HEADER VIRAL PROTEIN/IMMUNE SYSTEM 25-AUG-13 3WHE TITLE A NEW CONSERVED NEUTRALIZING EPITOPE AT THE GLOBULAR HEAD OF TITLE 2 HEMAGGLUTININ IN H3N2 INFLUENZA VIRUSES COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L; COMPND 4 FRAGMENT: UNP RESIDUES 25-517; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: IMMUNOGLOBULIN HEAVY CHAIN; COMPND 8 CHAIN: M, O, Q, S, U, W, Y, 1, 3, 5, 7, 9; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: IMMUNOGLOBULIN LIGHT CHAIN; COMPND 12 CHAIN: N, P, R, T, V, X, Z, 2, 4, 6, 8, 0; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 1391655; SOURCE 4 STRAIN: A/AICHI/2-1/1968 (H3N2); SOURCE 5 GENE: 126567434, HA; SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 7 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: SF+; SOURCE 10 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; SOURCE 11 EXPRESSION_SYSTEM_PLASMID: PBAC-3; SOURCE 12 MOL_ID: 2; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 17 EXPRESSION_SYSTEM_STRAIN: CHO-K1; SOURCE 18 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 19 EXPRESSION_SYSTEM_PLASMID: PCMVSCRIPT; SOURCE 20 OTHER_DETAILS: PROTEIN SELECTED BY PHAGE DISPLAY; SOURCE 21 MOL_ID: 3; SOURCE 22 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 25 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 26 EXPRESSION_SYSTEM_STRAIN: CHO-K1; SOURCE 27 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 28 EXPRESSION_SYSTEM_PLASMID: PCMVSCRIPT; SOURCE 29 OTHER_DETAILS: PROTEIN SELECTED BY PHAGE DISPLAY KEYWDS VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR Y.FUJII,T.SUMIDA,M.SHIROUZU,S.YOKOYAMA REVDAT 1 23-APR-14 3WHE 0 JRNL AUTH Y.IBA,Y.FUJII,N.OHSHIMA,T.SUMIDA,R.KUBOTA-KOKETSU,M.IKEDA, JRNL AUTH 2 M.WAKIYAMA,M.SHIROUZU,J.OKADA,Y.OKUNO,Y.KUROSAWA,S.YOKOYAMA JRNL TITL CONSERVED NEUTRALIZING EPITOPE AT GLOBULAR HEAD OF JRNL TITL 2 HEMAGGLUTININ IN H3N2 INFLUENZA VIRUSES. JRNL REF J.VIROL. 2014 JRNL REFN ESSN 1098-5514 JRNL PMID 24719430 JRNL DOI 10.1128/JVI.00420-14 REMARK 2 REMARK 2 RESOLUTION. 4.00 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : CNS REMARK 3 AUTHORS : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- REMARK 3 : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU, REMARK 3 : READ,RICE,SIMONSON,WARREN REMARK 3 REMARK 3 REFINEMENT TARGET : ENGH & HUBER REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 4.00 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 30.00 REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000 REMARK 3 DATA CUTOFF HIGH (ABS(F)) : 17247948.000 REMARK 3 DATA CUTOFF LOW (ABS(F)) : 0.0000 REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 98.1 REMARK 3 NUMBER OF REFLECTIONS : 142111 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING SET) : 0.235 REMARK 3 FREE R VALUE : 0.308 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.900 REMARK 3 FREE R VALUE TEST SET COUNT : 7106 REMARK 3 ESTIMATED ERROR OF FREE R VALUE : 0.004 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 10 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 4.00 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 4.14 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 94.40 REMARK 3 REFLECTIONS IN BIN (WORKING SET) : 12964 REMARK 3 BIN R VALUE (WORKING SET) : 0.3959 REMARK 3 BIN FREE R VALUE : 0.3972 REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : NULL REMARK 3 BIN FREE R VALUE TEST SET COUNT : 686 REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : NULL REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 85488 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 2664 REMARK 3 SOLVENT ATOMS : 0 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 205.85 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : 0.00000 REMARK 3 B22 (A**2) : 0.00000 REMARK 3 B33 (A**2) : 0.00000 REMARK 3 B12 (A**2) : 0.00000 REMARK 3 B13 (A**2) : 0.00000 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM LUZZATI PLOT (A) : 0.80 REMARK 3 ESD FROM SIGMAA (A) : 1.42 REMARK 3 LOW RESOLUTION CUTOFF (A) : 5.00 REMARK 3 REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : 0.80 REMARK 3 ESD FROM C-V SIGMAA (A) : 1.25 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. REMARK 3 BOND LENGTHS (A) : 0.004 REMARK 3 BOND ANGLES (DEGREES) : NULL REMARK 3 DIHEDRAL ANGLES (DEGREES) : NULL REMARK 3 IMPROPER ANGLES (DEGREES) : NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL MODEL : RESTRAINED REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA REMARK 3 MAIN-CHAIN BOND (A**2) : 7.443 ; 15.000 REMARK 3 MAIN-CHAIN ANGLE (A**2) : 11.536; 20.000 REMARK 3 SIDE-CHAIN BOND (A**2) : 11.616; 20.000 REMARK 3 SIDE-CHAIN ANGLE (A**2) : 16.938; 25.000 REMARK 3 REMARK 3 BULK SOLVENT MODELING. REMARK 3 METHOD USED : FLAT MODEL REMARK 3 KSOL : 0.30 REMARK 3 BSOL : 146.96 REMARK 3 REMARK 3 NCS MODEL : NULL REMARK 3 REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL REMARK 3 REMARK 3 PARAMETER FILE 1 : PROTEIN_REP.PARAM REMARK 3 PARAMETER FILE 2 : DNA-RNA_REP.PARAM REMARK 3 PARAMETER FILE 3 : WATER_REP.PARAM REMARK 3 PARAMETER FILE 4 : ION.PARAM REMARK 3 PARAMETER FILE 5 : CARBOHYDRATE.PARAM REMARK 3 PARAMETER FILE 6 : NULL REMARK 3 TOPOLOGY FILE 1 : PROTEIN.TOP REMARK 3 TOPOLOGY FILE 2 : DNA-RNA.TOP REMARK 3 TOPOLOGY FILE 3 : WATER.TOP REMARK 3 TOPOLOGY FILE 4 : ION.TOP REMARK 3 TOPOLOGY FILE 5 : CARBOHYDRATE.TOP REMARK 3 TOPOLOGY FILE 6 : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: BULK SOLVENT MODEL USED REMARK 4 REMARK 4 3WHE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 11-SEP-13. REMARK 100 THE RCSB ID CODE IS RCSB096337. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 22-OCT-11 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 5.5 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SPRING-8 REMARK 200 BEAMLINE : BL41XU REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.00 REMARK 200 MONOCHROMATOR : ROTATED-INCLINED DOUBLE-CRYSTAL REMARK 200 MONOCHROMATOR REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : CCD REMARK 200 DETECTOR MANUFACTURER : RAYONIX MX225HE REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : XSCALE REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 142111 REMARK 200 RESOLUTION RANGE HIGH (A) : 4.000 REMARK 200 RESOLUTION RANGE LOW (A) : 30.000 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : -3.000 REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 98.0 REMARK 200 DATA REDUNDANCY : 3.905 REMARK 200 R MERGE (I) : 0.23600 REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 6.3500 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.00 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 4.25 REMARK 200 COMPLETENESS FOR SHELL (%) : 98.1 REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : 0.02100 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 0.660 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASES REMARK 200 STARTING MODEL: 1HA0 REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 65.53 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.57 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: PEG8000, KCL, PH 5.5, VAPOR DIFFUSION, REMARK 280 SITTING DROP, TEMPERATURE 293K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y,-Z REMARK 290 3555 X+1/2,Y+1/2,Z REMARK 290 4555 -X+1/2,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 SMTRY1 3 1.000000 0.000000 0.000000 195.51850 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 120.58650 REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 4 -1.000000 0.000000 0.000000 195.51850 REMARK 290 SMTRY2 4 0.000000 1.000000 0.000000 120.58650 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 36-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, REMARK 350 AND CHAINS: J, K, L, M, O, Q, S, U, W, REMARK 350 AND CHAINS: Y, 1, 3, 5, 7, 9, N, P, R, REMARK 350 AND CHAINS: T, V, X, Z, 2, 4, 6, 8, 0 REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLN N 1 REMARK 465 THR N 214 REMARK 465 GLU N 215 REMARK 465 CYS N 216 REMARK 465 SER N 217 REMARK 465 ALA N 218 REMARK 465 ARG N 219 REMARK 465 GLN N 220 REMARK 465 GLN P 1 REMARK 465 THR P 214 REMARK 465 GLU P 215 REMARK 465 CYS P 216 REMARK 465 SER P 217 REMARK 465 ALA P 218 REMARK 465 ARG P 219 REMARK 465 GLN P 220 REMARK 465 GLN R 1 REMARK 465 THR R 214 REMARK 465 GLU R 215 REMARK 465 CYS R 216 REMARK 465 SER R 217 REMARK 465 ALA R 218 REMARK 465 ARG R 219 REMARK 465 GLN R 220 REMARK 465 GLN T 1 REMARK 465 THR T 214 REMARK 465 GLU T 215 REMARK 465 CYS T 216 REMARK 465 SER T 217 REMARK 465 ALA T 218 REMARK 465 ARG T 219 REMARK 465 GLN T 220 REMARK 465 GLN V 1 REMARK 465 THR V 214 REMARK 465 GLU V 215 REMARK 465 CYS V 216 REMARK 465 SER V 217 REMARK 465 ALA V 218 REMARK 465 ARG V 219 REMARK 465 GLN V 220 REMARK 465 GLN X 1 REMARK 465 THR X 214 REMARK 465 GLU X 215 REMARK 465 CYS X 216 REMARK 465 SER X 217 REMARK 465 ALA X 218 REMARK 465 ARG X 219 REMARK 465 GLN X 220 REMARK 465 GLN Z 1 REMARK 465 THR Z 214 REMARK 465 GLU Z 215 REMARK 465 CYS Z 216 REMARK 465 SER Z 217 REMARK 465 ALA Z 218 REMARK 465 ARG Z 219 REMARK 465 GLN Z 220 REMARK 465 GLN 2 1 REMARK 465 THR 2 214 REMARK 465 GLU 2 215 REMARK 465 CYS 2 216 REMARK 465 SER 2 217 REMARK 465 ALA 2 218 REMARK 465 ARG 2 219 REMARK 465 GLN 2 220 REMARK 465 GLN 4 1 REMARK 465 THR 4 214 REMARK 465 GLU 4 215 REMARK 465 CYS 4 216 REMARK 465 SER 4 217 REMARK 465 ALA 4 218 REMARK 465 ARG 4 219 REMARK 465 GLN 4 220 REMARK 465 GLN 6 1 REMARK 465 THR 6 214 REMARK 465 GLU 6 215 REMARK 465 CYS 6 216 REMARK 465 SER 6 217 REMARK 465 ALA 6 218 REMARK 465 ARG 6 219 REMARK 465 GLN 6 220 REMARK 465 GLN 8 1 REMARK 465 THR 8 214 REMARK 465 GLU 8 215 REMARK 465 CYS 8 216 REMARK 465 SER 8 217 REMARK 465 ALA 8 218 REMARK 465 ARG 8 219 REMARK 465 GLN 8 220 REMARK 465 GLN 0 1 REMARK 465 THR 0 214 REMARK 465 GLU 0 215 REMARK 465 CYS 0 216 REMARK 465 SER 0 217 REMARK 465 ALA 0 218 REMARK 465 ARG 0 219 REMARK 465 GLN 0 220 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 CB ALA 3 171 CB ALA 3 171 2556 1.73 REMARK 500 OG1 THR 3 206 OG1 THR 3 206 2556 1.74 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO N 114 C - N - CA ANGL. DEV. = 9.3 DEGREES REMARK 500 PRO R 114 C - N - CA ANGL. DEV. = 9.3 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ILE A 62 -137.08 39.48 REMARK 500 ALA A 93 164.33 -49.84 REMARK 500 PHE A 94 160.92 178.65 REMARK 500 GLU A 119 109.81 -53.45 REMARK 500 SER A 145 170.86 -56.51 REMARK 500 VAL A 163 107.54 -55.24 REMARK 500 ASN A 170 73.26 -106.66 REMARK 500 VAL A 196 -117.10 63.19 REMARK 500 ARG A 201 132.64 -174.15 REMARK 500 ARG A 208 -62.96 -104.89 REMARK 500 PRO A 221 124.20 -38.39 REMARK 500 ARG A 224 27.86 45.09 REMARK 500 GLU A 325 163.48 81.38 REMARK 500 ALA A 336 141.54 -32.46 REMARK 500 PHE A 338 -71.03 -40.48 REMARK 500 ILE A 339 -97.37 38.79 REMARK 500 GLU A 340 30.21 -98.70 REMARK 500 PHE A 392 -109.98 -124.15 REMARK 500 GLN A 394 -138.97 -133.36 REMARK 500 ARG A 456 -124.32 63.18 REMARK 500 ASN A 458 -32.73 -37.70 REMARK 500 ASN A 464 12.69 -68.52 REMARK 500 TYR A 486 137.08 -33.16 REMARK 500 VAL B 36 -169.63 -120.36 REMARK 500 ASN B 38 143.37 -170.53 REMARK 500 ILE B 62 -135.75 38.50 REMARK 500 PHE B 94 161.64 177.69 REMARK 500 ASN B 96 45.06 -140.04 REMARK 500 GLU B 119 109.38 -53.29 REMARK 500 CYS B 139 79.94 -119.53 REMARK 500 SER B 145 170.87 -54.68 REMARK 500 VAL B 163 107.76 -55.23 REMARK 500 ASN B 170 73.42 -106.24 REMARK 500 VAL B 196 -119.17 60.73 REMARK 500 GLN B 197 129.77 -38.83 REMARK 500 ARG B 201 131.86 -173.37 REMARK 500 ARG B 208 -63.08 -105.45 REMARK 500 PRO B 221 123.88 -38.47 REMARK 500 ARG B 224 27.45 44.05 REMARK 500 GLU B 325 163.31 80.27 REMARK 500 ALA B 336 141.94 -31.71 REMARK 500 PHE B 338 -70.07 -41.89 REMARK 500 ILE B 339 -96.17 38.33 REMARK 500 GLU B 340 30.00 -99.88 REMARK 500 PHE B 392 -110.57 -125.02 REMARK 500 GLN B 394 -136.17 -134.12 REMARK 500 ARG B 456 -124.66 61.95 REMARK 500 ASN B 458 -33.85 -37.86 REMARK 500 TYR B 486 136.50 -34.07 REMARK 500 ILE C 62 -138.96 34.44 REMARK 500 REMARK 500 THIS ENTRY HAS 559 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG A 608 BOUND REMARK 800 TO ASN A 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG A 618 BOUND REMARK 800 TO ASN A 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN B OF SUGAR BOUND TO ASN B REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG B 608 BOUND REMARK 800 TO ASN B 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN B OF SUGAR BOUND TO ASN B REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN B OF SUGAR BOUND TO ASN B REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG B 618 BOUND REMARK 800 TO ASN B 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN C OF SUGAR BOUND TO ASN C REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG C 608 BOUND REMARK 800 TO ASN C 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN C OF SUGAR BOUND TO ASN C REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN C OF SUGAR BOUND TO ASN C REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG C 618 BOUND REMARK 800 TO ASN C 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN D OF SUGAR BOUND TO ASN D REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG D 608 BOUND REMARK 800 TO ASN D 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: BC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN D OF SUGAR BOUND TO ASN D REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN D OF SUGAR BOUND TO ASN D REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG D 618 BOUND REMARK 800 TO ASN D 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN E OF SUGAR BOUND TO ASN E REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG E 608 BOUND REMARK 800 TO ASN E 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN E OF SUGAR BOUND TO ASN E REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN E OF SUGAR BOUND TO ASN E REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG E 618 BOUND REMARK 800 TO ASN E 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN F OF SUGAR BOUND TO ASN F REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: CC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG F 608 BOUND REMARK 800 TO ASN F 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN F OF SUGAR BOUND TO ASN F REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN F OF SUGAR BOUND TO ASN F REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG F 618 BOUND REMARK 800 TO ASN F 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN G OF SUGAR BOUND TO ASN G REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG G 608 BOUND REMARK 800 TO ASN G 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN G OF SUGAR BOUND TO ASN G REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN G OF SUGAR BOUND TO ASN G REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG G 618 BOUND REMARK 800 TO ASN G 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: DC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN H OF SUGAR BOUND TO ASN H REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG H 608 BOUND REMARK 800 TO ASN H 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN H OF SUGAR BOUND TO ASN H REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN H OF SUGAR BOUND TO ASN H REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG H 618 BOUND REMARK 800 TO ASN H 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN I OF SUGAR BOUND TO ASN I REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG I 608 BOUND REMARK 800 TO ASN I 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN I OF SUGAR BOUND TO ASN I REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN I OF SUGAR BOUND TO ASN I REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: EC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG I 618 BOUND REMARK 800 TO ASN I 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN J OF SUGAR BOUND TO ASN J REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG J 608 BOUND REMARK 800 TO ASN J 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN J OF SUGAR BOUND TO ASN J REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN J OF SUGAR BOUND TO ASN J REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG J 618 BOUND REMARK 800 TO ASN J 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN K OF SUGAR BOUND TO ASN K REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG K 608 BOUND REMARK 800 TO ASN K 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN K OF SUGAR BOUND TO ASN K REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: FC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN K OF SUGAR BOUND TO ASN K REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG K 618 BOUND REMARK 800 TO ASN K 483 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN L OF SUGAR BOUND TO ASN L REMARK 800 38 RESIDUES 615 TO 617 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG L 608 BOUND REMARK 800 TO ASN L 81 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN L OF SUGAR BOUND TO ASN L REMARK 800 165 RESIDUES 609 TO 614 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR CHAIN L OF SUGAR BOUND TO ASN L REMARK 800 285 RESIDUES 601 TO 607 REMARK 800 REMARK 800 SITE_IDENTIFIER: GC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE NAG L 618 BOUND REMARK 800 TO ASN L 483 DBREF 3WHE A 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE B 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE C 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE D 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE E 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE F 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE G 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE H 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE I 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE J 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE K 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE L 9 501 UNP T2HNI1 T2HNI1_9INFA 25 517 DBREF 3WHE M 