HEADER VIRAL PROTEIN 08-FEB-18 6CDE TITLE CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY TITLE 2 VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES TITLE 3 VRC03 AND PGT122 COMPND MOL_ID: 1; COMPND 2 MOLECULE: VFP20.01 HEAVY CHAIN; COMPND 3 CHAIN: h, H, 3; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: VFP20.01 LIGHT CHAIN; COMPND 7 CHAIN: l, L, 4; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: PGT122 HEAVY CHAIN; COMPND 11 CHAIN: M, m, 7; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: PGT122 LIGHT CHAIN; COMPND 15 CHAIN: N, n, 8; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 5; COMPND 18 MOLECULE: VRC03 LIGHT CHAIN; COMPND 19 CHAIN: R, r, 6; COMPND 20 ENGINEERED: YES; COMPND 21 MOL_ID: 6; COMPND 22 MOLECULE: VRC03 HEAVY CHAIN; COMPND 23 CHAIN: Q, q, 5; COMPND 24 ENGINEERED: YES; COMPND 25 MOL_ID: 7; COMPND 26 MOLECULE: GLYCOPROTEIN 41; COMPND 27 CHAIN: D, d, 1; COMPND 28 ENGINEERED: YES; COMPND 29 MOL_ID: 8; COMPND 30 MOLECULE: GLYCOPROTEIN 120; COMPND 31 CHAIN: C, c, 2; COMPND 32 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 29 MOL_ID: 5; SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 31 ORGANISM_COMMON: HUMAN; SOURCE 32 ORGANISM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 34 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 35 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 36 MOL_ID: 6; SOURCE 37 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 38 ORGANISM_COMMON: HUMAN; SOURCE 39 ORGANISM_TAXID: 9606; SOURCE 40 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 41 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 42 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 43 MOL_ID: 7; SOURCE 44 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 45 ORGANISM_TAXID: 11676; SOURCE 46 GENE: ENV; SOURCE 47 EXPRESSION_SYSTEM: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 48 EXPRESSION_SYSTEM_TAXID: 11676; SOURCE 49 MOL_ID: 8; SOURCE 50 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 51 ORGANISM_TAXID: 11676; SOURCE 52 GENE: ENV; SOURCE 53 EXPRESSION_SYSTEM: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 54 EXPRESSION_SYSTEM_TAXID: 11676 KEYWDS HIV-1 ENV, BG505 SOSIP, FUSION PEPTIDE, VRC03, PGT122, VFP20.01, KEYWDS 2 VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR P.ACHARYA,K.XU,K.LIU,B.CARRAGHER,C.S.POTTER,P.D.KWONG REVDAT 1 16-MAY-18 6CDE 0 JRNL AUTH K.XU,P.ACHARYA,B.CARRAGHER,C.S.POTTER,P.D.KWONG JRNL TITL EPITOPE-BASED VACCINE DESIGN YIELDS FUSION PEPTIDE-DIRECTED JRNL TITL 2 ANTIBODIES THAT NEUTRALIZE DIVERSE STRAINS OF HIV-1 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : APPION, GCTF, UCSF CHIMERA, PHENIX, REMARK 3 CRYOSPARC, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : CORRELATION COEFFICIENT REMARK 3 OVERALL ANISOTROPIC B VALUE : 107.000 REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.800 REMARK 3 NUMBER OF PARTICLES : 48248 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 6CDE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-FEB-18. REMARK 100 THE DEPOSITION ID IS D_1000232575. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : VFP20.01-BG505 DS-SOSIP-VRC03 REMARK 245 -PGT122; PGT122; VRC03; REMARK 245 GLYCOPROTEIN; VFP20.01 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 723 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : NULL REMARK 245 MAXIMUM DEFOCUS (NM) : NULL REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 70.70 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : 130000 REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: h, l, M, N, R, Q, D, C, H, L, REMARK 350 AND CHAINS: m, n, r, q, d, c, 7, 8, 6, REMARK 350 AND CHAINS: 5, 1, 2, 3, 4 REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLN h 1 REMARK 465 VAL h 2 REMARK 465 GLN h 3 REMARK 465 SER h 112 REMARK 465 PRO h 113 REMARK 465 ALA h 114 REMARK 465 SER h 115 REMARK 465 THR h 116 REMARK 465 LYS h 117 REMARK 465 GLY h 118 REMARK 465 PRO h 119 REMARK 465 SER h 120 REMARK 465 VAL h 121 REMARK 465 PHE h 122 REMARK 465 PRO h 123 REMARK 465 LEU h 124 REMARK 465 ALA h 125 REMARK 465 PRO h 126 REMARK 465 GLY h 127 REMARK 465 THR h 128 REMARK 465 ALA h 129 REMARK 465 ALA h 130 REMARK 465 LEU h 131 REMARK 465 GLY h 132 REMARK 465 CYS h 133 REMARK 465 LEU h 134 REMARK 465 VAL h 135 REMARK 465 LYS h 136 REMARK 465 ASP h 137 REMARK 465 TYR h 138 REMARK 465 PHE h 139 REMARK 465 PRO h 140 REMARK 465 GLU h 141 REMARK 465 PRO h 142 REMARK 465 VAL h 143 REMARK 465 THR h 144 REMARK 465 VAL h 145 REMARK 465 SER h 146 REMARK 465 TRP h 147 REMARK 465 ASN h 148 REMARK 465 SER h 149 REMARK 465 GLY h 150 REMARK 465 ALA h 151 REMARK 465 LEU h 152 REMARK 465 THR h 153 REMARK 465 SER h 154 REMARK 465 GLY h 155 REMARK 465 VAL h 156 REMARK 465 HIS h 157 REMARK 465 THR h 158 REMARK 465 PHE h 159 REMARK 465 PRO h 160 REMARK 465 ALA h 161 REMARK 465 VAL h 162 REMARK 465 LEU h 163 REMARK 465 GLN h 164 REMARK 465 SER h 165 REMARK 465 SER h 166 REMARK 465 GLY h 167 REMARK 465 LEU h 168 REMARK 465 TYR h 169 REMARK 465 SER h 170 REMARK 465 LEU h 171 REMARK 465 SER h 172 REMARK 465 SER h 173 REMARK 465 VAL h 174 REMARK 465 VAL h 175 REMARK 465 THR h 176 REMARK 465 VAL h 177 REMARK 465 PRO h 178 REMARK 465 SER h 179 REMARK 465 SER h 180 REMARK 465 SER h 181 REMARK 465 LEU h 182 REMARK 465 GLY h 183 REMARK 465 THR h 184 REMARK 465 GLN h 185 REMARK 465 THR h 186 REMARK 465 TYR h 187 REMARK 465 ILE h 188 REMARK 465 CYS h 189 REMARK 465 ASN h 190 REMARK 465 VAL h 191 REMARK 465 ASN h 192 REMARK 465 HIS h 193 REMARK 465 LYS h 194 REMARK 465 PRO h 195 REMARK 465 SER h 196 REMARK 465 ASN h 197 REMARK 465 THR h 198 REMARK 465 LYS h 199 REMARK 465 VAL h 200 REMARK 465 ASP h 201 REMARK 465 LYS h 202 REMARK 465 LYS h 203 REMARK 465 ALA h 204 REMARK 465 GLU h 205 REMARK 465 PRO h 206 REMARK 465 THR l 109 REMARK 465 VAL l 110 REMARK 465 ALA l 111 REMARK 465 ALA l 112 REMARK 465 PRO l 113 REMARK 465 SER l 114 REMARK 465 VAL l 115 REMARK 465 PHE l 116 REMARK 465 ILE l 117 REMARK 465 PHE l 118 REMARK 465 PRO l 119 REMARK 465 PRO l 120 REMARK 465 SER l 121 REMARK 465 ASP l 122 REMARK 465 GLU l 123 REMARK 465 GLN l 124 REMARK 465 LEU l 125 REMARK 465 LYS l 126 REMARK 465 SER l 127 REMARK 465 GLY l 128 REMARK 465 THR l 129 REMARK 465 ALA l 130 REMARK 465 SER l 131 REMARK 465 VAL l 132 REMARK 465 VAL l 133 REMARK 465 CYS l 134 REMARK 465 LEU l 135 REMARK 465 LEU l 136 REMARK 465 ASN l 137 REMARK 465 ASN l 138 REMARK 465 PHE l 139 REMARK 465 TYR l 140 REMARK 465 PRO l 141 REMARK 465 ARG l 142 REMARK 465 GLU l 143 REMARK 465 ALA l 144 REMARK 465 LYS l 145 REMARK 465 VAL l 146 REMARK 465 GLN l 147 REMARK 465 TRP l 148 REMARK 465 LYS l 149 REMARK 465 VAL l 150 REMARK 465 ASP l 151 REMARK 465 ASN l 152 REMARK 465 ALA l 153 REMARK 465 LEU l 154 REMARK 465 GLN l 155 REMARK 465 SER l 156 REMARK 465 GLY l 157 REMARK 465 ASN l 158 REMARK 465 SER l 159 REMARK 465 GLN l 160 REMARK 465 GLU l 161 REMARK 465 SER l 162 REMARK 465 VAL l 163 REMARK 465 THR l 164 REMARK 465 GLU l 165 REMARK 465 GLN l 166 REMARK 465 ASP l 167 REMARK 465 SER l 168 REMARK 465 LYS l 169 REMARK 465 ASP l 170 REMARK 465 SER l 171 REMARK 465 THR l 172 REMARK 465 TYR l 173 REMARK 465 SER l 174 REMARK 465 LEU l 175 REMARK 465 SER l 176 REMARK 465 SER l 177 REMARK 465 THR l 178 REMARK 465 LEU l 179 REMARK 465 THR l 180 REMARK 465 LEU l 181 REMARK 465 SER l 182 REMARK 465 LYS l 183 REMARK 465 ALA l 184 REMARK 465 ASP l 185 REMARK 465 TYR l 186 REMARK 465 GLU l 187 REMARK 465 LYS l 188 REMARK 465 HIS l 189 REMARK 465 LYS l 190 REMARK 465 VAL l 191 REMARK 465 TYR l 192 REMARK 465 ALA l 193 REMARK 465 CYS l 194 REMARK 465 GLU l 195 REMARK 465 VAL l 196 REMARK 465 THR l 197 REMARK 465 HIS l 198 REMARK 465 GLN l 199 REMARK 465 GLY l 200 REMARK 465 LEU l 201 REMARK 465 SER l 202 REMARK 465 SER l 203 REMARK 465 PRO l 204 REMARK 465 VAL l 205 REMARK 465 THR l 206 REMARK 465 LYS l 207 REMARK 465 SER l 208 REMARK 465 PHE l 209 REMARK 465 ASN l 210 REMARK 465 ARG l 211 REMARK 465 ALA M 133 REMARK 465 SER M 134 REMARK 465 THR M 135 REMARK 465 LYS M 136 REMARK 465 GLY M 137 REMARK 465 PRO M 138 REMARK 465 SER M 139 REMARK 465 VAL M 140 REMARK 465 PHE M 141 REMARK 465 PRO M 142 REMARK 465 LEU M 143 REMARK 465 ALA M 144 REMARK 465 PRO M 145 REMARK 465 SER M 146 REMARK 465 SER M 147 REMARK 465 GLY M 148 REMARK 465 GLY M 149 REMARK 465 THR M 150 REMARK 465 ALA M 151 REMARK 465 ALA M 152 REMARK 465 LEU M 153 REMARK 465 GLY M 154 REMARK 465 CYS M 155 REMARK 465 LEU M 156 REMARK 465 VAL M 157 REMARK 465 LYS M 158 REMARK 465 ASP M 159 REMARK 465 TYR M 160 REMARK 465 PHE M 161 REMARK 465 PRO M 162 REMARK 465 GLU M 163 REMARK 465 PRO M 164 REMARK 465 VAL M 165 REMARK 465 THR M 166 REMARK 465 VAL M 167 REMARK 465 SER M 168 REMARK 465 TRP M 169 REMARK 465 ASN M 170 REMARK 465 SER M 171 REMARK 465 GLY M 172 REMARK 465 ALA M 173 REMARK 465 LEU M 174 REMARK 465 THR M 175 REMARK 465 SER M 176 REMARK 465 GLY M 177 REMARK 465 VAL M 178 REMARK 465 HIS M 179 REMARK 465 THR M 180 REMARK 465 PHE M 181 REMARK 465 PRO M 182 REMARK 465 ALA M 183 REMARK 465 VAL M 184 REMARK 465 LEU M 185 REMARK 465 GLN M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 GLY M 189 REMARK 465 LEU M 190 REMARK 465 TYR M 191 REMARK 465 SER M 192 REMARK 465 LEU M 193 REMARK 465 SER M 194 REMARK 465 SER M 195 REMARK 465 VAL M 196 REMARK 465 VAL M 197 REMARK 465 THR M 198 REMARK 465 VAL M 199 REMARK 465 PRO M 200 REMARK 465 SER M 201 REMARK 465 SER M 202 REMARK 465 SER M 203 REMARK 465 LEU M 204 REMARK 465 GLY M 205 REMARK 465 THR M 206 REMARK 465 GLN M 207 REMARK 465 THR M 208 REMARK 465 TYR M 209 REMARK 465 ILE M 210 REMARK 465 CYS M 211 REMARK 465 ASN M 212 REMARK 465 VAL M 213 REMARK 465 ASN M 214 REMARK 465 HIS M 215 REMARK 465 LYS M 216 REMARK 465 PRO M 217 REMARK 465 SER M 218 REMARK 465 ASN M 219 REMARK 465 THR M 220 REMARK 465 LYS M 221 REMARK 465 VAL M 222 REMARK 465 ASP M 223 REMARK 465 LYS M 224 REMARK 465 ARG M 225 REMARK 465 VAL M 226 REMARK 465 GLU M 227 REMARK 465 PRO M 228 REMARK 465 PRO N 110 REMARK 465 LYS N 111 REMARK 465 ALA N 112 REMARK 465 ALA N 113 REMARK 465 PRO N 114 REMARK 465 SER N 115 REMARK 465 VAL N 116 REMARK 465 THR N 117 REMARK 465 LEU N 118 REMARK 465 PHE N 119 REMARK 465 PRO N 120 REMARK 465 PRO N 121 REMARK 465 SER N 122 REMARK 465 SER N 123 REMARK 465 GLU N 124 REMARK 465 GLU N 125 REMARK 465 LEU N 126 REMARK 465 GLN N 127 REMARK 465 ALA N 128 REMARK 465 ASN N 129 REMARK 465 LYS N 130 REMARK 465 ALA N 131 REMARK 465 THR N 132 REMARK 465 LEU N 133 REMARK 465 VAL N 134 REMARK 465 CYS N 135 REMARK 465 LEU N 136 REMARK 465 ILE N 137 REMARK 465 SER N 138 REMARK 465 ASP N 139 REMARK 465 PHE N 140 REMARK 465 TYR N 141 REMARK 465 PRO N 142 REMARK 465 GLY N 143 REMARK 465 ALA N 144 REMARK 465 VAL N 145 REMARK 465 THR N 146 REMARK 465 VAL N 147 REMARK 465 ALA N 148 REMARK 465 TRP N 149 REMARK 465 LYS N 150 REMARK 465 ALA N 151 REMARK 465 ASP N 152 REMARK 465 SER N 153 REMARK 465 SER N 154 REMARK 465 PRO N 155 REMARK 465 VAL N 156 REMARK 465 LYS N 157 REMARK 465 ALA N 158 REMARK 465 GLY N 159 REMARK 465 VAL N 160 REMARK 465 GLU N 161 REMARK 465 THR N 162 REMARK 465 THR N 163 REMARK 465 THR N 164 REMARK 465 PRO N 165 REMARK 465 SER N 166 REMARK 465 LYS N 167 REMARK 465 GLN N 168 REMARK 465 SER N 169 REMARK 465 ASN N 170 REMARK 465 ASN N 171 REMARK 465 LYS N 172 REMARK 465 TYR N 173 REMARK 465 ALA N 174 REMARK 465 ALA N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 TYR N 178 REMARK 465 LEU N 179 REMARK 465 SER N 180 REMARK 465 LEU N 181 REMARK 465 THR N 182 REMARK 465 PRO N 183 REMARK 465 GLU N 184 REMARK 465 GLN N 185 REMARK 465 TRP N 186 REMARK 465 LYS N 187 REMARK 465 SER N 188 REMARK 465 HIS N 189 REMARK 465 LYS N 190 REMARK 465 SER N 191 REMARK 465 TYR N 192 REMARK 465 SER N 193 REMARK 465 CYS N 194 REMARK 465 GLN N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLU N 199 REMARK 465 GLY N 200 REMARK 465 SER N 201 REMARK 465 THR N 202 REMARK 465 VAL N 203 REMARK 465 GLU N 204 REMARK 465 LYS N 205 REMARK 465 THR N 206 REMARK 465 VAL N 207 REMARK 465 ALA N 208 REMARK 465 PRO N 209 REMARK 465 THR N 210 REMARK 465 THR R 104 REMARK 465 VAL R 105 REMARK 465 ALA R 106 REMARK 465 ALA R 107 REMARK 465 PRO R 108 REMARK 465 SER R 109 REMARK 465 VAL R 110 REMARK 465 PHE R 111 REMARK 465 ILE R 112 REMARK 465 PHE R 113 REMARK 465 PRO R 114 REMARK 465 PRO R 115 REMARK 465 SER R 116 REMARK 465 ASP R 117 REMARK 465 GLU R 118 REMARK 465 GLN R 119 REMARK 465 LEU R 120 REMARK 465 LYS R 121 REMARK 465 SER R 122 REMARK 465 GLY R 123 REMARK 465 THR R 124 REMARK 465 ALA R 125 REMARK 465 SER R 126 REMARK 465 VAL R 127 REMARK 465 VAL R 128 REMARK 465 CYS R 129 REMARK 465 LEU R 130 REMARK 465 LEU R 131 REMARK 465 ASN R 132 REMARK 465 ASN R 133 REMARK 465 PHE R 134 REMARK 465 TYR R 135 REMARK 465 PRO R 136 REMARK 465 ARG R 137 REMARK 465 GLU R 138 REMARK 465 ALA R 139 REMARK 465 LYS R 140 REMARK 465 VAL R 141 REMARK 465 GLN R 142 REMARK 465 TRP R 143 REMARK 465 LYS R 144 REMARK 465 VAL R 145 REMARK 465 ASP R 146 REMARK 465 ASN R 147 REMARK 465 ALA R 148 REMARK 465 LEU R 149 REMARK 465 GLN R 150 REMARK 465 SER R 151 REMARK 465 GLY R 152 REMARK 465 ASN R 153 REMARK 465 SER R 154 REMARK 465 GLN R 155 REMARK 465 GLU R 156 REMARK 465 SER R 157 REMARK 465 VAL R 158 REMARK 465 THR R 159 REMARK 465 GLU R 160 REMARK 465 GLN R 161 REMARK 465 ASP R 162 REMARK 465 SER R 163 REMARK 465 LYS R 164 REMARK 465 ASP R 165 REMARK 465 SER R 166 REMARK 465 THR R 167 REMARK 465 TYR R 168 REMARK 465 SER R 169 REMARK 465 LEU R 170 REMARK 465 SER R 171 REMARK 465 SER R 172 REMARK 465 THR R 173 REMARK 465 LEU R 174 REMARK 465 THR R 175 REMARK 465 LEU R 176 REMARK 465 SER R 177 REMARK 465 LYS R 178 REMARK 465 ALA R 179 REMARK 465 ASP R 180 REMARK 465 TYR R 181 REMARK 465 GLU R 