HEADER IMMUNE SYSTEM 18-DEC-18 6NF2 TITLE CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY 0PV-C.01 IN COMPLEX TITLE 2 WITH HIV-1 ENV BG505 DS-SOSIP AND ANTIBODIES VRC03 AND PGT122 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; COMPND 3 CHAIN: A, G, Q; COMPND 4 ENGINEERED: YES; COMPND 5 MUTATION: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; COMPND 8 CHAIN: B, I, R; COMPND 9 ENGINEERED: YES; COMPND 10 MUTATION: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: VRC03 HEAVY CHAIN; COMPND 13 CHAIN: C, N, V; COMPND 14 ENGINEERED: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: VRC03 LIGHT CHAIN; COMPND 17 CHAIN: D, M, U; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: PGT122 HEAVY CHAIN; COMPND 21 CHAIN: E, J, S; COMPND 22 ENGINEERED: YES; COMPND 23 MOL_ID: 6; COMPND 24 MOLECULE: PGT122 LIGHT CHAIN; COMPND 25 CHAIN: F, K, T; COMPND 26 ENGINEERED: YES; COMPND 27 MOL_ID: 7; COMPND 28 MOLECULE: 0PV-C.01 HEAVY CHAIN; COMPND 29 CHAIN: H, O, W; COMPND 30 ENGINEERED: YES; COMPND 31 MOL_ID: 8; COMPND 32 MOLECULE: 0PV-C.01 LIGHT CHAIN; COMPND 33 CHAIN: L, P, X; COMPND 34 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 STRAIN: BG505; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 11 ORGANISM_TAXID: 11676; SOURCE 12 STRAIN: BG505; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 17 MOL_ID: 3; SOURCE 18 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 19 ORGANISM_COMMON: HUMAN; SOURCE 20 ORGANISM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 22 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 23 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 24 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 25 MOL_ID: 4; SOURCE 26 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 27 ORGANISM_COMMON: HUMAN; SOURCE 28 ORGANISM_TAXID: 9606; SOURCE 29 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 30 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 31 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 32 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 33 MOL_ID: 5; SOURCE 34 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 35 ORGANISM_COMMON: HUMAN; SOURCE 36 ORGANISM_TAXID: 9606; SOURCE 37 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 38 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 39 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 40 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 41 MOL_ID: 6; SOURCE 42 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 43 ORGANISM_COMMON: HUMAN; SOURCE 44 ORGANISM_TAXID: 9606; SOURCE 45 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 46 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 47 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 48 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 49 MOL_ID: 7; SOURCE 50 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 51 ORGANISM_COMMON: HUMAN; SOURCE 52 ORGANISM_TAXID: 9606; SOURCE 53 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 54 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 55 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 56 EXPRESSION_SYSTEM_STRAIN: HEK293; SOURCE 57 MOL_ID: 8; SOURCE 58 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 59 ORGANISM_COMMON: HUMAN; SOURCE 60 ORGANISM_TAXID: 9606; SOURCE 61 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 62 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 63 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 64 EXPRESSION_SYSTEM_STRAIN: HEK293 KEYWDS FUSION PEPTIDE, FP, HIV-1, SOSIP, VACCINE, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR J.GORMAN,P.D.KWONG REVDAT 1 24-JUL-19 6NF2 0 JRNL AUTH J.GORMAN,P.D.KWONG JRNL TITL ANTIBODY LINEAGES WITH VACCINE-INDUCED ANTIGEN- BINDING JRNL TITL 2 HOTSPOTS DEVELOP BROAD HIV NEUTRALIZATION JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.70 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : DOG PICKER, LEGINON, CTFFIND, REMARK 3 CRYOSPARC, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6CDI REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.700 REMARK 3 NUMBER OF PARTICLES : 98419 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 6NF2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-DEC-18. REMARK 100 THE DEPOSITION ID IS D_1000238410. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HIV-1 ENV BG505 DS-SOSIP AND REMARK 245 ANTIBODIES 0PV-C.01, VRC03 AND REMARK 245 PGT122; ENVELOPE GLYCOPROTEIN REMARK 245 GP120; ENVELOPE GLYCOPROTEIN REMARK 245 GP41; VRC03; PGT122; 0PV-C.01 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 1767 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : NULL REMARK 245 MAXIMUM DEFOCUS (NM) : NULL REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 73.46 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLU A 185A REMARK 465 ASN A 185B REMARK 465 GLN A 185C REMARK 465 GLY A 185D REMARK 465 ASN A 185E REMARK 465 ARG A 185F REMARK 465 SER A 185G REMARK 465 ASN A 185H REMARK 465 ASN A 185I REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 ALA B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 LYS B 567 REMARK 465 LEU B 568 REMARK 465 SER C 112 REMARK 465 SER C 113 REMARK 465 ALA C 114 REMARK 465 SER C 115 REMARK 465 THR C 116 REMARK 465 LYS C 117 REMARK 465 GLY C 118 REMARK 465 PRO C 119 REMARK 465 SER C 120 REMARK 465 VAL C 121 REMARK 465 PHE C 122 REMARK 465 PRO C 123 REMARK 465 LEU C 124 REMARK 465 ALA C 125 REMARK 465 PRO C 126 REMARK 465 SER C 127 REMARK 465 SER C 128 REMARK 465 LYS C 129 REMARK 465 SER C 130 REMARK 465 THR C 131 REMARK 465 SER C 132 REMARK 465 SER C 133 REMARK 465 GLY C 134 REMARK 465 GLY C 135 REMARK 465 THR C 136 REMARK 465 ALA C 137 REMARK 465 ALA C 138 REMARK 465 LEU C 139 REMARK 465 GLY C 140 REMARK 465 CYS C 141 REMARK 465 LEU C 142 REMARK 465 VAL C 143 REMARK 465 LYS C 144 REMARK 465 ASP C 145 REMARK 465 TYR C 146 REMARK 465 PHE C 147 REMARK 465 PRO C 148 REMARK 465 GLU C 149 REMARK 465 PRO C 150 REMARK 465 VAL C 151 REMARK 465 THR C 152 REMARK 465 VAL C 153 REMARK 465 SER C 154 REMARK 465 TRP C 155 REMARK 465 ASN C 156 REMARK 465 SER C 157 REMARK 465 GLY C 158 REMARK 465 ALA C 159 REMARK 465 LEU C 160 REMARK 465 THR C 161 REMARK 465 SER C 162 REMARK 465 GLY C 163 REMARK 465 VAL C 164 REMARK 465 HIS C 165 REMARK 465 THR C 166 REMARK 465 PHE C 167 REMARK 465 PRO C 168 REMARK 465 ALA C 169 REMARK 465 VAL C 170 REMARK 465 LEU C 171 REMARK 465 GLN C 172 REMARK 465 SER C 173 REMARK 465 SER C 174 REMARK 465 GLY C 175 REMARK 465 LEU C 176 REMARK 465 TYR C 177 REMARK 465 SER C 178 REMARK 465 LEU C 179 REMARK 465 SER C 180 REMARK 465 SER C 181 REMARK 465 VAL C 182 REMARK 465 VAL C 183 REMARK 465 THR C 184 REMARK 465 VAL C 185 REMARK 465 PRO C 186 REMARK 465 SER C 187 REMARK 465 SER C 188 REMARK 465 SER C 189 REMARK 465 LEU C 190 REMARK 465 GLY C 191 REMARK 465 THR C 192 REMARK 465 GLN C 193 REMARK 465 THR C 194 REMARK 465 TYR C 195 REMARK 465 ILE C 196 REMARK 465 CYS C 197 REMARK 465 ASN C 198 REMARK 465 VAL C 199 REMARK 465 ASN C 200 REMARK 465 HIS C 201 REMARK 465 LYS C 202 REMARK 465 PRO C 203 REMARK 465 SER C 204 REMARK 465 ASN C 205 REMARK 465 THR C 206 REMARK 465 LYS C 207 REMARK 465 VAL C 208 REMARK 465 ASP C 209 REMARK 465 LYS C 210 REMARK 465 LYS C 211 REMARK 465 VAL C 212 REMARK 465 GLU C 213 REMARK 465 PRO C 214 REMARK 465 LYS C 215 REMARK 465 SER C 216 REMARK 465 CYS C 217 REMARK 465 ASP C 218 REMARK 465 ARG D 103 REMARK 465 THR D 104 REMARK 465 VAL D 105 REMARK 465 ALA D 106 REMARK 465 ALA D 107 REMARK 465 PRO D 108 REMARK 465 SER D 109 REMARK 465 VAL D 110 REMARK 465 PHE D 111 REMARK 465 ILE D 112 REMARK 465 PHE D 113 REMARK 465 PRO D 114 REMARK 465 PRO D 115 REMARK 465 SER D 116 REMARK 465 ASP D 117 REMARK 465 GLU D 118 REMARK 465 GLN D 119 REMARK 465 LEU D 120 REMARK 465 LYS D 121 REMARK 465 SER D 122 REMARK 465 GLY D 123 REMARK 465 THR D 124 REMARK 465 ALA D 125 REMARK 465 SER D 126 REMARK 465 VAL D 127 REMARK 465 VAL D 128 REMARK 465 CYS D 129 REMARK 465 LEU D 130 REMARK 465 LEU D 131 REMARK 465 ASN D 132 REMARK 465 ASN D 133 REMARK 465 PHE D 134 REMARK 465 TYR D 135 REMARK 465 PRO D 136 REMARK 465 ARG D 137 REMARK 465 GLU D 138 REMARK 465 ALA D 139 REMARK 465 LYS D 140 REMARK 465 VAL D 141 REMARK 465 GLN D 142 REMARK 465 TRP D 143 REMARK 465 LYS D 144 REMARK 465 VAL D 145 REMARK 465 ASP D 146 REMARK 465 ASN D 147 REMARK 465 ALA D 148 REMARK 465 LEU D 149 REMARK 465 GLN D 150 REMARK 465 SER D 151 REMARK 465 GLY D 152 REMARK 465 ASN D 153 REMARK 465 SER D 154 REMARK 465 GLN D 155 REMARK 465 GLU D 156 REMARK 465 SER D 157 REMARK 465 VAL D 158 REMARK 465 THR D 159 REMARK 465 GLU D 160 REMARK 465 GLN D 161 REMARK 465 ASP D 162 REMARK 465 SER D 163 REMARK 465 LYS D 164 REMARK 465 ASP D 165 REMARK 465 SER D 166 REMARK 465 THR D 167 REMARK 465 TYR D 168 REMARK 465 SER D 169 REMARK 465 LEU D 170 REMARK 465 SER D 171 REMARK 465 SER D 172 REMARK 465 THR D 173 REMARK 465 LEU D 174 REMARK 465 THR D 175 REMARK 465 LEU D 176 REMARK 465 SER D 177 REMARK 465 LYS D 178 REMARK 465 ALA D 179 REMARK 465 ASP D 180 REMARK 465 TYR D 181 REMARK 465 GLU D 182 REMARK 465 LYS D 183 REMARK 465 HIS D 184 REMARK 465 LYS D 185 REMARK 465 VAL D 186 REMARK 465 TYR D 187 REMARK 465 ALA D 188 REMARK 465 CYS D 189 REMARK 465 GLU D 190 REMARK 465 VAL D 191 REMARK 465 THR D 192 REMARK 465 HIS D 193 REMARK 465 GLN D 194 REMARK 465 GLY D 195 REMARK 465 LEU D 196 REMARK 465 SER D 197 REMARK 465 SER D 198 REMARK 465 PRO D 199 REMARK 465 VAL D 200 REMARK 465 THR D 201 REMARK 465 LYS D 202 REMARK 465 SER D 203 REMARK 465 PHE D 204 REMARK 465 ASN D 205 REMARK 465 ARG D 206 REMARK 465 GLY D 207 REMARK 465 GLU D 208 REMARK 465 CYS D 209 REMARK 465 ALA E 112 REMARK 465 SER E 113 REMARK 465 THR E 114 REMARK 465 LYS E 115 REMARK 465 GLY E 116 REMARK 465 PRO E 117 REMARK 465 SER E 118 REMARK 465 VAL E 119 REMARK 465 PHE E 120 REMARK 465 PRO E 121 REMARK 465 LEU E 122 REMARK 465 ALA E 123 REMARK 465 PRO E 124 REMARK 465 SER E 125 REMARK 465 SER E 126 REMARK 465 LYS E 127 REMARK 465 SER E 128 REMARK 465 THR E 129 REMARK 465 SER E 130 REMARK 465 GLY E 131 REMARK 465 GLY E 132 REMARK 465 THR E 133 REMARK 465 ALA E 134 REMARK 465 ALA E 135 REMARK 465 LEU E 136 REMARK 465 GLY E 137 REMARK 465 CYS E 138 REMARK 465 LEU E 139 REMARK 465 VAL E 140 REMARK 465 LYS E 141 REMARK 465 ASP E 142 REMARK 465 TYR E 143 REMARK 465 PHE E 144 REMARK 465 PRO E 145 REMARK 465 GLU E 146 REMARK 465 PRO E 147 REMARK 465 VAL E 148 REMARK 465 THR E 149 REMARK 465 VAL E 150 REMARK 465 SER E 151 REMARK 465 TRP E 152 REMARK 465 ASN E 153 REMARK 465 SER E 154 REMARK 465 GLY E 155 REMARK 465 ALA E 156 REMARK 465 LEU E 157 REMARK 465 THR E 158 REMARK 465 SER E 159 REMARK 465 GLY E 160 REMARK 465 VAL E 161 REMARK 465 HIS E 162 REMARK 465 THR E 163 REMARK 465 PHE E 164 REMARK 465 PRO E 165 REMARK 465 ALA E 166 REMARK 465 VAL E 167 REMARK 465 LEU E 168 REMARK 465 GLN E 169 REMARK 465 SER E 170 REMARK 465 SER E 171 REMARK 465 GLY E 172 REMARK 465 LEU E 173 REMARK 465 TYR E 174 REMARK 465 SER E 175 REMARK 465 LEU E 176 REMARK 465 SER E 177 REMARK 465 SER E 178 REMARK 465 VAL E 179 REMARK 465 VAL E 180 REMARK 465 THR E 181 REMARK 465 VAL E 182 REMARK 465 PRO E 183 REMARK 465 SER E 184 REMARK 465 SER E 185 REMARK 465 SER E 186 REMARK 465 LEU E 187 REMARK 465 GLY E 188 REMARK 465 THR E 189 REMARK 465 GLN E 190 REMARK 465 THR E 191 REMARK 465 TYR E 192 REMARK 465 ILE E 193 REMARK 465 CYS E 194 REMARK 465 ASN E 195 REMARK 465 VAL E 196 REMARK 465 ASN E 197 REMARK 465 HIS E 198 REMARK 465 LYS E 199 REMARK 465 PRO E 200 REMARK 465 SER E 201 REMARK 465 ASN E 202 REMARK 465 THR E 203 REMARK 465 LYS E 204 REMARK 465 VAL E 205 REMARK 465 ASP E 206 REMARK 465 LYS E 207 REMARK 465 ARG E 208 REMARK 465 VAL E 209 REMARK 465 GLU E 210 REMARK 465 PRO E 211 REMARK 465 LYS E 212 REMARK 465 SER E 213 REMARK 465 CYS E 214 REMARK 465 ALA F 6 REMARK 465 PRO F 7 REMARK 465 SER F 108 REMARK 465 GLN F 109 REMARK 465 PRO F 110 REMARK 465 LYS F 111 REMARK 465 ALA F 112 REMARK 465 ALA F 113 REMARK 465 PRO F 114 REMARK 465 SER F 115 REMARK 465 VAL F 116 REMARK 465 THR F 117 REMARK 465 LEU F 118 REMARK 465 PHE F 119 REMARK 465 PRO F 120 REMARK 465 PRO F 121 REMARK 465 SER F 122 REMARK 465 SER F 123 REMARK 465 GLU F 124 REMARK 465 GLU F 125 REMARK 465 LEU F 126 REMARK 465 GLN F 127 REMARK 465 ALA F 128 REMARK 465 ASN F 129 REMARK 465 LYS F 130 REMARK 465 ALA F 131 REMARK 465 THR F 132 REMARK 465 LEU F 133 REMARK 465 VAL F 134 REMARK 465 CYS F 135 REMARK 465 LEU F 136 REMARK 465 ILE F 137 REMARK 465 SER F 138 REMARK 465 ASP F 139 REMARK 465 PHE F 140 REMARK 465 TYR F 141 REMARK 465 PRO F 142 REMARK 465 GLY F 143 REMARK 465 ALA F 144 REMARK 465 VAL F 145 REMARK 465 THR F 146 REMARK 465 VAL F 147 REMARK 465 ALA F 148 REMARK 465 TRP F 149 REMARK 465 LYS F 150 REMARK 465 ALA F 151 REMARK 465 ASP F 152 REMARK 465 SER F 153 REMARK 465 SER F 154 REMARK 465 PRO F 155 REMARK 465 VAL F 156 REMARK 465 LYS F 157 REMARK 465 ALA F 158 REMARK 465 GLY F 159 REMARK 465 VAL F 160 REMARK 465 GLU F 161 REMARK 465 THR F 162 REMARK 465 THR F 163 REMARK 465 THR F 164 REMARK 465 PRO F 165 REMARK 465 SER F 166 REMARK 465 LYS F 167 REMARK 465 GLN F 168 REMARK 465 SER F 169 REMARK 465 ASN F 170 REMARK 465 ASN F 171 REMARK 465 LYS F 172 REMARK 465 TYR F 173 REMARK 465 ALA F 174 REMARK 465 ALA F 175 REMARK 465 SER F 176 REMARK 465 SER F 177 REMARK 465 TYR F 178 REMARK 465 LEU F 179 REMARK 465 SER F 180 REMARK 465 LEU F 181 REMARK 465 THR F 182 REMARK 465 PRO F 183 REMARK 465 GLU F 184 REMARK 465 GLN F 185 REMARK 465 TRP F 186 REMARK 465 LYS F 187 REMARK 465 SER F 188 REMARK 465 HIS F 189 REMARK 465 LYS F 190 REMARK 465 SER F 191 REMARK 465 TYR F 192 REMARK 465 SER F 193 REMARK 465 CYS F 194 REMARK 465 GLN F 195 REMARK 465 VAL F 196 REMARK 465 THR F 197 REMARK 465 HIS F 198 REMARK 465 GLU F 199 REMARK 465 GLY F 200 REMARK 465 SER F 201 REMARK 465 THR F 202 REMARK 465 VAL F 203 REMARK 465 GLU F 204 REMARK 465 LYS F 205 REMARK 465 THR F 206 REMARK 465 VAL F 207 REMARK 465 ALA F 208 REMARK 465 PRO F 209 REMARK 465 THR F 210 REMARK 465 GLU F 211 REMARK 465 CYS F 212 REMARK 465 SER F 213 REMARK 465 GLU G 185A REMARK 465 ASN G 185B REMARK 465 GLN G 185C REMARK 465 GLY G 185D REMARK 465 ASN G 185E REMARK 465 ARG G 185F REMARK 465 SER G 185G REMARK 465 ASN G 185H REMARK 465 ASN G 185I REMARK 465 THR G 400 REMARK 465 SER G 401 REMARK 465 VAL G 402 REMARK 465 GLN G 403 REMARK 465 GLY G 404 REMARK 465 SER G 405 REMARK 465 ASN G 406 REMARK 465 SER G 407 REMARK 465 THR G 408 