Antibodies are an important component of the immune system and are increasingly used as therapeutics. Recent advances in protein structure modelling make it possible to accurately predict the structure of antibodies from their amino acid sequence. A limitation of current structure prediction tools is that they only predict the structure of a single conformation of an antibody.  However, antibodies are flexible molecules that frequently transition between a set of distinct structural conformations and flexibility is key to many functional properties. During my DPhil, I aim to develop antibody structure prediction tools that capture the flexibility of antibodies and predict the structure of multiple conformations.