HEADER IMMUNE SYSTEM 10-DEC-18 6NC3 TITLE AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING TITLE 2 ANTIBODY VRC34 FRAGMENT ANTIGEN BINDING COMPND MOL_ID: 1; COMPND 2 MOLECULE: HIV-1 ENV AMC011 V4.2 SOSIP GP120; COMPND 3 CHAIN: A, C, D, E, F, G; COMPND 4 ENGINEERED: YES; COMPND 5 MUTATION: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: HIV-1 ENV AMC011 V4.2 SOSIP GP41; COMPND 8 CHAIN: B, I, J, K, M, N; COMPND 9 ENGINEERED: YES; COMPND 10 MUTATION: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: MONOCLONAL ANTIBODY VRC34.01 FRAGMENT ANTIGEN BINDING HEAVY COMPND 13 CHAIN; COMPND 14 CHAIN: H, O, P, Q, R, S; COMPND 15 ENGINEERED: YES; COMPND 16 MOL_ID: 4; COMPND 17 MOLECULE: MONOCLONAL ANTIBODY VRC34.01 FRAGMENT ANTIGEN BINDING LIGHT COMPND 18 CHAIN; COMPND 19 CHAIN: L, T, U, V, W, X; COMPND 20 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 EXPRESSION_SYSTEM_CELL_LINE: HEK293F; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 10 ORGANISM_TAXID: 11676; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 14 MOL_ID: 3; SOURCE 15 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 16 ORGANISM_COMMON: HUMAN; SOURCE 17 ORGANISM_TAXID: 9606; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM_CELL_LINE: HEK293F; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 29 EXPRESSION_SYSTEM_CELL: HEK293F KEYWDS HIV-1 ENV, SOSIP, TRIMER, BROADLY NEUTRALIZING ANTIBODY, FUSION KEYWDS 2 PEPTIDE, VIRAL PROTEIN, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR C.A.COTTRELL,G.OZOROWSKI,J.L.TORRES,A.B.WARD JRNL AUTH M.YUAN,C.A.COTTRELL,G.OZOROWSKI,M.J.VAN GILS,S.KUMAR,N.C.WU, JRNL AUTH 2 A.SARKAR,J.L.TORRES,N.DE VAL,J.COPPS,J.P.MOORE,R.W.SANDERS, JRNL AUTH 3 A.B.WARD,I.A.WILSON JRNL TITL CONFORMATIONAL PLASTICITY IN THE HIV-1 FUSION PEPTIDE JRNL TITL 2 FACILITATES RECOGNITION BY BROADLY NEUTRALIZING ANTIBODIES. JRNL REF CELL HOST MICROBE V. 25 873 2019 JRNL REFN ESSN 1934-6069 JRNL PMID 31194940 JRNL DOI 10.1016/J.CHOM.2019.04.011 REMARK 2 REMARK 2 RESOLUTION. 4.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : DOG PICKER, LEGINON, GCTF, ROSETTA, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.500 REMARK 3 NUMBER OF PARTICLES : 35611 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: POSTPROCESSING PERFORMED IN RELION 2.1 REMARK 4 REMARK 4 6NC3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000238541. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : COMPLEX OF AMC011 V4.2 SOSIP REMARK 245 TRIMER AND VRC34.01 FRAGMENT REMARK 245 ANTIGEN BINDING; HIV-1 ENV REMARK 245 AMC011 V4.2 SOSIP GP120; HIV-1 REMARK 245 ENV AMC011 V4.2 SOSIP GP41; REMARK 245 VRC34.01 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 5.00 REMARK 245 SAMPLE SUPPORT DETAILS : GATAN SOLARUS 950 PLASMA SYSTEM REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2834 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 56.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 29000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, H, L, C, I, O, T, D, J, REMARK 350 AND CHAINS: P, U, E, K, Q, V, F, M, R, REMARK 350 AND CHAINS: W, G, N, S, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r, s, t, u, v, REMARK 350 AND CHAINS: w, x, y, z, 0, 1, 2, 3, 4, REMARK 350 AND CHAINS: 5, 6, 7, 8, 9, AA, BA, CA, DA REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -4 REMARK 465 ASP A -3 REMARK 465 ALA A -2 REMARK 465 MET A -1 REMARK 465 LYS A 0 REMARK 465 ARG A 1 REMARK 465 GLY A 2 REMARK 465 LEU A 3 REMARK 465 CYS A 4 REMARK 465 CYS A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 LEU A 9 REMARK 465 CYS A 10 REMARK 465 GLY A 11 REMARK 465 ALA A 12 REMARK 465 VAL A 13 REMARK 465 PHE A 14 REMARK 465 VAL A 15 REMARK 465 SER A 16 REMARK 465 PRO A 17 REMARK 465 SER A 18 REMARK 465 GLN A 19 REMARK 465 GLU A 20 REMARK 465 ILE A 21 REMARK 465 HIS A 22 REMARK 465 ALA A 23 REMARK 465 ARG A 24 REMARK 465 PHE A 25 REMARK 465 ARG A 26 REMARK 465 ARG A 27 REMARK 465 GLY A 28 REMARK 465 ALA A 29 REMARK 465 ARG A 30 REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 ASN A 135A REMARK 465 ALA A 135B REMARK 465 THR A 135C REMARK 465 ASN A 135D REMARK 465 THR A 135E REMARK 465 ASN A 135F REMARK 465 ALA A 135G REMARK 465 THR A 135H REMARK 465 ASN A 135I REMARK 465 THR A 135J REMARK 465 THR A 135K REMARK 465 SER A 135L REMARK 465 SER A 135M REMARK 465 SER A 135N REMARK 465 ARG A 135O REMARK 465 GLY A 135P REMARK 465 THR A 135Q REMARK 465 MET A 135R REMARK 465 GLU A 135S REMARK 465 GLY A 135T REMARK 465 TRP A 404 REMARK 465 ASN A 405 REMARK 465 ASP A 406 REMARK 465 GLY A 407 REMARK 465 SER A 408 REMARK 465 ASN A 409 REMARK 465 TYR A 410 REMARK 465 THR A 411 REMARK 465 GLY A 412 REMARK 465 THR A 413 REMARK 465 GLY A 457A REMARK 465 GLY A 457B REMARK 465 LYS A 457C REMARK 465 ASN A 457D REMARK 465 ARG A 457E REMARK 465 SER A 457F REMARK 465 GLU A 457G REMARK 465 ASN A 457H REMARK 465 THR A 457I REMARK 465 VAL A 506 REMARK 465 GLN A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 LEU B 543A REMARK 465 LEU B 543B REMARK 465 SER B 543C REMARK 465 GLY B 543D REMARK 465 ILE B 543E REMARK 465 VAL B 543F REMARK 465 GLN B 543G REMARK 465 GLN B 543H REMARK 465 GLN B 543I REMARK 465 ASN B 543J REMARK 465 ASN B 543K REMARK 465 LEU B 543L REMARK 465 LEU B 543M REMARK 465 ARG B 543N REMARK 465 ALA B 543O REMARK 465 PRO B 543P REMARK 465 GLU B 543Q REMARK 465 ALA B 543R REMARK 465 GLN B 543S REMARK 465 GLN B 543T REMARK 465 HIS B 543U REMARK 465 LEU B 543V REMARK 465 LEU B 543W REMARK 465 LYS B 543X REMARK 465 LEU B 543Y REMARK 465 GLN H 1 REMARK 465 SER H 112 REMARK 465 SER H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 LYS H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ALA L 211 REMARK 465 MET C -4 REMARK 465 ASP C -3 REMARK 465 ALA C -2 REMARK 465 MET C -1 REMARK 465 LYS C 0 REMARK 465 ARG C 1 REMARK 465 GLY C 2 REMARK 465 LEU C 3 REMARK 465 CYS C 4 REMARK 465 CYS C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 LEU C 9 REMARK 465 CYS C 10 REMARK 465 GLY C 11 REMARK 465 ALA C 12 REMARK 465 VAL C 13 REMARK 465 PHE C 14 REMARK 465 VAL C 15 REMARK 465 SER C 16 REMARK 465 PRO C 17 REMARK 465 SER C 18 REMARK 465 GLN C 19 REMARK 465 GLU C 20 REMARK 465 ILE C 21 REMARK 465 HIS C 22 REMARK 465 ALA C 23 REMARK 465 ARG C 24 REMARK 465 PHE C 25 REMARK 465 ARG C 26 REMARK 465 ARG C 27 REMARK 465 GLY C 28 REMARK 465 ALA C 29 REMARK 465 ARG C 30 REMARK 465 ALA C 31 REMARK 465 GLU C 32 REMARK 465 ASN C 135A REMARK 465 ALA C 135B REMARK 465 THR C 135C REMARK 465 ASN C 135D REMARK 465 THR C 135E REMARK 465 ASN C 135F REMARK 465 ALA C 135G REMARK 465 THR C 135H REMARK 465 ASN C 135I REMARK 465 THR C 135J REMARK 465 THR C 135K REMARK 465 SER C 135L REMARK 465 SER C 135M REMARK 465 SER C 135N REMARK 465 ARG C 135O REMARK 465 GLY C 135P REMARK 465 THR C 135Q REMARK 465 MET C 135R REMARK 465 GLU C 135S REMARK 465 GLY C 135T REMARK 465 TRP C 404 REMARK 465 ASN C 405 REMARK 465 ASP C 406 REMARK 465 GLY C 407 REMARK 465 SER C 408 REMARK 465 ASN C 409 REMARK 465 TYR C 410 REMARK 465 THR C 411 REMARK 465 GLY C 412 REMARK 465 THR C 413 REMARK 465 GLY C 457A REMARK 465 GLY C 457B REMARK 465 LYS C 457C REMARK 465 ASN C 457D REMARK 465 ARG C 457E REMARK 465 SER C 457F REMARK 465 GLU C 457G REMARK 465 ASN C 457H REMARK 465 THR C 457I REMARK 465 VAL C 506 REMARK 465 GLN C 507 REMARK 465 ARG C 508 REMARK 465 ARG C 509 REMARK 465 ARG C 510 REMARK 465 ARG C 511 REMARK 465 ARG C 512 REMARK 465 ARG C 513 REMARK 465 LEU I 543A REMARK 465 LEU I 543B REMARK 465 SER I 543C REMARK 465 GLY I 543D REMARK 465 ILE I 543E REMARK 465 VAL I 543F REMARK 465 GLN I 543G REMARK 465 GLN I 543H REMARK 465 GLN I 543I REMARK 465 ASN I 543J REMARK 465 ASN I 543K REMARK 465 LEU I 543L REMARK 465 LEU I 543M REMARK 465 ARG I 543N REMARK 465 ALA I 543O REMARK 465 PRO I 543P REMARK 465 GLU I 543Q REMARK 465 ALA I 543R REMARK 465 GLN I 543S REMARK 465 GLN I 543T REMARK 465 HIS I 543U REMARK 465 LEU I 543V REMARK 465 LEU I 543W REMARK 465 LYS I 543X REMARK 465 LEU I 543Y REMARK 465 GLN O 1 REMARK 465 SER O 112 REMARK 465 SER O 113 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 LYS O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 ARG T 108 REMARK 465 THR T 109 REMARK 465 VAL T 110 REMARK 465 ALA T 111 REMARK 465 ALA T 112 REMARK 465 PRO T 113 REMARK 465 SER T 114 REMARK 465 VAL T 115 REMARK 465 PHE T 116 REMARK 465 ILE T 117 REMARK 465 PHE T 118 REMARK 465 PRO T 119 REMARK 465 PRO T 120 REMARK 465 SER T 121 REMARK 465 ASP T 122 REMARK 465 GLU T 123 REMARK 465 GLN T 124 REMARK 465 LEU T 125 REMARK 465 LYS T 126 REMARK 465 SER T 127 REMARK 465 GLY T 128 REMARK 465 THR T 129 REMARK 465 ALA T 130 REMARK 465 SER T 131 REMARK 465 VAL T 132 REMARK 465 VAL T 133 REMARK 465 CYS T 134 REMARK 465 LEU T 135 REMARK 465 LEU T 136 REMARK 465 ASN T 137 REMARK 465 ASN T 138 REMARK 465 PHE T 139 REMARK 465 TYR T 140 REMARK 465 PRO T 141 REMARK 465 ARG T 142 REMARK 465 GLU T 143 REMARK 465 ALA T 144 REMARK 465 LYS T 145 REMARK 465 VAL T 146 REMARK 465 GLN T 147 REMARK 465 TRP T 148 REMARK 465 LYS T 149 REMARK 465 VAL T 150 REMARK 465 ASP T 151 REMARK 465 ASN T 152 REMARK 465 ALA T 153 REMARK 465 LEU T 154 REMARK 465 GLN T 155 REMARK 465 SER T 156 REMARK 465 GLY T 157 REMARK 465 ASN T 158 REMARK 465 SER T 159 REMARK 465 GLN T 160 REMARK 465 GLU T 161 REMARK 465 SER T 162 REMARK 465 VAL T 163 REMARK 465 THR T 164 REMARK 465 GLU T 165 REMARK 465 GLN T 166 REMARK 465 ASP T 167 REMARK 465 SER T 168 REMARK 465 LYS T 169 REMARK 465 ASP T 170 REMARK 465 SER T 171 REMARK 465 THR T 172 REMARK 465 TYR T 173 REMARK 465 SER T 174 REMARK 465 LEU T 175 REMARK 465 SER T 176 REMARK 465 SER T 177 REMARK 465 THR T 178 REMARK 465 LEU T 179 REMARK 465 THR T 180 REMARK 465 LEU T 181 REMARK 465 SER T 182 REMARK 465 LYS T 183 REMARK 465 ALA T 184 REMARK 465 ASP T 185 REMARK 465 TYR T 186 REMARK 465 GLU T 187 REMARK 465 LYS T 188 REMARK 465 HIS T 189 REMARK 465 LYS T 190 REMARK 465 VAL T 191 REMARK 465 TYR T 192 REMARK 465 ALA T 193 REMARK 465 CYS T 194 REMARK 465 GLU T 195 REMARK 465 VAL T 196 REMARK 465 THR T 197 REMARK 465 HIS T 198 REMARK 465 GLN T 199 REMARK 465 GLY T 200 REMARK 465 LEU T 201 REMARK 465 SER T 202 REMARK 465 SER T 203 REMARK 465 PRO T 204 REMARK 465 VAL T 205 REMARK 465 THR T 206 REMARK 465 LYS T 207 REMARK 465 SER T 208 REMARK 465 PHE T 209 REMARK 465 ASN T 210 REMARK 465 ALA T 211 REMARK 465 MET D -4 REMARK 465 ASP D -3 REMARK 465 ALA D -2 REMARK 465 MET D -1 REMARK 465 LYS D 0 REMARK 465 ARG D 1 REMARK 465 GLY D 2 REMARK 465 LEU D 3 REMARK 465 CYS D 4 REMARK 465 CYS D 5 REMARK 465 VAL D 6 REMARK 465 LEU D 7 REMARK 465 LEU D 8 REMARK 465 LEU D 9 REMARK 465 CYS D 10 REMARK 465 GLY D 11 REMARK 465 ALA D 12 REMARK 465 VAL D 13 REMARK 465 PHE D 14 REMARK 465 VAL D 15 REMARK 465 SER D 16 REMARK 465 PRO D 17 REMARK 465 SER D 18 REMARK 465 GLN D 19 REMARK 465 GLU D 20 REMARK 465 ILE D 21 REMARK 465 HIS D 22 REMARK 465 ALA D 23 REMARK 465 ARG D 24 REMARK 465 PHE D 25 REMARK 465 ARG D 26 REMARK 465 ARG D 27 REMARK 465 GLY D 28 REMARK 465 ALA D 29 REMARK 465 ARG D 30 REMARK 465 ALA D 31 REMARK 465 GLU D 32 REMARK 465 ASN D 135A REMARK 465 ALA D 135B REMARK 465 THR D 135C REMARK 465 ASN D 135D REMARK 465 THR D 135E REMARK 465 ASN D 135F REMARK 465 ALA D 135G REMARK 465 THR D 135H REMARK 465 ASN D 135I REMARK 465 THR D 135J REMARK 465 THR D 135K REMARK 465 SER D 135L REMARK 465 SER D 135M REMARK 465 SER D 135N REMARK 465 ARG D 135O REMARK 465 GLY D 135P REMARK 465 THR D 135Q REMARK 465 MET D 135R REMARK 465 GLU D 135S REMARK 465 GLY D 135T REMARK 465 TRP D 404 REMARK 465 ASN D 405 REMARK 465 ASP D 406 REMARK 465 GLY D 407 REMARK 465 SER D 408 REMARK 465 ASN D 409 REMARK 465 TYR D 410 REMARK 465 THR D 411 REMARK 465 GLY D 412 REMARK 465 THR D 413 REMARK 465 GLY D 457A REMARK 465 GLY D 457B REMARK 465 LYS D 457C REMARK 465 ASN D 457D REMARK 465 ARG D 457E REMARK 465 SER D 457F REMARK 465 GLU D 457G REMARK 465 ASN D 457H REMARK 465 THR D 457I REMARK 465 VAL D 506 REMARK 465 GLN D 507 REMARK 465 ARG D 508 REMARK 465 ARG D 509 REMARK 465 ARG D 510 REMARK 465 ARG D 511 REMARK 465 ARG D 512 REMARK 465 ARG D 513 REMARK 465 LEU J 543A REMARK 465 LEU J 543B REMARK 465 SER J 543C REMARK 465 GLY J 543D REMARK 465 ILE J 543E REMARK 465 VAL J 543F REMARK 465 GLN J 543G REMARK 465 GLN J 543H REMARK 465 GLN J 543I REMARK 465 ASN J 543J REMARK 465 ASN J 543K REMARK 465 LEU J 543L REMARK 465 LEU J 543M REMARK 465 ARG J 543N REMARK 465 ALA J 543O REMARK 465 PRO J 543P REMARK 465 GLU J 543Q REMARK 465 ALA J 543R REMARK 465 GLN J 543S REMARK 465 GLN J 543T REMARK 465 HIS J 543U REMARK 465 LEU J 543V REMARK 465 LEU J 543W REMARK 465 LYS J 543X REMARK 465 LEU J 543Y REMARK 465 GLN P 1 REMARK 465 SER P 112 REMARK 465 SER P 113 REMARK 465 ALA P 114 REMARK 465 SER P 115 REMARK 465 THR P 116 REMARK 465 LYS P 117 REMARK 465 GLY P 118 REMARK 465 PRO P 119 REMARK 465 SER P 120 REMARK 465 VAL P 121 REMARK 465 PHE P 122 REMARK 465 PRO P 123 REMARK 465 LEU P 124 REMARK 465 ALA P 125 REMARK 465 PRO P 126 REMARK 465 SER P 127 REMARK 465 SER P 128 REMARK 465 LYS P 129 REMARK 465 SER P 130 REMARK 465 THR P 131 REMARK 465 SER P 132 REMARK 465 GLY P 133 REMARK 465 GLY P 134 REMARK 465 THR P 135 REMARK 465 ALA P 136 REMARK 465 ALA P 137 REMARK 465 LEU P 138 REMARK 465 GLY P 139 REMARK 465 CYS P 140 REMARK 465 LEU P 141 REMARK 465 VAL P 142 REMARK 465 LYS P 143 REMARK 465 