REMARK 465 GLY G 409 REMARK 465 SER G 410 REMARK 465 VAL G 506 REMARK 465 GLY G 507 REMARK 465 ARG G 508 REMARK 465 ARG G 509 REMARK 465 ARG G 510 REMARK 465 ARG G 511 REMARK 465 ARG G 512 REMARK 465 SER H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ILE I 548 REMARK 465 VAL I 549 REMARK 465 GLN I 550 REMARK 465 GLN I 551 REMARK 465 GLN I 552 REMARK 465 SER I 553 REMARK 465 ASN I 554 REMARK 465 LEU I 555 REMARK 465 LEU I 556 REMARK 465 ARG I 557 REMARK 465 ALA I 558 REMARK 465 PRO I 559 REMARK 465 GLU I 560 REMARK 465 ALA I 561 REMARK 465 GLN I 562 REMARK 465 GLN I 563 REMARK 465 HIS I 564 REMARK 465 LEU I 565 REMARK 465 LEU I 566 REMARK 465 LYS I 567 REMARK 465 LEU I 568 REMARK 465 ALA J 112 REMARK 465 SER J 113 REMARK 465 THR J 114 REMARK 465 LYS J 115 REMARK 465 GLY J 116 REMARK 465 PRO J 117 REMARK 465 SER J 118 REMARK 465 VAL J 119 REMARK 465 PHE J 120 REMARK 465 PRO J 121 REMARK 465 LEU J 122 REMARK 465 ALA J 123 REMARK 465 PRO J 124 REMARK 465 SER J 125 REMARK 465 SER J 126 REMARK 465 LYS J 127 REMARK 465 SER J 128 REMARK 465 THR J 129 REMARK 465 SER J 130 REMARK 465 GLY J 131 REMARK 465 GLY J 132 REMARK 465 THR J 133 REMARK 465 ALA J 134 REMARK 465 ALA J 135 REMARK 465 LEU J 136 REMARK 465 GLY J 137 REMARK 465 CYS J 138 REMARK 465 LEU J 139 REMARK 465 VAL J 140 REMARK 465 LYS J 141 REMARK 465 ASP J 142 REMARK 465 TYR J 143 REMARK 465 PHE J 144 REMARK 465 PRO J 145 REMARK 465 GLU J 146 REMARK 465 PRO J 147 REMARK 465 VAL J 148 REMARK 465 THR J 149 REMARK 465 VAL J 150 REMARK 465 SER J 151 REMARK 465 TRP J 152 REMARK 465 ASN J 153 REMARK 465 SER J 154 REMARK 465 GLY J 155 REMARK 465 ALA J 156 REMARK 465 LEU J 157 REMARK 465 THR J 158 REMARK 465 SER J 159 REMARK 465 GLY J 160 REMARK 465 VAL J 161 REMARK 465 HIS J 162 REMARK 465 THR J 163 REMARK 465 PHE J 164 REMARK 465 PRO J 165 REMARK 465 ALA J 166 REMARK 465 VAL J 167 REMARK 465 LEU J 168 REMARK 465 GLN J 169 REMARK 465 SER J 170 REMARK 465 SER J 171 REMARK 465 GLY J 172 REMARK 465 LEU J 173 REMARK 465 TYR J 174 REMARK 465 SER J 175 REMARK 465 LEU J 176 REMARK 465 SER J 177 REMARK 465 SER J 178 REMARK 465 VAL J 179 REMARK 465 VAL J 180 REMARK 465 THR J 181 REMARK 465 VAL J 182 REMARK 465 PRO J 183 REMARK 465 SER J 184 REMARK 465 SER J 185 REMARK 465 SER J 186 REMARK 465 LEU J 187 REMARK 465 GLY J 188 REMARK 465 THR J 189 REMARK 465 GLN J 190 REMARK 465 THR J 191 REMARK 465 TYR J 192 REMARK 465 ILE J 193 REMARK 465 CYS J 194 REMARK 465 ASN J 195 REMARK 465 VAL J 196 REMARK 465 ASN J 197 REMARK 465 HIS J 198 REMARK 465 LYS J 199 REMARK 465 PRO J 200 REMARK 465 SER J 201 REMARK 465 ASN J 202 REMARK 465 THR J 203 REMARK 465 LYS J 204 REMARK 465 VAL J 205 REMARK 465 ASP J 206 REMARK 465 LYS J 207 REMARK 465 ARG J 208 REMARK 465 VAL J 209 REMARK 465 GLU J 210 REMARK 465 PRO J 211 REMARK 465 LYS J 212 REMARK 465 SER J 213 REMARK 465 CYS J 214 REMARK 465 ALA K 6 REMARK 465 PRO K 7 REMARK 465 SER K 108 REMARK 465 GLN K 109 REMARK 465 PRO K 110 REMARK 465 LYS K 111 REMARK 465 ALA K 112 REMARK 465 ALA K 113 REMARK 465 PRO K 114 REMARK 465 SER K 115 REMARK 465 VAL K 116 REMARK 465 THR K 117 REMARK 465 LEU K 118 REMARK 465 PHE K 119 REMARK 465 PRO K 120 REMARK 465 PRO K 121 REMARK 465 SER K 122 REMARK 465 SER K 123 REMARK 465 GLU K 124 REMARK 465 GLU K 125 REMARK 465 LEU K 126 REMARK 465 GLN K 127 REMARK 465 ALA K 128 REMARK 465 ASN K 129 REMARK 465 LYS K 130 REMARK 465 ALA K 131 REMARK 465 THR K 132 REMARK 465 LEU K 133 REMARK 465 VAL K 134 REMARK 465 CYS K 135 REMARK 465 LEU K 136 REMARK 465 ILE K 137 REMARK 465 SER K 138 REMARK 465 ASP K 139 REMARK 465 PHE K 140 REMARK 465 TYR K 141 REMARK 465 PRO K 142 REMARK 465 GLY K 143 REMARK 465 ALA K 144 REMARK 465 VAL K 145 REMARK 465 THR K 146 REMARK 465 VAL K 147 REMARK 465 ALA K 148 REMARK 465 TRP K 149 REMARK 465 LYS K 150 REMARK 465 ALA K 151 REMARK 465 ASP K 152 REMARK 465 SER K 153 REMARK 465 SER K 154 REMARK 465 PRO K 155 REMARK 465 VAL K 156 REMARK 465 LYS K 157 REMARK 465 ALA K 158 REMARK 465 GLY K 159 REMARK 465 VAL K 160 REMARK 465 GLU K 161 REMARK 465 THR K 162 REMARK 465 THR K 163 REMARK 465 THR K 164 REMARK 465 PRO K 165 REMARK 465 SER K 166 REMARK 465 LYS K 167 REMARK 465 GLN K 168 REMARK 465 SER K 169 REMARK 465 ASN K 170 REMARK 465 ASN K 171 REMARK 465 LYS K 172 REMARK 465 TYR K 173 REMARK 465 ALA K 174 REMARK 465 ALA K 175 REMARK 465 SER K 176 REMARK 465 SER K 177 REMARK 465 TYR K 178 REMARK 465 LEU K 179 REMARK 465 SER K 180 REMARK 465 LEU K 181 REMARK 465 THR K 182 REMARK 465 PRO K 183 REMARK 465 GLU K 184 REMARK 465 GLN K 185 REMARK 465 TRP K 186 REMARK 465 LYS K 187 REMARK 465 SER K 188 REMARK 465 HIS K 189 REMARK 465 LYS K 190 REMARK 465 SER K 191 REMARK 465 TYR K 192 REMARK 465 SER K 193 REMARK 465 CYS K 194 REMARK 465 GLN K 195 REMARK 465 VAL K 196 REMARK 465 THR K 197 REMARK 465 HIS K 198 REMARK 465 GLU K 199 REMARK 465 GLY K 200 REMARK 465 SER K 201 REMARK 465 THR K 202 REMARK 465 VAL K 203 REMARK 465 GLU K 204 REMARK 465 LYS K 205 REMARK 465 THR K 206 REMARK 465 VAL K 207 REMARK 465 ALA K 208 REMARK 465 PRO K 209 REMARK 465 THR K 210 REMARK 465 GLU K 211 REMARK 465 CYS K 212 REMARK 465 SER K 213 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ARG M 103 REMARK 465 THR M 104 REMARK 465 VAL M 105 REMARK 465 ALA M 106 REMARK 465 ALA M 107 REMARK 465 PRO M 108 REMARK 465 SER M 109 REMARK 465 VAL M 110 REMARK 465 PHE M 111 REMARK 465 ILE M 112 REMARK 465 PHE M 113 REMARK 465 PRO M 114 REMARK 465 PRO M 115 REMARK 465 SER M 116 REMARK 465 ASP M 117 REMARK 465 GLU M 118 REMARK 465 GLN M 119 REMARK 465 LEU M 120 REMARK 465 LYS M 121 REMARK 465 SER M 122 REMARK 465 GLY M 123 REMARK 465 THR M 124 REMARK 465 ALA M 125 REMARK 465 SER M 126 REMARK 465 VAL M 127 REMARK 465 VAL M 128 REMARK 465 CYS M 129 REMARK 465 LEU M 130 REMARK 465 LEU M 131 REMARK 465 ASN M 132 REMARK 465 ASN M 133 REMARK 465 PHE M 134 REMARK 465 TYR M 135 REMARK 465 PRO M 136 REMARK 465 ARG M 137 REMARK 465 GLU M 138 REMARK 465 ALA M 139 REMARK 465 LYS M 140 REMARK 465 VAL M 141 REMARK 465 GLN M 142 REMARK 465 TRP M 143 REMARK 465 LYS M 144 REMARK 465 VAL M 145 REMARK 465 ASP M 146 REMARK 465 ASN M 147 REMARK 465 ALA M 148 REMARK 465 LEU M 149 REMARK 465 GLN M 150 REMARK 465 SER M 151 REMARK 465 GLY M 152 REMARK 465 ASN M 153 REMARK 465 SER M 154 REMARK 465 GLN M 155 REMARK 465 GLU M 156 REMARK 465 SER M 157 REMARK 465 VAL M 158 REMARK 465 THR M 159 REMARK 465 GLU M 160 REMARK 465 GLN M 161 REMARK 465 ASP M 162 REMARK 465 SER M 163 REMARK 465 LYS M 164 REMARK 465 ASP M 165 REMARK 465 SER M 166 REMARK 465 THR M 167 REMARK 465 TYR M 168 REMARK 465 SER M 169 REMARK 465 LEU M 170 REMARK 465 SER M 171 REMARK 465 SER M 172 REMARK 465 THR M 173 REMARK 465 LEU M 174 REMARK 465 THR M 175 REMARK 465 LEU M 176 REMARK 465 SER M 177 REMARK 465 LYS M 178 REMARK 465 ALA M 179 REMARK 465 ASP M 180 REMARK 465 TYR M 181 REMARK 465 GLU M 182 REMARK 465 LYS M 183 REMARK 465 HIS M 184 REMARK 465 LYS M 185 REMARK 465 VAL M 186 REMARK 465 TYR M 187 REMARK 465 ALA M 188 REMARK 465 CYS M 189 REMARK 465 GLU M 190 REMARK 465 VAL M 191 REMARK 465 THR M 192 REMARK 465 HIS M 193 REMARK 465 GLN M 194 REMARK 465 GLY M 195 REMARK 465 LEU M 196 REMARK 465 SER M 197 REMARK 465 SER M 198 REMARK 465 PRO M 199 REMARK 465 VAL M 200 REMARK 465 THR M 201 REMARK 465 LYS M 202 REMARK 465 SER M 203 REMARK 465 PHE M 204 REMARK 465 ASN M 205 REMARK 465 ARG M 206 REMARK 465 GLY M 207 REMARK 465 GLU M 208 REMARK 465 CYS M 209 REMARK 465 SER N 112 REMARK 465 SER N 113 REMARK 465 ALA N 114 REMARK 465 SER N 115 REMARK 465 THR N 116 REMARK 465 LYS N 117 REMARK 465 GLY N 118 REMARK 465 PRO N 119 REMARK 465 SER N 120 REMARK 465 VAL N 121 REMARK 465 PHE N 122 REMARK 465 PRO N 123 REMARK 465 LEU N 124 REMARK 465 ALA N 125 REMARK 465 PRO N 126 REMARK 465 SER N 127 REMARK 465 SER N 128 REMARK 465 LYS N 129 REMARK 465 SER N 130 REMARK 465 THR N 131 REMARK 465 SER N 132 REMARK 465 SER N 133 REMARK 465 GLY N 134 REMARK 465 GLY N 135 REMARK 465 THR N 136 REMARK 465 ALA N 137 REMARK 465 ALA N 138 REMARK 465 LEU N 139 REMARK 465 GLY N 140 REMARK 465 CYS N 141 REMARK 465 LEU N 142 REMARK 465 VAL N 143 REMARK 465 LYS N 144 REMARK 465 ASP N 145 REMARK 465 TYR N 146 REMARK 465 PHE N 147 REMARK 465 PRO N 148 REMARK 465 GLU N 149 REMARK 465 PRO N 150 REMARK 465 VAL N 151 REMARK 465 THR N 152 REMARK 465 VAL N 153 REMARK 465 SER N 154 REMARK 465 TRP N 155 REMARK 465 ASN N 156 REMARK 465 SER N 157 REMARK 465 GLY N 158 REMARK 465 ALA N 159 REMARK 465 LEU N 160 REMARK 465 THR N 161 REMARK 465 SER N 162 REMARK 465 GLY N 163 REMARK 465 VAL N 164 REMARK 465 HIS N 165 REMARK 465 THR N 166 REMARK 465 PHE N 167 REMARK 465 PRO N 168 REMARK 465 ALA N 169 REMARK 465 VAL N 170 REMARK 465 LEU N 171 REMARK 465 GLN N 172 REMARK 465 SER N 173 REMARK 465 SER N 174 REMARK 465 GLY N 175 REMARK 465 LEU N 176 REMARK 465 TYR N 177 REMARK 465 SER N 178 REMARK 465 LEU N 179 REMARK 465 SER N 180 REMARK 465 SER N 181 REMARK 465 VAL N 182 REMARK 465 VAL N 183 REMARK 465 THR N 184 REMARK 465 VAL N 185 REMARK 465 PRO N 186 REMARK 465 SER N 187 REMARK 465 SER N 188 REMARK 465 SER N 189 REMARK 465 LEU N 190 REMARK 465 GLY N 191 REMARK 465 THR N 192 REMARK 465 GLN N 193 REMARK 465 THR N 194 REMARK 465 TYR N 195 REMARK 465 ILE N 196 REMARK 465 CYS N 197 REMARK 465 ASN N 198 REMARK 465 VAL N 199 REMARK 465 ASN N 200 REMARK 465 HIS N 201 REMARK 465 LYS N 202 REMARK 465 PRO N 203 REMARK 465 SER N 204 REMARK 465 ASN N 205 REMARK 465 THR N 206 REMARK 465 LYS N 207 REMARK 465 VAL N 208 REMARK 465 ASP N 209 REMARK 465 LYS N 210 REMARK 465 LYS N 211 REMARK 465 VAL N 212 REMARK 465 GLU N 213 REMARK 465 PRO N 214 REMARK 465 LYS N 215 REMARK 465 SER N 216 REMARK 465 CYS N 217 REMARK 465 ASP N 218 REMARK 465 SER O 113 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 ARG O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 LYS O 214 REMARK 465 SER O 215 REMARK 465 CYS O 216 REMARK 465 ARG P 108 REMARK 465 THR P 109 REMARK 465 VAL P 110 REMARK 465 ALA P 111 REMARK 465 ALA P 112 REMARK 465 PRO P 113 REMARK 465 SER P 114 REMARK 465 VAL P 115 REMARK 465 PHE P 116 REMARK 465 ILE P 117 REMARK 465 PHE P 118 REMARK 465 PRO P 119 REMARK 465 PRO P 120 REMARK 465 SER P 121 REMARK 465 ASP P 122 REMARK 465 GLU P 123 REMARK 465 GLN P 124 REMARK 465 LEU P 125 REMARK 465 LYS P 126 REMARK 465 SER P 127 REMARK 465 GLY P 128 REMARK 465 THR P 129 REMARK 465 ALA P 130 REMARK 465 SER P 131 REMARK 465 VAL P 132 REMARK 465 VAL P 133 REMARK 465 CYS P 134 REMARK 465 LEU P 135 REMARK 465 LEU P 136 REMARK 465 ASN P 137 REMARK 465 ASN P 138 REMARK 465 PHE P 139 REMARK 465 TYR P 140 REMARK 465 PRO P 141 REMARK 465 ARG P 142 REMARK 465 GLU P 143 REMARK 465 ALA P 144 REMARK 465 LYS P 145 REMARK 465 VAL P 146 REMARK 465 GLN P 147 REMARK 465 TRP P 148 REMARK 465 LYS P 149 REMARK 465 VAL P 150 REMARK 465 ASP P 151 REMARK 465 ASN P 152 REMARK 465 ALA P 153 REMARK 465 LEU P 154 REMARK 465 GLN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ASN P 158 REMARK 465 SER P 159 REMARK 465 GLN P 160 REMARK 465 GLU P 161 REMARK 465 SER P 162 REMARK 465 VAL P 163 REMARK 465 THR P 164 REMARK 465 GLU P 165 REMARK 465 GLN P 166 REMARK 465 ASP P 167 REMARK 465 SER P 168 REMARK 465 LYS P 169 REMARK 465 ASP P 170 REMARK 465 SER P 171 REMARK 465 THR P 172 REMARK 465 TYR P 173 REMARK 465 SER P 174 REMARK 465 LEU P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 THR P 178 REMARK 465 LEU P 179 REMARK 465 THR P 180 REMARK 465 LEU P 181 REMARK 465 SER P 182 REMARK 465 LYS P 183 REMARK 465 ALA P 184 REMARK 465 ASP P 185 REMARK 465 TYR P 186 REMARK 465 GLU P 187 REMARK 465 LYS P 188 REMARK 465 HIS P 189 REMARK 465 LYS P 190 REMARK 465 VAL P 191 REMARK 465 TYR P 192 REMARK 465 ALA P 193 REMARK 465 CYS P 194 REMARK 465 GLU P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLN P 199 REMARK 465 GLY P 200 REMARK 465 LEU P 201 REMARK 465 SER P 202 REMARK 465 SER P 203 REMARK 465 PRO P 204 REMARK 465 VAL P 205 REMARK 465 THR P 206 REMARK 465 LYS P 207 REMARK 465 SER P 208 REMARK 465 PHE P 209 REMARK 465 ASN P 210 REMARK 465 ARG P 211 REMARK 465 GLY P 212 REMARK 465 GLU P 213 REMARK 465 CYS P 214 REMARK 465 GLU Q 185A REMARK 465 ASN Q 185B REMARK 465 GLN Q 185C REMARK 465 GLY Q 185D REMARK 465 ASN Q 185E REMARK 465 ARG Q 185F REMARK 465 SER Q 185G REMARK 465 ASN Q 185H REMARK 465 ASN Q 185I REMARK 465 THR Q 400 REMARK 465 SER Q 401 REMARK 465 VAL Q 402 REMARK 465 GLN Q 403 REMARK 465 GLY Q 404 REMARK 465 SER Q 405 REMARK 465 ASN Q 406 REMARK 465 SER Q 407 REMARK 465 THR Q 408 REMARK 465 GLY Q 409 REMARK 465 SER Q 410 REMARK 465 VAL Q 506 REMARK 465 GLY Q 507 REMARK 465 ARG Q 508 REMARK 465 ARG Q 509 REMARK 465 ARG Q 510 REMARK 465 ARG Q 511 REMARK 465 ARG Q 512 REMARK 465 ILE R 548 REMARK 465 VAL R 549 REMARK 465 GLN R 550 REMARK 465 GLN R 551 REMARK 465 GLN R 552 REMARK 465 SER R 553 REMARK 465 ASN R 554 REMARK 465 LEU R 555 REMARK 465 LEU R 556 REMARK 465 ARG R 557 REMARK 465 ALA R 558 REMARK 465 PRO R 559 REMARK 465 GLU R 560 REMARK 465 ALA R 561 REMARK 465 GLN R 562 REMARK 465 GLN R 563 REMARK 465 HIS R 564 REMARK 465 LEU R 565 REMARK 465 LEU R 566 REMARK 465 LYS R 567 REMARK 465 LEU R 568 REMARK 465 ALA S 112 REMARK 465 SER S 113 REMARK 465 THR S 114 REMARK 465 LYS S 115 REMARK 465 GLY S 116 REMARK 465 PRO S 117 REMARK 465 SER S 118 REMARK 465 VAL S 119 REMARK 465 PHE S 120 REMARK 465 PRO S 121 REMARK 465 LEU S 122 REMARK 465 ALA S 123 REMARK 465 PRO S 124 REMARK 465 SER S 125 REMARK 465 SER S 126 REMARK 465 LYS S 127 REMARK 465 SER S 128 REMARK 465 THR S 129 REMARK 465 SER S 130 REMARK 465 GLY S 131 REMARK 465 GLY S 132 REMARK 465 THR S 133 REMARK 465 ALA S 134 REMARK 465 ALA S 135 REMARK 465 LEU S 136 REMARK 465 GLY S 137 REMARK 465 CYS S 138 REMARK 465 LEU S 139 REMARK 465 VAL S 140 REMARK 465 LYS S 141 REMARK 465 ASP S 142 REMARK 465 TYR S 143 REMARK 465 PHE S 144 REMARK 465 PRO S 145 REMARK 465 GLU S 146 REMARK 465 PRO S 147 REMARK 465 VAL S 148 REMARK 465 THR S 149 REMARK 465 VAL S 150 REMARK 465 SER S 151 REMARK 465 TRP S 152 REMARK 465 ASN S 153 REMARK 465 SER S 154 REMARK 465 GLY S 155 REMARK 465 ALA S 156 REMARK 465 LEU S 157 REMARK 465 THR S 158 REMARK 465 SER S 159 REMARK 465 GLY S 160 REMARK 465 VAL S 161 REMARK 465 HIS S 162 REMARK 465 THR S 163 REMARK 465 PHE S 164 REMARK 465 PRO S 165 REMARK 465 ALA S 166 REMARK 465 VAL S 167 REMARK 465 LEU S 168 REMARK 465 GLN S 169 REMARK 465 SER S 170 REMARK 465 SER S 171 REMARK 465 GLY S 172 REMARK 465 LEU S 173 REMARK 465 TYR S 174 REMARK 465 SER S 175 REMARK 465 LEU S 176 REMARK 465 SER S 177 REMARK 