REMARK 2 REMARK 2 RESOLUTION. 2.79 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX (PHENIX.REFINE: DEV_1241) REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE- REMARK 3 : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO, REMARK 3 : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL REMARK 3 : MORIARTY,REETAL PAI,RANDY READ,JANE REMARK 3 : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM REMARK 3 : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH, REMARK 3 : LAURENT STORONI,TOM TERWILLIGER,PETER REMARK 3 : ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : ML REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.79 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 38.40 REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.490 REMARK 3 COMPLETENESS FOR RANGE (%) : 95.8 REMARK 3 NUMBER OF REFLECTIONS : 25028 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : 0.228 REMARK 3 R VALUE (WORKING SET) : 0.227 REMARK 3 FREE R VALUE : 0.256 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.010 REMARK 3 FREE R VALUE TEST SET COUNT : 1255 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 1 38.4238 - 5.7890 0.98 2910 153 0.2071 0.2334 REMARK 3 2 5.7890 - 4.5973 0.98 2740 144 0.2069 0.2266 REMARK 3 3 4.5973 - 4.0169 0.99 2745 147 0.1844 0.2223 REMARK 3 4 4.0169 - 3.6499 0.99 2720 143 0.2052 0.2396 REMARK 3 5 3.6499 - 3.3885 0.99 2701 142 0.2398 0.2946 REMARK 3 6 3.3885 - 3.1888 0.98 2669 142 0.2622 0.2778 REMARK 3 7 3.1888 - 3.0292 0.98 2680 141 0.2853 0.3085 REMARK 3 8 3.0292 - 2.8974 0.93 2483 130 0.3158 0.3074 REMARK 3 9 2.8974 - 2.7900 0.79 2125 113 0.3680 0.4126 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL REMARK 3 SOLVENT RADIUS : 1.11 REMARK 3 SHRINKAGE RADIUS : 0.90 REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.430 REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 28.160 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : 0.005 4643 REMARK 3 ANGLE : 0.725 6298 REMARK 3 CHIRALITY : 0.052 723 REMARK 3 PLANARITY : 0.003 783 REMARK 3 DIHEDRAL : 12.219 1624 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 5 REMARK 3 TLS GROUP : 1 REMARK 3 SELECTION: chain 'A' and (resid 858 through 1023 ) REMARK 3 ORIGIN FOR THE GROUP (A): -16.0036 -29.6026 -77.6145 REMARK 3 T TENSOR REMARK 3 T11: 0.4018 T22: 0.2411 REMARK 3 T33: 0.4333 T12: 0.0312 REMARK 3 T13: -0.0044 T23: -0.0144 REMARK 3 L TENSOR REMARK 3 L11: 4.5845 L22: 5.1656 REMARK 3 L33: 2.2186 L12: 4.1714 REMARK 3 L13: 0.9858 L23: 0.5688 REMARK 3 S TENSOR REMARK 3 S11: 0.1056 S12: 0.1973 S13: -0.1477 REMARK 3 S21: 0.3608 S22: 0.0559 S23: 0.0538 REMARK 3 S31: 0.1606 S32: 0.1057 S33: -0.1394 REMARK 3 TLS GROUP : 2 REMARK 3 SELECTION: chain 'A' and (resid 1024 through 1342 ) REMARK 3 ORIGIN FOR THE GROUP (A): -4.2045 -13.9949 -39.3775 REMARK 3 T TENSOR REMARK 3 T11: 0.3517 T22: 0.4847 REMARK 3 T33: 0.2475 T12: 0.0010 REMARK 3 T13: 0.0224 T23: -0.0556 REMARK 3 L TENSOR REMARK 3 L11: 2.4386 L22: 1.5743 REMARK 3 L33: 3.8238 L12: 0.3646 REMARK 3 L13: 0.0447 L23: -1.0339 REMARK 3 S TENSOR REMARK 3 S11: 0.0209 S12: -0.3538 S13: 0.0208 REMARK 3 S21: 0.0289 S22: -0.0362 S23: 0.0340 REMARK 3 S31: 0.0471 S32: -0.2127 S33: 0.0005 REMARK 3 TLS GROUP : 3 REMARK 3 SELECTION: chain 'B' and (resid 1 through 52 ) REMARK 3 ORIGIN FOR THE GROUP (A): -1.2821 -17.4503 