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE O 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE Q 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE S 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE U 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE W 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE Y 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE 1 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE 3 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE 5 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE 7 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE 9 1 226 PDB 3WHE 3WHE 1 226 DBREF 3WHE N 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE P 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE R 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE T 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE V 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE X 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE Z 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE 2 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE 4 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE 6 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE 8 1 220 PDB 3WHE 3WHE 1 220 DBREF 3WHE 0 1 220 PDB 3WHE 3WHE 1 220 SEQRES 1 A 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 A 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 A 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 A 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 A 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 A 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 A 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 A 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 A 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 A 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 A 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 A 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 A 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 A 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 A 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 A 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 A 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 A 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 A 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 A 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 A 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 A 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 A 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 A 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 A 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 A 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 A 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 A 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 A 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 A 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 A 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 A 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 A 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 A 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 A 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 A 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 A 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 A 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 B 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 B 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 B 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 B 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 B 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 B 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 B 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 B 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 B 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 B 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 B 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 B 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 B 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 B 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 B 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 B 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 B 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 B 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 B 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 B 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 B 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 B 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 B 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 B 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 B 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 B 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 B 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 B 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 B 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 B 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 B 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 B 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 B 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 B 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 B 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 B 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 B 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 B 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 C 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 C 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 C 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 C 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 C 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 C 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 C 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 C 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 C 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 C 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 C 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 C 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 C 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 C 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 C 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 C 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 C 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 C 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 C 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 C 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 C 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 C 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 C 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 C 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 C 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 C 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 C 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 C 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 C 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 C 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 C 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 C 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 C 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 C 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 C 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 C 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 C 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 C 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 D 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 D 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 D 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 D 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 D 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 D 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 D 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 D 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 D 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 D 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 D 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 D 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 D 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 D 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 D 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 D 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 D 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 D 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 D 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 D 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 D 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 D 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 D 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 D 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 D 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 D 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 D 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 D 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 D 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 D 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 D 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 D 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 D 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 D 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 D 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 D 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 D 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 D 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 E 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 E 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 E 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 E 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 E 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 E 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 E 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 E 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 E 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 E 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 E 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 E 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 E 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 E 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 E 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 E 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 E 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 E 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 E 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 E 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 E 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 E 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 E 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 E 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 E 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 E 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 E 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 E 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 E 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 E 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 E 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 E 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 E 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 E 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 E 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 E 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 E 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 E 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 F 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 F 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 F 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 F 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 F 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 F 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 F 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 F 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 F 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 F 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 F 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 F 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 F 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 F 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 F 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 F 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 F 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 F 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 F 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 F 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 F 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 F 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 F 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 F 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 F 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 F 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 F 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 F 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 F 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 F 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 F 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 F 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 F 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 F 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 F 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 F 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 F 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 F 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 G 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 G 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 G 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 G 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 G 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 G 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 G 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 G 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 G 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 G 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 G 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 G 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 G 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 G 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 G 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 G 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 G 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 G 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 G 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 G 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 G 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 G 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 G 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 G 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 G 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 G 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 G 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 G 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 G 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 G 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 G 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 G 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 G 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 G 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 G 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 G 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 G 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 G 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 H 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 H 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 H 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 H 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 H 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 H 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 H 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 H 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 H 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 H 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 H 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 H 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 H 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 H 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 H 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 H 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 H 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 H 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 H 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 H 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 H 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 H 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 H 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 H 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 H 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 H 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 H 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 H 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 H 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 H 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 H 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 H 