465 SER S 178 REMARK 465 VAL S 179 REMARK 465 VAL S 180 REMARK 465 THR S 181 REMARK 465 VAL S 182 REMARK 465 PRO S 183 REMARK 465 SER S 184 REMARK 465 SER S 185 REMARK 465 SER S 186 REMARK 465 LEU S 187 REMARK 465 GLY S 188 REMARK 465 THR S 189 REMARK 465 GLN S 190 REMARK 465 THR S 191 REMARK 465 TYR S 192 REMARK 465 ILE S 193 REMARK 465 CYS S 194 REMARK 465 ASN S 195 REMARK 465 VAL S 196 REMARK 465 ASN S 197 REMARK 465 HIS S 198 REMARK 465 LYS S 199 REMARK 465 PRO S 200 REMARK 465 SER S 201 REMARK 465 ASN S 202 REMARK 465 THR S 203 REMARK 465 LYS S 204 REMARK 465 VAL S 205 REMARK 465 ASP S 206 REMARK 465 LYS S 207 REMARK 465 ARG S 208 REMARK 465 VAL S 209 REMARK 465 GLU S 210 REMARK 465 PRO S 211 REMARK 465 LYS S 212 REMARK 465 SER S 213 REMARK 465 CYS S 214 REMARK 465 ALA T 6 REMARK 465 PRO T 7 REMARK 465 SER T 108 REMARK 465 GLN T 109 REMARK 465 PRO T 110 REMARK 465 LYS T 111 REMARK 465 ALA T 112 REMARK 465 ALA T 113 REMARK 465 PRO T 114 REMARK 465 SER T 115 REMARK 465 VAL T 116 REMARK 465 THR T 117 REMARK 465 LEU T 118 REMARK 465 PHE T 119 REMARK 465 PRO T 120 REMARK 465 PRO T 121 REMARK 465 SER T 122 REMARK 465 SER T 123 REMARK 465 GLU T 124 REMARK 465 GLU T 125 REMARK 465 LEU T 126 REMARK 465 GLN T 127 REMARK 465 ALA T 128 REMARK 465 ASN T 129 REMARK 465 LYS T 130 REMARK 465 ALA T 131 REMARK 465 THR T 132 REMARK 465 LEU T 133 REMARK 465 VAL T 134 REMARK 465 CYS T 135 REMARK 465 LEU T 136 REMARK 465 ILE T 137 REMARK 465 SER T 138 REMARK 465 ASP T 139 REMARK 465 PHE T 140 REMARK 465 TYR T 141 REMARK 465 PRO T 142 REMARK 465 GLY T 143 REMARK 465 ALA T 144 REMARK 465 VAL T 145 REMARK 465 THR T 146 REMARK 465 VAL T 147 REMARK 465 ALA T 148 REMARK 465 TRP T 149 REMARK 465 LYS T 150 REMARK 465 ALA T 151 REMARK 465 ASP T 152 REMARK 465 SER T 153 REMARK 465 SER T 154 REMARK 465 PRO T 155 REMARK 465 VAL T 156 REMARK 465 LYS T 157 REMARK 465 ALA T 158 REMARK 465 GLY T 159 REMARK 465 VAL T 160 REMARK 465 GLU T 161 REMARK 465 THR T 162 REMARK 465 THR T 163 REMARK 465 THR T 164 REMARK 465 PRO T 165 REMARK 465 SER T 166 REMARK 465 LYS T 167 REMARK 465 GLN T 168 REMARK 465 SER T 169 REMARK 465 ASN T 170 REMARK 465 ASN T 171 REMARK 465 LYS T 172 REMARK 465 TYR T 173 REMARK 465 ALA T 174 REMARK 465 ALA T 175 REMARK 465 SER T 176 REMARK 465 SER T 177 REMARK 465 TYR T 178 REMARK 465 LEU T 179 REMARK 465 SER T 180 REMARK 465 LEU T 181 REMARK 465 THR T 182 REMARK 465 PRO T 183 REMARK 465 GLU T 184 REMARK 465 GLN T 185 REMARK 465 TRP T 186 REMARK 465 LYS T 187 REMARK 465 SER T 188 REMARK 465 HIS T 189 REMARK 465 LYS T 190 REMARK 465 SER T 191 REMARK 465 TYR T 192 REMARK 465 SER T 193 REMARK 465 CYS T 194 REMARK 465 GLN T 195 REMARK 465 VAL T 196 REMARK 465 THR T 197 REMARK 465 HIS T 198 REMARK 465 GLU T 199 REMARK 465 GLY T 200 REMARK 465 SER T 201 REMARK 465 THR T 202 REMARK 465 VAL T 203 REMARK 465 GLU T 204 REMARK 465 LYS T 205 REMARK 465 THR T 206 REMARK 465 VAL T 207 REMARK 465 ALA T 208 REMARK 465 PRO T 209 REMARK 465 THR T 210 REMARK 465 GLU T 211 REMARK 465 CYS T 212 REMARK 465 SER T 213 REMARK 465 ARG U 103 REMARK 465 THR U 104 REMARK 465 VAL U 105 REMARK 465 ALA U 106 REMARK 465 ALA U 107 REMARK 465 PRO U 108 REMARK 465 SER U 109 REMARK 465 VAL U 110 REMARK 465 PHE U 111 REMARK 465 ILE U 112 REMARK 465 PHE U 113 REMARK 465 PRO U 114 REMARK 465 PRO U 115 REMARK 465 SER U 116 REMARK 465 ASP U 117 REMARK 465 GLU U 118 REMARK 465 GLN U 119 REMARK 465 LEU U 120 REMARK 465 LYS U 121 REMARK 465 SER U 122 REMARK 465 GLY U 123 REMARK 465 THR U 124 REMARK 465 ALA U 125 REMARK 465 SER U 126 REMARK 465 VAL U 127 REMARK 465 VAL U 128 REMARK 465 CYS U 129 REMARK 465 LEU U 130 REMARK 465 LEU U 131 REMARK 465 ASN U 132 REMARK 465 ASN U 133 REMARK 465 PHE U 134 REMARK 465 TYR U 135 REMARK 465 PRO U 136 REMARK 465 ARG U 137 REMARK 465 GLU U 138 REMARK 465 ALA U 139 REMARK 465 LYS U 140 REMARK 465 VAL U 141 REMARK 465 GLN U 142 REMARK 465 TRP U 143 REMARK 465 LYS U 144 REMARK 465 VAL U 145 REMARK 465 ASP U 146 REMARK 465 ASN U 147 REMARK 465 ALA U 148 REMARK 465 LEU U 149 REMARK 465 GLN U 150 REMARK 465 SER U 151 REMARK 465 GLY U 152 REMARK 465 ASN U 153 REMARK 465 SER U 154 REMARK 465 GLN U 155 REMARK 465 GLU U 156 REMARK 465 SER U 157 REMARK 465 VAL U 158 REMARK 465 THR U 159 REMARK 465 GLU U 160 REMARK 465 GLN U 161 REMARK 465 ASP U 162 REMARK 465 SER U 163 REMARK 465 LYS U 164 REMARK 465 ASP U 165 REMARK 465 SER U 166 REMARK 465 THR U 167 REMARK 465 TYR U 168 REMARK 465 SER U 169 REMARK 465 LEU U 170 REMARK 465 SER U 171 REMARK 465 SER U 172 REMARK 465 THR U 173 REMARK 465 LEU U 174 REMARK 465 THR U 175 REMARK 465 LEU U 176 REMARK 465 SER U 177 REMARK 465 LYS U 178 REMARK 465 ALA U 179 REMARK 465 ASP U 180 REMARK 465 TYR U 181 REMARK 465 GLU U 182 REMARK 465 LYS U 183 REMARK 465 HIS U 184 REMARK 465 LYS U 185 REMARK 465 VAL U 186 REMARK 465 TYR U 187 REMARK 465 ALA U 188 REMARK 465 CYS U 189 REMARK 465 GLU U 190 REMARK 465 VAL U 191 REMARK 465 THR U 192 REMARK 465 HIS U 193 REMARK 465 GLN U 194 REMARK 465 GLY U 195 REMARK 465 LEU U 196 REMARK 465 SER U 197 REMARK 465 SER U 198 REMARK 465 PRO U 199 REMARK 465 VAL U 200 REMARK 465 THR U 201 REMARK 465 LYS U 202 REMARK 465 SER U 203 REMARK 465 PHE U 204 REMARK 465 ASN U 205 REMARK 465 ARG U 206 REMARK 465 GLY U 207 REMARK 465 GLU U 208 REMARK 465 CYS U 209 REMARK 465 SER V 112 REMARK 465 SER V 113 REMARK 465 ALA V 114 REMARK 465 SER V 115 REMARK 465 THR V 116 REMARK 465 LYS V 117 REMARK 465 GLY V 118 REMARK 465 PRO V 119 REMARK 465 SER V 120 REMARK 465 VAL V 121 REMARK 465 PHE V 122 REMARK 465 PRO V 123 REMARK 465 LEU V 124 REMARK 465 ALA V 125 REMARK 465 PRO V 126 REMARK 465 SER V 127 REMARK 465 SER V 128 REMARK 465 LYS V 129 REMARK 465 SER V 130 REMARK 465 THR V 131 REMARK 465 SER V 132 REMARK 465 SER V 133 REMARK 465 GLY V 134 REMARK 465 GLY V 135 REMARK 465 THR V 136 REMARK 465 ALA V 137 REMARK 465 ALA V 138 REMARK 465 LEU V 139 REMARK 465 GLY V 140 REMARK 465 CYS V 141 REMARK 465 LEU V 142 REMARK 465 VAL V 143 REMARK 465 LYS V 144 REMARK 465 ASP V 145 REMARK 465 TYR V 146 REMARK 465 PHE V 147 REMARK 465 PRO V 148 REMARK 465 GLU V 149 REMARK 465 PRO V 150 REMARK 465 VAL V 151 REMARK 465 THR V 152 REMARK 465 VAL V 153 REMARK 465 SER V 154 REMARK 465 TRP V 155 REMARK 465 ASN V 156 REMARK 465 SER V 157 REMARK 465 GLY V 158 REMARK 465 ALA V 159 REMARK 465 LEU V 160 REMARK 465 THR V 161 REMARK 465 SER V 162 REMARK 465 GLY V 163 REMARK 465 VAL V 164 REMARK 465 HIS V 165 REMARK 465 THR V 166 REMARK 465 PHE V 167 REMARK 465 PRO V 168 REMARK 465 ALA V 169 REMARK 465 VAL V 170 REMARK 465 LEU V 171 REMARK 465 GLN V 172 REMARK 465 SER V 173 REMARK 465 SER V 174 REMARK 465 GLY V 175 REMARK 465 LEU V 176 REMARK 465 TYR V 177 REMARK 465 SER V 178 REMARK 465 LEU V 179 REMARK 465 SER V 180 REMARK 465 SER V 181 REMARK 465 VAL V 182 REMARK 465 VAL V 183 REMARK 465 THR V 184 REMARK 465 VAL V 185 REMARK 465 PRO V 186 REMARK 465 SER V 187 REMARK 465 SER V 188 REMARK 465 SER V 189 REMARK 465 LEU V 190 REMARK 465 GLY V 191 REMARK 465 THR V 192 REMARK 465 GLN V 193 REMARK 465 THR V 194 REMARK 465 TYR V 195 REMARK 465 ILE V 196 REMARK 465 CYS V 197 REMARK 465 ASN V 198 REMARK 465 VAL V 199 REMARK 465 ASN V 200 REMARK 465 HIS V 201 REMARK 465 LYS V 202 REMARK 465 PRO V 203 REMARK 465 SER V 204 REMARK 465 ASN V 205 REMARK 465 THR V 206 REMARK 465 LYS V 207 REMARK 465 VAL V 208 REMARK 465 ASP V 209 REMARK 465 LYS V 210 REMARK 465 LYS V 211 REMARK 465 VAL V 212 REMARK 465 GLU V 213 REMARK 465 PRO V 214 REMARK 465 LYS V 215 REMARK 465 SER V 216 REMARK 465 CYS V 217 REMARK 465 ASP V 218 REMARK 465 SER W 113 REMARK 465 ALA W 114 REMARK 465 SER W 115 REMARK 465 THR W 116 REMARK 465 LYS W 117 REMARK 465 GLY W 118 REMARK 465 PRO W 119 REMARK 465 SER W 120 REMARK 465 VAL W 121 REMARK 465 PHE W 122 REMARK 465 PRO W 123 REMARK 465 LEU W 124 REMARK 465 ALA W 125 REMARK 465 PRO W 126 REMARK 465 SER W 127 REMARK 465 SER W 128 REMARK 465 LYS W 129 REMARK 465 SER W 130 REMARK 465 THR W 131 REMARK 465 SER W 132 REMARK 465 GLY W 133 REMARK 465 GLY W 134 REMARK 465 THR W 135 REMARK 465 ALA W 136 REMARK 465 ALA W 137 REMARK 465 LEU W 138 REMARK 465 GLY W 139 REMARK 465 CYS W 140 REMARK 465 LEU W 141 REMARK 465 VAL W 142 REMARK 465 LYS W 143 REMARK 465 ASP W 144 REMARK 465 TYR W 145 REMARK 465 PHE W 146 REMARK 465 PRO W 147 REMARK 465 GLU W 148 REMARK 465 PRO W 149 REMARK 465 VAL W 150 REMARK 465 THR W 151 REMARK 465 VAL W 152 REMARK 465 SER W 153 REMARK 465 TRP W 154 REMARK 465 ASN W 155 REMARK 465 SER W 156 REMARK 465 GLY W 157 REMARK 465 ALA W 158 REMARK 465 LEU W 159 REMARK 465 THR W 160 REMARK 465 SER W 161 REMARK 465 GLY W 162 REMARK 465 VAL W 163 REMARK 465 HIS W 164 REMARK 465 THR W 165 REMARK 465 PHE W 166 REMARK 465 PRO W 167 REMARK 465 ALA W 168 REMARK 465 VAL W 169 REMARK 465 LEU W 170 REMARK 465 GLN W 171 REMARK 465 SER W 172 REMARK 465 SER W 173 REMARK 465 GLY W 174 REMARK 465 LEU W 175 REMARK 465 TYR W 176 REMARK 465 SER W 177 REMARK 465 LEU W 178 REMARK 465 SER W 179 REMARK 465 SER W 180 REMARK 465 VAL W 181 REMARK 465 VAL W 182 REMARK 465 THR W 183 REMARK 465 VAL W 184 REMARK 465 PRO W 185 REMARK 465 SER W 186 REMARK 465 SER W 187 REMARK 465 SER W 188 REMARK 465 LEU W 189 REMARK 465 GLY W 190 REMARK 465 THR W 191 REMARK 465 GLN W 192 REMARK 465 THR W 193 REMARK 465 TYR W 194 REMARK 465 ILE W 195 REMARK 465 CYS W 196 REMARK 465 ASN W 197 REMARK 465 VAL W 198 REMARK 465 ASN W 199 REMARK 465 HIS W 200 REMARK 465 LYS W 201 REMARK 465 PRO W 202 REMARK 465 SER W 203 REMARK 465 ASN W 204 REMARK 465 THR W 205 REMARK 465 LYS W 206 REMARK 465 VAL W 207 REMARK 465 ASP W 208 REMARK 465 LYS W 209 REMARK 465 ARG W 210 REMARK 465 VAL W 211 REMARK 465 GLU W 212 REMARK 465 PRO W 213 REMARK 465 LYS W 214 REMARK 465 SER W 215 REMARK 465 CYS W 216 REMARK 465 ARG X 108 REMARK 465 THR X 109 REMARK 465 VAL X 110 REMARK 465 ALA X 111 REMARK 465 ALA X 112 REMARK 465 PRO X 113 REMARK 465 SER X 114 REMARK 465 VAL X 115 REMARK 465 PHE X 116 REMARK 465 ILE X 117 REMARK 465 PHE X 118 REMARK 465 PRO X 119 REMARK 465 PRO X 120 REMARK 465 SER X 121 REMARK 465 ASP X 122 REMARK 465 GLU X 123 REMARK 465 GLN X 124 REMARK 465 LEU X 125 REMARK 465 LYS X 126 REMARK 465 SER X 127 REMARK 465 GLY X 128 REMARK 465 THR X 129 REMARK 465 ALA X 130 REMARK 465 SER X 131 REMARK 465 VAL X 132 REMARK 465 VAL X 133 REMARK 465 CYS X 134 REMARK 465 LEU X 135 REMARK 465 LEU X 136 REMARK 465 ASN X 137 REMARK 465 ASN X 138 REMARK 465 PHE X 139 REMARK 465 TYR X 140 REMARK 465 PRO X 141 REMARK 465 ARG X 142 REMARK 465 GLU X 143 REMARK 465 ALA X 144 REMARK 465 LYS X 145 REMARK 465 VAL X 146 REMARK 465 GLN X 147 REMARK 465 TRP X 148 REMARK 465 LYS X 149 REMARK 465 VAL X 150 REMARK 465 ASP X 151 REMARK 465 ASN X 152 REMARK 465 ALA X 153 REMARK 465 LEU X 154 REMARK 465 GLN X 155 REMARK 465 SER X 156 REMARK 465 GLY X 157 REMARK 465 ASN X 158 REMARK 465 SER X 159 REMARK 465 GLN X 160 REMARK 465 GLU X 161 REMARK 465 SER X 162 REMARK 465 VAL X 163 REMARK 465 THR X 164 REMARK 465 GLU X 165 REMARK 465 GLN X 166 REMARK 465 ASP X 167 REMARK 465 SER X 168 REMARK 465 LYS X 169 REMARK 465 ASP X 170 REMARK 465 SER X 171 REMARK 465 THR X 172 REMARK 465 TYR X 173 REMARK 465 SER X 174 REMARK 465 LEU X 175 REMARK 465 SER X 176 REMARK 465 SER X 177 REMARK 465 THR X 178 REMARK 465 LEU X 179 REMARK 465 THR X 180 REMARK 465 LEU X 181 REMARK 465 SER X 182 REMARK 465 LYS X 183 REMARK 465 ALA X 184 REMARK 465 ASP X 185 REMARK 465 TYR X 186 REMARK 465 GLU X 187 REMARK 465 LYS X 188 REMARK 465 HIS X 189 REMARK 465 LYS X 190 REMARK 465 VAL X 191 REMARK 465 TYR X 192 REMARK 465 ALA X 193 REMARK 465 CYS X 194 REMARK 465 GLU X 195 REMARK 465 VAL X 196 REMARK 465 THR X 197 REMARK 465 HIS X 198 REMARK 465 GLN X 199 REMARK 465 GLY X 200 REMARK 465 LEU X 201 REMARK 465 SER X 202 REMARK 465 SER X 203 REMARK 465 PRO X 204 REMARK 465 VAL X 205 REMARK 465 THR X 206 REMARK 465 LYS X 207 REMARK 465 SER X 208 REMARK 465 PHE X 209 REMARK 465 ASN X 210 REMARK 465 ARG X 211 REMARK 465 GLY X 212 REMARK 465 GLU X 213 REMARK 465 CYS X 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 ND2 ASN G 392 O5 NAG G 643 2.15 REMARK 500 ND2 ASN Q 392 O5 NAG Q 643 2.15 REMARK 500 ND2 ASN A 392 O5 NAG A 643 2.15 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 54 CA - CB - SG ANGL. DEV. = 8.1 DEGREES REMARK 500 CYS A 433 CA - CB - SG ANGL. DEV. = 7.7 DEGREES REMARK 500 CYS G 54 CA - CB - SG ANGL. DEV. = 8.1 DEGREES REMARK 500 CYS G 433 CA - CB - SG ANGL. DEV. = 7.8 DEGREES REMARK 500 PRO H 29 C - N - CD ANGL. DEV. = -14.9 DEGREES REMARK 500 ASP H 72 CB - CG - OD1 ANGL. DEV. = 5.6 DEGREES REMARK 500 LEU H 79 CA - CB - CG ANGL. DEV. = 20.4 DEGREES REMARK 500 LEU H 108 CA - CB - CG ANGL. DEV. = 17.9 DEGREES REMARK 500 ASP L 30A CB - CG - OD1 ANGL. DEV. = 5.5 DEGREES REMARK 500 ASP L 82 CB - CG - OD1 ANGL. DEV. = 6.5 DEGREES REMARK 500 PRO O 29 C - N - CD ANGL. DEV. = -14.9 DEGREES REMARK 500 ASP O 72 CB - CG - OD1 ANGL. DEV. = 5.6 DEGREES REMARK 500 LEU O 79 CA - CB - CG ANGL. DEV. = 20.4 DEGREES REMARK 500 LEU O 108 CA - CB - CG ANGL. DEV. = 17.9 DEGREES REMARK 500 ASP P 30A CB - CG - OD1 ANGL. DEV. = 5.4 DEGREES REMARK 500 ASP P 82 CB - CG - OD1 ANGL. DEV. = 6.4 DEGREES REMARK 500 CYS Q 54 CA - CB - SG ANGL. DEV. = 8.1 DEGREES REMARK 500 CYS Q 433 CA - CB - SG ANGL. DEV. = 7.7 DEGREES REMARK 500 PRO W 29 C - N - CD ANGL. DEV. = -14.9 DEGREES REMARK 500 ASP W 72 CB - CG - OD1 ANGL. DEV. = 5.6 DEGREES REMARK 500 LEU W 79 CA - CB - CG ANGL. DEV. = 20.5 DEGREES REMARK 500 LEU W 108 CA - CB - CG ANGL. DEV. = 17.9 DEGREES REMARK 500 ASP X 30A CB - CG - OD1 ANGL. DEV. = 5.4 DEGREES REMARK 500 ASP X 82 CB - CG - OD1 ANGL. DEV. = 6.4 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 80 70.57 34.90 REMARK 500 MET A 100 -0.35 64.68 REMARK 500 THR A 135 97.84 -68.33 REMARK 500 LYS A 231 -63.17 -90.11 REMARK 500 THR A 257 -64.81 -92.74 REMARK 500 GLU A 268 -40.71 -131.72 REMARK 500 TRP A 427 -3.04 68.92 REMARK 500 SER A 460 -168.91 -103.43 REMARK 500 THR A 461 62.81 62.02 REMARK 500 PRO A 493 -162.89 -76.97 REMARK 500 LEU A 494 64.69 66.68 REMARK 500 LEU B 520 59.57 34.64 REMARK 500 ASN B 543 51.45 -92.79 REMARK 500 LEU B 602 -13.57 72.59 REMARK 500 THR B 606 -169.36 -123.26 REMARK 500 GLN B 640 -8.19 70.11 REMARK 500 PRO C 100E 79.39 -65.41 REMARK 500 THR D 50 -8.82 69.16 REMARK 500 LEU E 63 -73.41 -84.12 REMARK 500 LYS E 64 -20.08 65.27 REMARK 500 SER E 65 -23.71 -140.96 REMARK 500 GLU E 100I 73.96 -100.93 REMARK 500 ASN F 50 -159.13 -141.61 REMARK 500 PRO F 59 -168.47 -77.31 REMARK 500 ARG F 