HEADER IMMUNE SYSTEM 02-MAY-19 6OT1 TITLE CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY 0PV-B.01 IN COMPLEX TITLE 2 WITH HIV-1 ENV BG505 DS-SOSIP AND ANTIBODIES VRC03 AND PGT122 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; COMPND 3 CHAIN: B, O, D; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: BG505 GP120; COMPND 7 CHAIN: G, E, P; COMPND 8 SYNONYM: ENV POLYPROTEIN; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: 0PV-B.01 HEAVY; COMPND 12 CHAIN: H, A, M; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 4; COMPND 15 MOLECULE: 0PV-B.01 LIGHT; COMPND 16 CHAIN: L, C, N; COMPND 17 ENGINEERED: YES; COMPND 18 MOL_ID: 5; COMPND 19 MOLECULE: PGT122 HEAVY; COMPND 20 CHAIN: m, F, Q; COMPND 21 ENGINEERED: YES; COMPND 22 MOL_ID: 6; COMPND 23 MOLECULE: PGT122 LIGHT; COMPND 24 CHAIN: n, I, R; COMPND 25 ENGINEERED: YES; COMPND 26 MOL_ID: 7; COMPND 27 MOLECULE: VRC03 HEAVY; COMPND 28 CHAIN: q, J, S; COMPND 29 ENGINEERED: YES; COMPND 30 MOL_ID: 8; COMPND 31 MOLECULE: VRC03 LIGHT; COMPND 32 CHAIN: r, K, T; COMPND 33 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_COMMON: HIV-1; SOURCE 4 ORGANISM_TAXID: 11676; SOURCE 5 GENE: ENV; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 11 ORGANISM_TAXID: 11676; SOURCE 12 GENE: ENV; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 18 ORGANISM_TAXID: 9544; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: MACACA MULATTA; SOURCE 24 ORGANISM_TAXID: 9544; SOURCE 25 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 27 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 28 MOL_ID: 5; SOURCE 29 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 30 ORGANISM_TAXID: 9606; SOURCE 31 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 32 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM_VARIANT: HEK293; SOURCE 34 MOL_ID: 6; SOURCE 35 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 36 ORGANISM_TAXID: 9606; SOURCE 37 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 38 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 39 MOL_ID: 7; SOURCE 40 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 41 ORGANISM_TAXID: 9606; SOURCE 42 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 43 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 44 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 45 MOL_ID: 8; SOURCE 46 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 47 ORGANISM_TAXID: 9606; SOURCE 48 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 49 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 50 EXPRESSION_SYSTEM_CELL_LINE: HEK293 KEYWDS FUSION PEPTIDE, FP, HIV-1, SOSIP, VACCINE, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR J.GORMAN,P.D.KWONG REVDAT 1 07-AUG-19 6OT1 0 JRNL AUTH R.KONG,H.DUAN,Z.SHENG,K.XU,P.ACHARYA,X.CHEN,C.CHENG, JRNL AUTH 2 A.S.DINGENS,J.GORMAN,M.SASTRY,C.H.SHEN,B.ZHANG,T.ZHOU, JRNL AUTH 3 G.Y.CHUANG,C.W.CHAO,Y.GU,A.J.JAFARI,M.K.LOUDER,S.O'DELL, JRNL AUTH 4 A.P.ROWSHAN,E.G.VIOX,Y.WANG,C.W.CHOI,M.M.CORCORAN, JRNL AUTH 5 A.R.CORRIGAN,V.P.DANDEY,E.T.ENG,H.GENG,K.E.FOULDS,Y.GUO, JRNL AUTH 6 Y.D.KWON,B.LIN,K.LIU,R.D.MASON,M.C.NASON,T.Y.OHR,L.OU, JRNL AUTH 7 R.RAWI,E.K.SARFO,A.SCHON,J.P.TODD,S.WANG,H.WEI,W.WU, JRNL AUTH 8 J.C.MULLIKIN,R.T.BAILER,N.A.DORIA-ROSE, JRNL AUTH 9 G.B.KARLSSON HEDESTAM,D.G.SCORPIO,J.OVERBAUGH,J.D.BLOOM, JRNL AUTH10 B.CARRAGHER,C.S.POTTER,L.SHAPIRO,P.D.KWONG,J.R.MASCOLA JRNL TITL ANTIBODY LINEAGES WITH VACCINE-INDUCED ANTIGEN-BINDING JRNL TITL 2 HOTSPOTS DEVELOP BROAD HIV NEUTRALIZATION. JRNL REF CELL V. 178 567 2019 JRNL REFN ISSN 1097-4172 JRNL PMID 31348886 JRNL DOI 10.1016/J.CELL.2019.06.030 REMARK 2 REMARK 2 RESOLUTION. 