ASP P 144 REMARK 465 TYR P 145 REMARK 465 PHE P 146 REMARK 465 PRO P 147 REMARK 465 GLU P 148 REMARK 465 PRO P 149 REMARK 465 VAL P 150 REMARK 465 THR P 151 REMARK 465 VAL P 152 REMARK 465 SER P 153 REMARK 465 TRP P 154 REMARK 465 ASN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ALA P 158 REMARK 465 LEU P 159 REMARK 465 THR P 160 REMARK 465 SER P 161 REMARK 465 GLY P 162 REMARK 465 VAL P 163 REMARK 465 HIS P 164 REMARK 465 THR P 165 REMARK 465 PHE P 166 REMARK 465 PRO P 167 REMARK 465 ALA P 168 REMARK 465 VAL P 169 REMARK 465 LEU P 170 REMARK 465 GLN P 171 REMARK 465 SER P 172 REMARK 465 SER P 173 REMARK 465 GLY P 174 REMARK 465 LEU P 175 REMARK 465 TYR P 176 REMARK 465 SER P 177 REMARK 465 LEU P 178 REMARK 465 SER P 179 REMARK 465 SER P 180 REMARK 465 VAL P 181 REMARK 465 VAL P 182 REMARK 465 THR P 183 REMARK 465 VAL P 184 REMARK 465 PRO P 185 REMARK 465 SER P 186 REMARK 465 SER P 187 REMARK 465 SER P 188 REMARK 465 LEU P 189 REMARK 465 GLY P 190 REMARK 465 THR P 191 REMARK 465 GLN P 192 REMARK 465 THR P 193 REMARK 465 TYR P 194 REMARK 465 ILE P 195 REMARK 465 CYS P 196 REMARK 465 ASN P 197 REMARK 465 VAL P 198 REMARK 465 ASN P 199 REMARK 465 HIS P 200 REMARK 465 LYS P 201 REMARK 465 PRO P 202 REMARK 465 SER P 203 REMARK 465 ASN P 204 REMARK 465 THR P 205 REMARK 465 LYS P 206 REMARK 465 VAL P 207 REMARK 465 ASP P 208 REMARK 465 LYS P 209 REMARK 465 LYS P 210 REMARK 465 VAL P 211 REMARK 465 GLU P 212 REMARK 465 PRO P 213 REMARK 465 ARG U 108 REMARK 465 THR U 109 REMARK 465 VAL U 110 REMARK 465 ALA U 111 REMARK 465 ALA U 112 REMARK 465 PRO U 113 REMARK 465 SER U 114 REMARK 465 VAL U 115 REMARK 465 PHE U 116 REMARK 465 ILE U 117 REMARK 465 PHE U 118 REMARK 465 PRO U 119 REMARK 465 PRO U 120 REMARK 465 SER U 121 REMARK 465 ASP U 122 REMARK 465 GLU U 123 REMARK 465 GLN U 124 REMARK 465 LEU U 125 REMARK 465 LYS U 126 REMARK 465 SER U 127 REMARK 465 GLY U 128 REMARK 465 THR U 129 REMARK 465 ALA U 130 REMARK 465 SER U 131 REMARK 465 VAL U 132 REMARK 465 VAL U 133 REMARK 465 CYS U 134 REMARK 465 LEU U 135 REMARK 465 LEU U 136 REMARK 465 ASN U 137 REMARK 465 ASN U 138 REMARK 465 PHE U 139 REMARK 465 TYR U 140 REMARK 465 PRO U 141 REMARK 465 ARG U 142 REMARK 465 GLU U 143 REMARK 465 ALA U 144 REMARK 465 LYS U 145 REMARK 465 VAL U 146 REMARK 465 GLN U 147 REMARK 465 TRP U 148 REMARK 465 LYS U 149 REMARK 465 VAL U 150 REMARK 465 ASP U 151 REMARK 465 ASN U 152 REMARK 465 ALA U 153 REMARK 465 LEU U 154 REMARK 465 GLN U 155 REMARK 465 SER U 156 REMARK 465 GLY U 157 REMARK 465 ASN U 158 REMARK 465 SER U 159 REMARK 465 GLN U 160 REMARK 465 GLU U 161 REMARK 465 SER U 162 REMARK 465 VAL U 163 REMARK 465 THR U 164 REMARK 465 GLU U 165 REMARK 465 GLN U 166 REMARK 465 ASP U 167 REMARK 465 SER U 168 REMARK 465 LYS U 169 REMARK 465 ASP U 170 REMARK 465 SER U 171 REMARK 465 THR U 172 REMARK 465 TYR U 173 REMARK 465 SER U 174 REMARK 465 LEU U 175 REMARK 465 SER U 176 REMARK 465 SER U 177 REMARK 465 THR U 178 REMARK 465 LEU U 179 REMARK 465 THR U 180 REMARK 465 LEU U 181 REMARK 465 SER U 182 REMARK 465 LYS U 183 REMARK 465 ALA U 184 REMARK 465 ASP U 185 REMARK 465 TYR U 186 REMARK 465 GLU U 187 REMARK 465 LYS U 188 REMARK 465 HIS U 189 REMARK 465 LYS U 190 REMARK 465 VAL U 191 REMARK 465 TYR U 192 REMARK 465 ALA U 193 REMARK 465 CYS U 194 REMARK 465 GLU U 195 REMARK 465 VAL U 196 REMARK 465 THR U 197 REMARK 465 HIS U 198 REMARK 465 GLN U 199 REMARK 465 GLY U 200 REMARK 465 LEU U 201 REMARK 465 SER U 202 REMARK 465 SER U 203 REMARK 465 PRO U 204 REMARK 465 VAL U 205 REMARK 465 THR U 206 REMARK 465 LYS U 207 REMARK 465 SER U 208 REMARK 465 PHE U 209 REMARK 465 ASN U 210 REMARK 465 ALA U 211 REMARK 465 MET E -4 REMARK 465 ASP E -3 REMARK 465 ALA E -2 REMARK 465 MET E -1 REMARK 465 LYS E 0 REMARK 465 ARG E 1 REMARK 465 GLY E 2 REMARK 465 LEU E 3 REMARK 465 CYS E 4 REMARK 465 CYS E 5 REMARK 465 VAL E 6 REMARK 465 LEU E 7 REMARK 465 LEU E 8 REMARK 465 LEU E 9 REMARK 465 CYS E 10 REMARK 465 GLY E 11 REMARK 465 ALA E 12 REMARK 465 VAL E 13 REMARK 465 PHE E 14 REMARK 465 VAL E 15 REMARK 465 SER E 16 REMARK 465 PRO E 17 REMARK 465 SER E 18 REMARK 465 GLN E 19 REMARK 465 GLU E 20 REMARK 465 ILE E 21 REMARK 465 HIS E 22 REMARK 465 ALA E 23 REMARK 465 ARG E 24 REMARK 465 PHE E 25 REMARK 465 ARG E 26 REMARK 465 ARG E 27 REMARK 465 GLY E 28 REMARK 465 ALA E 29 REMARK 465 ARG E 30 REMARK 465 ALA E 31 REMARK 465 GLU E 32 REMARK 465 ASN E 135A REMARK 465 ALA E 135B REMARK 465 THR E 135C REMARK 465 ASN E 135D REMARK 465 THR E 135E REMARK 465 ASN E 135F REMARK 465 ALA E 135G REMARK 465 THR E 135H REMARK 465 ASN E 135I REMARK 465 THR E 135J REMARK 465 THR E 135K REMARK 465 SER E 135L REMARK 465 SER E 135M REMARK 465 SER E 135N REMARK 465 ARG E 135O REMARK 465 GLY E 135P REMARK 465 THR E 135Q REMARK 465 MET E 135R REMARK 465 GLU E 135S REMARK 465 GLY E 135T REMARK 465 TRP E 404 REMARK 465 ASN E 405 REMARK 465 ASP E 406 REMARK 465 GLY E 407 REMARK 465 SER E 408 REMARK 465 ASN E 409 REMARK 465 TYR E 410 REMARK 465 THR E 411 REMARK 465 GLY E 412 REMARK 465 THR E 413 REMARK 465 GLY E 457A REMARK 465 GLY E 457B REMARK 465 LYS E 457C REMARK 465 ASN E 457D REMARK 465 ARG E 457E REMARK 465 SER E 457F REMARK 465 GLU E 457G REMARK 465 ASN E 457H REMARK 465 THR E 457I REMARK 465 VAL E 506 REMARK 465 GLN E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 LEU K 543A REMARK 465 LEU K 543B REMARK 465 SER K 543C REMARK 465 GLY K 543D REMARK 465 ILE K 543E REMARK 465 VAL K 543F REMARK 465 GLN K 543G REMARK 465 GLN K 543H REMARK 465 GLN K 543I REMARK 465 ASN K 543J REMARK 465 ASN K 543K REMARK 465 LEU K 543L REMARK 465 LEU K 543M REMARK 465 ARG K 543N REMARK 465 ALA K 543O REMARK 465 PRO K 543P REMARK 465 GLU K 543Q REMARK 465 ALA K 543R REMARK 465 GLN K 543S REMARK 465 GLN K 543T REMARK 465 HIS K 543U REMARK 465 LEU K 543V REMARK 465 LEU K 543W REMARK 465 LYS K 543X REMARK 465 LEU K 543Y REMARK 465 GLN Q 1 REMARK 465 SER Q 112 REMARK 465 SER Q 113 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 LYS Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 ARG V 108 REMARK 465 THR V 109 REMARK 465 VAL V 110 REMARK 465 ALA V 111 REMARK 465 ALA V 112 REMARK 465 PRO V 113 REMARK 465 SER V 114 REMARK 465 VAL V 115 REMARK 465 PHE V 116 REMARK 465 ILE V 117 REMARK 465 PHE V 118 REMARK 465 PRO V 119 REMARK 465 PRO V 120 REMARK 465 SER V 121 REMARK 465 ASP V 122 REMARK 465 GLU V 123 REMARK 465 GLN V 124 REMARK 465 LEU V 125 REMARK 465 LYS V 126 REMARK 465 SER V 127 REMARK 465 GLY V 128 REMARK 465 THR V 129 REMARK 465 ALA V 130 REMARK 465 SER V 131 REMARK 465 VAL V 132 REMARK 465 VAL V 133 REMARK 465 CYS V 134 REMARK 465 LEU V 135 REMARK 465 LEU V 136 REMARK 465 ASN V 137 REMARK 465 ASN V 138 REMARK 465 PHE V 139 REMARK 465 TYR V 140 REMARK 465 PRO V 141 REMARK 465 ARG V 142 REMARK 465 GLU V 143 REMARK 465 ALA V 144 REMARK 465 LYS V 145 REMARK 465 VAL V 146 REMARK 465 GLN V 147 REMARK 465 TRP V 148 REMARK 465 LYS V 149 REMARK 465 VAL V 150 REMARK 465 ASP V 151 REMARK 465 ASN V 152 REMARK 465 ALA V 153 REMARK 465 LEU V 154 REMARK 465 GLN V 155 REMARK 465 SER V 156 REMARK 465 GLY V 157 REMARK 465 ASN V 158 REMARK 465 SER V 159 REMARK 465 GLN V 160 REMARK 465 GLU V 161 REMARK 465 SER V 162 REMARK 465 VAL V 163 REMARK 465 THR V 164 REMARK 465 GLU V 165 REMARK 465 GLN V 166 REMARK 465 ASP V 167 REMARK 465 SER V 168 REMARK 465 LYS V 169 REMARK 465 ASP V 170 REMARK 465 SER V 171 REMARK 465 THR V 172 REMARK 465 TYR V 173 REMARK 465 SER V 174 REMARK 465 LEU V 175 REMARK 465 SER V 176 REMARK 465 SER V 177 REMARK 465 THR V 178 REMARK 465 LEU V 179 REMARK 465 THR V 180 REMARK 465 LEU V 181 REMARK 465 SER V 182 REMARK 465 LYS V 183 REMARK 465 ALA V 184 REMARK 465 ASP V 185 REMARK 465 TYR V 186 REMARK 465 GLU V 187 REMARK 465 LYS V 188 REMARK 465 HIS V 189 REMARK 465 LYS V 190 REMARK 465 VAL V 191 REMARK 465 TYR V 192 REMARK 465 ALA V 193 REMARK 465 CYS V 194 REMARK 465 GLU V 195 REMARK 465 VAL V 196 REMARK 465 THR V 197 REMARK 465 HIS V 198 REMARK 465 GLN V 199 REMARK 465 GLY V 200 REMARK 465 LEU V 201 REMARK 465 SER V 202 REMARK 465 SER V 203 REMARK 465 PRO V 204 REMARK 465 VAL V 205 REMARK 465 THR V 206 REMARK 465 LYS V 207 REMARK 465 SER V 208 REMARK 465 PHE V 209 REMARK 465 ASN V 210 REMARK 465 ALA V 211 REMARK 465 MET F -4 REMARK 465 ASP F -3 REMARK 465 ALA F -2 REMARK 465 MET F -1 REMARK 465 LYS F 0 REMARK 465 ARG F 1 REMARK 465 GLY F 2 REMARK 465 LEU F 3 REMARK 465 CYS F 4 REMARK 465 CYS F 5 REMARK 465 VAL F 6 REMARK 465 LEU F 7 REMARK 465 LEU F 8 REMARK 465 LEU F 9 REMARK 465 CYS F 10 REMARK 465 GLY F 11 REMARK 465 ALA F 12 REMARK 465 VAL F 13 REMARK 465 PHE F 14 REMARK 465 VAL F 15 REMARK 465 SER F 16 REMARK 465 PRO F 17 REMARK 465 SER F 18 REMARK 465 GLN F 19 REMARK 465 GLU F 20 REMARK 465 ILE F 21 REMARK 465 HIS F 22 REMARK 465 ALA F 23 REMARK 465 ARG F 24 REMARK 465 PHE F 25 REMARK 465 ARG F 26 REMARK 465 ARG F 27 REMARK 465 GLY F 28 REMARK 465 ALA F 29 REMARK 465 ARG F 30 REMARK 465 ALA F 31 REMARK 465 GLU F 32 REMARK 465 ASN F 135A REMARK 465 ALA F 135B REMARK 465 THR F 135C REMARK 465 ASN F 135D REMARK 465 THR F 135E REMARK 465 ASN F 135F REMARK 465 ALA F 135G REMARK 465 THR F 135H REMARK 465 ASN F 135I REMARK 465 THR F 135J REMARK 465 THR F 135K REMARK 465 SER F 135L REMARK 465 SER F 135M REMARK 465 SER F 135N REMARK 465 ARG F 135O REMARK 465 GLY F 135P REMARK 465 THR F 135Q REMARK 465 MET F 135R REMARK 465 GLU F 135S REMARK 465 GLY F 135T REMARK 465 TRP F 404 REMARK 465 ASN F 405 REMARK 465 ASP F 406 REMARK 465 GLY F 407 REMARK 465 SER F 408 REMARK 465 ASN F 409 REMARK 465 TYR F 410 REMARK 465 THR F 411 REMARK 465 GLY F 412 REMARK 465 THR F 413 REMARK 465 GLY F 457A REMARK 465 GLY F 457B REMARK 465 LYS F 457C REMARK 465 ASN F 457D REMARK 465 ARG F 457E REMARK 465 SER F 457F REMARK 465 GLU F 457G REMARK 465 ASN F 457H REMARK 465 THR F 457I REMARK 465 VAL F 506 REMARK 465 GLN F 507 REMARK 465 ARG F 508 REMARK 465 ARG F 509 REMARK 465 ARG F 510 REMARK 465 ARG F 511 REMARK 465 ARG F 512 REMARK 465 ARG F 513 REMARK 465 LEU M 543A REMARK 465 LEU M 543B REMARK 465 SER M 543C REMARK 465 GLY M 543D REMARK 465 ILE M 543E REMARK 465 VAL M 543F REMARK 465 GLN M 543G REMARK 465 GLN M 543H REMARK 465 GLN M 543I REMARK 465 ASN M 543J REMARK 465 ASN M 543K REMARK 465 LEU M 543L REMARK 465 LEU M 543M REMARK 465 ARG M 543N REMARK 465 ALA M 543O REMARK 465 PRO M 543P REMARK 465 GLU M 543Q REMARK 465 ALA M 543R REMARK 465 GLN M 543S REMARK 465 GLN M 543T REMARK 465 HIS M 543U REMARK 465 LEU M 543V REMARK 465 LEU M 543W REMARK 465 LYS M 543X REMARK 465 LEU M 543Y REMARK 465 GLN R 1 REMARK 465 SER R 112 REMARK 465 SER R 113 REMARK 465 ALA R 114 REMARK 465 SER R 115 REMARK 465 THR R 116 REMARK 465 LYS R 117 REMARK 465 GLY R 118 REMARK 465 PRO R 119 REMARK 465 SER R 120 REMARK 465 VAL R 121 REMARK 465 PHE R 122 REMARK 465 PRO R 123 REMARK 465 LEU R 124 REMARK 465 ALA R 125 REMARK 465 PRO R 126 REMARK 465 SER R 127 REMARK 465 SER R 128 REMARK 465 LYS R 129 REMARK 465 SER R 130 REMARK 465 THR R 131 REMARK 465 SER R 132 REMARK 465 GLY R 133 REMARK 465 GLY R 134 REMARK 465 THR R 135 REMARK 465 ALA R 136 REMARK 465 ALA R 137 REMARK 465 LEU R 138 REMARK 465 GLY R 139 REMARK 465 CYS R 140 REMARK 465 LEU R 141 REMARK 465 VAL R 142 REMARK 465 LYS R 143 REMARK 465 ASP R 144 REMARK 465 TYR R 145 REMARK 465 PHE R 146 REMARK 465 PRO R 147 REMARK 465 GLU R 148 REMARK 465 PRO R 149 REMARK 465 VAL R 150 REMARK 465 THR R 151 REMARK 465 VAL R 152 REMARK 465 SER R 153 REMARK 465 TRP R 154 REMARK 465 ASN R 155 REMARK 465 SER R 156 REMARK 465 GLY R 157 REMARK 465 ALA R 158 REMARK 465 LEU R 159 REMARK 465 THR R 160 REMARK 465 SER R 161 REMARK 465 GLY R 162 REMARK 465 VAL R 163 REMARK 465 HIS R 164 REMARK 465 THR R 165 REMARK 465 PHE R 166 REMARK 465 PRO R 167 REMARK 465 ALA R 168 REMARK 465 VAL R 169 REMARK 465 LEU R 170 REMARK 465 GLN R 171 REMARK 465 SER R 172 REMARK 465 SER R 173 REMARK 465 GLY R 174 REMARK 465 LEU R 175 REMARK 465 TYR R 176 REMARK 465 SER R 177 REMARK 465 LEU R 178 REMARK 465 SER R 179 REMARK 465 SER R 180 REMARK 465 VAL R 181 REMARK 465 VAL R 182 REMARK 465 THR R 183 REMARK 465 VAL R 184 REMARK 465 PRO R 185 REMARK 465 SER R 186 REMARK 465 SER R 187 REMARK 465 SER R 188 REMARK 465 LEU R 189 REMARK 465 GLY R 190 REMARK 465 THR R 191 REMARK 465 GLN R 192 REMARK 465 THR R 193 REMARK 465 TYR R 194 REMARK 465 ILE R 195 REMARK 465 CYS R 196 REMARK 465 ASN R 197 REMARK 465 VAL R 198 REMARK 465 ASN R 199 REMARK 465 HIS R 200 REMARK 465 LYS R 201 REMARK 465 PRO R 202 REMARK 465 SER R 203 REMARK 465 ASN R 204 REMARK 465 THR R 205 REMARK 465 LYS R 206 REMARK 465 VAL R 207 REMARK 465 ASP R 208 REMARK 465 LYS R 209 REMARK 465 LYS R 210 REMARK 465 VAL R 211 REMARK 465 GLU R 212 REMARK 465 PRO R 213 REMARK 465 ARG W 108 REMARK 465 THR W 109 REMARK 465 VAL W 110 REMARK 465 ALA W 111 REMARK 465 ALA W 112 REMARK 465 PRO W 113 REMARK 465 SER W 114 REMARK 465 VAL W 115 REMARK 465 PHE W 116 REMARK 465 ILE W 117 REMARK 465 PHE W 118 REMARK 465 PRO W 119 REMARK 465 PRO W 120 REMARK 465 SER W 121 REMARK 465 ASP W 122 REMARK 465 GLU W 123 REMARK 465 GLN W 124 REMARK 465 LEU W 125 REMARK 465 LYS W 126 REMARK 465 SER W 127 REMARK 465 GLY W 128 REMARK 465 THR W 129 REMARK 465 ALA W 130 REMARK 465 SER W 131 REMARK 465 VAL W 132 REMARK 465 VAL W 133 REMARK 465 CYS W 134 REMARK 465 LEU W 135 REMARK 465 LEU W 136 REMARK 465 ASN W 137 REMARK 465 ASN W 138 REMARK 465 PHE W 