61 -2.35 68.51 REMARK 500 PRO F 95A -179.76 -67.88 REMARK 500 ASN G 80 70.69 34.71 REMARK 500 MET G 100 -0.45 64.73 REMARK 500 THR G 135 97.82 -68.23 REMARK 500 LYS G 231 -63.18 -90.19 REMARK 500 THR G 257 -64.79 -92.76 REMARK 500 GLU G 268 -40.61 -131.75 REMARK 500 TRP G 427 -3.25 68.92 REMARK 500 SER G 460 -168.77 -103.54 REMARK 500 THR G 461 62.97 61.86 REMARK 500 PRO G 493 -162.77 -76.98 REMARK 500 LEU G 494 64.69 66.69 REMARK 500 ASN H 76 57.58 35.07 REMARK 500 LEU I 520 59.78 34.48 REMARK 500 ASN I 543 51.53 -92.88 REMARK 500 LEU I 602 -13.44 72.49 REMARK 500 THR I 606 -169.35 -123.20 REMARK 500 GLN I 640 -8.03 70.05 REMARK 500 LEU J 63 -73.45 -84.22 REMARK 500 LYS J 64 -20.07 65.26 REMARK 500 SER J 65 -23.81 -140.95 REMARK 500 GLU J 100I 74.08 -101.00 REMARK 500 ASN K 50 -159.22 -141.61 REMARK 500 PRO K 59 -168.46 -77.38 REMARK 500 ARG K 61 -2.30 68.50 REMARK 500 REMARK 500 THIS ENTRY HAS 96 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 ASP L 50 VAL L 51 -119.37 REMARK 500 ASP P 50 VAL P 51 -119.38 REMARK 500 ASP X 50 VAL X 51 -119.47 REMARK 500 REMARK 500 REMARK: NULL REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 601 through NAG A 602 bound to ASN A 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 603 through NAG A 604 bound to ASN A 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 605 through MAN A 608 bound to ASN A 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 609 through MAN A 613 bound to ASN A 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 614 through BMA A 616 bound to ASN A 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 617 through MAN A 620 bound to ASN A 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 621 through BMA A 623 bound to ASN A 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 624 through MAN A 629 bound to ASN A 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 657 through MAN A 660 bound to ASN A 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 630 through NAG A 631 bound to ASN A 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 632 through NAG A 633 bound to ASN A 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 645 through MAN A 653 bound to ASN A 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG A 634 bound REMARK 800 to ASN A 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 635 through BMA A 637 bound to ASN A 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 638 through MAN A 642 bound to ASN A 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 643 through NAG A 644 bound to ASN A 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A REMARK 800 654 through BMA A 656 bound to ASN A 448 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 702 bound REMARK 800 to ASN B 611 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 701 bound REMARK 800 to ASN B 637 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 601 through NAG G 602 bound to ASN G 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 603 through NAG G 604 bound to ASN G 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 605 through MAN G 608 bound to ASN G 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 609 through MAN G 613 bound to ASN G 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 614 through BMA G 616 bound to ASN G 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 617 through MAN G 620 bound to ASN G 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 621 through BMA G 623 bound to ASN G 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 624 through MAN G 629 bound to ASN G 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 657 through MAN G 660 bound to ASN G 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 630 through NAG G 631 bound to ASN G 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 632 through NAG G 633 bound to ASN G 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 645 through MAN G 653 bound to ASN G 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG G 634 bound REMARK 800 to ASN G 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 635 through BMA G 637 bound to ASN G 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 638 through MAN G 642 bound to ASN G 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 643 through NAG G 644 bound to ASN G 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 654 through BMA G 656 bound to ASN G 448 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG I 702 bound REMARK 800 to ASN I 611 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG I 701 bound REMARK 800 to ASN I 637 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 601 through NAG Q 602 bound to ASN Q 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 603 through NAG Q 604 bound to ASN Q 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 605 through MAN Q 608 bound to ASN Q 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 609 through MAN Q 613 bound to ASN Q 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 614 through BMA Q 616 bound to ASN Q 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 617 through MAN Q 620 bound to ASN Q 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 621 through BMA Q 623 bound to ASN Q 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 624 through MAN Q 629 bound to ASN Q 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 657 through MAN Q 660 bound to ASN Q 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 630 through NAG Q 631 bound to ASN Q 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 632 through NAG Q 633 bound to ASN Q 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 645 through MAN Q 653 bound to ASN Q 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG Q 634 bound REMARK 800 to ASN Q 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 635 through BMA Q 637 bound to ASN Q 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 638 through MAN Q 642 bound to ASN Q 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 643 through NAG Q 644 bound to ASN Q 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG Q REMARK 800 654 through BMA Q 656 bound to ASN Q 448 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG R 702 bound REMARK 800 to ASN R 611 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG R 701 bound REMARK 800 to ASN R 637 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 6MQC RELATED DB: PDB REMARK 900 0PV-C.01 FAB WITH PEPTIDE REMARK 900 RELATED ID: EMD-9359 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY 0PV-C.01 IN COMPLEX REMARK 900 WITH HIV-1 ENV BG505 DS-SOSIP AND ANTIBODIES VRC03 AND PGT122 DBREF 6NF2 A 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 DBREF 6NF2 B 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6NF2 C 1 218 PDB 6NF2 6NF2 1 218 DBREF 6NF2 D 1 209 PDB 6NF2 6NF2 1 209 DBREF 6NF2 E 1 214 PDB 6NF2 6NF2 1 214 DBREF 6NF2 F 6 213 PDB 6NF2 6NF2 6 213 DBREF 6NF2 G 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 DBREF 6NF2 H 1 216 PDB 6NF2 6NF2 1 216 DBREF 6NF2 I 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6NF2 J 1 214 PDB 6NF2 6NF2 1 214 DBREF 6NF2 K 6 213 PDB 6NF2 6NF2 6 213 DBREF 6NF2 L 1 214 PDB 6NF2 6NF2 1 214 DBREF 6NF2 M 1 209 PDB 6NF2 6NF2 1 209 DBREF 6NF2 N 1 218 PDB 6NF2 6NF2 1 218 DBREF 6NF2 O 1 216 PDB 6NF2 6NF2 1 216 DBREF 6NF2 P 1 214 PDB 6NF2 6NF2 1 214 DBREF 6NF2 Q 31 512 UNP Q2N0S6 Q2N0S6_9HIV1 30 509 DBREF 6NF2 R 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6NF2 S 1 214 PDB 6NF2 6NF2 1 214 DBREF 6NF2 T 6 213 PDB 6NF2 6NF2 6 213 DBREF 6NF2 U 1 209 PDB 6NF2 6NF2 1 209 DBREF 6NF2 V 1 218 PDB 6NF2 6NF2 1 218 DBREF 6NF2 W 1 216 PDB 6NF2 6NF2 1 216 DBREF 6NF2 X 1 214 PDB 6NF2 6NF2 1 214 SEQADV 6NF2 CYS A 201 UNP Q2N0S6 ILE 200 ENGINEERED MUTATION SEQADV 6NF2 ASN A 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 6NF2 CYS A 433 UNP Q2N0S6 ALA 430 ENGINEERED MUTATION SEQADV 6NF2 CYS A 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 6NF2 ARG A 509 UNP Q2N0S6 GLU 506 ENGINEERED MUTATION SEQADV 6NF2 ARG A 510 UNP Q2N0S6 LYS 507 ENGINEERED MUTATION SEQADV 6NF2 ARG A 512 UNP Q2N0S6 ALA 509 ENGINEERED MUTATION SEQADV 6NF2 PRO B 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6NF2 CYS B 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 6NF2 CYS G 201 UNP Q2N0S6 ILE 200 ENGINEERED MUTATION SEQADV 6NF2 ASN G 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 6NF2 CYS G 433 UNP Q2N0S6 ALA 430 ENGINEERED MUTATION SEQADV 6NF2 CYS G 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 6NF2 ARG G 509 UNP Q2N0S6 GLU 506 ENGINEERED MUTATION SEQADV 6NF2 ARG G 510 UNP Q2N0S6 LYS 507 ENGINEERED MUTATION SEQADV 6NF2 ARG G 512 UNP Q2N0S6 ALA 509 ENGINEERED MUTATION SEQADV 6NF2 PRO I 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6NF2 CYS I 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 6NF2 CYS Q 201 UNP Q2N0S6 ILE 200 ENGINEERED MUTATION SEQADV 6NF2 ASN Q 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 6NF2 CYS Q 433 UNP Q2N0S6 ALA 430 ENGINEERED MUTATION SEQADV 6NF2 CYS Q 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 6NF2 ARG Q 509 UNP Q2N0S6 GLU 506 ENGINEERED MUTATION SEQADV 6NF2 ARG Q 510 UNP Q2N0S6 LYS 507 ENGINEERED MUTATION SEQADV 6NF2 ARG Q 512 UNP Q2N0S6 ALA 509 ENGINEERED MUTATION SEQADV 6NF2 PRO R 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6NF2 CYS R 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQRES 1 A 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 A 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 A 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 A 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 A 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 A 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 A 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 A 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 A 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 A 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 A 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 A 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 A 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 A 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 A 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 A 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 A 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 A 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 A 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 A 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 A 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 A 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 A 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 A 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 A 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 A 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 A 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 A 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 A 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 A 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 A 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 A 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 A 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 A 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 A 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 A 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 A 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 1 B 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 B 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 B 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 B 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 B 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 B 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 B 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 C 235 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 C 235 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 C 235 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 C 235 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 C 235 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 C 235 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 C 235 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 C 235 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 C 235 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 C 235 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 C 235 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 C 235 SER SER LYS SER THR SER SER GLY GLY THR ALA ALA LEU SEQRES 13 C 235 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 C 235 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 C 235 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 C 235 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 C 235 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 C 235 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 C 235 ASP SEQRES 1 D 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 D 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 D 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 D 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 D 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 D 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 D 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 D 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 D 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 D 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 D 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 D 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 D 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 D 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 D 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 D 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 D 209 CYS SEQRES 1 E 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 E 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 E 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 E 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 E 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 E 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 E 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 E 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 E 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 E 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 E 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 