182 REMARK 465 LYS R 183 REMARK 465 HIS R 184 REMARK 465 LYS R 185 REMARK 465 VAL R 186 REMARK 465 TYR R 187 REMARK 465 ALA R 188 REMARK 465 CYS R 189 REMARK 465 GLU R 190 REMARK 465 VAL R 191 REMARK 465 THR R 192 REMARK 465 HIS R 193 REMARK 465 GLN R 194 REMARK 465 GLY R 195 REMARK 465 LEU R 196 REMARK 465 SER R 197 REMARK 465 SER R 198 REMARK 465 PRO R 199 REMARK 465 VAL R 200 REMARK 465 THR R 201 REMARK 465 LYS R 202 REMARK 465 SER R 203 REMARK 465 PHE R 204 REMARK 465 ASN R 205 REMARK 465 ARG R 206 REMARK 465 GLY R 207 REMARK 465 GLU R 208 REMARK 465 SER Q 112 REMARK 465 SER Q 113 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 GLY Q 129 REMARK 465 GLY Q 130 REMARK 465 THR Q 131 REMARK 465 ALA Q 132 REMARK 465 ALA Q 133 REMARK 465 LEU Q 134 REMARK 465 GLY Q 135 REMARK 465 CYS Q 136 REMARK 465 LEU Q 137 REMARK 465 VAL Q 138 REMARK 465 LYS Q 139 REMARK 465 ASP Q 140 REMARK 465 TYR Q 141 REMARK 465 PHE Q 142 REMARK 465 PRO Q 143 REMARK 465 GLU Q 144 REMARK 465 PRO Q 145 REMARK 465 VAL Q 146 REMARK 465 THR Q 147 REMARK 465 VAL Q 148 REMARK 465 SER Q 149 REMARK 465 TRP Q 150 REMARK 465 ASN Q 151 REMARK 465 SER Q 152 REMARK 465 GLY Q 153 REMARK 465 ALA Q 154 REMARK 465 LEU Q 155 REMARK 465 THR Q 156 REMARK 465 SER Q 157 REMARK 465 GLY Q 158 REMARK 465 VAL Q 159 REMARK 465 HIS Q 160 REMARK 465 THR Q 161 REMARK 465 PHE Q 162 REMARK 465 PRO Q 163 REMARK 465 ALA Q 164 REMARK 465 VAL Q 165 REMARK 465 LEU Q 166 REMARK 465 GLN Q 167 REMARK 465 SER Q 168 REMARK 465 SER Q 169 REMARK 465 GLY Q 170 REMARK 465 LEU Q 171 REMARK 465 TYR Q 172 REMARK 465 SER Q 173 REMARK 465 LEU Q 174 REMARK 465 SER Q 175 REMARK 465 SER Q 176 REMARK 465 VAL Q 177 REMARK 465 VAL Q 178 REMARK 465 THR Q 179 REMARK 465 VAL Q 180 REMARK 465 PRO Q 181 REMARK 465 SER Q 182 REMARK 465 SER Q 183 REMARK 465 SER Q 184 REMARK 465 LEU Q 185 REMARK 465 GLY Q 186 REMARK 465 THR Q 187 REMARK 465 GLN Q 188 REMARK 465 THR Q 189 REMARK 465 TYR Q 190 REMARK 465 ILE Q 191 REMARK 465 CYS Q 192 REMARK 465 ASN Q 193 REMARK 465 VAL Q 194 REMARK 465 ASN Q 195 REMARK 465 HIS Q 196 REMARK 465 LYS Q 197 REMARK 465 PRO Q 198 REMARK 465 SER Q 199 REMARK 465 ASN Q 200 REMARK 465 THR Q 201 REMARK 465 LYS Q 202 REMARK 465 VAL Q 203 REMARK 465 ASP Q 204 REMARK 465 LYS Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 GLU Q 208 REMARK 465 PRO Q 209 REMARK 465 LYS Q 210 REMARK 465 ILE D 548 REMARK 465 VAL D 549 REMARK 465 GLN D 550 REMARK 465 GLN D 551 REMARK 465 GLN D 552 REMARK 465 SER D 553 REMARK 465 ASN D 554 REMARK 465 LEU D 555 REMARK 465 LEU D 556 REMARK 465 ARG D 557 REMARK 465 ALA D 558 REMARK 465 ILE D 559 REMARK 465 GLU D 560 REMARK 465 ALA D 561 REMARK 465 GLN D 562 REMARK 465 GLN D 563 REMARK 465 HIS D 564 REMARK 465 LEU D 565 REMARK 465 LEU D 566 REMARK 465 LYS D 567 REMARK 465 LEU D 568 REMARK 465 ASP C 149 REMARK 465 GLU C 185A REMARK 465 ASN C 185B REMARK 465 GLN C 185C REMARK 465 GLY C 185D REMARK 465 ASN C 185E REMARK 465 ARG C 185F REMARK 465 SER C 185G REMARK 465 ASN C 185H REMARK 465 ASN C 185I REMARK 465 THR C 400 REMARK 465 SER C 401 REMARK 465 VAL C 402 REMARK 465 GLN C 403 REMARK 465 GLY C 404 REMARK 465 SER C 405 REMARK 465 ASN C 406 REMARK 465 SER C 407 REMARK 465 THR C 408 REMARK 465 GLY C 409 REMARK 465 SER C 410 REMARK 465 GLN H 1 REMARK 465 VAL H 2 REMARK 465 GLN H 3 REMARK 465 SER H 112 REMARK 465 PRO H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 GLY H 127 REMARK 465 THR H 128 REMARK 465 ALA H 129 REMARK 465 ALA H 130 REMARK 465 LEU H 131 REMARK 465 GLY H 132 REMARK 465 CYS H 133 REMARK 465 LEU H 134 REMARK 465 VAL H 135 REMARK 465 LYS H 136 REMARK 465 ASP H 137 REMARK 465 TYR H 138 REMARK 465 PHE H 139 REMARK 465 PRO H 140 REMARK 465 GLU H 141 REMARK 465 PRO H 142 REMARK 465 VAL H 143 REMARK 465 THR H 144 REMARK 465 VAL H 145 REMARK 465 SER H 146 REMARK 465 TRP H 147 REMARK 465 ASN H 148 REMARK 465 SER H 149 REMARK 465 GLY H 150 REMARK 465 ALA H 151 REMARK 465 LEU H 152 REMARK 465 THR H 153 REMARK 465 SER H 154 REMARK 465 GLY H 155 REMARK 465 VAL H 156 REMARK 465 HIS H 157 REMARK 465 THR H 158 REMARK 465 PHE H 159 REMARK 465 PRO H 160 REMARK 465 ALA H 161 REMARK 465 VAL H 162 REMARK 465 LEU H 163 REMARK 465 GLN H 164 REMARK 465 SER H 165 REMARK 465 SER H 166 REMARK 465 GLY H 167 REMARK 465 LEU H 168 REMARK 465 TYR H 169 REMARK 465 SER H 170 REMARK 465 LEU H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 VAL H 174 REMARK 465 VAL H 175 REMARK 465 THR H 176 REMARK 465 VAL H 177 REMARK 465 PRO H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 SER H 181 REMARK 465 LEU H 182 REMARK 465 GLY H 183 REMARK 465 THR H 184 REMARK 465 GLN H 185 REMARK 465 THR H 186 REMARK 465 TYR H 187 REMARK 465 ILE H 188 REMARK 465 CYS H 189 REMARK 465 ASN H 190 REMARK 465 VAL H 191 REMARK 465 ASN H 192 REMARK 465 HIS H 193 REMARK 465 LYS H 194 REMARK 465 PRO H 195 REMARK 465 SER H 196 REMARK 465 ASN H 197 REMARK 465 THR H 198 REMARK 465 LYS H 199 REMARK 465 VAL H 200 REMARK 465 ASP H 201 REMARK 465 LYS H 202 REMARK 465 LYS H 203 REMARK 465 ALA H 204 REMARK 465 GLU H 205 REMARK 465 PRO H 206 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 ALA m 133 REMARK 465 SER m 134 REMARK 465 THR m 135 REMARK 465 LYS m 136 REMARK 465 GLY m 137 REMARK 465 PRO m 138 REMARK 465 SER m 139 REMARK 465 VAL m 140 REMARK 465 PHE m 141 REMARK 465 PRO m 142 REMARK 465 LEU m 143 REMARK 465 ALA m 144 REMARK 465 PRO m 145 REMARK 465 SER m 146 REMARK 465 SER m 147 REMARK 465 GLY m 148 REMARK 465 GLY m 149 REMARK 465 THR m 150 REMARK 465 ALA m 151 REMARK 465 ALA m 152 REMARK 465 LEU m 153 REMARK 465 GLY m 154 REMARK 465 CYS m 155 REMARK 465 LEU m 156 REMARK 465 VAL m 157 REMARK 465 LYS m 158 REMARK 465 ASP m 159 REMARK 465 TYR m 160 REMARK 465 PHE m 161 REMARK 465 PRO m 162 REMARK 465 GLU m 163 REMARK 465 PRO m 164 REMARK 465 VAL m 165 REMARK 465 THR m 166 REMARK 465 VAL m 167 REMARK 465 SER m 168 REMARK 465 TRP m 169 REMARK 465 ASN m 170 REMARK 465 SER m 171 REMARK 465 GLY m 172 REMARK 465 ALA m 173 REMARK 465 LEU m 174 REMARK 465 THR m 175 REMARK 465 SER m 176 REMARK 465 GLY m 177 REMARK 465 VAL m 178 REMARK 465 HIS m 179 REMARK 465 THR m 180 REMARK 465 PHE m 181 REMARK 465 PRO m 182 REMARK 465 ALA m 183 REMARK 465 VAL m 184 REMARK 465 LEU m 185 REMARK 465 GLN m 186 REMARK 465 SER m 187 REMARK 465 SER m 188 REMARK 465 GLY m 189 REMARK 465 LEU m 190 REMARK 465 TYR m 191 REMARK 465 SER m 192 REMARK 465 LEU m 193 REMARK 465 SER m 194 REMARK 465 SER m 195 REMARK 465 VAL m 196 REMARK 465 VAL m 197 REMARK 465 THR m 198 REMARK 465 VAL m 199 REMARK 465 PRO m 200 REMARK 465 SER m 201 REMARK 465 SER m 202 REMARK 465 SER m 203 REMARK 465 LEU m 204 REMARK 465 GLY m 205 REMARK 465 THR m 206 REMARK 465 GLN m 207 REMARK 465 THR m 208 REMARK 465 TYR m 209 REMARK 465 ILE m 210 REMARK 465 CYS m 211 REMARK 465 ASN m 212 REMARK 465 VAL m 213 REMARK 465 ASN m 214 REMARK 465 HIS m 215 REMARK 465 LYS m 216 REMARK 465 PRO m 217 REMARK 465 SER m 218 REMARK 465 ASN m 219 REMARK 465 THR m 220 REMARK 465 LYS m 221 REMARK 465 VAL m 222 REMARK 465 ASP m 223 REMARK 465 LYS m 224 REMARK 465 ARG m 225 REMARK 465 VAL m 226 REMARK 465 GLU m 227 REMARK 465 PRO m 228 REMARK 465 PRO n 110 REMARK 465 LYS n 111 REMARK 465 ALA n 112 REMARK 465 ALA n 113 REMARK 465 PRO n 114 REMARK 465 SER n 115 REMARK 465 VAL n 116 REMARK 465 THR n 117 REMARK 465 LEU n 118 REMARK 465 PHE n 119 REMARK 465 PRO n 120 REMARK 465 PRO n 121 REMARK 465 SER n 122 REMARK 465 SER n 123 REMARK 465 GLU n 124 REMARK 465 GLU n 125 REMARK 465 LEU n 126 REMARK 465 GLN n 127 REMARK 465 ALA n 128 REMARK 465 ASN n 129 REMARK 465 LYS n 130 REMARK 465 ALA n 131 REMARK 465 THR n 132 REMARK 465 LEU n 133 REMARK 465 VAL n 134 REMARK 465 CYS n 135 REMARK 465 LEU n 136 REMARK 465 ILE n 137 REMARK 465 SER n 138 REMARK 465 ASP n 139 REMARK 465 PHE n 140 REMARK 465 TYR n 141 REMARK 465 PRO n 142 REMARK 465 GLY n 143 REMARK 465 ALA n 144 REMARK 465 VAL n 145 REMARK 465 THR n 146 REMARK 465 VAL n 147 REMARK 465 ALA n 148 REMARK 465 TRP n 149 REMARK 465 LYS n 150 REMARK 465 ALA n 151 REMARK 465 ASP n 152 REMARK 465 SER n 153 REMARK 465 SER n 154 REMARK 465 PRO n 155 REMARK 465 VAL n 156 REMARK 465 LYS n 157 REMARK 465 ALA n 158 REMARK 465 GLY n 159 REMARK 465 VAL n 160 REMARK 465 GLU n 161 REMARK 465 THR n 162 REMARK 465 THR n 163 REMARK 465 THR n 164 REMARK 465 PRO n 165 REMARK 465 SER n 166 REMARK 465 LYS n 167 REMARK 465 GLN n 168 REMARK 465 SER n 169 REMARK 465 ASN n 170 REMARK 465 ASN n 171 REMARK 465 LYS n 172 REMARK 465 TYR n 173 REMARK 465 ALA n 174 REMARK 465 ALA n 175 REMARK 465 SER n 176 REMARK 465 SER n 177 REMARK 465 TYR n 178 REMARK 465 LEU n 179 REMARK 465 SER n 180 REMARK 465 LEU n 181 REMARK 465 THR n 182 REMARK 465 PRO n 183 REMARK 465 GLU n 184 REMARK 465 GLN n 185 REMARK 465 TRP n 186 REMARK 465 LYS n 187 REMARK 465 SER n 188 REMARK 465 HIS n 189 REMARK 465 LYS n 190 REMARK 465 SER n 191 REMARK 465 TYR n 192 REMARK 465 SER n 193 REMARK 465 CYS n 194 REMARK 465 GLN n 195 REMARK 465 VAL n 196 REMARK 465 THR n 197 REMARK 465 HIS n 198 REMARK 465 GLU n 199 REMARK 465 GLY n 200 REMARK 465 SER n 201 REMARK 465 THR n 202 REMARK 465 VAL n 203 REMARK 465 GLU n 204 REMARK 465 LYS n 205 REMARK 465 THR n 206 REMARK 465 VAL n 207 REMARK 465 ALA n 208 REMARK 465 PRO n 209 REMARK 465 THR n 210 REMARK 465 THR r 104 REMARK 465 VAL r 105 REMARK 465 ALA r 106 REMARK 465 ALA r 107 REMARK 465 PRO r 108 REMARK 465 SER r 109 REMARK 465 VAL r 110 REMARK 465 PHE r 111 REMARK 465 ILE r 112 REMARK 465 PHE r 113 REMARK 465 PRO r 114 REMARK 465 PRO r 115 REMARK 465 SER r 116 REMARK 465 ASP r 117 REMARK 465 GLU r 118 REMARK 465 GLN r 119 REMARK 465 LEU r 120 REMARK 465 LYS r 121 REMARK 465 SER r 122 REMARK 465 GLY r 123 REMARK 465 THR r 124 REMARK 465 ALA r 125 REMARK 465 SER r 126 REMARK 465 VAL r 127 REMARK 465 VAL r 128 REMARK 465 CYS r 129 REMARK 465 LEU r 130 REMARK 465 LEU r 131 REMARK 465 ASN r 132 REMARK 465 ASN r 133 REMARK 465 PHE r 134 REMARK 465 TYR r 135 REMARK 465 PRO r 136 REMARK 465 ARG r 137 REMARK 465 GLU r 138 REMARK 465 ALA r 139 REMARK 465 LYS r 140 REMARK 465 VAL r 141 REMARK 465 GLN r 142 REMARK 465 TRP r 143 REMARK 465 LYS r 144 REMARK 465 VAL r 145 REMARK 465 ASP r 146 REMARK 465 ASN r 147 REMARK 465 ALA r 148 REMARK 465 LEU r 149 REMARK 465 GLN r 150 REMARK 465 SER r 151 REMARK 465 GLY r 152 REMARK 465 ASN r 153 REMARK 465 SER r 154 REMARK 465 GLN r 155 REMARK 465 GLU r 156 REMARK 465 SER r 157 REMARK 465 VAL r 158 REMARK 465 THR r 159 REMARK 465 GLU r 160 REMARK 465 GLN r 161 REMARK 465 ASP r 162 REMARK 465 SER r 163 REMARK 465 LYS r 164 REMARK 465 ASP r 165 REMARK 465 SER r 166 REMARK 465 THR r 167 REMARK 465 TYR r 168 REMARK 465 SER r 169 REMARK 465 LEU r 170 REMARK 465 SER r 171 REMARK 465 SER r 172 REMARK 465 THR r 173 REMARK 465 LEU r 174 REMARK 465 THR r 175 REMARK 465 LEU r 176 REMARK 465 SER r 177 REMARK 465 LYS r 178 REMARK 465 ALA r 179 REMARK 465 ASP r 180 REMARK 465 TYR r 181 REMARK 465 GLU r 182 REMARK 465 LYS r 183 REMARK 465 HIS r 184 REMARK 465 LYS r 185 REMARK 465 VAL r 186 REMARK 465 TYR r 187 REMARK 465 ALA r 188 REMARK 465 CYS r 189 REMARK 465 GLU r 190 REMARK 465 VAL r 191 REMARK 465 THR r 192 REMARK 465 HIS r 193 REMARK 465 GLN r 194 REMARK 465 GLY r 195 REMARK 465 LEU r 196 REMARK 465 SER r 197 REMARK 465 SER r 198 REMARK 465 PRO r 199 REMARK 465 VAL r 200 REMARK 465 THR r 201 REMARK 465 LYS r 202 REMARK 465 SER r 203 REMARK 465 PHE r 204 REMARK 465 ASN r 205 REMARK 465 ARG r 206 REMARK 465 GLY r 207 REMARK 465 GLU r 208 REMARK 465 SER q 112 REMARK 465 SER q 113 REMARK 465 ALA q 114 REMARK 465 SER q 115 REMARK 465 THR q 116 REMARK 465 LYS q 117 REMARK 465 GLY q 118 REMARK 465 PRO q 119 REMARK 465 SER q 120 REMARK 465 VAL q 121 REMARK 465 PHE q 122 REMARK 465 PRO q 123 REMARK 465 LEU q 124 REMARK 465 ALA q 125 REMARK 465 PRO q 126 REMARK 465 SER q 127 REMARK 465 SER q 128 REMARK 465 GLY q 129 REMARK 465 GLY q 130 REMARK 465 THR q 131 REMARK 465 ALA q 132 REMARK 465 ALA q 133 REMARK 465 LEU q 134 REMARK 465 GLY q 135 REMARK 465 CYS q 136 REMARK 465 LEU q 137 REMARK 465 VAL q 138 REMARK 465 LYS q 139 REMARK 465 ASP q 140 REMARK 465 TYR q 141 REMARK 465 PHE q 142 REMARK 465 PRO q 143 REMARK 465 GLU q 144 REMARK 465 PRO q 145 REMARK 465 VAL q 146 REMARK 465 THR q 147 REMARK 465 VAL q 148 REMARK 465 SER q 149 REMARK 465 TRP q 150 REMARK 465 ASN q 151 REMARK 465 SER q 152 REMARK 465 GLY q 153 REMARK 465 ALA q 154 REMARK 465 LEU q 155 REMARK 465 THR q 156 REMARK 465 SER q 157 REMARK 465 GLY q 158 REMARK 465 VAL q 159 REMARK 465 HIS q 160 REMARK 465 THR q 161 REMARK 465 PHE q 162 REMARK 465 PRO q 163 REMARK 465 ALA q 164 REMARK 465 VAL q 165 REMARK 465 LEU q 166 REMARK 465 GLN q 167 REMARK 465 SER q 168 REMARK 465 SER q 169 REMARK 465 GLY q 170 REMARK 465 LEU q 171 REMARK 465 TYR q 172 REMARK 465 SER q 173 REMARK 465 LEU q 174 REMARK 465 SER q 175 REMARK 465 SER q 176 REMARK 465 VAL q 177 REMARK 465 VAL q 178 REMARK 465 THR q 179 REMARK 465 VAL q 180 REMARK 465 PRO q 181 REMARK 465 SER q 182 REMARK 465 SER q 183 REMARK 465 SER q 184 REMARK 465 LEU q 185 REMARK 465 GLY q 186 REMARK 465 THR q 187 REMARK 465 GLN q 188 REMARK 465 THR q 189 REMARK 465 TYR q 190 REMARK 465 ILE q 191 REMARK 465 CYS q 192 REMARK 465 ASN q 193 REMARK 465 VAL q 194 REMARK 465 ASN q 195 REMARK 465 HIS q 196 REMARK 465 LYS q 197 REMARK 465 PRO q 198 REMARK 465 SER q 199 REMARK 465 ASN q 200 REMARK 465 THR q 201 REMARK 465 LYS q 202 REMARK 465 VAL q 203 REMARK 465 ASP q 204 REMARK 465 LYS q 205 REMARK 465 LYS q 206 REMARK 465 VAL q 207 REMARK 465 GLU q 208 REMARK 465 PRO q 209 REMARK 465 LYS q 210 REMARK 465 ILE d 548 REMARK 465 VAL d 549 REMARK 465 GLN d 550 REMARK 465 GLN d 551 REMARK 465 GLN d 552 REMARK 465 SER d 553 REMARK 465 ASN d 554 REMARK 465 LEU d 555 REMARK 465 LEU d 556 REMARK 465 