Details for 4z7v

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Structure information

L3-12 complex

Item	Info
PDB	4z7v
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.65Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

F / E

TCR Details:

Item	Info
VB chain	F
VA chain	E
VB IMGT details	TRBV9/TRBJ2
VA IMGT details	TRAV26/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	I
Antigen Type	Peptide
Antigen Organism	TRITICUM AESTIVUM
Antigen Sequence	APSGEGSFQPSQENPQGS
Antigen Length	18

MHC details:

Item	Info
MHC Chain	C \| D
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DQA10301 / HLA-DQB10302

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
D	S	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	H	L	I	T	A	T	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	R	V	T	L	R	C	S
B25	B26	B27	B28	B29	B37	B38	B39
P	R	S	G	D	L	S	V
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	S	L	D
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	L	Q	F	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
Y	Y	N	G	E	E	R	A
B68	B69	B70	B71	B72	B74	B75	B76
K	G	N	I	L	E	R	F
B77	B78	B79	B80	B81	B83	B84	B85
S	A	Q	Q	F	P	D	L
B86	B87	B88	B89	B90	B91	B92	B93
H	S	E	L	N	L	S	S
B94	B95	B96	B97	B98	B99	B100	B101
L	E	L	G	D	S	A	L
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	S	A	G
B110	B111	B112	B113	B114	B115	B116	B117
T	S	G	E	Y	E	Q	Y
B118	B119	B120	B121	B122	B123	B124	B125
F	G	P	G	T	R	L	T
B126	B127
V	T

FASTA file

A1	A2	A3	A4	A5	A6	A8	A9
D	A	K	T	T	Q	P	N
A10	A11	A12	A13	A14	A15	A16	A17
S	M	E	S	N	E	E	E
A18	A19	A20	A21	A22	A23	A24	A25
P	V	H	L	P	C	N	H
A26	A27	A28	A29	A30	A36	A37	A38
S	T	I	S	G	T	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
I	H	W	Y	R	Q	L	P
A47	A48	A49	A50	A51	A52	A53	A54
S	Q	G	P	E	Y	V	I
A55	A56	A57	A58	A64	A65	A66	A67
H	G	L	T	S	N	V	N
A68	A74	A75	A76	A77	A78	A79	A80
N	R	M	A	S	L	A	I
A81	A82	A83	A84	A85	A86	A87	A88
A	E	D	R	K	S	S	T
A89	A90	A91	A92	A93	A94	A95	A96
L	I	L	H	R	A	T	L
A97	A98	A99	A100	A101	A102	A103	A104
R	D	A	A	V	Y	Y	C
A105	A106	A107	A108	A109	A110	A113	A114
I	L	R	D	S	R	A	Q
A115	A116	A117	A118	A119	A120	A121	A122
K	L	V	F	G	Q	G	T
A123	A124	A125	A126	A127	A128
R	L	T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSAGTSGEYEQY	None	13
CDRB2	YYNGEE	None	6
CDRB1	SGDLS	None	5
CDRA3	ILRDSRAQKLV	None	11
CDRA2	GLTSN	None	5
CDRA1	TISGTDY	None	7

Orientation and docking angles:

Angle	Value
BC2	111.26°
BC1	73.06°
BA	-61.69°
AC2	93.39°
AC1	131.70°
dc	17.14Å
Docking angle	39.67°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4gg6_HG	110.99°	73.29°	-63.02°	90.06°	131.30°	16.97Å	3.6
2esv_ED	107.82°	72.93°	-61.63°	93.92°	130.54°	17.31Å	3.7
4gg6_FE	111.17°	73.07°	-62.86°	89.77°	131.55°	16.94Å	3.8
3kpr_ED	108.37°	71.95°	-62.50°	91.08°	133.35°	17.66Å	4.3
7ndt_ED	107.81°	73.60°	-63.54°	93.10°	128.98°	17.20Å	4.8

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4jpw_HL	112.65°	71.66°	-58.66°	89.39°	123.36°	16.92Å	9.9

H / G

TCR Details:

Item	Info
VB chain	H
VA chain	G
VB IMGT details	TRBV9/TRBJ2
VA IMGT details	TRAV26/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	J
Antigen Type	Peptide
Antigen Organism	TRITICUM AESTIVUM
Antigen Sequence	APSGEGSFQPSQENPQGS
Antigen Length	18

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DQA10301 / HLA-DQB10302

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
D	S	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	H	L	I	T	A	T	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	R	V	T	L	R	C	S
B25	B26	B27	B28	B29	B37	B38	B39
P	R	S	G	D	L	S	V
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	S	L	D
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	L	Q	F	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
Y	Y	N	G	E	E	R	A
B68	B69	B70	B71	B72	B74	B75	B76
K	G	N	I	L	E	R	F
B77	B78	B79	B80	B81	B83	B84	B85
S	A	Q	Q	F	P	D	L
B86	B87	B88	B89	B90	B91	B92	B93
H	S	E	L	N	L	S	S
B94	B95	B96	B97	B98	B99	B100	B101
L	E	L	G	D	S	A	L
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	S	A	G
B110	B111	B112	B113	B114	B115	B116	B117
T	S	G	E	Y	E	Q	Y
B118	B119	B120	B121	B122	B123	B124	B125
F	G	P	G	T	R	L	T
B126	B127
V	T

FASTA file

A1	A2	A3	A4	A5	A6	A8	A9
D	A	K	T	T	Q	P	N
A10	A11	A12	A13	A14	A15	A16	A17
S	M	E	S	N	E	E	E
A18	A19	A20	A21	A22	A23	A24	A25
P	V	H	L	P	C	N	H
A26	A27	A28	A29	A30	A36	A37	A38
S	T	I	S	G	T	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
I	H	W	Y	R	Q	L	P
A47	A48	A49	A50	A51	A52	A53	A54
S	Q	G	P	E	Y	V	I
A55	A56	A57	A58	A64	A65	A66	A67
H	G	L	T	S	N	V	N
A68	A74	A75	A76	A77	A78	A79	A80
N	R	M	A	S	L	A	I
A81	A82	A83	A84	A85	A86	A87	A88
A	E	D	R	K	S	S	T
A89	A90	A91	A92	A93	A94	A95	A96
L	I	L	H	R	A	T	L
A97	A98	A99	A100	A101	A102	A103	A104
R	D	A	A	V	Y	Y	C
A105	A106	A107	A108	A109	A110	A113	A114
I	L	R	D	S	R	A	Q
A115	A116	A117	A118	A119	A120	A121	A122
K	L	V	F	G	Q	G	T
A123	A124	A125	A126	A127	A128
R	L	T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSAGTSGEYEQY	None	13
CDRB2	YYNGEE	None	6
CDRB1	SGDLS	None	5
CDRA3	ILRDSRAQKLV	None	11
CDRA2	GLTSN	None	5
CDRA1	TISGTDY	None	7

Orientation and docking angles:

Angle	Value
BC2	111.21°
BC1	73.03°
BA	-62.36°
AC2	92.92°
AC1	131.88°
dc	17.12Å
Docking angle	38.98°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4gg6_HG	110.99°	73.29°	-63.02°	90.06°	131.30°	16.97Å	3.0
4gg6_FE	111.17°	73.07°	-62.86°	89.77°	131.55°	16.94Å	3.2
3kpr_ED	108.37°	71.95°	-62.50°	91.08°	133.35°	17.66Å	3.9
2esv_ED	107.82°	72.93°	-61.63°	93.92°	130.54°	17.31Å	3.9
7ndt_ED	107.81°	73.60°	-63.54°	93.10°	128.98°	17.20Å	4.7

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link