E 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 E 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 E 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 E 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 E 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 E 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 E 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 E 235 CYS SEQRES 1 F 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 F 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 F 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 F 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 F 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 F 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 F 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 F 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 F 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 F 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 F 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 F 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 F 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 F 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 F 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 F 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 F 213 PRO THR GLU CYS SER SEQRES 1 G 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 G 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 G 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 G 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 G 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 G 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 G 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 G 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 G 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 G 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 G 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 G 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 G 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 G 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 G 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 G 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 G 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 G 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 G 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 G 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 G 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 G 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 G 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 G 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 G 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 G 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 G 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 G 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 G 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 G 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 G 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 G 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 G 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 G 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 G 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 G 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 G 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 1 H 229 GLN VAL GLN LEU VAL GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 H 229 PRO SER GLU THR LEU SER LEU THR CYS VAL VAL SER GLY SEQRES 3 H 229 GLY THR PRO GLY ARG GLY PHE LEU TYR TRP SER TRP VAL SEQRES 4 H 229 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 H 229 THR ALA THR ASN THR ASP ILE THR ASP TYR ASN PRO SER SEQRES 6 H 229 LEU LYS SER ARG ALA ALA ILE SER LYS ASP THR SER ARG SEQRES 7 H 229 ASN GLN PHE LEU LEU ASN LEU LYS PRO LEU THR ALA GLY SEQRES 8 H 229 ASP THR ALA VAL TYR TYR CYS THR SER ARG ALA LYS ASP SEQRES 9 H 229 TYR ARG GLY PRO SER TYR SER ARG ILE ASP VAL TRP GLY SEQRES 10 H 229 PRO GLY VAL LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 H 229 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 H 229 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 H 229 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 H 229 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 H 229 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 H 229 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 H 229 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 H 229 LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 I 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 I 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 I 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 I 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 I 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 I 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 I 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 I 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 I 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 I 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 I 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 I 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 J 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 J 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 J 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 J 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 J 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 J 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 J 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 J 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 J 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 J 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 J 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 J 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 J 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 J 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 J 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 J 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 J 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 J 235 CYS SEQRES 1 K 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 K 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 K 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 K 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 K 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 K 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 K 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 K 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 K 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 K 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 K 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 K 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 K 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 K 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 K 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 K 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 K 213 PRO THR GLU CYS SER SEQRES 1 L 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 L 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 219 GLN SER LEU LEU ASP SER ASP GLY ASN THR CYS LEU ASP SEQRES 4 L 219 TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 L 219 ILE TYR ASP VAL SER ASN ARG VAL SER GLY VAL PRO ASP SEQRES 6 L 219 ARG PHE SER GLY SER GLY SER ASP THR ASP PHE THR LEU SEQRES 7 L 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 L 219 TYR CYS MET GLN PHE VAL GLU PHE PRO LEU THR PHE GLY SEQRES 9 L 219 GLY GLY THR LYS VAL GLU ILE ARG ARG THR VAL ALA ALA SEQRES 10 L 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 L 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 L 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 L 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 L 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 M 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 M 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 M 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 M 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 M 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 M 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 M 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 M 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 M 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 M 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 M 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 M 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 M 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 M 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 M 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 M 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 M 209 CYS SEQRES 1 N 235 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 N 235 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 N 235 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 N 235 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 N 235 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 N 235 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 N 235 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 N 235 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 N 235 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 N 235 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 N 235 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 N 235 SER SER LYS SER THR SER SER GLY GLY THR ALA ALA LEU SEQRES 13 N 235 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 N 235 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 N 235 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 N 235 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 N 235 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 N 235 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 N 235 ASP SEQRES 1 O 229 GLN VAL GLN LEU VAL GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 O 229 PRO SER GLU THR LEU SER LEU THR CYS VAL VAL SER GLY SEQRES 3 O 229 GLY THR PRO GLY ARG GLY PHE LEU TYR TRP SER TRP VAL SEQRES 4 O 229 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 O 229 THR ALA THR ASN THR ASP ILE THR ASP TYR ASN PRO SER SEQRES 6 O 229 LEU LYS SER ARG ALA ALA ILE SER LYS ASP THR SER ARG SEQRES 7 O 229 ASN GLN PHE LEU LEU ASN LEU LYS PRO LEU THR ALA GLY SEQRES 8 O 229 ASP THR ALA VAL TYR TYR CYS THR SER ARG ALA LYS ASP SEQRES 9 O 229 TYR ARG GLY PRO SER TYR SER ARG ILE ASP VAL TRP GLY SEQRES 10 O 229 PRO GLY VAL LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 O 229 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 O 229 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 O 229 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 O 229 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 O 229 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 O 229 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 O 229 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 O 229 LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 P 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 P 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 P 219 GLN SER LEU LEU ASP SER ASP GLY ASN THR CYS LEU ASP SEQRES 4 P 219 TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 P 219 ILE TYR ASP VAL SER ASN ARG VAL SER GLY VAL PRO ASP SEQRES 6 P 219 ARG PHE SER GLY SER GLY SER ASP THR ASP PHE THR LEU SEQRES 7 P 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 P 219 TYR CYS MET GLN PHE VAL GLU PHE PRO LEU THR PHE GLY SEQRES 9 P 219 GLY GLY THR LYS VAL GLU ILE ARG ARG THR VAL ALA ALA SEQRES 10 P 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 P 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 P 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 P 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 P 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 P 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 P 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 P 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 Q 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 Q 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 Q 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 Q 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 Q 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 Q 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 Q 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 Q 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 Q 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 Q 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 Q 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 Q 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 Q 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 Q 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 Q 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 Q 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 Q 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 Q 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 Q 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 Q 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 Q 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 Q 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 Q 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 Q 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 Q 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 Q 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 Q 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 Q 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 Q 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 Q 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 Q 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 Q 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 Q 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 Q 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 Q 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 Q 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 Q 480 CYS LYS ARG ARG VAL VAL GLY ARG ARG ARG ARG ARG SEQRES 1 R 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 R 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 R 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 