High Resolution Modelling of Antibody Structures
My research focuses on studying and predicting the structure of the framework regions of antibody variable domains (VH and VL). The specificity of an antibody for a particular antigen is largely determined by hyper-variable loops (CDRs). However the structure of the framework which they are mounted upon is also thought to be important in determining antibody-antigen affinity. I aim to produce high resolution models of antibody molecules and study how the relative orientation of the variable domains affects the antigen binding site.