139 REMARK 465 TYR W 140 REMARK 465 PRO W 141 REMARK 465 ARG W 142 REMARK 465 GLU W 143 REMARK 465 ALA W 144 REMARK 465 LYS W 145 REMARK 465 VAL W 146 REMARK 465 GLN W 147 REMARK 465 TRP W 148 REMARK 465 LYS W 149 REMARK 465 VAL W 150 REMARK 465 ASP W 151 REMARK 465 ASN W 152 REMARK 465 ALA W 153 REMARK 465 LEU W 154 REMARK 465 GLN W 155 REMARK 465 SER W 156 REMARK 465 GLY W 157 REMARK 465 ASN W 158 REMARK 465 SER W 159 REMARK 465 GLN W 160 REMARK 465 GLU W 161 REMARK 465 SER W 162 REMARK 465 VAL W 163 REMARK 465 THR W 164 REMARK 465 GLU W 165 REMARK 465 GLN W 166 REMARK 465 ASP W 167 REMARK 465 SER W 168 REMARK 465 LYS W 169 REMARK 465 ASP W 170 REMARK 465 SER W 171 REMARK 465 THR W 172 REMARK 465 TYR W 173 REMARK 465 SER W 174 REMARK 465 LEU W 175 REMARK 465 SER W 176 REMARK 465 SER W 177 REMARK 465 THR W 178 REMARK 465 LEU W 179 REMARK 465 THR W 180 REMARK 465 LEU W 181 REMARK 465 SER W 182 REMARK 465 LYS W 183 REMARK 465 ALA W 184 REMARK 465 ASP W 185 REMARK 465 TYR W 186 REMARK 465 GLU W 187 REMARK 465 LYS W 188 REMARK 465 HIS W 189 REMARK 465 LYS W 190 REMARK 465 VAL W 191 REMARK 465 TYR W 192 REMARK 465 ALA W 193 REMARK 465 CYS W 194 REMARK 465 GLU W 195 REMARK 465 VAL W 196 REMARK 465 THR W 197 REMARK 465 HIS W 198 REMARK 465 GLN W 199 REMARK 465 GLY W 200 REMARK 465 LEU W 201 REMARK 465 SER W 202 REMARK 465 SER W 203 REMARK 465 PRO W 204 REMARK 465 VAL W 205 REMARK 465 THR W 206 REMARK 465 LYS W 207 REMARK 465 SER W 208 REMARK 465 PHE W 209 REMARK 465 ASN W 210 REMARK 465 ALA W 211 REMARK 465 MET G -4 REMARK 465 ASP G -3 REMARK 465 ALA G -2 REMARK 465 MET G -1 REMARK 465 LYS G 0 REMARK 465 ARG G 1 REMARK 465 GLY G 2 REMARK 465 LEU G 3 REMARK 465 CYS G 4 REMARK 465 CYS G 5 REMARK 465 VAL G 6 REMARK 465 LEU G 7 REMARK 465 LEU G 8 REMARK 465 LEU G 9 REMARK 465 CYS G 10 REMARK 465 GLY G 11 REMARK 465 ALA G 12 REMARK 465 VAL G 13 REMARK 465 PHE G 14 REMARK 465 VAL G 15 REMARK 465 SER G 16 REMARK 465 PRO G 17 REMARK 465 SER G 18 REMARK 465 GLN G 19 REMARK 465 GLU G 20 REMARK 465 ILE G 21 REMARK 465 HIS G 22 REMARK 465 ALA G 23 REMARK 465 ARG G 24 REMARK 465 PHE G 25 REMARK 465 ARG G 26 REMARK 465 ARG G 27 REMARK 465 GLY G 28 REMARK 465 ALA G 29 REMARK 465 ARG G 30 REMARK 465 ALA G 31 REMARK 465 GLU G 32 REMARK 465 ASN G 135A REMARK 465 ALA G 135B REMARK 465 THR G 135C REMARK 465 ASN G 135D REMARK 465 THR G 135E REMARK 465 ASN G 135F REMARK 465 ALA G 135G REMARK 465 THR G 135H REMARK 465 ASN G 135I REMARK 465 THR G 135J REMARK 465 THR G 135K REMARK 465 SER G 135L REMARK 465 SER G 135M REMARK 465 SER G 135N REMARK 465 ARG G 135O REMARK 465 GLY G 135P REMARK 465 THR G 135Q REMARK 465 MET G 135R REMARK 465 GLU G 135S REMARK 465 GLY G 135T REMARK 465 TRP G 404 REMARK 465 ASN G 405 REMARK 465 ASP G 406 REMARK 465 GLY G 407 REMARK 465 SER G 408 REMARK 465 ASN G 409 REMARK 465 TYR G 410 REMARK 465 THR G 411 REMARK 465 GLY G 412 REMARK 465 THR G 413 REMARK 465 GLY G 457A REMARK 465 GLY G 457B REMARK 465 LYS G 457C REMARK 465 ASN G 457D REMARK 465 ARG G 457E REMARK 465 SER G 457F REMARK 465 GLU G 457G REMARK 465 ASN G 457H REMARK 465 THR G 457I REMARK 465 VAL G 506 REMARK 465 GLN G 507 REMARK 465 ARG G 508 REMARK 465 ARG G 509 REMARK 465 ARG G 510 REMARK 465 ARG G 511 REMARK 465 ARG G 512 REMARK 465 ARG G 513 REMARK 465 LEU N 543A REMARK 465 LEU N 543B REMARK 465 SER N 543C REMARK 465 GLY N 543D REMARK 465 ILE N 543E REMARK 465 VAL N 543F REMARK 465 GLN N 543G REMARK 465 GLN N 543H REMARK 465 GLN N 543I REMARK 465 ASN N 543J REMARK 465 ASN N 543K REMARK 465 LEU N 543L REMARK 465 LEU N 543M REMARK 465 ARG N 543N REMARK 465 ALA N 543O REMARK 465 PRO N 543P REMARK 465 GLU N 543Q REMARK 465 ALA N 543R REMARK 465 GLN N 543S REMARK 465 GLN N 543T REMARK 465 HIS N 543U REMARK 465 LEU N 543V REMARK 465 LEU N 543W REMARK 465 LYS N 543X REMARK 465 LEU N 543Y REMARK 465 GLN S 1 REMARK 465 SER S 112 REMARK 465 SER S 113 REMARK 465 ALA S 114 REMARK 465 SER S 115 REMARK 465 THR S 116 REMARK 465 LYS S 117 REMARK 465 GLY S 118 REMARK 465 PRO S 119 REMARK 465 SER S 120 REMARK 465 VAL S 121 REMARK 465 PHE S 122 REMARK 465 PRO S 123 REMARK 465 LEU S 124 REMARK 465 ALA S 125 REMARK 465 PRO S 126 REMARK 465 SER S 127 REMARK 465 SER S 128 REMARK 465 LYS S 129 REMARK 465 SER S 130 REMARK 465 THR S 131 REMARK 465 SER S 132 REMARK 465 GLY S 133 REMARK 465 GLY S 134 REMARK 465 THR S 135 REMARK 465 ALA S 136 REMARK 465 ALA S 137 REMARK 465 LEU S 138 REMARK 465 GLY S 139 REMARK 465 CYS S 140 REMARK 465 LEU S 141 REMARK 465 VAL S 142 REMARK 465 LYS S 143 REMARK 465 ASP S 144 REMARK 465 TYR S 145 REMARK 465 PHE S 146 REMARK 465 PRO S 147 REMARK 465 GLU S 148 REMARK 465 PRO S 149 REMARK 465 VAL S 150 REMARK 465 THR S 151 REMARK 465 VAL S 152 REMARK 465 SER S 153 REMARK 465 TRP S 154 REMARK 465 ASN S 155 REMARK 465 SER S 156 REMARK 465 GLY S 157 REMARK 465 ALA S 158 REMARK 465 LEU S 159 REMARK 465 THR S 160 REMARK 465 SER S 161 REMARK 465 GLY S 162 REMARK 465 VAL S 163 REMARK 465 HIS S 164 REMARK 465 THR S 165 REMARK 465 PHE S 166 REMARK 465 PRO S 167 REMARK 465 ALA S 168 REMARK 465 VAL S 169 REMARK 465 LEU S 170 REMARK 465 GLN S 171 REMARK 465 SER S 172 REMARK 465 SER S 173 REMARK 465 GLY S 174 REMARK 465 LEU S 175 REMARK 465 TYR S 176 REMARK 465 SER S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 SER S 180 REMARK 465 VAL S 181 REMARK 465 VAL S 182 REMARK 465 THR S 183 REMARK 465 VAL S 184 REMARK 465 PRO S 185 REMARK 465 SER S 186 REMARK 465 SER S 187 REMARK 465 SER S 188 REMARK 465 LEU S 189 REMARK 465 GLY S 190 REMARK 465 THR S 191 REMARK 465 GLN S 192 REMARK 465 THR S 193 REMARK 465 TYR S 194 REMARK 465 ILE S 195 REMARK 465 CYS S 196 REMARK 465 ASN S 197 REMARK 465 VAL S 198 REMARK 465 ASN S 199 REMARK 465 HIS S 200 REMARK 465 LYS S 201 REMARK 465 PRO S 202 REMARK 465 SER S 203 REMARK 465 ASN S 204 REMARK 465 THR S 205 REMARK 465 LYS S 206 REMARK 465 VAL S 207 REMARK 465 ASP S 208 REMARK 465 LYS S 209 REMARK 465 LYS S 210 REMARK 465 VAL S 211 REMARK 465 GLU S 212 REMARK 465 PRO S 213 REMARK 465 ARG X 108 REMARK 465 THR X 109 REMARK 465 VAL X 110 REMARK 465 ALA X 111 REMARK 465 ALA X 112 REMARK 465 PRO X 113 REMARK 465 SER X 114 REMARK 465 VAL X 115 REMARK 465 PHE X 116 REMARK 465 ILE X 117 REMARK 465 PHE X 118 REMARK 465 PRO X 119 REMARK 465 PRO X 120 REMARK 465 SER X 121 REMARK 465 ASP X 122 REMARK 465 GLU X 123 REMARK 465 GLN X 124 REMARK 465 LEU X 125 REMARK 465 LYS X 126 REMARK 465 SER X 127 REMARK 465 GLY X 128 REMARK 465 THR X 129 REMARK 465 ALA X 130 REMARK 465 SER X 131 REMARK 465 VAL X 132 REMARK 465 VAL X 133 REMARK 465 CYS X 134 REMARK 465 LEU X 135 REMARK 465 LEU X 136 REMARK 465 ASN X 137 REMARK 465 ASN X 138 REMARK 465 PHE X 139 REMARK 465 TYR X 140 REMARK 465 PRO X 141 REMARK 465 ARG X 142 REMARK 465 GLU X 143 REMARK 465 ALA X 144 REMARK 465 LYS X 145 REMARK 465 VAL X 146 REMARK 465 GLN X 147 REMARK 465 TRP X 148 REMARK 465 LYS X 149 REMARK 465 VAL X 150 REMARK 465 ASP X 151 REMARK 465 ASN X 152 REMARK 465 ALA X 153 REMARK 465 LEU X 154 REMARK 465 GLN X 155 REMARK 465 SER X 156 REMARK 465 GLY X 157 REMARK 465 ASN X 158 REMARK 465 SER X 159 REMARK 465 GLN X 160 REMARK 465 GLU X 161 REMARK 465 SER X 162 REMARK 465 VAL X 163 REMARK 465 THR X 164 REMARK 465 GLU X 165 REMARK 465 GLN X 166 REMARK 465 ASP X 167 REMARK 465 SER X 168 REMARK 465 LYS X 169 REMARK 465 ASP X 170 REMARK 465 SER X 171 REMARK 465 THR X 172 REMARK 465 TYR X 173 REMARK 465 SER X 174 REMARK 465 LEU X 175 REMARK 465 SER X 176 REMARK 465 SER X 177 REMARK 465 THR X 178 REMARK 465 LEU X 179 REMARK 465 THR X 180 REMARK 465 LEU X 181 REMARK 465 SER X 182 REMARK 465 LYS X 183 REMARK 465 ALA X 184 REMARK 465 ASP X 185 REMARK 465 TYR X 186 REMARK 465 GLU X 187 REMARK 465 LYS X 188 REMARK 465 HIS X 189 REMARK 465 LYS X 190 REMARK 465 VAL X 191 REMARK 465 TYR X 192 REMARK 465 ALA X 193 REMARK 465 CYS X 194 REMARK 465 GLU X 195 REMARK 465 VAL X 196 REMARK 465 THR X 197 REMARK 465 HIS X 198 REMARK 465 GLN X 199 REMARK 465 GLY X 200 REMARK 465 LEU X 201 REMARK 465 SER X 202 REMARK 465 SER X 203 REMARK 465 PRO X 204 REMARK 465 VAL X 205 REMARK 465 THR X 206 REMARK 465 LYS X 207 REMARK 465 SER X 208 REMARK 465 PHE X 209 REMARK 465 ASN X 210 REMARK 465 ALA X 211 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O6 BMA f 3 C2 MAN f 5 2.09 REMARK 500 O6 BMA 0 3 C2 MAN 0 5 2.09 REMARK 500 O6 BMA Y 3 C2 MAN Y 5 2.09 REMARK 500 O6 BMA t 3 C2 MAN t 5 2.09 REMARK 500 O6 BMA m 3 C2 MAN m 5 2.09 REMARK 500 O6 BMA 7 3 C2 MAN 7 5 2.09 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 GLU A 429 CG GLU A 429 CD -0.098 REMARK 500 CYS L 88 CB CYS L 88 SG -0.135 REMARK 500 GLU C 429 CG GLU C 429 CD -0.098 REMARK 500 CYS T 88 CB CYS T 88 SG -0.135 REMARK 500 GLU D 429 CG GLU D 429 CD -0.098 REMARK 500 CYS U 88 CB CYS U 88 SG -0.135 REMARK 500 GLU E 429 CG GLU E 429 CD -0.098 REMARK 500 CYS V 88 CB CYS V 88 SG -0.135 REMARK 500 GLU F 429 CG GLU F 429 CD -0.098 REMARK 500 CYS W 88 CB CYS W 88 SG -0.135 REMARK 500 GLU G 429 CG GLU G 429 CD -0.098 REMARK 500 CYS X 88 CB CYS X 88 SG -0.135 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 TYR A 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG A 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 ARG A 504 NE - CZ - NH2 ANGL. DEV. = -3.0 DEGREES REMARK 500 TYR C 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG C 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 ARG C 504 NE - CZ - NH2 ANGL. DEV. = -3.0 DEGREES REMARK 500 TYR D 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG D 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 TYR E 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG E 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 ARG E 504 NE - CZ - NH2 ANGL. DEV. = -3.0 DEGREES REMARK 500 TYR F 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG F 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 ARG F 504 NE - CZ - NH2 ANGL. DEV. = -3.0 DEGREES REMARK 500 TYR G 40 CB - CG - CD1 ANGL. DEV. = -3.9 DEGREES REMARK 500 ARG G 315 NE - CZ - NH2 ANGL. DEV. = -3.4 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA A 58 -44.70 -179.46 REMARK 500 ARG A 66 -42.05 -143.48 REMARK 500 SER A 164 -82.80 -112.94 REMARK 500 ARG A 166 -60.86 66.23 REMARK 500 ASN A 276 -34.73 -148.69 REMARK 500 THR A 278 -65.94 -134.49 REMARK 500 PHE A 361 74.32 64.86 REMARK 500 TRP A 427 -51.96 73.30 REMARK 500 GLN A 428 119.02 -175.77 REMARK 500 ALA B 517 61.85 62.88 REMARK 500 PHE B 522 -56.75 62.82 REMARK 500 ALA B 526 -31.58 -148.60 REMARK 500 SER H 7 -161.15 -69.82 REMARK 500 ARG L 30 -62.99 72.69 REMARK 500 ASN L 31 3.20 -157.11 REMARK 500 ALA L 51 11.03 57.01 REMARK 500 SER L 52 -11.96 -162.41 REMARK 500 SER L 77 74.70 -155.22 REMARK 500 SER L 93 -154.76 -154.11 REMARK 500 ALA C 58 -44.68 -179.49 REMARK 500 ARG C 66 -42.01 -143.47 REMARK 500 SER C 164 -82.78 -112.97 REMARK 500 ARG C 166 -60.81 66.18 REMARK 500 ASN C 276 -34.73 -148.70 REMARK 500 THR C 278 -65.93 -134.48 REMARK 500 PHE C 361 74.34 64.85 REMARK 500 TRP C 427 -51.97 73.33 REMARK 500 GLN C 428 119.03 -175.79 REMARK 500 ALA I 517 61.81 62.89 REMARK 500 PHE I 522 -56.76 62.84 REMARK 500 ALA I 526 -31.54 -148.61 REMARK 500 SER O 7 -161.15 -69.83 REMARK 500 ARG T 30 -62.99 72.73 REMARK 500 ASN T 31 3.15 -157.12 REMARK 500 ALA T 51 11.05 57.01 REMARK 500 SER T 52 -11.98 -162.44 REMARK 500 SER T 77 74.71 -155.22 REMARK 500 SER T 93 -154.78 -154.11 REMARK 500 ALA D 58 -44.67 -179.52 REMARK 500 ARG D 66 -41.99 -143.47 REMARK 500 SER D 164 -82.78 -112.96 REMARK 500 ARG D 166 -60.82 66.15 REMARK 500 ASN D 276 -34.68 -148.69 REMARK 500 THR D 278 -65.94 -134.49 REMARK 500 PHE D 361 74.27 64.90 REMARK 500 TRP D 427 -51.95 73.31 REMARK 500 GLN D 428 119.02 -175.79 REMARK 500 ALA J 517 61.85 62.88 REMARK 500 PHE J 522 -56.78 62.84 REMARK 500 ALA J 526 -31.57 -148.60 REMARK 500 REMARK 500 THIS ENTRY HAS 114 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-0434 RELATED DB: EMDB REMARK 900 AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE REMARK 900 TARGETING ANTIBODY VRC34 FRAGMENT ANTIGEN BINDING DBREF 6NC3 A -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 B 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 H 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 L 2 211 PDB 6NC3 6NC3 2 211 DBREF 6NC3 C -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 I 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 O 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 T 2 211 PDB 6NC3 6NC3 2 211 DBREF 6NC3 D -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 J 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 P 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 U 2 211 PDB 6NC3 6NC3 2 211 DBREF 6NC3 E -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 K 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 Q 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 V 2 211 PDB 6NC3 6NC3 2 211 DBREF 6NC3 F -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 M 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 R 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 W 2 211 PDB 6NC3 6NC3 2 211 DBREF 6NC3 G -4 513 PDB 6NC3 6NC3 -4 513 DBREF 6NC3 N 512 664 PDB 6NC3 6NC3 512 664 DBREF 6NC3 S 1 213 PDB 6NC3 6NC3 1 213 DBREF 6NC3 X 2 211 PDB 6NC3 6NC3 2 211 SEQRES 1 A 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 A 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 A 