R 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 R 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 R 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 R 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 R 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 R 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 R 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 R 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 R 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 S 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 S 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 S 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 S 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 S 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 S 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 S 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 S 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 S 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 S 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 S 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 S 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 S 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 S 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 S 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 S 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 S 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 S 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 S 235 CYS SEQRES 1 T 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 T 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 T 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 T 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 T 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 T 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 T 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 T 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 T 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 T 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 T 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 T 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 T 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 T 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 T 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 T 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 T 213 PRO THR GLU CYS SER SEQRES 1 U 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 U 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 U 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 U 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 U 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 U 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 U 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 U 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 U 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 U 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 U 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 U 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 U 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 U 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 U 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 U 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 U 209 CYS SEQRES 1 V 235 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 V 235 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 V 235 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 V 235 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 V 235 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 V 235 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 V 235 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 V 235 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 V 235 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 V 235 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 V 235 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 V 235 SER SER LYS SER THR SER SER GLY GLY THR ALA ALA LEU SEQRES 13 V 235 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 14 V 235 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 15 V 235 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 16 V 235 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 17 V 235 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 18 V 235 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 19 V 235 ASP SEQRES 1 W 229 GLN VAL GLN LEU VAL GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 W 229 PRO SER GLU THR LEU SER LEU THR CYS VAL VAL SER GLY SEQRES 3 W 229 GLY THR PRO GLY ARG GLY PHE LEU TYR TRP SER TRP VAL SEQRES 4 W 229 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 W 229 THR ALA THR ASN THR ASP ILE THR ASP TYR ASN PRO SER SEQRES 6 W 229 LEU LYS SER ARG ALA ALA ILE SER LYS ASP THR SER ARG SEQRES 7 W 229 ASN GLN PHE LEU LEU ASN LEU LYS PRO LEU THR ALA GLY SEQRES 8 W 229 ASP THR ALA VAL TYR TYR CYS THR SER ARG ALA LYS ASP SEQRES 9 W 229 TYR ARG GLY PRO SER TYR SER ARG ILE ASP VAL TRP GLY SEQRES 10 W 229 PRO GLY VAL LEU VAL THR VAL SER SER ALA SER THR LYS SEQRES 11 W 229 GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS SER SEQRES 12 W 229 THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS SEQRES 13 W 229 ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER SEQRES 14 W 229 GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL SEQRES 15 W 229 LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL VAL SEQRES 16 W 229 THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR ILE SEQRES 17 W 229 CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP SEQRES 18 W 229 LYS ARG VAL GLU PRO LYS SER CYS SEQRES 1 X 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU PRO VAL SEQRES 2 X 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 X 219 GLN SER LEU LEU ASP SER ASP GLY ASN THR CYS LEU ASP SEQRES 4 X 219 TRP PHE LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 X 219 ILE TYR ASP VAL SER ASN ARG VAL SER GLY VAL PRO ASP SEQRES 6 X 219 ARG PHE SER GLY SER GLY SER ASP THR ASP PHE THR LEU SEQRES 7 X 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 X 219 TYR CYS MET GLN PHE VAL GLU PHE PRO LEU THR PHE GLY SEQRES 9 X 219 GLY GLY THR LYS VAL GLU ILE ARG ARG THR VAL ALA ALA SEQRES 10 X 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 X 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 X 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 X 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 X 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 X 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 X 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 X 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET BMA A 607 11 HET MAN A 608 11 HET NAG A 609 14 HET NAG A 610 14 HET BMA A 611 11 HET MAN A 612 11 HET MAN A 613 11 HET NAG A 614 14 HET NAG A 615 14 HET BMA A 616 11 HET NAG A 617 14 HET NAG A 618 14 HET BMA A 619 11 HET MAN A 620 11 HET NAG A 621 14 HET NAG A 622 14 HET BMA A 623 11 HET NAG A 624 14 HET NAG A 625 14 HET BMA A 626 11 HET MAN A 627 11 HET MAN A 628 11 HET MAN A 629 11 HET NAG A 630 14 HET NAG A 631 14 HET NAG A 632 14 HET NAG A 633 14 HET NAG A 634 14 HET NAG A 635 14 HET NAG A 636 14 HET BMA A 637 11 HET NAG A 638 14 HET NAG A 639 14 HET BMA A 640 11 HET MAN A 641 11 HET MAN A 642 11 HET NAG A 643 14 HET NAG A 644 14 HET NAG A 645 14 HET NAG A 646 14 HET BMA A 647 11 HET MAN A 648 11 HET MAN A 649 11 HET MAN A 650 11 HET MAN A 651 11 HET MAN A 652 11 HET MAN A 653 11 HET NAG A 654 14 HET NAG A 655 14 HET BMA A 656 11 HET NAG A 657 14 HET NAG A 658 14 HET BMA A 659 11 HET MAN A 660 11 HET NAG B 701 14 HET NAG B 702 14 HET NAG G 601 14 HET NAG G 602 14 HET NAG G 603 14 HET NAG G 604 14 HET NAG G 605 14 HET NAG G 606 14 HET BMA G 607 11 HET MAN G 608 11 HET NAG G 609 14 HET NAG G 610 14 HET BMA G 611 11 HET MAN G 612 11 HET MAN G 613 11 HET NAG G 614 14 HET NAG G 615 14 HET BMA G 616 11 HET NAG G 617 14 HET NAG G 618 14 HET BMA G 619 11 HET MAN G 620 11 HET NAG G 621 14 HET NAG G 622 14 HET BMA G 623 11 HET NAG G 624 14 HET NAG G 625 14 HET BMA G 626 11 HET MAN G 627 11 HET MAN G 628 11 HET MAN G 629 11 HET NAG G 630 14 HET NAG G 631 14 HET NAG G 632 14 HET NAG G 633 14 HET NAG G 634 14 HET NAG G 635 14 HET NAG G 636 14 HET BMA G 637 11 HET NAG G 638 14 HET NAG G 639 14 HET BMA G 640 11 HET MAN G 641 11 HET MAN G 642 11 HET NAG G 643 14 HET NAG G 644 14 HET NAG G 645 14 HET NAG G 646 14 HET BMA G 647 11 HET MAN G 648 11 HET MAN G 649 11 HET MAN G 650 11 HET MAN G 651 11 HET MAN G 652 11 HET MAN G 653 11 HET NAG G 654 14 HET NAG G 655 14 HET BMA G 656 11 HET NAG G 657 14 HET NAG G 658 14 HET BMA G 659 11 HET MAN G 660 11 HET NAG I 701 14 HET NAG I 702 14 HET NAG Q 601 14 HET NAG Q 602 14 HET NAG Q 603 14 HET NAG Q 604 14 HET NAG Q 605 14 HET NAG Q 606 14 HET BMA Q 607 11 HET MAN Q 608 11 HET NAG Q 609 14 HET NAG Q 610 14 HET BMA Q 611 11 HET MAN Q 612 11 HET MAN Q 613 11 HET NAG Q 614 14 HET NAG Q 615 14 HET BMA Q 616 11 HET NAG Q 617 14 HET NAG Q 618 14 HET BMA Q 619 11 HET MAN Q 620 11 HET NAG Q 621 14 HET NAG Q 622 14 HET BMA Q 623 11 HET NAG Q 624 14 HET NAG Q 625 14 HET BMA Q 626 11 HET MAN Q 627 11 HET MAN Q 628 11 HET MAN Q 629 11 HET NAG Q 630 14 HET NAG Q 631 14 HET NAG Q 632 14 HET NAG Q 633 14 HET NAG Q 634 14 HET NAG Q 635 14 HET NAG Q 636 14 HET BMA Q 637 11 HET NAG Q 638 14 HET NAG Q 639 14 HET BMA Q 640 11 HET MAN Q 641 11 HET MAN Q 642 11 HET NAG Q 643 14 HET NAG Q 644 14 HET NAG Q 645 14 HET NAG Q 646 14 HET BMA Q 647 11 HET MAN Q 648 11 HET MAN Q 649 11 HET MAN Q 650 11 HET MAN Q 651 11 HET MAN Q 652 11 HET MAN Q 653 11 HET NAG Q 654 14 HET NAG Q 655 14 HET BMA Q 656 11 HET NAG Q 657 14 HET NAG Q 658 14 HET BMA Q 659 11 HET MAN Q 660 11 HET NAG R 701 14 HET NAG R 702 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 25 NAG 105(C8 H15 N O6) FORMUL 27 BMA 33(C6 H12 O6) FORMUL 27 MAN 48(C6 H12 O6) HELIX 1 AA1 ASP A 57 THR A 63 1 7 HELIX 2 AA2 VAL A 101 SER A 115 1 15 HELIX 3 AA3 LEU A 122 CYS A 126 5 5 HELIX 4 AA4 LYS A 335 ARG A 350 1 16 HELIX 5 AA5 LYS A 351 PHE A 353 5 3 HELIX 6 AA6 ASP A 368 THR A 373 1 6 HELIX 7 AA7 MET A 475 ARG A 480 1 6 HELIX 8 AA8 THR B 529 SER B 534 1 6 HELIX 9 AA9 LEU B 537 ASN B 543 1 7 HELIX 10 AB1 VAL B 570 TRP B 596 1 27 HELIX 11 AB2 ASN B 611 ASN B 616 1 6 HELIX 12 AB3 ASN B 618 TRP B 623 1 6 HELIX 13 AB4 THR B 627 SER B 636 1 10 HELIX 14 AB5 ILE B 641 LEU B 663 1 23 HELIX 15 AB6 ARG C 61 GLN C 64 5 4 HELIX 16 AB7 THR C 83 THR C 87 5 5 HELIX 17 AB8 VAL E 100D LYS E 100H 5 5 HELIX 18 AB9 GLU F 79 GLU F 83 5 5 HELIX 19 AC1 ASP G 57 THR G 63 1 7 HELIX 20 AC2 VAL G 101 SER G 115 1 15 HELIX 21 AC3 LEU G 122 CYS G 126 5 5 HELIX 22 AC4 LYS G 335 ARG G 350 1 16 HELIX 23 AC5 LYS G 351 PHE G 353 5 3 HELIX 24 AC6 ASP G 368 THR G 373 1 6 HELIX 25 AC7 MET G 475 ARG G 480 1 6 HELIX 26 AC8 PRO H 61 LYS H 64 5 4 HELIX 27 AC9 THR H 83 THR H 87 5 5 HELIX 28 AD1 THR I 529 SER I 534 1 6 HELIX 29 AD2 LEU I 537 ASN I 543 1 7 HELIX 30 AD3 VAL I 570 TRP I 596 1 27 HELIX 31 AD4 ASN I 611 ASN I 616 1 6 HELIX 32 AD5 ASN I 618 TRP I 623 1 6 HELIX 33 AD6 THR I 627 SER I 636 1 10 HELIX 34 AD7 ILE I 641 LEU I 663 1 23 HELIX 35 AD8 VAL J 100D LYS J 100H 5 5 HELIX 36 AD9 GLU K 79 GLU K 83 5 5 HELIX 37 AE1 GLU L 79 VAL L 83 5 5 HELIX 38 AE2 ARG N 61 GLN N 64 5 4 HELIX 39 AE3 THR N 83 THR N 87 5 5 HELIX 40 AE4 PRO O 61 LYS O 64 5 4 HELIX 41 AE5 THR O 83 THR O 87 5 5 HELIX 42 AE6 GLU P 79 VAL P 83 5 5 HELIX 43 AE7 ASP Q 57 THR Q 63 1 7 HELIX 44 AE8 VAL Q 101 SER Q 115 1 15 HELIX 45 AE9 LEU Q 122 CYS Q 126 5 5 HELIX 46 AF1 LYS Q 335 ARG Q 350 1 16 HELIX 47 AF2 LYS Q 351 PHE Q 353 5 3 HELIX 48 AF3 ASP Q 368 THR Q 373 1 6 HELIX 49 AF4 MET Q 475 ARG Q 480 1 6 HELIX 50 AF5 THR R 529 SER R 534 1 6 HELIX 51 AF6 LEU R 537 ASN R 543 1 7 HELIX 52 AF7 VAL R 570 TRP R 596 1 27 HELIX 53 AF8 ASN R 611 ASN R 616 1 6 HELIX 54 AF9 ASN R 618 TRP R 623 1 6 HELIX 55 AG1 THR R 627 SER R 636 1 10 HELIX 56 AG2 ILE R 641 LEU R 663 1 23 HELIX 57 AG3 VAL S 100D LYS S 100H 5 5 HELIX 58 AG4 GLU T 79 GLU T 83 5 5 HELIX 59 AG5 ARG V 61 GLN V 64 5 4 HELIX 60 AG6 THR V 83 THR V 87 5 5 HELIX 61 AG7 PRO W 61 LYS W 64 5 4 HELIX 62 AG8 THR W 83 THR W 87 5 5 HELIX 63 AG9 GLU X 79 VAL X 83 5 5 SHEET 1 AA1 3 GLY A 495 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 39 -1 N TRP A 35 O THR A 499 SHEET 3 AA1 3 ILE I 603 PRO I 609 -1 O VAL I 608 N VAL A 36 SHEET 1 AA2 5 VAL A 44 ASP A 47 0 SHEET 2 AA2 5 TYR A 486 GLU A 492 -1 O GLU A 492 N VAL A 44 SHEET 3 AA2 5 ALA A 224 CYS A 228 -1 N LEU A 226 O LYS A 487 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O VAL A 245 N ILE A 225 SHEET 5 AA2 5 ILE A 84 HIS A 85 -1 N ILE A 84 O THR A 244 SHEET 1 AA3 2 GLU A 91 ASN A 94 0 SHEET 2 AA3 2 THR A 236 CYS A 239 -1 O GLY A 237 N PHE A 93 SHEET 1 AA4 3 GLN A 130 ASN A 133 0 SHEET 2 AA4 3 LEU A 154 THR A 162 -1 O SER A 158 N GLN A 130 SHEET 3 AA4 3 LYS A 169 TYR A 177 -1 O GLN A 170 N MET A 161 SHEET 1 AA5 2 VAL A 181 GLN A 183 0 SHEET 2 AA5 2 TYR A 191 LEU A 193 -1 O ARG A 192 N VAL A 182 SHEET 1 AA6 6 MET A 271 ARG A 273 0 SHEET 2 AA6 6 ILE A 284 ARG A 298 -1 O GLN A 287 N MET A 271 SHEET 3 AA6 6 HIS A 330 SER A 334 -1 O HIS A 330 N THR A 297 SHEET 4 AA6 6 SER A 413 ILE A 420 -1 O ILE A 414 N VAL A 333 SHEET 5 AA6 6 PHE A 382 CYS A 385 -1 N TYR A 384 O ARG A 419 SHEET 6 AA6 6 HIS A 374 ASN A 377 -1 N HIS A 374 O CYS A 385 SHEET 1 AA7 6 MET A 271 ARG A 273 0 SHEET 2 AA7 6 ILE A 284 ARG A 298 -1 O GLN A 287 N MET A 271 SHEET 3 AA7 6 ILE A 443 THR A 455 -1 O CYS A 445 N CYS A 296 SHEET 4 AA7 6 THR A 465 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 5 AA7 6 ILE A 358 PHE A 361 1 N ARG A 360 O GLU A 466 SHEET 6 AA7 6 SER A 393 TRP A 395 -1 O TRP A 395 N ILE A 359 SHEET 1 AA8 2 ASN A 301 ARG A 308 0 SHEET 2 AA8 2 ALA A 316 ILE A 323 -1 O PHE A 317 N ILE A 307 SHEET 1 AA9 2 ILE A 423 ILE A 424 0 SHEET 2 AA9 2 MET A 434 TYR A 435 -1 O MET A 434 N ILE A 424 SHEET 1 AB1 6 VAL H 11 VAL H 12 0 SHEET 2 AB1 6 VAL H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB1 6 ALA H 88 ASP H 98 -1 N TYR H 90 O VAL H 107 SHEET 4 AB1 6 TYR H 33 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AB1 6 GLU H 46 ALA H 52 -1 O GLU H 46 N ARG H 38 SHEET 6 AB1 6 THR H 57 TYR H 59 -1 O ASP H 58 N GLY H 50 SHEET 1 AB2 4 ARG H 31 PHE H 31B 0 SHEET 2 AB2 4 GLY B 516 PHE B 519 -1 N PHE B 519 O ARG H 31 SHEET 3 AB2 4 ALA H 88 ASP H 98 1 O