I focus on structure-based drug design (SBDD) which uses 3D protein structures to design small molecules in a pocket-aware manner. My interest is primarily on the application of diffusion models in this space, which gradually add noise from molecular structures in three-dimensional space to generate novel compounds that match target protein binding sites. The goal is to generate molecules with high binding affinities to their targets which are synthetically accessible and chemically sound. I am interested in exploring the application of constraints on these models, new architectures for complex protein-ligand systems and the integration of a large language model to make these tools accessible to medicinal chemists.