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 A 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 A 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 A 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 A 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 A 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 A 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 A 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 A 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 A 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 A 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 A 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 A 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 A 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 A 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 A 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 A 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 A 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 A 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 A 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 A 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 A 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 A 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 A 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 A 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 A 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 A 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 A 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 A 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 A 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 A 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 A 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 A 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 A 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 A 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 A 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 A 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 A 512 ARG ARG ARG ARG ARG SEQRES 1 B 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 B 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 B 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 B 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 B 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 B 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 B 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 B 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 H 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 H 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 H 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 H 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 H 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 H 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 H 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 H 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 H 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 H 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 H 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 H 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 H 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 H 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 H 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 H 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 H 222 PRO SEQRES 1 L 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 L 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 L 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 L 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 L 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 L 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 L 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 L 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 L 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 L 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 L 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 L 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 L 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 L 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 L 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 L 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 L 210 ASN ALA SEQRES 1 C 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 C 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 C 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 C 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 C 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 C 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 C 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 C 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 C 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 C 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 C 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 C 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 C 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 C 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 C 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 C 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 C 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 C 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 C 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 C 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 C 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 C 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 C 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 C 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 C 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 C 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 C 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 C 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 C 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 C 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 C 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 C 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 C 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 C 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 C 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 C 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 C 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 C 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 C 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 C 512 ARG ARG ARG ARG ARG SEQRES 1 I 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 I 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 I 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 I 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 I 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 I 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 I 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 I 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 I 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 I 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 I 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 I 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 O 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 O 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 O 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 O 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 O 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 O 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 O 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 O 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 O 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 O 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 O 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 O 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 O 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 O 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 O 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 O 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 O 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 O 222 PRO SEQRES 1 T 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 T 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 T 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 T 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 T 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 T 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 T 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 T 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 T 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 T 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 T 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 T 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 T 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 T 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 T 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 T 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 T 210 ASN ALA SEQRES 1 D 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 D 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 D 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 D 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 D 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 D 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 D 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 D 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 D 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 D 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 D 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 D 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 D 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 D 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 D 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 D 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 D 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 D 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 D 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 D 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 D 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 D 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 D 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 D 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 D 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 D 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 D 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 D 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 D 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 D 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 D 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 D 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 D 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 D 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 D 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 D 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 D 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 D 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 D 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 D 512 ARG ARG ARG ARG ARG SEQRES 1 J 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 J 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 J 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 J 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 J 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 J 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 J 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 J 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 J 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 J 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 J 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 J 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 P 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 P 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 P 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 P 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 P 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 P 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 P 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 P 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 P 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 P 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 P 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 P 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 P 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 P 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 P 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 P 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 P 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 P 222 PRO SEQRES 1 U 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 U 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 U 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 U 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 U 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 U 