Ideally, in drug discovery, once a target has been identified and characterised, it should be possible to efficiently and exhaustively search chemical space for bioactive molecules with specific physio-chemical properties. Recent progress in computational capabilities and machine- learning methods mean that De Novo molecular generation tools are a step toward the above ideal. In collaboration with Exscientia, my research will focus on further developing machine learning tools for molecular design. Subsequent work will involve the elucidation and development of chemical synthesis pathways that will enable us more effectively make new compounds to tackle disease.