LYS H 97 N VAL B 518 SHEET 4 AB2 4 SER H 100E TRP H 103 -1 O VAL H 102 N SER H 94 SHEET 1 AB3 3 ILE B 603 PRO B 609 0 SHEET 2 AB3 3 TRP G 35 TYR G 39 -1 O VAL G 36 N VAL B 608 SHEET 3 AB3 3 GLY G 495 THR G 499 -1 O THR G 499 N TRP G 35 SHEET 1 AB4 4 GLN C 3 GLN C 6 0 SHEET 2 AB4 4 VAL C 18 SER C 25 -1 O SER C 25 N GLN C 3 SHEET 3 AB4 4 GLY C 76G PHE C 82 -1 O GLY C 76G N ALA C 24 SHEET 4 AB4 4 MET C 69 GLN C 72 -1 N THR C 70 O TYR C 79 SHEET 1 AB5 6 VAL C 10 ILE C 11 0 SHEET 2 AB5 6 THR C 107 VAL C 110 1 O VAL C 110 N VAL C 10 SHEET 3 AB5 6 ALA C 88 ARG C 95 -1 N ALA C 88 O VAL C 109 SHEET 4 AB5 6 ILE C 34 ILE C 40 -1 N LEU C 39 O GLU C 89 SHEET 5 AB5 6 GLY C 44 ILE C 51 -1 O GLY C 49 N TRP C 36 SHEET 6 AB5 6 VAL C 57 TYR C 59 -1 O SER C 58 N TRP C 50 SHEET 1 AB6 4 VAL C 10 ILE C 11 0 SHEET 2 AB6 4 THR C 107 VAL C 110 1 O VAL C 110 N VAL C 10 SHEET 3 AB6 4 ALA C 88 ARG C 95 -1 N ALA C 88 O VAL C 109 SHEET 4 AB6 4 TRP C 100F TRP C 103 -1 O TYR C 102 N ARG C 94 SHEET 1 AB7 4 THR D 5 GLN D 6 0 SHEET 2 AB7 4 ALA D 19 LYS D 24 -1 O LYS D 24 N THR D 5 SHEET 3 AB7 4 ASP D 69 ILE D 74 -1 O ILE D 74 N ALA D 19 SHEET 4 AB7 4 PHE D 61 SER D 66 -1 N SER D 64 O PHE D 71 SHEET 1 AB8 6 ILE D 10 LEU D 13 0 SHEET 2 AB8 6 SER D 97 VAL D 101 1 O GLU D 100 N LEU D 11 SHEET 3 AB8 6 VAL D 84 GLN D 88 -1 N TYR D 85 O SER D 97 SHEET 4 AB8 6 THR D 33 LYS D 37 -1 N TYR D 35 O TYR D 86 SHEET 5 AB8 6 ARG D 44 TYR D 48 -1 O ILE D 47 N TRP D 34 SHEET 6 AB8 6 ARG D 52 ARG D 53 -1 O ARG D 52 N TYR D 48 SHEET 1 AB9 4 GLN E 5 SER E 7 0 SHEET 2 AB9 4 SER E 19 ASN E 23 -1 O THR E 21 N SER E 7 SHEET 3 AB9 4 LEU E 77 LEU E 82 -1 O LEU E 80 N LEU E 20 SHEET 4 AB9 4 VAL E 67 ASP E 72 -1 N HIS E 68 O ARG E 81 SHEET 1 AC1 5 LEU E 11 VAL E 12 0 SHEET 2 AC1 5 THR E 105 VAL E 109 1 O THR E 108 N VAL E 12 SHEET 3 AC1 5 ALA E 88 LYS E 96 -1 N ALA E 88 O VAL E 107 SHEET 4 AC1 5 TYR E 33 GLN E 39 -1 N GLN E 39 O ILE E 89 SHEET 5 AC1 5 GLU E 46 VAL E 51 -1 O ILE E 48 N TRP E 36 SHEET 1 AC2 4 LEU E 11 VAL E 12 0 SHEET 2 AC2 4 THR E 105 VAL E 109 1 O THR E 108 N VAL E 12 SHEET 3 AC2 4 ALA E 88 LYS E 96 -1 N ALA E 88 O VAL E 107 SHEET 4 AC2 4 TYR E 100O MET E 100P-1 O TYR E 100O N LYS E 96 SHEET 1 AC3 2 ARG E 99 ILE E 100A 0 SHEET 2 AC3 2 TRP E 100J THR E 100L-1 O PHE E 100K N ARG E 100 SHEET 1 AC4 5 VAL F 11 VAL F 13 0 SHEET 2 AC4 5 THR F 102 VAL F 106 1 O ILE F 105 N VAL F 11 SHEET 3 AC4 5 ALA F 84 HIS F 89 -1 N ALA F 84 O LEU F 104 SHEET 4 AC4 5 ILE F 34 GLN F 38 -1 N TYR F 36 O TYR F 87 SHEET 5 AC4 5 PRO F 44 ILE F 48 -1 O SER F 45 N GLN F 37 SHEET 1 AC5 3 ALA F 19 CYS F 23 0 SHEET 2 AC5 3 ALA F 71 ILE F 75 -1 O ILE F 75 N ALA F 19 SHEET 3 AC5 3 PHE F 62 GLY F 64 -1 N SER F 63 O THR F 74 SHEET 1 AC6 5 VAL G 44 ASP G 47 0 SHEET 2 AC6 5 TYR G 486 GLU G 492 -1 O GLU G 492 N VAL G 44 SHEET 3 AC6 5 ALA G 224 CYS G 228 -1 N LEU G 226 O LYS G 487 SHEET 4 AC6 5 VAL G 242 VAL G 245 -1 O VAL G 245 N ILE G 225 SHEET 5 AC6 5 ILE G 84 HIS G 85 -1 N ILE G 84 O THR G 244 SHEET 1 AC7 2 GLU G 91 ASN G 94 0 SHEET 2 AC7 2 THR G 236 CYS G 239 -1 O GLY G 237 N PHE G 93 SHEET 1 AC8 3 GLN G 130 ASN G 133 0 SHEET 2 AC8 3 LEU G 154 THR G 162 -1 O SER G 158 N GLN G 130 SHEET 3 AC8 3 LYS G 169 TYR G 177 -1 O GLN G 170 N MET G 161 SHEET 1 AC9 2 VAL G 181 GLN G 183 0 SHEET 2 AC9 2 TYR G 191 LEU G 193 -1 O ARG G 192 N VAL G 182 SHEET 1 AD1 6 MET G 271 ARG G 273 0 SHEET 2 AD1 6 ILE G 284 ARG G 298 -1 O GLN G 287 N MET G 271 SHEET 3 AD1 6 HIS G 330 SER G 334 -1 O HIS G 330 N THR G 297 SHEET 4 AD1 6 SER G 413 ILE G 420 -1 O ILE G 414 N VAL G 333 SHEET 5 AD1 6 PHE G 382 CYS G 385 -1 N TYR G 384 O ARG G 419 SHEET 6 AD1 6 HIS G 374 ASN G 377 -1 N HIS G 374 O CYS G 385 SHEET 1 AD2 6 MET G 271 ARG G 273 0 SHEET 2 AD2 6 ILE G 284 ARG G 298 -1 O GLN G 287 N MET G 271 SHEET 3 AD2 6 ILE G 443 THR G 455 -1 O CYS G 445 N CYS G 296 SHEET 4 AD2 6 THR G 465 PRO G 470 -1 O ARG G 469 N THR G 455 SHEET 5 AD2 6 ILE G 358 PHE G 361 1 N ARG G 360 O GLU G 466 SHEET 6 AD2 6 SER G 393 TRP G 395 -1 O TRP G 395 N ILE G 359 SHEET 1 AD3 2 ASN G 301 ARG G 308 0 SHEET 2 AD3 2 ALA G 316 ILE G 323 -1 O PHE G 317 N ILE G 307 SHEET 1 AD4 2 ILE G 423 ILE G 424 0 SHEET 2 AD4 2 MET G 434 TYR G 435 -1 O MET G 434 N ILE G 424 SHEET 1 AD5 4 GLN H 3 SER H 7 0 SHEET 2 AD5 4 LEU H 18 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AD5 4 GLN H 77 LEU H 82 -1 O LEU H 82 N LEU H 18 SHEET 4 AD5 4 ALA H 67 ASP H 72 -1 N ASP H 72 O GLN H 77 SHEET 1 AD6 6 VAL O 11 VAL O 12 0 SHEET 2 AD6 6 VAL O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AD6 6 ALA O 88 ASP O 98 -1 N TYR O 90 O VAL O 107 SHEET 4 AD6 6 TYR O 33 GLN O 39 -1 N VAL O 37 O TYR O 91 SHEET 5 AD6 6 GLU O 46 ALA O 52 -1 O GLU O 46 N ARG O 38 SHEET 6 AD6 6 THR O 57 TYR O 59 -1 O ASP O 58 N GLY O 50 SHEET 1 AD7 4 GLY O 30 PHE O 31B 0 SHEET 2 AD7 4 GLY I 516 LEU I 520 -1 N ALA I 517 O PHE O 31B SHEET 3 AD7 4 ALA O 88 ASP O 98 1 O LYS O 97 N VAL I 518 SHEET 4 AD7 4 SER O 100E TRP O 103 -1 O VAL O 102 N SER O 94 SHEET 1 AD8 4 GLN J 5 SER J 7 0 SHEET 2 AD8 4 SER J 19 ASN J 23 -1 O THR J 21 N SER J 7 SHEET 3 AD8 4 LEU J 77 LEU J 82 -1 O LEU J 80 N LEU J 20 SHEET 4 AD8 4 VAL J 67 ASP J 72 -1 N HIS J 68 O ARG J 81 SHEET 1 AD9 5 LEU J 11 VAL J 12 0 SHEET 2 AD9 5 THR J 105 VAL J 109 1 O THR J 108 N VAL J 12 SHEET 3 AD9 5 ALA J 88 LYS J 96 -1 N ALA J 88 O VAL J 107 SHEET 4 AD9 5 TYR J 33 GLN J 39 -1 N GLN J 39 O ILE J 89 SHEET 5 AD9 5 GLU J 46 VAL J 51 -1 O ILE J 48 N TRP J 36 SHEET 1 AE1 4 LEU J 11 VAL J 12 0 SHEET 2 AE1 4 THR J 105 VAL J 109 1 O THR J 108 N VAL J 12 SHEET 3 AE1 4 ALA J 88 LYS J 96 -1 N ALA J 88 O VAL J 107 SHEET 4 AE1 4 TYR J 100O MET J 100P-1 O TYR J 100O N LYS J 96 SHEET 1 AE2 2 ARG J 99 ILE J 100A 0 SHEET 2 AE2 2 TRP J 100J THR J 100L-1 O PHE J 100K N ARG J 100 SHEET 1 AE3 5 VAL K 11 VAL K 13 0 SHEET 2 AE3 5 THR K 102 VAL K 106 1 O ILE K 105 N VAL K 11 SHEET 3 AE3 5 ALA K 84 HIS K 89 -1 N ALA K 84 O LEU K 104 SHEET 4 AE3 5 ILE K 34 GLN K 38 -1 N TYR K 36 O TYR K 87 SHEET 5 AE3 5 PRO K 44 ILE K 48 -1 O SER K 45 N GLN K 37 SHEET 1 AE4 3 ALA K 19 CYS K 23 0 SHEET 2 AE4 3 ALA K 71 ILE K 75 -1 O ILE K 75 N ALA K 19 SHEET 3 AE4 3 PHE K 62 GLY K 64 -1 N SER K 63 O THR K 74 SHEET 1 AE5 4 MET L 4 THR L 7 0 SHEET 2 AE5 4 ALA L 19 SER L 25 -1 O SER L 22 N THR L 7 SHEET 3 AE5 4 ASP L 70 ILE L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AE5 4 PHE L 62 GLY L 66 -1 N SER L 63 O LYS L 74 SHEET 1 AE6 4 PRO L 44 ILE L 48 0 SHEET 2 AE6 4 LEU L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 3 AE6 4 GLY L 84 GLN L 90 -1 O TYR L 87 N PHE L 36 SHEET 4 AE6 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AE7 4 PRO L 44 ILE L 48 0 SHEET 2 AE7 4 LEU L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 3 AE7 4 GLY L 84 GLN L 90 -1 O TYR L 87 N PHE L 36 SHEET 4 AE7 4 THR L 102 VAL L 104 -1 O VAL L 104 N GLY L 84 SHEET 1 AE8 4 THR M 5 GLN M 6 0 SHEET 2 AE8 4 ALA M 19 LYS M 24 -1 O LYS M 24 N THR M 5 SHEET 3 AE8 4 ASP M 69 ILE M 74 -1 O ILE M 74 N ALA M 19 SHEET 4 AE8 4 PHE M 61 SER M 66 -1 N SER M 64 O PHE M 71 SHEET 1 AE9 6 ILE M 10 LEU M 13 0 SHEET 2 AE9 6 SER M 97 VAL M 101 1 O GLU M 100 N LEU M 11 SHEET 3 AE9 6 VAL M 84 GLN M 88 -1 N TYR M 85 O SER M 97 SHEET 4 AE9 6 THR M 33 LYS M 37 -1 N TYR M 35 O TYR M 86 SHEET 5 AE9 6 ARG M 44 TYR M 48 -1 O ILE M 47 N TRP M 34 SHEET 6 AE9 6 ARG M 52 ARG M 53 -1 O ARG M 52 N TYR M 48 SHEET 1 AF1 4 GLN N 3 GLN N 6 0 SHEET 2 AF1 4 VAL N 18 SER N 25 -1 O SER N 25 N GLN N 3 SHEET 3 AF1 4 GLY N 76G PHE N 82 -1 O GLY N 76G N ALA N 24 SHEET 4 AF1 4 MET N 69 GLN N 72 -1 N THR N 70 O TYR N 79 SHEET 1 AF2 6 VAL N 10 ILE N 11 0 SHEET 2 AF2 6 THR N 107 VAL N 110 1 O VAL N 110 N VAL N 10 SHEET 3 AF2 6 ALA N 88 ARG N 95 -1 N ALA N 88 O VAL N 109 SHEET 4 AF2 6 ILE N 34 ILE N 40 -1 N LEU N 39 O GLU N 89 SHEET 5 AF2 6 GLY N 44 ILE N 51 -1 O GLY N 49 N TRP N 36 SHEET 6 AF2 6 VAL N 57 TYR N 59 -1 O SER N 58 N TRP N 50 SHEET 1 AF3 4 VAL N 10 ILE N 11 0 SHEET 2 AF3 4 THR N 107 VAL N 110 1 O VAL N 110 N VAL N 10 SHEET 3 AF3 4 ALA N 88 ARG N 95 -1 N ALA N 88 O VAL N 109 SHEET 4 AF3 4 TRP N 100F TRP N 103 -1 O TYR N 102 N ARG N 94 SHEET 1 AF4 4 GLN O 3 SER O 7 0 SHEET 2 AF4 4 LEU O 18 SER O 25 -1 O SER O 25 N GLN O 3 SHEET 3 AF4 4 GLN O 77 LEU O 82 -1 O LEU O 82 N LEU O 18 SHEET 4 AF4 4 ALA O 67 ASP O 72 -1 N ASP O 72 O GLN O 77 SHEET 1 AF5 4 MET P 4 THR P 7 0 SHEET 2 AF5 4 ALA P 19 SER P 25 -1 O SER P 22 N THR P 7 SHEET 3 AF5 4 ASP P 70 ILE P 75 -1 O PHE P 71 N CYS P 23 SHEET 4 AF5 4 PHE P 62 GLY P 66 -1 N SER P 63 O LYS P 74 SHEET 1 AF6 4 PRO P 44 ILE P 48 0 SHEET 2 AF6 4 LEU P 33 GLN P 38 -1 N TRP P 35 O ILE P 48 SHEET 3 AF6 4 GLY P 84 GLN P 90 -1 O TYR P 87 N PHE P 36 SHEET 4 AF6 4 THR P 97 PHE P 98 -1 O THR P 97 N GLN P 90 SHEET 1 AF7 4 PRO P 44 ILE P 48 0 SHEET 2 AF7 4 LEU P 33 GLN P 38 -1 N TRP P 35 O ILE P 48 SHEET 3 AF7 4 GLY P 84 GLN P 90 -1 O TYR P 87 N PHE P 36 SHEET 4 AF7 4 THR P 102 VAL P 104 -1 O VAL P 104 N GLY P 84 SHEET 1 AF8 3 GLY Q 495 THR Q 499 0 SHEET 2 AF8 3 TRP Q 35 TYR Q 39 -1 N TRP Q 35 O THR Q 499 SHEET 3 AF8 3 ILE R 603 PRO R 609 -1 O VAL R 608 N VAL Q 36 SHEET 1 AF9 5 VAL Q 44 ASP Q 47 0 SHEET 2 AF9 5 TYR Q 486 GLU Q 492 -1 O GLU Q 492 N VAL Q 44 SHEET 3 AF9 5 ALA Q 224 CYS Q 228 -1 N LEU Q 226 O LYS Q 487 SHEET 4 AF9 5 VAL Q 242 VAL Q 245 -1 O VAL Q 245 N ILE Q 225 SHEET 5 AF9 5 ILE Q 84 HIS Q 85 -1 N ILE Q 84 O THR Q 244 SHEET 1 AG1 2 GLU Q 91 ASN Q 94 0 SHEET 2 AG1 2 THR Q 236 CYS Q 239 -1 O GLY Q 237 N PHE Q 93 SHEET 1 AG2 3 GLN Q 130 ASN Q 133 0 SHEET 2 AG2 3 LEU Q 154 THR Q 162 -1 O SER Q 158 N GLN Q 130 SHEET 3 AG2 3 LYS Q 169 TYR Q 177 -1 O GLN Q 170 N MET Q 161 SHEET 1 AG3 2 VAL Q 181 GLN Q 183 0 SHEET 2 AG3 2 TYR Q 191 LEU Q 193 -1 O ARG Q 192 N VAL Q 182 SHEET 1 AG4 6 MET Q 271 ARG Q 273 0 SHEET 2 AG4 6 ILE Q 284 ARG Q 298 -1 O GLN Q 287 N MET Q 271 SHEET 3 AG4 6 HIS Q 330 SER Q 334 -1 O HIS Q 330 N THR Q 297 SHEET 4 AG4 6 SER Q 413 ILE Q 420 -1 O ILE Q 414 N VAL Q 333 SHEET 5 AG4 6 PHE Q 382 CYS Q 385 -1 N TYR Q 384 O ARG Q 419 SHEET 6 AG4 6 HIS Q 374 ASN Q 377 -1 N HIS Q 374 O CYS Q 385 SHEET 1 AG5 6 MET Q 271 ARG Q 273 0 SHEET 2 AG5 6 ILE Q 284 ARG Q 298 -1 O GLN Q 287 N MET Q 271 SHEET 3 AG5 6 ILE Q 443 THR Q 455 -1 O CYS Q 445 N CYS Q 296 SHEET 4 AG5 6 THR Q 465 PRO Q 470 -1 O ARG Q 469 N THR Q 455 SHEET 5 AG5 6 ILE Q 358 PHE Q 361 1 N ARG Q 360 O GLU Q 466 SHEET 6 AG5 6 SER Q 393 TRP Q 395 -1 O TRP Q 395 N ILE Q 359 SHEET 1 AG6 2 ASN Q 301 ARG Q 308 0 SHEET 2 AG6 2 ALA Q 316 ILE Q 323 -1 O PHE Q 317 N ILE Q 307 SHEET 1 AG7 2 ILE Q 423 ILE Q 424 0 SHEET 2 AG7 2 MET Q 434 TYR Q 435 -1 O MET Q 434 N ILE Q 424 SHEET 1 AG8 6 VAL W 11 VAL W 12 0 SHEET 2 AG8 6 VAL W 107 VAL W 111 1 O THR W 110 N VAL W 12 SHEET 3 AG8 6 ALA W 88 ASP W 98 -1 N TYR W 90 O VAL W 107 SHEET 4 AG8 6 TYR W 33 GLN W 39 -1 N VAL W 37 O TYR W 91 SHEET 5 AG8 6 GLU W 46 ALA W 52 -1 O GLU W 46 N ARG W 38 SHEET 6 AG8 6 THR W 57 TYR W 59 -1 O ASP W 58 N GLY W 50 SHEET 1 AG9 4 GLY W 30 PHE W 31B 0 SHEET 2 AG9 4 GLY R 516 LEU R 520 -1 N ALA R 517 O PHE W 31B SHEET 3 AG9 4 ALA W 88 ASP W 98 1 O LYS W 97 N GLY R 516 SHEET 4 AG9 4 SER W 100E TRP W 103 -1 O VAL W 102 N SER W 94 SHEET 1 AH1 4 GLN S 5 SER S 7 0 SHEET 2 AH1 4 SER S 19 ASN S 23 -1 O THR S 21 N SER S 7 SHEET 3 AH1 4 LEU S 77 LEU S 82 -1 O LEU S 80 N LEU S 20 SHEET 4 AH1 4 VAL S 67 ASP S 72 -1 N HIS S 68 O ARG S 81 SHEET 1 AH2 5 LEU S 11 VAL S 12 0 SHEET 2 AH2 5 THR S 105 VAL S 109 1 O THR S 108 N VAL S 12 SHEET 3 AH2 5 ALA S 88 LYS S 96 -1 N ALA S 88 O VAL S 107 SHEET 4 AH2 5 TYR S 33 GLN S 39 -1 N GLN S 39 O ILE S 89 SHEET 5 AH2 5 GLU S 46 VAL S 51 -1 O ILE S 48 N TRP S 36 SHEET 1 AH3 4 LEU S 11 VAL S 12 0 SHEET 2 AH3 4 THR S 105 VAL S 109 1 O THR S 108 N VAL S 12 SHEET 3 AH3 4 ALA S 88 LYS S 96 -1 N ALA S 88 O VAL S 107 SHEET 4 AH3 4 TYR S 100O MET S 100P-1 O TYR S 100O N LYS S 96 SHEET 1 AH4 2 ARG S 99 ILE S 100A 0 SHEET 2 AH4 2 TRP S 100J THR S 100L-1 O PHE S 100K N ARG S 100 SHEET 1 AH5 5 VAL T 11 VAL T 13 0 SHEET 2 AH5 5 THR T 102 VAL T 106 1 O ILE T 105 N VAL T 11 SHEET 3 AH5 5 ALA T 84 HIS T 89 -1 N ALA T 84 O LEU T 104 SHEET 4 AH5 5 ILE T 34 GLN T 38 -1 N TYR T 36 O TYR T 87 SHEET 5 AH5 5 PRO T 44 ILE T 48 -1 O SER T 45 N GLN T 37 SHEET 1 AH6 3 ALA T 19 CYS T 23 0 SHEET 2 AH6 3 ALA T 71 ILE T 75 -1 O ILE T 75 N ALA T 19 SHEET 3 AH6 3 PHE T 62 GLY T 64 -1 N SER T 63 O THR T 74 SHEET 1 AH7 4 THR U 5 GLN U 6 0 SHEET 2 AH7 4 ALA U 19 LYS U 24 -1 O LYS U 24 N THR U 5 SHEET 3 AH7 4 ASP U 69 ILE U 74 -1 O ILE U 74 N ALA U 19 SHEET 4 AH7 4 PHE U 61 SER U 66 -1 N SER U 64 O PHE U 71 SHEET 1 AH8 6 ILE U 10 LEU U 13 0 SHEET 2 AH8 6 SER U 97 VAL U 101 1 O GLU U 100 N LEU U 11 SHEET 3 AH8 6 VAL U 84 GLN U 88 -1 N TYR U 85 O SER U 97 SHEET 4 AH8 6 THR U 33 LYS U 37 -1 N TYR U 35 O TYR U 86 SHEET 5 AH8 6 ARG U 44 TYR U 48 -1 O ILE U 47 N TRP U 34 SHEET 6 AH8 6 ARG U 52 ARG U 53 -1 O ARG U 52 N TYR U 48 SHEET 1 AH9 4 GLN V 3 GLN V 6 0 SHEET 2 AH9 4 VAL V 18 SER V 25 -1 O SER V 25 N GLN V 3 SHEET 3 AH9 4 GLY V 76G PHE V 82 -1 O GLY V 76G N ALA V 24 SHEET 4 AH9 4 MET V 69 GLN V 72 -1 N THR V 70 O TYR V 79 SHEET 1 AI1 6 VAL V 10 ILE V 11 0 SHEET 2 AI1 6 THR V 107 VAL V 110 1 O VAL V 110 N VAL V 10 SHEET 3 AI1 6 ALA V 88 ARG V 95 -1 N ALA V 88 O VAL V 109 SHEET 4 AI1 6 ILE V 34 ILE V 40 -1 N LEU V 39 O GLU V 89 SHEET 5 AI1 6 GLY V 44 ILE V 51 -1 O GLY V 49 N TRP V 36 SHEET 6 AI1 6 VAL V 57 TYR V 59 -1 O SER V 58 N TRP V 50 SHEET 1 AI2 4 VAL V 10 ILE V 11 0 SHEET 2 AI2 4 THR V 107 VAL V 110 1 O VAL V 110 N VAL V 10 SHEET 3 AI2 4 ALA V 88 ARG V 95 -1 N ALA V 88 O VAL V 109 SHEET 4 AI2 4 TRP V 100F TRP V 103 -1 O TYR V 102 N ARG V 94 SHEET 1 AI3 4 GLN W 3 SER W 7 0 SHEET 2 AI3 4 LEU W 18 SER W 25 -1 O SER W 25 N GLN W 3 SHEET 3 AI3 4 GLN W 77 LEU W 82 -1 O LEU W 82 N LEU W 18 SHEET 4 AI3 4 ALA W 67 ASP W 72 -1 N ASP W 72 O GLN W 77 SHEET 1 AI4 4 MET X 4 THR X 7 0 SHEET 2 AI4 4 ALA X 19 SER X 25 -1 O SER X 22 N THR X 7 SHEET 3 AI4 4 ASP X 70 ILE X 75 -1 O PHE X 71 N CYS X 23 SHEET 4 AI4 4 PHE X 62 GLY X 66 -1 N SER X 63 O LYS X 74 SHEET 1 AI5 4 PRO X 44 ILE X 48 0 SHEET 2 AI5 4 LEU X 33 GLN X 38 -1 N TRP X 35 O ILE X 48 SHEET 3 AI5 4 GLY X 84 GLN X 90 -1 O TYR X 87 N PHE X 36 SHEET 4 AI5 4 THR X 97 PHE X 98 -1 O THR X 97 N GLN X 90 SHEET 1 AI6 4 PRO X 44 ILE X 48 0 SHEET 2 AI6 4 LEU X 33 GLN X 38 -1 N TRP X 35 O ILE X 48 SHEET 3 AI6 4 GLY X 84 GLN X 90 -1 O TYR X 87 N PHE X 36 SHEET 4 AI6 4 THR X 102 VAL X 104 -1 O VAL X 104 N GLY X 84 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.05 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.04 