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 U 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 U 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 U 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 U 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 U 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 U 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 U 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 U 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 U 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 U 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 U 210 ASN ALA SEQRES 1 E 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 E 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 E 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 E 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 E 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 E 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 E 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 E 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 E 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 E 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 E 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 E 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 E 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 E 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 E 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 E 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 E 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 E 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 E 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 E 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 E 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 E 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 E 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 E 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 E 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 E 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 E 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 E 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 E 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 E 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 E 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 E 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 E 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 E 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 E 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 E 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 E 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 E 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 E 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 E 512 ARG ARG ARG ARG ARG SEQRES 1 K 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 K 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 K 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 K 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 K 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 K 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 K 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 K 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 K 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 K 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 K 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 K 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 Q 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 Q 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 Q 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 Q 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 Q 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 Q 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 Q 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 Q 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 Q 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 Q 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 Q 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 Q 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 Q 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 Q 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 Q 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 Q 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 Q 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 Q 222 PRO SEQRES 1 V 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 V 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 V 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 V 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 V 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 V 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 V 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 V 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 V 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 V 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 V 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 V 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 V 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 V 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 V 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 V 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 V 210 ASN ALA SEQRES 1 F 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 F 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 F 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 F 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 F 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 F 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 F 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 F 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 F 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 F 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 F 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 F 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 F 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 F 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 F 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 F 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 F 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 F 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 F 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 F 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 F 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 F 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 F 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 F 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 F 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 F 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 F 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 F 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 F 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 F 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 F 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 F 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 F 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 F 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 F 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 F 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 F 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 F 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 F 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 F 512 ARG ARG ARG ARG ARG SEQRES 1 M 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 M 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 M 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 M 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 M 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 M 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 M 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 M 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 M 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 M 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 M 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 M 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 R 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 R 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 R 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 R 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 R 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 R 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 R 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 R 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 R 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 R 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 R 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 R 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 R 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 R 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 R 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 R 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 R 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 R 222 PRO SEQRES 1 W 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 W 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 W 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 W 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 W 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 W 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 W 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 W 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 W 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 W 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 W 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 W 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 W 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 W 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 W 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 W 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 W 210 ASN ALA SEQRES 1 G 512 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 G 512 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 G 512 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU GLN LEU SEQRES 4 G 512 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS GLU SEQRES 5 G 512 ALA THR THR THR LEU PHE CYS ALA SER ASP ALA ARG ALA SEQRES 6 G 512 TYR ASP THR GLU VAL ARG ASN VAL TRP ALA THR HIS ALA SEQRES 7 G 512 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU VAL VAL LEU SEQRES 8 G 512 GLU ASN VAL THR GLU ASN PHE ASN MET TRP LYS ASN ASN SEQRES 9 G 512 MET VAL GLU GLN MET HIS GLU ASP ILE ILE SER LEU TRP SEQRES 10 G 512 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 G 512 CYS VAL THR LEU ASN CYS THR ASP LEU ARG ASN ALA THR SEQRES 12 G 512 ASN THR ASN ALA THR ASN THR THR SER SER SER ARG GLY SEQRES 13 G 512 THR MET GLU GLY GLY GLU ILE LYS ASN CYS SER PHE ASN SEQRES 14 G 512 ILE THR THR SER MET ARG ASP LYS VAL GLN LYS GLU TYR SEQRES 15 G 512 ALA LEU PHE TYR LYS LEU ASP VAL VAL PRO ILE LYS ASN SEQRES 16 G 512 ASP ASN THR SER TYR ARG LEU ILE SER CYS ASN THR SER SEQRES 17 G 512 VAL ILE THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 18 G 512 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 19 G 512 LEU LYS CYS ASN ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 20 G 512 CYS THR ASN VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 21 G 512 ARG PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 22 G 512 LEU ALA GLU GLU GLU VAL VAL ILE ARG SER ALA ASN PHE SEQRES 23 G 512 THR ASP ASN ALA LYS ILE ILE ILE VAL GLN LEU ASN LYS SEQRES 24 G 512 SER VAL GLU ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 25 G 512 ARG LYS SER ILE HIS ILE GLY PRO GLY ARG TRP PHE TYR SEQRES 26 G 512 THR THR GLY GLU ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 27 G 512 CYS ASN ILE SER GLY THR LYS TRP ASN ASP THR LEU LYS SEQRES 28 G 512 GLN ILE VAL VAL LYS LEU LYS GLU GLN PHE GLY ASN LYS SEQRES 29 G 512 THR ILE VAL PHE ASN HIS SER SER GLY GLY ASP PRO GLU SEQRES 30 G 512 ILE VAL MET HIS SER PHE ASN CYS GLY GLY GLU PHE PHE SEQRES 31 G 512 TYR CYS ASN SER THR GLN LEU PHE ASN SER THR TRP ASN SEQRES 32 G 512 ASP GLY SER ASN TYR THR GLY THR ILE VAL LEU PRO CYS SEQRES 33 G 512 ARG ILE LYS GLN ILE VAL ASN MET TRP GLN GLU VAL GLY SEQRES 34 G 512 LYS ALA MET TYR ALA PRO PRO ILE LYS GLY GLN ILE ARG SEQRES 35 G 512 CYS SER SER ASN ILE THR GLY LEU ILE LEU ILE ARG ASP SEQRES 36 G 512 GLY GLY LYS ASN ARG SER GLU ASN THR GLU ILE PHE ARG SEQRES 37 G 512 PRO GLY GLY GLY ASP MET ARG ASP ASN TRP ARG SER GLU SEQRES 38 G 512 LEU TYR LYS TYR LYS VAL VAL LYS ILE GLU PRO LEU GLY SEQRES 39 G 512 ILE ALA PRO THR LYS CYS LYS ARG ARG VAL VAL GLN ARG SEQRES 40 G 512 ARG ARG ARG ARG ARG SEQRES 1 N 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 N 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 N 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 N 153 GLN GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 N 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 N 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU LYS ASP SEQRES 7 N 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 