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 H 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 H 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 H 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 H 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 H 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 H 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 I 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 I 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 I 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 I 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 I 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 I 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 I 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 I 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 I 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 I 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 I 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 I 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 I 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 I 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 I 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 I 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 I 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 I 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 I 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 I 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 I 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 I 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 I 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 I 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 I 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 I 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 I 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 I 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 I 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 I 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 I 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 I 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 I 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 I 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 I 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 I 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 I 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 I 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 J 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 J 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 J 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 J 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 J 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 J 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 J 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 J 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 J 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 J 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 J 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 J 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 J 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 J 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 J 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 J 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 J 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 J 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 J 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 J 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 J 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 J 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 J 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 J 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 J 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 J 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 J 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 J 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 J 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 J 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 J 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 J 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 J 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 J 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 J 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 J 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 J 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 J 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 K 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 K 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 K 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 K 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 K 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 K 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 K 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 K 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 K 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 K 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 K 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 K 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 K 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 K 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 K 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 K 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 K 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 K 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 K 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 K 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 K 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 K 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 K 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 K 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 K 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 K 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 K 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 K 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 K 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 K 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 K 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 K 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 K 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 K 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 K 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 K 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 K 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 K 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 L 493 SER THR ALA THR LEU CYS LEU GLY HIS HIS ALA VAL PRO SEQRES 2 L 493 ASN GLY THR LEU VAL LYS THR ILE THR ASP ASP GLN ILE SEQRES 3 L 493 GLU VAL THR ASN ALA THR GLU LEU VAL GLN SER SER SER SEQRES 4 L 493 THR GLY LYS ILE CYS ASN ASN PRO HIS ARG ILE LEU ASP SEQRES 5 L 493 GLY ILE ASP CYS THR LEU ILE ASP ALA LEU LEU GLY ASP SEQRES 6 L 493 PRO HIS CYS ASP VAL PHE GLN ASN GLU THR TRP ASP LEU SEQRES 7 L 493 PHE VAL GLU ARG SER LYS ALA PHE SER ASN CYS TYR PRO SEQRES 8 L 493 TYR ASP VAL PRO ASP TYR ALA SER LEU ARG SER LEU VAL SEQRES 9 L 493 ALA SER SER GLY THR LEU GLU PHE ILE THR GLU GLY PHE SEQRES 10 L 493 THR TRP THR GLY VAL THR GLN ASN GLY GLY SER ASN ALA SEQRES 11 L 493 CYS LYS ARG GLY PRO GLY SER GLY PHE PHE SER ARG LEU SEQRES 12 L 493 ASN TRP VAL THR LYS SER GLY SER THR TYR PRO VAL LEU SEQRES 13 L 493 ASN VAL THR MET PRO ASN ASN ASP ASN PHE ASP LYS LEU SEQRES 14 L 493 TYR ILE TRP GLY VAL HIS HIS PRO SER THR ASN GLN GLU SEQRES 15 L 493 GLN THR SER LEU TYR VAL GLN ALA SER GLY ARG VAL THR SEQRES 16 L 493 VAL SER THR ARG ARG SER GLN GLN THR ILE ILE PRO ASN SEQRES 17 L 493 ILE GLY SER ARG PRO TRP VAL ARG GLY LEU SER SER ARG SEQRES 18 L 493 ILE SER ILE TYR TRP THR ILE VAL LYS PRO GLY ASP VAL SEQRES 19 L 493 LEU VAL ILE ASN SER ASN GLY ASN LEU ILE ALA PRO ARG SEQRES 20 L 493 GLY TYR PHE LYS MET ARG THR GLY LYS SER SER ILE MET SEQRES 21 L 493 ARG SER ASP ALA PRO ILE ASP THR CYS ILE SER GLU CYS SEQRES 22 L 493 ILE THR PRO ASN GLY SER ILE PRO ASN ASP LYS PRO PHE SEQRES 23 L 493 GLN ASN VAL ASN LYS ILE THR TYR GLY ALA CYS PRO LYS SEQRES 24 L 493 TYR VAL LYS GLN ASN THR LEU LYS LEU ALA THR GLY MET SEQRES 25 L 493 ARG ASN VAL PRO GLU LYS GLN THR ARG GLY LEU PHE GLY SEQRES 26 L 493 ALA ILE ALA GLY PHE ILE GLU ASN GLY TRP GLU GLY MET SEQRES 27 L 493 ILE ASP GLY TRP TYR GLY PHE ARG HIS GLN ASN SER GLU SEQRES 28 L 493 GLY THR GLY GLN ALA ALA ASP LEU LYS SER THR GLN ALA SEQRES 29 L 493 ALA ILE ASP GLN ILE ASN GLY LYS LEU ASN ARG VAL ILE SEQRES 30 L 493 GLU LYS THR ASN GLU LYS PHE HIS GLN ILE GLU LYS GLU SEQRES 31 L 493 PHE SER GLU VAL GLU GLY ARG ILE GLN ASP LEU GLU LYS SEQRES 32 L 493 TYR VAL GLU ASP THR LYS ILE ASP LEU TRP SER TYR ASN SEQRES 33 L 493 ALA GLU LEU LEU VAL ALA LEU GLU ASN GLN HIS THR ILE SEQRES 34 L 493 ASP LEU THR ASP SER GLU MET ASN LYS LEU PHE GLU LYS SEQRES 35 L 493 THR ARG ARG GLN LEU ARG GLU ASN ALA GLU ASP MET GLY SEQRES 36 L 493 ASN GLY CYS PHE LYS ILE TYR HIS LYS CYS ASP ASN ALA SEQRES 37 L 493 CYS ILE GLU SER ILE ARG ASN GLY THR TYR ASP HIS ASP SEQRES 38 L 493 VAL TYR ARG ASP GLU ALA LEU ASN ASN ARG PHE GLN SEQRES 1 M 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 M 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 M 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 M 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 M 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 M 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 M 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 M 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 M 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 M 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 M 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 M 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 M 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 M 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 M 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 M 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 M 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 M 226 LYS LYS VAL GLU PRO SEQRES 1 O 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 O 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 O 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 O 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 O 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 O 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 O 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 O 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 O 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 O 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 O 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 O 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 O 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 O 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 O 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 O 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 O 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 O 226 LYS LYS VAL GLU PRO SEQRES 1 Q 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 Q 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 Q 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 Q 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 Q 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 Q 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 Q 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 Q 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 Q 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 Q 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 Q 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 Q 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 Q 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 Q 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 Q 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 Q 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 Q 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 Q 226 LYS LYS VAL GLU PRO SEQRES 1 S 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 S 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 S 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 S 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 S 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 S 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 S 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 S 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 S 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 S 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 S 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 S 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 S 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 S 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 S 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 S 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 S 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 S 226 LYS LYS VAL GLU PRO SEQRES 1 U 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 U 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 U 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 U 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 U 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 U 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 U 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 U 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 U 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 U 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 U 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 U 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 U 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 U 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 U 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 U 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 U 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 U 226 LYS LYS VAL GLU PRO SEQRES 1 W 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 W 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 W 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 W 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 W 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 W 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 W 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 W 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 W 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 W 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 W 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 W 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 W 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 W 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 W 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 W 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 W 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 W 226 LYS LYS VAL GLU PRO SEQRES 1 Y 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 Y 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 Y 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 Y 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 Y 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 Y 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 Y 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 Y 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 Y 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 Y 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 Y 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 Y 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 Y 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 Y 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 Y 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 Y 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 Y 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 Y 226 LYS LYS VAL GLU PRO SEQRES 1 1 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 1 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 1 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 1 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 1 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 1 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 1 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 1 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 1 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 1 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 1 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 1 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 1 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 1 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 1 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 1 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 1 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 1 226 LYS LYS VAL GLU PRO SEQRES 1 3 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 3 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 3 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 3 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 3 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 3 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 3 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 3 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 3 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 3 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 3 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 3 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 3 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 