3.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : LEGINON, CTFFIND, PHENIX, CRYOSPARC, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6CDI REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.500 REMARK 3 NUMBER OF PARTICLES : 57864 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 6OT1 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-MAY-19. REMARK 100 THE DEPOSITION ID IS D_1000241294. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HIV-1 ENV BG505 DS-SOSIP AND REMARK 245 ANTIBODIES 0PV-B.01, VRC03 AND REMARK 245 PGT122; ENVELOPE GLYCOPROTEIN REMARK 245 GP120; ENVELOPE GLYCOPROTEIN REMARK 245 GP41; VRC03; PGT122; 0PV-B.01 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2298 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : NULL REMARK 245 MAXIMUM DEFOCUS (NM) : NULL REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 73.46 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, G, H, L, m, n, q, r, O, E, REMARK 350 AND CHAINS: A, C, F, I, J, K, D, P, M, REMARK 350 AND CHAINS: N, Q, R, S, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ILE B 548 REMARK 465 VAL B 549 REMARK 465 GLN B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 SER B 553 REMARK 465 ASN B 554 REMARK 465 LEU B 555 REMARK 465 LEU B 556 REMARK 465 ARG B 557 REMARK 465 ALA B 558 REMARK 465 PRO B 559 REMARK 465 GLU B 560 REMARK 465 ALA B 561 REMARK 465 GLN B 562 REMARK 465 GLN B 563 REMARK 465 HIS B 564 REMARK 465 LEU B 565 REMARK 465 LEU B 566 REMARK 465 LYS B 567 REMARK 465 LEU B 568 REMARK 465 GLU G 185A REMARK 465 ASN G 185B REMARK 465 GLN G 185C REMARK 465 GLY G 185D REMARK 465 ASN G 185E REMARK 465 ARG G 185F REMARK 465 SER G 185G REMARK 465 ASN G 185H REMARK 465 ASN G 185I REMARK 465 THR G 400 REMARK 465 SER G 401 REMARK 465 VAL G 402 REMARK 465 GLN G 403 REMARK 465 GLY G 404 REMARK 465 SER G 405 REMARK 465 ASN G 406 REMARK 465 SER G 407 REMARK 465 THR G 408 REMARK 465 GLY G 409 REMARK 465 SER G 410 REMARK 465 GLY G 506 REMARK 465 ARG G 507 REMARK 465 ARG G 508 REMARK 465 ARG G 509 REMARK 465 ARG G 510 REMARK 465 ARG G 511 REMARK 465 ARG G 512 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 GLU H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 ALA H 132 REMARK 465 ALA H 133 REMARK 465 LEU H 134 REMARK 465 GLY H 135 REMARK 465 CYS H 136 REMARK 465 LEU H 137 REMARK 465 VAL H 138 REMARK 465 LYS H 139 REMARK 465 ASP H 140 REMARK 465 TYR H 141 REMARK 465 PHE H 142 REMARK 465 PRO H 143 REMARK 465 GLU H 144 REMARK 465 PRO H 145 REMARK 465 VAL H 146 REMARK 465 THR H 147 REMARK 465 VAL H 148 REMARK 465 SER H 149 REMARK 465 TRP H 150 REMARK 465 ASN H 151 REMARK 465 SER H 152 REMARK 465 GLY H 153 REMARK 465 SER H 154 REMARK 465 LEU H 155 REMARK 465 THR H 156 REMARK 465 SER H 157 REMARK 465 GLY H 158 REMARK 465 VAL H 159 REMARK 465 HIS H 160 REMARK 465 THR H 161 REMARK 465 PHE H 162 REMARK 465 PRO H 163 REMARK 465 ALA H 164 REMARK 465 VAL H 165 REMARK 465 LEU H 166 REMARK 465 GLN H 167 REMARK 465 SER H 168 REMARK 465 SER H 169 REMARK 465 GLY H 170 REMARK 465 LEU H 171 REMARK 465 TYR H 172 REMARK 465 SER H 173 REMARK 465 LEU H 174 REMARK 465 SER H 175 REMARK 465 SER H 176 REMARK 465 VAL H 177 REMARK 465 VAL H 178 REMARK 465 THR H 179 REMARK 465 VAL H 180 REMARK 465 PRO H 181 REMARK 465 SER H 182 REMARK 465 SER H 183 REMARK 465 SER H 184 REMARK 465 LEU H 185 REMARK 465 GLY H 186 REMARK 465 THR H 187 REMARK 465 GLN H 188 REMARK 