N 153 ILE CYS CYS THR ALA VAL PRO TRP ASN THR SER TRP SER SEQRES 9 N 153 ASN LYS SER TYR ASN GLN ILE TRP ASN ASN MET THR TRP SEQRES 10 N 153 MET GLU TRP GLU ARG GLU ILE ASP ASN TYR THR SER LEU SEQRES 11 N 153 ILE TYR THR LEU ILE GLU ASP SER GLN ASN GLN GLN GLU SEQRES 12 N 153 LYS ASN GLU GLN GLU LEU LEU GLU LEU ASP SEQRES 1 S 222 GLN GLU VAL LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 S 222 PRO GLY ALA SER VAL LYS VAL SER CYS ARG ALA PHE GLY SEQRES 3 S 222 TYR THR PHE THR GLY ASN ALA LEU HIS TRP VAL ARG GLN SEQRES 4 S 222 ALA PRO GLY GLN GLY LEU GLU TRP LEU GLY TRP ILE ASN SEQRES 5 S 222 PRO HIS SER GLY ASP THR THR THR SER GLN LYS PHE GLN SEQRES 6 S 222 GLY ARG VAL TYR MET THR ARG ASP LYS SER ILE ASN THR SEQRES 7 S 222 ALA PHE LEU ASP VAL THR ARG LEU THR SER ASP ASP THR SEQRES 8 S 222 GLY ILE TYR TYR CYS ALA ARG ASP LYS TYR TYR GLY ASN SEQRES 9 S 222 GLU ALA VAL GLY MET ASP VAL TRP GLY GLN GLY THR SER SEQRES 10 S 222 VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL SEQRES 11 S 222 PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY SEQRES 12 S 222 THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO SEQRES 13 S 222 GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SEQRES 14 S 222 SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER SEQRES 15 S 222 GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER SEQRES 16 S 222 SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN SEQRES 17 S 222 HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU SEQRES 18 S 222 PRO SEQRES 1 X 210 ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SER SEQRES 2 X 210 VAL GLY ASP LYS VAL THR ILE THR CYS ARG ALA SER GLN SEQRES 3 X 210 GLY VAL ARG ASN GLU LEU ALA TRP TYR GLN GLN LYS PRO SEQRES 4 X 210 GLY LYS ALA PRO ASN LEU LEU ILE TYR TYR ALA SER THR SEQRES 5 X 210 LEU GLN SER GLY VAL PRO SER ARG PHE SER ALA THR GLY SEQRES 6 X 210 SER GLY THR HIS PHE THR LEU THR VAL SER SER LEU GLN SEQRES 7 X 210 PRO GLU ASP PHE ALA THR TYR PHE CYS GLN HIS MET SER SEQRES 8 X 210 SER TYR PRO LEU THR PHE GLY GLY GLY THR LYS VAL GLU SEQRES 9 X 210 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 X 210 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 X 210 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 X 210 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 X 210 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 X 210 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 X 210 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 X 210 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 X 210 ASN ALA HET NAG A 608 14 HET NAG A 620 14 HET NAG A 627 14 HET NAG C 608 14 HET NAG C 620 14 HET NAG C 627 14 HET NAG D 608 14 HET NAG D 620 14 HET NAG D 627 14 HET NAG E 608 14 HET NAG E 620 14 HET NAG E 627 14 HET NAG F 608 14 HET NAG F 620 14 HET NAG F 627 14 HET NAG G 608 14 HET NAG G 620 14 HET NAG G 627 14 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET MAN Y 4 11 HET MAN Y 5 11 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET BMA a 3 11 HET MAN a 4 11 HET NAG b 1 14 HET NAG b 2 14 HET BMA b 3 11 HET MAN b 4 11 HET MAN b 5 11 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET MAN f 4 11 HET MAN f 5 11 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET BMA h 3 11 HET MAN h 4 11 HET NAG i 1 14 HET NAG i 2 14 HET BMA i 3 11 HET MAN i 4 11 HET MAN i 5 11 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET NAG l 1 14 HET NAG l 2 14 HET BMA l 3 11 HET NAG m 1 14 HET NAG m 2 14 HET BMA m 3 11 HET MAN m 4 11 HET MAN m 5 11 HET NAG n 1 14 HET NAG n 2 14 HET NAG o 1 14 HET NAG o 2 14 HET BMA o 3 11 HET MAN o 4 11 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET MAN p 4 11 HET MAN p 5 11 HET NAG q 1 14 HET NAG q 2 14 HET NAG r 1 14 HET NAG r 2 14 HET BMA r 3 11 HET NAG s 1 14 HET NAG s 2 14 HET BMA s 3 11 HET NAG t 1 14 HET NAG t 2 14 HET BMA t 3 11 HET MAN t 4 11 HET MAN t 5 11 HET NAG u 1 14 HET NAG u 2 14 HET NAG v 1 14 HET NAG v 2 14 HET BMA v 3 11 HET MAN v 4 11 HET NAG w 1 14 HET NAG w 2 14 HET BMA w 3 11 HET MAN w 4 11 HET MAN w 5 11 HET NAG x 1 14 HET NAG x 2 14 HET NAG y 1 14 HET NAG y 2 14 HET BMA y 3 11 HET NAG z 1 14 HET NAG z 2 14 HET BMA z 3 11 HET NAG 0 1 14 HET NAG 0 2 14 HET BMA 0 3 11 HET MAN 0 4 11 HET MAN 0 5 11 HET NAG 1 1 14 HET NAG 1 2 14 HET NAG 2 1 14 HET NAG 2 2 14 HET BMA 2 3 11 HET MAN 2 4 11 HET NAG 3 1 14 HET NAG 3 2 14 HET BMA 3 3 11 HET MAN 3 4 11 HET MAN 3 5 11 HET NAG 4 1 14 HET NAG 4 2 14 HET NAG 5 1 14 HET NAG 5 2 14 HET BMA 5 3 11 HET NAG 6 1 14 HET NAG 6 2 14 HET BMA 6 3 11 HET NAG 7 1 14 HET NAG 7 2 14 HET BMA 7 3 11 HET MAN 7 4 11 HET MAN 7 5 11 HET NAG 8 1 14 HET NAG 8 2 14 HET NAG 9 1 14 HET NAG 9 2 14 HET BMA 9 3 11 HET MAN 9 4 11 HET NAG AA 1 14 HET NAG AA 2 14 HET BMA AA 3 11 HET MAN AA 4 11 HET MAN AA 5 11 HET NAG BA 1 14 HET NAG BA 2 14 HET NAG CA 1 14 HET NAG CA 2 14 HET BMA CA 3 11 HET NAG DA 1 14 HET NAG DA 2 14 HET BMA DA 3 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 25 NAG 102(C8 H15 N O6) FORMUL 43 BMA 30(C6 H12 O6) FORMUL 43 MAN 30(C6 H12 O6) HELIX 1 AA1 ARG A 59 THR A 63 5 5 HELIX 2 AA2 TRP A 96 ASN A 98 5 3 HELIX 3 AA3 ASN A 99 LEU A 116 1 18 HELIX 4 AA4 THR A 123 CYS A 126 5 4 HELIX 5 AA5 SER A 334 GLY A 354 1 21 HELIX 6 AA6 ASP A 368 MET A 373 1 6 HELIX 7 AA7 THR A 388 ASN A 392 5 5 HELIX 8 AA8 ASP A 474 TYR A 484 1 11 HELIX 9 AA9 THR B 529 SER B 534 1 6 HELIX 10 AB1 THR B 536 GLN B 543 1 8 HELIX 11 AB2 VAL B 570 GLY B 597 1 28 HELIX 12 AB3 SER B 618 ASN B 624 1 7 HELIX 13 AB4 THR B 627 ARG B 633 1 7 HELIX 14 AB5 GLU B 634 ASN B 637 5 4 HELIX 15 AB6 TYR B 638 SER B 649 1 12 HELIX 16 AB7 GLN B 650 GLU B 662 1 13 HELIX 17 AB8 THR H 28 ASN H 32 5 5 HELIX 18 AB9 GLN H 61 GLN H 64 5 4 HELIX 19 AC1 LYS H 73 ILE H 75 5 3 HELIX 20 AC2 THR H 83 THR H 87 5 5 HELIX 21 AC3 TYR H 97 GLU H 100A 5 5 HELIX 22 AC4 GLN L 79 PHE L 83 5 5 HELIX 23 AC5 ARG C 59 THR C 63 5 5 HELIX 24 AC6 TRP C 96 ASN C 98 5 3 HELIX 25 AC7 ASN C 99 LEU C 116 1 18 HELIX 26 AC8 THR C 123 CYS C 126 5 4 HELIX 27 AC9 SER C 334 GLY C 354 1 21 HELIX 28 AD1 ASP C 368 MET C 373 1 6 HELIX 29 AD2 THR C 388 ASN C 392 5 5 HELIX 30 AD3 ASP C 474 TYR C 484 1 11 HELIX 31 AD4 THR I 529 SER I 534 1 6 HELIX 32 AD5 THR I 536 GLN I 543 1 8 HELIX 33 AD6 VAL I 570 GLY I 597 1 28 HELIX 34 AD7 SER I 618 ASN I 624 1 7 HELIX 35 AD8 THR I 627 ARG I 633 1 7 HELIX 36 AD9 GLU I 634 ASN I 637 5 4 HELIX 37 AE1 TYR I 638 SER I 649 1 12 HELIX 38 AE2 GLN I 650 GLU I 662 1 13 HELIX 39 AE3 THR O 28 ASN O 32 5 5 HELIX 40 AE4 GLN O 61 GLN O 64 5 4 HELIX 41 AE5 LYS O 73 ILE O 75 5 3 HELIX 42 AE6 THR O 83 THR O 87 5 5 HELIX 43 AE7 TYR O 97 GLU O 100A 5 5 HELIX 44 AE8 GLN T 79 PHE T 83 5 5 HELIX 45 AE9 ARG D 59 THR D 63 5 5 HELIX 46 AF1 TRP D 96 ASN D 98 5 3 HELIX 47 AF2 ASN D 99 LEU D 116 1 18 HELIX 48 AF3 THR D 123 CYS D 126 5 4 HELIX 49 AF4 SER D 334 GLY D 354 1 21 HELIX 50 AF5 ASP D 368 MET D 373 1 6 HELIX 51 AF6 THR D 388 ASN D 392 5 5 HELIX 52 AF7 ASP D 474 TYR D 484 1 11 HELIX 53 AF8 THR J 529 SER J 534 1 6 HELIX 54 AF9 THR J 536 GLN J 543 1 8 HELIX 55 AG1 VAL J 570 GLY J 597 1 28 HELIX 56 AG2 SER J 618 ASN J 624 1 7 HELIX 57 AG3 THR J 627 ARG J 633 1 7 HELIX 58 AG4 GLU J 634 ASN J 637 5 4 HELIX 59 AG5 TYR J 638 SER J 649 1 12 HELIX 60 AG6 GLN J 650 GLU J 662 1 13 HELIX 61 AG7 THR P 28 ASN P 32 5 5 HELIX 62 AG8 GLN P 61 GLN P 64 5 4 HELIX 63 AG9 LYS P 73 ILE P 75 5 3 HELIX 64 AH1 THR P 83 THR P 87 5 5 HELIX 65 AH2 TYR P 97 GLU P 100A 5 5 HELIX 66 AH3 GLN U 79 PHE U 83 5 5 HELIX 67 AH4 ARG E 59 THR E 63 5 5 HELIX 68 AH5 TRP E 96 ASN E 98 5 3 HELIX 69 AH6 ASN E 99 LEU E 116 1 18 HELIX 70 AH7 THR E 123 CYS E 126 5 4 HELIX 71 AH8 SER E 334 GLY E 354 1 21 HELIX 72 AH9 ASP E 368 MET E 373 1 6 HELIX 73 AI1 THR E 388 ASN E 392 5 5 HELIX 74 AI2 ASP E 474 TYR E 484 1 11 HELIX 75 AI3 THR K 529 SER K 534 1 6 HELIX 76 AI4 THR K 536 GLN K 543 1 8 HELIX 77 AI5 VAL K 570 GLY K 597 1 28 HELIX 78 AI6 SER K 618 ASN K 624 1 7 HELIX 79 AI7 THR K 627 ARG K 633 1 7 HELIX 80 AI8 GLU K 634 ASN K 637 5 4 HELIX 81 AI9 TYR K 638 SER K 649 1 12 HELIX 82 AJ1 GLN K 650 GLU K 662 1 13 HELIX 83 AJ2 THR Q 28 ASN Q 32 5 5 HELIX 84 AJ3 GLN Q 61 GLN Q 64 5 4 HELIX 85 AJ4 LYS Q 73 ILE Q 75 5 3 HELIX 86 AJ5 THR Q 83 THR Q 87 5 5 HELIX 87 AJ6 TYR Q 97 GLU Q 100A 5 5 HELIX 88 AJ7 GLN V 79 PHE V 83 5 5 HELIX 89 AJ8 ARG F 59 THR F 63 5 5 HELIX 90 AJ9 TRP F 96 ASN F 98 5 3 HELIX 91 AK1 ASN F 99 LEU F 116 1 18 HELIX 92 AK2 THR F 123 CYS F 126 5 4 HELIX 93 AK3 SER F 334 GLY F 354 1 21 HELIX 94 AK4 ASP F 368 MET F 373 1 6 HELIX 95 AK5 THR F 388 ASN F 392 5 5 HELIX 96 AK6 ASP F 474 TYR F 484 1 11 HELIX 97 AK7 THR M 529 SER M 534 1 6 HELIX 98 AK8 THR M 536 GLN M 543 1 8 HELIX 99 AK9 VAL M 570 GLY M 597 1 28 HELIX 100 AL1 SER M 618 ASN M 624 1 7 HELIX 101 AL2 THR M 627 ARG M 633 1 7 HELIX 102 AL3 GLU M 634 ASN M 637 5 4 HELIX 103 AL4 TYR M 638 SER M 649 1 12 HELIX 104 AL5 GLN M 650 GLU M 662 1 13 HELIX 105 AL6 THR R 28 ASN R 32 5 5 HELIX 106 AL7 GLN R 61 GLN R 64 5 4 HELIX 107 AL8 LYS R 73 ILE R 75 5 3 HELIX 108 AL9 THR R 83 THR R 87 5 5 HELIX 109 AM1 TYR R 97 GLU R 100A 5 5 HELIX 110 AM2 GLN W 79 PHE W 83 5 5 HELIX 111 AM3 ARG G 59 THR G 63 5 5 HELIX 112 AM4 TRP G 96 ASN G 98 5 3 HELIX 113 AM5 ASN G 99 LEU G 116 1 18 HELIX 114 AM6 THR G 123 CYS G 126 5 4 HELIX 115 AM7 SER G 334 GLY G 354 1 21 HELIX 116 AM8 ASP G 368 MET G 373 1 6 HELIX 117 AM9 THR G 388 ASN G 392 5 5 HELIX 118 AN1 ASP G 474 TYR G 484 1 11 HELIX 119 AN2 THR N 529 SER N 534 1 6 HELIX 120 AN3 THR N 536 GLN N 543 1 8 HELIX 121 AN4 VAL N 570 GLY N 597 1 28 HELIX 122 AN5 SER N 618 ASN N 624 1 7 HELIX 123 AN6 THR N 627 ARG N 633 1 7 HELIX 124 AN7 GLU N 634 ASN N 637 5 4 HELIX 125 AN8 TYR N 638 SER N 649 1 12 HELIX 126 AN9 GLN N 650 GLU N 662 1 13 HELIX 127 AO1 THR S 28 ASN S 32 5 5 HELIX 128 AO2 GLN S 61 GLN S 64 5 4 HELIX 129 AO3 LYS S 73 ILE S 75 5 3 HELIX 130 AO4 THR S 83 THR S 87 5 5 HELIX 131 AO5 TYR S 97 GLU S 100A 5 5 HELIX 132 AO6 GLN X 79 PHE X 83 5 5 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TYR A 39 O GLY A 495 SHEET 3 AA1 3 ILE B 603 PRO B 609 -1 O CYS B 604 N VAL A 38 SHEET 1 AA2 5 TRP A 45 GLU A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 PHE A 223 CYS A 228 -1 N LEU A 226 O LYS A 487 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O VAL A 245 N ILE A 225 SHEET 5 AA2 5 GLU A 83 VAL A 85 -1 N VAL A 84 O THR A 244 SHEET 1 AA3 4 VAL A 75 PRO A 76 0 SHEET 2 AA3 4 PHE A 53 SER A 56 1 N SER A 56 O VAL A 75 SHEET 3 AA3 4 ILE A 215 CYS A 218 -1 O CYS A 218 N PHE A 53 SHEET 4 AA3 4 CYS A 247 ILE A 251 -1 O ILE A 251 N ILE A 215 SHEET 1 AA4 2 GLU A 91 ASN A 94 0 SHEET 2 AA4 2 THR A 236 CYS A 239 -1 O GLY A 237 N PHE A 93 SHEET 1 AA5 4 VAL A 120 LYS A 121 0 SHEET 2 AA5 4 ILE A 201 GLN A 203 -1 O GLN A 203 N VAL A 120 SHEET 3 AA5 4 ALA A 433 TYR A 435 1 O TYR A 435 N THR A 202 SHEET 4 AA5 4 ILE A 423 VAL A 424 -1 N VAL A 424 O MET A 434 SHEET 1 AA6 5 GLN A 170 TYR A 177 0 SHEET 2 AA6 5 ILE A 154 ILE A 161 -1 N LYS A 155 O PHE A 176 SHEET 3 AA6 5 LEU A 129 ASP A 133 -1 N ASN A 130 O SER A 158 SHEET 4 AA6 5 SER A 190 LEU A 193 -1 O TYR A 191 N LEU A 129 SHEET 5 AA6 5 VAL A 181 PRO A 183 -1 N VAL A 182 O ARG A 192 SHEET 1 AA7 6 VAL A 271 SER A 274 0 SHEET 2 AA7 6 ILE A 284 GLY A 312 -1 O GLN A 287 N VAL A 271 SHEET 3 AA7 6 ALA A 329 ILE A 333 -1 O ASN A 332 N ASN A 295 SHEET 4 AA7 6 VAL A 415 ILE A 420 -1 O CYS A 418 N ALA A 329 SHEET 5 AA7 6 GLU A 381 CYS A 385 -1 N TYR A 384 O ARG A 419 SHEET 6 AA7 6 HIS A 374 CYS A 378 -1 N HIS A 374 O CYS A 385 SHEET 1 AA8 6 LEU A 260 LEU A 261 0 SHEET 2 AA8 6 GLY A 441 ARG A 456 -1 O THR A 450 N LEU A 260 SHEET 3 AA8 6 PHE A 468 PRO A 470 -1 O ARG A 469 N ILE A 455 SHEET 4 AA8 6 GLY A 441 ARG A 456 -1 N ILE A 455 O ARG A 469 SHEET 5 AA8 6 ILE A 284 GLY A 312 -1 N VAL A 286 O LEU A 452 SHEET 6 AA8 6 ARG A 315 ILE A 323 -1 O PHE A 317 N ILE A 307 SHEET 1 AA9 4 VAL H 3 GLN H 6 0 SHEET 2 AA9 4 VAL H 18 PHE H 25 -1 O ARG H 23 N VAL H 5 SHEET 3 AA9 4 THR H 77 VAL H 82 -1 O LEU H 80 N VAL H 20 SHEET 4 AA9 4 VAL H 67 ASP H 72 -1 N TYR H 68 O ASP H 81 SHEET 1 AB1 6 GLU H 10 VAL H 11 0 SHEET 2 AB1 6 THR H 107 THR H 110 1 O THR H 110 N GLU H 10 SHEET 3 AB1 6 GLY H 88 ASP H 95 -1 N TYR H 90 O THR H 107 SHEET 4 AB1 6 LEU H 34 GLN H 39 -1 N HIS H 35 O ALA H 93 SHEET 5 AB1 6 GLU H 46 ILE H 51 -1 O GLY H 49 N TRP H 36 SHEET 6 AB1 6 THR H 57 THR H 59 -1 O THR H 58 N TRP H 50 SHEET 1 AB2 4 GLU H 10 VAL H 11 0 SHEET 2 AB2 4 THR H 107 THR H 110 1 O THR H 110 N GLU H 10 SHEET 3 AB2 4 GLY H 88 ASP H 95 -1 N TYR H 90 O THR H 107 SHEET 4 AB2 4 MET H 100E TRP H 103 -1 O VAL H 102 N ARG H 94 SHEET 1 AB3 4 LEU L 4 GLN L 6 0 SHEET 2 AB3 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AB3 4 HIS L 70 VAL L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AB3 4 PHE L 62 SER L 67 -1 N SER L 63 O THR L 74 SHEET 1 AB4 6 PHE L 10 ALA L 13 0 SHEET 2 AB4 6 THR L 102 ILE L 106 1 O GLU L 105 N ALA L 13 SHEET 3 AB4 6 THR L 85 HIS L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AB4 6 LEU L 33 GLN L 38 -1 N TYR L 36 O PHE L 87 SHEET 5 AB4 6 ASN L 45 TYR L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AB4 6 THR L 53 LEU L 54 -1 O THR L 53 N TYR L 49 SHEET 1 AB5 3 LEU C 494 THR C 499 0 SHEET 2 AB5 3 TRP C 35 TYR C 40 -1 N TYR C 39 O GLY C 495 SHEET 3 AB5 3 ILE I 603 PRO I 609 -1 O CYS I 604 N VAL C 38 SHEET 1 AB6 5 TRP C 45 GLU C 47 0 SHEET 2 AB6 5 TYR C 486 ILE