Details for 8eo8

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Structure information

Cross-Reactive 3180 TCR Recognition of HLA-B*35:01-Np8 Epitope From 2005 H1N1 influenza Strain

Item	Info
PDB	8eo8
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.3Å
Number of TCRs	4

Paired chains information

This PDB has 4 TCR(s).

E / D

TCR Details:

Item	Info
VB chain	E
VA chain	D
VB IMGT details	TRBV20/TRBJ2
VA IMGT details	TRAV13/TRAJ28
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	INFLUENZA A VIRUS
Antigen Sequence	LPFDKATIM
Antigen Length	9

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-B*3501

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
A	V	V	S	Q	H	P	S
B10	B11	B12	B13	B14	B15	B16	B17
R	V	I	C	K	S	G	T
B18	B19	B20	B21	B22	B23	B24	B25
S	V	K	I	E	C	R	S
B26	B27	B28	B29	B36	B37	B38	B39
L	D	F	Q	A	T	T	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	F	P	K
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	M	L	M	A	T
B56	B57	B58	B59	B63	B64	B65	B66
S	N	E	G	S	K	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	Q	G	V	E	K	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	L	I	N	H	A	S
B84	B85	B86	B87	B88	B89	B90	B91
L	T	L	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
T	S	A	H	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	F	Y	I	C	S	A	G
B108	B109	B110	B111	B112	B113	B114	B115
P	T	S	G	R	T	D	T
B116	B117	B118	B119	B120	B121	B122	B123
Q	Y	F	G	P	G	T	R
B124	B125	B126	B127
L	T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
G	E	N	V	E	Q	H	P
A9	A10	A11	A12	A13	A14	A15	A16
S	T	L	S	V	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
D	S	A	V	I	K	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	D	S	A	S	N	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	K	Q	E	L
A47	A48	A49	A50	A51	A52	A53	A54
G	K	R	P	Q	L	I	I
A55	A56	A57	A58	A59	A63	A64	A65
D	I	R	S	N	V	G	E
A66	A67	A68	A74	A75	A76	A77	A78
K	K	D	Q	R	I	A	V
A79	A80	A81	A82	A83	A84	A85	A86
T	L	N	K	T	A	K	H
A87	A88	A89	A90	A91	A92	A93	A94
F	S	L	H	I	T	E	T
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	E	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	D	G	G	A
A112	A113	A114	A115	A116	A117	A118	A119
G	S	Y	Q	L	T	F	G
A120	A121	A122	A123	A124	A125	A126	A127
K	G	T	K	L	S	V	I
A128
P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SAGPTSGRTDTQY	None	13
CDRB2	SNEGSKA	None	7
CDRB1	DFQATT	None	6
CDRA3	AADGGAGSYQLT	None	12
CDRA2	IRSNVGE	None	7
CDRA1	DSASNY	None	6

Orientation and docking angles:

Angle	Value
BC2	99.44°
BC1	67.05°
BA	-46.51°
AC2	81.67°
AC1	128.90°
dc	17.38Å
Docking angle	41.53°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
8enh_ED	99.71°	67.01°	-46.00°	81.48°	129.32°	17.41Å	0.7
8enh_JI	100.05°	66.85°	-46.52°	81.14°	129.31°	17.53Å	0.9
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	1.0
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	1.6
8en8_ED	99.32°	66.55°	-48.01°	80.60°	128.61°	17.34Å	1.9

J / I

TCR Details:

Item	Info
VB chain	J
VA chain	I
VB IMGT details	TRBV20/TRBJ2
VA IMGT details	TRAV13/TRAJ28
Species	human

Antigen Details:

Item	Info
Antigen Chain	H
Antigen Type	Peptide
Antigen Organism	INFLUENZA A VIRUS
Antigen Sequence	LPFDKATIM
Antigen Length	9

MHC details:

Item	Info
MHC Chain	F \| G
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-B*3501

