Details for 7sg2

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Structure information

Xpa5 TCR in complex with HLA-Dq2-Omega1

Item	Info
PDB	7sg2
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.1Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

E / D

TCR Details:

Item	Info
VB chain	E
VA chain	D
VB IMGT details	TRBV29/TRBJ2
VA IMGT details	TRAV4/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	QPFPQPEQPFPGS
Antigen Length	13

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DQA10501 / HLA-DQB10201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
M	A	V	I	S	Q	K	P
B9	B10	B11	B12	B13	B14	B15	B16
S	R	D	I	C	Q	R	G
B17	B18	B19	B20	B21	B22	B23	B24
T	S	L	T	I	Q	C	Q
B25	B26	B27	B28	B29	B37	B38	B39
V	D	S	Q	V	T	M	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	Q	P	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	T	L	I	A	T
B56	B57	B58	B59	B63	B64	B65	B66
A	N	Q	G	S	E	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	S	G	F	V	I	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	P	I	S	R	P	N
B84	B85	B86	B87	B88	B89	B90	B91
L	T	F	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
S	N	M	S	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	I	Y	L	C	S	V	A
B108	B109	B110	B112	B113	B114	B115	B116
L	G	S	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A8	A9
H	M	K	T	T	Q	P	I
A10	A11	A12	A13	A14	A15	A16	A17
S	M	D	S	Y	E	G	Q
A18	A19	A20	A21	A22	A23	A24	A25
E	V	N	I	T	C	S	H
A26	A27	A28	A29	A30	A36	A37	A38
N	N	I	A	T	N	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
I	T	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
S	Q	G	P	R	F	I	I
A55	A56	A57	A58	A64	A65	A66	A67
Q	G	Y	K	T	K	V	T
A68	A74	A75	A76	A77	A78	A79	A80
N	E	V	A	S	L	F	I
A81	A82	A83	A84	A85	A86	A87	A88
P	A	D	R	K	S	S	T
A89	A90	A91	A92	A93	A94	A95	A96
L	S	L	P	R	V	S	L
A97	A98	A99	A100	A101	A102	A103	A104
S	D	T	A	V	Y	Y	C
A105	A106	A107	A108	A109	A113	A114	A115
L	V	G	G	L	A	R	D
A116	A117	A118	A119	A120	A121	A122	A123
M	R	F	G	A	G	T	R
A124	A125	A126	A127	A128
L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SVALGSDTGELF	None	12
CDRB2	ANQGSEA	None	7
CDRB1	SQVTM	None	5
CDRA3	LVGGLARDMR	None	10
CDRA2	GYKTK	None	5
CDRA1	NIATNDY	None	7

Orientation and docking angles:

Angle	Value
BC2	106.67°
BC1	69.23°
BA	-53.38°
AC2	88.19°
AC1	132.97°
dc	18.09Å
Docking angle	36.81°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
7sg1_ED	108.08°	69.88°	-51.96°	88.28°	133.28°	18.06Å	2.1
3o6f_HG	104.58°	69.75°	-54.07°	87.97°	132.76°	17.81Å	2.3
3t0e_DC	104.85°	71.10°	-52.97°	88.52°	133.53°	17.82Å	2.7
3pqy_JI	107.68°	69.73°	-56.20°	90.17°	132.20°	18.07Å	3.7
3pqy_ON	107.82°	69.20°	-57.40°	90.47°	131.73°	18.14Å	4.9

J / I

TCR Details:

Item	Info
VB chain	J
VA chain	I
VB IMGT details	TRBV29/TRBJ2
VA IMGT details	TRAV4/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	H
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	QPFPQPEQPFPGS
Antigen Length	13

MHC details:

Item	Info
MHC Chain	F \| G
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DQA10501 / HLA-DQB10201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
M	A	V	I	S	Q	K	P
B9	B10	B11	B12	B13	B14	B15	B16
S	R	D	I	C	Q	R	G
B17	B18	B19	B20	B21	B22	B23	B24
T	S	L	T	I	Q	C	Q
B25	B26	B27	B28	B29	B37	B38	B39
V	D	S	Q	V	T	M	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	Q	P	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	T	L	I	A	T
B56	B57	B58	B59	B63	B64	B65	B66
A	N	Q	G	S	E	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	S	G	F	V	I	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	P	I	S	R	P	N
B84	B85	B86	B87	B88	B89	B90	B91
L	T	F	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
S	N	M	S	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	I	Y	L	C	S	V	A
B108	B109	B110	B112	B113	B114	B115	B116
L	G	S	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A8	A9
H	M	K	T	T	Q	P	I
A10	A11	A12	A13	A14	A15	A16	A17
S	M	D	S	Y	E	G	Q
A18	A19	A20	A21	A22	A23	A24	A25
E	V	N	I	T	C	S	H
A26	A27	A28	A29	A30	A36	A37	A38
N	N	I	A	T	N	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
I	T	W	Y	Q	Q	F	P
A47	A48	A49	A50	A51	A52	A53	A54
S	Q	G	P	R	F	I	I
A55	A56	A57	A58	A64	A65	A66	A67
Q	G	Y	K	T	K	V	T
A68	A74	A75	A76	A77	A78	A79	A80
N	E	V	A	S	L	F	I
A81	A82	A83	A84	A85	A86	A87	A88
P	A	D	R	K	S	S	T
A89	A90	A91	A92	A93	A94	A95	A96
L	S	L	P	R	V	S	L
A97	A98	A99	A100	A101	A102	A103	A104
S	D	T	A	V	Y	Y	C
A105	A106	A107	A108	A109	A113	A114	A115
L	V	G	G	L	A	R	D
A116	A117	A118	A119	A120	A121	A122	A123
M	R	F	G	A	G	T	R
A124	A125	A126	A127	A128
L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SVALGSDTGELF	None	12
CDRB2	ANQGSEA	None	7
CDRB1	SQVTM	None	5
CDRA3	LVGGLARDMR	None	10
CDRA2	GYKTK	None	5
CDRA1	NIATNDY	None	7

Orientation and docking angles:

Angle	Value
BC2	108.94°
BC1	69.01°
BA	-46.77°
AC2	89.54°
AC1	135.13°
dc	18.66Å
Docking angle	34.51°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
7sg1_JI	109.49°	69.06°	-46.69°	89.50°	134.33°	18.62Å	1.0
2eys_BA	105.18°	68.91°	-48.08°	87.29°	132.33°	17.71Å	5.4
7sg1_ED	108.08°	69.88°	-51.96°	88.28°	133.28°	18.06Å	5.8
2eyr_BA	105.43°	68.62°	-46.73°	86.93°	131.51°	17.76Å	5.8
7t2c_ED	104.92°	66.74°	-49.42°	86.71°	135.06°	18.39Å	6.0

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link