C 491 -1 O LYS C 490 N LYS C 46 SHEET 3 AB6 5 PHE C 223 CYS C 228 -1 N LEU C 226 O LYS C 487 SHEET 4 AB6 5 VAL C 242 VAL C 245 -1 O VAL C 245 N ILE C 225 SHEET 5 AB6 5 GLU C 83 VAL C 85 -1 N VAL C 84 O THR C 244 SHEET 1 AB7 4 VAL C 75 PRO C 76 0 SHEET 2 AB7 4 PHE C 53 SER C 56 1 N SER C 56 O VAL C 75 SHEET 3 AB7 4 ILE C 215 CYS C 218 -1 O CYS C 218 N PHE C 53 SHEET 4 AB7 4 CYS C 247 ILE C 251 -1 O ILE C 251 N ILE C 215 SHEET 1 AB8 2 GLU C 91 ASN C 94 0 SHEET 2 AB8 2 THR C 236 CYS C 239 -1 O GLY C 237 N PHE C 93 SHEET 1 AB9 4 VAL C 120 LYS C 121 0 SHEET 2 AB9 4 ILE C 201 GLN C 203 -1 O GLN C 203 N VAL C 120 SHEET 3 AB9 4 ALA C 433 TYR C 435 1 O TYR C 435 N THR C 202 SHEET 4 AB9 4 ILE C 423 VAL C 424 -1 N VAL C 424 O MET C 434 SHEET 1 AC1 5 GLN C 170 TYR C 177 0 SHEET 2 AC1 5 ILE C 154 ILE C 161 -1 N LYS C 155 O PHE C 176 SHEET 3 AC1 5 LEU C 129 ASP C 133 -1 N ASN C 130 O SER C 158 SHEET 4 AC1 5 SER C 190 LEU C 193 -1 O TYR C 191 N LEU C 129 SHEET 5 AC1 5 VAL C 181 PRO C 183 -1 N VAL C 182 O ARG C 192 SHEET 1 AC2 6 VAL C 271 SER C 274 0 SHEET 2 AC2 6 ILE C 284 GLY C 312 -1 O GLN C 287 N VAL C 271 SHEET 3 AC2 6 ALA C 329 ILE C 333 -1 O ASN C 332 N ASN C 295 SHEET 4 AC2 6 VAL C 415 ILE C 420 -1 O CYS C 418 N ALA C 329 SHEET 5 AC2 6 GLU C 381 CYS C 385 -1 N TYR C 384 O ARG C 419 SHEET 6 AC2 6 HIS C 374 CYS C 378 -1 N HIS C 374 O CYS C 385 SHEET 1 AC3 6 LEU C 260 LEU C 261 0 SHEET 2 AC3 6 GLY C 441 ARG C 456 -1 O THR C 450 N LEU C 260 SHEET 3 AC3 6 PHE C 468 PRO C 470 -1 O ARG C 469 N ILE C 455 SHEET 4 AC3 6 GLY C 441 ARG C 456 -1 N ILE C 455 O ARG C 469 SHEET 5 AC3 6 ILE C 284 GLY C 312 -1 N VAL C 286 O LEU C 452 SHEET 6 AC3 6 ARG C 315 ILE C 323 -1 O PHE C 317 N ILE C 307 SHEET 1 AC4 4 VAL O 3 GLN O 6 0 SHEET 2 AC4 4 VAL O 18 PHE O 25 -1 O ARG O 23 N VAL O 5 SHEET 3 AC4 4 THR O 77 VAL O 82 -1 O LEU O 80 N VAL O 20 SHEET 4 AC4 4 VAL O 67 ASP O 72 -1 N TYR O 68 O ASP O 81 SHEET 1 AC5 6 GLU O 10 VAL O 11 0 SHEET 2 AC5 6 THR O 107 THR O 110 1 O THR O 110 N GLU O 10 SHEET 3 AC5 6 GLY O 88 ASP O 95 -1 N TYR O 90 O THR O 107 SHEET 4 AC5 6 LEU O 34 GLN O 39 -1 N HIS O 35 O ALA O 93 SHEET 5 AC5 6 GLU O 46 ILE O 51 -1 O GLY O 49 N TRP O 36 SHEET 6 AC5 6 THR O 57 THR O 59 -1 O THR O 58 N TRP O 50 SHEET 1 AC6 4 GLU O 10 VAL O 11 0 SHEET 2 AC6 4 THR O 107 THR O 110 1 O THR O 110 N GLU O 10 SHEET 3 AC6 4 GLY O 88 ASP O 95 -1 N TYR O 90 O THR O 107 SHEET 4 AC6 4 MET O 100E TRP O 103 -1 O VAL O 102 N ARG O 94 SHEET 1 AC7 4 LEU T 4 GLN T 6 0 SHEET 2 AC7 4 VAL T 19 ALA T 25 -1 O ARG T 24 N THR T 5 SHEET 3 AC7 4 HIS T 70 VAL T 75 -1 O PHE T 71 N CYS T 23 SHEET 4 AC7 4 PHE T 62 SER T 67 -1 N SER T 63 O THR T 74 SHEET 1 AC8 6 PHE T 10 ALA T 13 0 SHEET 2 AC8 6 THR T 102 ILE T 106 1 O GLU T 105 N ALA T 13 SHEET 3 AC8 6 THR T 85 HIS T 90 -1 N TYR T 86 O THR T 102 SHEET 4 AC8 6 LEU T 33 GLN T 38 -1 N TYR T 36 O PHE T 87 SHEET 5 AC8 6 ASN T 45 TYR T 49 -1 O LEU T 47 N TRP T 35 SHEET 6 AC8 6 THR T 53 LEU T 54 -1 O THR T 53 N TYR T 49 SHEET 1 AC9 3 LEU D 494 THR D 499 0 SHEET 2 AC9 3 TRP D 35 TYR D 40 -1 N TYR D 39 O GLY D 495 SHEET 3 AC9 3 ILE J 603 PRO J 609 -1 O CYS J 604 N VAL D 38 SHEET 1 AD1 5 TRP D 45 GLU D 47 0 SHEET 2 AD1 5 TYR D 486 ILE D 491 -1 O LYS D 490 N LYS D 46 SHEET 3 AD1 5 PHE D 223 CYS D 228 -1 N LEU D 226 O LYS D 487 SHEET 4 AD1 5 VAL D 242 VAL D 245 -1 O VAL D 245 N ILE D 225 SHEET 5 AD1 5 GLU D 83 VAL D 85 -1 N VAL D 84 O THR D 244 SHEET 1 AD2 4 VAL D 75 PRO D 76 0 SHEET 2 AD2 4 PHE D 53 SER D 56 1 N SER D 56 O VAL D 75 SHEET 3 AD2 4 ILE D 215 CYS D 218 -1 O CYS D 218 N PHE D 53 SHEET 4 AD2 4 CYS D 247 ILE D 251 -1 O ILE D 251 N ILE D 215 SHEET 1 AD3 2 GLU D 91 ASN D 94 0 SHEET 2 AD3 2 THR D 236 CYS D 239 -1 O GLY D 237 N PHE D 93 SHEET 1 AD4 4 VAL D 120 LYS D 121 0 SHEET 2 AD4 4 ILE D 201 GLN D 203 -1 O GLN D 203 N VAL D 120 SHEET 3 AD4 4 ALA D 433 TYR D 435 1 O TYR D 435 N THR D 202 SHEET 4 AD4 4 ILE D 423 VAL D 424 -1 N VAL D 424 O MET D 434 SHEET 1 AD5 5 GLN D 170 TYR D 177 0 SHEET 2 AD5 5 ILE D 154 ILE D 161 -1 N LYS D 155 O PHE D 176 SHEET 3 AD5 5 LEU D 129 ASP D 133 -1 N ASN D 130 O SER D 158 SHEET 4 AD5 5 SER D 190 LEU D 193 -1 O TYR D 191 N LEU D 129 SHEET 5 AD5 5 VAL D 181 PRO D 183 -1 N VAL D 182 O ARG D 192 SHEET 1 AD6 6 VAL D 271 SER D 274 0 SHEET 2 AD6 6 ILE D 284 GLY D 312 -1 O GLN D 287 N VAL D 271 SHEET 3 AD6 6 ALA D 329 ILE D 333 -1 O ASN D 332 N ASN D 295 SHEET 4 AD6 6 VAL D 415 ILE D 420 -1 O CYS D 418 N ALA D 329 SHEET 5 AD6 6 GLU D 381 CYS D 385 -1 N TYR D 384 O ARG D 419 SHEET 6 AD6 6 HIS D 374 CYS D 378 -1 N HIS D 374 O CYS D 385 SHEET 1 AD7 6 LEU D 260 LEU D 261 0 SHEET 2 AD7 6 GLY D 441 ARG D 456 -1 O THR D 450 N LEU D 260 SHEET 3 AD7 6 PHE D 468 PRO D 470 -1 O ARG D 469 N ILE D 455 SHEET 4 AD7 6 GLY D 441 ARG D 456 -1 N ILE D 455 O ARG D 469 SHEET 5 AD7 6 ILE D 284 GLY D 312 -1 N VAL D 286 O LEU D 452 SHEET 6 AD7 6 ARG D 315 ILE D 323 -1 O PHE D 317 N ILE D 307 SHEET 1 AD8 4 VAL P 3 GLN P 6 0 SHEET 2 AD8 4 VAL P 18 PHE P 25 -1 O ARG P 23 N VAL P 5 SHEET 3 AD8 4 THR P 77 VAL P 82 -1 O LEU P 80 N VAL P 20 SHEET 4 AD8 4 VAL P 67 ASP P 72 -1 N TYR P 68 O ASP P 81 SHEET 1 AD9 6 GLU P 10 VAL P 11 0 SHEET 2 AD9 6 THR P 107 THR P 110 1 O THR P 110 N GLU P 10 SHEET 3 AD9 6 GLY P 88 ASP P 95 -1 N TYR P 90 O THR P 107 SHEET 4 AD9 6 LEU P 34 GLN P 39 -1 N HIS P 35 O ALA P 93 SHEET 5 AD9 6 GLU P 46 ILE P 51 -1 O GLY P 49 N TRP P 36 SHEET 6 AD9 6 THR P 57 THR P 59 -1 O THR P 58 N TRP P 50 SHEET 1 AE1 4 GLU P 10 VAL P 11 0 SHEET 2 AE1 4 THR P 107 THR P 110 1 O THR P 110 N GLU P 10 SHEET 3 AE1 4 GLY P 88 ASP P 95 -1 N TYR P 90 O THR P 107 SHEET 4 AE1 4 MET P 100E TRP P 103 -1 O VAL P 102 N ARG P 94 SHEET 1 AE2 4 LEU U 4 GLN U 6 0 SHEET 2 AE2 4 VAL U 19 ALA U 25 -1 O ARG U 24 N THR U 5 SHEET 3 AE2 4 HIS U 70 VAL U 75 -1 O PHE U 71 N CYS U 23 SHEET 4 AE2 4 PHE U 62 SER U 67 -1 N SER U 63 O THR U 74 SHEET 1 AE3 6 PHE U 10 ALA U 13 0 SHEET 2 AE3 6 THR U 102 ILE U 106 1 O GLU U 105 N ALA U 13 SHEET 3 AE3 6 THR U 85 HIS U 90 -1 N TYR U 86 O THR U 102 SHEET 4 AE3 6 LEU U 33 GLN U 38 -1 N TYR U 36 O PHE U 87 SHEET 5 AE3 6 ASN U 45 TYR U 49 -1 O LEU U 47 N TRP U 35 SHEET 6 AE3 6 THR U 53 LEU U 54 -1 O THR U 53 N TYR U 49 SHEET 1 AE4 3 LEU E 494 THR E 499 0 SHEET 2 AE4 3 TRP E 35 TYR E 40 -1 N TYR E 39 O GLY E 495 SHEET 3 AE4 3 ILE K 603 PRO K 609 -1 O CYS K 604 N VAL E 38 SHEET 1 AE5 5 TRP E 45 GLU E 47 0 SHEET 2 AE5 5 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AE5 5 PHE E 223 CYS E 228 -1 N LEU E 226 O LYS E 487 SHEET 4 AE5 5 VAL E 242 VAL E 245 -1 O VAL E 245 N ILE E 225 SHEET 5 AE5 5 GLU E 83 VAL E 85 -1 N VAL E 84 O THR E 244 SHEET 1 AE6 4 VAL E 75 PRO E 76 0 SHEET 2 AE6 4 PHE E 53 SER E 56 1 N SER E 56 O VAL E 75 SHEET 3 AE6 4 ILE E 215 CYS E 218 -1 O CYS E 218 N PHE E 53 SHEET 4 AE6 4 CYS E 247 ILE E 251 -1 O ILE E 251 N ILE E 215 SHEET 1 AE7 2 GLU E 91 ASN E 94 0 SHEET 2 AE7 2 THR E 236 CYS E 239 -1 O GLY E 237 N PHE E 93 SHEET 1 AE8 4 VAL E 120 LYS E 121 0 SHEET 2 AE8 4 ILE E 201 GLN E 203 -1 O GLN E 203 N VAL E 120 SHEET 3 AE8 4 ALA E 433 TYR E 435 1 O TYR E 435 N THR E 202 SHEET 4 AE8 4 ILE E 423 VAL E 424 -1 N VAL E 424 O MET E 434 SHEET 1 AE9 5 GLN E 170 TYR E 177 0 SHEET 2 AE9 5 ILE E 154 ILE E 161 -1 N LYS E 155 O PHE E 176 SHEET 3 AE9 5 LEU E 129 ASP E 133 -1 N ASN E 130 O SER E 158 SHEET 4 AE9 5 SER E 190 LEU E 193 -1 O TYR E 191 N LEU E 129 SHEET 5 AE9 5 VAL E 181 PRO E 183 -1 N VAL E 182 O ARG E 192 SHEET 1 AF1 6 VAL E 271 SER E 274 0 SHEET 2 AF1 6 ILE E 284 GLY E 312 -1 O GLN E 287 N VAL E 271 SHEET 3 AF1 6 ALA E 329 ILE E 333 -1 O ASN E 332 N ASN E 295 SHEET 4 AF1 6 VAL E 415 ILE E 420 -1 O CYS E 418 N ALA E 329 SHEET 5 AF1 6 GLU E 381 CYS E 385 -1 N TYR E 384 O ARG E 419 SHEET 6 AF1 6 HIS E 374 CYS E 378 -1 N HIS E 374 O CYS E 385 SHEET 1 AF2 6 LEU E 260 LEU E 261 0 SHEET 2 AF2 6 GLY E 441 ARG E 456 -1 O THR E 450 N LEU E 260 SHEET 3 AF2 6 PHE E 468 PRO E 470 -1 O ARG E 469 N ILE E 455 SHEET 4 AF2 6 GLY E 441 ARG E 456 -1 N ILE E 455 O ARG E 469 SHEET 5 AF2 6 ILE E 284 GLY E 312 -1 N VAL E 286 O LEU E 452 SHEET 6 AF2 6 ARG E 315 ILE E 323 -1 O PHE E 317 N ILE E 307 SHEET 1 AF3 4 VAL Q 3 GLN Q 6 0 SHEET 2 AF3 4 VAL Q 18 PHE Q 25 -1 O ARG Q 23 N VAL Q 5 SHEET 3 AF3 4 THR Q 77 VAL Q 82 -1 O LEU Q 80 N VAL Q 20 SHEET 4 AF3 4 VAL Q 67 ASP Q 72 -1 N TYR Q 68 O ASP Q 81 SHEET 1 AF4 6 GLU Q 10 VAL Q 11 0 SHEET 2 AF4 6 THR Q 107 THR Q 110 1 O THR Q 110 N GLU Q 10 SHEET 3 AF4 6 GLY Q 88 ASP Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AF4 6 LEU Q 34 GLN Q 39 -1 N HIS Q 35 O ALA Q 93 SHEET 5 AF4 6 GLU Q 46 ILE Q 51 -1 O GLY Q 49 N TRP Q 36 SHEET 6 AF4 6 THR Q 57 THR Q 59 -1 O THR Q 58 N TRP Q 50 SHEET 1 AF5 4 GLU Q 10 VAL Q 11 0 SHEET 2 AF5 4 THR Q 107 THR Q 110 1 O THR Q 110 N GLU Q 10 SHEET 3 AF5 4 GLY Q 88 ASP Q 95 -1 N TYR Q 90 O THR Q 107 SHEET 4 AF5 4 MET Q 100E TRP Q 103 -1 O VAL Q 102 N ARG Q 94 SHEET 1 AF6 4 LEU V 4 GLN V 6 0 SHEET 2 AF6 4 VAL V 19 ALA V 25 -1 O ARG V 24 N THR V 5 SHEET 3 AF6 4 HIS V 70 VAL V 75 -1 O PHE V 71 N CYS V 23 SHEET 4 AF6 4 PHE V 62 SER V 67 -1 N SER V 63 O THR V 74 SHEET 1 AF7 6 PHE V 10 ALA V 13 0 SHEET 2 AF7 6 THR V 102 ILE V 106 1 O GLU V 105 N ALA V 13 SHEET 3 AF7 6 THR V 85 HIS V 90 -1 N TYR V 86 O THR V 102 SHEET 4 AF7 6 LEU V 33 GLN V 38 -1 N TYR V 36 O PHE V 87 SHEET 5 AF7 6 ASN V 45 TYR V 49 -1 O LEU V 47 N TRP V 35 SHEET 6 AF7 6 THR V 53 LEU V 54 -1 O THR V 53 N TYR V 49 SHEET 1 AF8 3 LEU F 494 THR F 499 0 SHEET 2 AF8 3 TRP F 35 TYR F 40 -1 N TYR F 39 O GLY F 495 SHEET 3 AF8 3 ILE M 603 PRO M 609 -1 O CYS M 604 N VAL F 38 SHEET 1 AF9 5 TRP F 45 GLU F 47 0 SHEET 2 AF9 5 TYR F 486 ILE F 491 -1 O LYS F 490 N LYS F 46 SHEET 3 AF9 5 PHE F 223 CYS F 228 -1 N LEU F 226 O LYS F 487 SHEET 4 AF9 5 VAL F 242 VAL F 245 -1 O VAL F 245 N ILE F 225 SHEET 5 AF9 5 GLU F 83 VAL F 85 -1 N VAL F 84 O THR F 244 SHEET 1 AG1 4 VAL F 75 PRO F 76 0 SHEET 2 AG1 4 PHE F 53 SER F 56 1 N SER F 56 O VAL F 75 SHEET 3 AG1 4 ILE F 215 CYS F 218 -1 O CYS F 218 N PHE F 53 SHEET 4 AG1 4 CYS F 247 ILE F 251 -1 O ILE F 251 N ILE F 215 SHEET 1 AG2 2 GLU F 91 ASN F 94 0 SHEET 2 AG2 2 THR F 236 CYS F 239 -1 O GLY F 237 N PHE F 93 SHEET 1 AG3 4 VAL F 120 LYS F 121 0 SHEET 2 AG3 4 ILE F 201 GLN F 203 -1 O GLN F 203 N VAL F 120 SHEET 3 AG3 4 ALA F 433 TYR F 435 1 O TYR F 435 N THR F 202 SHEET 4 AG3 4 ILE F 423 VAL F 424 -1 N VAL F 424 O MET F 434 SHEET 1 AG4 5 GLN F 170 TYR F 177 0 SHEET 2 AG4 5 ILE F 154 ILE F 161 -1 N LYS F 155 O PHE F 176 SHEET 3 AG4 5 LEU F 129 ASP F 133 -1 N ASN F 130 O SER F 158 SHEET 4 AG4 5 SER F 190 LEU F 193 -1 O TYR F 191 N LEU F 129 SHEET 5 AG4 5 VAL F 181 PRO F 183 -1 N VAL F 182 O ARG F 192 SHEET 1 AG5 6 VAL F 271 SER F 274 0 SHEET 2 AG5 6 ILE F 284 GLY F 312 -1 O GLN F 287 N VAL F 271 SHEET 3 AG5 6 ALA F 329 ILE F 333 -1 O ASN F 332 N ASN F 295 SHEET 4 AG5 6 VAL F 415 ILE F 420 -1 O CYS F 418 N ALA F 329 SHEET 5 AG5 6 GLU F 381 CYS F 385 -1 N TYR F 384 O ARG F 419 SHEET 6 AG5 6 HIS F 374 CYS F 378 -1 N HIS F 374 O CYS F 385 SHEET 1 AG6 6 LEU F 260 LEU F 261 0 SHEET 2 AG6 6 GLY F 441 ARG F 456 -1 O THR F 450 N LEU F 260 SHEET 3 AG6 6 PHE F 468 PRO F 470 -1 O ARG F 469 N ILE F 455 SHEET 4 AG6 6 GLY F 441 ARG F 456 -1 N ILE F 455 O ARG F 469 SHEET 5 AG6 6 ILE F 284 GLY F 312 -1 N VAL F 286 O LEU F 452 SHEET 6 AG6 6 ARG F 315 ILE F 323 -1 O PHE F 317 N ILE F 307 SHEET 1 AG7 4 VAL R 3 GLN R 6 0 SHEET 2 AG7 4 VAL R 18 PHE R 25 -1 O ARG R 23 N VAL R 5 SHEET 3 AG7 4 THR R 77 VAL R 82 -1 O LEU R 80 N VAL R 20 SHEET 4 AG7 4 VAL R 67 ASP R 72 -1 N TYR R 68 O ASP R 81 SHEET 1 AG8 6 GLU R 10 VAL R 11 0 SHEET 2 AG8 6 THR R 107 THR R 110 1 O THR R 110 N GLU R 10 SHEET 3 AG8 6 GLY R 88 ASP R 95 -1 N TYR R 90 O THR R 107 SHEET 4 AG8 6 LEU R 34 GLN R 39 -1 N HIS R 35 O ALA R 93 SHEET 5 AG8 6 GLU R 46 ILE R 51 -1 O GLY R 49 N TRP R 36 SHEET 6 AG8 6 THR R 57 THR R 59 -1 O THR R 58 N TRP R 50 SHEET 1 AG9 4 GLU R 10 VAL R 11 0 SHEET 2 AG9 4 THR R 107 THR R 110 1 O THR R 110 N GLU R 10 SHEET 3 AG9 4 GLY R 88 ASP R 95 -1 N TYR R 90 O THR R 107 SHEET 4 AG9 4 MET R 100E TRP R 103 -1 O VAL R 102 N ARG R 94 SHEET 1 AH1 4 LEU W 4 GLN W 6 0 SHEET 2 AH1 4 VAL W 19 ALA W 25 -1 O ARG W 24 N THR W 5 SHEET 3 AH1 4 HIS W 70 VAL W 75 -1 O PHE W 71 N CYS W 23 SHEET 4 AH1 4 PHE W 62 SER W 67 -1 N SER W 63 O THR W 74 SHEET 1 AH2 6 PHE W 10 ALA W 13 0 SHEET 2 AH2 6 THR W 102 ILE W 106 1 O GLU W 105 N ALA W 13 SHEET 3 AH2 6 THR W 85 HIS W 90 -1 N TYR W 86 O THR W 102 SHEET 4 AH2 6 LEU W 33 GLN W 38 -1 N TYR W 36 O PHE W 87 SHEET 5 AH2 6 ASN W 45 TYR W 49 -1 O LEU W 47 N TRP W 35 SHEET 6 AH2 6 THR W 53 LEU W 54 -1 O THR W 53 N TYR W 49 SHEET 1 AH3 3 LEU G 494 THR G 499 0 SHEET 2 AH3 3 TRP G 35 TYR G 40 -1 N TYR G 39 O GLY G 495 SHEET 3 AH3 3 ILE N 603 PRO N 609 -1 O CYS N 604 N VAL G 38 SHEET 1 AH4 5 TRP G 45 GLU G 47 0 SHEET 2 AH4 5 TYR G 486 ILE G 491 -1 O LYS G 490 N LYS G 46 SHEET 3 AH4 5 PHE G 223 CYS G 228 -1 N LEU G 226 O LYS G 487 SHEET 4 AH4 5 VAL G 242 VAL G 245 -1 O VAL G 245 N ILE G 225 SHEET 5 AH4 5 GLU G 83 VAL G 85 -1 N VAL G 84 O THR G 244 SHEET 1 AH5 4 VAL G 75 PRO G 76 0 SHEET 2 AH5 4 PHE G 53 SER G 56 1 N SER G 56 O VAL G 75 SHEET 3 AH5 4 ILE G 215 CYS G 218 -1 O CYS G 218 N PHE G 53 SHEET 4 AH5 4 CYS G 247 ILE G 251 -1 O ILE G 251 N ILE G 215 SHEET 1 AH6 2 GLU G 91 ASN G 94 0 SHEET 2 AH6 2 THR G 236 CYS G 239 -1 O GLY G 237 N PHE G 93 SHEET 1 AH7 4 VAL G 120 LYS G 121 0 SHEET 2 AH7 4 ILE G 201 GLN G 203 -1 O GLN G 203 N VAL G 