3 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 3 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 3 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 3 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 3 226 LYS LYS VAL GLU PRO SEQRES 1 5 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 5 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 5 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 5 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 5 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 5 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 5 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 5 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 5 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 5 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 5 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 5 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 5 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 5 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 5 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 5 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 5 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 5 226 LYS LYS VAL GLU PRO SEQRES 1 7 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 7 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 7 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 7 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 7 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 7 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 7 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 7 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 7 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 7 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 7 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 7 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 7 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 7 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 7 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 7 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 7 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 7 226 LYS LYS VAL GLU PRO SEQRES 1 9 226 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 9 226 PRO GLY ALA SER VAL THR VAL SER CYS GLN VAL SER GLY SEQRES 3 9 226 TYR THR LEU THR SER TYR GLY LEU SER TRP VAL ARG GLN SEQRES 4 9 226 ALA PRO GLY GLN GLY LEU GLU TRP VAL GLY TRP ILE ASN SEQRES 5 9 226 THR TYR ASP GLY GLN THR LYS TYR VAL LYS LYS PHE GLN SEQRES 6 9 226 GLY ARG VAL THR MET THR THR HIS THR GLY THR ASN THR SEQRES 7 9 226 ALA TYR MET GLU MET LYS SER LEU ARG SER ASP ASP THR SEQRES 8 9 226 ALA VAL TYR TYR CYS ALA ARG VAL GLU GLY VAL ARG GLY SEQRES 9 9 226 VAL MET GLY PHE HIS TYR TYR PRO MET ASP VAL TRP GLY SEQRES 10 9 226 GLN GLY THR MET VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 9 226 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 9 226 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 9 226 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 9 226 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 9 226 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 9 226 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 9 226 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 9 226 LYS LYS VAL GLU PRO SEQRES 1 N 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 N 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 N 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 N 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 N 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 N 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 N 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 N 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 N 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 N 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 N 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 N 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 N 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 N 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 N 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 N 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 N 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 P 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 P 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 P 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 P 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 P 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 P 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 P 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 P 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 P 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 P 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 P 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 P 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 P 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 P 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 P 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 P 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 P 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 R 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 R 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 R 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 R 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 R 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 R 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 R 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 R 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 R 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 R 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 R 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 R 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 R 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 R 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 R 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 R 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 R 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 T 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 T 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 T 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 T 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 T 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 T 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 T 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 T 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 T 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 T 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 T 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 T 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 T 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 T 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 T 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 T 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 T 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 V 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 V 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 V 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 V 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 V 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 V 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 V 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 V 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 V 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 V 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 V 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 V 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 V 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 V 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 V 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 V 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 V 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 X 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 X 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 X 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 X 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 X 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 X 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 X 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 X 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 X 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 X 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 X 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 X 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 X 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 X 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 X 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 X 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 X 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 Z 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 Z 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 Z 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 Z 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 Z 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 Z 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 Z 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 Z 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 Z 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 Z 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 Z 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 Z 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 Z 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 Z 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 Z 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 Z 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 Z 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 2 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 2 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 2 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 2 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 2 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 2 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 2 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 2 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 2 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 2 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 2 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 2 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 2 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 2 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 2 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 2 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 2 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 4 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 4 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 4 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 4 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 4 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 4 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 4 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 4 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 4 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 4 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 4 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 4 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 4 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 4 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 4 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 4 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 4 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 6 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 6 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 6 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 6 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 6 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 6 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 6 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 6 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 6 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 6 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 6 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 6 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 6 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 6 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 6 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 6 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 6 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 8 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 8 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 8 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 8 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 8 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 8 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 8 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 8 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 8 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 8 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 8 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 8 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 8 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 8 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 8 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 8 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 8 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN SEQRES 1 0 220 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 0 220 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER SER SEQRES 3 0 220 SER ASN ILE GLY ALA GLY TYR ALA VAL HIS TRP TYR GLN SEQRES 4 0 220 GLN LEU PRO GLY THR ALA PRO LYS LEU LEU ILE SER GLY SEQRES 5 0 220 ASN SER ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER SEQRES 6 0 220 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE THR SEQRES 7 0 220 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 0 220 SER TYR ASP SER SER LEU SER GLY SER VAL PHE GLY GLY SEQRES 9 0 220 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 0 220 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 0 220 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 0 220 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 0 220 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 0 220 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 0 220 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 0 220 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 0 220 LYS THR VAL ALA PRO THR GLU CYS SER ALA ARG GLN MODRES 3WHE ASN H 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN H 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN B 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN L 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN F 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN J 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN I 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN G 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN D 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN J 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN A 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN H 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN K 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN E 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN G 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN E 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN B 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN C 285 ASN GLYCOSYLATION SITE MODRES 3WHE ASN K 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN F 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN H 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN L 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN C 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN A 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN I 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN L 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN D 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN F 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN G 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN D 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN E 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN A 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN C 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN K 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN B 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN J 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN C 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN I 38 ASN GLYCOSYLATION SITE MODRES 3WHE ASN I 81 ASN GLYCOSYLATION SITE MODRES 3WHE ASN K 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN G 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN F 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN B 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN J 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN L 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN E 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN D 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN A 483 ASN GLYCOSYLATION SITE MODRES 3WHE ASN H 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN J 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN L 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN F 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN G 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN B 