465 THR H 189 REMARK 465 TYR H 190 REMARK 465 VAL H 191 REMARK 465 CYS H 192 REMARK 465 ASN H 193 REMARK 465 VAL H 194 REMARK 465 ASN H 195 REMARK 465 HIS H 196 REMARK 465 LYS H 197 REMARK 465 PRO H 198 REMARK 465 SER H 199 REMARK 465 ASN H 200 REMARK 465 THR H 201 REMARK 465 LYS H 202 REMARK 465 VAL H 203 REMARK 465 ASP H 204 REMARK 465 LYS H 205 REMARK 465 ARG H 206 REMARK 465 VAL H 207 REMARK 465 GLU H 208 REMARK 465 ILE H 209 REMARK 465 LYS H 210 REMARK 465 THR H 211 REMARK 465 CYS H 212 REMARK 465 GLY H 213 REMARK 465 GLY H 214 REMARK 465 LEU H 215 REMARK 465 GLU H 216 REMARK 465 VAL H 217 REMARK 465 LEU H 218 REMARK 465 PHE H 219 REMARK 465 GLN H 220 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 GLU L 122 REMARK 465 ASP L 123 REMARK 465 GLN L 124 REMARK 465 VAL L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 VAL L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 SER L 145 REMARK 465 VAL L 146 REMARK 465 LYS L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 GLY L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 LYS L 155 REMARK 465 THR L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 ASN L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 SER L 183 REMARK 465 THR L 184 REMARK 465 GLU L 185 REMARK 465 TYR L 186 REMARK 465 GLN L 187 REMARK 465 SER L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ALA m 112 REMARK 465 SER m 113 REMARK 465 THR m 114 REMARK 465 LYS m 115 REMARK 465 GLY m 116 REMARK 465 PRO m 117 REMARK 465 SER m 118 REMARK 465 VAL m 119 REMARK 465 PHE m 120 REMARK 465 PRO m 121 REMARK 465 LEU m 122 REMARK 465 ALA m 123 REMARK 465 PRO m 124 REMARK 465 SER m 125 REMARK 465 SER m 126 REMARK 465 LYS m 127 REMARK 465 SER m 128 REMARK 465 THR m 129 REMARK 465 SER m 130 REMARK 465 GLY m 131 REMARK 465 GLY m 132 REMARK 465 THR m 133 REMARK 465 ALA m 134 REMARK 465 ALA m 135 REMARK 465 LEU m 136 REMARK 465 GLY m 137 REMARK 465 CYS m 138 REMARK 465 LEU m 139 REMARK 465 VAL m 140 REMARK 465 LYS m 141 REMARK 465 ASP m 142 REMARK 465 TYR m 143 REMARK 465 PHE m 144 REMARK 465 PRO m 145 REMARK 465 GLU m 146 REMARK 465 PRO m 147 REMARK 465 VAL m 148 REMARK 465 THR m 149 REMARK 465 VAL m 150 REMARK 465 SER m 151 REMARK 465 TRP m 152 REMARK 465 ASN m 153 REMARK 465 SER m 154 REMARK 465 GLY m 155 REMARK 465 ALA m 156 REMARK 465 LEU m 157 REMARK 465 THR m 158 REMARK 465 SER m 159 REMARK 465 GLY m 160 REMARK 465 VAL m 161 REMARK 465 HIS m 162 REMARK 465 THR m 163 REMARK 465 PHE m 164 REMARK 465 PRO m 165 REMARK 465 ALA m 166 REMARK 465 VAL m 167 REMARK 465 LEU m 168 REMARK 465 GLN m 169 REMARK 465 SER m 170 REMARK 465 SER m 171 REMARK 465 GLY m 172 REMARK 465 LEU m 173 REMARK 465 TYR m 174 REMARK 465 SER m 175 REMARK 465 LEU m 176 REMARK 465 SER m 177 REMARK 465 SER m 178 REMARK 465 VAL m 179 REMARK 465 VAL m 180 REMARK 465 THR m 181 REMARK 465 VAL m 182 REMARK 465 PRO m 183 REMARK 465 SER m 184 REMARK 465 SER m 185 REMARK 465 SER m 186 REMARK 465 LEU m 187 REMARK 465 GLY m 188 REMARK 465 THR m 189 REMARK 465 GLN m 190 REMARK 465 THR m 191 REMARK 465 TYR m 192 REMARK 465 ILE m 193 REMARK 465 CYS m 194 REMARK 465 ASN m 195 REMARK 465 VAL m 196 REMARK 465 ASN m 197 REMARK 465 HIS m 198 REMARK 465 LYS m 199 REMARK 465 PRO m 200 REMARK 465 SER m 201 REMARK 465 ASN m 202 REMARK 465 THR m 203 REMARK 465 LYS m 204 REMARK 465 VAL m 205 REMARK 465 ASP m 206 REMARK 465 LYS m 207 REMARK 465 ARG m 208 REMARK 465 VAL m 209 REMARK 465 GLU m 210 REMARK 465 PRO m 211 REMARK 465 LYS m 212 REMARK 465 SER m 213 REMARK 465 CYS m 214 REMARK 465 ALA