ARG d 557 REMARK 465 ALA d 558 REMARK 465 ILE d 559 REMARK 465 GLU d 560 REMARK 465 ALA d 561 REMARK 465 GLN d 562 REMARK 465 GLN d 563 REMARK 465 HIS d 564 REMARK 465 LEU d 565 REMARK 465 LEU d 566 REMARK 465 LYS d 567 REMARK 465 LEU d 568 REMARK 465 ASP c 149 REMARK 465 GLU c 185A REMARK 465 ASN c 185B REMARK 465 GLN c 185C REMARK 465 GLY c 185D REMARK 465 ASN c 185E REMARK 465 ARG c 185F REMARK 465 SER c 185G REMARK 465 ASN c 185H REMARK 465 ASN c 185I REMARK 465 THR c 400 REMARK 465 SER c 401 REMARK 465 VAL c 402 REMARK 465 GLN c 403 REMARK 465 GLY c 404 REMARK 465 SER c 405 REMARK 465 ASN c 406 REMARK 465 SER c 407 REMARK 465 THR c 408 REMARK 465 GLY c 409 REMARK 465 SER c 410 REMARK 465 ALA 7 133 REMARK 465 SER 7 134 REMARK 465 THR 7 135 REMARK 465 LYS 7 136 REMARK 465 GLY 7 137 REMARK 465 PRO 7 138 REMARK 465 SER 7 139 REMARK 465 VAL 7 140 REMARK 465 PHE 7 141 REMARK 465 PRO 7 142 REMARK 465 LEU 7 143 REMARK 465 ALA 7 144 REMARK 465 PRO 7 145 REMARK 465 SER 7 146 REMARK 465 SER 7 147 REMARK 465 GLY 7 148 REMARK 465 GLY 7 149 REMARK 465 THR 7 150 REMARK 465 ALA 7 151 REMARK 465 ALA 7 152 REMARK 465 LEU 7 153 REMARK 465 GLY 7 154 REMARK 465 CYS 7 155 REMARK 465 LEU 7 156 REMARK 465 VAL 7 157 REMARK 465 LYS 7 158 REMARK 465 ASP 7 159 REMARK 465 TYR 7 160 REMARK 465 PHE 7 161 REMARK 465 PRO 7 162 REMARK 465 GLU 7 163 REMARK 465 PRO 7 164 REMARK 465 VAL 7 165 REMARK 465 THR 7 166 REMARK 465 VAL 7 167 REMARK 465 SER 7 168 REMARK 465 TRP 7 169 REMARK 465 ASN 7 170 REMARK 465 SER 7 171 REMARK 465 GLY 7 172 REMARK 465 ALA 7 173 REMARK 465 LEU 7 174 REMARK 465 THR 7 175 REMARK 465 SER 7 176 REMARK 465 GLY 7 177 REMARK 465 VAL 7 178 REMARK 465 HIS 7 179 REMARK 465 THR 7 180 REMARK 465 PHE 7 181 REMARK 465 PRO 7 182 REMARK 465 ALA 7 183 REMARK 465 VAL 7 184 REMARK 465 LEU 7 185 REMARK 465 GLN 7 186 REMARK 465 SER 7 187 REMARK 465 SER 7 188 REMARK 465 GLY 7 189 REMARK 465 LEU 7 190 REMARK 465 TYR 7 191 REMARK 465 SER 7 192 REMARK 465 LEU 7 193 REMARK 465 SER 7 194 REMARK 465 SER 7 195 REMARK 465 VAL 7 196 REMARK 465 VAL 7 197 REMARK 465 THR 7 198 REMARK 465 VAL 7 199 REMARK 465 PRO 7 200 REMARK 465 SER 7 201 REMARK 465 SER 7 202 REMARK 465 SER 7 203 REMARK 465 LEU 7 204 REMARK 465 GLY 7 205 REMARK 465 THR 7 206 REMARK 465 GLN 7 207 REMARK 465 THR 7 208 REMARK 465 TYR 7 209 REMARK 465 ILE 7 210 REMARK 465 CYS 7 211 REMARK 465 ASN 7 212 REMARK 465 VAL 7 213 REMARK 465 ASN 7 214 REMARK 465 HIS 7 215 REMARK 465 LYS 7 216 REMARK 465 PRO 7 217 REMARK 465 SER 7 218 REMARK 465 ASN 7 219 REMARK 465 THR 7 220 REMARK 465 LYS 7 221 REMARK 465 VAL 7 222 REMARK 465 ASP 7 223 REMARK 465 LYS 7 224 REMARK 465 ARG 7 225 REMARK 465 VAL 7 226 REMARK 465 GLU 7 227 REMARK 465 PRO 7 228 REMARK 465 PRO 8 110 REMARK 465 LYS 8 111 REMARK 465 ALA 8 112 REMARK 465 ALA 8 113 REMARK 465 PRO 8 114 REMARK 465 SER 8 115 REMARK 465 VAL 8 116 REMARK 465 THR 8 117 REMARK 465 LEU 8 118 REMARK 465 PHE 8 119 REMARK 465 PRO 8 120 REMARK 465 PRO 8 121 REMARK 465 SER 8 122 REMARK 465 SER 8 123 REMARK 465 GLU 8 124 REMARK 465 GLU 8 125 REMARK 465 LEU 8 126 REMARK 465 GLN 8 127 REMARK 465 ALA 8 128 REMARK 465 ASN 8 129 REMARK 465 LYS 8 130 REMARK 465 ALA 8 131 REMARK 465 THR 8 132 REMARK 465 LEU 8 133 REMARK 465 VAL 8 134 REMARK 465 CYS 8 135 REMARK 465 LEU 8 136 REMARK 465 ILE 8 137 REMARK 465 SER 8 138 REMARK 465 ASP 8 139 REMARK 465 PHE 8 140 REMARK 465 TYR 8 141 REMARK 465 PRO 8 142 REMARK 465 GLY 8 143 REMARK 465 ALA 8 144 REMARK 465 VAL 8 145 REMARK 465 THR 8 146 REMARK 465 VAL 8 147 REMARK 465 ALA 8 148 REMARK 465 TRP 8 149 REMARK 465 LYS 8 150 REMARK 465 ALA 8 151 REMARK 465 ASP 8 152 REMARK 465 SER 8 153 REMARK 465 SER 8 154 REMARK 465 PRO 8 155 REMARK 465 VAL 8 156 REMARK 465 LYS 8 157 REMARK 465 ALA 8 158 REMARK 465 GLY 8 159 REMARK 465 VAL 8 160 REMARK 465 GLU 8 161 REMARK 465 THR 8 162 REMARK 465 THR 8 163 REMARK 465 THR 8 164 REMARK 465 PRO 8 165 REMARK 465 SER 8 166 REMARK 465 LYS 8 167 REMARK 465 GLN 8 168 REMARK 465 SER 8 169 REMARK 465 ASN 8 170 REMARK 465 ASN 8 171 REMARK 465 LYS 8 172 REMARK 465 TYR 8 173 REMARK 465 ALA 8 174 REMARK 465 ALA 8 175 REMARK 465 SER 8 176 REMARK 465 SER 8 177 REMARK 465 TYR 8 178 REMARK 465 LEU 8 179 REMARK 465 SER 8 180 REMARK 465 LEU 8 181 REMARK 465 THR 8 182 REMARK 465 PRO 8 183 REMARK 465 GLU 8 184 REMARK 465 GLN 8 185 REMARK 465 TRP 8 186 REMARK 465 LYS 8 187 REMARK 465 SER 8 188 REMARK 465 HIS 8 189 REMARK 465 LYS 8 190 REMARK 465 SER 8 191 REMARK 465 TYR 8 192 REMARK 465 SER 8 193 REMARK 465 CYS 8 194 REMARK 465 GLN 8 195 REMARK 465 VAL 8 196 REMARK 465 THR 8 197 REMARK 465 HIS 8 198 REMARK 465 GLU 8 199 REMARK 465 GLY 8 200 REMARK 465 SER 8 201 REMARK 465 THR 8 202 REMARK 465 VAL 8 203 REMARK 465 GLU 8 204 REMARK 465 LYS 8 205 REMARK 465 THR 8 206 REMARK 465 VAL 8 207 REMARK 465 ALA 8 208 REMARK 465 PRO 8 209 REMARK 465 THR 8 210 REMARK 465 THR 6 104 REMARK 465 VAL 6 105 REMARK 465 ALA 6 106 REMARK 465 ALA 6 107 REMARK 465 PRO 6 108 REMARK 465 SER 6 109 REMARK 465 VAL 6 110 REMARK 465 PHE 6 111 REMARK 465 ILE 6 112 REMARK 465 PHE 6 113 REMARK 465 PRO 6 114 REMARK 465 PRO 6 115 REMARK 465 SER 6 116 REMARK 465 ASP 6 117 REMARK 465 GLU 6 118 REMARK 465 GLN 6 119 REMARK 465 LEU 6 120 REMARK 465 LYS 6 121 REMARK 465 SER 6 122 REMARK 465 GLY 6 123 REMARK 465 THR 6 124 REMARK 465 ALA 6 125 REMARK 465 SER 6 126 REMARK 465 VAL 6 127 REMARK 465 VAL 6 128 REMARK 465 CYS 6 129 REMARK 465 LEU 6 130 REMARK 465 LEU 6 131 REMARK 465 ASN 6 132 REMARK 465 ASN 6 133 REMARK 465 PHE 6 134 REMARK 465 TYR 6 135 REMARK 465 PRO 6 136 REMARK 465 ARG 6 137 REMARK 465 GLU 6 138 REMARK 465 ALA 6 139 REMARK 465 LYS 6 140 REMARK 465 VAL 6 141 REMARK 465 GLN 6 142 REMARK 465 TRP 6 143 REMARK 465 LYS 6 144 REMARK 465 VAL 6 145 REMARK 465 ASP 6 146 REMARK 465 ASN 6 147 REMARK 465 ALA 6 148 REMARK 465 LEU 6 149 REMARK 465 GLN 6 150 REMARK 465 SER 6 151 REMARK 465 GLY 6 152 REMARK 465 ASN 6 153 REMARK 465 SER 6 154 REMARK 465 GLN 6 155 REMARK 465 GLU 6 156 REMARK 465 SER 6 157 REMARK 465 VAL 6 158 REMARK 465 THR 6 159 REMARK 465 GLU 6 160 REMARK 465 GLN 6 161 REMARK 465 ASP 6 162 REMARK 465 SER 6 163 REMARK 465 LYS 6 164 REMARK 465 ASP 6 165 REMARK 465 SER 6 166 REMARK 465 THR 6 167 REMARK 465 TYR 6 168 REMARK 465 SER 6 169 REMARK 465 LEU 6 170 REMARK 465 SER 6 171 REMARK 465 SER 6 172 REMARK 465 THR 6 173 REMARK 465 LEU 6 174 REMARK 465 THR 6 175 REMARK 465 LEU 6 176 REMARK 465 SER 6 177 REMARK 465 LYS 6 178 REMARK 465 ALA 6 179 REMARK 465 ASP 6 180 REMARK 465 TYR 6 181 REMARK 465 GLU 6 182 REMARK 465 LYS 6 183 REMARK 465 HIS 6 184 REMARK 465 LYS 6 185 REMARK 465 VAL 6 186 REMARK 465 TYR 6 187 REMARK 465 ALA 6 188 REMARK 465 CYS 6 189 REMARK 465 GLU 6 190 REMARK 465 VAL 6 191 REMARK 465 THR 6 192 REMARK 465 HIS 6 193 REMARK 465 GLN 6 194 REMARK 465 GLY 6 195 REMARK 465 LEU 6 196 REMARK 465 SER 6 197 REMARK 465 SER 6 198 REMARK 465 PRO 6 199 REMARK 465 VAL 6 200 REMARK 465 THR 6 201 REMARK 465 LYS 6 202 REMARK 465 SER 6 203 REMARK 465 PHE 6 204 REMARK 465 ASN 6 205 REMARK 465 ARG 6 206 REMARK 465 GLY 6 207 REMARK 465 GLU 6 208 REMARK 465 SER 5 112 REMARK 465 SER 5 113 REMARK 465 ALA 5 114 REMARK 465 SER 5 115 REMARK 465 THR 5 116 REMARK 465 LYS 5 117 REMARK 465 GLY 5 118 REMARK 465 PRO 5 119 REMARK 465 SER 5 120 REMARK 465 VAL 5 121 REMARK 465 PHE 5 122 REMARK 465 PRO 5 123 REMARK 465 LEU 5 124 REMARK 465 ALA 5 125 REMARK 465 PRO 5 126 REMARK 465 SER 5 127 REMARK 465 SER 5 128 REMARK 465 GLY 5 129 REMARK 465 GLY 5 130 REMARK 465 THR 5 131 REMARK 465 ALA 5 132 REMARK 465 ALA 5 133 REMARK 465 LEU 5 134 REMARK 465 GLY 5 135 REMARK 465 CYS 5 136 REMARK 465 LEU 5 137 REMARK 465 VAL 5 138 REMARK 465 LYS 5 139 REMARK 465 ASP 5 140 REMARK 465 TYR 5 141 REMARK 465 PHE 5 142 REMARK 465 PRO 5 143 REMARK 465 GLU 5 144 REMARK 465 PRO 5 145 REMARK 465 VAL 5 146 REMARK 465 THR 5 147 REMARK 465 VAL 5 148 REMARK 465 SER 5 149 REMARK 465 TRP 5 150 REMARK 465 ASN 5 151 REMARK 465 SER 5 152 REMARK 465 GLY 5 153 REMARK 465 ALA 5 154 REMARK 465 LEU 5 155 REMARK 465 THR 5 156 REMARK 465 SER 5 157 REMARK 465 GLY 5 158 REMARK 465 VAL 5 159 REMARK 465 HIS 5 160 REMARK 465 THR 5 161 REMARK 465 PHE 5 162 REMARK 465 PRO 5 163 REMARK 465 ALA 5 164 REMARK 465 VAL 5 165 REMARK 465 LEU 5 166 REMARK 465 GLN 5 167 REMARK 465 SER 5 168 REMARK 465 SER 5 169 REMARK 465 GLY 5 170 REMARK 465 LEU 5 171 REMARK 465 TYR 5 172 REMARK 465 SER 5 173 REMARK 465 LEU 5 174 REMARK 465 SER 5 175 REMARK 465 SER 5 176 REMARK 465 VAL 5 177 REMARK 465 VAL 5 178 REMARK 465 THR 5 179 REMARK 465 VAL 5 180 REMARK 465 PRO 5 181 REMARK 465 SER 5 182 REMARK 465 SER 5 183 REMARK 465 SER 5 184 REMARK 465 LEU 5 185 REMARK 465 GLY 5 186 REMARK 465 THR 5 187 REMARK 465 GLN 5 188 REMARK 465 THR 5 189 REMARK 465 TYR 5 190 REMARK 465 ILE 5 191 REMARK 465 CYS 5 192 REMARK 465 ASN 5 193 REMARK 465 VAL 5 194 REMARK 465 ASN 5 195 REMARK 465 HIS 5 196 REMARK 465 LYS 5 197 REMARK 465 PRO 5 198 REMARK 465 SER 5 199 REMARK 465 ASN 5 200 REMARK 465 THR 5 201 REMARK 465 LYS 5 202 REMARK 465 VAL 5 203 REMARK 465 ASP 5 204 REMARK 465 LYS 5 205 REMARK 465 LYS 5 206 REMARK 465 VAL 5 207 REMARK 465 GLU 5 208 REMARK 465 PRO 5 209 REMARK 465 LYS 5 210 REMARK 465 ILE 1 548 REMARK 465 VAL 1 549 REMARK 465 GLN 1 550 REMARK 465 GLN 1 551 REMARK 465 GLN 1 552 REMARK 465 SER 1 553 REMARK 465 ASN 1 554 REMARK 465 LEU 1 555 REMARK 465 LEU 1 556 REMARK 465 ARG 1 557 REMARK 465 ALA 1 558 REMARK 465 ILE 1 559 REMARK 465 GLU 1 560 REMARK 465 ALA 1 561 REMARK 465 GLN 1 562 REMARK 465 GLN 1 563 REMARK 465 HIS 1 564 REMARK 465 LEU 1 565 REMARK 465 LEU 1 566 REMARK 465 LYS 1 567 REMARK 465 LEU 1 568 REMARK 465 ASP 2 149 REMARK 465 GLU 2 185A REMARK 465 ASN 2 185B REMARK 465 GLN 2 185C REMARK 465 GLY 2 185D REMARK 465 ASN 2 185E REMARK 465 ARG 2 185F REMARK 465 SER 2 185G REMARK 465 ASN 2 185H REMARK 465 ASN 2 185I REMARK 465 THR 2 400 REMARK 465 SER 2 401 REMARK 465 VAL 2 402 REMARK 465 GLN 2 403 REMARK 465 GLY 2 404 REMARK 465 SER 2 405 REMARK 465 ASN 2 406 REMARK 465 SER 2 407 REMARK 465 THR 2 408 REMARK 465 GLY 2 409 REMARK 465 SER 2 410 REMARK 465 GLN 3 1 REMARK 465 VAL 3 2 REMARK 465 GLN 3 3 REMARK 465 SER 3 112 REMARK 465 PRO 3 113 REMARK 465 ALA 3 114 REMARK 465 SER 3 115 REMARK 465 THR 3 116 REMARK 465 LYS 3 117 REMARK 465 GLY 3 118 REMARK 465 PRO 3 119 REMARK 465 SER 3 120 REMARK 465 VAL 3 121 REMARK 465 PHE 3 122 REMARK 465 PRO 3 123 REMARK 465 LEU 3 124 REMARK 465 ALA 3 125 REMARK 465 PRO 3 126 REMARK 465 GLY 3 127 REMARK 465 THR 3 128 REMARK 465 ALA 3 129 REMARK 465 ALA 3 130 REMARK 465 LEU 3 131 REMARK 465 GLY 3 132 REMARK 465 CYS 3 133 REMARK 465 LEU 3 134 REMARK 465 VAL 3 135 REMARK 465 LYS 3 136 REMARK 465 ASP 3 137 REMARK 465 TYR 3 138 REMARK 465 PHE 3 139 REMARK 465 PRO 3 140 REMARK 465 GLU 3 141 REMARK 465 PRO 3 142 REMARK 465 VAL 3 143 REMARK 465 THR 3 144 REMARK 465 VAL 3 145 REMARK 465 SER 3 146 REMARK 465 TRP 3 147 REMARK 465 ASN 3 148 REMARK 465 SER 3 149 REMARK 465 GLY 3 150 REMARK 465 ALA 3 151 REMARK 465 LEU 3 152 REMARK 465 THR 3 153 REMARK 465 SER 3 154 REMARK 465 GLY 3 155 REMARK 465 VAL 3 156 REMARK 465 HIS 3 157 REMARK 465 THR 3 158 REMARK 465 PHE 3 159 REMARK 465 PRO 3 160 REMARK 465 ALA 3 161 REMARK 465 VAL 3 162 REMARK 465 LEU 3 163 REMARK 465 GLN 3 164 REMARK 465 SER 3 165 REMARK 465 SER 3 166 REMARK 465 GLY 3 167 REMARK 465 LEU 3 168 REMARK 465 TYR 3 169 REMARK 465 SER 3 170 REMARK 465 LEU 3 171 REMARK 465 SER 3 172 REMARK 465 SER 3 173 REMARK 465 VAL 3 174 REMARK 465 VAL 3 175 REMARK 465 THR 3 176 REMARK 465 VAL 3 177 REMARK 465 PRO 3 178 REMARK 465 SER 3 179 REMARK 465 SER 3 180 REMARK 465 SER 3 181 REMARK 465 LEU 3 182 REMARK 465 GLY 3 183 REMARK 465 THR 3 184 REMARK 465 GLN 3 185 REMARK 465 THR 3 186 REMARK 465 TYR 3 187 REMARK 465 ILE 3 188 REMARK 465 CYS 3 189 REMARK 465 ASN 3 190 REMARK 465 VAL 3 191 REMARK 465 ASN 3 192 REMARK 465 HIS 3 193 REMARK 465 LYS 3 194 REMARK 465 PRO 3 195 REMARK 465 SER 3 196 REMARK 465 ASN 3 197 REMARK 465 THR 3 198 REMARK 465 LYS 3 199 REMARK 465 VAL 3 200 REMARK 465 ASP 3 201 REMARK 465 LYS 3 202 REMARK 465 LYS 3 203 REMARK 465 ALA 3 204 REMARK 465 GLU 3 205 REMARK 465 PRO 3 206 REMARK 465 THR 4 109 REMARK 465 VAL 4 110 REMARK 465 ALA 4 111 REMARK 465 ALA 4 112 REMARK 465 PRO 4 113 REMARK 465 SER 4 114 REMARK 465 VAL 4 115 REMARK 465 PHE 4 116 REMARK 465 ILE 4 117 REMARK 465 PHE 4 118 REMARK 465 PRO 4 119 REMARK 465 PRO 4 120 REMARK 465 SER 4 121 REMARK 465 ASP 4 122 REMARK 465 GLU 4 123 REMARK 465 GLN 4 124 REMARK 465 LEU 4 125 REMARK 465 LYS 4 126 REMARK 465 SER 4 127 REMARK 465 GLY 4 128 REMARK 465 THR 4 129 REMARK 465 ALA 4 130 REMARK 465 SER 4 131 REMARK 465 VAL 4 132 REMARK 465 VAL 4 133 REMARK 465 CYS 4 134 REMARK 465 LEU 4 135 REMARK 465 LEU 4 136 REMARK 465 ASN 4 137 REMARK 465 ASN 4 138 REMARK 465 PHE 4 139 REMARK 465 TYR 4 140 REMARK 465 PRO 4 141 REMARK 465 ARG 4 142 REMARK 465 GLU 4 143 REMARK 465 ALA 4 144 REMARK 465 LYS 4 145 REMARK 465 VAL 4 146 REMARK 465 GLN 4 147 REMARK 465 TRP 4 148 REMARK 465 LYS 4 149 REMARK 465 VAL 4 150 REMARK 465 ASP 4 151 REMARK 465 ASN 4 152 REMARK 465 ALA 4 153 REMARK 465 LEU 4 154 REMARK 465 GLN 4 155 REMARK 465 SER 4 156 REMARK 465 GLY 4 157 REMARK 465 ASN 4 158 REMARK 465 SER 4 159 REMARK 465 GLN 4 160 REMARK 465 GLU 4 161 REMARK 465 SER 4 162 REMARK 465 VAL 4 163 REMARK 465 THR 4 164 REMARK 465 GLU 4 165 REMARK 465 GLN 4 166 REMARK 465 ASP 4 167 REMARK 465 SER 4 168 REMARK 465 LYS 4 169 REMARK 465 ASP 4 170 REMARK 465 SER 4 171 REMARK 465 THR 4 172 REMARK 465 TYR 4 173 REMARK 465 SER 4 174 REMARK 465 LEU 4 175 REMARK 465 SER 4 176 REMARK 465 SER 4 177 REMARK 465 THR 4 178 REMARK 465 LEU 4 179 REMARK 465 THR 4 180 REMARK 465 LEU 4 181 REMARK 465 SER 4 182 REMARK 465 LYS 4 183 REMARK 465 ALA 4 184 REMARK 465 ASP 4 185 REMARK 465 TYR 4 186 REMARK 465 GLU 4 