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 5 CYS A 201 CYS A 433 1555 1555 2.04 SSBOND 6 CYS A 218 CYS A 247 1555 1555 2.02 SSBOND 7 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 8 CYS A 296 CYS A 331 1555 1555 2.03 SSBOND 9 CYS A 378 CYS A 445 1555 1555 2.03 SSBOND 10 CYS A 385 CYS A 418 1555 1555 2.03 SSBOND 11 CYS B 598 CYS B 604 1555 1555 2.02 SSBOND 12 CYS C 22 CYS C 92 1555 1555 2.03 SSBOND 13 CYS C 98 CYS C 100A 1555 1555 2.03 SSBOND 14 CYS E 22 CYS E 92 1555 1555 2.04 SSBOND 15 CYS F 23 CYS F 88 1555 1555 2.04 SSBOND 16 CYS G 54 CYS G 74 1555 1555 2.05 SSBOND 17 CYS G 119 CYS G 205 1555 1555 2.04 SSBOND 18 CYS G 126 CYS G 196 1555 1555 2.03 SSBOND 19 CYS G 131 CYS G 157 1555 1555 2.03 SSBOND 20 CYS G 201 CYS G 433 1555 1555 2.04 SSBOND 21 CYS G 218 CYS G 247 1555 1555 2.03 SSBOND 22 CYS G 228 CYS G 239 1555 1555 2.03 SSBOND 23 CYS G 296 CYS G 331 1555 1555 2.03 SSBOND 24 CYS G 378 CYS G 445 1555 1555 2.03 SSBOND 25 CYS G 385 CYS G 418 1555 1555 2.03 SSBOND 26 CYS H 22 CYS H 92 1555 1555 2.04 SSBOND 27 CYS I 598 CYS I 604 1555 1555 2.02 SSBOND 28 CYS J 22 CYS J 92 1555 1555 2.04 SSBOND 29 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 30 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 31 CYS N 22 CYS N 92 1555 1555 2.03 SSBOND 32 CYS N 98 CYS N 100A 1555 1555 2.03 SSBOND 33 CYS O 22 CYS O 92 1555 1555 2.04 SSBOND 34 CYS P 23 CYS P 88 1555 1555 2.04 SSBOND 35 CYS Q 54 CYS Q 74 1555 1555 2.04 SSBOND 36 CYS Q 119 CYS Q 205 1555 1555 2.04 SSBOND 37 CYS Q 126 CYS Q 196 1555 1555 2.03 SSBOND 38 CYS Q 131 CYS Q 157 1555 1555 2.03 SSBOND 39 CYS Q 201 CYS Q 433 1555 1555 2.04 SSBOND 40 CYS Q 218 CYS Q 247 1555 1555 2.03 SSBOND 41 CYS Q 228 CYS Q 239 1555 1555 2.03 SSBOND 42 CYS Q 296 CYS Q 331 1555 1555 2.03 SSBOND 43 CYS Q 378 CYS Q 445 1555 1555 2.03 SSBOND 44 CYS Q 385 CYS Q 418 1555 1555 2.03 SSBOND 45 CYS R 598 CYS R 604 1555 1555 2.02 SSBOND 46 CYS S 22 CYS S 92 1555 1555 2.04 SSBOND 47 CYS T 23 CYS T 88 1555 1555 2.04 SSBOND 48 CYS V 22 CYS V 92 1555 1555 2.03 SSBOND 49 CYS V 98 CYS V 100A 1555 1555 2.03 SSBOND 50 CYS W 22 CYS W 92 1555 1555 2.04 SSBOND 51 CYS X 23 CYS X 88 1555 1555 2.04 LINK ND2 ASN A 88 C1 NAG A 601 1555 1555 1.46 LINK ND2 ASN A 133 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 137 C1 NAG A 605 1555 1555 1.43 LINK ND2 ASN A 156 C1 NAG A 609 1555 1555 1.42 LINK ND2 ASN A 160 C1 NAG A 614 1555 1555 1.45 LINK ND2 ASN A 197 C1 NAG A 617 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 621 1555 1555 1.43 LINK ND2 ASN A 262 C1 NAG A 624 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG A 657 1555 1555 1.43 LINK ND2 ASN A 295 C1 NAG A 630 1555 1555 1.42 LINK ND2 ASN A 301 C1 NAG A 632 1555 1555 1.45 LINK ND2 ASN A 332 C1 NAG A 645 1555 1555 1.43 LINK ND2 ASN A 355 C1 NAG A 634 1555 1555 1.45 LINK ND2 ASN A 363 C1 NAG A 635 1555 1555 1.44 LINK ND2 ASN A 386 C1 NAG A 638 1555 1555 1.43 LINK ND2 ASN A 392 C1 NAG A 643 1555 1555 1.40 LINK ND2 ASN A 448 C1 NAG A 654 1555 1555 1.43 LINK ND2 ASN B 611 C1 NAG B 702 1555 1555 1.43 LINK ND2 ASN B 637 C1 NAG B 701 1555 1555 1.44 LINK ND2 ASN G 88 C1 NAG G 601 1555 1555 1.46 LINK ND2 ASN G 133 C1 NAG G 603 1555 1555 1.44 LINK ND2 ASN G 137 C1 NAG G 605 1555 1555 1.44 LINK ND2 ASN G 156 C1 NAG G 609 1555 1555 1.42 LINK ND2 ASN G 160 C1 NAG G 614 1555 1555 1.45 LINK ND2 ASN G 197 C1 NAG G 617 1555 1555 1.44 LINK ND2 ASN G 234 C1 NAG G 621 1555 1555 1.43 LINK ND2 ASN G 262 C1 NAG G 624 1555 1555 1.44 LINK ND2 ASN G 276 C1 NAG G 657 1555 1555 1.43 LINK ND2 ASN G 295 C1 NAG G 630 1555 1555 1.42 LINK ND2 ASN G 301 C1 NAG G 632 1555 1555 1.45 LINK ND2 ASN G 332 C1 NAG G 645 1555 1555 1.43 LINK ND2 ASN G 355 C1 NAG G 634 1555 1555 1.45 LINK ND2 ASN G 363 C1 NAG G 635 1555 1555 1.44 LINK ND2 ASN G 386 C1 NAG G 638 1555 1555 1.43 LINK ND2 ASN G 392 C1 NAG G 643 1555 1555 1.40 LINK ND2 ASN G 448 C1 NAG G 654 1555 1555 1.43 LINK ND2 ASN I 611 C1 NAG I 702 1555 1555 1.43 LINK ND2 ASN I 637 C1 NAG I 701 1555 1555 1.44 LINK ND2 ASN Q 88 C1 NAG Q 601 1555 1555 1.47 LINK ND2 ASN Q 133 C1 NAG Q 603 1555 1555 1.44 LINK ND2 ASN Q 137 C1 NAG Q 605 1555 1555 1.44 LINK ND2 ASN Q 156 C1 NAG Q 609 1555 1555 1.42 LINK ND2 ASN Q 160 C1 NAG Q 614 1555 1555 1.45 LINK ND2 ASN Q 197 C1 NAG Q 617 1555 1555 1.44 LINK ND2 ASN Q 234 C1 NAG Q 621 1555 1555 1.43 LINK ND2 ASN Q 262 C1 NAG Q 624 1555 1555 1.44 LINK ND2 ASN Q 276 C1 NAG Q 657 1555 1555 1.43 LINK ND2 ASN Q 295 C1 NAG Q 630 1555 1555 1.42 LINK ND2 ASN Q 301 C1 NAG Q 632 1555 1555 1.45 LINK ND2 ASN Q 332 C1 NAG Q 645 1555 1555 1.43 LINK ND2 ASN Q 355 C1 NAG Q 634 1555 1555 1.45 LINK ND2 ASN Q 363 C1 NAG Q 635 1555 1555 1.44 LINK ND2 ASN Q 386 C1 NAG Q 638 1555 1555 1.43 LINK ND2 ASN Q 392 C1 NAG Q 643 1555 1555 1.40 LINK ND2 ASN Q 448 C1 NAG Q 654 1555 1555 1.43 LINK ND2 ASN R 611 C1 NAG R 702 1555 1555 1.43 LINK ND2 ASN R 637 C1 NAG R 701 1555 1555 1.44 LINK O4 NAG A 601 C1 NAG A 602 1555 1555 1.44 LINK O4 NAG A 603 C1 NAG A 604 1555 1555 1.44 LINK O4 NAG A 605 C1 NAG A 606 1555 1555 1.43 LINK O4 NAG A 606 C1 BMA A 607 1555 1555 1.44 LINK O3 BMA A 607 C1 MAN A 608 1555 1555 1.46 LINK O4 NAG A 609 C1 NAG A 610 1555 1555 1.44 LINK O4 NAG A 610 C1 BMA A 611 1555 1555 1.44 LINK O3 BMA A 611 C1 MAN A 612 1555 1555 1.45 LINK O6 BMA A 611 C1 MAN A 613 1555 1555 1.45 LINK O4 NAG A 614 C1 NAG A 615 1555 1555 1.43 LINK O4 NAG A 615 C1 BMA A 616 1555 1555 1.45 LINK O4 NAG A 617 C1 NAG A 618 1555 1555 1.44 LINK O4 NAG A 618 C1 BMA A 619 1555 1555 1.45 LINK O6 BMA A 619 C1 MAN A 620 1555 1555 1.44 LINK O4 NAG A 621 C1 NAG A 622 1555 1555 1.45 LINK O4 NAG A 622 C1 BMA A 623 1555 1555 1.44 LINK O4 NAG A 624 C1 NAG A 625 1555 1555 1.45 LINK O4 NAG A 625 C1 BMA A 626 1555 1555 1.44 LINK O3 BMA A 626 C1 MAN A 627 1555 1555 1.44 LINK O6 BMA A 626 C1 MAN A 628 1555 1555 1.44 LINK O2 MAN A 627 C1 MAN A 629 1555 1555 1.44 LINK O4 NAG A 630 C1 NAG A 631 1555 1555 1.44 LINK O4 NAG A 632 C1 NAG A 633 1555 1555 1.45 LINK O4 NAG A 635 C1 NAG A 636 1555 1555 1.44 LINK O4 NAG A 636 C1 BMA A 637 1555 1555 1.45 LINK O4 NAG A 638 C1 NAG A 639 1555 1555 1.44 LINK O4 NAG A 639 C1 BMA A 640 1555 1555 1.45 LINK O3 BMA A 640 C1 MAN A 641 1555 1555 1.44 LINK O6 BMA A 640 C1 MAN A 642 1555 1555 1.44 LINK O4 NAG A 643 C1 NAG A 644 1555 1555 1.47 LINK O4 NAG A 645 C1 NAG A 646 1555 1555 1.43 LINK O4 NAG A 646 C1 BMA A 647 1555 1555 1.44 LINK O3 BMA A 647 C1 MAN A 648 1555 1555 1.44 LINK O6 BMA A 647 C1 MAN A 649 1555 1555 1.44 LINK O2 MAN A 648 C1 MAN A 650 1555 1555 1.44 LINK O3 MAN A 649 C1 MAN A 651 1555 1555 1.44 LINK O6 MAN A 649 C1 MAN A 652 1555 1555 1.45 LINK O2 MAN A 650 C1 MAN A 653 1555 1555 1.44 LINK O4 NAG A 654 C1 NAG A 655 1555 1555 1.45 LINK O4 NAG A 655 C1 BMA A 656 1555 1555 1.44 LINK O4 NAG A 657 C1 NAG A 658 1555 1555 1.44 LINK O4 NAG A 658 C1 BMA A 659 1555 1555 1.44 LINK O3 BMA A 659 C1 MAN A 660 1555 1555 1.45 LINK O4 NAG G 601 C1 NAG G 602 1555 1555 1.44 LINK O4 NAG G 603 C1 NAG G 604 1555 1555 1.45 LINK O4 NAG G 605 C1 NAG G 606 1555 1555 1.43 LINK O4 NAG G 606 C1 BMA G 607 1555 1555 1.44 LINK O3 BMA G 607 C1 MAN G 608 1555 1555 1.46 LINK O4 NAG G 609 C1 NAG G 610 1555 1555 1.44 LINK O4 NAG G 610 C1 BMA G 611 1555 1555 1.44 LINK O3 BMA G 611 C1 MAN G 612 1555 1555 1.44 LINK O6 BMA G 611 C1 MAN G 613 1555 1555 1.45 LINK O4 NAG G 614 C1 NAG G 615 1555 1555 1.43 LINK O4 NAG G 615 C1 BMA G 616 1555 1555 1.45 LINK O4 NAG G 617 C1 NAG G 618 1555 1555 1.44 LINK O4 NAG G 618 C1 BMA G 619 1555 1555 1.45 LINK O6 BMA G 619 C1 MAN G 620 1555 1555 1.44 LINK O4 NAG G 621 C1 NAG G 622 1555 1555 1.45 LINK O4 NAG G 622 C1 BMA G 623 1555 1555 1.44 LINK O4 NAG G 624 C1 NAG G 625 1555 1555 1.45 LINK O4 NAG G 625 C1 BMA G 626 1555 1555 1.44 LINK O3 BMA G 626 C1 MAN G 627 1555 1555 1.44 LINK O6 BMA G 626 C1 MAN G 628 1555 1555 1.43 LINK O2 MAN G 627 C1 MAN G 629 1555 1555 1.44 LINK O4 NAG G 630 C1 NAG G 631 1555 1555 1.44 LINK O4 NAG G 632 C1 NAG G 633 1555 1555 1.45 LINK O4 NAG G 635 C1 NAG G 636 1555 1555 1.44 LINK O4 NAG G 636 C1 BMA G 637 1555 1555 1.45 LINK O4 NAG G 638 C1 NAG G 639 1555 1555 1.44 LINK O4 NAG G 639 C1 BMA G 640 1555 1555 1.45 LINK O3 BMA G 640 C1 MAN G 641 1555 1555 1.44 LINK O6 BMA G 640 C1 MAN G 642 1555 1555 1.44 LINK O4 NAG G 643 C1 NAG G 644 1555 1555 1.47 LINK O4 NAG G 645 C1 NAG G 646 1555 1555 1.43 LINK O4 NAG G 646 C1 BMA G 647 1555 1555 1.44 LINK O3 BMA G 647 C1 MAN G 648 1555 1555 1.44 LINK O6 BMA G 647 C1 MAN G 649 1555 1555 1.44 LINK O2 MAN G 648 C1 MAN G 650 1555 1555 1.44 LINK O3 MAN G 649 C1 MAN G 651 1555 1555 1.44 LINK O6 MAN G 649 C1 MAN G 652 1555 1555 1.45 LINK O2 MAN G 650 C1 MAN G 653 1555 1555 1.44 LINK O4 NAG G 654 C1 NAG G 655 1555 1555 1.45 LINK O4 NAG G 655 C1 BMA G 656 1555 1555 1.44 LINK O4 NAG G 657 C1 NAG G 658 1555 1555 1.44 LINK O4 NAG G 658 C1 BMA G 659 1555 1555 1.44 LINK O3 BMA G 659 C1 MAN G 660 1555 1555 1.45 LINK O4 NAG Q 601 C1 NAG Q 602 1555 1555 1.44 LINK O4 NAG Q 603 C1 NAG Q 604 1555 1555 1.45 LINK O4 NAG Q 605 C1 NAG Q 606 1555 1555 1.43 LINK O4 NAG Q 606 C1 BMA Q 607 1555 1555 1.44 LINK O3 BMA Q 607 C1 MAN Q 608 1555 1555 1.46 LINK O4 NAG Q 609 C1 NAG Q 610 1555 1555 1.44 LINK O4 NAG Q 610 C1 BMA Q 611 1555 1555 1.44 LINK O3 BMA Q 611 C1 MAN Q 612 1555 1555 1.45 LINK O6 BMA Q 611 C1 MAN Q 613 1555 1555 1.45 LINK O4 NAG Q 614 C1 NAG Q 615 1555 1555 1.43 LINK O4 NAG Q 615 C1 BMA Q 616 1555 1555 1.45 LINK O4 NAG Q 617 C1 NAG Q 618 1555 1555 1.44 LINK O4 NAG Q 618 C1 BMA Q 619 1555 1555 1.45 LINK O6 BMA Q 619 C1 MAN Q 620 1555 1555 1.44 LINK O4 NAG Q 621 C1 NAG Q 622 1555 1555 1.45 LINK O4 NAG Q 622 C1 BMA Q 623 1555 1555 1.44 LINK O4 NAG Q 624 C1 NAG Q 625 1555 1555 1.45 LINK O4 NAG Q 625 C1 BMA Q 626 1555 1555 1.44 LINK O3 BMA Q 626 C1 MAN Q 627 1555 1555 1.44 LINK O6 BMA Q 626 C1 MAN Q 628 1555 1555 1.44 LINK O2 MAN Q 627 C1 MAN Q 629 1555 1555 1.44 LINK O4 NAG Q 630 C1 NAG Q 631 1555 1555 1.44 LINK O4 NAG Q 632 C1 NAG Q 633 1555 1555 1.45 LINK O4 NAG Q 635 C1 NAG Q 636 1555 1555 1.44 LINK O4 NAG Q 636 C1 BMA Q 637 1555 1555 1.45 LINK O4 NAG Q 638 C1 NAG Q 639 1555 1555 1.44 LINK O4 NAG Q 639 C1 BMA Q 640 1555 1555 1.45 LINK O3 BMA Q 640 C1 MAN Q 641 1555 1555 1.44 LINK O6 BMA Q 640 C1 MAN Q 642 1555 1555 1.44 LINK O4 NAG Q 643 C1 NAG Q 644 1555 1555 1.47 LINK O4 NAG Q 645 C1 NAG Q 646 1555 1555 1.43 LINK O4 NAG Q 646 C1 BMA Q 647 1555 1555 1.44 LINK O3 BMA Q 647 C1 MAN Q 648 1555 1555 1.45 LINK O6 BMA Q 647 C1 MAN Q 649 1555 1555 1.44 LINK O2 MAN Q 648 C1 MAN Q 650 1555 1555 1.44 LINK O3 MAN Q 649 C1 MAN Q 651 1555 1555 1.44 LINK O6 MAN Q 649 C1 MAN Q 652 1555 1555 1.45 LINK O2 MAN Q 650 C1 MAN Q 653 1555 1555 1.44 LINK O4 NAG Q 654 C1 NAG Q 655 1555 1555 1.45 LINK O4 NAG Q 655 C1 BMA Q 656 1555 1555 1.44 LINK O4 NAG Q 657 C1 NAG Q 658 1555 1555 1.44 LINK O4 NAG Q 658 C1 BMA Q 659 1555 1555 1.44 LINK O3 BMA Q 659 C1 MAN Q 660 1555 1555 1.45 CISPEP 1 LYS H 82A PRO H 82B 0 5.51 CISPEP 2 THR L 7 PRO L 8 0 -5.91 CISPEP 3 PHE L 94 PRO L 95 0 -5.48 CISPEP 4 LYS O 82A PRO O 82B 0 5.62 CISPEP 5 THR P 7 PRO P 8 0 -5.94 CISPEP 6 PHE P 94 PRO P 95 0 -5.62 CISPEP 7 LYS W 82A PRO W 82B 0 5.74 CISPEP 8 THR X 7 PRO X 8 0 -5.92 CISPEP 9 PHE X 94 PRO X 95 0 -5.70 SITE 1 AC1 2 GLU A 87 ASN A 88 SITE 1 AC2 3 ASN A 133 ILE A 138 ASP A 140 SITE 1 AC3 7 ASN A 137 ILE A 138 THR A 139 GLY J 55 SITE 2 AC3 7 ASP J 56 ASN J 58 ASP K 92 SITE 1 AC4 4 THR A 135 ASN A 156 TYR A 173 ASP A 321A SITE 1 AC5 5 GLN A 130 SER A 158 PHE A 159 ASN A 160 SITE 2 AC5 5 LYS A 171 SITE 1 AC6 3 ARG A 192 ASN A 197 LYS N 19 SITE 1 AC7 2 ASN A 234 THR A 236 SITE 1 AC8 3 PRO A 212 ASN A 262 ASN A 377 SITE 1 AC9 8 LYS A 97 ASN A 276 ASN M 30 ALA M 31 SITE 2 AC9 8 ASP M 49 SER M 51 PHE M 90 TYR N 100 SITE 1 AD1 4 GLN A 293 ASN A 295 SER A 334 ARG A 444 SITE 1 AD2 3 ASN A 301 ILE A 323 GLN A 440 SITE 1 AD3 14 HIS A 330 ASN A 332 THR A 415 ARG A 444 SITE 2 AD3 14 ARG J 100 ILE J 100A GLY J 100C VAL J 100E SITE 3 AD3 14 SER K 30 ASN K 50 ASN K 51 ASN K 52 SITE 4 AD3 14 PRO K 66 GLY K 67 SITE 1 AD4 1 ASN A 355 SITE 1 AD5 4 ARG A 151 ASN A 363 NAG A 638 NAG A 639 SITE 1 AD6 3 ASN A 386 NAG A 635 NAG A 643 SITE 1 AD7 2 ASN A 392 NAG A 638 SITE 1 AD8 2 GLN A 293 ASN A 448 SITE 1 AD9 2 ASN B 611 SER B 613 SITE 1 AE1 3 GLU B 634 ASN B 637 TYR B 638 SITE 1 AE2 2 GLU G 87 ASN G 88 SITE 1 AE3 3 ASN G 133 ILE G 138 ASP G 140 SITE 1 AE4 7 GLY E 55 ASP E 56 ASN E 58 ASP F 92 SITE 2 AE4 7 ASN G 137 ILE G 138 THR G 139 SITE 1 AE5 4 THR G 135 ASN G 156 TYR G 173 ASP G 321A SITE 1 AE6 5 GLN G 130 SER G 158 PHE G 159 ASN G 160 SITE 2 AE6 5 LYS G 171 SITE 1 AE7 3 LYS C 19 ARG G 192 ASN G 197 SITE 1 AE8 2 ASN G 234 THR G 236 SITE 1 AE9 3 PRO G 212 ASN G 262 ASN G 377 SITE 1 AF1 8 TYR C 100 ASN D 30 ALA D 31 ASP D 49 SITE 2 AF1 8 SER D 51 PHE D 90 LYS G 97 ASN G 276 SITE 1 AF2 4 GLN G 293 ASN G 295 SER G 334 ARG G 444 SITE 1 AF3 3 ASN G 301 ILE G 323 GLN G 440 SITE 1 AF4 13 ARG E 100 ILE E 100A GLY E 100C VAL E 100E SITE 2 AF4 13 SER F 30 ASN F 50 ASN F 51 PRO F 66 SITE 3 AF4 13 GLY F 67 HIS G 330 ASN G 332 THR G 415 SITE 4 AF4 13 ARG G 444 SITE 1 AF5 1 ASN G 355 SITE 1 AF6 4 ARG G 151 ASN G 363 NAG G 638 NAG G 639 SITE 1 AF7 3 ASN G 386 NAG G 635 NAG G 643 SITE 1 AF8 2 ASN G 392 NAG G 638 SITE 1 AF9 2 GLN G 293 ASN G 448 SITE 1 AG1 2 ASN I 611 SER I 613 SITE 1 AG2 3 GLU I 634 ASN I 637 TYR I 638 SITE 1 AG3 2 GLU Q 87 ASN Q 88 SITE 1 AG4 3 ASN Q 133 ILE Q 138 ASP Q 140 SITE 1 AG5 7 ASN Q 137 ILE Q 138 THR Q 139 GLY S 55 SITE 2 AG5 7 ASP S 56 ASN S 58 ASP T 92 SITE 1 AG6 4 THR Q 135 ASN Q 156 TYR Q 173 ASP Q 321A SITE 1 AG7 5 GLN Q 130 SER Q 158 PHE Q 159 ASN Q 160 SITE 2 AG7 5 LYS Q 171 SITE 1 AG8 3 ARG Q 192 ASN Q 197 LYS V 19 SITE 1 AG9 2 ASN Q 234 THR Q 236 SITE 1 AH1 3 PRO Q 212 ASN Q 262 ASN Q 377 SITE 1 AH2 8 LYS Q 97 ASN Q 276 ASN U 30 ALA U 31 SITE 2 AH2 8 ASP U 49 SER U 51 PHE U 90 TYR V 100 SITE 1 AH3 4 GLN Q 293 ASN Q 295 SER Q 334 ARG Q 444 SITE 1 AH4 3 ASN Q 301 ILE Q 323 GLN Q 440 SITE 1 AH5 14 HIS Q 330 ASN Q 332 THR Q 415 ARG Q 444 SITE 2 AH5 14 ARG S 100 ILE S 100A GLY S 100C VAL S 100E SITE 3 AH5 14 SER T 30 ASN T 50 ASN T 51 ASN T 52 SITE 4 AH5 14 PRO T 66 GLY T 67 SITE 1 AH6 1 ASN Q 355 SITE 1 AH7 4 ARG Q 151 ASN Q 363 NAG Q 638 NAG Q 639 SITE 1 AH8 3 ASN Q 386 NAG Q 635 NAG Q 643 SITE 1 AH9 2 ASN Q 392 NAG Q 638 SITE 1 AI1 2 GLN Q 293 ASN Q 448 SITE 1 AI2 2 ASN R 611 SER R 613 SITE 1 AI3 3 GLU R 634 ASN R 637 TYR R 638 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.002329 0.000000 0.000000 0.00000 SCALE2 0.000000 0.002329 0.000000 0.00000 SCALE3 0.000000 0.000000 0.002329 0.00000