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN C 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN K 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN I 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN D 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN E 165 ASN GLYCOSYLATION SITE MODRES 3WHE ASN A 165 ASN GLYCOSYLATION SITE HET NAG A 601 14 HET NAG A 602 14 HET BMA A 603 11 HET MAN A 604 11 HET MAN A 605 11 HET MAN A 606 11 HET MAN A 607 11 HET NAG A 608 14 HET NAG A 609 14 HET NAG A 610 14 HET BMA A 611 11 HET MAN A 612 11 HET MAN A 613 11 HET MAN A 614 11 HET NAG A 615 14 HET NAG A 616 14 HET BMA A 617 11 HET NAG A 618 14 HET NAG B 601 14 HET NAG B 602 14 HET BMA B 603 11 HET MAN B 604 11 HET MAN B 605 11 HET MAN B 606 11 HET MAN B 607 11 HET NAG B 608 14 HET NAG B 609 14 HET NAG B 610 14 HET BMA B 611 11 HET MAN B 612 11 HET MAN B 613 11 HET MAN B 614 11 HET NAG B 615 14 HET NAG B 616 14 HET BMA B 617 11 HET NAG B 618 14 HET NAG C 601 14 HET NAG C 602 14 HET BMA C 603 11 HET MAN C 604 11 HET MAN C 605 11 HET MAN C 606 11 HET MAN C 607 11 HET NAG C 608 14 HET NAG C 609 14 HET NAG C 610 14 HET BMA C 611 11 HET MAN C 612 11 HET MAN C 613 11 HET MAN C 614 11 HET NAG C 615 14 HET NAG C 616 14 HET BMA C 617 11 HET NAG C 618 14 HET NAG D 601 14 HET NAG D 602 14 HET BMA D 603 11 HET MAN D 604 11 HET MAN D 605 11 HET MAN D 606 11 HET MAN D 607 11 HET NAG D 608 14 HET NAG D 609 14 HET NAG D 610 14 HET BMA D 611 11 HET MAN D 612 11 HET MAN D 613 11 HET MAN D 614 11 HET NAG D 615 14 HET NAG D 616 14 HET BMA D 617 11 HET NAG D 618 14 HET NAG E 601 14 HET NAG E 602 14 HET BMA E 603 11 HET MAN E 604 11 HET MAN E 605 11 HET MAN E 606 11 HET MAN E 607 11 HET NAG E 608 14 HET NAG E 609 14 HET NAG E 610 14 HET BMA E 611 11 HET MAN E 612 11 HET MAN E 613 11 HET MAN E 614 11 HET NAG E 615 14 HET NAG E 616 14 HET BMA E 617 11 HET NAG E 618 14 HET NAG F 601 14 HET NAG F 602 14 HET BMA F 603 11 HET MAN F 604 11 HET MAN F 605 11 HET MAN F 606 11 HET MAN F 607 11 HET NAG F 608 14 HET NAG F 609 14 HET NAG F 610 14 HET BMA F 611 11 HET MAN F 612 11 HET MAN F 613 11 HET MAN F 614 11 HET NAG F 615 14 HET NAG F 616 14 HET BMA F 617 11 HET NAG F 618 14 HET NAG G 601 14 HET NAG G 602 14 HET BMA G 603 11 HET MAN G 604 11 HET MAN G 605 11 HET MAN G 606 11 HET MAN G 607 11 HET NAG G 608 14 HET NAG G 609 14 HET NAG G 610 14 HET BMA G 611 11 HET MAN G 612 11 HET MAN G 613 11 HET MAN G 614 11 HET NAG G 615 14 HET NAG G 616 14 HET BMA G 617 11 HET NAG G 618 14 HET NAG H 601 14 HET NAG H 602 14 HET BMA H 603 11 HET MAN H 604 11 HET MAN H 605 11 HET MAN H 606 11 HET MAN H 607 11 HET NAG H 608 14 HET NAG H 609 14 HET NAG H 610 14 HET BMA H 611 11 HET MAN H 612 11 HET MAN H 613 11 HET MAN H 614 11 HET NAG H 615 14 HET NAG H 616 14 HET BMA H 617 11 HET NAG H 618 14 HET NAG I 601 14 HET NAG I 602 14 HET BMA I 603 11 HET MAN I 604 11 HET MAN I 605 11 HET MAN I 606 11 HET MAN I 607 11 HET NAG I 608 14 HET NAG I 609 14 HET NAG I 610 14 HET BMA I 611 11 HET MAN I 612 11 HET MAN I 613 11 HET MAN I 614 11 HET NAG I 615 14 HET NAG I 616 14 HET BMA I 617 11 HET NAG I 618 14 HET NAG J 601 14 HET NAG J 602 14 HET BMA J 603 11 HET MAN J 604 11 HET MAN J 605 11 HET MAN J 606 11 HET MAN J 607 11 HET NAG J 608 14 HET NAG J 609 14 HET NAG J 610 14 HET BMA J 611 11 HET MAN J 612 11 HET MAN J 613 11 HET MAN J 614 11 HET NAG J 615 14 HET NAG J 616 14 HET BMA J 617 11 HET NAG J 618 14 HET NAG K 601 14 HET NAG K 602 14 HET BMA K 603 11 HET MAN K 604 11 HET MAN K 605 11 HET MAN K 606 11 HET MAN K 607 11 HET NAG K 608 14 HET NAG K 609 14 HET NAG K 610 14 HET BMA K 611 11 HET MAN K 612 11 HET MAN K 613 11 HET MAN K 614 11 HET NAG K 615 14 HET NAG K 616 14 HET BMA K 617 11 HET NAG K 618 14 HET NAG L 601 14 HET NAG L 602 14 HET BMA L 603 11 HET MAN L 604 11 HET MAN L 605 11 HET MAN L 606 11 HET MAN L 607 11 HET NAG L 608 14 HET NAG L 609 14 HET NAG L 610 14 HET BMA L 611 11 HET MAN L 612 11 HET MAN L 613 11 HET MAN L 614 11 HET NAG L 615 14 HET NAG L 616 14 HET BMA L 617 11 HET NAG L 618 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 37 NAG 96(C8 H15 N O6) FORMUL 37 BMA 36(C6 H12 O6) FORMUL 37 MAN 84(C6 H12 O6) HELIX 1 1 THR A 65 GLY A 72 1 8 HELIX 2 2 ASP A 73 GLN A 80 5 8 HELIX 3 3 ASP A 104 GLY A 116 1 13 HELIX 4 4 THR A 187 VAL A 196 1 10 HELIX 5 5 ASP A 366 ILE A 385 1 20 HELIX 6 6 GLY A 404 ARG A 456 1 53 HELIX 7 7 ASP A 474 GLY A 484 1 11 HELIX 8 8 ASP A 487 GLN A 501 1 15 HELIX 9 9 THR B 65 GLY B 72 1 8 HELIX 10 10 ASP B 73 GLN B 80 5 8 HELIX 11 11 ASP B 104 GLY B 116 1 13 HELIX 12 12 THR B 187 VAL B 196 1 10 HELIX 13 13 ASP B 366 ILE B 385 1 20 HELIX 14 14 GLY B 404 ARG B 456 1 53 HELIX 15 15 ASP B 474 GLY B 484 1 11 HELIX 16 16 ASP B 487 GLN B 501 1 15 HELIX 17 17 THR C 65 GLY C 72 1 8 HELIX 18 18 ASP C 73 GLN C 80 5 8 HELIX 19 19 ASP C 104 GLY C 116 1 13 HELIX 20 20 THR C 187 VAL C 196 1 10 HELIX 21 21 ASP C 366 ILE C 385 1 20 HELIX 22 22 GLY C 404 ARG C 456 1 53 HELIX 23 23 ASP C 474 GLY C 484 1 11 HELIX 24 24 ASP C 487 GLN C 501 1 15 HELIX 25 25 THR D 65 GLY D 72 1 8 HELIX 26 26 ASP D 73 GLN D 80 5 8 HELIX 27 27 ASP D 104 GLY D 116 1 13 HELIX 28 28 THR D 187 VAL D 196 1 10 HELIX 29 29 ASP D 366 ILE D 385 1 20 HELIX 30 30 GLY D 404 ARG D 456 1 53 HELIX 31 31 ASP D 474 GLY D 484 1 11 HELIX 32 32 ASP D 487 GLN D 501 1 15 HELIX 33 33 THR E 65 GLY E 72 1 8 HELIX 34 34 ASP E 73 GLN E 80 5 8 HELIX 35 35 ASP E 104 GLY E 116 1 13 HELIX 36 36 THR E 187 VAL E 196 1 10 HELIX 37 37 ASP E 366 ILE E 385 1 20 HELIX 38 38 GLY E 404 ARG E 456 1 53 HELIX 39 39 ASP E 474 GLY E 484 1 11 HELIX 40 40 ASP E 487 GLN E 501 1 15 HELIX 41 41 THR F 65 GLY F 72 1 8 HELIX 42 42 ASP F 73 GLN F 80 5 8 HELIX 43 43 ASP F 104 GLY F 116 1 13 HELIX 44 44 THR F 187 VAL F 196 1 10 HELIX 45 45 ASP F 366 ILE F 385 1 20 HELIX 46 46 GLY F 404 ARG F 456 1 53 HELIX 47 47 ASP F 474 GLY F 484 1 11 HELIX 48 48 ASP F 487 GLN F 501 1 15 HELIX 49 49 THR G 65 GLY G 72 1 8 HELIX 50 50 ASP G 73 GLN G 80 5 8 HELIX 51 51 ASP G 104 GLY G 116 1 13 HELIX 52 52 THR G 187 VAL G 196 1 10 HELIX 53 53 ASP G 366 ILE G 385 1 20 HELIX 54 54 GLY G 404 ARG G 456 1 53 HELIX 55 55 ASP G 474 GLY G 484 1 11 HELIX 56 56 ASP G 487 GLN G 501 1 15 HELIX 57 57 THR H 65 GLY H 72 1 8 HELIX 58 58 ASP H 73 GLN H 80 5 8 HELIX 59 59 ASP H 104 GLY H 116 1 13 HELIX 60 60 THR H 187 VAL H 196 1 10 HELIX 61 61 ASP H 366 ILE H 385 1 20 HELIX 62 62 GLY H 404 ARG H 456 1 53 HELIX 63 63 ASP H 474 GLY H 484 1 11 HELIX 64 64 ASP H 487 GLN H 501 1 15 HELIX 65 65 THR I 65 GLY I 72 1 8 HELIX 66 66 ASP I 73 GLN I 80 5 8 HELIX 67 67 ASP I 104 GLY I 116 1 13 HELIX 68 68 THR I 187 VAL I 196 1 10 HELIX 69 69 ASP I 366 ILE I 385 1 20 HELIX 70 70 GLY I 404 ARG I 456 1 53 HELIX 71 71 ASP I 474 GLY I 484 1 11 HELIX 72 72 ASP I 487 GLN I 501 1 15 HELIX 73 73 THR J 65 GLY J 72 1 8 HELIX 74 74 ASP J 73 GLN J 80 5 8 HELIX 75 75 ASP J 104 GLY J 116 1 13 HELIX 76 76 THR J 187 VAL J 196 1 10 HELIX 77 77 ASP J 366 ILE J 385 1 20 HELIX 78 78 GLY J 404 ARG J 456 1 53 HELIX 79 79 ASP J 474 GLY J 484 1 11 HELIX 80 80 ASP J 487 GLN J 501 1 15 HELIX 81 81 THR K 65 GLY K 72 1 8 HELIX 82 82 ASP K 73 GLN K 80 5 8 HELIX 83 83 ASP K 104 GLY K 116 1 13 HELIX 84 84 THR K 187 VAL K 196 1 10 HELIX 85 85 ASP K 366 ILE K 385 1 20 HELIX 86 86 GLY K 404 ARG K 456 1 53 HELIX 87 87 ASP K 474 GLY K 484 1 11 HELIX 88 88 ASP K 487 GLN K 501 1 15 HELIX 89 89 THR L 65 GLY L 72 1 8 HELIX 90 90 ASP L 73 GLN L 80 5 8 HELIX 91 91 ASP L 104 GLY L 116 1 13 HELIX 92 92 THR L 187 VAL L 196 1 10 HELIX 93 93 ASP L 366 ILE L 385 1 20 HELIX 94 94 GLY L 404 ARG L 456 1 53 HELIX 95 95 ASP L 474 GLY L 484 1 11 HELIX 96 96 ASP L 487 GLN L 501 1 15 HELIX 97 97 THR M 28 SER M 31 5 4 HELIX 98 98 VAL M 102 MET M 106 5 5 HELIX 99 99 SER M 166 ALA M 171 5 6 HELIX 100 100 PRO M 198 LEU M 202 5 5 HELIX 101 101 THR O 28 SER O 31 5 4 HELIX 102 102 VAL O 102 MET O 106 5 5 HELIX 103 103 SER O 166 ALA O 171 5 6 HELIX 104 104 PRO O 198 LEU O 202 5 5 HELIX 105 105 THR Q 28 SER Q 31 5 4 HELIX 106 106 VAL Q 102 MET Q 106 5 5 HELIX 107 107 SER Q 166 ALA Q 171 5 6 HELIX 108 108 PRO Q 198 LEU Q 202 5 5 HELIX 109 109 THR S 28 SER S 31 5 4 HELIX 110 110 VAL S 102 MET S 106 5 5 HELIX 111 111 SER S 166 ALA S 171 5 6 HELIX 112 112 PRO S 198 LEU S 202 5 5 HELIX 113 113 THR U 28 SER U 31 5 4 HELIX 114 114 VAL U 102 MET U 106 5 5 HELIX 115 115 SER U 166 ALA U 171 5 6 HELIX 116 116 PRO U 198 LEU U 202 5 5 HELIX 117 117 THR W 28 SER W 31 5 4 HELIX 118 118 VAL W 102 MET W 106 5 5 HELIX 119 119 SER W 166 ALA W 171 5 6 HELIX 120 120 PRO W 198 LEU W 202 5 5 HELIX 121 121 THR Y 28 SER Y 31 5 4 HELIX 122 122 VAL Y 102 MET Y 106 5 5 HELIX 123 123 SER Y 166 ALA Y 171 5 6 HELIX 124 124 PRO Y 198 LEU Y 202 5 5 HELIX 125 125 THR 1 28 SER 1 31 5 4 HELIX 126 126 VAL 1 102 MET 1 106 5 5 HELIX 127 127 SER 1 166 ALA 1 171 5 6 HELIX 128 128 PRO 1 198 LEU 1 202 5 5 HELIX 129 129 THR 3 28 SER 3 31 5 4 HELIX 130 130 VAL 3 102 MET 3 106 5 5 HELIX 131 131 SER 3 166 ALA 3 171 5 6 HELIX 132 132 PRO 3 198 LEU 3 202 5 5 HELIX 133 133 THR 5 28 SER 5 31 5 4 HELIX 134 134 VAL 5 102 MET 5 106 5 5 HELIX 135 135 SER 5 166 ALA 5 171 5 6 HELIX 136 136 PRO 5 198 LEU 5 202 5 5 HELIX 137 137 THR 7 28 SER 7 31 5 4 HELIX 138 138 VAL 7 102 MET 7 106 5 5 HELIX 139 139 SER 7 166 ALA 7 171 5 6 HELIX 140 140 PRO 7 198 LEU 7 202 5 5 HELIX 141 141 THR 9 28 SER 9 31 5 4 HELIX 142 142 VAL 9 102 MET 9 106 5 5 HELIX 143 143 SER 9 166 ALA 9 171 5 6 HELIX 144 144 PRO 9 198 LEU 9 202 5 5 HELIX 145 145 SER N 25 GLY N 30 1 6 HELIX 146 146 GLU N 129 ASN N 133 5 5 HELIX 147 147 THR N 186 HIS N 193 1 8 HELIX 148 148 SER P 25 GLY P 30 1 6 HELIX 149 149 GLU P 129 ASN P 133 5 5 HELIX 150 150 THR P 186 HIS P 193 1 8 HELIX 151 151 SER R 25 GLY R 30 1 6 HELIX 152 152 GLU R 129 ASN R 133 5 5 HELIX 153 153 THR R 186 HIS R 193 1 8 HELIX 154 154 SER T 25 GLY T 30 1 6 HELIX 155 155 GLU T 129 ASN T 133 5 5 HELIX 156 156 THR T 186 HIS T 193 1 8 HELIX 157 157 SER V 25 GLY V 30 1 6 HELIX 158 158 GLU V 129 ASN V 133 5 5 HELIX 159 159 THR V 186 HIS V 193 1 8 HELIX 160 160 SER X 25 GLY X 30 1 6 HELIX 161 161 GLU X 129 ASN X 133 5 5 HELIX 162 162 THR X 186 HIS X 193 1 8 HELIX 163 163 SER Z 25 GLY Z 30 1 6 HELIX 164 164 GLU Z 129 ASN Z 133 5 5 HELIX 165 165 THR Z 186 HIS Z 193 1 8 HELIX 166 166 SER 2 25 GLY 2 30 1 6 HELIX 167 167 GLU 2 129 ASN 2 133 5 5 HELIX 168 168 THR 2 186 HIS 2 193 1 8 HELIX 169 169 SER 4 25 GLY 4 30 1 6 HELIX 170 170 GLU 4 129 ASN 4 133 5 5 HELIX 171 171 THR 4 186 HIS 4 193 1 8 HELIX 172 172 SER 6 25 GLY 6 30 1 6 HELIX 173 173 GLU 6 129 ASN 6 133 5 5 HELIX 174 174 THR 6 186 HIS 6 193 1 8 HELIX 175 175 SER 8 25 GLY 8 30 1 6 HELIX 176 176 GLU 8 129 ASN 8 133 5 5 HELIX 177 177 THR 8 186 HIS 8 193 1 8 HELIX 178 178 SER 0 25 GLY 0 30 1 6 HELIX 179 179 GLU 0 129 ASN 0 133 5 5 HELIX 180 180 THR 0 186 HIS 0 193 1 8 SHEET 1 A 4 GLY A 360 ALA A 365 0 SHEET 2 A 4 TYR A 351 ASN A 357 -1 N PHE A 353 O ALA A 364 SHEET 3 A 4 ALA A 11 HIS A 17 -1 N CYS A 14 O ARG A 354 SHEET 4 A 4 CYS A 466 ILE A 469 -1 O PHE A 467 N LEU A 13 SHEET 1 B 2 THR A 24 VAL A 26 0 SHEET 2 B 2 ILE A 34 VAL A 36 -1 O VAL A 36 N THR A 24 SHEET 1 C 3 VAL A 43 GLN A 44 0 SHEET 2 C 3 PHE A 294 GLN A 295 1 O PHE A 294 N GLN A 44 SHEET 3 C 3 LYS A 307 TYR A 308 1 O LYS A 307 N GLN A 295 SHEET 1 D 3 ILE A 58 ASP A 60 0 SHEET 2 D 3 LEU A 86 GLU A 89 1 O VAL A 88 N LEU A 59 SHEET 3 D 3 SER A 266 ARG A 269 1 O MET A 268 N GLU A 89 SHEET 1 E 5 TYR A 100 ASP A 101 0 SHEET 2 E 5 ARG A 229 VAL A 237 1 O ILE A 230 N ASP A 101 SHEET 3 E 5 LYS A 176 HIS A 184 -1 N LYS A 176 O VAL A 237 SHEET 4 E 5 GLY A 256 LYS A 259 -1 O PHE A 258 N LEU A 177 SHEET 5 E 5 PHE A 120 THR A 122 -1 N ILE A 121 O TYR A 257 SHEET 1 F 4 TYR A 100 ASP A 101 0 SHEET 2 F 4 ARG A 229 VAL A 237 1 O ILE A 230 N ASP A 101 SHEET 3 F 4 LYS A 176 HIS A 184 -1 N LYS A 176 O VAL A 237 SHEET 4 F 4 LEU A 251 ILE A 252 -1 O ILE A 252 N GLY A 181 SHEET 1 G 2 VAL A 130 THR A 131 0 SHEET 2 G 2 THR A 155 LYS A 156 -1 O THR A 155 N THR A 131 SHEET 1 H 2 SER A 136 LYS A 140 0 SHEET 2 H 2 SER A 145 GLY A 146 -1 O GLY A 146 N SER A 136 SHEET 1 I 4 LEU A 164 PRO A 169 0 SHEET 2 I 4 VAL A 242 SER A 247 -1 O LEU A 243 N MET A 168 SHEET 3 I 4 VAL A 202 THR A 206 -1 N SER A 205 O VAL A 244 SHEET 4 I 4 GLN A 210 ILE A 213 -1 O GLN A 211 N VAL A 204 SHEET 1 J 2 GLY A 303 ALA A 304 0 SHEET 2 J 2 GLU A 390 LYS A 391 -1 O LYS A 391 N GLY A 303 SHEET 1 K 4 GLY B 360 ALA B 365 0 SHEET 2 K 4 TYR B 351 ASN B 357 -1 N PHE B 353 O ALA B 364 SHEET 3 K 4 ALA B 11 HIS B 17 -1 N CYS B 14 O ARG B 354 SHEET 4 K 4 CYS B 466 ILE B 469 -1 O PHE B 467 N LEU B 13 SHEET 1 L 2 THR B 24 VAL B 26 0 SHEET 2 L 2 ILE B 34 VAL B 36 -1 O VAL B 36 N THR B 24 SHEET 1 M 3 VAL B 43 GLN B 44 0 SHEET 2 M 3 PHE B 294 GLN B 295 1 O PHE B 294 N GLN B 44 SHEET 3 M 3 LYS B 307 TYR B 308 1 O LYS B 307 N GLN B 295 SHEET 1 N 3 ILE B 58 ASP B 60 0 SHEET 2 N 3 LEU B 86 GLU B 89 1 O VAL B 88 N LEU B 59 SHEET 3 N 3 SER B 266 ARG B 269 1 O MET B 268 N GLU B 89 SHEET 1 O 5 TYR B 100 ASP B 101 0 SHEET 2 O 5 ARG B 229 VAL B 237 1 O ILE B 230 N ASP B 101 SHEET 3 O 5 LYS B 176 HIS B 184 -1 N LYS B 176 O VAL B 237 SHEET 4 O 5 GLY B 256 LYS B 259 -1 O PHE B 258 N LEU B 177 SHEET 5 O 5 PHE B 120 THR B 122 -1 N ILE B 121 O TYR B 257 SHEET 1 P 4 TYR B 100 ASP B 101 0 SHEET 2 P 4 ARG B 229 VAL B 237 1 O ILE B 230 N ASP B 101 SHEET 3 P 4 LYS B 176 HIS B 184 -1 N LYS B 176 O VAL B 237 SHEET 4 P 4 LEU B 251 ILE B 252 -1 O ILE B 252 N GLY B 181 SHEET 1 Q 2 VAL B 130 THR B 131 0 SHEET 2 Q 2 THR B 155 LYS B 156 -1 O THR B 155 N THR B 131 SHEET 1 R 2 SER B 136 LYS B 140 0 SHEET 2 R 2 SER B 145 GLY B 146 -1 O GLY B 146 N SER B 136 SHEET 1 S 4 LEU B 164 PRO B 169 0 SHEET 2 S 4 VAL B 242 SER B 247 -1 O LEU B 243 N MET B 168 SHEET 3 S 4 VAL B 202 THR B 206 -1 N SER B 205 O VAL B 244 SHEET 4 S 4 GLN B 210 ILE B 213 -1 O GLN B 211 N VAL B 204 SHEET 1 T 2 GLY B 303 ALA B 304 0 SHEET 2 T 2 GLU B 390 LYS B 391 -1 O LYS B 391 N GLY B 303 SHEET 1 U 4 GLY C 360 ALA C 365 0 SHEET 2 U 4 TYR C 351 ASN C 357 -1 N PHE C 353 O ALA C 364 SHEET 3 U 4 ALA C 11 HIS C 17 -1 N THR C 12 O GLN C 356 SHEET 4 U 4 CYS C 466 ILE C 469 -1 O PHE C 467 N LEU C 13 SHEET 1 V 2 THR C 24 VAL C 26 0 SHEET 2 V 2 ILE C 34 VAL C 36 -1 O VAL C 36 N THR C 24 SHEET 1 W 3 VAL C 43 GLN C 44 0 SHEET 2 W 3 PHE C 294 GLN C 295 1 O PHE C 294 N GLN C 44 SHEET 3 W 3 LYS C 307 TYR C 308 1 O LYS C 307 N GLN C 295 SHEET 1 X 3 ILE C 58 ASP C 60 0 SHEET 2 X 3 LEU C 86 GLU C 89 1 O VAL C 88 N LEU C 59 SHEET 3 X 3 SER C 266 ARG C 269 1 O MET C 268 N GLU C 89 SHEET 1 Y 5 TYR C 100 ASP C 101 0 SHEET 2 Y 5 ARG C 229 VAL C 237 1 O ILE C 230 N ASP C 101 SHEET 3 Y 5 LYS C 176 HIS C 184 -1 N LYS C 176 O VAL C 237 SHEET 4 Y 5 GLY C 256 LYS C 259 -1 O PHE C 258 N LEU C 177 SHEET 5 Y 5 PHE C 120 THR C 122 -1 N ILE C 121 O TYR C 257 SHEET 1 Z 4 TYR C 100 ASP C 101 0 SHEET 2 Z 4 ARG C 229 VAL C 237 1 O ILE C 230 N ASP C 101 SHEET 3 Z 4 LYS C 176 HIS C 184 -1 N LYS C 176 O VAL C 237 SHEET 4 Z 4 LEU C 251 ILE C 252 -1 O ILE C 252 N GLY C 181 SHEET 1 AA 2 SER C 136 LYS C 140 0 SHEET 2 AA 2 SER C 145 GLY C 146 -1 O GLY C 146 N SER C 136 SHEET 1 AB 4 LEU C 164 PRO C 169 0 SHEET 2 AB 4 VAL C 242 SER C 247 -1 O LEU C 243 N MET C 168 SHEET 3 AB 4 VAL C 202 THR C 206 -1 N SER C 205 O VAL C 244 SHEET 4 AB 4 GLN C 210 ILE C 213 -1 O GLN C 211 N VAL C 204 SHEET 1 AC 2 GLY C 303 ALA C 304 0 SHEET 2 AC 2 GLU C 390 LYS C 391 -1 O LYS C 391 N GLY C 303 SHEET 1 AD 4 GLY D 360 ALA D 365 0 SHEET 2 AD 4 TYR D 351 ASN D 357 -1 N PHE D 353 O ALA D 364 SHEET 3 AD 4 ALA D 11 HIS D 17 -1 N CYS D 14 O ARG D 354 SHEET 4 AD 4 CYS D 466 ILE D 469 -1 O PHE D 467 N LEU D 13 SHEET 1 AE 2 THR D 24 VAL D 26 0 SHEET 2 AE 2 ILE D 34 VAL D 36 -1 O VAL D 36 N THR D 24 SHEET 1 AF 3 VAL D 43 GLN D 44 0 SHEET 2 AF 3 PHE D 294 GLN D 295 1 O PHE D 294 N GLN D 44 SHEET 3 AF 3 LYS D 307 TYR D 308 1 O LYS D 307 N GLN D 295 SHEET 1 AG 3 ILE D 58 ASP D 60 0 SHEET 2 AG 3 LEU D 86 GLU D 89 1 O VAL D 88 N LEU D 59 SHEET 3 AG 3 SER D 266 ARG D 269 1 O MET D 268 N GLU D 89 SHEET 1 AH 5 TYR D 100 ASP D 101 0 SHEET 2 AH 5 ARG D 229 VAL D 237 1 O ILE D 230 N ASP D 101 SHEET 3 AH 5 LYS D 176 HIS D 184 -1 N LYS D 176 O VAL D 237 SHEET 4 AH 5 GLY D 256 LYS D 259 -1 O PHE D 258 N LEU D 177 SHEET 5 AH 5 PHE D 120 THR D 122 -1 N ILE D 121 O TYR D 257 SHEET 1 AI 4 TYR D 100 ASP D 101 0 SHEET 2 AI 4 ARG D 229 VAL D 237 1 O ILE D 230 N ASP D 101 SHEET 3 AI 4 LYS D 176 HIS D 184 -1 N LYS D 176 O VAL D 237 SHEET 4 AI 4 LEU D 251 ILE D 252 -1 O ILE D 252 N GLY D 181 SHEET 1 AJ 2 VAL D 130 THR D 131 0 SHEET 2 AJ 2 THR D 155 LYS D 156 -1 O THR D 155 N THR D 131 SHEET 1 AK 2 SER D 136 LYS D 140 0 SHEET 2 AK 2 SER D 145 GLY D 146 -1 O GLY D 146 N SER D 136 SHEET 1 AL 4 LEU D 164 PRO D 169 0 SHEET 2 AL 4 VAL D 242 SER D 247 -1 O LEU D 243 N MET D 168 SHEET 3 AL 4 VAL D 202 THR D 206 -1 N SER D 205 O VAL D 244 SHEET 4 AL 4 GLN D 210 ILE D 213 -1 O GLN D 211 N VAL D 204 SHEET 1 AM 2 GLY D 303 ALA D 304 0 SHEET 2 AM 2 GLU D 390 LYS D 391 -1 O LYS D 391 N GLY D 303 SHEET 1 AN 4 GLY E 360 ALA E 365 0 SHEET 2 AN 4 TYR E 351 ASN E 357 -1 N PHE E 353 O ALA E 364 SHEET 3 AN 4 ALA E 11 HIS E 17 -1 N CYS E 14 O ARG E 354 SHEET 4 AN 4 CYS E 466 ILE E 469 -1 O PHE E 467 N LEU E 13 SHEET 1 AO 2 THR E 24 VAL E 26 0 SHEET 2 AO 2 ILE E 34 VAL E 36 -1 O VAL E 36 N THR E 24 SHEET 1 AP 3 VAL E 43 GLN E 44 0 SHEET 2 AP 3 PHE E 294 GLN E 295 1 O PHE E 294 N GLN E 44 SHEET 3 AP 3 LYS E 307 TYR E 308 1 O LYS E 307 N GLN E 295 SHEET 1 AQ 3 ILE E 58 ASP E 60 0 SHEET 2 AQ 3 LEU E 86 GLU E 89 1 O VAL E 88 N LEU E 59 SHEET 3 AQ 3 SER E 266 ARG E 269 1 O MET E 268 N GLU E 89 SHEET 1 AR 5 TYR E 100 ASP E 101 0 SHEET 2 AR 5 ARG E 229 VAL E 237 1 O ILE E 230 N ASP E 101 SHEET 3 AR 5 LYS E 176 HIS E 184 -1 N LYS E 176 O VAL E 237 SHEET 4 AR 5 GLY E 256 LYS E 259 -1 O PHE E 258 N LEU E 177 SHEET 5 AR 5 PHE E 120 THR E 122 -1 N ILE E 121 O TYR E 257 SHEET 1 AS 4 TYR E 100 ASP E 101 0 SHEET 2 AS 4 ARG E 229 VAL E 237 1 O ILE E 230 N ASP E 101 SHEET 3 AS 4 LYS E 176 HIS E 184 -1 N LYS E 176 O VAL E 237 SHEET 4 AS 4 LEU E 251 ILE E 