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
A	V	V	S	Q	H	P	S
B10	B11	B12	B13	B14	B15	B16	B17
R	V	I	C	K	S	G	T
B18	B19	B20	B21	B22	B23	B24	B25
S	V	K	I	E	C	R	S
B26	B27	B28	B29	B36	B37	B38	B39
L	D	F	Q	A	T	T	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	F	P	K
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	M	L	M	A	T
B56	B57	B58	B59	B63	B64	B65	B66
S	N	E	G	S	K	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	Q	G	V	E	K	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	L	I	N	H	A	S
B84	B85	B86	B87	B88	B89	B90	B91
L	T	L	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
T	S	A	H	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	F	Y	I	C	S	A	G
B108	B109	B110	B111	B112	B113	B114	B115
P	T	S	G	R	T	D	T
B116	B117	B118	B119	B120	B121	B122	B123
Q	Y	F	G	P	G	T	R
B124	B125	B126	B127
L	T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
G	E	N	V	E	Q	H	P
A9	A10	A11	A12	A13	A14	A15	A16
S	T	L	S	V	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
D	S	A	V	I	K	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	D	S	A	S	N	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	K	Q	E	L
A47	A48	A49	A50	A51	A52	A53	A54
G	K	R	P	Q	L	I	I
A55	A56	A57	A58	A59	A63	A64	A65
D	I	R	S	N	V	G	E
A66	A67	A68	A74	A75	A76	A77	A78
K	K	D	Q	R	I	A	V
A79	A80	A81	A82	A83	A84	A85	A86
T	L	N	K	T	A	K	H
A87	A88	A89	A90	A91	A92	A93	A94
F	S	L	H	I	T	E	T
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	E	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	D	G	G	A
A112	A113	A114	A115	A116	A117	A118	A119
G	S	Y	Q	L	T	F	G
A120	A121	A122	A123	A124	A125	A126	A127
K	G	T	K	L	S	V	I
A128
P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SAGPTSGRTDTQY	None	13
CDRB2	SNEGSKA	None	7
CDRB1	DFQATT	None	6
CDRA3	AADGGAGSYQLT	None	12
CDRA2	IRSNVGE	None	7
CDRA1	DSASNY	None	6

Orientation and docking angles:

Angle	Value
BC2	99.78°
BC1	66.91°
BA	-47.34°
AC2	81.05°
AC1	128.79°
dc	17.46Å
Docking angle	42.29°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
8en8_ED	99.32°	66.55°	-48.01°	80.60°	128.61°	17.34Å	1.0
8enh_JI	100.05°	66.85°	-46.52°	81.14°	129.31°	17.53Å	1.0
8enh_ED	99.71°	67.01°	-46.00°	81.48°	129.32°	17.41Å	1.5
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	1.8
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	2.5

O / N

TCR Details:

Item	Info
VB chain	O
VA chain	N
VB IMGT details	TRBV20/TRBJ2
VA IMGT details	TRAV13/TRAJ28
Species	human

Antigen Details:

Item	Info
Antigen Chain	M
Antigen Type	Peptide
Antigen Organism	INFLUENZA A VIRUS
Antigen Sequence	LPFDKATIM
Antigen Length	9

MHC details:

Item	Info
MHC Chain	K \| L
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-B*3501

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
A	V	V	S	Q	H	P	S
B10	B11	B12	B13	B14	B15	B16	B17
R	V	I	C	K	S	G	T
B18	B19	B20	B21	B22	B23	B24	B25
S	V	K	I	E	C	R	S
B26	B27	B28	B29	B36	B37	B38	B39
L	D	F	Q	A	T	T	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	F	P	K
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	M	L	M	A	T
B56	B57	B58	B59	B63	B64	B65	B66
S	N	E	G	S	K	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	Q	G	V	E	K	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	L	I	N	H	A	S
B84	B85	B86	B87	B88	B89	B90	B91
L	T	L	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
T	S	A	H	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	F	Y	I	C	S	A	G
B108	B109	B110	B111	B112	B113	B114	B115
P	T	S	G	R	T	D	T
B116	B117	B118	B119	B120	B121	B122	B123
Q	Y	F	G	P	G	T	R
B124	B125	B126	B127
L	T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
G	E	N	V	E	Q	H	P
A9	A10	A11	A12	A13	A14	A15	A16
S	T	L	S	V	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
D	S	A	V	I	K	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	D	S	A	S	N	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	K	Q	E	L
A47	A48	A49	A50	A51	A52	A53	A54
G	K	R	P	Q	L	I	I
A55	A56	A57	A58	A59	A63	A64	A65
D	I	R	S	N	V	G	E
A66	A67	A68	A74	A75	A76	A77	A78
K	K	D	Q	R	I	A	V
A79	A80	A81	A82	A83	A84	A85	A86
T	L	N	K	T	A	K	H
A87	A88	A89	A90	A91	A92	A93	A94
F	S	L	H	I	T	E	T
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	E	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	D	G	G	A
A112	A113	A114	A115	A116	A117	A118	A119
G	S	Y	Q	L	T	F	G
A120	A121	A122	A123	A124	A125	A126	A127
K	G	T	K	L	S	V	I
A128
P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SAGPTSGRTDTQY	None	13
CDRB2	SNEGSKA	None	7
CDRB1	DFQATT	None	6
CDRA3	AADGGAGSYQLT	None	12
CDRA2	IRSNVGE	None	7
CDRA1	DSASNY	None	6