n 6 REMARK 465 PRO n 7 REMARK 465 SER n 108 REMARK 465 GLN n 109 REMARK 465 PRO n 110 REMARK 465 LYS n 111 REMARK 465 ALA n 112 REMARK 465 ALA n 113 REMARK 465 PRO n 114 REMARK 465 SER n 115 REMARK 465 VAL n 116 REMARK 465 THR n 117 REMARK 465 LEU n 118 REMARK 465 PHE n 119 REMARK 465 PRO n 120 REMARK 465 PRO n 121 REMARK 465 SER n 122 REMARK 465 SER n 123 REMARK 465 GLU n 124 REMARK 465 GLU n 125 REMARK 465 LEU n 126 REMARK 465 GLN n 127 REMARK 465 ALA n 128 REMARK 465 ASN n 129 REMARK 465 LYS n 130 REMARK 465 ALA n 131 REMARK 465 THR n 132 REMARK 465 LEU n 133 REMARK 465 VAL n 134 REMARK 465 CYS n 135 REMARK 465 LEU n 136 REMARK 465 ILE n 137 REMARK 465 SER n 138 REMARK 465 ASP n 139 REMARK 465 PHE n 140 REMARK 465 TYR n 141 REMARK 465 PRO n 142 REMARK 465 GLY n 143 REMARK 465 ALA n 144 REMARK 465 VAL n 145 REMARK 465 THR n 146 REMARK 465 VAL n 147 REMARK 465 ALA n 148 REMARK 465 TRP n 149 REMARK 465 LYS n 150 REMARK 465 ALA n 151 REMARK 465 ASP n 152 REMARK 465 SER n 153 REMARK 465 SER n 154 REMARK 465 PRO n 155 REMARK 465 VAL n 156 REMARK 465 LYS n 157 REMARK 465 ALA n 158 REMARK 465 GLY n 159 REMARK 465 VAL n 160 REMARK 465 GLU n 161 REMARK 465 THR n 162 REMARK 465 THR n 163 REMARK 465 THR n 164 REMARK 465 PRO n 165 REMARK 465 SER n 166 REMARK 465 LYS n 167 REMARK 465 GLN n 168 REMARK 465 SER n 169 REMARK 465 ASN n 170 REMARK 465 ASN n 171 REMARK 465 LYS n 172 REMARK 465 TYR n 173 REMARK 465 ALA n 174 REMARK 465 ALA n 175 REMARK 465 SER n 176 REMARK 465 SER n 177 REMARK 465 TYR n 178 REMARK 465 LEU n 179 REMARK 465 SER n 180 REMARK 465 LEU n 181 REMARK 465 THR n 182 REMARK 465 PRO n 183 REMARK 465 GLU n 184 REMARK 465 GLN n 185 REMARK 465 TRP n 186 REMARK 465 LYS n 187 REMARK 465 SER n 188 REMARK 465 HIS n 189 REMARK 465 LYS n 190 REMARK 465 SER n 191 REMARK 465 TYR n 192 REMARK 465 SER n 193 REMARK 465 CYS n 194 REMARK 465 GLN n 195 REMARK 465 VAL n 196 REMARK 465 THR n 197 REMARK 465 HIS n 198 REMARK 465 GLU n 199 REMARK 465 GLY n 200 REMARK 465 SER n 201 REMARK 465 THR n 202 REMARK 465 VAL n 203 REMARK 465 GLU n 204 REMARK 465 LYS n 205 REMARK 465 THR n 206 REMARK 465 VAL n 207 REMARK 465 ALA n 208 REMARK 465 PRO n 209 REMARK 465 THR n 210 REMARK 465 GLU n 211 REMARK 465 CYS n 212 REMARK 465 SER n 213 REMARK 465 SER q 112 REMARK 465 SER q 113 REMARK 465 ALA q 114 REMARK 465 SER q 115 REMARK 465 THR q 116 REMARK 465 LYS q 117 REMARK 465 GLY q 118 REMARK 465 PRO q 119 REMARK 465 SER q 120 REMARK 465 VAL q 121 REMARK 465 PHE q 122 REMARK 465 PRO q 123 REMARK 465 LEU q 124 REMARK 465 ALA q 125 REMARK 465 PRO q 126 REMARK 465 SER q 127 REMARK 465 SER q 128 REMARK 465 LYS q 129 REMARK 465 SER q 130 REMARK 465 THR q 131 REMARK 465 SER q 132 REMARK 465 GLY q 133 REMARK 465 GLY q 134 REMARK 465 THR q 135 REMARK 465 ALA q 136 REMARK 465 ALA q 137 REMARK 465 LEU q 138 REMARK 465 GLY q 139 REMARK 465 CYS q 140 REMARK 465 LEU q 141 REMARK 465 VAL q 142 REMARK 465 LYS q 143 REMARK 465 ASP q 144 REMARK 465 TYR q 145 REMARK 465 PHE q 146 REMARK 465 PRO q 147 REMARK 465 GLU q 148 REMARK 465 PRO q 149 REMARK 465 VAL q 150 REMARK 465 THR q 151 REMARK 465 VAL q 152 REMARK 465 SER q 153 REMARK 465 TRP q 154 REMARK 465 ASN q 155 REMARK 465 SER q 156 REMARK 465 GLY q 157 REMARK 465 ALA q 158 REMARK 465 LEU q 159 REMARK 465 THR q 160 REMARK 465 SER q 161 REMARK 465 GLY q 162 REMARK 465 VAL q 163 REMARK 465 HIS q 164 REMARK 465 THR q 165 REMARK 465 PHE q 166 REMARK 465 PRO q 167 REMARK 465 ALA q 168 REMARK 465 VAL q 169 REMARK 465 LEU q 170 REMARK 465 GLN q 171 REMARK 465 SER q 