252 -1 O ILE E 252 N GLY E 181 SHEET 1 AT 2 VAL E 130 THR E 131 0 SHEET 2 AT 2 THR E 155 LYS E 156 -1 O THR E 155 N THR E 131 SHEET 1 AU 2 SER E 136 LYS E 140 0 SHEET 2 AU 2 SER E 145 GLY E 146 -1 O GLY E 146 N SER E 136 SHEET 1 AV 4 LEU E 164 PRO E 169 0 SHEET 2 AV 4 VAL E 242 SER E 247 -1 O LEU E 243 N MET E 168 SHEET 3 AV 4 VAL E 202 THR E 206 -1 N SER E 205 O VAL E 244 SHEET 4 AV 4 GLN E 210 ILE E 213 -1 O GLN E 211 N VAL E 204 SHEET 1 AW 2 GLY E 303 ALA E 304 0 SHEET 2 AW 2 GLU E 390 LYS E 391 -1 O LYS E 391 N GLY E 303 SHEET 1 AX 4 GLY F 360 ALA F 365 0 SHEET 2 AX 4 TYR F 351 ASN F 357 -1 N PHE F 353 O ALA F 364 SHEET 3 AX 4 ALA F 11 HIS F 17 -1 N CYS F 14 O ARG F 354 SHEET 4 AX 4 CYS F 466 ILE F 469 -1 O PHE F 467 N LEU F 13 SHEET 1 AY 2 THR F 24 VAL F 26 0 SHEET 2 AY 2 ILE F 34 VAL F 36 -1 O VAL F 36 N THR F 24 SHEET 1 AZ 3 VAL F 43 GLN F 44 0 SHEET 2 AZ 3 PHE F 294 GLN F 295 1 O PHE F 294 N GLN F 44 SHEET 3 AZ 3 LYS F 307 TYR F 308 1 O LYS F 307 N GLN F 295 SHEET 1 BA 3 ILE F 58 ASP F 60 0 SHEET 2 BA 3 LEU F 86 GLU F 89 1 O VAL F 88 N LEU F 59 SHEET 3 BA 3 SER F 266 ARG F 269 1 O MET F 268 N GLU F 89 SHEET 1 BB 5 TYR F 100 ASP F 101 0 SHEET 2 BB 5 ARG F 229 VAL F 237 1 O ILE F 230 N ASP F 101 SHEET 3 BB 5 LYS F 176 HIS F 184 -1 N LYS F 176 O VAL F 237 SHEET 4 BB 5 GLY F 256 LYS F 259 -1 O PHE F 258 N LEU F 177 SHEET 5 BB 5 PHE F 120 THR F 122 -1 N ILE F 121 O TYR F 257 SHEET 1 BC 4 TYR F 100 ASP F 101 0 SHEET 2 BC 4 ARG F 229 VAL F 237 1 O ILE F 230 N ASP F 101 SHEET 3 BC 4 LYS F 176 HIS F 184 -1 N LYS F 176 O VAL F 237 SHEET 4 BC 4 LEU F 251 ILE F 252 -1 O ILE F 252 N GLY F 181 SHEET 1 BD 2 VAL F 130 THR F 131 0 SHEET 2 BD 2 THR F 155 LYS F 156 -1 O THR F 155 N THR F 131 SHEET 1 BE 2 SER F 136 LYS F 140 0 SHEET 2 BE 2 SER F 145 GLY F 146 -1 O GLY F 146 N SER F 136 SHEET 1 BF 4 LEU F 164 PRO F 169 0 SHEET 2 BF 4 VAL F 242 SER F 247 -1 O LEU F 243 N MET F 168 SHEET 3 BF 4 VAL F 202 THR F 206 -1 N SER F 205 O VAL F 244 SHEET 4 BF 4 GLN F 210 ILE F 213 -1 O GLN F 211 N VAL F 204 SHEET 1 BG 2 GLY F 303 ALA F 304 0 SHEET 2 BG 2 GLU F 390 LYS F 391 -1 O LYS F 391 N GLY F 303 SHEET 1 BH 4 GLY G 360 ALA G 365 0 SHEET 2 BH 4 TYR G 351 ASN G 357 -1 N PHE G 353 O ALA G 364 SHEET 3 BH 4 ALA G 11 HIS G 17 -1 N CYS G 14 O ARG G 354 SHEET 4 BH 4 CYS G 466 ILE G 469 -1 O PHE G 467 N LEU G 13 SHEET 1 BI 2 THR G 24 VAL G 26 0 SHEET 2 BI 2 ILE G 34 VAL G 36 -1 O VAL G 36 N THR G 24 SHEET 1 BJ 3 VAL G 43 GLN G 44 0 SHEET 2 BJ 3 PHE G 294 GLN G 295 1 O PHE G 294 N GLN G 44 SHEET 3 BJ 3 LYS G 307 TYR G 308 1 O LYS G 307 N GLN G 295 SHEET 1 BK 3 ILE G 58 ASP G 60 0 SHEET 2 BK 3 LEU G 86 GLU G 89 1 O VAL G 88 N LEU G 59 SHEET 3 BK 3 SER G 266 ARG G 269 1 O MET G 268 N GLU G 89 SHEET 1 BL 5 TYR G 100 ASP G 101 0 SHEET 2 BL 5 ARG G 229 VAL G 237 1 O ILE G 230 N ASP G 101 SHEET 3 BL 5 LYS G 176 HIS G 184 -1 N LYS G 176 O VAL G 237 SHEET 4 BL 5 GLY G 256 LYS G 259 -1 O PHE G 258 N LEU G 177 SHEET 5 BL 5 PHE G 120 THR G 122 -1 N ILE G 121 O TYR G 257 SHEET 1 BM 4 TYR G 100 ASP G 101 0 SHEET 2 BM 4 ARG G 229 VAL G 237 1 O ILE G 230 N ASP G 101 SHEET 3 BM 4 LYS G 176 HIS G 184 -1 N LYS G 176 O VAL G 237 SHEET 4 BM 4 LEU G 251 ILE G 252 -1 O ILE G 252 N GLY G 181 SHEET 1 BN 2 VAL G 130 THR G 131 0 SHEET 2 BN 2 THR G 155 LYS G 156 -1 O THR G 155 N THR G 131 SHEET 1 BO 2 SER G 136 LYS G 140 0 SHEET 2 BO 2 SER G 145 GLY G 146 -1 O GLY G 146 N SER G 136 SHEET 1 BP 4 LEU G 164 PRO G 169 0 SHEET 2 BP 4 VAL G 242 SER G 247 -1 O LEU G 243 N MET G 168 SHEET 3 BP 4 VAL G 202 THR G 206 -1 N SER G 205 O VAL G 244 SHEET 4 BP 4 GLN G 210 ILE G 213 -1 O GLN G 211 N VAL G 204 SHEET 1 BQ 2 GLY G 303 ALA G 304 0 SHEET 2 BQ 2 GLU G 390 LYS G 391 -1 O LYS G 391 N GLY G 303 SHEET 1 BR 4 GLY H 360 ALA H 365 0 SHEET 2 BR 4 TYR H 351 ASN H 357 -1 N PHE H 353 O ALA H 364 SHEET 3 BR 4 ALA H 11 HIS H 17 -1 N CYS H 14 O ARG H 354 SHEET 4 BR 4 CYS H 466 ILE H 469 -1 O PHE H 467 N LEU H 13 SHEET 1 BS 2 THR H 24 VAL H 26 0 SHEET 2 BS 2 ILE H 34 VAL H 36 -1 O VAL H 36 N THR H 24 SHEET 1 BT 3 VAL H 43 GLN H 44 0 SHEET 2 BT 3 PHE H 294 GLN H 295 1 O PHE H 294 N GLN H 44 SHEET 3 BT 3 LYS H 307 TYR H 308 1 O LYS H 307 N GLN H 295 SHEET 1 BU 3 ILE H 58 ASP H 60 0 SHEET 2 BU 3 LEU H 86 GLU H 89 1 O VAL H 88 N LEU H 59 SHEET 3 BU 3 SER H 266 ARG H 269 1 O MET H 268 N GLU H 89 SHEET 1 BV 5 TYR H 100 ASP H 101 0 SHEET 2 BV 5 ARG H 229 VAL H 237 1 O ILE H 230 N ASP H 101 SHEET 3 BV 5 LYS H 176 HIS H 184 -1 N LYS H 176 O VAL H 237 SHEET 4 BV 5 GLY H 256 LYS H 259 -1 O PHE H 258 N LEU H 177 SHEET 5 BV 5 PHE H 120 THR H 122 -1 N ILE H 121 O TYR H 257 SHEET 1 BW 4 TYR H 100 ASP H 101 0 SHEET 2 BW 4 ARG H 229 VAL H 237 1 O ILE H 230 N ASP H 101 SHEET 3 BW 4 LYS H 176 HIS H 184 -1 N LYS H 176 O VAL H 237 SHEET 4 BW 4 LEU H 251 ILE H 252 -1 O ILE H 252 N GLY H 181 SHEET 1 BX 2 VAL H 130 THR H 131 0 SHEET 2 BX 2 THR H 155 LYS H 156 -1 O THR H 155 N THR H 131 SHEET 1 BY 2 SER H 136 LYS H 140 0 SHEET 2 BY 2 SER H 145 GLY H 146 -1 O GLY H 146 N SER H 136 SHEET 1 BZ 4 LEU H 164 PRO H 169 0 SHEET 2 BZ 4 VAL H 242 SER H 247 -1 O LEU H 243 N MET H 168 SHEET 3 BZ 4 VAL H 202 THR H 206 -1 N SER H 205 O VAL H 244 SHEET 4 BZ 4 GLN H 210 ILE H 213 -1 O GLN H 211 N VAL H 204 SHEET 1 CA 2 GLY H 303 ALA H 304 0 SHEET 2 CA 2 GLU H 390 LYS H 391 -1 O LYS H 391 N GLY H 303 SHEET 1 CB 4 GLY I 360 ALA I 365 0 SHEET 2 CB 4 TYR I 351 ASN I 357 -1 N PHE I 353 O ALA I 364 SHEET 3 CB 4 ALA I 11 HIS I 17 -1 N CYS I 14 O ARG I 354 SHEET 4 CB 4 CYS I 466 ILE I 469 -1 O PHE I 467 N LEU I 13 SHEET 1 CC 2 THR I 24 VAL I 26 0 SHEET 2 CC 2 ILE I 34 VAL I 36 -1 O VAL I 36 N THR I 24 SHEET 1 CD 3 VAL I 43 GLN I 44 0 SHEET 2 CD 3 PHE I 294 GLN I 295 1 O PHE I 294 N GLN I 44 SHEET 3 CD 3 LYS I 307 TYR I 308 1 O LYS I 307 N GLN I 295 SHEET 1 CE 3 ILE I 58 ASP I 60 0 SHEET 2 CE 3 LEU I 86 GLU I 89 1 O VAL I 88 N LEU I 59 SHEET 3 CE 3 SER I 266 ARG I 269 1 O MET I 268 N GLU I 89 SHEET 1 CF 5 TYR I 100 ASP I 101 0 SHEET 2 CF 5 ARG I 229 VAL I 237 1 O ILE I 232 N ASP I 101 SHEET 3 CF 5 LYS I 176 HIS I 184 -1 N LYS I 176 O VAL I 237 SHEET 4 CF 5 GLY I 256 LYS I 259 -1 O PHE I 258 N LEU I 177 SHEET 5 CF 5 PHE I 120 THR I 122 -1 N ILE I 121 O TYR I 257 SHEET 1 CG 4 TYR I 100 ASP I 101 0 SHEET 2 CG 4 ARG I 229 VAL I 237 1 O ILE I 232 N ASP I 101 SHEET 3 CG 4 LYS I 176 HIS I 184 -1 N LYS I 176 O VAL I 237 SHEET 4 CG 4 LEU I 251 ILE I 252 -1 O ILE I 252 N GLY I 181 SHEET 1 CH 2 VAL I 130 THR I 131 0 SHEET 2 CH 2 THR I 155 LYS I 156 -1 O THR I 155 N THR I 131 SHEET 1 CI 2 SER I 136 LYS I 140 0 SHEET 2 CI 2 SER I 145 GLY I 146 -1 O GLY I 146 N SER I 136 SHEET 1 CJ 4 LEU I 164 PRO I 169 0 SHEET 2 CJ 4 VAL I 242 SER I 247 -1 O LEU I 243 N MET I 168 SHEET 3 CJ 4 VAL I 202 THR I 206 -1 N SER I 205 O VAL I 244 SHEET 4 CJ 4 GLN I 210 ILE I 213 -1 O GLN I 211 N VAL I 204 SHEET 1 CK 2 GLY I 303 ALA I 304 0 SHEET 2 CK 2 GLU I 390 LYS I 391 -1 O LYS I 391 N GLY I 303 SHEET 1 CL 4 GLY J 360 ALA J 365 0 SHEET 2 CL 4 TYR J 351 ASN J 357 -1 N PHE J 353 O ALA J 364 SHEET 3 CL 4 ALA J 11 HIS J 17 -1 N CYS J 14 O ARG J 354 SHEET 4 CL 4 CYS J 466 ILE J 469 -1 O PHE J 467 N LEU J 13 SHEET 1 CM 2 THR J 24 VAL J 26 0 SHEET 2 CM 2 ILE J 34 VAL J 36 -1 O VAL J 36 N THR J 24 SHEET 1 CN 3 VAL J 43 GLN J 44 0 SHEET 2 CN 3 PHE J 294 GLN J 295 1 O PHE J 294 N GLN J 44 SHEET 3 CN 3 LYS J 307 TYR J 308 1 O LYS J 307 N GLN J 295 SHEET 1 CO 3 ILE J 58 ASP J 60 0 SHEET 2 CO 3 LEU J 86 GLU J 89 1 O VAL J 88 N LEU J 59 SHEET 3 CO 3 SER J 266 ARG J 269 1 O MET J 268 N GLU J 89 SHEET 1 CP 5 TYR J 100 ASP J 101 0 SHEET 2 CP 5 ARG J 229 VAL J 237 1 O ILE J 230 N ASP J 101 SHEET 3 CP 5 LYS J 176 HIS J 184 -1 N LYS J 176 O VAL J 237 SHEET 4 CP 5 GLY J 256 LYS J 259 -1 O PHE J 258 N LEU J 177 SHEET 5 CP 5 PHE J 120 THR J 122 -1 N ILE J 121 O TYR J 257 SHEET 1 CQ 4 TYR J 100 ASP J 101 0 SHEET 2 CQ 4 ARG J 229 VAL J 237 1 O ILE J 230 N ASP J 101 SHEET 3 CQ 4 LYS J 176 HIS J 184 -1 N LYS J 176 O VAL J 237 SHEET 4 CQ 4 LEU J 251 ILE J 252 -1 O ILE J 252 N GLY J 181 SHEET 1 CR 2 VAL J 130 THR J 131 0 SHEET 2 CR 2 THR J 155 LYS J 156 -1 O THR J 155 N THR J 131 SHEET 1 CS 2 SER J 136 LYS J 140 0 SHEET 2 CS 2 SER J 145 GLY J 146 -1 O GLY J 146 N SER J 136 SHEET 1 CT 4 LEU J 164 PRO J 169 0 SHEET 2 CT 4 VAL J 242 SER J 247 -1 O LEU J 243 N MET J 168 SHEET 3 CT 4 VAL J 202 THR J 206 -1 N SER J 205 O VAL J 244 SHEET 4 CT 4 GLN J 210 ILE J 213 -1 O GLN J 211 N VAL J 204 SHEET 1 CU 2 GLY J 303 ALA J 304 0 SHEET 2 CU 2 GLU J 390 LYS J 391 -1 O LYS J 391 N GLY J 303 SHEET 1 CV 4 GLY K 360 ALA K 365 0 SHEET 2 CV 4 TYR K 351 ASN K 357 -1 N PHE K 353 O ALA K 364 SHEET 3 CV 4 ALA K 11 HIS K 17 -1 N CYS K 14 O ARG K 354 SHEET 4 CV 4 CYS K 466 ILE K 469 -1 O PHE K 467 N LEU K 13 SHEET 1 CW 2 THR K 24 VAL K 26 0 SHEET 2 CW 2 ILE K 34 VAL K 36 -1 O VAL K 36 N THR K 24 SHEET 1 CX 3 VAL K 43 GLN K 44 0 SHEET 2 CX 3 PHE K 294 GLN K 295 1 O PHE K 294 N GLN K 44 SHEET 3 CX 3 LYS K 307 TYR K 308 1 O LYS K 307 N GLN K 295 SHEET 1 CY 3 ILE K 58 ASP K 60 0 SHEET 2 CY 3 LEU K 86 GLU K 89 1 O VAL K 88 N LEU K 59 SHEET 3 CY 3 SER K 266 ARG K 269 1 O MET K 268 N GLU K 89 SHEET 1 CZ 5 TYR K 100 ASP K 101 0 SHEET 2 CZ 5 ARG K 229 VAL K 237 1 O ILE K 230 N ASP K 101 SHEET 3 CZ 5 LYS K 176 HIS K 184 -1 N LYS K 176 O VAL K 237 SHEET 4 CZ 5 GLY K 256 LYS K 259 -1 O PHE K 258 N LEU K 177 SHEET 5 CZ 5 PHE K 120 THR K 122 -1 N ILE K 121 O TYR K 257 SHEET 1 DA 4 TYR K 100 ASP K 101 0 SHEET 2 DA 4 ARG K 229 VAL K 237 1 O ILE K 230 N ASP K 101 SHEET 3 DA 4 LYS K 176 HIS K 184 -1 N LYS K 176 O VAL K 237 SHEET 4 DA 4 LEU K 251 ILE K 252 -1 O ILE K 252 N GLY K 181 SHEET 1 DB 2 VAL K 130 THR K 131 0 SHEET 2 DB 2 THR K 155 LYS K 156 -1 O THR K 155 N THR K 131 SHEET 1 DC 2 SER K 136 LYS K 140 0 SHEET 2 DC 2 SER K 145 GLY K 146 -1 O GLY K 146 N SER K 136 SHEET 1 DD 4 LEU K 164 PRO K 169 0 SHEET 2 DD 4 VAL K 242 SER K 247 -1 O LEU K 243 N MET K 168 SHEET 3 DD 4 VAL K 202 THR K 206 -1 N SER K 205 O VAL K 244 SHEET 4 DD 4 GLN K 210 ILE K 213 -1 O GLN K 211 N VAL K 204 SHEET 1 DE 2 GLY K 303 ALA K 304 0 SHEET 2 DE 2 GLU K 390 LYS K 391 -1 O LYS K 391 N GLY K 303 SHEET 1 DF 4 GLY L 360 ALA L 365 0 SHEET 2 DF 4 TYR L 351 ASN L 357 -1 N PHE L 353 O ALA L 364 SHEET 3 DF 4 ALA L 11 HIS L 17 -1 N CYS L 14 O ARG L 354 SHEET 4 DF 4 CYS L 466 ILE L 469 -1 O PHE L 467 N LEU L 13 SHEET 1 DG 2 THR L 24 VAL L 26 0 SHEET 2 DG 2 ILE L 34 VAL L 36 -1 O VAL L 36 N THR L 24 SHEET 1 DH 3 VAL L 43 GLN L 44 0 SHEET 2 DH 3 PHE L 294 GLN L 295 1 O PHE L 294 N GLN L 44 SHEET 3 DH 3 LYS L 307 TYR L 308 1 O LYS L 307 N GLN L 295 SHEET 1 DI 3 ILE L 58 ASP L 60 0 SHEET 2 DI 3 LEU L 86 GLU L 89 1 O VAL L 88 N LEU L 59 SHEET 3 DI 3 SER L 266 ARG L 269 1 O MET L 268 N GLU L 89 SHEET 1 DJ 5 TYR L 100 ASP L 101 0 SHEET 2 DJ 5 ARG L 229 VAL L 237 1 O ILE L 230 N ASP L 101 SHEET 3 DJ 5 LYS L 176 HIS L 184 -1 N LYS L 176 O VAL L 237 SHEET 4 DJ 5 GLY L 256 LYS L 259 -1 O PHE L 258 N LEU L 177 SHEET 5 DJ 5 PHE L 120 THR L 122 -1 N ILE L 121 O TYR L 257 SHEET 1 DK 4 TYR L 100 ASP L 101 0 SHEET 2 DK 4 ARG L 229 VAL L 237 1 O ILE L 230 N ASP L 101 SHEET 3 DK 4 LYS L 176 HIS L 184 -1 N LYS L 176 O VAL L 237 SHEET 4 DK 4 LEU L 251 ILE L 252 -1 O ILE L 252 N GLY L 181 SHEET 1 DL 2 VAL L 130 THR L 131 0 SHEET 2 DL 2 THR L 155 LYS L 156 -1 O THR L 155 N THR L 131 SHEET 1 DM 2 SER L 136 LYS L 140 0 SHEET 2 DM 2 SER L 145 GLY L 146 -1 O GLY L 146 N SER L 136 SHEET 1 DN 4 LEU L 164 PRO L 169 0 SHEET 2 DN 4 VAL L 242 SER L 247 -1 O LEU L 243 N MET L 168 SHEET 3 DN 4 VAL L 202 THR L 206 -1 N SER L 205 O VAL L 244 SHEET 4 DN 4 GLN L 210 ILE L 213 -1 O GLN L 211 N VAL L 204 SHEET 1 DO 2 GLY L 303 ALA L 304 0 SHEET 2 DO 2 GLU L 390 LYS L 391 -1 O LYS L 391 N GLY L 303 SHEET 1 DP 3 VAL M 18 GLN M 23 0 SHEET 2 DP 3 THR M 78 MET M 83 -1 O ALA M 79 N CYS M 22 SHEET 3 DP 3 VAL M 68 THR M 72 -1 N THR M 71 O TYR M 80 SHEET 1 DQ 5 THR M 58 TYR M 60 0 SHEET 2 DQ 5 GLU M 46 ASN M 52 -1 N TRP M 50 O LYS M 59 SHEET 3 DQ 5 GLY M 33 GLN M 39 -1 N TRP M 36 O VAL M 48 SHEET 4 DQ 5 VAL M 93 VAL M 99 -1 O VAL M 93 N GLN M 39 SHEET 5 DQ 5 ASP M 114 TRP M 116 -1 O ASP M 114 N ARG M 98 SHEET 1 DR 5 THR M 58 TYR M 60 0 SHEET 2 DR 5 GLU M 46 ASN M 52 -1 N TRP M 50 O LYS M 59 SHEET 3 DR 5 GLY M 33 GLN M 39 -1 N TRP M 36 O VAL M 48 SHEET 4 DR 5 VAL M 93 VAL M 99 -1 O VAL M 93 N GLN M 39 SHEET 5 DR 5 THR M 120 MET M 121 -1 O THR M 120 N TYR M 94 SHEET 1 DS 4 SER M 133 LEU M 137 0 SHEET 2 DS 4 ALA M 149 TYR M 158 -1 O GLY M 152 N LEU M 137 SHEET 3 DS 4 TYR M 189 VAL M 197 -1 O VAL M 197 N ALA M 149 SHEET 4 DS 4 HIS M 177 PHE M 179 -1 N PHE M 179 O SER M 192 SHEET 1 DT 2 TYR M 207 HIS M 213 0 SHEET 2 DT 2 THR M 218 VAL M 224 -1 O VAL M 220 N VAL M 211 SHEET 1 DU 6 GLU O 10 VAL O 11 0 SHEET 2 DU 6 THR O 120 THR O 123 1 O THR O 123 N GLU O 10 SHEET 3 DU 6 VAL O 93 VAL O 99 -1 N TYR O 94 O THR O 120 SHEET 4 DU 6 GLY O 33 GLN O 39 -1 N GLN O 39 O VAL O 93 SHEET 5 DU 6 GLU O 46 ASN O 52 -1 O VAL O 48 N TRP O 36 SHEET 6 DU 6 THR O 58 TYR O 60 -1 O LYS O 59 N TRP O 50 SHEET 1 DV 3 VAL O 18 GLN O 23 0 SHEET 2 DV 3 THR O 78 MET O 83 -1 O ALA O 79 N CYS O 22 SHEET 3 DV 3 VAL O 68 THR O 72 -1 N THR O 69 O GLU O 82 SHEET 1 DW 4 SER O 133 LEU O 137 0 SHEET 2 DW 4 ALA O 149 TYR O 158 -1 O GLY O 152 N LEU O 137 SHEET 3 DW 4 TYR O 189 VAL O 197 -1 O VAL O 197 N ALA O 149 SHEET 4 DW 4 HIS O 177 PHE O 179 -1 N PHE O 179 O SER O 192 SHEET 1 DX 2 TYR O 207 HIS O 213 0 SHEET 2 DX 2 THR O 218 VAL O 224 -1 O VAL O 220 N VAL O 211 SHEET 1 DY 3 VAL Q 18 GLN Q 23 0 SHEET 2 DY 3 THR Q 78 MET Q 83 -1 O ALA Q 79 N CYS Q 22 SHEET 3 DY 3 VAL Q 68 THR Q 72 -1 N THR Q 69 O GLU Q 82 SHEET 1 DZ 5 THR Q 58 TYR Q 60 0 SHEET 2 DZ 5 GLU Q 46 ASN Q 52 -1 N TRP Q 50 O LYS Q 59 SHEET 3 DZ 5 GLY Q 33 GLN Q 39 -1 N TRP Q 36 O VAL Q 48 SHEET 4 DZ 5 VAL Q 93 VAL Q 99 -1 O VAL Q 93 N GLN Q 39 SHEET 5 DZ 5 THR Q 120 MET Q 121 -1 O THR Q 120 N TYR Q 94 SHEET 1 EA 4 SER Q 133 LEU Q 137 0 SHEET 2 EA 4 ALA Q 149 TYR Q 158 -1 O GLY Q 152 N LEU Q 137 SHEET 3 EA 4 TYR Q 189 VAL Q 197 -1 O VAL Q 197 N ALA Q 149 SHEET 4 EA 4 HIS Q 177 PHE Q 179 -1 N PHE Q 179 O SER Q 192 SHEET 1 EB 2 TYR Q 207 HIS Q 213 0 SHEET 2 EB 2 THR Q 218 VAL Q 224 -1 O VAL Q 220 N VAL Q 211 SHEET 1 EC 3 VAL S 18 GLN S 23 0 SHEET 2 EC 3 THR S 78 MET S 83 -1 O ALA S 79 N CYS S 22 SHEET 3 EC 3 VAL S 68 THR S 72 -1 N THR S 69 O GLU S 82 SHEET 1 ED 5 THR S 58 TYR S 60 0 SHEET 2 ED 5 GLU S 46 ASN S 52 -1 N TRP S 50 O LYS S 59 SHEET 3 ED 5 GLY S 33 GLN S 39 -1 N TRP S 36 O VAL S 48 SHEET 4 ED 5 VAL S 93 VAL S 99 -1 O VAL S 93 N GLN S 39 SHEET 5 ED 5 THR S 120 MET S 121 -1 O THR S 120 N TYR S 94 SHEET 1 EE 4 SER S 133 LEU S 137 0 SHEET 2 EE 4 ALA S 149 TYR S 158 -1 O GLY S 152 N LEU S 137 SHEET 3 EE 4 TYR S 189 VAL S 197 -1 O VAL S 197 N ALA S 149 SHEET 4 EE 4 HIS S 177 PHE S 179 -1 N PHE S 179 O SER S 192 SHEET 1 EF 2 TYR S 207 HIS S 213 0 SHEET 2 EF 2 THR S 218 VAL S 224 -1 O VAL S 220 N VAL S 211 SHEET 1 EG 2 VAL U 11 LYS U 12 0 SHEET 2 EG 2 THR U 123 VAL U 124 1 O THR U 123 N LYS U 12 SHEET 1 EH 3 VAL U 18 GLN U 23 0 SHEET 2 EH 3 THR U 78 MET U 83 -1 O ALA U 79 N CYS U 22 SHEET 3 EH 3 VAL U 68 THR U 72 -1 N THR U 71 O TYR U 80 SHEET 1 EI 5 THR U 58 TYR U 60 0 SHEET 2 EI 5 GLU U 46 ASN U 52 -1 N TRP U 50 O LYS U 59 SHEET 3 EI 5 GLY U 33 GLN U 39 -1 N TRP U 36 O VAL U 48 SHEET 4 EI 5 VAL U 93 VAL U 99 -1 O VAL U 93 N GLN U 39 SHEET 5 EI 5 ASP U 114 TRP U 116 -1 O ASP U 114 N ARG U 98 SHEET 1 EJ 5 THR U 58 TYR U 60 0 SHEET 2 EJ 5 GLU U 46 ASN U 52 -1 N TRP U 50 O LYS U 59 SHEET 3 EJ 5 GLY U 33 GLN U 39 -1 N TRP U 36 O VAL U 48 SHEET 4 EJ 5 VAL U 93 VAL U 99 -1 O VAL U 93 N GLN U 39 SHEET 5 EJ 5 THR U 120 MET U 121 -1 O THR U 120 N TYR U 94 SHEET 1 EK 4 SER U 133 LEU U 137 0 SHEET 2 EK 4 ALA U 149 TYR U 158 -1 O GLY U 152 N LEU U 137 SHEET 3 EK 4 TYR U 189 VAL U 197 -1 O VAL U 197 N ALA U 149 SHEET 4 EK 4 HIS U 177 PHE U 179 -1 N PHE U 179 O SER U 192 SHEET 1 EL 2 TYR U 207 HIS U 213 0 SHEET 2 EL 2 THR U 218 VAL U 224 -1 O VAL U 220 N VAL U 211 SHEET 1 EM 3 VAL W 18 GLN W 23 0 SHEET 2 EM 3 THR W 78 MET W 83 -1 O ALA W 79 N CYS W 22 SHEET 3 EM 3 VAL W 68 THR W 72 -1 N THR W 71 O TYR W 80 SHEET 1 EN 5 THR W 58 TYR W 60 0 SHEET 2 EN 5 GLU W 46 ASN W 52 -1 N TRP W 50 O LYS W 59 SHEET 3 EN 5 GLY W 33 GLN W 39 -1 N TRP W 36 O VAL W 48 SHEET 4 EN 5 VAL W 93 VAL W 99 -1 O VAL W 93 N GLN W 39 SHEET 5 EN 5 THR W 120 MET W 121 -1 O THR W 120 N TYR W 94 SHEET 1 EO 4 SER W 133 LEU W 137 0 SHEET 2 EO 4 ALA W 149 TYR W 158 -1 O GLY W 152 N LEU W 137 SHEET 3 EO 4 TYR W 189 VAL W 197 -1 O VAL W 197 N ALA W 149 SHEET 4 EO 4 HIS W 177 PHE W 179 -1 N PHE W 179 O SER W 192 SHEET 1 EP 2 TYR W 207 HIS W 213 0 SHEET 2 EP 2 THR W 218 VAL W 224 -1 O VAL W 220 N VAL W 211 SHEET 1 EQ 3 VAL Y 18 GLN Y 23 0 SHEET 2 EQ 3 THR Y 78 MET Y 83 -1 O ALA Y 79 N CYS Y 22 SHEET 3 EQ 3 VAL Y 68 THR Y 72 -1 N THR Y 69 O GLU Y 82 SHEET 1 ER 5 THR Y 58 TYR Y 60 0 SHEET 2 ER 5 GLU Y 46 ASN Y 52 -1 N TRP Y 50 O LYS Y 59 SHEET 3 ER 5 GLY Y 33 GLN Y 39 -1 N TRP Y 36 O VAL Y 48 SHEET 4 ER 5 VAL Y 93 VAL Y 99 -1 O VAL Y 93 N GLN Y 39 SHEET 5 ER 5 ASP Y 114 TRP Y 116 -1 O ASP Y 114 N ARG Y 98 SHEET 1 ES 4 SER Y 133 LEU Y 137 0 SHEET 2 ES 4 ALA Y 149 TYR Y 158 -1 O GLY Y 152 N LEU Y 137 SHEET 3 ES 4 TYR Y 189 VAL Y 197 -1 O VAL Y 197 N ALA Y 149 SHEET 4 ES 4 HIS Y 177 PHE Y 179 -1 N PHE Y 179 O SER Y 192 SHEET 1 ET 2 TYR Y 207 HIS Y 213 0 SHEET 2 ET 2 THR Y 218 VAL Y 224 -1 O VAL Y 220 N VAL Y 211 SHEET 1 EU 3 VAL 1 18 GLN 1 23 0 SHEET 2 EU 3 THR 1 78 MET 1 83 -1 O ALA 1 79 N CYS 1 22 SHEET 3 EU 3 VAL 1 68 THR 1 72 -1 N THR 1 71 O TYR 1 80 SHEET 1 EV 5 THR 1 58 TYR 1 60 0 SHEET 2 EV 5 GLU 1 46 ASN 1 52 -1 N TRP 1 50 O LYS 1 59 SHEET 3 EV 5 GLY 1 33 GLN 1 39 -1 N TRP 1 36 O VAL 1 48 SHEET 4 EV 5 VAL 1 93 VAL 1 99 -1 O VAL 1 93 N GLN 1 39 SHEET 5 EV 5 ASP 1 114 TRP 1 116 -1 O ASP 1 114 N ARG 1 98 SHEET 1 EW 5 THR 1 58 TYR 1 60 0 SHEET 2 EW 5 GLU 1 46 ASN 1 52 -1 N TRP 1 50 O LYS 1 59 SHEET 3 EW 5 GLY 1 33 GLN 1 39 -1 N TRP 1 36 O VAL 1 48 SHEET 4 EW 5 VAL 1 93 VAL 1 99 -1 O VAL 1 93 N GLN 1 39 SHEET 5 EW 5 THR 1 120 MET 1 121 -1 O THR 1 120 N TYR 