1.8354 REMARK 3 T TENSOR REMARK 3 T11: 0.3812 T22: 1.1486 REMARK 3 T33: 0.4178 T12: -0.0304 REMARK 3 T13: -0.0621 T23: -0.0106 REMARK 3 L TENSOR REMARK 3 L11: 1.4410 L22: 1.8855 REMARK 3 L33: 5.5909 L12: -0.3224 REMARK 3 L13: -1.6450 L23: 1.3926 REMARK 3 S TENSOR REMARK 3 S11: 0.0075 S12: -0.2903 S13: 0.0155 REMARK 3 S21: 0.1620 S22: 0.1193 S23: 0.1363 REMARK 3 S31: 0.0896 S32: -0.3307 S33: -0.1211 REMARK 3 TLS GROUP : 4 REMARK 3 SELECTION: chain 'B' and (resid 53 through 76 ) REMARK 3 ORIGIN FOR THE GROUP (A): 8.1521 -15.9804 -0.2069 REMARK 3 T TENSOR REMARK 3 T11: 0.5171 T22: 0.9639 REMARK 3 T33: 0.4409 T12: 0.0187 REMARK 3 T13: -0.1121 T23: -0.0658 REMARK 3 L TENSOR REMARK 3 L11: 8.6225 L22: 1.6358 REMARK 3 L33: 6.5781 L12: -1.2800 REMARK 3 L13: -3.4838 L23: -0.3136 REMARK 3 S TENSOR REMARK 3 S11: -0.2924 S12: -0.4328 S13: -0.2852 REMARK 3 S21: 0.5865 S22: -0.2638 S23: -0.2467 REMARK 3 S31: 0.2826 S32: 0.2713 S33: 0.5667 REMARK 3 TLS GROUP : 5 REMARK 3 SELECTION: chain 'B' and (resid 77 through 120 ) REMARK 3 ORIGIN FOR THE GROUP (A): -2.0410 -15.7060 1.1698 REMARK 3 T TENSOR REMARK 3 T11: 0.4209 T22: 1.0532 REMARK 3 T33: 0.4754 T12: 0.0224 REMARK 3 T13: -0.0948 T23: -0.0769 REMARK 3 L TENSOR REMARK 3 L11: 2.3539 L22: 2.1111 REMARK 3 L33: 4.8988 L12: -1.0458 REMARK 3 L13: -1.3507 L23: 0.4846 REMARK 3 S TENSOR REMARK 3 S11: -0.3274 S12: -0.4314 S13: 0.2469 REMARK 3 S21: 0.4123 S22: 0.1307 S23: -0.1248 REMARK 3 S31: 0.0759 S32: -0.2101 S33: 0.2064 REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 4LDE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-JUL-13. REMARK 100 THE RCSB ID CODE IS RCSB080489. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 13-DEC-12 REMARK 200 TEMPERATURE (KELVIN) : 78 REMARK 200 PH : 6.5 REMARK 200 NUMBER OF CRYSTALS USED : 7 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : APS REMARK 200 BEAMLINE : 23-ID-B REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.033 REMARK 200 MONOCHROMATOR : DOUBLE CRYSTAL CRYO-COOLED REMARK 200 SI(111) REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : CCD REMARK 200 DETECTOR MANUFACTURER : MARMOSAIC 300 MM CCD REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 REMARK 200 DATA SCALING SOFTWARE : PHENIX (PHENIX.REFINE: DEV_1241) REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 25028 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.790 REMARK 200 RESOLUTION RANGE LOW (A) : 38.400 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 95.8 REMARK 200 DATA REDUNDANCY : 3.900 REMARK 200 R MERGE (I) : 0.17500 REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 4.5000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.80 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.90 REMARK 200 COMPLETENESS FOR SHELL (%) : 81.9 REMARK 200 DATA REDUNDANCY IN SHELL : 2.90 REMARK 200 R MERGE FOR SHELL (I) : 0.58400 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 1.800 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: PDB ENTRY 3P0G REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 67.35 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.77 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM MES PH 6.2-6.7, 40-100 MM REMARK 280 AMMONIUM PHOSPHATE DIBASIC, 18-24% PEG400, LIPIDIC CUBIC PHASE, REMARK 280 TEMPERATURE 