172 REMARK 465 SER q 173 REMARK 465 GLY q 174 REMARK 465 LEU q 175 REMARK 465 TYR q 176 REMARK 465 SER q 177 REMARK 465 LEU q 178 REMARK 465 SER q 179 REMARK 465 SER q 180 REMARK 465 VAL q 181 REMARK 465 VAL q 182 REMARK 465 THR q 183 REMARK 465 VAL q 184 REMARK 465 PRO q 185 REMARK 465 SER q 186 REMARK 465 SER q 187 REMARK 465 SER q 188 REMARK 465 LEU q 189 REMARK 465 GLY q 190 REMARK 465 THR q 191 REMARK 465 GLN q 192 REMARK 465 THR q 193 REMARK 465 TYR q 194 REMARK 465 ILE q 195 REMARK 465 CYS q 196 REMARK 465 ASN q 197 REMARK 465 VAL q 198 REMARK 465 ASN q 199 REMARK 465 HIS q 200 REMARK 465 LYS q 201 REMARK 465 PRO q 202 REMARK 465 SER q 203 REMARK 465 ASN q 204 REMARK 465 THR q 205 REMARK 465 LYS q 206 REMARK 465 VAL q 207 REMARK 465 ASP q 208 REMARK 465 LYS q 209 REMARK 465 LYS q 210 REMARK 465 VAL q 211 REMARK 465 GLU q 212 REMARK 465 PRO q 213 REMARK 465 LYS q 214 REMARK 465 SER q 215 REMARK 465 CYS q 216 REMARK 465 ARG r 103 REMARK 465 THR r 104 REMARK 465 VAL r 105 REMARK 465 ALA r 106 REMARK 465 ALA r 107 REMARK 465 PRO r 108 REMARK 465 SER r 109 REMARK 465 VAL r 110 REMARK 465 PHE r 111 REMARK 465 ILE r 112 REMARK 465 PHE r 113 REMARK 465 PRO r 114 REMARK 465 PRO r 115 REMARK 465 SER r 116 REMARK 465 ASP r 117 REMARK 465 GLU r 118 REMARK 465 GLN r 119 REMARK 465 LEU r 120 REMARK 465 LYS r 121 REMARK 465 SER r 122 REMARK 465 GLY r 123 REMARK 465 THR r 124 REMARK 465 ALA r 125 REMARK 465 SER r 126 REMARK 465 VAL r 127 REMARK 465 VAL r 128 REMARK 465 CYS r 129 REMARK 465 LEU r 130 REMARK 465 LEU r 131 REMARK 465 ASN r 132 REMARK 465 ASN r 133 REMARK 465 PHE r 134 REMARK 465 TYR r 135 REMARK 465 PRO r 136 REMARK 465 ARG r 137 REMARK 465 GLU r 138 REMARK 465 ALA r 139 REMARK 465 LYS r 140 REMARK 465 VAL r 141 REMARK 465 GLN r 142 REMARK 465 TRP r 143 REMARK 465 LYS r 144 REMARK 465 VAL r 145 REMARK 465 ASP r 146 REMARK 465 ASN r 147 REMARK 465 ALA r 148 REMARK 465 LEU r 149 REMARK 465 GLN r 150 REMARK 465 SER r 151 REMARK 465 GLY r 152 REMARK 465 ASN r 153 REMARK 465 SER r 154 REMARK 465 GLN r 155 REMARK 465 GLU r 156 REMARK 465 SER r 157 REMARK 465 VAL r 158 REMARK 465 THR r 159 REMARK 465 GLU r 160 REMARK 465 GLN r 161 REMARK 465 ASP r 162 REMARK 465 SER r 163 REMARK 465 LYS r 164 REMARK 465 ASP r 165 REMARK 465 SER r 166 REMARK 465 THR r 167 REMARK 465 TYR r 168 REMARK 465 SER r 169 REMARK 465 LEU r 170 REMARK 465 SER r 171 REMARK 465 SER r 172 REMARK 465 THR r 173 REMARK 465 LEU r 174 REMARK 465 THR r 175 REMARK 465 LEU r 176 REMARK 465 SER r 177 REMARK 465 LYS r 178 REMARK 465 ALA r 179 REMARK 465 ASP r 180 REMARK 465 TYR r 181 REMARK 465 GLU r 182 REMARK 465 LYS r 183 REMARK 465 HIS r 184 REMARK 465 LYS r 185 REMARK 465 VAL r 186 REMARK 465 TYR r 187 REMARK 465 ALA r 188 REMARK 465 CYS r 189 REMARK 465 GLU r 190 REMARK 465 VAL r 191 REMARK 465 THR r 192 REMARK 465 HIS r 193 REMARK 465 GLN r 194 REMARK 465 GLY r 195 REMARK 465 LEU r 196 REMARK 465 SER r 197 REMARK 465 SER r 198 REMARK 465 PRO r 199 REMARK 465 VAL r 200 REMARK 465 THR r 201 REMARK 465 LYS r 202 REMARK 465 SER r 203 REMARK 465 PHE r 204 REMARK 465 ASN r 205 REMARK 465 ARG r 206 REMARK 465 GLY r 207 REMARK 465 GLU r 208 REMARK 465 CYS r 209 REMARK 465 ILE O 548 REMARK 465 VAL O 549 REMARK 465 GLN O 550 REMARK 465 GLN O 551 REMARK 465 GLN O 552 REMARK 465 SER O 553 REMARK 465 ASN O 554 REMARK 465 LEU O 555 REMARK 465 LEU O 556 REMARK 465 ARG O 557 REMARK 465 ALA O 558 REMARK 465 PRO O 559 REMARK 465 GLU O 560 REMARK 465 ALA O 561 REMARK 465 GLN O 562 REMARK 465 GLN O 563 REMARK 465 HIS O 