187 REMARK 465 LYS 4 188 REMARK 465 HIS 4 189 REMARK 465 LYS 4 190 REMARK 465 VAL 4 191 REMARK 465 TYR 4 192 REMARK 465 ALA 4 193 REMARK 465 CYS 4 194 REMARK 465 GLU 4 195 REMARK 465 VAL 4 196 REMARK 465 THR 4 197 REMARK 465 HIS 4 198 REMARK 465 GLN 4 199 REMARK 465 GLY 4 200 REMARK 465 LEU 4 201 REMARK 465 SER 4 202 REMARK 465 SER 4 203 REMARK 465 PRO 4 204 REMARK 465 VAL 4 205 REMARK 465 THR 4 206 REMARK 465 LYS 4 207 REMARK 465 SER 4 208 REMARK 465 PHE 4 209 REMARK 465 ASN 4 210 REMARK 465 ARG 4 211 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN 1 611 C1 NAG 1 705 1.63 REMARK 500 ND2 ASN D 611 C1 NAG D 705 1.63 REMARK 500 ND2 ASN d 611 C1 NAG d 705 1.64 REMARK 500 O GLY 2 263 CG2 THR 2 450 1.65 REMARK 500 O GLY C 263 CG2 THR C 450 1.66 REMARK 500 O GLY c 263 CG2 THR c 450 1.66 REMARK 500 ND2 ASN d 618 C2 NAG d 701 1.72 REMARK 500 ND2 ASN 1 618 C2 NAG 1 701 1.72 REMARK 500 ND2 ASN D 618 C2 NAG D 701 1.72 REMARK 500 ND2 ASN c 197 O5 NAG c 624 1.79 REMARK 500 ND2 ASN 2 197 O5 NAG 2 624 1.79 REMARK 500 ND2 ASN C 197 O5 NAG C 624 1.79 REMARK 500 O LYS c 502 CD2 LEU 1 661 1.86 REMARK 500 ND2 ASN c 156 O5 NAG c 609 1.89 REMARK 500 ND2 ASN C 156 O5 NAG C 609 1.89 REMARK 500 ND2 ASN 2 156 O5 NAG 2 609 1.89 REMARK 500 CD2 LEU D 661 O LYS 2 502 1.92 REMARK 500 OE2 GLU C 164 NH1 ARG C 308 1.92 REMARK 500 O LYS C 502 CD2 LEU d 661 1.95 REMARK 500 N GLY 2 263 OG1 THR 2 450 2.01 REMARK 500 N GLY c 263 OG1 THR c 450 2.02 REMARK 500 N GLY C 263 OG1 THR C 450 2.04 REMARK 500 OE2 GLU D 584 CG ARG 1 579 2.05 REMARK 500 CG ARG d 579 OE2 GLU 1 584 2.07 REMARK 500 ND2 ASN c 363 O5 NAG c 655 2.07 REMARK 500 ND2 ASN C 363 O5 NAG C 655 2.07 REMARK 500 ND2 ASN 2 363 O5 NAG 2 655 2.07 REMARK 500 ND2 ASN c 234 O5 NAG c 626 2.07 REMARK 500 ND2 ASN 2 234 O5 NAG 2 626 2.07 REMARK 500 ND2 ASN C 234 O5 NAG C 626 2.07 REMARK 500 ND2 ASN 1 618 O5 NAG 1 701 2.08 REMARK 500 ND2 ASN D 618 O5 NAG D 701 2.08 REMARK 500 ND2 ASN d 618 O5 NAG d 701 2.08 REMARK 500 OD1 ASP 2 140 O6 NAG 2 604 2.08 REMARK 500 CE2 TYR 6 35 OE1 GLN 6 88 2.08 REMARK 500 OD1 ASP c 140 O6 NAG c 604 2.08 REMARK 500 OD1 ASP C 140 O6 NAG C 604 2.08 REMARK 500 OD2 ASP L 28 OH TYR L 32 2.10 REMARK 500 OD2 ASP l 28 OH TYR l 32 2.10 REMARK 500 OD2 ASP 4 28 OH TYR 4 32 2.10 REMARK 500 CE2 TYR r 35 OE1 GLN r 88 2.12 REMARK 500 CD2 LEU C 165 OG1 THR c 128 2.12 REMARK 500 CG ARG D 579 OE2 GLU d 584 2.13 REMARK 500 NE2 GLN D 591 O ALA 1 541 2.13 REMARK 500 ND2 ASN C 392 C2 NAG C 662 2.15 REMARK 500 ND2 ASN c 392 C2 NAG c 662 2.15 REMARK 500 ND2 ASN 2 392 C2 NAG 2 662 2.15 REMARK 500 O ALA d 541 NE2 GLN 1 591 2.16 REMARK 500 OD2 ASP c 457 NH1 ARG c 469 2.17 REMARK 500 CD2 LEU c 165 OG1 THR 2 128 2.17 REMARK 500 REMARK 500 THIS ENTRY HAS 61 CLOSE CONTACTS REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS h 22 CA - CB - SG ANGL. DEV. = 6.7 DEGREES REMARK 500 CYS H 22 CA - CB - SG ANGL. DEV. = 6.7 DEGREES REMARK 500 CYS 3 22 CA - CB - SG ANGL. DEV. = 6.7 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PRO l 8 -155.92 -83.62 REMARK 500 TYR l 49 -140.31 -89.12 REMARK 500 VAL l 51 -30.31 -135.02 REMARK 500 THR l 92 -63.74 -92.89 REMARK 500 THR M 86 -168.87 -123.54 REMARK 500 ALA M 88 32.50 -94.50 REMARK 500 PRO N 44 -176.04 -70.00 REMARK 500 THR R 50 -14.69 72.27 REMARK 500 PHE R 90 -128.48 53.61 REMARK 500 THR D 536 32.37 -98.45 REMARK 500 THR D 606 -168.04 -125.55 REMARK 500 ASN D 616 47.39 35.20 REMARK 500 LYS C 65 63.10 64.58 REMARK 500 LEU C 122 42.67 -107.17 REMARK 500 CYS C 126 92.94 -69.01 REMARK 500 GLU C 153 -13.45 76.03 REMARK 500 THR C 163 -169.77 -120.48 REMARK 500 SER C 264 122.25 -39.42 REMARK 500 PHE C 391 58.11 -99.46 REMARK 500 TRP C 427 -1.45 68.32 REMARK 500 SER C 460 -165.15 -169.12 REMARK 500 ASN C 462 36.72 37.82 REMARK 500 PRO L 8 -155.82 -83.75 REMARK 500 TYR L 49 -140.23 -89.17 REMARK 500 VAL L 51 -30.22 -135.02 REMARK 500 THR L 92 -63.70 -92.87 REMARK 500 THR m 86 -168.85 -123.51 REMARK 500 ALA m 88 32.45 -94.50 REMARK 500 THR r 50 -14.63 72.25 REMARK 500 PHE r 90 -128.85 54.12 REMARK 500 THR d 536 32.32 -98.43 REMARK 500 THR d 606 -168.05 -125.56 REMARK 500 ASN d 616 47.37 35.20 REMARK 500 LYS c 65 63.15 64.56 REMARK 500 LEU c 122 42.64 -107.14 REMARK 500 CYS c 126 93.00 -69.06 REMARK 500 GLU c 153 -13.43 76.07 REMARK 500 THR c 163 -169.77 -120.46 REMARK 500 SER c 264 122.23 -39.15 REMARK 500 PHE c 391 58.13 -99.50 REMARK 500 TRP c 427 -1.45 68.28 REMARK 500 SER c 460 -165.17 -169.11 REMARK 500 ASN c 462 36.70 37.80 REMARK 500 THR 7 86 -168.88 -123.54 REMARK 500 ALA 7 88 32.51 -94.50 REMARK 500 PRO 8 44 -176.10 -69.98 REMARK 500 THR 6 50 -14.66 72.24 REMARK 500 PHE 6 90 -128.52 53.96 REMARK 500 THR 1 536 32.43 -98.48 REMARK 500 THR 1 606 -168.07 -125.60 REMARK 500 REMARK 500 THIS ENTRY HAS 65 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG D 705 REMARK 610 MAN C 615 REMARK 610 NAG d 705 REMARK 610 MAN c 615 REMARK 610 NAG 1 705 REMARK 610 MAN 2 615 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-7459 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY REMARK 900 VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES REMARK 900 VRC03 AND PGT122 DBREF 6CDE M 1 228 PDB 6CDE 6CDE 1 228 DBREF 6CDE N 6 210 PDB 6CDE 6CDE 6 210 DBREF 6CDE R 1 208 PDB 6CDE 6CDE 1 208 DBREF 6CDE Q 1 210 PDB 6CDE 6CDE 1 210 DBREF 6CDE D 512 664 UNP Q2N0S7 Q2N0S7_9HIV1 509 661 DBREF 6CDE C 31 505 UNP Q2N0S5 Q2N0S5_9HIV1 30 502 DBREF 6CDE H 1 206 PDB 6CDE 6CDE 1 206 DBREF 6CDE L 1 211 PDB 6CDE 6CDE 1 211 DBREF 6CDE m 1 228 PDB 6CDE 6CDE 1 228 DBREF 6CDE n 6 210 PDB 6CDE 6CDE 6 210 DBREF 6CDE r 1 208 PDB 6CDE 6CDE 1 208 DBREF 6CDE q 1 210 PDB 6CDE 6CDE 1 210 DBREF 6CDE d 512 664 UNP Q2N0S7 Q2N0S7_9HIV1 509 661 DBREF 6CDE c 31 505 UNP Q2N0S5 Q2N0S5_9HIV1 30 502 DBREF 6CDE h 1 206 PDB 6CDE 6CDE 1 206 DBREF 6CDE l 1 211 PDB 6CDE 6CDE 1 211 DBREF 6CDE 7 1 228 PDB 6CDE 6CDE 1 228 DBREF 6CDE 8 6 210 PDB 6CDE 6CDE 6 210 DBREF 6CDE 6 1 208 PDB 6CDE 6CDE 1 208 DBREF 6CDE 5 1 210 PDB 6CDE 6CDE 1 210 DBREF 6CDE 1 512 664 UNP Q2N0S7 Q2N0S7_9HIV1 509 661 DBREF 6CDE 2 31 505 UNP Q2N0S5 Q2N0S5_9HIV1 30 502 DBREF 6CDE 3 1 206 PDB 6CDE 6CDE 1 206 DBREF 6CDE 4 1 211 PDB 6CDE 6CDE 1 211 SEQADV 6CDE CYS D 605 UNP Q2N0S7 THR 602 CONFLICT SEQADV 6CDE CYS C 201 UNP Q2N0S5 ILE 200 CONFLICT SEQADV 6CDE ASN C 332 UNP Q2N0S5 THR 330 CONFLICT SEQADV 6CDE CYS C 433 UNP Q2N0S5 ALA 430 CONFLICT SEQADV 6CDE CYS C 501 UNP Q2N0S5 ALA 498 CONFLICT SEQADV 6CDE CYS d 605 UNP Q2N0S7 THR 602 CONFLICT SEQADV 6CDE CYS c 201 UNP Q2N0S5 ILE 200 CONFLICT SEQADV 6CDE ASN c 332 UNP Q2N0S5 THR 330 CONFLICT SEQADV 6CDE CYS c 433 UNP Q2N0S5 ALA 430 CONFLICT SEQADV 6CDE CYS c 501 UNP Q2N0S5 ALA 498 CONFLICT SEQADV 6CDE CYS 1 605 UNP Q2N0S7 THR 602 CONFLICT SEQADV 6CDE CYS 2 201 UNP Q2N0S5 ILE 200 CONFLICT SEQADV 6CDE ASN 2 332 UNP Q2N0S5 THR 330 CONFLICT SEQADV 6CDE CYS 2 433 UNP Q2N0S5 ALA 430 CONFLICT SEQADV 6CDE CYS 2 501 UNP Q2N0S5 ALA 498 CONFLICT SEQRES 1 h 211 GLN VAL GLN LEU GLN GLN SER GLY ALA ASP LEU VAL ARG SEQRES 2 h 211 PRO GLY ALA SER VAL THR LEU SER CYS LYS ALA SER GLY SEQRES 3 h 211 TYR THR PHE THR ASP TYR GLU MET HIS TRP MET LYS GLN SEQRES 4 h 211 THR PRO VAL HIS GLY LEU GLU TRP ILE GLY ALA ILE VAL SEQRES 5 h 211 PRO GLU THR GLY TYR THR ALA TYR ASN GLN LYS PHE LYS SEQRES 6 h 211 GLY LYS ALA ILE LEU THR ALA ASP LYS SER SER ASN THR SEQRES 7 h 211 VAL TYR MET GLN PHE ARG SER LEU THR SER GLU ASP SER SEQRES 8 h 211 ALA VAL TYR TYR CYS SER ARG LEU LYS LEU LEU GLY TYR SEQRES 9 h 211 PHE ASP VAL TRP GLY THR GLY THR THR VAL THR VAL SER SEQRES 10 h 211 PRO ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 h 211 PRO GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 12 h 211 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 13 h 211 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 14 h 211 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 15 h 211 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 16 h 211 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 17 h 211 ALA GLU PRO SEQRES 1 l 216 ASP VAL LEU MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 l 216 SER LEU GLY ASP GLN ALA SER ILE SER CYS LYS SER SER SEQRES 3 l 216 GLN SER ILE VAL TYR LYS ASP GLY ASN SER TYR LEU GLU SEQRES 4 l 216 TRP TYR LEU GLN LYS VAL GLY GLN SER PRO LYS LEU LEU SEQRES 5 l 216 ILE TYR ARG VAL SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 l 216 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 l 216 LYS ILE SER ARG VAL GLU ALA GLU ASP LEU GLY VAL TYR SEQRES 8 l 216 TYR CYS PHE GLN GLY THR HIS LEU PRO TYR THR PHE GLY SEQRES 9 l 216 GLY GLY THR LYS LEU GLU MET LYS ARG THR VAL ALA ALA SEQRES 10 l 216 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 l 216 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 l 216 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 l 216 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 l 216 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 l 216 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 l 216 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 l 216 PRO VAL THR LYS SER PHE ASN ARG SEQRES 1 M 228 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 M 228 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 M 228 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 M 228 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 M 228 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 M 228 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 M 228 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 M 228 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 M 228 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 M 228 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 M 228 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 M 228 ALA PRO SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 M 228 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 M 228 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 M 228 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 M 228 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 M 228 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 M 228 VAL ASP LYS ARG VAL GLU PRO SEQRES 1 N 210 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 N 210 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 N 210 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 N 210 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 N 210 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 N 210 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 N 210 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 N 210 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 N 210 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 N 210 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 N 210 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 N 210 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 N 210 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 N 210 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 N 210 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 N 210 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 N 210 PRO THR SEQRES 1 R 208 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 R 208 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 R 208 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 R 208 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 R 208 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 R 208 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 R 208 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 R 208 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 R 208 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 R 208 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 R 208 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 R 208 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 R 208 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 R 208 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 R 208 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 R 208 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 1 Q 227 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 Q 227 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 Q 227 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 Q 227 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 Q 227 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 Q 227 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 Q 227 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 Q 227 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 Q 227 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 Q 227 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 Q 227 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 Q 227 SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 Q 227 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 Q 227 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 Q 227 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 Q 227 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 Q 227 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 Q 227 LYS LYS VAL GLU PRO LYS SEQRES 1 D 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 D 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 D 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 D 153 GLN GLN SER ASN LEU LEU ARG ALA ILE GLU ALA GLN GLN SEQRES 5 D 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 D 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 D 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 D 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 D 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 D 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 D 