A fragment screen offers an information rich starting point for derivative compounds that can recapitulate fragment interactions. I am interested in how to maximally explore the fragment merge-design space with in silico design. By prioritizing synthetic tractability, fragment derivate designs can be synthesized via high-throughput multi-step chemistry reducing the overall cost and time to experimentally test them. In collaboration with XChem at Diamond Light source, I work directly with organic chemists and structural biologists to drive their fragment development projects forward.