564 REMARK 465 LEU O 565 REMARK 465 LEU O 566 REMARK 465 LYS O 567 REMARK 465 LEU O 568 REMARK 465 GLU E 185A REMARK 465 ASN E 185B REMARK 465 GLN E 185C REMARK 465 GLY E 185D REMARK 465 ASN E 185E REMARK 465 ARG E 185F REMARK 465 SER E 185G REMARK 465 ASN E 185H REMARK 465 ASN E 185I REMARK 465 THR E 400 REMARK 465 SER E 401 REMARK 465 VAL E 402 REMARK 465 GLN E 403 REMARK 465 GLY E 404 REMARK 465 SER E 405 REMARK 465 ASN E 406 REMARK 465 SER E 407 REMARK 465 THR E 408 REMARK 465 GLY E 409 REMARK 465 SER E 410 REMARK 465 GLY E 506 REMARK 465 ARG E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 THR A 116 REMARK 465 LYS A 117 REMARK 465 GLY A 118 REMARK 465 PRO A 119 REMARK 465 SER A 120 REMARK 465 VAL A 121 REMARK 465 PHE A 122 REMARK 465 PRO A 123 REMARK 465 LEU A 124 REMARK 465 ALA A 125 REMARK 465 PRO A 126 REMARK 465 SER A 127 REMARK 465 SER A 128 REMARK 465 GLU A 129 REMARK 465 SER A 130 REMARK 465 THR A 131 REMARK 465 ALA A 132 REMARK 465 ALA A 133 REMARK 465 LEU A 134 REMARK 465 GLY A 135 REMARK 465 CYS A 136 REMARK 465 LEU A 137 REMARK 465 VAL A 138 REMARK 465 LYS A 139 REMARK 465 ASP A 140 REMARK 465 TYR A 141 REMARK 465 PHE A 142 REMARK 465 PRO A 143 REMARK 465 GLU A 144 REMARK 465 PRO A 145 REMARK 465 VAL A 146 REMARK 465 THR A 147 REMARK 465 VAL A 148 REMARK 465 SER A 149 REMARK 465 TRP A 150 REMARK 465 ASN A 151 REMARK 465 SER A 152 REMARK 465 GLY A 153 REMARK 465 SER A 154 REMARK 465 LEU A 155 REMARK 465 THR A 156 REMARK 465 SER A 157 REMARK 465 GLY A 158 REMARK 465 VAL A 159 REMARK 465 HIS A 160 REMARK 465 THR A 161 REMARK 465 PHE A 162 REMARK 465 PRO A 163 REMARK 465 ALA A 164 REMARK 465 VAL A 165 REMARK 465 LEU A 166 REMARK 465 GLN A 167 REMARK 465 SER A 168 REMARK 465 SER A 169 REMARK 465 GLY A 170 REMARK 465 LEU A 171 REMARK 465 TYR A 172 REMARK 465 SER A 173 REMARK 465 LEU A 174 REMARK 465 SER A 175 REMARK 465 SER A 176 REMARK 465 VAL A 177 REMARK 465 VAL A 178 REMARK 465 THR A 179 REMARK 465 VAL A 180 REMARK 465 PRO A 181 REMARK 465 SER A 182 REMARK 465 SER A 183 REMARK 465 SER A 184 REMARK 465 LEU A 185 REMARK 465 GLY A 186 REMARK 465 THR A 187 REMARK 465 GLN A 188 REMARK 465 THR A 189 REMARK 465 TYR A 190 REMARK 465 VAL A 191 REMARK 465 CYS A 192 REMARK 465 ASN A 193 REMARK 465 VAL A 194 REMARK 465 ASN A 195 REMARK 465 HIS A 196 REMARK 465 LYS A 197 REMARK 465 PRO A 198 REMARK 465 SER A 199 REMARK 465 ASN A 200 REMARK 465 THR A 201 REMARK 465 LYS A 202 REMARK 465 VAL A 203 REMARK 465 ASP A 204 REMARK 465 LYS A 205 REMARK 465 ARG A 206 REMARK 465 VAL A 207 REMARK 465 GLU A 208 REMARK 465 ILE A 209 REMARK 465 LYS A 210 REMARK 465 THR A 211 REMARK 465 CYS A 212 REMARK 465 GLY A 213 REMARK 465 GLY A 214 REMARK 465 LEU A 215 REMARK 465 GLU A 216 REMARK 465 VAL A 217 REMARK 465 LEU A 218 REMARK 465 PHE A 219 REMARK 465 GLN A 220 REMARK 465 ARG C 108 REMARK 465 THR C 109 REMARK 465 VAL C 110 REMARK 465 ALA C 111 REMARK 465 ALA C 112 REMARK 465 PRO C 113 REMARK 465 SER C 114 REMARK 465 VAL C 115 REMARK 465 PHE C 116 REMARK 465 ILE C 117 REMARK 465 PHE C 118 REMARK 465 PRO C 119 REMARK 465 PRO C 120 REMARK 465 SER C 121 REMARK 465 GLU C 122 REMARK 465 ASP C 123 REMARK 465 GLN C 124 REMARK 465 VAL C 125 REMARK 465 LYS C 126 REMARK 465 SER C 127 REMARK 465 GLY C 128 REMARK 465 THR C 129 REMARK 465 VAL C 130 REMARK 465 SER C 131 REMARK 465 VAL C 132 REMARK 465 VAL C 133 REMARK 465 CYS C 134 REMARK 465 LEU C 135 REMARK 465 LEU C 136 REMARK 465 ASN C 137 REMARK 465 ASN C 138 REMARK 465 PHE C 139 REMARK 465 TYR C 140 REMARK 465 PRO C 141 REMARK 465 