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 D 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 C 473 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 C 473 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 C 473 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 C 473 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 C 473 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 C 473 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 C 473 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 C 473 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 C 473 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 C 473 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 C 473 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 C 473 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 C 473 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 C 473 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 C 473 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 C 473 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 C 473 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 C 473 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 C 473 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 C 473 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 C 473 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 C 473 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 C 473 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 C 473 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 C 473 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 C 473 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 C 473 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 C 473 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 C 473 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 C 473 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 C 473 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 C 473 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 C 473 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 C 473 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 C 473 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 C 473 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 C 473 CYS LYS ARG ARG VAL SEQRES 1 H 211 GLN VAL GLN LEU GLN GLN SER GLY ALA ASP LEU VAL ARG SEQRES 2 H 211 PRO GLY ALA SER VAL THR LEU SER CYS LYS ALA SER GLY SEQRES 3 H 211 TYR THR PHE THR ASP TYR GLU MET HIS TRP MET LYS GLN SEQRES 4 H 211 THR PRO VAL HIS GLY LEU GLU TRP ILE GLY ALA ILE VAL SEQRES 5 H 211 PRO GLU THR GLY TYR THR ALA TYR ASN GLN LYS PHE LYS SEQRES 6 H 211 GLY LYS ALA ILE LEU THR ALA ASP LYS SER SER ASN THR SEQRES 7 H 211 VAL TYR MET GLN PHE ARG SER LEU THR SER GLU ASP SER SEQRES 8 H 211 ALA VAL TYR TYR CYS SER ARG LEU LYS LEU LEU GLY TYR SEQRES 9 H 211 PHE ASP VAL TRP GLY THR GLY THR THR VAL THR VAL SER SEQRES 10 H 211 PRO ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 H 211 PRO GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 12 H 211 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 13 H 211 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 14 H 211 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 15 H 211 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 16 H 211 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 17 H 211 ALA GLU PRO SEQRES 1 L 216 ASP VAL LEU MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 L 216 SER LEU GLY ASP GLN ALA SER ILE SER CYS LYS SER SER SEQRES 3 L 216 GLN SER ILE VAL TYR LYS ASP GLY ASN SER TYR LEU GLU SEQRES 4 L 216 TRP TYR LEU GLN LYS VAL GLY GLN SER PRO LYS LEU LEU SEQRES 5 L 216 ILE TYR ARG VAL SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 L 216 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 L 216 LYS ILE SER ARG VAL GLU ALA GLU ASP LEU GLY VAL TYR SEQRES 8 L 216 TYR CYS PHE GLN GLY THR HIS LEU PRO TYR THR PHE GLY SEQRES 9 L 216 GLY GLY THR LYS LEU GLU MET LYS ARG THR VAL ALA ALA SEQRES 10 L 216 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 L 216 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 216 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 L 216 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 216 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 L 216 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 L 216 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 216 PRO VAL THR LYS SER PHE ASN ARG SEQRES 1 m 228 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 m 228 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 m 228 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 m 228 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 m 228 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 m 228 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 m 228 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 m 228 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 m 228 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 m 228 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 m 228 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 m 228 ALA PRO SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 m 228 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 m 228 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 m 228 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 m 228 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 m 228 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 m 228 VAL ASP LYS ARG VAL GLU PRO SEQRES 1 n 210 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 n 210 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 n 210 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 n 210 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 n 210 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 n 210 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 n 210 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 n 210 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 n 210 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 n 210 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 n 210 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 n 210 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 n 210 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 n 210 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 n 210 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 n 210 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 n 210 PRO THR SEQRES 1 r 208 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 r 208 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 r 208 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 r 208 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 r 208 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 r 208 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 r 208 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 r 208 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 r 208 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 r 208 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 r 208 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 r 208 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 r 208 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 r 208 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 r 208 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 r 208 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 1 q 227 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 q 227 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 q 227 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 q 227 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 q 227 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 q 227 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 q 227 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 q 227 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 q 227 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 q 227 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 q 227 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 q 227 SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 q 227 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 q 227 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 q 227 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 q 227 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 q 227 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 q 227 LYS LYS VAL GLU PRO LYS SEQRES 1 d 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 d 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 d 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 d 153 GLN GLN SER ASN LEU LEU ARG ALA ILE GLU ALA GLN GLN SEQRES 5 d 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 d 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 d 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 d 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 d 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 d 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 d 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 d 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 c 473 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 c 473 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 c 473 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 c 473 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 c 473 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 c 473 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 c 473 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 c 473 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 c 473 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 c 473 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 c 473 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 c 473 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 c 473 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 c 473 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 c 473 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 c 473 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 c 473 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 c 473 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 c 473 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 c 473 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 c 473 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 c 473 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 c 473 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 c 473 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 c 473 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 c 473 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 c 473 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 c 473 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 c 473 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 c 473 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 c 473 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 c 473 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 c 473 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 c 473 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 c 473 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 c 473 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 c 473 CYS LYS ARG ARG VAL SEQRES 1 7 228 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 7 228 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 7 228 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 7 228 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 7 228 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 7 228 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 7 228 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 7 228 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 7 228 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 7 228 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 7 228 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 7 228 ALA PRO SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 7 228 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 7 228 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 7 228 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 7 228 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 7 228 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 7 228 VAL ASP LYS ARG VAL GLU PRO SEQRES 1 8 210 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 8 210 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 8 210 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 8 210 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 8 210 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 8 210 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 8 210 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 8 210 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 8 210 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 8 210 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 8 210 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 8 210 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 8 210 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 8 210 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 8 210 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 8 210 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 8 210 PRO THR SEQRES 1 6 208 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 6 208 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 6 208 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 6 208 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 6 208 