120 SHEET 3 AH7 4 ALA G 433 TYR G 435 1 O TYR G 435 N THR G 202 SHEET 4 AH7 4 ILE G 423 VAL G 424 -1 N VAL G 424 O MET G 434 SHEET 1 AH8 5 GLN G 170 TYR G 177 0 SHEET 2 AH8 5 ILE G 154 ILE G 161 -1 N LYS G 155 O PHE G 176 SHEET 3 AH8 5 LEU G 129 ASP G 133 -1 N ASN G 130 O SER G 158 SHEET 4 AH8 5 SER G 190 LEU G 193 -1 O TYR G 191 N LEU G 129 SHEET 5 AH8 5 VAL G 181 PRO G 183 -1 N VAL G 182 O ARG G 192 SHEET 1 AH9 6 VAL G 271 SER G 274 0 SHEET 2 AH9 6 ILE G 284 GLY G 312 -1 O GLN G 287 N VAL G 271 SHEET 3 AH9 6 ALA G 329 ILE G 333 -1 O ASN G 332 N ASN G 295 SHEET 4 AH9 6 VAL G 415 ILE G 420 -1 O CYS G 418 N ALA G 329 SHEET 5 AH9 6 GLU G 381 CYS G 385 -1 N TYR G 384 O ARG G 419 SHEET 6 AH9 6 HIS G 374 CYS G 378 -1 N HIS G 374 O CYS G 385 SHEET 1 AI1 6 LEU G 260 LEU G 261 0 SHEET 2 AI1 6 GLY G 441 ARG G 456 -1 O THR G 450 N LEU G 260 SHEET 3 AI1 6 PHE G 468 PRO G 470 -1 O ARG G 469 N ILE G 455 SHEET 4 AI1 6 GLY G 441 ARG G 456 -1 N ILE G 455 O ARG G 469 SHEET 5 AI1 6 ILE G 284 GLY G 312 -1 N VAL G 286 O LEU G 452 SHEET 6 AI1 6 ARG G 315 ILE G 323 -1 O PHE G 317 N ILE G 307 SHEET 1 AI2 4 VAL S 3 GLN S 6 0 SHEET 2 AI2 4 VAL S 18 PHE S 25 -1 O ARG S 23 N VAL S 5 SHEET 3 AI2 4 THR S 77 VAL S 82 -1 O LEU S 80 N VAL S 20 SHEET 4 AI2 4 VAL S 67 ASP S 72 -1 N TYR S 68 O ASP S 81 SHEET 1 AI3 6 GLU S 10 VAL S 11 0 SHEET 2 AI3 6 THR S 107 THR S 110 1 O THR S 110 N GLU S 10 SHEET 3 AI3 6 GLY S 88 ASP S 95 -1 N TYR S 90 O THR S 107 SHEET 4 AI3 6 LEU S 34 GLN S 39 -1 N HIS S 35 O ALA S 93 SHEET 5 AI3 6 GLU S 46 ILE S 51 -1 O GLY S 49 N TRP S 36 SHEET 6 AI3 6 THR S 57 THR S 59 -1 O THR S 58 N TRP S 50 SHEET 1 AI4 4 GLU S 10 VAL S 11 0 SHEET 2 AI4 4 THR S 107 THR S 110 1 O THR S 110 N GLU S 10 SHEET 3 AI4 4 GLY S 88 ASP S 95 -1 N TYR S 90 O THR S 107 SHEET 4 AI4 4 MET S 100E TRP S 103 -1 O VAL S 102 N ARG S 94 SHEET 1 AI5 4 LEU X 4 GLN X 6 0 SHEET 2 AI5 4 VAL X 19 ALA X 25 -1 O ARG X 24 N THR X 5 SHEET 3 AI5 4 HIS X 70 VAL X 75 -1 O PHE X 71 N CYS X 23 SHEET 4 AI5 4 PHE X 62 SER X 67 -1 N SER X 63 O THR X 74 SHEET 1 AI6 6 PHE X 10 ALA X 13 0 SHEET 2 AI6 6 THR X 102 ILE X 106 1 O GLU X 105 N ALA X 13 SHEET 3 AI6 6 THR X 85 HIS X 90 -1 N TYR X 86 O THR X 102 SHEET 4 AI6 6 LEU X 33 GLN X 38 -1 N TYR X 36 O PHE X 87 SHEET 5 AI6 6 ASN X 45 TYR X 49 -1 O LEU X 47 N TRP X 35 SHEET 6 AI6 6 THR X 53 LEU X 54 -1 O THR X 53 N TYR X 49 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.06 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.21 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.02 SSBOND 5 CYS A 218 CYS A 247 1555 1555 2.03 SSBOND 6 CYS A 228 CYS A 239 1555 1555 2.04 SSBOND 7 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 8 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 9 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 10 CYS B 598 CYS B 604 1555 1555 2.03 SSBOND 11 CYS H 22 CYS H 92 1555 1555 2.06 SSBOND 12 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 13 CYS C 54 CYS C 74 1555 1555 2.06 SSBOND 14 CYS C 119 CYS C 205 1555 1555 2.21 SSBOND 15 CYS C 126 CYS C 196 1555 1555 2.03 SSBOND 16 CYS C 131 CYS C 157 1555 1555 2.02 SSBOND 17 CYS C 218 CYS C 247 1555 1555 2.03 SSBOND 18 CYS C 228 CYS C 239 1555 1555 2.04 SSBOND 19 CYS C 296 CYS C 331 1555 1555 2.03 SSBOND 20 CYS C 378 CYS C 445 1555 1555 2.03 SSBOND 21 CYS C 385 CYS C 418 1555 1555 2.03 SSBOND 22 CYS I 598 CYS I 604 1555 1555 2.03 SSBOND 23 CYS O 22 CYS O 92 1555 1555 2.06 SSBOND 24 CYS T 23 CYS T 88 1555 1555 2.03 SSBOND 25 CYS D 54 CYS D 74 1555 1555 2.06 SSBOND 26 CYS D 119 CYS D 205 1555 1555 2.21 SSBOND 27 CYS D 126 CYS D 196 1555 1555 2.03 SSBOND 28 CYS D 131 CYS D 157 1555 1555 2.02 SSBOND 29 CYS D 218 CYS D 247 1555 1555 2.03 SSBOND 30 CYS D 228 CYS D 239 1555 1555 2.04 SSBOND 31 CYS D 296 CYS D 331 1555 1555 2.03 SSBOND 32 CYS D 378 CYS D 445 1555 1555 2.03 SSBOND 33 CYS D 385 CYS D 418 1555 1555 2.03 SSBOND 34 CYS J 598 CYS J 604 1555 1555 2.03 SSBOND 35 CYS P 22 CYS P 92 1555 1555 2.06 SSBOND 36 CYS U 23 CYS U 88 1555 1555 2.03 SSBOND 37 CYS E 54 CYS E 74 1555 1555 2.06 SSBOND 38 CYS E 119 CYS E 205 1555 1555 2.21 SSBOND 39 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 40 CYS E 131 CYS E 157 1555 1555 2.02 SSBOND 41 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 42 CYS E 228 CYS E 239 1555 1555 2.04 SSBOND 43 CYS E 296 CYS E 331 1555 1555 2.03 SSBOND 44 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 45 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 46 CYS K 598 CYS K 604 1555 1555 2.03 SSBOND 47 CYS Q 22 CYS Q 92 1555 1555 2.06 SSBOND 48 CYS V 23 CYS V 88 1555 1555 2.03 SSBOND 49 CYS F 54 CYS F 74 1555 1555 2.06 SSBOND 50 CYS F 119 CYS F 205 1555 1555 2.21 SSBOND 51 CYS F 126 CYS F 196 1555 1555 2.03 SSBOND 52 CYS F 131 CYS F 157 1555 1555 2.02 SSBOND 53 CYS F 218 CYS F 247 1555 1555 2.03 SSBOND 54 CYS F 228 CYS F 239 1555 1555 2.04 SSBOND 55 CYS F 296 CYS F 331 1555 1555 2.03 SSBOND 56 CYS F 378 CYS F 445 1555 1555 2.03 SSBOND 57 CYS F 385 CYS F 418 1555 1555 2.03 SSBOND 58 CYS M 598 CYS M 604 1555 1555 2.03 SSBOND 59 CYS R 22 CYS R 92 1555 1555 2.06 SSBOND 60 CYS W 23 CYS W 88 1555 1555 2.03 SSBOND 61 CYS G 54 CYS G 74 1555 1555 2.06 SSBOND 62 CYS G 119 CYS G 205 1555 1555 2.21 SSBOND 63 CYS G 126 CYS G 196 1555 1555 2.03 SSBOND 64 CYS G 131 CYS G 157 1555 1555 2.02 SSBOND 65 CYS G 218 CYS G 247 1555 1555 2.03 SSBOND 66 CYS G 228 CYS G 239 1555 1555 2.04 SSBOND 67 CYS G 296 CYS G 331 1555 1555 2.03 SSBOND 68 CYS G 378 CYS G 445 1555 1555 2.03 SSBOND 69 CYS G 385 CYS G 418 1555 1555 2.03 SSBOND 70 CYS N 598 CYS N 604 1555 1555 2.03 SSBOND 71 CYS S 22 CYS S 92 1555 1555 2.06 SSBOND 72 CYS X 23 CYS X 88 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG Y 1 1555 1555 1.47 LINK ND2 ASN A 130 C1 NAG A 627 1555 1555 1.48 LINK ND2 ASN A 197 C1 NAG Z 1 1555 1555 1.47 LINK ND2 ASN A 234 C1 NAG A 608 1555 1555 1.46 LINK ND2 ASN A 241 C1 NAG a 1 1555 1555 1.48 LINK ND2 ASN A 262 C1 NAG b 1 1555 1555 1.48 LINK ND2 ASN A 276 C1 NAG c 1 1555 1555 1.46 LINK ND2 ASN A 295 C1 NAG A 620 1555 1555 1.47 LINK ND2 ASN A 332 C1 NAG d 1 1555 1555 1.47 LINK ND2 ASN A 448 C1 NAG e 1 1555 1555 1.47 LINK ND2 ASN C 88 C1 NAG f 1 1555 1555 1.47 LINK ND2 ASN C 130 C1 NAG C 627 1555 1555 1.47 LINK ND2 ASN C 197 C1 NAG g 1 1555 1555 1.47 LINK ND2 ASN C 234 C1 NAG C 608 1555 1555 1.46 LINK ND2 ASN C 241 C1 NAG h 1 1555 1555 1.48 LINK ND2 ASN C 262 C1 NAG i 1 1555 1555 1.48 LINK ND2 ASN C 276 C1 NAG j 1 1555 1555 1.46 LINK ND2 ASN C 295 C1 NAG C 620 1555 1555 1.47 LINK ND2 ASN C 332 C1 NAG k 1 1555 1555 1.47 LINK ND2 ASN C 448 C1 NAG l 1 1555 1555 1.47 LINK ND2 ASN D 88 C1 NAG m 1 1555 1555 1.47 LINK ND2 ASN D 130 C1 NAG D 627 1555 1555 1.47 LINK ND2 ASN D 197 C1 NAG n 1 1555 1555 1.47 LINK ND2 ASN D 234 C1 NAG D 608 1555 1555 1.46 LINK ND2 ASN D 241 C1 NAG o 1 1555 1555 1.48 LINK ND2 ASN D 262 C1 NAG p 1 1555 1555 1.48 LINK ND2 ASN D 276 C1 NAG q 1 1555 1555 1.46 LINK ND2 ASN D 295 C1 NAG D 620 1555 1555 1.47 LINK ND2 ASN D 332 C1 NAG r 1 1555 1555 1.47 LINK ND2 ASN D 448 C1 NAG s 1 1555 1555 1.47 LINK ND2 ASN E 88 C1 NAG t 1 1555 1555 1.47 LINK ND2 ASN E 130 C1 NAG E 627 1555 1555 1.48 LINK ND2 ASN E 197 C1 NAG u 1 1555 1555 1.47 LINK ND2 ASN E 234 C1 NAG E 608 1555 1555 1.46 LINK ND2 ASN E 241 C1 NAG v 1 1555 1555 1.48 LINK ND2 ASN E 262 C1 NAG w 1 1555 1555 1.48 LINK ND2 ASN E 276 C1 NAG x 1 1555 1555 1.46 LINK ND2 ASN E 295 C1 NAG E 620 1555 1555 1.47 LINK ND2 ASN E 332 C1 NAG y 1 1555 1555 1.47 LINK ND2 ASN E 448 C1 NAG z 1 1555 1555 1.47 LINK ND2 ASN F 88 C1 NAG 0 1 1555 1555 1.47 LINK ND2 ASN F 130 C1 NAG F 627 1555 1555 1.47 LINK ND2 ASN F 197 C1 NAG 1 1 1555 1555 1.47 LINK ND2 ASN F 234 C1 NAG F 608 1555 1555 1.46 LINK ND2 ASN F 241 C1 NAG 2 1 1555 1555 1.48 LINK ND2 ASN F 262 C1 NAG 3 1 1555 1555 1.48 LINK ND2 ASN F 276 C1 NAG 4 1 1555 1555 1.46 LINK ND2 ASN F 295 C1 NAG F 620 1555 1555 1.47 LINK ND2 ASN F 332 C1 NAG 5 1 1555 1555 1.47 LINK ND2 ASN F 448 C1 NAG 6 1 1555 1555 1.47 LINK ND2 ASN G 88 C1 NAG 7 1 1555 1555 1.47 LINK ND2 ASN G 130 C1 NAG G 627 1555 1555 1.47 LINK ND2 ASN G 197 C1 NAG 8 1 1555 1555 1.47 LINK ND2 ASN G 234 C1 NAG G 608 1555 1555 1.46 LINK ND2 ASN G 241 C1 NAG 9 1 1555 1555 1.48 LINK ND2 ASN G 262 C1 NAGAA 1 1555 1555 1.48 LINK ND2 ASN G 276 C1 NAGBA 1 1555 1555 1.46 LINK ND2 ASN G 295 C1 NAG G 620 1555 1555 1.47 LINK ND2 ASN G 332 C1 NAGCA 1 1555 1555 1.47 LINK ND2 ASN G 448 C1 NAGDA 1 1555 1555 1.47 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.48 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.47 LINK O3 BMA Y 3 C1 MAN Y 4 1555 1555 1.44 LINK O6 BMA Y 3 C1 MAN Y 5 1555 1555 1.11 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.48 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.48 LINK O4 NAG a 2 C1 BMA a 3 1555 1555 1.47 LINK O6 BMA a 3 C1 MAN a 4 1555 1555 1.47 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.48 LINK O4 NAG b 2 C1 BMA b 3 1555 1555 1.48 LINK O3 BMA b 3 C1 MAN b 4 1555 1555 1.48 LINK O6 BMA b 3 C1 MAN b 5 1555 1555 1.47 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.50 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.48 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.48 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.47 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.48 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.48 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.47 LINK O3 BMA f 3 C1 MAN f 4 1555 1555 1.44 LINK O6 BMA f 3 C1 MAN f 5 1555 1555 1.11 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.48 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.48 LINK O4 NAG h 2 C1 BMA h 3 1555 1555 1.47 LINK O6 BMA h 3 C1 MAN h 4 1555 1555 1.47 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.48 LINK O4 NAG i 2 C1 BMA i 3 1555 1555 1.48 LINK O3 BMA i 3 C1 MAN i 4 1555 1555 1.48 LINK O6 BMA i 3 C1 MAN i 5 1555 1555 1.47 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.50 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.48 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.48 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.47 LINK O4 NAG l 2 C1 BMA l 3 1555 1555 1.48 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.48 LINK O4 NAG m 2 C1 BMA m 3 1555 1555 1.47 LINK O3 BMA m 3 C1 MAN m 4 1555 1555 1.44 LINK O6 BMA m 3 C1 MAN m 5 1555 1555 1.11 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.48 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.48 LINK O4 NAG o 2 C1 BMA o 3 1555 1555 1.47 LINK O6 BMA o 3 C1 MAN o 4 1555 1555 1.47 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.47 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.48 LINK O3 BMA p 3 C1 MAN p 4 1555 1555 1.48 LINK O6 BMA p 3 C1 MAN p 5 1555 1555 1.47 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.50 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.48 LINK O4 NAG r 2 C1 BMA r 3 1555 1555 1.48 LINK O4 NAG s 1 C1 NAG s 2 1555 1555 1.47 LINK O4 NAG s 2 C1 BMA s 3 1555 1555 1.48 LINK O4 NAG t 1 C1 NAG t 2 1555 1555 1.48 LINK O4 NAG t 2 C1 BMA t 3 1555 1555 1.47 LINK O3 BMA t 3 C1 MAN t 4 1555 1555 1.44 LINK O6 BMA t 3 C1 MAN t 5 1555 1555 1.11 LINK O4 NAG u 1 C1 NAG u 2 1555 1555 1.48 LINK O4 NAG v 1 C1 NAG v 2 1555 1555 1.48 LINK O4 NAG v 2 C1 BMA v 3 1555 1555 1.47 LINK O6 BMA v 3 C1 MAN v 4 1555 1555 1.47 LINK O4 NAG w 1 C1 NAG w 2 1555 1555 1.48 LINK O4 NAG w 2 C1 BMA w 3 1555 1555 1.48 LINK O3 BMA w 3 C1 MAN w 4 1555 1555 1.48 LINK O6 BMA w 3 C1 MAN w 5 1555 1555 1.47 LINK O4 NAG x 1 C1 NAG x 2 1555 1555 1.50 LINK O4 NAG y 1 C1 NAG y 2 1555 1555 1.48 LINK O4 NAG y 2 C1 BMA y 3 1555 1555 1.48 LINK O4 NAG z 1 C1 NAG z 2 1555 1555 1.47 LINK O4 NAG z 2 C1 BMA z 3 1555 1555 1.48 LINK O4 NAG 0 1 C1 NAG 0 2 1555 1555 1.48 LINK O4 NAG 0 2 C1 BMA 0 3 1555 1555 1.47 LINK O3 BMA 0 3 C1 MAN 0 4 1555 1555 1.44 LINK O6 BMA 0 3 C1 MAN 0 5 1555 1555 1.11 LINK O4 NAG 1 1 C1 NAG 1 2 1555 1555 1.48 LINK O4 NAG 2 1 C1 NAG 2 2 1555 1555 1.48 LINK O4 NAG 2 2 C1 BMA 2 3 1555 1555 1.47 LINK O6 BMA 2 3 C1 MAN 2 4 1555 1555 1.47 LINK O4 NAG 3 1 C1 NAG 3 2 1555 1555 1.48 LINK O4 NAG 3 2 C1 BMA 3 3 1555 1555 1.48 LINK O3 BMA 3 3 C1 MAN 3 4 1555 1555 1.48 LINK O6 BMA 3 3 C1 MAN 3 5 1555 1555 1.47 LINK O4 NAG 4 1 C1 NAG 4 2 1555 1555 1.50 LINK O4 NAG 5 1 C1 NAG 5 2 1555 1555 1.48 LINK O4 NAG 5 2 C1 BMA 5 3 1555 1555 1.48 LINK O4 NAG 6 1 C1 NAG 6 2 1555 1555 1.47 LINK O4 NAG 6 2 C1 BMA 6 3 1555 1555 1.48 LINK O4 NAG 7 1 C1 NAG 7 2 1555 1555 1.48 LINK O4 NAG 7 2 C1 BMA 7 3 1555 1555 1.47 LINK O3 BMA 7 3 C1 MAN 7 4 1555 1555 1.44 LINK O6 BMA 7 3 C1 MAN 7 5 1555 1555 1.11 LINK O4 NAG 8 1 C1 NAG 8 2 1555 1555 1.48 LINK O4 NAG 9 1 C1 NAG 9 2 1555 1555 1.48 LINK O4 NAG 9 2 C1 BMA 9 3 1555 1555 1.47 LINK O6 BMA 9 3 C1 MAN 9 4 1555 1555 1.47 LINK O4 NAGAA 1 C1 NAGAA 2 1555 1555 1.47 LINK O4 NAGAA 2 C1 BMAAA 3 1555 1555 1.48 LINK O3 BMAAA 3 C1 MANAA 4 1555 1555 1.48 LINK O6 BMAAA 3 C1 MANAA 5 1555 1555 1.47 LINK O4 NAGBA 1 C1 NAGBA 2 1555 1555 1.50 LINK O4 NAGCA 1 C1 NAGCA 2 1555 1555 1.48 LINK O4 NAGCA 2 C1 BMACA 3 1555 1555 1.48 LINK O4 NAGDA 1 C1 NAGDA 2 1555 1555 1.47 LINK O4 NAGDA 2 C1 BMADA 3 1555 1555 1.48 CISPEP 1 TYR L 94 PRO L 95 0 5.93 CISPEP 2 TYR T 94 PRO T 95 0 5.98 CISPEP 3 TYR U 94 PRO U 95 0 5.99 CISPEP 4 TYR V 94 PRO V 95 0 5.93 CISPEP 5 TYR W 94 PRO W 95 0 5.98 CISPEP 6 TYR X 94 PRO X 95 0 5.99 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000