Orientation and docking angles:

Angle	Value
BC2	99.21°
BC1	66.73°
BA	-47.23°
AC2	81.93°
AC1	129.12°
dc	17.51Å
Docking angle	42.46°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	1.0
8enh_JI	100.05°	66.85°	-46.52°	81.14°	129.31°	17.53Å	1.4
8enh_ED	99.71°	67.01°	-46.00°	81.48°	129.32°	17.41Å	1.4
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	1.5
8en8_ED	99.32°	66.55°	-48.01°	80.60°	128.61°	17.34Å	1.6

T / S

TCR Details:

Item	Info
VB chain	T
VA chain	S
VB IMGT details	TRBV20/TRBJ2
VA IMGT details	TRAV13/TRAJ28
Species	human

Antigen Details:

Item	Info
Antigen Chain	R
Antigen Type	Peptide
Antigen Organism	INFLUENZA A VIRUS
Antigen Sequence	LPFDKATIM
Antigen Length	9

MHC details:

Item	Info
MHC Chain	P \| Q
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-B*3501

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
A	V	V	S	Q	H	P	S
B10	B11	B12	B13	B14	B15	B16	B17
R	V	I	C	K	S	G	T
B18	B19	B20	B21	B22	B23	B24	B25
S	V	K	I	E	C	R	S
B26	B27	B28	B29	B36	B37	B38	B39
L	D	F	Q	A	T	T	M
B40	B41	B42	B43	B44	B45	B46	B47
F	W	Y	R	Q	F	P	K
B48	B49	B50	B51	B52	B53	B54	B55
Q	S	L	M	L	M	A	T
B56	B57	B58	B59	B63	B64	B65	B66
S	N	E	G	S	K	A	T
B67	B68	B69	B70	B71	B72	B73	B74
Y	E	Q	G	V	E	K	D
B75	B76	B77	B78	B79	B80	B81	B83
K	F	L	I	N	H	A	S
B84	B85	B86	B87	B88	B89	B90	B91
L	T	L	S	T	L	T	V
B92	B93	B94	B95	B96	B97	B98	B99
T	S	A	H	P	E	D	S
B100	B101	B102	B103	B104	B105	B106	B107
S	F	Y	I	C	S	A	G
B108	B109	B110	B111	B112	B113	B114	B115
P	T	S	G	R	T	D	T
B116	B117	B118	B119	B120	B121	B122	B123
Q	Y	F	G	P	G	T	R
B124	B125	B126	B127
L	T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
G	E	N	V	E	Q	H	P
A9	A10	A11	A12	A13	A14	A15	A16
S	T	L	S	V	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
D	S	A	V	I	K	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	D	S	A	S	N	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	P	W	Y	K	Q	E	L
A47	A48	A49	A50	A51	A52	A53	A54
G	K	R	P	Q	L	I	I
A55	A56	A57	A58	A59	A63	A64	A65
D	I	R	S	N	V	G	E
A66	A67	A68	A74	A75	A76	A77	A78
K	K	D	Q	R	I	A	V
A79	A80	A81	A82	A83	A84	A85	A86
T	L	N	K	T	A	K	H
A87	A88	A89	A90	A91	A92	A93	A94
F	S	L	H	I	T	E	T
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	E	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A110
F	C	A	A	D	G	G	A
A112	A113	A114	A115	A116	A117	A118	A119
G	S	Y	Q	L	T	F	G
A120	A121	A122	A123	A124	A125	A126	A127
K	G	T	K	L	S	V	I
A128
P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	SAGPTSGRTDTQY	None	13
CDRB2	SNEGSKA	None	7
CDRB1	DFQATT	None	6
CDRA3	AADGGAGSYQLT	None	12
CDRA2	IRSNVGE	None	7
CDRA1	DSASNY	None	6

Orientation and docking angles:

Angle	Value
BC2	98.73°
BC1	66.45°
BA	-47.32°
AC2	82.04°
AC1	129.10°
dc	17.47Å
Docking angle	42.37°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	1.3
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	1.4
8en8_ED	99.32°	66.55°	-48.01°	80.60°	128.61°	17.34Å	1.8
8enh_JI	100.05°	66.85°	-46.52°	81.14°	129.31°	17.53Å	1.8
8enh_ED	99.71°	67.01°	-46.00°	81.48°	129.32°	17.41Å	1.8

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link