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 6 208 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 6 208 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 6 208 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 6 208 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 6 208 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 6 208 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 6 208 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 6 208 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 6 208 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 6 208 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 6 208 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 1 5 227 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 5 227 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 5 227 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 5 227 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 5 227 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 5 227 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 5 227 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 5 227 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 5 227 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 5 227 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 5 227 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 5 227 SER SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 5 227 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 5 227 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 5 227 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 5 227 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 5 227 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 5 227 LYS LYS VAL GLU PRO LYS SEQRES 1 1 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 1 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 1 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 1 153 GLN GLN SER ASN LEU LEU ARG ALA ILE GLU ALA GLN GLN SEQRES 5 1 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 1 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 1 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 1 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 1 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 1 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 1 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 1 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 2 473 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 2 473 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 2 473 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 2 473 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 2 473 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 2 473 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 2 473 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 2 473 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 2 473 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 2 473 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 2 473 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 2 473 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 2 473 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 2 473 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 2 473 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 2 473 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 2 473 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 2 473 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 2 473 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 2 473 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 2 473 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 2 473 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 2 473 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 2 473 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 2 473 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 2 473 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 2 473 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 2 473 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 2 473 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 2 473 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 2 473 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 2 473 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 2 473 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 2 473 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 2 473 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 2 473 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 2 473 CYS LYS ARG ARG VAL SEQRES 1 3 211 GLN VAL GLN LEU GLN GLN SER GLY ALA ASP LEU VAL ARG SEQRES 2 3 211 PRO GLY ALA SER VAL THR LEU SER CYS LYS ALA SER GLY SEQRES 3 3 211 TYR THR PHE THR ASP TYR GLU MET HIS TRP MET LYS GLN SEQRES 4 3 211 THR PRO VAL HIS GLY LEU GLU TRP ILE GLY ALA ILE VAL SEQRES 5 3 211 PRO GLU THR GLY TYR THR ALA TYR ASN GLN LYS PHE LYS SEQRES 6 3 211 GLY LYS ALA ILE LEU THR ALA ASP LYS SER SER ASN THR SEQRES 7 3 211 VAL TYR MET GLN PHE ARG SER LEU THR SER GLU ASP SER SEQRES 8 3 211 ALA VAL TYR TYR CYS SER ARG LEU LYS LEU LEU GLY TYR SEQRES 9 3 211 PHE ASP VAL TRP GLY THR GLY THR THR VAL THR VAL SER SEQRES 10 3 211 PRO ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 3 211 PRO GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 12 3 211 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 13 3 211 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 14 3 211 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 15 3 211 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 16 3 211 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 17 3 211 ALA GLU PRO SEQRES 1 4 216 ASP VAL LEU MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 4 216 SER LEU GLY ASP GLN ALA SER ILE SER CYS LYS SER SER SEQRES 3 4 216 GLN SER ILE VAL TYR LYS ASP GLY ASN SER TYR LEU GLU SEQRES 4 4 216 TRP TYR LEU GLN LYS VAL GLY GLN SER PRO LYS LEU LEU SEQRES 5 4 216 ILE TYR ARG VAL SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 4 216 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 4 216 LYS ILE SER ARG VAL GLU ALA GLU ASP LEU GLY VAL TYR SEQRES 8 4 216 TYR CYS PHE GLN GLY THR HIS LEU PRO TYR THR PHE GLY SEQRES 9 4 216 GLY GLY THR LYS LEU GLU MET LYS ARG THR VAL ALA ALA SEQRES 10 4 216 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 4 216 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 4 216 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 4 216 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 4 216 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 4 216 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 4 216 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 4 216 PRO VAL THR LYS SER PHE ASN ARG HET NAG D 701 14 HET NAG D 702 14 HET NAG D 703 14 HET BMA D 704 11 HET NAG D 705 14 HET NAG D 706 14 HET BMA D 707 11 HET NAG C 601 14 HET NAG C 602 14 HET NAG C 603 14 HET NAG C 604 14 HET NAG C 605 14 HET NAG C 606 14 HET BMA C 607 11 HET MAN C 608 11 HET NAG C 609 14 HET NAG C 610 14 HET BMA C 611 11 HET MAN C 612 11 HET MAN C 613 11 HET MAN C 614 11 HET MAN C 615 11 HET NAG C 616 14 HET NAG C 617 14 HET BMA C 618 11 HET MAN C 619 11 HET MAN C 620 11 HET MAN C 621 11 HET MAN C 622 11 HET MAN C 623 11 HET NAG C 624 14 HET NAG C 625 14 HET NAG C 626 14 HET NAG C 627 14 HET BMA C 628 11 HET MAN C 629 11 HET MAN C 630 11 HET NAG C 631 14 HET NAG C 632 14 HET BMA C 633 11 HET MAN C 634 11 HET MAN C 635 11 HET MAN C 636 11 HET MAN C 637 11 HET MAN C 638 11 HET NAG C 639 14 HET NAG C 640 14 HET NAG C 641 14 HET NAG C 642 14 HET BMA C 643 11 HET NAG C 644 14 HET NAG C 645 14 HET BMA C 646 11 HET MAN C 647 11 HET MAN C 648 11 HET MAN C 649 11 HET MAN C 650 11 HET MAN C 651 11 HET MAN C 652 11 HET NAG C 653 14 HET NAG C 654 14 HET NAG C 655 14 HET NAG C 656 14 HET BMA C 657 11 HET NAG C 658 14 HET NAG C 659 14 HET BMA C 660 11 HET MAN C 661 11 HET NAG C 662 14 HET NAG C 663 14 HET BMA C 664 11 HET NAG C 665 14 HET NAG C 666 14 HET BMA C 667 11 HET NAG d 701 14 HET NAG d 702 14 HET NAG d 703 14 HET BMA d 704 11 HET NAG d 705 14 HET NAG d 706 14 HET BMA d 707 11 HET NAG c 601 14 HET NAG c 602 14 HET NAG c 603 14 HET NAG c 604 14 HET NAG c 605 14 HET NAG c 606 14 HET BMA c 607 11 HET MAN c 608 11 HET NAG c 609 14 HET NAG c 610 14 HET BMA c 611 11 HET MAN c 612 11 HET MAN c 613 11 HET MAN c 614 11 HET MAN c 615 11 HET NAG c 616 14 HET NAG c 617 14 HET BMA c 618 11 HET MAN c 619 11 HET MAN c 620 11 HET MAN c 621 11 HET MAN c 622 11 HET MAN c 623 11 HET NAG c 624 14 HET NAG c 625 14 HET NAG c 626 14 HET NAG c 627 14 HET BMA c 628 11 HET MAN c 629 11 HET MAN c 630 11 HET NAG c 631 14 HET NAG c 632 14 HET BMA c 633 11 HET MAN c 634 11 HET MAN c 635 11 HET MAN c 636 11 HET MAN c 637 11 HET MAN c 638 11 HET NAG c 639 14 HET NAG c 640 14 HET NAG c 641 14 HET NAG c 642 14 HET BMA c 643 11 HET NAG c 644 14 HET NAG c 645 14 HET BMA c 646 11 HET MAN c 647 11 HET MAN c 648 11 HET MAN c 649 11 HET MAN c 650 11 HET MAN c 651 11 HET MAN c 652 11 HET NAG c 653 14 HET NAG c 654 14 HET NAG c 655 14 HET NAG c 656 14 HET BMA c 657 11 HET NAG c 658 14 HET NAG c 659 14 HET BMA c 660 11 HET MAN c 661 11 HET NAG c 662 14 HET NAG c 663 14 HET BMA c 664 11 HET NAG c 665 14 HET NAG c 666 14 HET BMA c 667 11 HET NAG 1 701 14 HET NAG 1 702 14 HET NAG 1 703 14 HET BMA 1 704 11 HET NAG 1 705 14 HET NAG 1 706 14 HET BMA 1 707 11 HET NAG 2 601 14 HET NAG 2 602 14 HET NAG 2 603 14 HET NAG 2 604 14 HET NAG 2 605 14 HET NAG 2 606 14 HET BMA 2 607 11 HET MAN 2 608 11 HET NAG 2 609 14 HET NAG 2 610 14 HET BMA 2 611 11 HET MAN 2 612 11 HET MAN 2 613 11 HET MAN 2 614 11 HET MAN 2 615 11 HET NAG 2 616 14 HET NAG 2 617 14 HET BMA 2 618 11 HET MAN 2 619 11 HET MAN 2 620 11 HET MAN 2 621 11 HET MAN 2 622 11 HET MAN 2 623 11 HET NAG 2 624 14 HET NAG 2 625 14 HET NAG 2 626 14 HET NAG 2 627 14 HET BMA 2 628 11 HET MAN 2 629 11 HET MAN 2 630 11 HET NAG 2 631 14 HET NAG 2 632 14 HET BMA 2 633 11 HET MAN 2 634 11 HET MAN 2 635 11 HET MAN 2 636 11 HET MAN 2 637 11 HET MAN 2 638 11 HET NAG 2 639 14 HET NAG 2 640 14 HET NAG 2 641 14 HET NAG 2 642 14 HET BMA 2 643 11 HET NAG 2 644 14 HET NAG 2 645 14 HET BMA 2 646 11 HET MAN 2 647 11 HET MAN 2 648 11 HET MAN 2 649 11 HET MAN 2 650 11 HET MAN 2 651 11 HET MAN 2 652 11 HET NAG 2 653 14 HET NAG 2 654 14 HET NAG 2 655 14 HET NAG 2 656 14 HET BMA 2 657 11 HET NAG 2 658 14 HET NAG 2 659 14 HET BMA 2 660 11 HET MAN 2 661 11 HET NAG 2 662 14 HET NAG 2 663 14 HET BMA 2 664 11 HET NAG 2 665 14 HET NAG 2 666 14 HET BMA 2 667 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 25 NAG 111(C8 H15 N O6) FORMUL 26 BMA 39(C6 H12 O6) FORMUL 30 MAN 72(C6 H12 O6) HELIX 1 AA1 THR M 86 SER M 90 5 5 HELIX 2 AA2 VAL M 107 LYS M 111 5 5 HELIX 3 AA3 ARG Q 61 GLN Q 64 5 4 HELIX 4 AA4 THR Q 83 THR Q 87 5 5 HELIX 5 AA5 ILE D 515 LEU D 520 1 6 HELIX 6 AA6 LEU D 523 GLY D 527 5 5 HELIX 7 AA7 THR D 529 SER D 534 1 6 HELIX 8 AA8 LEU D 537 ASN D 543 1 7 HELIX 9 AA9 VAL D 570 ILE D 595 1 26 HELIX 10 AB1 SER D 620 ASN D 625 1 6 HELIX 11 AB2 THR D 627 LYS D 633 1 7 HELIX 12 AB3 TYR D 638 LEU D 663 1 26 HELIX 13 AB4 ALA C 58 THR C 63 5 6 HELIX 14 AB5 ASN C 99 SER C 115 1 17 HELIX 15 AB6 TYR C 177 LEU C 179 5 3 HELIX 16 AB7 ASN C 195 THR C 198 5 4 HELIX 17 AB8 LYS C 335 GLY C 354 1 20 HELIX 18 AB9 ASP C 368 THR C 373 1 6 HELIX 19 AC1 ARG C 476 SER C 481 1 6 HELIX 20 AC2 THR m 86 SER m 90 5 5 HELIX 21 AC3 VAL m 107 LYS m 111 5 5 HELIX 22 AC4 ARG q 61 GLN q 64 5 4 HELIX 23 AC5 THR q 83 THR q 87 5 5 HELIX 24 AC6 ILE d 515 LEU d 520 1 6 HELIX 25 AC7 LEU d 523 GLY d 527 5 5 HELIX 26 AC8 THR d 529 SER d 534 1 6 HELIX 27 AC9 LEU d 537 ASN d 543 1 7 HELIX 28 AD1 VAL d 570 ILE d 595 1 26 HELIX 29 AD2 SER d 620 ASN d 625 1 6 HELIX 30 AD3 THR d 627 LYS d 633 1 7 HELIX 31 AD4 TYR d 638 LEU d 663 1 26 HELIX 32 AD5 ALA c 58 THR c 63 5 6 HELIX 33 AD6 ASN c 99 SER c 115 1 17 HELIX 34 AD7 TYR c 177 LEU c 179 5 3 HELIX 35 AD8 ASN c 195 THR c 198 5 4 HELIX 36 AD9 LYS c 335 GLY c 354 1 20 HELIX 37 AE1 ASP c 368 THR c 373 1 6 HELIX 38 AE2 ARG c 476 SER c 481 1 6 HELIX 39 AE3 THR 7 86 SER 7 90 5 5 HELIX 40 AE4 VAL 7 107 LYS 7 111 5 5 HELIX 41 AE5 ARG 5 61 GLN 5 64 5 4 HELIX 42 AE6 THR 5 83 THR 5 87 5 5 HELIX 43 AE7 ILE 1 515 LEU 1 520 1 6 HELIX 44 AE8 LEU 1 523 GLY 1 527 5 5 HELIX 45 AE9 THR 1 529 SER 1 534 1 6 HELIX 46 AF1 LEU 1 537 ASN 1 543 1 7 HELIX 47 AF2 VAL 1 570 ILE 1 595 1 26 HELIX 48 AF3 SER 1 620 ASN 1 625 1 6 HELIX 49 AF4 THR 1 627 LYS 1 633 1 7 HELIX 50 AF5 TYR 1 638 LEU 1 663 1 26 HELIX 51 AF6 ALA 2 58 THR 2 63 5 6 HELIX 52 AF7 ASN 2 99 SER 2 115 1 17 HELIX 53 AF8 TYR 2 177 LEU 2 179 5 3 HELIX 54 AF9 ASN 2 195 THR 2 198 5 4 HELIX 55 AG1 LYS 2 335 GLY 2 354 1 20 HELIX 56 AG2 ASP 2 368 THR 2 373 1 6 HELIX 57 AG3 ARG 2 476 SER 2 481 1 6 SHEET 1 AA1 2 ASP h 10 LEU h 11 0 SHEET 2 AA1 2 VAL h 109 THR h 110 1 O THR h 110 N ASP h 10 SHEET 1 AA2 3 SER h 21 LYS h 23 0 SHEET 2 AA2 3 THR h 77 TYR h 79 -1 O VAL h 78 N CYS h 22 SHEET 3 AA2 3 THR h 70 ASP h 72 -1 N THR h 70 O TYR h 79 SHEET 1 AA3 4 GLY h 44 ILE h 51 0 SHEET 2 AA3 4 GLU h 33 THR h 40 -1 N THR h 40 O GLY h 44 SHEET 3 AA3 4 SER h 93 LEU h 95 -1 O LEU h 95 N GLU h 33 SHEET 4 AA3 4 PHE h 100A TRP h 103 -1 O ASP h 101 N ARG h 94 SHEET 1 AA4 4 THR l 5 THR l 7 0 SHEET 2 AA4 4 SER l 22 LYS l 24 -1 O SER l 22 N THR l 7 SHEET 3 AA4 4 ASP l 70 ILE l 75 -1 O PHE l 71 N CYS l 23 SHEET 4 AA4 4 PHE l 62 GLY l 66 -1 N SER l 65 O THR l 72 SHEET 1 AA5 3 LEU l 33 GLN l 38 0 SHEET 2 AA5 3 GLY l 84 GLN l 90 -1 O TYR l 87 N TYR l 36 SHEET 3 AA5 3 THR l 102 LEU l 104 -1 O THR l 102 N TYR l 86 SHEET 1 AA6 6 LEU M 11 VAL M 12 0 SHEET 2 AA6 6 THR M 126 VAL M 130 1 O THR M 129 N VAL M 12 SHEET 3 AA6 6 ALA M 91 TYR M 93 -1 N TYR M 93 O THR M 126 SHEET 4 AA6 6 TYR M 33 GLN M 39 -1 N GLN M 39 O ILE M 92 SHEET 5 AA6 6 GLU M 46 VAL M 51 -1 O GLU M 46 N ARG M 38 SHEET 6 AA6 6 THR M 57 ASN M 58 -1 O ASN M 58 N TYR M 50 SHEET 1 AA7 6 LEU M 11 VAL M 12 0 SHEET 2 AA7 6 THR M 126 VAL M 130 1 O THR M 129 N VAL M 12 SHEET 3 AA7 6 ALA M 91 TYR M 93 -1 N TYR M 93 O THR M 126 SHEET 4 AA7 6 TYR M 33 GLN M 39 -1 N GLN M 39 O ILE M 92 SHEET 5 AA7 6 ALA M 96 ARG M 102 -1 O ALA M 96 N SER M 35 SHEET 6 AA7 6 THR M 115 TYR M 118 -1 O TYR M 118 N LYS M 99 SHEET 1 AA8 2 LEU M 71 ASP M 72 0 SHEET 2 AA8 2 LEU M 77 VAL M 78 -1 O LEU M 77 N ASP M 72 SHEET 1 AA9 2 VAL N 11 VAL N 13 0 SHEET 2 AA9 2 LEU N 104 VAL N 106 1 O ILE N 105 N VAL N 11 SHEET 1 AB1 3 ALA N 19 THR N 22 0 SHEET 2 AB1 3 THR N 72 ILE N 75 -1 O ILE N 75 N ALA N 19 SHEET 3 AB1 3 PHE N 62 GLY N 64 -1 N SER N 63 O THR N 74 SHEET 1 AB2 2 ARG N 31 GLN N 38 0 SHEET 2 AB2 2 ASP N 85 ASP N 92 -1 O ASP N 85 N GLN N 38 SHEET 1 AB3 4 THR R 5 SER R 7 0 SHEET 2 AB3 4 ALA R 19 LYS R 24 -1 O LYS R 24 N THR R 5 SHEET 3 AB3 4 ASP R 69 ILE R 74 -1 O ILE R 74 N ALA R 19 SHEET 4 AB3 4 PHE R 61 SER R 66 -1 N VAL R 62 O THR R 73 SHEET 1 AB4 6 ILE R 10 LEU R 13 0 SHEET 2 AB4 6 SER R 97 VAL R 101 1 O GLU R 100 N LEU R 11 SHEET 3 AB4 6 VAL R 84 GLN R 89 -1 N TYR R 85 O SER R 97 SHEET 4 AB4 6 THR R 33 LYS R 37 -1 N THR R 33 O GLN R 88 SHEET 5 AB4 6 ARG R 44 TYR R 48 -1 O ARG R 44 N GLN R 36 SHEET 6 AB4 6 ARG R 52 ARG R 53 -1 O ARG R 52 N TYR R 48 SHEET 1 AB5 4 ILE R 10 LEU R 13 0 SHEET 2 AB5 4 SER R 97 VAL R 101 1 O GLU R 100 N LEU R 11 SHEET 3 AB5 4 VAL R 84 GLN R 89 -1 N TYR R 85 O SER R 97 SHEET 4 AB5 4 PHE R 92 PHE R 93 -1 O PHE R 92 N GLN R 89 SHEET 1 AB6 4 GLN Q 3 VAL Q 5 0 SHEET 2 AB6 4 SER Q 17 SER Q 25 -1 O SER Q 25 N GLN Q 3 SHEET 3 AB6 4 GLY Q 76G SER Q 82A-1 O GLY Q 76G N ALA Q 24 SHEET 4 AB6 4 VAL Q 67 GLN Q 72 -1 N SER Q 68 O GLU Q 81 SHEET 1 AB7 6 VAL Q 10 ILE Q 11 0 SHEET 2 AB7 6 THR Q 107 VAL Q 110 1 O VAL Q 108 N VAL Q 10 SHEET 3 AB7 6 ALA Q 88 ARG Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AB7 6 ILE Q 34 ILE Q 40 -1 N VAL Q 37 O PHE Q 91 SHEET 5 AB7 6 GLY Q 44 ILE Q 51 -1 O ILE Q 51 N ILE Q 34 SHEET 6 AB7 6 VAL Q 57 TYR Q 59 -1 O SER Q 58 N TRP Q 50 SHEET 1 AB8 4 VAL Q 10 ILE Q 11 0 SHEET 2 AB8 4 THR Q 107 VAL Q 110 1 O VAL Q 108 N VAL Q 10 SHEET 3 AB8 4 ALA Q 88 ARG Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AB8 4 TRP Q 100F TRP Q 103 -1 O TYR Q 102 N ARG Q 94 SHEET 1 AB9 2 TRP C 35 TYR C 40 0 SHEET 2 AB9 2 LEU C 494 THR C 499 -1 O ALA C 497 N THR C 37 SHEET 1 AC1 3 TRP C 45 ASP C 47 0 SHEET 2 AC1 3 TYR C 486 ILE C 491 -1 O LYS C 490 N LYS C 46 SHEET 3 AC1 3 PHE C 223 LYS C 227 -1 N ALA C 224 O VAL C 489 SHEET 1 AC2 3 VAL C 75 PRO C 76 0 SHEET 2 AC2 3 PHE C 53 SER C 56 1 N SER C 56 O VAL C 75 SHEET 3 AC2 3 ILE C 215 CYS C 218 -1 O HIS C 216 N ALA C 55 SHEET 1 AC3 2 ILE C 84 HIS C 85 0 SHEET 2 AC3 2 SER C 243 THR C 244 -1 O THR C 244 N ILE C 84 SHEET 1 AC4 2 GLU C 91 ASN C 94 0 SHEET 2 AC4 2 THR C 236 CYS C 239 -1 O GLY C 237 N PHE C 93 SHEET 1 AC5 3 GLN C 130 ASN C 133 0 SHEET 2 AC5 3 LYS C 155 THR C 162 -1 O SER C 158 N GLN C 130 SHEET 3 AC5 3 LYS C 169 PHE C 176 -1 O GLN C 170 N MET C 161 SHEET 1 AC6 2 VAL C 181 GLN C 183 0 SHEET 2 AC6 2 TYR C 191 LEU C 193 -1 O ARG C 192 N VAL C 182 SHEET 1 AC7 3 THR C 202 GLN C 203 0 SHEET 2 AC7 3 MET C 434 TYR C 435 1 O TYR C 435 N THR C 202 SHEET 3 AC7 3 ILE C 423 ILE C 424 -1 N ILE C 424 O MET C 434 SHEET 1 AC8 5 MET C 271 ARG C 273 0 SHEET 2 AC8 5 ILE C 284 ARG C 298 -1 O GLN C 287 N MET C 271 SHEET 3 AC8 5 ILE C 443 ARG C 456 -1 O THR C 450 N PHE C 288 SHEET 4 AC8 5 THR C 465 PRO C 470 -1 O ARG C 469 N THR C 455 SHEET 5 AC8 5 ILE C 358 PHE C 361 1 N ARG C 360 O PHE C 468 SHEET 1 AC9 6 MET C 271 ARG C 273 0 SHEET 2 AC9 6 ILE C 284 ARG C 298 -1 O GLN C 287 N MET C 271 SHEET 3 AC9 6 HIS C 330 SER C 334 -1 O ASN C 332 N ASN C 295 SHEET 4 AC9 6 SER C 413 ILE C 420 -1 O ILE C 414 N VAL C 333 SHEET 5 AC9 6 PHE C 382 CYS C 385 -1 N TYR C 384 O ARG C 419 SHEET 6 AC9 6 HIS C 374 ASN C 377 -1 N HIS C 374 O CYS C 385 SHEET 1 AD1 2 ARG C 304 GLY C 312 0 SHEET 2 AD1 2 GLN C 315 THR C 320 -1 O PHE C 317 N ILE C 307 SHEET 1 AD2 2 ASP H 10 LEU H 11 0 SHEET 2 AD2 2 VAL H 109 THR H 110 1 O THR H 110 N ASP H 10 SHEET 1 AD3 3 SER H 21 LYS H 23 0 SHEET 2 AD3 3 THR H 77 TYR H 79 -1 O VAL H 78 N CYS H 22 SHEET 3 AD3 3 THR H 70 ASP H 72 -1 N THR H 70 O TYR H 79 SHEET 1 AD4 4 GLY H 44 ILE H 51 0 SHEET 2 AD4 4 GLU H 33 THR H 40 -1 N THR H 40 O GLY H 44 SHEET 3 AD4 4 SER H 93 LEU H 95 -1 O LEU H 95 N GLU H 33 SHEET 4 AD4 4 PHE H 100A TRP H 103 -1 O ASP H 101 N ARG H 94 SHEET 1 AD5 4 THR L 5 THR L 7 0 SHEET 2 AD5 4 SER L 22 LYS L 24 -1 O SER L 22 N THR L 7 SHEET 3 AD5 4 ASP L 70 ILE L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AD5 4 PHE L 62 GLY L 66 -1 N SER L 65 O THR L 72 SHEET 1 AD6 3 LEU L 33 GLN L 38 0 SHEET 2 AD6 3 GLY L 84 GLN L 90 -1 O TYR L 87 N TYR L 36 SHEET 3 AD6 3 THR L 102 LEU L 104 -1 O THR L 102 N TYR L 86 SHEET 1 AD7 6 LEU m 11 VAL m 12 0 SHEET 2 AD7 6 THR m 126 VAL m 130 1 O THR m 129 N VAL m 12 SHEET 3 AD7 6 ALA m 91 TYR m 93 -1 N TYR m 93 O THR m 126 SHEET 4 AD7 6 TYR m 33 GLN m 39 -1 N GLN m 39 O ILE m 92 SHEET 5 AD7 6 GLU m 46 VAL m 51 -1 O GLU m 46 N ARG m 38 SHEET 6 AD7 6 THR m 57 ASN m 58 -1 O ASN m 58 N TYR m 50 SHEET 1 AD8 6 LEU m 11 VAL m 12 0 SHEET 2 AD8 6 THR m 126 VAL m 130 1 O THR m 129 N VAL m 12 SHEET 3 AD8 6 ALA m 91 TYR m 93 -1 N TYR m 93 O THR m 126 SHEET 4 AD8 6 TYR m 33 GLN m 39 -1 N GLN m 39 O ILE m 92 SHEET 5 AD8 6 ALA m 96 ARG m 102 -1 O ALA m 96 N SER m 35 SHEET 6 AD8 6 THR m 115 TYR m 118 -1 O TYR m 118 N LYS m 99 SHEET 1 AD9 2 LEU m 71 ASP m 72 0 SHEET 2 AD9 2 LEU m 77 VAL m 78 -1 O LEU m 77 N ASP m 72 SHEET 1 AE1 2 VAL n 11 VAL n 13 0 SHEET 2 AE1 2 LEU n 104 VAL n 106 1 O ILE n 105 N VAL n 11 SHEET 1 AE2 3 ALA n 19 THR n 22 0 SHEET 2 AE2 3 THR n 72 ILE n 75 -1 O ILE n 75 N ALA n 19 SHEET 3 AE2 3 PHE n 62 GLY n 64 -1 N SER n 63 O THR n 74 SHEET 1 AE3 2 ARG n 31 GLN n 38 0 SHEET 2 AE3 2 ASP n 85 ASP n 92 -1 O ASP n 85 N GLN n 38 SHEET 1 AE4 4 THR r 5 SER r 7 0 SHEET 2 AE4 4 ALA r 19 LYS r 24 -1 O LYS r 24 N THR r 5 SHEET 3 AE4 4 ASP r 69 ILE r 74 -1 O ILE r 74 N ALA r 19 SHEET 4 AE4 4 PHE r 61 SER r 66 -1 N VAL r 62 O THR r 73 SHEET 1 AE5 6 ILE r 10 LEU r 13 0 SHEET 2 AE5 6 SER r 97 VAL r 101 1 O GLU r 100 N LEU r 11 SHEET 3 AE5 6 VAL r 84 GLN r 89 -1 N TYR r 85 O SER r 97 SHEET 4 AE5 6 THR r 33 LYS r 37 -1 N THR r 33 O GLN r 88 SHEET 5 AE5 6 ARG r 44 TYR r 48 -1 O ARG r 44 N GLN r 36 SHEET 6 AE5 6 ARG r 52 ARG r 53 -1 O ARG r 52 N TYR r 48 SHEET 1 AE6 4 ILE r 10 LEU r 13 0 SHEET 2 AE6 4 SER r 97 VAL r 101 1 O GLU r 100 N LEU r 11 SHEET 3 AE6 4 VAL r 84 GLN r 89 -1 N TYR r 85 O SER r 97 SHEET 4 AE6 4 PHE r 92 PHE r 93 -1 O PHE r 92 N GLN r 89 SHEET 1 AE7 4 GLN q 3 VAL q 5 0 SHEET 2 AE7 4 SER q 17 SER q 25 -1 O SER q 25 N GLN q 3 SHEET 3 AE7 4 GLY q 76G SER q 82A-1 O GLY q 76G N ALA q 24 SHEET 4 AE7 4 VAL q 67 GLN q 72 -1 N SER q 68 O GLU q 81 SHEET 1 AE8 6 VAL q 10 ILE q 11 0 SHEET 2 AE8 6 THR q 107 VAL q 110 1 O VAL q 108 N VAL q 10 SHEET 3 AE8 6 ALA q 88 ARG q 95 -1 N TYR q 90 O THR q 107 SHEET 4 AE8 6 ILE q 34 ILE q 40 -1 N VAL q 37 O PHE q 91 SHEET 5 AE8 6 GLY q 44 ILE q 51 -1 O ILE q 51 N ILE q 34 SHEET 6 AE8 6 VAL q 57 TYR q 59 -1 O SER q 58 N TRP q 50 SHEET 1 AE9 4 VAL q 10 ILE q 11 0 SHEET 2 AE9 4 THR q 107 VAL q 110 1 O VAL q 108 N VAL q 10 SHEET 3 AE9 4 ALA q 88 ARG q 95 -1 N TYR q 90 O THR q 107 SHEET 4 AE9 4 TRP q 100F TRP q 103 -1 O TYR q 102 N ARG q 94 SHEET 1 AF1 2 TRP c 35 TYR c 40 0 SHEET 2 AF1 2 LEU c 494 THR c 499 -1 O ALA c 497 N THR c 37 SHEET 1 AF2 3 TRP c 45 ASP c 47 0 SHEET 2 AF2 3 TYR c 486 ILE c 491 -1 O LYS c 490 N LYS c 46 SHEET 3 AF2 3 PHE c 223 LYS c 227 -1 N ALA c 224 O VAL c 489 SHEET 1 AF3 3 VAL c 75 PRO c 76 0 SHEET 2 AF3 3 PHE c 53 SER c 56 1 N SER c 56 O VAL c 75 SHEET 3 AF3 3 ILE c 215 CYS c 218 -1 O HIS c 216 N ALA c 55 SHEET 1 AF4 2 ILE c 84 HIS c 85 0 SHEET 2 AF4 2 SER c 243 THR c 244 -1 O THR c 244 N ILE c 84 SHEET 1 AF5 2 GLU c 91 ASN c 94 0 SHEET 2 AF5 2 THR c 236 CYS c 239 -1 O GLY c 237 N PHE c 93 SHEET 1 AF6 3 GLN c 130 ASN c 133 0 SHEET 2 AF6 3 LYS c 155 THR c 162 -1 O SER c 158 N GLN c 130 SHEET 3 AF6 3 LYS c 169 PHE c 176 -1 O GLN c 170 N MET c 161 SHEET 1 AF7 2 VAL c 181 GLN c 183 0 SHEET 2 AF7 2 TYR c 191 LEU c 193 -1 O ARG c 192 N VAL c 182 SHEET 1 AF8 3 THR c 202 GLN c 203 0 SHEET 2 AF8 3 MET c 434 TYR c 435 1 O TYR c 435 N THR c 202 SHEET 3 AF8 3 ILE c 423 ILE c 424 -1 N ILE c 424 O MET c 434 SHEET 1 AF9 5 MET c 271 ARG c 273 0 SHEET 2 AF9 5 ILE c 284 ARG c 298 -1 O GLN c 287 N MET c 271 SHEET 3 AF9 5 ILE c 443 ARG c 456 -1 O THR c 450 N PHE c 288 SHEET 4 AF9 5 THR c 465 PRO c 470 -1 O ARG c 469 N THR c 455 SHEET 5 AF9 5 ILE c 358 PHE c 361 1 N ARG c 360 O PHE c 468 SHEET 1 AG1 6 MET c 271 ARG c 273 0 SHEET 2 AG1 6 ILE c 284 ARG c 298 -1 O GLN c 287 N MET c 271 SHEET 3 AG1 6 HIS c 330 SER c 334 -1 O ASN c 332 N ASN c 295 SHEET 4 AG1 6 SER c 413 ILE c 420 -1 O ILE c 414 N VAL c 333 SHEET 5 AG1 6 PHE c 382 CYS c 385 -1 N TYR c 384 O ARG c 419 SHEET 6 AG1 6 HIS c 374 ASN c 377 -1 N HIS c 374 O CYS c 385 SHEET 1 AG2 2 ARG c 304 GLY c 312 0 SHEET 2 AG2 2 GLN c 315 THR c 320 -1 O PHE c 317 N ILE c 307 SHEET 1 AG3 6 LEU 7 11 VAL 7 12 0 SHEET 2 AG3 6 THR 7 126 VAL 7 130 1 O THR 7 129 N VAL 7 12 SHEET 3 AG3 6 ALA 7 91 TYR 7 93 -1 N TYR 7 93 O THR 7 126 SHEET 4 AG3 6 TYR 7 33 GLN 7 39 -1 N GLN 7 39 O ILE 7 92 SHEET 5 AG3 6 GLU 7 46 VAL 7 51 -1 O GLU 7 46 N ARG 7 38 SHEET 6 AG3 6 THR 7 57 ASN 7 58 -1 O ASN 7 58 N TYR 7 50 SHEET 1 AG4 6 LEU 7 11 VAL 7 12 0 SHEET 2 AG4 6 THR 7 126 VAL 7 130 1 O THR 7 129 N VAL 7 12 SHEET 3 AG4 6 ALA 7 91 TYR 7 93 -1 N TYR 7 93 O THR 7 126 SHEET 4 AG4 6 TYR 7 33 GLN 7 39 -1 N GLN 7 39 O ILE 7 92 SHEET 5 AG4 6 ALA 7 96 ARG 7 102 -1 O ALA 7 96 N SER 7 35 SHEET 6 AG4 6 THR 7 115 TYR 7 118 -1 O TYR 7 118 N LYS 7 99 SHEET 1 AG5 2 LEU 7 71 ASP 7 72 0 SHEET 2 AG5 2 LEU 7 77 VAL 7 78 -1 O LEU 7 77 N ASP 7 72 SHEET 1 AG6 2 VAL 8 11 VAL 8 13 0 SHEET 2 AG6 2 LEU 8 104 VAL 8 106 1 O ILE 8 105 N VAL 8 11 SHEET 1 AG7 3 ALA 8 19 THR 8 22 0 SHEET 2 AG7 3 THR 8 72 ILE 8 75 -1 O ILE 8 75 N ALA 8 19 SHEET 3 AG7 3 PHE 8 62 GLY 8 64 -1 N SER 8 63 O THR 8 74 SHEET 1 AG8 2 ARG 8 31 GLN 8 38 0 SHEET 2 AG8 2 ASP 8 85 ASP 8 92 -1 O ASP 8 85 N GLN 8 38 SHEET 1 AG9 4 THR 6 5 SER 6 7 0 SHEET 2 AG9 4 ALA 6 19 LYS 6 24 -1 O LYS 6 24 N THR 6 5 SHEET 3 AG9 4 ASP 6 69 ILE 6 74 -1 O ILE 6 74 N ALA 6 19 SHEET 4 AG9 4 PHE 6 61 SER 6 66 -1 N VAL 6 62 O THR 6 73 SHEET 1 AH1 6 ILE 6 10 LEU 6 13 0 SHEET 2 AH1 6 SER 6 97 VAL 6 101 1 O GLU 6 100 N LEU 6 11 SHEET 3 AH1 6 VAL 6 84 GLN 6 89 -1 N TYR 6 85 O SER 6 97 SHEET 4 AH1 6 THR 6 33 LYS 6 37 -1 N THR 6 33 O GLN 6 88 SHEET 5 AH1 6 ARG 6 44 TYR 6 48 -1 O ARG 6 44 N GLN 6 36 SHEET 6 AH1 6 ARG 6 52 ARG 6 53 -1 O ARG 6 52 N TYR 6 48 SHEET 1 AH2 4 ILE 6 10 LEU 6 13 0 SHEET 2 AH2 4 SER 6 97 VAL 6 101 1 O GLU 6 100 N LEU 6 11 SHEET 3 AH2 4 VAL 6 84 GLN 6 89 -1 N TYR 6 85 O SER 6 97 SHEET 4 AH2 4 PHE 6 92 PHE 6 93 -1 O PHE 6 92 N GLN 6 89 SHEET 1 AH3 4 GLN 5 3 VAL 5 5 0 SHEET 2 AH3 4 SER 5 17 SER 5 25 -1 O SER 5 25 N GLN 5 3 SHEET 3 AH3 4 GLY 5 76G SER 5 82A-1 O GLY 5 76G N ALA 5 24 SHEET 4 AH3 4 VAL 5 67 GLN 5 72 -1 N SER 5 68 O GLU 5 81 SHEET 1 AH4 6 VAL 5 10 ILE 5 11 0 SHEET 2 AH4 6 THR 5 107 VAL 5 110 1 O VAL 5 108 N VAL 5 10 SHEET 3 AH4 6 ALA 5 88 ARG 5 95 -1 N TYR 5 90 O THR 5 107 SHEET 4 AH4 6 ILE 5 34 ILE 5 40 -1 N VAL 5 37 O PHE 5 91 SHEET 5 AH4 6 GLY 5 44 ILE 5 51 -1 O ILE 5 51 N ILE 5 34 SHEET 6 AH4 6 VAL 5 57 TYR 5 59 -1 O SER 5 58 N TRP 5 50 SHEET 1 AH5 4 VAL 5 10 ILE 5 11 0 SHEET 2 AH5 4 THR 5 107 VAL 5 110 1 O VAL 5 108 N VAL 5 10 SHEET 3 AH5 4 ALA 5 88 ARG 5 95 -1 N TYR 5 90 O THR 5 107 SHEET 4 AH5 4 TRP 5 100F TRP 5 103 -1 O TYR 5 102 N ARG 5 94 SHEET 1 AH6 2 TRP 2 35 TYR 2 40 0 SHEET 2 AH6 2 LEU 2 494 THR 2 499 -1 O ALA 2 497 N THR 2 37 SHEET 1 AH7 3 TRP 2 45 ASP 2 47 0 SHEET 2 AH7 3 TYR 2 486 ILE 2 491 -1 O LYS 2 490 N LYS 2 46 SHEET 3 AH7 3 PHE 2 223 LYS 2 227 -1 N ALA 2 224 O VAL 2 489 SHEET 1 AH8 3 VAL 2 75 PRO 2 76 0 SHEET 2 AH8 3 PHE 2 53 SER 2 56 1 N SER 2 56 O VAL 2 75 SHEET 3 AH8 3 ILE 2 215 CYS 2 218 -1 O HIS 2 216 N ALA 2 55 SHEET 1 AH9 2 ILE 2 84 HIS 2 85 0 SHEET 2 AH9 2 SER 2 243 THR 2 244 -1 O THR 2 244 N ILE 2 84 SHEET 1 AI1 2 GLU 2 91 ASN 2 94 0 SHEET 2 AI1 2 THR 2 236 CYS 2 239 -1 O GLY 2 237 N PHE 2 93 SHEET 1 AI2 3 GLN 2 130 ASN 2 133 0 SHEET 2 AI2 3 LYS 2 155 THR 2 162 -1 O SER 2 158 N GLN 2 130 SHEET 3 AI2 3 LYS 2 169 PHE 2 176 -1 O GLN 2 170 N MET 2 161 SHEET 1 AI3 2 VAL 2 181 GLN 2 183 0 SHEET 2 AI3 2 TYR 2 191 LEU 2 193 -1 O ARG 2 192 N VAL 2 182 SHEET 1 AI4 3 THR 2 202 GLN 2 203 0 SHEET 2 AI4 3 MET 2 434 TYR 2 435 1 O TYR 2 435 N THR 2 202 SHEET 3 AI4 3 ILE 2 423 ILE 2 424 -1 N ILE 2 424 O MET 2 434 SHEET 1 AI5 5 MET 2 271 ARG 2 273 0 SHEET 2 AI5 5 ILE 2 284 ARG 2 298 -1 O GLN 2 287 N MET 2 271 SHEET 3 AI5 5 ILE 2 443 ARG 2 456 -1 O THR 2 450 N PHE 2 288 SHEET 4 AI5 5 THR 2 465 PRO 2 470 -1 O ARG 2 469 N THR 2 455 SHEET 5 AI5 5 ILE 2 358 PHE 2 361 1 N ARG 2 360 O PHE 2 468 SHEET 1 AI6 6 MET 2 271 ARG 2 273 0 SHEET 2 AI6 6 ILE 2 284 ARG 2 298 -1 O GLN 2 287 N MET 2 271 SHEET 3 AI6 6 HIS 2 330 SER 2 334 -1 O ASN 2 332 N ASN 2 295 SHEET 4 AI6 6 SER 2 413 ILE 2 420 -1 O ILE 2 414 N VAL 2 333 SHEET 5 AI6 6 PHE 2 382 CYS 2 385 -1 N TYR 2 384 O ARG 2 419 SHEET 6 AI6 6 HIS 2 374 ASN 2 377 -1 N HIS 2 374 O CYS 2 385 SHEET 1 AI7 2 ARG 2 304 GLY 2 312 0 SHEET 2 AI7 2 GLN 2 315 THR 2 320 -1 O PHE 2 317 N ILE 2 307 SHEET 1 AI8 2 ASP 3 10 LEU 3 11 0 SHEET 2 AI8 2 VAL 3 109 THR 3 110 1 O THR 3 110 N ASP 3 10 SHEET 1 AI9 3 SER 3 21 LYS 3 23 0 SHEET 2 AI9 3 THR 3 77 TYR 3 79 -1 O VAL 3 78 N CYS 3 22 SHEET 3 AI9 3 THR 3 70 ASP 3 72 -1 N THR 3 70 O