1 94 SHEET 1 EX 4 SER 1 133 LEU 1 137 0 SHEET 2 EX 4 ALA 1 149 TYR 1 158 -1 O GLY 1 152 N LEU 1 137 SHEET 3 EX 4 TYR 1 189 VAL 1 197 -1 O VAL 1 197 N ALA 1 149 SHEET 4 EX 4 HIS 1 177 PHE 1 179 -1 N PHE 1 179 O SER 1 192 SHEET 1 EY 2 TYR 1 207 HIS 1 213 0 SHEET 2 EY 2 THR 1 218 VAL 1 224 -1 O VAL 1 220 N VAL 1 211 SHEET 1 EZ 3 VAL 3 18 GLN 3 23 0 SHEET 2 EZ 3 THR 3 78 MET 3 83 -1 O ALA 3 79 N CYS 3 22 SHEET 3 EZ 3 VAL 3 68 THR 3 72 -1 N THR 3 71 O TYR 3 80 SHEET 1 FA 5 THR 3 58 TYR 3 60 0 SHEET 2 FA 5 GLU 3 46 ASN 3 52 -1 N TRP 3 50 O LYS 3 59 SHEET 3 FA 5 GLY 3 33 GLN 3 39 -1 N TRP 3 36 O VAL 3 48 SHEET 4 FA 5 VAL 3 93 VAL 3 99 -1 O VAL 3 93 N GLN 3 39 SHEET 5 FA 5 THR 3 120 MET 3 121 -1 O THR 3 120 N TYR 3 94 SHEET 1 FB 4 SER 3 133 LEU 3 137 0 SHEET 2 FB 4 ALA 3 149 TYR 3 158 -1 O GLY 3 152 N LEU 3 137 SHEET 3 FB 4 TYR 3 189 VAL 3 197 -1 O VAL 3 197 N ALA 3 149 SHEET 4 FB 4 HIS 3 177 PHE 3 179 -1 N PHE 3 179 O SER 3 192 SHEET 1 FC 2 TYR 3 207 HIS 3 213 0 SHEET 2 FC 2 THR 3 218 VAL 3 224 -1 O VAL 3 220 N VAL 3 211 SHEET 1 FD 2 VAL 5 11 LYS 5 12 0 SHEET 2 FD 2 THR 5 123 VAL 5 124 1 O THR 5 123 N LYS 5 12 SHEET 1 FE 3 VAL 5 18 GLN 5 23 0 SHEET 2 FE 3 THR 5 78 MET 5 83 -1 O ALA 5 79 N CYS 5 22 SHEET 3 FE 3 VAL 5 68 THR 5 72 -1 N THR 5 69 O GLU 5 82 SHEET 1 FF 5 THR 5 58 TYR 5 60 0 SHEET 2 FF 5 GLU 5 46 ASN 5 52 -1 N TRP 5 50 O LYS 5 59 SHEET 3 FF 5 GLY 5 33 GLN 5 39 -1 N TRP 5 36 O VAL 5 48 SHEET 4 FF 5 VAL 5 93 VAL 5 99 -1 O VAL 5 93 N GLN 5 39 SHEET 5 FF 5 THR 5 120 MET 5 121 -1 O THR 5 120 N TYR 5 94 SHEET 1 FG 4 SER 5 133 LEU 5 137 0 SHEET 2 FG 4 ALA 5 149 TYR 5 158 -1 O GLY 5 152 N LEU 5 137 SHEET 3 FG 4 TYR 5 189 VAL 5 197 -1 O VAL 5 197 N ALA 5 149 SHEET 4 FG 4 HIS 5 177 PHE 5 179 -1 N PHE 5 179 O SER 5 192 SHEET 1 FH 2 TYR 5 207 HIS 5 213 0 SHEET 2 FH 2 THR 5 218 VAL 5 224 -1 O VAL 5 220 N VAL 5 211 SHEET 1 FI 6 GLU 7 10 VAL 7 11 0 SHEET 2 FI 6 THR 7 120 THR 7 123 1 O MET 7 121 N GLU 7 10 SHEET 3 FI 6 VAL 7 93 VAL 7 99 -1 N TYR 7 94 O THR 7 120 SHEET 4 FI 6 GLY 7 33 GLN 7 39 -1 N GLN 7 39 O VAL 7 93 SHEET 5 FI 6 GLU 7 46 ASN 7 52 -1 O VAL 7 48 N TRP 7 36 SHEET 6 FI 6 THR 7 58 TYR 7 60 -1 O LYS 7 59 N TRP 7 50 SHEET 1 FJ 3 VAL 7 18 GLN 7 23 0 SHEET 2 FJ 3 THR 7 78 MET 7 83 -1 O ALA 7 79 N CYS 7 22 SHEET 3 FJ 3 VAL 7 68 THR 7 72 -1 N THR 7 71 O TYR 7 80 SHEET 1 FK 4 SER 7 133 LEU 7 137 0 SHEET 2 FK 4 ALA 7 149 TYR 7 158 -1 O GLY 7 152 N LEU 7 137 SHEET 3 FK 4 TYR 7 189 VAL 7 197 -1 O VAL 7 197 N ALA 7 149 SHEET 4 FK 4 HIS 7 177 PHE 7 179 -1 N PHE 7 179 O SER 7 192 SHEET 1 FL 2 TYR 7 207 HIS 7 213 0 SHEET 2 FL 2 THR 7 218 VAL 7 224 -1 O VAL 7 220 N VAL 7 211 SHEET 1 FM 3 VAL 9 18 GLN 9 23 0 SHEET 2 FM 3 THR 9 78 MET 9 83 -1 O ALA 9 79 N CYS 9 22 SHEET 3 FM 3 VAL 9 68 THR 9 72 -1 N THR 9 71 O TYR 9 80 SHEET 1 FN 5 THR 9 58 TYR 9 60 0 SHEET 2 FN 5 GLU 9 46 ASN 9 52 -1 N TRP 9 50 O LYS 9 59 SHEET 3 FN 5 GLY 9 33 GLN 9 39 -1 N TRP 9 36 O VAL 9 48 SHEET 4 FN 5 VAL 9 93 VAL 9 99 -1 O VAL 9 93 N GLN 9 39 SHEET 5 FN 5 THR 9 120 MET 9 121 -1 O THR 9 120 N TYR 9 94 SHEET 1 FO 4 SER 9 133 LEU 9 137 0 SHEET 2 FO 4 ALA 9 149 TYR 9 158 -1 O GLY 9 152 N LEU 9 137 SHEET 3 FO 4 TYR 9 189 VAL 9 197 -1 O VAL 9 197 N ALA 9 149 SHEET 4 FO 4 HIS 9 177 PHE 9 179 -1 N PHE 9 179 O SER 9 192 SHEET 1 FP 2 TYR 9 207 HIS 9 213 0 SHEET 2 FP 2 THR 9 218 VAL 9 224 -1 O VAL 9 220 N VAL 9 211 SHEET 1 FQ 5 VAL N 10 GLY N 12 0 SHEET 2 FQ 5 THR N 106 VAL N 110 1 O THR N 109 N VAL N 10 SHEET 3 FQ 5 ASP N 87 TYR N 93 -1 N TYR N 88 O THR N 106 SHEET 4 FQ 5 HIS N 36 GLN N 40 -1 N GLN N 40 O ASP N 87 SHEET 5 FQ 5 LEU N 48 ILE N 50 -1 O ILE N 50 N TRP N 37 SHEET 1 FR 4 VAL N 10 GLY N 12 0 SHEET 2 FR 4 THR N 106 VAL N 110 1 O THR N 109 N VAL N 10 SHEET 3 FR 4 ASP N 87 TYR N 93 -1 N TYR N 88 O THR N 106 SHEET 4 FR 4 SER N 100 VAL N 101 -1 O VAL N 101 N SER N 92 SHEET 1 FS 3 VAL N 18 THR N 23 0 SHEET 2 FS 3 SER N 72 ILE N 77 -1 O ALA N 73 N CYS N 22 SHEET 3 FS 3 PHE N 64 SER N 69 -1 N SER N 69 O SER N 72 SHEET 1 FT 4 SER N 119 PHE N 123 0 SHEET 2 FT 4 ALA N 135 PHE N 144 -1 O SER N 142 N SER N 119 SHEET 3 FT 4 TYR N 177 LEU N 185 -1 O ALA N 179 N ILE N 141 SHEET 4 FT 4 GLU N 165 LYS N 171 -1 N THR N 167 O SER N 180 SHEET 1 FU 3 THR N 150 LYS N 154 0 SHEET 2 FU 3 TYR N 196 HIS N 202 -1 O THR N 201 N THR N 150 SHEET 3 FU 3 SER N 205 VAL N 211 -1 O LYS N 209 N CYS N 198 SHEET 1 FV 5 VAL P 10 GLY P 12 0 SHEET 2 FV 5 THR P 106 VAL P 110 1 O THR P 109 N VAL P 10 SHEET 3 FV 5 ASP P 87 TYR P 93 -1 N TYR P 88 O THR P 106 SHEET 4 FV 5 HIS P 36 GLN P 40 -1 N GLN P 40 O ASP P 87 SHEET 5 FV 5 LEU P 48 ILE P 50 -1 O ILE P 50 N TRP P 37 SHEET 1 FW 4 VAL P 10 GLY P 12 0 SHEET 2 FW 4 THR P 106 VAL P 110 1 O THR P 109 N VAL P 10 SHEET 3 FW 4 ASP P 87 TYR P 93 -1 N TYR P 88 O THR P 106 SHEET 4 FW 4 SER P 100 VAL P 101 -1 O VAL P 101 N SER P 92 SHEET 1 FX 3 VAL P 18 THR P 23 0 SHEET 2 FX 3 SER P 72 ILE P 77 -1 O ALA P 73 N CYS P 22 SHEET 3 FX 3 PHE P 64 SER P 69 -1 N SER P 69 O SER P 72 SHEET 1 FY 4 SER P 119 PHE P 123 0 SHEET 2 FY 4 ALA P 135 PHE P 144 -1 O SER P 142 N SER P 119 SHEET 3 FY 4 TYR P 177 LEU P 185 -1 O ALA P 179 N ILE P 141 SHEET 4 FY 4 GLU P 165 LYS P 171 -1 N THR P 167 O SER P 180 SHEET 1 FZ 3 THR P 150 LYS P 154 0 SHEET 2 FZ 3 TYR P 196 HIS P 202 -1 O THR P 201 N THR P 150 SHEET 3 FZ 3 SER P 205 VAL P 211 -1 O SER P 205 N HIS P 202 SHEET 1 GA 5 VAL R 10 GLY R 12 0 SHEET 2 GA 5 THR R 106 VAL R 110 1 O THR R 109 N VAL R 10 SHEET 3 GA 5 ASP R 87 TYR R 93 -1 N TYR R 88 O THR R 106 SHEET 4 GA 5 HIS R 36 GLN R 40 -1 N HIS R 36 O GLN R 91 SHEET 5 GA 5 LEU R 48 ILE R 50 -1 O ILE R 50 N TRP R 37 SHEET 1 GB 4 VAL R 10 GLY R 12 0 SHEET 2 GB 4 THR R 106 VAL R 110 1 O THR R 109 N VAL R 10 SHEET 3 GB 4 ASP R 87 TYR R 93 -1 N TYR R 88 O THR R 106 SHEET 4 GB 4 SER R 100 VAL R 101 -1 O VAL R 101 N SER R 92 SHEET 1 GC 3 VAL R 18 THR R 23 0 SHEET 2 GC 3 SER R 72 ILE R 77 -1 O ALA R 73 N CYS R 22 SHEET 3 GC 3 PHE R 64 SER R 69 -1 N SER R 69 O SER R 72 SHEET 1 GD 4 SER R 119 PHE R 123 0 SHEET 2 GD 4 ALA R 135 PHE R 144 -1 O SER R 142 N SER R 119 SHEET 3 GD 4 TYR R 177 LEU R 185 -1 O LEU R 185 N ALA R 135 SHEET 4 GD 4 GLU R 165 LYS R 171 -1 N THR R 167 O SER R 180 SHEET 1 GE 3 THR R 150 LYS R 154 0 SHEET 2 GE 3 TYR R 196 HIS R 202 -1 O THR R 201 N THR R 150 SHEET 3 GE 3 SER R 205 VAL R 211 -1 O LYS R 209 N CYS R 198 SHEET 1 GF 5 VAL T 10 GLY T 12 0 SHEET 2 GF 5 THR T 106 VAL T 110 1 O THR T 109 N VAL T 10 SHEET 3 GF 5 ASP T 87 TYR T 93 -1 N TYR T 88 O THR T 106 SHEET 4 GF 5 HIS T 36 GLN T 40 -1 N GLN T 40 O ASP T 87 SHEET 5 GF 5 LEU T 48 ILE T 50 -1 O ILE T 50 N TRP T 37 SHEET 1 GG 4 VAL T 10 GLY T 12 0 SHEET 2 GG 4 THR T 106 VAL T 110 1 O THR T 109 N VAL T 10 SHEET 3 GG 4 ASP T 87 TYR T 93 -1 N TYR T 88 O THR T 106 SHEET 4 GG 4 SER T 100 VAL T 101 -1 O VAL T 101 N SER T 92 SHEET 1 GH 3 VAL T 18 THR T 23 0 SHEET 2 GH 3 SER T 72 ILE T 77 -1 O ALA T 73 N CYS T 22 SHEET 3 GH 3 PHE T 64 SER T 69 -1 N SER T 69 O SER T 72 SHEET 1 GI 4 SER T 119 PHE T 123 0 SHEET 2 GI 4 ALA T 135 PHE T 144 -1 O SER T 142 N SER T 119 SHEET 3 GI 4 TYR T 177 LEU T 185 -1 O ALA T 179 N ILE T 141 SHEET 4 GI 4 GLU T 165 LYS T 171 -1 N THR T 167 O SER T 180 SHEET 1 GJ 3 THR T 150 LYS T 154 0 SHEET 2 GJ 3 TYR T 196 HIS T 202 -1 O THR T 201 N THR T 150 SHEET 3 GJ 3 SER T 205 VAL T 211 -1 O LYS T 209 N CYS T 198 SHEET 1 GK 5 VAL V 10 GLY V 12 0 SHEET 2 GK 5 THR V 106 VAL V 110 1 O THR V 109 N VAL V 10 SHEET 3 GK 5 ASP V 87 TYR V 93 -1 N TYR V 88 O THR V 106 SHEET 4 GK 5 HIS V 36 GLN V 40 -1 N GLN V 40 O ASP V 87 SHEET 5 GK 5 LEU V 48 ILE V 50 -1 O ILE V 50 N TRP V 37 SHEET 1 GL 4 VAL V 10 GLY V 12 0 SHEET 2 GL 4 THR V 106 VAL V 110 1 O THR V 109 N VAL V 10 SHEET 3 GL 4 ASP V 87 TYR V 93 -1 N TYR V 88 O THR V 106 SHEET 4 GL 4 SER V 100 VAL V 101 -1 O VAL V 101 N SER V 92 SHEET 1 GM 3 VAL V 18 THR V 23 0 SHEET 2 GM 3 SER V 72 ILE V 77 -1 O ALA V 73 N CYS V 22 SHEET 3 GM 3 PHE V 64 SER V 69 -1 N SER V 69 O SER V 72 SHEET 1 GN 4 SER V 119 PHE V 123 0 SHEET 2 GN 4 ALA V 135 PHE V 144 -1 O SER V 142 N SER V 119 SHEET 3 GN 4 TYR V 177 LEU V 185 -1 O ALA V 179 N ILE V 141 SHEET 4 GN 4 GLU V 165 LYS V 171 -1 N THR V 167 O SER V 180 SHEET 1 GO 3 THR V 150 LYS V 154 0 SHEET 2 GO 3 TYR V 196 HIS V 202 -1 O THR V 201 N THR V 150 SHEET 3 GO 3 SER V 205 VAL V 211 -1 O SER V 205 N HIS V 202 SHEET 1 GP 5 VAL X 10 GLY X 12 0 SHEET 2 GP 5 THR X 106 VAL X 110 1 O THR X 109 N VAL X 10 SHEET 3 GP 5 ASP X 87 TYR X 93 -1 N TYR X 88 O THR X 106 SHEET 4 GP 5 HIS X 36 GLN X 40 -1 N GLN X 40 O ASP X 87 SHEET 5 GP 5 LEU X 48 ILE X 50 -1 O ILE X 50 N TRP X 37 SHEET 1 GQ 4 VAL X 10 GLY X 12 0 SHEET 2 GQ 4 THR X 106 VAL X 110 1 O THR X 109 N VAL X 10 SHEET 3 GQ 4 ASP X 87 TYR X 93 -1 N TYR X 88 O THR X 106 SHEET 4 GQ 4 SER X 100 VAL X 101 -1 O VAL X 101 N SER X 92 SHEET 1 GR 3 VAL X 18 THR X 23 0 SHEET 2 GR 3 SER X 72 ILE X 77 -1 O ALA X 73 N CYS X 22 SHEET 3 GR 3 PHE X 64 SER X 69 -1 N SER X 69 O SER X 72 SHEET 1 GS 4 SER X 119 PHE X 123 0 SHEET 2 GS 4 ALA X 135 PHE X 144 -1 O SER X 142 N SER X 119 SHEET 3 GS 4 TYR X 177 LEU X 185 -1 O LEU X 185 N ALA X 135 SHEET 4 GS 4 GLU X 165 LYS X 171 -1 N THR X 167 O SER X 180 SHEET 1 GT 3 THR X 150 LYS X 154 0 SHEET 2 GT 3 TYR X 196 HIS X 202 -1 O THR X 201 N THR X 150 SHEET 3 GT 3 SER X 205 VAL X 211 -1 O SER X 205 N HIS X 202 SHEET 1 GU 5 VAL Z 10 GLY Z 12 0 SHEET 2 GU 5 THR Z 106 VAL Z 110 1 O THR Z 109 N VAL Z 10 SHEET 3 GU 5 ASP Z 87 TYR Z 93 -1 N TYR Z 88 O THR Z 106 SHEET 4 GU 5 HIS Z 36 GLN Z 40 -1 N GLN Z 40 O ASP Z 87 SHEET 5 GU 5 LEU Z 48 ILE Z 50 -1 O ILE Z 50 N TRP Z 37 SHEET 1 GV 4 VAL Z 10 GLY Z 12 0 SHEET 2 GV 4 THR Z 106 VAL Z 110 1 O THR Z 109 N VAL Z 10 SHEET 3 GV 4 ASP Z 87 TYR Z 93 -1 N TYR Z 88 O THR Z 106 SHEET 4 GV 4 SER Z 100 VAL Z 101 -1 O VAL Z 101 N SER Z 92 SHEET 1 GW 3 VAL Z 18 THR Z 23 0 SHEET 2 GW 3 SER Z 72 ILE Z 77 -1 O ALA Z 73 N CYS Z 22 SHEET 3 GW 3 PHE Z 64 SER Z 69 -1 N SER Z 69 O SER Z 72 SHEET 1 GX 4 SER Z 119 PHE Z 123 0 SHEET 2 GX 4 ALA Z 135 PHE Z 144 -1 O SER Z 142 N SER Z 119 SHEET 3 GX 4 TYR Z 177 LEU Z 185 -1 O ALA Z 179 N ILE Z 141 SHEET 4 GX 4 GLU Z 165 LYS Z 171 -1 N THR Z 167 O SER Z 180 SHEET 1 GY 3 THR Z 150 LYS Z 154 0 SHEET 2 GY 3 TYR Z 196 HIS Z 202 -1 O THR Z 201 N THR Z 150 SHEET 3 GY 3 SER Z 205 VAL Z 211 -1 O LYS Z 209 N CYS Z 198 SHEET 1 GZ 5 VAL 2 10 GLY 2 12 0 SHEET 2 GZ 5 THR 2 106 VAL 2 110 1 O THR 2 109 N VAL 2 10 SHEET 3 GZ 5 ASP 2 87 TYR 2 93 -1 N TYR 2 88 O THR 2 106 SHEET 4 GZ 5 HIS 2 36 GLN 2 40 -1 N GLN 2 40 O ASP 2 87 SHEET 5 GZ 5 LEU 2 48 ILE 2 50 -1 O ILE 2 50 N TRP 2 37 SHEET 1 HA 4 VAL 2 10 GLY 2 12 0 SHEET 2 HA 4 THR 2 106 VAL 2 110 1 O THR 2 109 N VAL 2 10 SHEET 3 HA 4 ASP 2 87 TYR 2 93 -1 N TYR 2 88 O THR 2 106 SHEET 4 HA 4 SER 2 100 VAL 2 101 -1 O VAL 2 101 N SER 2 92 SHEET 1 HB 3 VAL 2 18 THR 2 23 0 SHEET 2 HB 3 SER 2 72 ILE 2 77 -1 O ALA 2 73 N CYS 2 22 SHEET 3 HB 3 PHE 2 64 SER 2 69 -1 N SER 2 69 O SER 2 72 SHEET 1 HC 4 SER 2 119 PHE 2 123 0 SHEET 2 HC 4 ALA 2 135 PHE 2 144 -1 O SER 2 142 N SER 2 119 SHEET 3 HC 4 TYR 2 177 LEU 2 185 -1 O ALA 2 179 N ILE 2 141 SHEET 4 HC 4 GLU 2 165 LYS 2 171 -1 N THR 2 167 O SER 2 180 SHEET 1 HD 3 THR 2 150 LYS 2 154 0 SHEET 2 HD 3 TYR 2 196 HIS 2 202 -1 O THR 2 201 N THR 2 150 SHEET 3 HD 3 SER 2 205 VAL 2 211 -1 O SER 2 205 N HIS 2 202 SHEET 1 HE 5 VAL 4 10 GLY 4 12 0 SHEET 2 HE 5 THR 4 106 VAL 4 110 1 O THR 4 109 N VAL 4 10 SHEET 3 HE 5 ASP 4 87 TYR 4 93 -1 N TYR 4 88 O THR 4 106 SHEET 4 HE 5 HIS 4 36 GLN 4 40 -1 N HIS 4 36 O GLN 4 91 SHEET 5 HE 5 LEU 4 48 ILE 4 50 -1 O ILE 4 50 N TRP 4 37 SHEET 1 HF 4 VAL 4 10 GLY 4 12 0 SHEET 2 HF 4 THR 4 106 VAL 4 110 1 O THR 4 109 N VAL 4 10 SHEET 3 HF 4 ASP 4 87 TYR 4 93 -1 N TYR 4 88 O THR 4 106 SHEET 4 HF 4 SER 4 100 VAL 4 101 -1 O VAL 4 101 N SER 4 92 SHEET 1 HG 3 VAL 4 18 THR 4 23 0 SHEET 2 HG 3 SER 4 72 ILE 4 77 -1 O ALA 4 73 N CYS 4 22 SHEET 3 HG 3 PHE 4 64 SER 4 69 -1 N SER 4 69 O SER 4 72 SHEET 1 HH 4 SER 4 119 PHE 4 123 0 SHEET 2 HH 4 ALA 4 135 PHE 4 144 -1 O SER 4 142 N SER 4 119 SHEET 3 HH 4 TYR 4 177 LEU 4 185 -1 O ALA 4 179 N ILE 4 141 SHEET 4 HH 4 GLU 4 165 LYS 4 171 -1 N THR 4 167 O SER 4 180 SHEET 1 HI 3 THR 4 150 LYS 4 154 0 SHEET 2 HI 3 TYR 4 196 HIS 4 202 -1 O THR 4 201 N THR 4 150 SHEET 3 HI 3 SER 4 205 VAL 4 211 -1 O LYS 4 209 N CYS 4 198 SHEET 1 HJ 5 VAL 6 10 GLY 6 12 0 SHEET 2 HJ 5 THR 6 106 VAL 6 110 1 O THR 6 109 N VAL 6 10 SHEET 3 HJ 5 ASP 6 87 TYR 6 93 -1 N TYR 6 88 O THR 6 106 SHEET 4 HJ 5 HIS 6 36 GLN 6 40 -1 N GLN 6 40 O ASP 6 87 SHEET 5 HJ 5 LEU 6 48 ILE 6 50 -1 O ILE 6 50 N TRP 6 37 SHEET 1 HK 4 VAL 6 10 GLY 6 12 0 SHEET 2 HK 4 THR 6 106 VAL 6 110 1 O THR 6 109 N VAL 6 10 SHEET 3 HK 4 ASP 6 87 TYR 6 93 -1 N TYR 6 88 O THR 6 106 SHEET 4 HK 4 SER 6 100 VAL 6 101 -1 O VAL 6 101 N SER 6 92 SHEET 1 HL 3 VAL 6 18 THR 6 23 0 SHEET 2 HL 3 SER 6 72 ILE 6 77 -1 O ALA 6 73 N CYS 6 22 SHEET 3 HL 3 PHE 6 64 SER 6 69 -1 N SER 6 69 O SER 6 72 SHEET 1 HM 4 SER 6 119 PHE 6 123 0 SHEET 2 HM 4 ALA 6 135 PHE 6 144 -1 O SER 6 142 N SER 6 119 SHEET 3 HM 4 TYR 6 177 LEU 6 185 -1 O LEU 6 185 N ALA 6 135 SHEET 4 HM 4 GLU 6 165 LYS 6 171 -1 N THR 6 167 O SER 6 180 SHEET 1 HN 3 THR 6 150 LYS 6 154 0 SHEET 2 HN 3 TYR 6 196 HIS 6 202 -1 O THR 6 201 N THR 6 150 SHEET 3 HN 3 SER 6 205 VAL 6 211 -1 O LYS 6 209 N CYS 6 198 SHEET 1 HO 5 VAL 8 10 GLY 8 12 0 SHEET 2 HO 5 THR 8 106 VAL 8 110 1 O THR 8 109 N VAL 8 10 SHEET 3 HO 5 ASP 8 87 TYR 8 93 -1 N TYR 8 88 O THR 8 106 SHEET 4 HO 5 HIS 8 36 GLN 8 40 -1 N HIS 8 36 O GLN 8 91 SHEET 5 HO 5 LEU 8 48 ILE 8 50 -1 O ILE 8 50 N TRP 8 37 SHEET 1 HP 4 VAL 8 10 GLY 8 12 0 SHEET 2 HP 4 THR 8 106 VAL 8 110 1 O THR 8 109 N VAL 8 10 SHEET 3 HP 4 ASP 8 87 TYR 8 93 -1 N TYR 8 88 O THR 8 106 SHEET 4 HP 4 SER 8 100 VAL 8 101 -1 O VAL 8 101 N SER 8 92 SHEET 1 HQ 3 VAL 8 18 THR 8 23 0 SHEET 2 HQ 3 SER 8 72 ILE 8 77 -1 O ALA 8 73 N CYS 8 22 SHEET 3 HQ 3 PHE 8 64 SER 8 69 -1 N SER 8 69 O SER 8 72 SHEET 1 HR 4 SER 8 119 PHE 8 123 0 SHEET 2 HR 4 ALA 8 135 PHE 8 144 -1 O SER 8 142 N SER 8 119 SHEET 3 HR 4 TYR 8 177 LEU 8 185 -1 O ALA 8 179 N ILE 8 141 SHEET 4 HR 4 GLU 8 165 LYS 8 171 -1 N THR 8 167 O SER 8 180 SHEET 1 HS 3 THR 8 150 LYS 8 154 0 SHEET 2 HS 3 TYR 8 196 HIS 8 202 -1 O THR 8 201 N THR 8 150 SHEET 3 HS 3 SER 8 205 VAL 8 211 -1 O SER 8 205 N HIS 8 202 SHEET 1 HT 5 VAL 0 10 GLY 0 12 0 SHEET 2 HT 5 THR 0 106 VAL 0 110 1 O THR 0 109 N VAL 0 10 SHEET 3 HT 5 ASP 0 87 TYR 0 93 -1 N TYR 0 88 O THR 0 106 SHEET 4 HT 5 HIS 0 36 GLN 0 40 -1 N GLN 0 40 O ASP 0 87 SHEET 5 HT 5 LEU 0 48 ILE 0 50 -1 O ILE 0 50 N TRP 0 37 SHEET 1 HU 4 VAL 0 10 GLY 0 12 0 SHEET 2 HU 4 THR 0 106 VAL 0 110 1 O THR 0 109 N VAL 0 10 SHEET 3 HU 4 ASP 0 87 TYR 0 93 -1 N TYR 0 88 O THR 0 106 SHEET 4 HU 4 SER 0 100 VAL 0 101 -1 O VAL 0 101 N SER 0 92 SHEET 1 HV 3 VAL 0 18 THR 0 23 0 SHEET 2 HV 3 SER 0 72 ILE 0 77 -1 O ALA 0 73 N CYS 0 22 SHEET 3 HV 3 PHE 0 64 SER 0 69 -1 N SER 0 69 O SER 0 72 SHEET 1 HW 4 SER 0 119 PHE 0 123 0 SHEET 2 HW 4 ALA 0 135 PHE 0 144 -1 O SER 0 142 N SER 0 119 SHEET 3 HW 4 TYR 0 177 LEU 0 185 -1 O ALA 0 179 N ILE 0 141 SHEET 4 HW 4 GLU 0 165 LYS 0 171 -1 N THR 0 167 O SER 0 180 SHEET 1 HX 3 THR 0 150 LYS 0 154 0 SHEET 2 HX 3 TYR 0 196 HIS 0 202 -1 O THR 0 201 N THR 0 150 SHEET 3 HX 3 SER 0 205 VAL 0 211 -1 O LYS 0 209 N CYS 0 198 SSBOND 1 CYS A 14 CYS A 466 1555 1555 2.03 SSBOND 2 CYS A 52 CYS A 277 1555 1555 2.04 SSBOND 3 CYS A 64 CYS A 76 1555 1555 2.03 SSBOND 4 CYS A 97 CYS A 139 1555 1555 2.03 SSBOND 5 CYS A 281 CYS A 305 1555 1555 2.04 SSBOND 6 CYS A 473 CYS A 477 1555 1555 2.04 SSBOND 7 CYS B 14 CYS B 466 1555 1555 2.03 SSBOND 8 CYS B 52 CYS B 277 1555 1555 2.04 SSBOND 9 CYS B 64 CYS B 76 1555 1555 2.03 SSBOND 10 CYS B 97 CYS B 139 1555 1555 2.03 SSBOND 11 CYS B 281 CYS B 305 1555 1555 2.04 SSBOND 12 CYS B 473 CYS B 477 1555 1555 2.03 SSBOND 13 CYS C 14 CYS C 466 1555 1555 2.02 SSBOND 14 CYS C 52 CYS C 277 1555 1555 2.03 SSBOND 15 CYS C 64 CYS C 76 1555 1555 2.03 SSBOND 16 CYS C 97 CYS C 139 1555 1555 2.05 SSBOND 17 CYS C 281 CYS C 305 1555 1555 2.04 SSBOND 18 CYS C 473 CYS C 477 1555 1555 2.03 SSBOND 19 CYS D 14 CYS D 466 1555 1555 2.03 SSBOND 20 CYS D 52 CYS D 277 1555 1555 2.03 SSBOND 21 CYS D 64 CYS D 76 1555 1555 2.04 SSBOND 22 CYS D 97 CYS D 139 1555 1555 2.04 SSBOND 23 CYS D 281 CYS D 305 1555 1555 2.03 SSBOND 24 CYS D 473 CYS D 477 1555 1555 2.03 SSBOND 25 CYS E 14 CYS E 466 1555 1555 2.03 SSBOND 26 CYS E 52 CYS E 277 1555 1555 2.02 SSBOND 27 CYS E 64 CYS E 76 1555 1555 2.04 SSBOND 28 CYS E 97 CYS E 139 1555 1555 2.04 SSBOND 29 CYS E 281 CYS E 305 1555 1555 2.03 SSBOND 30 CYS E 473 CYS E 477 1555 1555 2.04 SSBOND 31 CYS F 14 CYS F 466 1555 1555 2.02 SSBOND 32 CYS F 52 CYS F 277 1555 1555 2.03 SSBOND 33 CYS F 64 CYS F 76 1555 1555 2.03 SSBOND 34 CYS F 97 CYS F 139 1555 1555 2.03 SSBOND 35 CYS F 281 CYS F 305 1555 1555 2.03 SSBOND 36 CYS F 473 CYS F 477 1555 1555 2.02 SSBOND 37 CYS G 14 CYS G 466 1555 1555 2.02 SSBOND 38 CYS G 52 CYS G 277 1555 1555 2.02 SSBOND 39 CYS G 64 CYS G 76 1555 1555 2.03 SSBOND 40 CYS G 97 CYS G 139 1555 1555 2.03 SSBOND 41 CYS G 281 CYS G 305 1555 1555 2.04 SSBOND 42 CYS G 473 CYS G 477 1555 1555 2.03 SSBOND 43 CYS H 14 CYS H 466 1555 1555 2.02 SSBOND 44 CYS H 52 CYS H 277 1555 1555 2.04 SSBOND 45 CYS H 64 CYS H 76 1555 1555 2.04 SSBOND 46 CYS H 97 CYS H 139 1555 1555 2.03 SSBOND 47 CYS H 281 CYS H 305 1555 1555 2.04 SSBOND 48 CYS H 473 CYS H 477 1555 1555 2.03 SSBOND 49 CYS I 14 CYS I 466 1555 1555 2.03 SSBOND 50 CYS I 52 CYS I 277 1555 1555 2.03 SSBOND 51 CYS I 64 CYS I 76 1555 1555 2.03 SSBOND 52 CYS I 97 CYS I 139 1555 1555 2.03 SSBOND 53 CYS I 281 CYS I 305 1555 1555 2.04 SSBOND 54 CYS I 473 CYS I 477 1555 1555 2.03 SSBOND 55 CYS J 14 CYS J 466 1555 1555 2.03 SSBOND 56 CYS J 52 CYS J 277 1555 1555 2.04 SSBOND 57 CYS J 64 CYS J 76 1555 1555 2.03 SSBOND 58 CYS J 97 CYS J 139 1555 1555 2.03 SSBOND 59 CYS J 281 CYS J 305 1555 1555 2.04 SSBOND 60 CYS J 473 CYS J 477 1555 1555 2.03 SSBOND 61 CYS K 14 CYS K 466 1555 1555 2.02 SSBOND 62 CYS K 52 CYS K 277 1555 1555 2.03 SSBOND 63 CYS K 64 CYS K 76 1555 1555 2.04 SSBOND 64 CYS K 97 CYS K 139 1555 1555 2.03 SSBOND 65 CYS K 281 CYS K 