ARG C 142 REMARK 465 GLU C 143 REMARK 465 ALA C 144 REMARK 465 SER C 145 REMARK 465 VAL C 146 REMARK 465 LYS C 147 REMARK 465 TRP C 148 REMARK 465 LYS C 149 REMARK 465 VAL C 150 REMARK 465 ASP C 151 REMARK 465 GLY C 152 REMARK 465 ALA C 153 REMARK 465 LEU C 154 REMARK 465 LYS C 155 REMARK 465 THR C 156 REMARK 465 GLY C 157 REMARK 465 ASN C 158 REMARK 465 SER C 159 REMARK 465 GLN C 160 REMARK 465 GLU C 161 REMARK 465 SER C 162 REMARK 465 VAL C 163 REMARK 465 THR C 164 REMARK 465 GLU C 165 REMARK 465 GLN C 166 REMARK 465 ASP C 167 REMARK 465 SER C 168 REMARK 465 LYS C 169 REMARK 465 ASP C 170 REMARK 465 ASN C 171 REMARK 465 THR C 172 REMARK 465 TYR C 173 REMARK 465 SER C 174 REMARK 465 LEU C 175 REMARK 465 SER C 176 REMARK 465 SER C 177 REMARK 465 THR C 178 REMARK 465 LEU C 179 REMARK 465 THR C 180 REMARK 465 LEU C 181 REMARK 465 SER C 182 REMARK 465 SER C 183 REMARK 465 THR C 184 REMARK 465 GLU C 185 REMARK 465 TYR C 186 REMARK 465 GLN C 187 REMARK 465 SER C 188 REMARK 465 HIS C 189 REMARK 465 LYS C 190 REMARK 465 VAL C 191 REMARK 465 TYR C 192 REMARK 465 ALA C 193 REMARK 465 CYS C 194 REMARK 465 GLU C 195 REMARK 465 VAL C 196 REMARK 465 THR C 197 REMARK 465 HIS C 198 REMARK 465 GLN C 199 REMARK 465 GLY C 200 REMARK 465 LEU C 201 REMARK 465 SER C 202 REMARK 465 SER C 203 REMARK 465 PRO C 204 REMARK 465 VAL C 205 REMARK 465 THR C 206 REMARK 465 LYS C 207 REMARK 465 SER C 208 REMARK 465 PHE C 209 REMARK 465 ASN C 210 REMARK 465 ARG C 211 REMARK 465 GLY C 212 REMARK 465 GLU C 213 REMARK 465 CYS C 214 REMARK 465 ALA F 112 REMARK 465 SER F 113 REMARK 465 THR F 114 REMARK 465 LYS F 115 REMARK 465 GLY F 116 REMARK 465 PRO F 117 REMARK 465 SER F 118 REMARK 465 VAL F 119 REMARK 465 PHE F 120 REMARK 465 PRO F 121 REMARK 465 LEU F 122 REMARK 465 ALA F 123 REMARK 465 PRO F 124 REMARK 465 SER F 125 REMARK 465 SER F 126 REMARK 465 LYS F 127 REMARK 465 SER F 128 REMARK 465 THR F 129 REMARK 465 SER F 130 REMARK 465 GLY F 131 REMARK 465 GLY F 132 REMARK 465 THR F 133 REMARK 465 ALA F 134 REMARK 465 ALA F 135 REMARK 465 LEU F 136 REMARK 465 GLY F 137 REMARK 465 CYS F 138 REMARK 465 LEU F 139 REMARK 465 VAL F 140 REMARK 465 LYS F 141 REMARK 465 ASP F 142 REMARK 465 TYR F 143 REMARK 465 PHE F 144 REMARK 465 PRO F 145 REMARK 465 GLU F 146 REMARK 465 PRO F 147 REMARK 465 VAL F 148 REMARK 465 THR F 149 REMARK 465 VAL F 150 REMARK 465 SER F 151 REMARK 465 TRP F 152 REMARK 465 ASN F 153 REMARK 465 SER F 154 REMARK 465 GLY F 155 REMARK 465 ALA F 156 REMARK 465 LEU F 157 REMARK 465 THR F 158 REMARK 465 SER F 159 REMARK 465 GLY F 160 REMARK 465 VAL F 161 REMARK 465 HIS F 162 REMARK 465 THR F 163 REMARK 465 PHE F 164 REMARK 465 PRO F 165 REMARK 465 ALA F 166 REMARK 465 VAL F 167 REMARK 465 LEU F 168 REMARK 465 GLN F 169 REMARK 465 SER F 170 REMARK 465 SER F 171 REMARK 465 GLY F 172 REMARK 465 LEU F 173 REMARK 465 TYR F 174 REMARK 465 SER F 175 REMARK 465 LEU F 176 REMARK 465 SER F 177 REMARK 465 SER F 178 REMARK 465 VAL F 179 REMARK 465 VAL F 180 REMARK 465 THR F 181 REMARK 465 VAL F 182 REMARK 465 PRO F 183 REMARK 465 SER F 184 REMARK 465 SER F 185 REMARK 465 SER F 186 REMARK 465 LEU F 187 REMARK 465 GLY F 188 REMARK 465 THR F 189 REMARK 465 GLN F 190 REMARK 465 THR F 191 REMARK 465 TYR F 192 REMARK 465 ILE F 193 REMARK 465 CYS F 194 REMARK 465 ASN F 195 REMARK 465 VAL F 196 REMARK 465 ASN F 197 REMARK 465 HIS F 198 REMARK 465 LYS F 199 REMARK 465 PRO F 200 REMARK 465 SER F 201 REMARK 465 ASN F 202 REMARK 465 THR F 203 REMARK 465 LYS F 204 REMARK 465 VAL F 205 REMARK 465 ASP F 206 REMARK 465 