65
S	I	L	S	V	S	D	K
A66	A67	A68	A74	A75	A76	A77	A78
K	E	D	G	R	F	T	I
A79	A80	A81	A82	A83	A84	A85	A86
F	F	N	K	R	E	K	K
A87	A88	A89	A90	A91	A92	A93	A94
L	S	L	H	I	A	D	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	G	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	I	D	T	N
A113	A114	A115	A116	A117	A118	A119	A120
A	Y	K	V	I	F	G	K
A121	A122	A123	A124	A125	A126	A127	A128
G	T	H	L	H	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGDLGQTNERLF	None	13
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AAIDTNAYKVI	None	11
CDRA2	ILSVSDK	None	7
CDRA1	NSAFDY	None	6

Orientation and docking angles:

Angle	Value
BC2	104.20°
BC1	69.26°
BA	-55.90°
AC2	73.75°
AC1	128.40°
dc	17.20Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
5w1w_ON	107.00°	70.84°	-56.72°	73.12°	128.77°	16.58Å	3.5
4zdh_BA	102.75°	70.60°	-53.65°	74.27°	126.61°	16.51Å	3.6
6cuh_BA	105.70°	69.71°	-56.90°	76.95°	129.69°	17.44Å	3.9
5w1v_TS	107.45°	71.42°	-56.95°	73.48°	128.04°	16.54Å	4.1
5w1w_JI	106.10°	70.74°	-54.96°	77.08°	128.55°	16.78Å	4.2

G / g

TCR Details:

Item	Info
VB chain	G
VA chain	g
VB IMGT details	TRBV13/TRBJ1
VA IMGT details	TRAV14/TRAJ30
Species	mouse

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
M	A	V	T	Q	S	P	R
B10	B11	B12	B13	B14	B15	B16	B17
N	K	V	A	V	T	G	G
B18	B19	B20	B21	B22	B23	B24	B25
K	V	T	L	S	C	N	Q
B26	B27	B28	B29	B37	B38	B39	B40
T	N	N	H	N	N	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	T	G	H
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	H	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Y	G	A	G	S	T	E	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	P	D	G	Y	K
B78	B79	B80	B81	B83	B84	B85	B86
A	S	R	P	S	Q	E	N
B87	B88	B89	B90	B91	B92	B93	B94
F	S	L	I	L	E	L	A
B95	B96	B97	B98	B99	B100	B101	B102
T	P	S	Q	T	S	V	Y
B103	B104	B105	B106	B107	B108	B109	B110
F	C	A	S	G	D	L	G
B111	B112	B113	B114	B115	B116	B117	B118
Q	T	N	E	R	L	F	F
B119	B120	B121	B122	B123	B124	B125	B126
G	H	G	T	K	L	S	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
D	G	Q	V	R	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
Q	S	L	T	V	W	E	G
A17	A18	A19	A20	A21	A22	A23	A24
E	T	A	I	L	N	C	S
A25	A26	A27	A28	A29	A36	A37	A38
Y	E	N	S	A	F	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
G	E	G	P	A	L	L	I
A55	A56	A57	A58	A59	A63	A64	A65
S	I	L	S	V	S	D	K
A66	A67	A68	A74	A75	A76	A77	A78
K	E	D	G	R	F	T	I
A79	A80	A81	A82	A83	A84	A85	A86
F	F	N	K	R	E	K	K
A87	A88	A89	A90	A91	A92	A93	A94
L	S	L	H	I	A	D	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	G	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	I	D	T	N
A113	A114	A115	A116	A117	A118	A119	A120
A	Y	K	V	I	F	G	K
A121	A122	A123	A124	A125	A126	A127	A128
G	T	H	L	H	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGDLGQTNERLF	None	13
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AAIDTNAYKVI	None	11
CDRA2	ILSVSDK	None	7
CDRA1	NSAFDY	None	6

Orientation and docking angles:

Angle	Value
BC2	104.08°
BC1	69.35°
BA	-55.78°
AC2	73.93°
AC1	128.57°
dc	17.19Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4zdh_BA	102.75°	70.60°	-53.65°	74.27°	126.61°	16.51Å	3.5
5w1w_ON	107.00°	70.84°	-56.72°	73.12°	128.77°	16.58Å	3.6
6cuh_BA	105.70°	69.71°	-56.90°	76.95°	129.69°	17.44Å	3.8
5w1w_JI	106.10°	70.74°	-54.96°	77.08°	128.55°	16.78Å	4.1
5w1v_TS	107.45°	71.42°	-56.95°	73.48°	128.04°	16.54Å	4.2

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link