305 1555 1555 2.06 SSBOND 66 CYS K 473 CYS K 477 1555 1555 2.05 SSBOND 67 CYS L 14 CYS L 466 1555 1555 2.03 SSBOND 68 CYS L 52 CYS L 277 1555 1555 2.04 SSBOND 69 CYS L 64 CYS L 76 1555 1555 2.05 SSBOND 70 CYS L 97 CYS L 139 1555 1555 2.03 SSBOND 71 CYS L 281 CYS L 305 1555 1555 2.03 SSBOND 72 CYS L 473 CYS L 477 1555 1555 2.03 SSBOND 73 CYS M 22 CYS M 96 1555 1555 2.04 SSBOND 74 CYS M 153 CYS M 209 1555 1555 2.02 SSBOND 75 CYS O 22 CYS O 96 1555 1555 2.04 SSBOND 76 CYS O 153 CYS O 209 1555 1555 2.03 SSBOND 77 CYS Q 22 CYS Q 96 1555 1555 2.03 SSBOND 78 CYS Q 153 CYS Q 209 1555 1555 2.03 SSBOND 79 CYS S 22 CYS S 96 1555 1555 2.03 SSBOND 80 CYS S 153 CYS S 209 1555 1555 2.03 SSBOND 81 CYS U 22 CYS U 96 1555 1555 2.03 SSBOND 82 CYS U 153 CYS U 209 1555 1555 2.03 SSBOND 83 CYS W 22 CYS W 96 1555 1555 2.04 SSBOND 84 CYS W 153 CYS W 209 1555 1555 2.04 SSBOND 85 CYS Y 22 CYS Y 96 1555 1555 2.04 SSBOND 86 CYS Y 153 CYS Y 209 1555 1555 2.03 SSBOND 87 CYS 1 22 CYS 1 96 1555 1555 2.04 SSBOND 88 CYS 1 153 CYS 1 209 1555 1555 2.03 SSBOND 89 CYS 3 22 CYS 3 96 1555 1555 2.03 SSBOND 90 CYS 3 153 CYS 3 209 1555 1555 2.03 SSBOND 91 CYS 5 22 CYS 5 96 1555 1555 2.03 SSBOND 92 CYS 5 153 CYS 5 209 1555 1555 2.03 SSBOND 93 CYS 7 22 CYS 7 96 1555 1555 2.03 SSBOND 94 CYS 7 153 CYS 7 209 1555 1555 2.03 SSBOND 95 CYS 9 22 CYS 9 96 1555 1555 2.05 SSBOND 96 CYS 9 153 CYS 9 209 1555 1555 2.03 SSBOND 97 CYS N 22 CYS N 90 1555 1555 2.03 SSBOND 98 CYS N 139 CYS N 198 1555 1555 2.04 SSBOND 99 CYS P 22 CYS P 90 1555 1555 2.03 SSBOND 100 CYS P 139 CYS P 198 1555 1555 2.04 SSBOND 101 CYS R 22 CYS R 90 1555 1555 2.02 SSBOND 102 CYS R 139 CYS R 198 1555 1555 2.03 SSBOND 103 CYS T 22 CYS T 90 1555 1555 2.03 SSBOND 104 CYS T 139 CYS T 198 1555 1555 2.03 SSBOND 105 CYS V 22 CYS V 90 1555 1555 2.03 SSBOND 106 CYS V 139 CYS V 198 1555 1555 2.03 SSBOND 107 CYS X 22 CYS X 90 1555 1555 2.03 SSBOND 108 CYS X 139 CYS X 198 1555 1555 2.03 SSBOND 109 CYS Z 22 CYS Z 90 1555 1555 2.03 SSBOND 110 CYS Z 139 CYS Z 198 1555 1555 2.03 SSBOND 111 CYS 2 22 CYS 2 90 1555 1555 2.03 SSBOND 112 CYS 2 139 CYS 2 198 1555 1555 2.04 SSBOND 113 CYS 4 22 CYS 4 90 1555 1555 2.03 SSBOND 114 CYS 4 139 CYS 4 198 1555 1555 2.03 SSBOND 115 CYS 6 22 CYS 6 90 1555 1555 2.03 SSBOND 116 CYS 6 139 CYS 6 198 1555 1555 2.03 SSBOND 117 CYS 8 22 CYS 8 90 1555 1555 2.02 SSBOND 118 CYS 8 139 CYS 8 198 1555 1555 2.03 SSBOND 119 CYS 0 22 CYS 0 90 1555 1555 2.03 SSBOND 120 CYS 0 139 CYS 0 198 1555 1555 2.04 LINK O4 NAG H 602 C1 BMA H 603 1555 1555 1.38 LINK O4 NAG D 602 C1 BMA D 603 1555 1555 1.38 LINK O4 NAG A 602 C1 BMA A 603 1555 1555 1.38 LINK O4 NAG G 616 C1 BMA G 617 1555 1555 1.38 LINK O4 NAG I 602 C1 BMA I 603 1555 1555 1.38 LINK O4 NAG F 602 C1 BMA F 603 1555 1555 1.38 LINK O4 NAG C 602 C1 BMA C 603 1555 1555 1.38 LINK O4 NAG E 602 C1 BMA E 603 1555 1555 1.38 LINK O4 NAG L 602 C1 BMA L 603 1555 1555 1.38 LINK O4 NAG K 602 C1 BMA K 603 1555 1555 1.38 LINK O4 NAG G 602 C1 BMA G 603 1555 1555 1.38 LINK O4 NAG B 602 C1 BMA B 603 1555 1555 1.38 LINK O4 NAG H 615 C1 NAG H 616 1555 1555 1.38 LINK O4 NAG A 616 C1 BMA A 617 1555 1555 1.38 LINK O4 NAG J 616 C1 BMA J 617 1555 1555 1.38 LINK O4 NAG C 616 C1 BMA C 617 1555 1555 1.38 LINK O4 NAG K 616 C1 BMA K 617 1555 1555 1.38 LINK O4 NAG J 602 C1 BMA J 603 1555 1555 1.38 LINK O4 NAG C 615 C1 NAG C 616 1555 1555 1.38 LINK O4 NAG D 616 C1 BMA D 617 1555 1555 1.38 LINK O4 NAG E 616 C1 BMA E 617 1555 1555 1.38 LINK O4 NAG I 616 C1 BMA I 617 1555 1555 1.38 LINK O4 NAG L 616 C1 BMA L 617 1555 1555 1.38 LINK O4 NAG H 616 C1 BMA H 617 1555 1555 1.38 LINK O4 NAG K 615 C1 NAG K 616 1555 1555 1.38 LINK O4 NAG F 616 C1 BMA F 617 1555 1555 1.38 LINK O4 NAG I 609 C1 NAG I 610 1555 1555 1.38 LINK O4 NAG L 615 C1 NAG L 616 1555 1555 1.38 LINK O4 NAG B 616 C1 BMA B 617 1555 1555 1.38 LINK O4 NAG D 601 C1 NAG D 602 1555 1555 1.38 LINK O4 NAG G 615 C1 NAG G 616 1555 1555 1.38 LINK O4 NAG I 615 C1 NAG I 616 1555 1555 1.38 LINK O4 NAG C 601 C1 NAG C 602 1555 1555 1.38 LINK O4 NAG D 615 C1 NAG D 616 1555 1555 1.38 LINK O4 NAG G 609 C1 NAG G 610 1555 1555 1.38 LINK O4 NAG K 601 C1 NAG K 602 1555 1555 1.38 LINK O4 NAG H 601 C1 NAG H 602 1555 1555 1.39 LINK O4 NAG J 615 C1 NAG J 616 1555 1555 1.39 LINK O4 NAG B 601 C1 NAG B 602 1555 1555 1.39 LINK O4 NAG L 601 C1 NAG L 602 1555 1555 1.39 LINK O4 NAG F 601 C1 NAG F 602 1555 1555 1.39 LINK O4 NAG J 609 C1 NAG J 610 1555 1555 1.39 LINK O4 NAG H 609 C1 NAG H 610 1555 1555 1.39 LINK O4 NAG A 615 C1 NAG A 616 1555 1555 1.39 LINK O4 NAG L 609 C1 NAG L 610 1555 1555 1.39 LINK O4 NAG B 615 C1 NAG B 616 1555 1555 1.39 LINK O4 NAG D 610 C1 BMA D 611 1555 1555 1.39 LINK O4 NAG K 609 C1 NAG K 610 1555 1555 1.39 LINK O4 NAG F 609 C1 NAG F 610 1555 1555 1.39 LINK O4 NAG B 609 C1 NAG B 610 1555 1555 1.39 LINK O4 NAG A 609 C1 NAG A 610 1555 1555 1.39 LINK O4 NAG F 610 C1 BMA F 611 1555 1555 1.39 LINK O4 NAG J 601 C1 NAG J 602 1555 1555 1.39 LINK O4 NAG D 609 C1 NAG D 610 1555 1555 1.39 LINK O4 NAG E 609 C1 NAG E 610 1555 1555 1.39 LINK O4 NAG E 615 C1 NAG E 616 1555 1555 1.39 LINK O4 NAG F 615 C1 NAG F 616 1555 1555 1.39 LINK O4 NAG A 601 C1 NAG A 602 1555 1555 1.39 LINK O4 NAG G 601 C1 NAG G 602 1555 1555 1.39 LINK O4 NAG I 601 C1 NAG I 602 1555 1555 1.39 LINK O4 NAG E 601 C1 NAG E 602 1555 1555 1.39 LINK O4 NAG C 609 C1 NAG C 610 1555 1555 1.39 LINK O4 NAG I 610 C1 BMA I 611 1555 1555 1.39 LINK O4 NAG B 610 C1 BMA B 611 1555 1555 1.39 LINK O4 NAG L 610 C1 BMA L 611 1555 1555 1.39 LINK O4 NAG G 610 C1 BMA G 611 1555 1555 1.39 LINK O4 NAG J 610 C1 BMA J 611 1555 1555 1.39 LINK O4 NAG C 610 C1 BMA C 611 1555 1555 1.39 LINK O4 NAG K 610 C1 BMA K 611 1555 1555 1.39 LINK O4 NAG H 610 C1 BMA H 611 1555 1555 1.39 LINK O4 NAG E 610 C1 BMA E 611 1555 1555 1.39 LINK O4 NAG A 610 C1 BMA A 611 1555 1555 1.39 LINK O3 MAN B 605 C1 MAN B 606 1555 1555 1.40 LINK O3 BMA I 603 C1 MAN I 604 1555 1555 1.40 LINK O3 BMA E 603 C1 MAN E 604 1555 1555 1.40 LINK O3 MAN C 605 C1 MAN C 606 1555 1555 1.40 LINK O3 MAN K 605 C1 MAN K 606 1555 1555 1.40 LINK O3 MAN J 605 C1 MAN J 606 1555 1555 1.40 LINK O3 MAN L 605 C1 MAN L 606 1555 1555 1.40 LINK O3 MAN H 605 C1 MAN H 606 1555 1555 1.40 LINK O6 MAN H 605 C1 MAN H 607 1555 1555 1.40 LINK O6 MAN G 605 C1 MAN G 607 1555 1555 1.40 LINK O3 BMA F 603 C1 MAN F 604 1555 1555 1.40 LINK O3 BMA C 603 C1 MAN C 604 1555 1555 1.40 LINK O3 BMA E 611 C1 MAN E 612 1555 1555 1.40 LINK O6 MAN B 605 C1 MAN B 607 1555 1555 1.40 LINK O6 MAN A 605 C1 MAN A 607 1555 1555 1.40 LINK O6 MAN E 605 C1 MAN E 607 1555 1555 1.40 LINK O3 MAN D 605 C1 MAN D 606 1555 1555 1.40 LINK O6 MAN C 605 C1 MAN C 607 1555 1555 1.40 LINK O3 MAN A 605 C1 MAN A 606 1555 1555 1.40 LINK O6 MAN D 605 C1 MAN D 607 1555 1555 1.40 LINK O6 MAN K 605 C1 MAN K 607 1555 1555 1.40 LINK O3 MAN G 605 C1 MAN G 606 1555 1555 1.40 LINK O6 MAN F 605 C1 MAN F 607 1555 1555 1.40 LINK O6 MAN J 605 C1 MAN J 607 1555 1555 1.40 LINK O6 MAN I 605 C1 MAN I 607 1555 1555 1.40 LINK O3 BMA H 603 C1 MAN H 604 1555 1555 1.40 LINK O3 BMA A 611 C1 MAN A 612 1555 1555 1.40 LINK O3 BMA A 603 C1 MAN A 604 1555 1555 1.40 LINK O6 MAN L 605 C1 MAN L 607 1555 1555 1.40 LINK O3 MAN E 605 C1 MAN E 606 1555 1555 1.40 LINK O3 BMA B 603 C1 MAN B 604 1555 1555 1.40 LINK O3 MAN I 605 C1 MAN I 606 1555 1555 1.40 LINK O3 MAN F 605 C1 MAN F 606 1555 1555 1.40 LINK O3 BMA L 603 C1 MAN L 604 1555 1555 1.40 LINK O3 BMA H 611 C1 MAN H 612 1555 1555 1.40 LINK O3 BMA K 603 C1 MAN K 604 1555 1555 1.40 LINK O3 BMA B 611 C1 MAN B 612 1555 1555 1.40 LINK O3 BMA D 603 C1 MAN D 604 1555 1555 1.40 LINK O3 BMA G 603 C1 MAN G 604 1555 1555 1.40 LINK O6 BMA J 611 C1 MAN J 614 1555 1555 1.40 LINK O6 BMA C 611 C1 MAN C 614 1555 1555 1.40 LINK O3 BMA G 611 C1 MAN G 612 1555 1555 1.40 LINK O3 BMA J 611 C1 MAN J 612 1555 1555 1.40 LINK O3 BMA L 611 C1 MAN L 612 1555 1555 1.40 LINK O3 BMA K 611 C1 MAN K 612 1555 1555 1.40 LINK O3 BMA J 603 C1 MAN J 604 1555 1555 1.40 LINK O6 BMA F 603 C1 MAN F 605 1555 1555 1.40 LINK O6 BMA I 611 C1 MAN I 614 1555 1555 1.40 LINK O6 BMA L 603 C1 MAN L 605 1555 1555 1.40 LINK O6 BMA J 603 C1 MAN J 605 1555 1555 1.40 LINK O6 BMA B 611 C1 MAN B 614 1555 1555 1.40 LINK O6 BMA I 603 C1 MAN I 605 1555 1555 1.40 LINK O6 BMA A 611 C1 MAN A 614 1555 1555 1.40 LINK O3 BMA C 611 C1 MAN C 612 1555 1555 1.40 LINK O3 BMA I 611 C1 MAN I 612 1555 1555 1.40 LINK O6 BMA D 611 C1 MAN D 614 1555 1555 1.40 LINK O6 BMA D 603 C1 MAN D 605 1555 1555 1.40 LINK O6 BMA G 611 C1 MAN G 614 1555 1555 1.40 LINK O3 BMA F 611 C1 MAN F 612 1555 1555 1.40 LINK O6 BMA E 611 C1 MAN E 614 1555 1555 1.40 LINK O3 BMA D 611 C1 MAN D 612 1555 1555 1.40 LINK O6 BMA H 603 C1 MAN H 605 1555 1555 1.40 LINK O6 BMA E 603 C1 MAN E 605 1555 1555 1.40 LINK O6 BMA K 611 C1 MAN K 614 1555 1555 1.40 LINK O6 BMA L 611 C1 MAN L 614 1555 1555 1.40 LINK O2 MAN E 612 C1 MAN E 613 1555 1555 1.40 LINK O6 BMA A 603 C1 MAN A 605 1555 1555 1.40 LINK O6 BMA H 611 C1 MAN H 614 1555 1555 1.40 LINK O6 BMA C 603 C1 MAN C 605 1555 1555 1.40 LINK O6 BMA F 611 C1 MAN F 614 1555 1555 1.40 LINK O2 MAN L 612 C1 MAN L 613 1555 1555 1.40 LINK O6 BMA K 603 C1 MAN K 605 1555 1555 1.40 LINK O2 MAN H 612 C1 MAN H 613 1555 1555 1.40 LINK O6 BMA G 603 C1 MAN G 605 1555 1555 1.40 LINK O2 MAN D 612 C1 MAN D 613 1555 1555 1.40 LINK O6 BMA B 603 C1 MAN B 605 1555 1555 1.40 LINK O2 MAN B 612 C1 MAN B 613 1555 1555 1.41 LINK O2 MAN A 612 C1 MAN A 613 1555 1555 1.41 LINK O2 MAN F 612 C1 MAN F 613 1555 1555 1.41 LINK O2 MAN C 612 C1 MAN C 613 1555 1555 1.41 LINK O2 MAN K 612 C1 MAN K 613 1555 1555 1.41 LINK O2 MAN I 612 C1 MAN I 613 1555 1555 1.41 LINK O2 MAN G 612 C1 MAN G 613 1555 1555 1.41 LINK O2 MAN J 612 C1 MAN J 613 1555 1555 1.41 LINK ND2 ASN H 483 C1 NAG H 618 1555 1555 1.44 LINK ND2 ASN H 285 C1 NAG H 601 1555 1555 1.45 LINK ND2 ASN B 285 C1 NAG B 601 1555 1555 1.45 LINK ND2 ASN L 285 C1 NAG L 601 1555 1555 1.45 LINK ND2 ASN F 285 C1 NAG F 601 1555 1555 1.45 LINK ND2 ASN J 285 C1 NAG J 601 1555 1555 1.45 LINK ND2 ASN I 285 C1 NAG I 601 1555 1555 1.45 LINK ND2 ASN G 285 C1 NAG G 601 1555 1555 1.45 LINK ND2 ASN D 285 C1 NAG D 601 1555 1555 1.45 LINK ND2 ASN J 38 C1 NAG J 615 1555 1555 1.45 LINK ND2 ASN A 285 C1 NAG A 601 1555 1555 1.45 LINK ND2 ASN H 38 C1 NAG H 615 1555 1555 1.45 LINK ND2 ASN K 285 C1 NAG K 601 1555 1555 1.45 LINK ND2 ASN E 285 C1 NAG E 601 1555 1555 1.45 LINK ND2 ASN G 38 C1 NAG G 615 1555 1555 1.45 LINK ND2 ASN E 38 C1 NAG E 615 1555 1555 1.45 LINK ND2 ASN B 38 C1 NAG B 615 1555 1555 1.45 LINK ND2 ASN C 285 C1 NAG C 601 1555 1555 1.45 LINK ND2 ASN K 38 C1 NAG K 615 1555 1555 1.45 LINK ND2 ASN F 38 C1 NAG F 615 1555 1555 1.45 LINK ND2 ASN H 81 C1 NAG H 608 1555 1555 1.45 LINK ND2 ASN L 81 C1 NAG L 608 1555 1555 1.45 LINK ND2 ASN C 38 C1 NAG C 615 1555 1555 1.45 LINK ND2 ASN A 38 C1 NAG A 615 1555 1555 1.45 LINK ND2 ASN I 483 C1 NAG I 618 1555 1555 1.45 LINK ND2 ASN L 38 C1 NAG L 615 1555 1555 1.45 LINK ND2 ASN D 81 C1 NAG D 608 1555 1555 1.45 LINK ND2 ASN F 81 C1 NAG F 608 1555 1555 1.45 LINK ND2 ASN G 81 C1 NAG G 608 1555 1555 1.45 LINK ND2 ASN D 38 C1 NAG D 615 1555 1555 1.45 LINK ND2 ASN E 81 C1 NAG E 608 1555 1555 1.45 LINK ND2 ASN A 81 C1 NAG A 608 1555 1555 1.45 LINK ND2 ASN C 81 C1 NAG C 608 1555 1555 1.45 LINK ND2 ASN K 81 C1 NAG K 608 1555 1555 1.45 LINK ND2 ASN B 81 C1 NAG B 608 1555 1555 1.45 LINK ND2 ASN J 81 C1 NAG J 608 1555 1555 1.45 LINK ND2 ASN C 483 C1 NAG C 618 1555 1555 1.45 LINK ND2 ASN I 38 C1 NAG I 615 1555 1555 1.45 LINK ND2 ASN I 81 C1 NAG I 608 1555 1555 1.45 LINK ND2 ASN K 483 C1 NAG K 618 1555 1555 1.45 LINK ND2 ASN G 483 C1 NAG G 618 1555 1555 1.45 LINK ND2 ASN F 483 C1 NAG F 618 1555 1555 1.45 LINK ND2 ASN B 483 C1 NAG B 618 1555 1555 1.45 LINK ND2 ASN J 483 C1 NAG J 618 1555 1555 1.45 LINK ND2 ASN L 483 C1 NAG L 618 1555 1555 1.45 LINK ND2 ASN E 483 C1 NAG E 618 1555 1555 1.45 LINK ND2 ASN D 483 C1 NAG D 618 1555 1555 1.45 LINK ND2 ASN A 483 C1 NAG A 618 1555 1555 1.45 LINK ND2 ASN H 165 C1 NAG H 609 1555 1555 1.45 LINK ND2 ASN J 165 C1 NAG J 609 1555 1555 1.45 LINK ND2 ASN L 165 C1 NAG L 609 1555 1555 1.45 LINK ND2 ASN F 165 C1 NAG F 609 1555 1555 1.45 LINK ND2 ASN G 165 C1 NAG G 609 1555 1555 1.45 LINK ND2 ASN B 165 C1 NAG B 609 1555 1555 1.45 LINK ND2 ASN C 165 C1 NAG C 609 1555 1555 1.45 LINK ND2 ASN K 165 C1 NAG K 609 1555 1555 1.45 LINK ND2 ASN I 165 C1 NAG I 609 1555 1555 1.45 LINK ND2 ASN D 165 C1 NAG D 609 1555 1555 1.45 LINK ND2 ASN E 165 C1 NAG E 609 1555 1555 1.45 LINK ND2 ASN A 165 C1 NAG A 609 1555 1555 1.45 CISPEP 1 ASN A 54 PRO A 55 0 -0.11 CISPEP 2 ASN B 54 PRO B 55 0 -0.16 CISPEP 3 ASN C 54 PRO C 55 0 -0.19 CISPEP 4 ASN D 54 PRO D 55 0 -0.07 CISPEP 5 ASN E 54 PRO E 55 0 -0.12 CISPEP 6 ASN F 54 PRO F 55 0 -0.13 CISPEP 7 ASN G 54 PRO G 55 0 -0.21 CISPEP 8 ASN H 54 PRO H 55 0 -0.20 CISPEP 9 ASN I 54 PRO I 55 0 -0.15 CISPEP 10 ASN J 54 PRO J 55 0 -0.12 CISPEP 11 ASN K 54 PRO K 55 0 -0.13 CISPEP 12 ASN L 54 PRO L 55 0 -0.16 CISPEP 13 PHE M 159 PRO M 160 0 -0.35 CISPEP 14 GLU M 161 PRO M 162 0 -0.33 CISPEP 15 PHE O 159 PRO O 160 0 -0.46 CISPEP 16 GLU O 161 PRO O 162 0 -0.33 CISPEP 17 PHE Q 159 PRO Q 160 0 -0.28 CISPEP 18 GLU Q 161 PRO Q 162 0 -0.45 CISPEP 19 PHE S 159 PRO S 160 0 -0.56 CISPEP 20 GLU S 161 PRO S 162 0 -0.29 CISPEP 21 PHE U 159 PRO U 160 0 -0.26 CISPEP 22 GLU U 161 PRO U 162 0 -0.34 CISPEP 23 PHE W 159 PRO W 160 0 -0.53 CISPEP 24 GLU W 161 PRO W 162 0 -0.42 CISPEP 25 PHE Y 159 PRO Y 160 0 -0.48 CISPEP 26 GLU Y 161 PRO Y 162 0 -0.40 CISPEP 27 PHE 1 159 PRO 1 160 0 -2.23 CISPEP 28 GLU 1 161 PRO 1 162 0 -0.38 CISPEP 29 PHE 3 159 PRO 3 160 0 -0.55 CISPEP 30 GLU 3 161 PRO 3 162 0 -0.37 CISPEP 31 PHE 5 159 PRO 5 160 0 -0.53 CISPEP 32 GLU 5 161 PRO 5 162 0 -0.31 CISPEP 33 PHE 7 159 PRO 7 160 0 -0.27 CISPEP 34 GLU 7 161 PRO 7 162 0 -0.43 CISPEP 35 PHE 9 159 PRO 9 160 0 -0.41 CISPEP 36 GLU 9 161 PRO 9 162 0 -0.44 CISPEP 37 TYR N 145 PRO N 146 0 -0.22 CISPEP 38 TYR P 145 PRO P 146 0 -0.28 CISPEP 39 TYR R 145 PRO R 146 0 -0.23 CISPEP 40 TYR T 145 PRO T 146 0 -0.16 CISPEP 41 TYR V 145 PRO V 146 0 -0.26 CISPEP 42 TYR X 145 PRO X 146 0 -0.28 CISPEP 43 TYR Z 145 PRO Z 146 0 -0.14 CISPEP 44 TYR 2 145 PRO 2 146 0 -0.17 CISPEP 45 TYR 4 145 PRO 4 146 0 -0.23 CISPEP 46 TYR 6 145 PRO 6 146 0 -0.21 CISPEP 47 TYR 8 145 PRO 8 146 0 -0.12 CISPEP 48 TYR 0 145 PRO 0 146 0 -0.22 SITE 1 AC1 3 ASN A 38 ALA A 39 THR A 40 SITE 1 AC2 2 ASN A 81 PHE A 120 SITE 1 AC3 6 ASN A 165 THR A 167 SER C 219 TRP C 222 SITE 2 AC3 6 SER C 227 GLN Q 3 SITE 1 AC4 9 ASN A 285 VAL A 297 LYS A 299 ASP M 55 SITE 2 AC4 9 GLY M 56 GLN M 57 ARG M 103 GLY M 104 SITE 3 AC4 9 MET M 106 SITE 1 AC5 2 GLU A 479 ASN A 483 SITE 1 AC6 3 ASN B 38 ALA B 39 THR B 40 SITE 1 AC7 2 ASN B 81 PHE B 120 SITE 1 AC8 5 SER A 219 TRP A 222 SER A 227 ASN B 165 SITE 2 AC8 5 THR B 167 SITE 1 AC9 10 ASN B 285 VAL B 297 LYS B 299 ASP O 55 SITE 2 AC9 10 GLY O 56 GLN O 57 THR O 58 ARG O 103 SITE 3 AC9 10 GLY O 104 MET O 106 SITE 1 BC1 2 GLU B 479 ASN B 483 SITE 1 BC2 3 ASN C 38 ALA C 39 THR C 40 SITE 1 BC3 2 ASN C 81 PHE C 120 SITE 1 BC4 5 SER B 219 TRP B 222 SER B 227 ASN C 165 SITE 2 BC4 5 THR C 167 SITE 1 BC5 5 ASN C 285 LYS C 299 ASP Q 55 ARG Q 103 SITE 2 BC5 5 GLY Q 104 SITE 1 BC6 2 GLU C 479 ASN C 483 SITE 1 BC7 3 ASN D 38 ALA D 39 THR D 40 SITE 1 BC8 2 ASN D 81 PHE D 120 SITE 1 BC9 5 ASN D 165 THR D 167 SER F 219 TRP F 222 SITE 2 BC9 5 SER F 227 SITE 1 CC1 7 ASN D 285 LYS D 299 ASP S 55 GLN S 57 SITE 2 CC1 7 THR S 58 ARG S 103 GLY S 104 SITE 1 CC2 2 GLU D 479 ASN D 483 SITE 1 CC3 3 ASN E 38 ALA E 39 THR E 40 SITE 1 CC4 2 ASN E 81 PHE E 120 SITE 1 CC5 5 SER D 219 TRP D 222 SER D 227 ASN E 165 SITE 2 CC5 5 THR E 167 SITE 1 CC6 8 ASN E 285 VAL E 297 LYS E 299 TYR U 54 SITE 2 CC6 8 ASP U 55 GLN U 57 ARG U 103 GLY U 104 SITE 1 CC7 2 GLU E 479 ASN E 483 SITE 1 CC8 3 ASN F 38 ALA F 39 THR F 40 SITE 1 CC9 2 ASN F 81 PHE F 120 SITE 1 DC1 6 SER E 219 TRP E 222 SER E 227 ASN F 165 SITE 2 DC1 6 THR F 167 GLN U 3 SITE 1 DC2 6 ASN F 285 LYS F 299 ASP W 55 GLN W 57 SITE 2 DC2 6 ARG W 103 GLY W 104 SITE 1 DC3 2 GLU F 479 ASN F 483 SITE 1 DC4 3 ASN G 38 ALA G 39 THR G 40 SITE 1 DC5 2 ASN G 81 PHE G 120 SITE 1 DC6 5 ASN G 165 THR G 167 SER I 219 TRP I 222 SITE 2 DC6 5 SER I 227 SITE 1 DC7 6 ASN G 285 LYS G 299 ASP Y 55 GLN Y 57 SITE 2 DC7 6 ARG Y 103 GLY Y 104 SITE 1 DC8 2 GLU G 479 ASN G 483 SITE 1 DC9 3 ASN H 38 ALA H 39 THR H 40 SITE 1 EC1 4 SER 8 127 GLN 8 131 ASN H 81 PHE H 120 SITE 1 EC2 6 SER G 219 TRP G 222 SER G 227 ASN H 165 SITE 2 EC2 6 THR H 167 GLN Y 3 SITE 1 EC3 8 ASP 1 55 GLY 1 56 GLN 1 57 ARG 1 103 SITE 2 EC3 8 GLY 1 104 ASN H 285 VAL H 297 LYS H 299 SITE 1 EC4 3 SER H 480 ASN H 483 ARG V 194 SITE 1 EC5 3 ASN I 38 ALA I 39 THR I 40 SITE 1 EC6 2 ASN I 81 PHE I 120 SITE 1 EC7 5 SER H 219 TRP H 222 SER H 227 ASN I 165 SITE 2 EC7 5 THR I 167 SITE 1 EC8 6 ASP 3 55 ARG 3 103 GLY 3 104 ASN I 285 SITE 2 EC8 6 VAL I 297 LYS I 299 SITE 1 EC9 2 GLU I 479 ASN I 483 SITE 1 FC1 3 ASN J 38 ALA J 39 THR J 40 SITE 1 FC2 2 ASN J 81 PHE J 120 SITE 1 FC3 4 ASN J 165 THR J 167 SER L 219 TRP L 222 SITE 1 FC4 10 ASP 5 55 GLY 5 56 GLN 5 57 THR 5 58 SITE 2 FC4 10 ARG 5 103 GLY 5 104 MET 5 106 ASN J 285 SITE 3 FC4 10 VAL J 297 LYS J 299 SITE 1 FC5 2 GLU J 479 ASN J 483 SITE 1 FC6 3 ASN K 38 ALA K 39 THR K 40 SITE 1 FC7 2 ASN K 81 PHE K 120 SITE 1 FC8 5 SER J 219 TRP J 222 SER J 227 ASN K 165 SITE 2 FC8 5 THR K 167 SITE 1 FC9 10 ASP 7 55 GLY 7 56 GLN 7 57 THR 7 58 SITE 2 FC9 10 ARG 7 103 GLY 7 104 MET 7 106 ASN K 285 SITE 3 FC9 10 VAL K 297 LYS K 299 SITE 1 GC1 2 GLU K 479 ASN K 483 SITE 1 GC2 3 ASN L 38 ALA L 39 THR L 40 SITE 1 GC3 2 ASN L 81 PHE L 120 SITE 1 GC4 5 SER K 219 TRP K 222 SER K 227 ASN L 165 SITE 2 GC4 5 THR L 167 SITE 1 GC5 9 ASP 9 55 GLN 9 57 THR 9 58 ARG 9 103 SITE 2 GC5 9 GLY 9 104 MET 9 106 ASN L 285 VAL L 297 SITE 3 GC5 9 LYS L 299 SITE 1 GC6 2 GLU L 479 ASN L 483 CRYST1 391.037 241.173 223.214 90.00 123.62 90.00 C 1 2 1 48 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.002557 0.000000 0.001700 0.00000 SCALE2 0.000000 0.004146 0.000000 0.00000 SCALE3 0.000000 0.000000 0.005380 0.00000