293K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X+1/2,-Y,Z+1/2 REMARK 290 3555 -X,Y+1/2,-Z+1/2 REMARK 290 4555 X+1/2,-Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 24.83500 REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 151.55000 REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 33.24000 REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 151.55000 REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 24.83500 REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 33.24000 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 TOTAL BURIED SURFACE AREA: 2330 ANGSTROM**2 REMARK 350 SURFACE AREA OF THE COMPLEX: 28500 ANGSTROM**2 REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -18.0 KCAL/MOL REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ASP A 852 REMARK 465 TYR A 853 REMARK 465 LYS A 854 REMARK 465 ASP A 855 REMARK 465 ASP A 856 REMARK 465 ASP A 857 REMARK 465 LYS A 1260 REMARK 465 ILE A 1261 REMARK 465 ASP A 1262 REMARK 465 ARG A 1343 REMARK 465 ARG A 1344 REMARK 465 SER A 1345 REMARK 465 SER A 1346 REMARK 465 LEU A 1347 REMARK 465 LYS A 1348 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ASP A 858 CG OD1 OD2 REMARK 470 LEU A 862 CG CD1 CD2 REMARK 470 LYS A 913 CD CE NZ REMARK 470 LYS A1060 CG CD CE NZ REMARK 470 GLU A1062 CG CD OE1 OE2 REMARK 470 LYS A1149 CG CD CE NZ REMARK 470 PHE A1223 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLN A1224 CG CD OE1 NE2 REMARK 470 GLN A1231 CG CD OE1 NE2 REMARK 470 LYS A1263 CG CD CE NZ REMARK 470 PHE A1264 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS A1270 CG CD CE NZ REMARK 470 GLN B 1 CG CD OE1 NE2 REMARK 470 GLN B 13 CG CD OE1 NE2 REMARK 470 SER B 25 OG REMARK 470 SER B 120 OG REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OH TYR B 37 NZ LYS B 98 2.07 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PHE A 864 54.79 73.11 REMARK 500 ASP A 885 -165.49 -76.97 REMARK 500 ARG A 990 77.36 -103.05 REMARK 500 GLN A1065 48.52 -93.64 REMARK 500 LYS A1097 -12.44 64.78 REMARK 500 SER A1165 -80.84 -122.64 REMARK 500 CYS A1191 31.11 -141.24 REMARK 500 PHE A1208 -56.46 -128.95 REMARK 500 ALA A1265 -149.46 -107.36 REMARK 500 ASN A1301 1.53 59.75 REMARK 500 PRO B 41 107.72 -54.66 REMARK 500 VAL B 48 -70.32 -97.49 REMARK 500 ASN B 73 -73.24 -61.19 REMARK 500 ALA B 91 -167.95 -166.81 REMARK 500 PHE B 100 56.47 -97.60 REMARK 500 ILE B 103 -50.74 73.50 REMARK 500 SER B 119 98.49 -63.01 REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 1WV A 1403 REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 NA A1402 NA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS A1184 O REMARK 620 2 ASN A1103 OD1 134.7 REMARK 620 3 CYS A1190 O 102.3 117.8 REMARK 620 4 HOH A1502 O 91.7 102.6 97.2 REMARK 620 5 GLU A1187 O 82.1 73.6 96.6 165.8 REMARK 620 N 1 2 3 4 REMARK 650 REMARK 650 HELIX REMARK 650 DETERMINATION METHOD: AUTHOR DETERMINED REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE P0G A 1401 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 1402 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE 1WV A 1403 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 4LDL RELATED DB: PDB REMARK 900 THE SAME PROTEIN COMPLEXED TO HYDROXYBENZYLISOPROTERENOL REMARK 900 RELATED ID: 4LDO RELATED DB: PDB REMARK 900 THE SAME PROTEIN BOUND TO ADRENALINE AND AN ENGINEERED REMARK 900 NANOBODY