TYR 3 79 SHEET 1 AJ1 4 GLY 3 44 ILE 3 51 0 SHEET 2 AJ1 4 GLU 3 33 THR 3 40 -1 N THR 3 40 O GLY 3 44 SHEET 3 AJ1 4 SER 3 93 LEU 3 95 -1 O LEU 3 95 N GLU 3 33 SHEET 4 AJ1 4 PHE 3 100A TRP 3 103 -1 O ASP 3 101 N ARG 3 94 SHEET 1 AJ2 4 THR 4 5 THR 4 7 0 SHEET 2 AJ2 4 SER 4 22 LYS 4 24 -1 O SER 4 22 N THR 4 7 SHEET 3 AJ2 4 ASP 4 70 ILE 4 75 -1 O PHE 4 71 N CYS 4 23 SHEET 4 AJ2 4 PHE 4 62 GLY 4 66 -1 N SER 4 65 O THR 4 72 SHEET 1 AJ3 3 LEU 4 33 GLN 4 38 0 SHEET 2 AJ3 3 GLY 4 84 GLN 4 90 -1 O TYR 4 87 N TYR 4 36 SHEET 3 AJ3 3 THR 4 102 LEU 4 104 -1 O THR 4 102 N TYR 4 86 SSBOND 1 CYS h 22 CYS h 92 1555 1555 2.13 SSBOND 2 CYS l 23 CYS l 88 1555 1555 2.09 SSBOND 3 CYS M 22 CYS M 95 1555 1555 2.19 SSBOND 4 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 5 CYS R 23 CYS R 87 1555 1555 2.05 SSBOND 6 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 7 CYS Q 98 CYS Q 100A 1555 1555 2.16 SSBOND 8 CYS D 598 CYS D 604 1555 1555 2.02 SSBOND 9 CYS D 605 CYS C 501 1555 1555 2.03 SSBOND 10 CYS C 54 CYS C 74 1555 1555 2.34 SSBOND 11 CYS C 119 CYS C 205 1555 1555 2.03 SSBOND 12 CYS C 126 CYS C 196 1555 1555 2.02 SSBOND 13 CYS C 131 CYS C 157 1555 1555 2.03 SSBOND 14 CYS C 201 CYS C 433 1555 1555 2.02 SSBOND 15 CYS C 218 CYS C 247 1555 1555 2.03 SSBOND 16 CYS C 228 CYS C 239 1555 1555 2.04 SSBOND 17 CYS C 296 CYS C 331 1555 1555 2.03 SSBOND 18 CYS C 378 CYS C 445 1555 1555 2.03 SSBOND 19 CYS C 385 CYS C 418 1555 1555 2.03 SSBOND 20 CYS H 22 CYS H 92 1555 1555 2.13 SSBOND 21 CYS L 23 CYS L 88 1555 1555 2.09 SSBOND 22 CYS m 22 CYS m 95 1555 1555 2.25 SSBOND 23 CYS n 23 CYS n 88 1555 1555 2.03 SSBOND 24 CYS r 23 CYS r 87 1555 1555 2.05 SSBOND 25 CYS q 22 CYS q 92 1555 1555 2.03 SSBOND 26 CYS q 98 CYS q 100A 1555 1555 2.16 SSBOND 27 CYS d 598 CYS d 604 1555 1555 2.02 SSBOND 28 CYS d 605 CYS c 501 1555 1555 2.03 SSBOND 29 CYS c 54 CYS c 74 1555 1555 2.27 SSBOND 30 CYS c 119 CYS c 205 1555 1555 2.03 SSBOND 31 CYS c 126 CYS c 196 1555 1555 2.02 SSBOND 32 CYS c 131 CYS c 157 1555 1555 2.03 SSBOND 33 CYS c 201 CYS c 433 1555 1555 2.02 SSBOND 34 CYS c 218 CYS c 247 1555 1555 2.03 SSBOND 35 CYS c 228 CYS c 239 1555 1555 2.04 SSBOND 36 CYS c 296 CYS c 331 1555 1555 2.02 SSBOND 37 CYS c 378 CYS c 445 1555 1555 2.03 SSBOND 38 CYS c 385 CYS c 418 1555 1555 2.03 SSBOND 39 CYS 7 22 CYS 7 95 1555 1555 2.40 SSBOND 40 CYS 8 23 CYS 8 88 1555 1555 2.03 SSBOND 41 CYS 6 23 CYS 6 87 1555 1555 2.05 SSBOND 42 CYS 5 22 CYS 5 92 1555 1555 2.03 SSBOND 43 CYS 5 98 CYS 5 100A 1555 1555 2.18 SSBOND 44 CYS 1 598 CYS 1 604 1555 1555 2.02 SSBOND 45 CYS 1 605 CYS 2 501 1555 1555 2.03 SSBOND 46 CYS 2 54 CYS 2 74 1555 1555 2.42 SSBOND 47 CYS 2 119 CYS 2 205 1555 1555 2.03 SSBOND 48 CYS 2 126 CYS 2 196 1555 1555 2.02 SSBOND 49 CYS 2 131 CYS 2 157 1555 1555 2.03 SSBOND 50 CYS 2 201 CYS 2 433 1555 1555 2.02 SSBOND 51 CYS 2 218 CYS 2 247 1555 1555 2.03 SSBOND 52 CYS 2 228 CYS 2 239 1555 1555 2.04 SSBOND 53 CYS 2 296 CYS 2 331 1555 1555 2.03 SSBOND 54 CYS 2 378 CYS 2 445 1555 1555 2.03 SSBOND 55 CYS 2 385 CYS 2 418 1555 1555 2.03 SSBOND 56 CYS 3 22 CYS 3 92 1555 1555 2.13 SSBOND 57 CYS 4 23 CYS 4 88 1555 1555 2.09 LINK ND2 ASN D 618 C1 NAG D 701 1555 1555 1.44 LINK ND2 ASN D 637 C1 NAG D 702 1555 1555 1.42 LINK ND2 ASN C 88 C1 NAG C 601 1555 1555 1.45 LINK ND2 ASN C 133 C1 NAG C 603 1555 1555 1.41 LINK ND2 ASN C 137 C1 NAG C 605 1555 1555 1.41 LINK OD1 ASP C 140 C6 NAG C 604 1555 1555 1.38 LINK ND2 ASN C 156 C1 NAG C 609 1555 1555 1.41 LINK ND2 ASN C 160 C1 NAG C 616 1555 1555 1.48 LINK ND2 ASN C 197 C1 NAG C 624 1555 1555 1.42 LINK ND2 ASN C 234 C1 NAG C 626 1555 1555 1.41 LINK ND2 ASN C 262 C1 NAG C 631 1555 1555 1.55 LINK ND2 ASN C 295 C1 NAG C 639 1555 1555 1.40 LINK ND2 ASN C 301 C1 NAG C 641 1555 1555 1.45 LINK ND2 ASN C 332 C1 NAG C 644 1555 1555 1.41 LINK ND2 ASN C 339 C1 NAG C 653 1555 1555 1.44 LINK ND2 ASN C 355 C1 NAG C 654 1555 1555 1.43 LINK ND2 ASN C 363 C1 NAG C 655 1555 1555 1.42 LINK ND2 ASN C 386 C1 NAG C 658 1555 1555 1.44 LINK ND2 ASN C 392 C1 NAG C 662 1555 1555 1.43 LINK ND2 ASN C 448 C1 NAG C 665 1555 1555 1.42 LINK ND2 ASN d 618 C1 NAG d 701 1555 1555 1.44 LINK ND2 ASN d 637 C1 NAG d 702 1555 1555 1.42 LINK ND2 ASN c 88 C1 NAG c 601 1555 1555 1.45 LINK ND2 ASN c 133 C1 NAG c 603 1555 1555 1.41 LINK ND2 ASN c 137 C1 NAG c 605 1555 1555 1.41 LINK OD1 ASP c 140 C6 NAG c 604 1555 1555 1.38 LINK ND2 ASN c 156 C1 NAG c 609 1555 1555 1.41 LINK ND2 ASN c 160 C1 NAG c 616 1555 1555 1.48 LINK ND2 ASN c 197 C1 NAG c 624 1555 1555 1.42 LINK ND2 ASN c 234 C1 NAG c 626 1555 1555 1.41 LINK ND2 ASN c 262 C1 NAG c 631 1555 1555 1.56 LINK ND2 ASN c 295 C1 NAG c 639 1555 1555 1.40 LINK ND2 ASN c 301 C1 NAG c 641 1555 1555 1.45 LINK ND2 ASN c 332 C1 NAG c 644 1555 1555 1.41 LINK ND2 ASN c 339 C1 NAG c 653 1555 1555 1.44 LINK ND2 ASN c 355 C1 NAG c 654 1555 1555 1.43 LINK ND2 ASN c 363 C1 NAG c 655 1555 1555 1.42 LINK ND2 ASN c 386 C1 NAG c 658 1555 1555 1.44 LINK ND2 ASN c 392 C1 NAG c 662 1555 1555 1.43 LINK ND2 ASN c 448 C1 NAG c 665 1555 1555 1.42 LINK ND2 ASN 1 618 C1 NAG 1 701 1555 1555 1.44 LINK ND2 ASN 1 637 C1 NAG 1 702 1555 1555 1.42 LINK ND2 ASN 2 88 C1 NAG 2 601 1555 1555 1.45 LINK ND2 ASN 2 133 C1 NAG 2 603 1555 1555 1.41 LINK ND2 ASN 2 137 C1 NAG 2 605 1555 1555 1.41 LINK OD1 ASP 2 140 C6 NAG 2 604 1555 1555 1.38 LINK ND2 ASN 2 156 C1 NAG 2 609 1555 1555 1.41 LINK ND2 ASN 2 160 C1 NAG 2 616 1555 1555 1.48 LINK ND2 ASN 2 197 C1 NAG 2 624 1555 1555 1.42 LINK ND2 ASN 2 234 C1 NAG 2 626 1555 1555 1.41 LINK ND2 ASN 2 262 C1 NAG 2 631 1555 1555 1.56 LINK ND2 ASN 2 295 C1 NAG 2 639 1555 1555 1.39 LINK ND2 ASN 2 301 C1 NAG 2 641 1555 1555 1.45 LINK ND2 ASN 2 332 C1 NAG 2 644 1555 1555 1.41 LINK ND2 ASN 2 339 C1 NAG 2 653 1555 1555 1.44 LINK ND2 ASN 2 355 C1 NAG 2 654 1555 1555 1.43 LINK ND2 ASN 2 363 C1 NAG 2 655 1555 1555 1.42 LINK ND2 ASN 2 386 C1 NAG 2 658 1555 1555 1.44 LINK ND2 ASN 2 392 C1 NAG 2 662 1555 1555 1.43 LINK ND2 ASN 2 448 C1 NAG 2 665 1555 1555 1.42 LINK O4 NAG D 702 C1 NAG D 703 1555 1555 1.44 LINK O4 NAG D 703 C1 BMA D 704 1555 1555 1.45 LINK O4 NAG D 705 C1 NAG D 706 1555 1555 1.45 LINK O4 NAG D 706 C1 BMA D 707 1555 1555 1.44 LINK O4 NAG C 601 C1 NAG C 602 1555 1555 1.45 LINK O4 NAG C 603 C1 NAG C 604 1555 1555 1.46 LINK O4 NAG C 605 C1 NAG C 606 1555 1555 1.44 LINK O4 NAG C 606 C1 BMA C 607 1555 1555 1.45 LINK O3 BMA C 607 C1 MAN C 608 1555 1555 1.45 LINK O4 NAG C 609 C1 NAG C 610 1555 1555 1.45 LINK O4 NAG C 610 C1 BMA C 611 1555 1555 1.45 LINK O3 BMA C 611 C1 MAN C 612 1555 1555 1.44 LINK O6 BMA C 611 C1 MAN C 613 1555 1555 1.44 LINK O2 MAN C 612 C1 MAN C 614 1555 1555 1.44 LINK O4 NAG C 616 C1 NAG C 617 1555 1555 1.44 LINK O4 NAG C 617 C1 BMA C 618 1555 1555 1.45 LINK O3 BMA C 618 C1 MAN C 619 1555 1555 1.46 LINK O6 BMA C 618 C1 MAN C 620 1555 1555 1.44 LINK O2 MAN C 619 C1 MAN C 621 1555 1555 1.44 LINK O3 MAN C 620 C1 MAN C 622 1555 1555 1.45 LINK O2 MAN C 621 C1 MAN C 623 1555 1555 1.45 LINK O4 NAG C 624 C1 NAG C 625 1555 1555 1.44 LINK O4 NAG C 626 C1 NAG C 627 1555 1555 1.46 LINK O4 NAG C 627 C1 BMA C 628 1555 1555 1.43 LINK O3 BMA C 628 C1 MAN C 629 1555 1555 1.45 LINK O6 BMA C 628 C1 MAN C 630 1555 1555 1.45 LINK O4 NAG C 631 C1 NAG C 632 1555 1555 1.45 LINK O4 NAG C 632 C1 BMA C 633 1555 1555 1.44 LINK O3 BMA C 633 C1 MAN C 634 1555 1555 1.44 LINK O6 BMA C 633 C1 MAN C 635 1555 1555 1.46 LINK O2 MAN C 634 C1 MAN C 636 1555 1555 1.45 LINK O3 MAN C 635 C1 MAN C 637 1555 1555 1.45 LINK O2 MAN C 637 C1 MAN C 638 1555 1555 1.44 LINK O4 NAG C 639 C1 NAG C 640 1555 1555 1.45 LINK O4 NAG C 641 C1 NAG C 642 1555 1555 1.43 LINK O4 NAG C 642 C1 BMA C 643 1555 1555 1.44 LINK O4 NAG C 644 C1 NAG C 645 1555 1555 1.44 LINK O4 NAG C 645 C1 BMA C 646 1555 1555 1.44 LINK O3 BMA C 646 C1 MAN C 647 1555 1555 1.45 LINK O6 BMA C 646 C1 MAN C 648 1555 1555 1.44 LINK O2 MAN C 647 C1 MAN C 649 1555 1555 1.44 LINK O3 MAN C 648 C1 MAN C 650 1555 1555 1.44 LINK O6 MAN C 648 C1 MAN C 651 1555 1555 1.45 LINK O2 MAN C 650 C1 MAN C 652 1555 1555 1.44 LINK O4 NAG C 655 C1 NAG C 656 1555 1555 1.45 LINK O4 NAG C 656 C1 BMA C 657 1555 1555 1.46 LINK O4 NAG C 658 C1 NAG C 659 1555 1555 1.44 LINK O4 NAG C 659 C1 BMA C 660 1555 1555 1.45 LINK O6 BMA C 660 C1 MAN C 661 1555 1555 1.44 LINK O4 NAG C 662 C1 NAG C 663 1555 1555 1.45 LINK O4 NAG C 663 C1 BMA C 664 1555 1555 1.45 LINK O4 NAG C 665 C1 NAG C 666 1555 1555 1.44 LINK O4 NAG C 666 C1 BMA C 667 1555 1555 1.45 LINK O4 NAG d 702 C1 NAG d 703 1555 1555 1.44 LINK O4 NAG d 703 C1 BMA d 704 1555 1555 1.45 LINK O4 NAG d 705 C1 NAG d 706 1555 1555 1.45 LINK O4 NAG d 706 C1 BMA d 707 1555 1555 1.44 LINK O4 NAG c 601 C1 NAG c 602 1555 1555 1.45 LINK O4 NAG c 603 C1 NAG c 604 1555 1555 1.46 LINK O4 NAG c 605 C1 NAG c 606 1555 1555 1.44 LINK O4 NAG c 606 C1 BMA c 607 1555 1555 1.45 LINK O3 BMA c 607 C1 MAN c 608 1555 1555 1.45 LINK O4 NAG c 609 C1 NAG c 610 1555 1555 1.45 LINK O4 NAG c 610 C1 BMA c 611 1555 1555 1.45 LINK O3 BMA c 611 C1 MAN c 612 1555 1555 1.44 LINK O6 BMA c 611 C1 MAN c 613 1555 1555 1.44 LINK O2 MAN c 612 C1 MAN c 614 1555 1555 1.44 LINK O4 NAG c 616 C1 NAG c 617 1555 1555 1.44 LINK O4 NAG c 617 C1 BMA c 618 1555 1555 1.45 LINK O3 BMA c 618 C1 MAN c 619 1555 1555 1.46 LINK O6 BMA c 618 C1 MAN c 620 1555 1555 1.45 LINK O2 MAN c 619 C1 MAN c 621 1555 1555 1.44 LINK O3 MAN c 620 C1 MAN c 622 1555 1555 1.45 LINK O2 MAN c 621 C1 MAN c 623 1555 1555 1.45 LINK O4 NAG c 624 C1 NAG c 625 1555 1555 1.44 LINK O4 NAG c 626 C1 NAG c 627 1555 1555 1.46 LINK O4 NAG c 627 C1 BMA c 628 1555 1555 1.43 LINK O3 BMA c 628 C1 MAN c 629 1555 1555 1.45 LINK O6 BMA c 628 C1 MAN c 630 1555 1555 1.45 LINK O4 NAG c 631 C1 NAG c 632 1555 1555 1.45 LINK O4 NAG c 632 C1 BMA c 633 1555 1555 1.44 LINK O3 BMA c 633 C1 MAN c 634 1555 1555 1.44 LINK O6 BMA c 633 C1 MAN c 635 1555 1555 1.46 LINK O2 MAN c 634 C1 MAN c 636 1555 1555 1.45 LINK O3 MAN c 635 C1 MAN c 637 1555 1555 1.45 LINK O2 MAN c 637 C1 MAN c 638 1555 1555 1.44 LINK O4 NAG c 639 C1 NAG c 640 1555 1555 1.45 LINK O4 NAG c 641 C1 NAG c 642 1555 1555 1.43 LINK O4 NAG c 642 C1 BMA c 643 1555 1555 1.44 LINK O4 NAG c 644 C1 NAG c 645 1555 1555 1.44 LINK O4 NAG c 645 C1 BMA c 646 1555 1555 1.44 LINK O3 BMA c 646 C1 MAN c 647 1555 1555 1.45 LINK O6 BMA c 646 C1 MAN c 648 1555 1555 1.44 LINK O2 MAN c 647 C1 MAN c 649 1555 1555 1.44 LINK O3 MAN c 648 C1 MAN c 650 1555 1555 1.44 LINK O6 MAN c 648 C1 MAN c 651 1555 1555 1.45 LINK O2 MAN c 650 C1 MAN c 652 1555 1555 1.44 LINK O4 NAG c 655 C1 NAG c 656 1555 1555 1.45 LINK O4 NAG c 656 C1 BMA c 657 1555 1555 1.46 LINK O4 NAG c 658 C1 NAG c 659 1555 1555 1.44 LINK O4 NAG c 659 C1 BMA c 660 1555 1555 1.45 LINK O6 BMA c 660 C1 MAN c 661 1555 1555 1.44 LINK O4 NAG c 662 C1 NAG c 663 1555 1555 1.45 LINK O4 NAG c 663 C1 BMA c 664 1555 1555 1.45 LINK O4 NAG c 665 C1 NAG c 666 1555 1555 1.44 LINK O4 NAG c 666 C1 BMA c 667 1555 1555 1.45 LINK O4 NAG 1 702 C1 NAG 1 703 1555 1555 1.44 LINK O4 NAG 1 703 C1 BMA 1 704 1555 1555 1.45 LINK O4 NAG 1 705 C1 NAG 1 706 1555 1555 1.45 LINK O4 NAG 1 706 C1 BMA 1 707 1555 1555 1.44 LINK O4 NAG 2 601 C1 NAG 2 602 1555 1555 1.45 LINK O4 NAG 2 603 C1 NAG 2 604 1555 1555 1.46 LINK O4 NAG 2 605 C1 NAG 2 606 1555 1555 1.44 LINK O4 NAG 2 606 C1 BMA 2 607 1555 1555 1.45 LINK O3 BMA 2 607 C1 MAN 2 608 1555 1555 1.45 LINK O4 NAG 2 609 C1 NAG 2 610 1555 1555 1.45 LINK O4 NAG 2 610 C1 BMA 2 611 1555 1555 1.45 LINK O3 BMA 2 611 C1 MAN 2 612 1555 1555 1.44 LINK O6 BMA 2 611 C1 MAN 2 613 1555 1555 1.44 LINK O2 MAN 2 612 C1 MAN 2 614 1555 1555 1.44 LINK O4 NAG 2 616 C1 NAG 2 617 1555 1555 1.44 LINK O4 NAG 2 617 C1 BMA 2 618 1555 1555 1.45 LINK O3 BMA 2 618 C1 MAN 2 619 1555 1555 1.46 LINK O6 BMA 2 618 C1 MAN 2 620 1555 1555 1.45 LINK O2 MAN 2 619 C1 MAN 2 621 1555 1555 1.44 LINK O3 MAN 2 620 C1 MAN 2 622 1555 1555 1.45 LINK O2 MAN 2 621 C1 MAN 2 623 1555 1555 1.45 LINK O4 NAG 2 624 C1 NAG 2 625 1555 1555 1.44 LINK O4 NAG 2 626 C1 NAG 2 627 1555 1555 1.46 LINK O4 NAG 2 627 C1 BMA 2 628 1555 1555 1.43 LINK O3 BMA 2 628 C1 MAN 2 629 1555 1555 1.45 LINK O6 BMA 2 628 C1 MAN 2 630 1555 1555 1.45 LINK O4 NAG 2 631 C1 NAG 2 632 1555 1555 1.45 LINK O4 NAG 2 632 C1 BMA 2 633 1555 1555 1.44 LINK O3 BMA 2 633 C1 MAN 2 634 1555 1555 1.44 LINK O6 BMA 2 633 C1 MAN 2 635 1555 1555 1.46 LINK O2 MAN 2 634 C1 MAN 2 636 1555 1555 1.45 LINK O3 MAN 2 635 C1 MAN 2 637 1555 1555 1.45 LINK O2 MAN 2 637 C1 MAN 2 638 1555 1555 1.44 LINK O4 NAG 2 639 C1 NAG 2 640 1555 1555 1.45 LINK O4 NAG 2 641 C1 NAG 2 642 1555 1555 1.43 LINK O4 NAG 2 642 C1 BMA 2 643 1555 1555 1.44 LINK O4 NAG 2 644 C1 NAG 2 645 1555 1555 1.44 LINK O4 NAG 2 645 C1 BMA 2 646 1555 1555 1.44 LINK O3 BMA 2 646 C1 MAN 2 647 1555 1555 1.45 LINK O6 BMA 2 646 C1 MAN 2 648 1555 1555 1.44 LINK O2 MAN 2 647 C1 MAN 2 649 1555 1555 1.44 LINK O3 MAN 2 648 C1 MAN 2 650 1555 1555 1.44 LINK O6 MAN 2 648 C1 MAN 2 651 1555 1555 1.45 LINK O2 MAN 2 650 C1 MAN 2 652 1555 1555 1.44 LINK O4 NAG 2 655 C1 NAG 2 656 1555 1555 1.45 LINK O4 NAG 2 656 C1 BMA 2 657 1555 1555 1.46 LINK O4 NAG 2 658 C1 NAG 2 659 1555 1555 1.44 LINK O4 NAG 2 659 C1 BMA 2 660 1555 1555 1.45 LINK O6 BMA 2 660 C1 MAN 2 661 1555 1555 1.44 LINK O4 NAG 2 662 C1 NAG 2 663 1555 1555 1.45 LINK O4 NAG 2 663 C1 BMA 2 664 1555 1555 1.45 LINK O4 NAG 2 665 C1 NAG 2 666 1555 1555 1.44 LINK O4 NAG 2 666 C1 BMA 2 667 1555 1555 1.45 CISPEP 1 THR l 7 PRO l 8 0 -4.63 CISPEP 2 LEU l 94 PRO l 95 0 -5.17 CISPEP 3 SER R 7 PRO R 8 0 3.31 CISPEP 4 THR L 7 PRO L 8 0 -4.55 CISPEP 5 LEU L 94 PRO L 95 0 -5.12 CISPEP 6 SER r 7 PRO r 8 0 3.30 CISPEP 7 SER 6 7 PRO 6 8 0 3.35 CISPEP 8 THR 4 7 PRO 4 8 0 -4.59 CISPEP 9 LEU 4 94 PRO 4 95 0 -5.15 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.002457 0.000000 0.000000 0.00000 SCALE2 0.000000 0.002457 0.000000 0.00000 SCALE3 0.000000 0.000000 0.002457 0.00000