LYS F 207 REMARK 465 ARG F 208 REMARK 465 VAL F 209 REMARK 465 GLU F 210 REMARK 465 PRO F 211 REMARK 465 LYS F 212 REMARK 465 SER F 213 REMARK 465 CYS F 214 REMARK 465 ALA I 6 REMARK 465 PRO I 7 REMARK 465 SER I 108 REMARK 465 GLN I 109 REMARK 465 PRO I 110 REMARK 465 LYS I 111 REMARK 465 ALA I 112 REMARK 465 ALA I 113 REMARK 465 PRO I 114 REMARK 465 SER I 115 REMARK 465 VAL I 116 REMARK 465 THR I 117 REMARK 465 LEU I 118 REMARK 465 PHE I 119 REMARK 465 PRO I 120 REMARK 465 PRO I 121 REMARK 465 SER I 122 REMARK 465 SER I 123 REMARK 465 GLU I 124 REMARK 465 GLU I 125 REMARK 465 LEU I 126 REMARK 465 GLN I 127 REMARK 465 ALA I 128 REMARK 465 ASN I 129 REMARK 465 LYS I 130 REMARK 465 ALA I 131 REMARK 465 THR I 132 REMARK 465 LEU I 133 REMARK 465 VAL I 134 REMARK 465 CYS I 135 REMARK 465 LEU I 136 REMARK 465 ILE I 137 REMARK 465 SER I 138 REMARK 465 ASP I 139 REMARK 465 PHE I 140 REMARK 465 TYR I 141 REMARK 465 PRO I 142 REMARK 465 GLY I 143 REMARK 465 ALA I 144 REMARK 465 VAL I 145 REMARK 465 THR I 146 REMARK 465 VAL I 147 REMARK 465 ALA I 148 REMARK 465 TRP I 149 REMARK 465 LYS I 150 REMARK 465 ALA I 151 REMARK 465 ASP I 152 REMARK 465 SER I 153 REMARK 465 SER I 154 REMARK 465 PRO I 155 REMARK 465 VAL I 156 REMARK 465 LYS I 157 REMARK 465 ALA I 158 REMARK 465 GLY I 159 REMARK 465 VAL I 160 REMARK 465 GLU I 161 REMARK 465 THR I 162 REMARK 465 THR I 163 REMARK 465 THR I 164 REMARK 465 PRO I 165 REMARK 465 SER I 166 REMARK 465 LYS I 167 REMARK 465 GLN I 168 REMARK 465 SER I 169 REMARK 465 ASN I 170 REMARK 465 ASN I 171 REMARK 465 LYS I 172 REMARK 465 TYR I 173 REMARK 465 ALA I 174 REMARK 465 ALA I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 TYR I 178 REMARK 465 LEU I 179 REMARK 465 SER I 180 REMARK 465 LEU I 181 REMARK 465 THR I 182 REMARK 465 PRO I 183 REMARK 465 GLU I 184 REMARK 465 GLN I 185 REMARK 465 TRP I 186 REMARK 465 LYS I 187 REMARK 465 SER I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 SER I 191 REMARK 465 TYR I 192 REMARK 465 SER I 193 REMARK 465 CYS I 194 REMARK 465 GLN I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLU I 199 REMARK 465 GLY I 200 REMARK 465 SER I 201 REMARK 465 THR I 202 REMARK 465 VAL I 203 REMARK 465 GLU I 204 REMARK 465 LYS I 205 REMARK 465 THR I 206 REMARK 465 VAL I 207 REMARK 465 ALA I 208 REMARK 465 PRO I 209 REMARK 465 THR I 210 REMARK 465 GLU I 211 REMARK 465 CYS I 212 REMARK 465 SER I 213 REMARK 465 SER J 112 REMARK 465 SER J 113 REMARK 465 ALA J 114 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 LYS J 117 REMARK 465 GLY J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 SER J 128 REMARK 465 LYS J 129 REMARK 465 SER J 130 REMARK 465 THR J 131 REMARK 465 SER J 132 REMARK 465 GLY J 133 REMARK 465 GLY J 134 REMARK 465 THR J 135 REMARK 465 ALA J 136 REMARK 465 ALA J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 ASP J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 SER J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ALA J 158 REMARK 465 LEU J 159 REMARK 465 THR J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 SER J 173 REMARK 465 GLY J 174 REMARK 465 LEU J 175 REMARK 465 TYR J 176 REMARK 465 SER J 177 REMARK 465 LEU J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 VAL J 182 REMARK 465 THR J 183 REMARK 465 VAL J 184 REMARK 465 PRO J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 GLY J 190 REMARK 465 THR J 191 REMARK 465 GLN J 192 REMARK 465 THR J 193 REMARK 465 TYR J 194 REMARK 465 ILE J 195 REMARK 465 CYS J 196 REMARK 465 ASN J 197 REMARK 465 VAL J 198 REMARK 465 ASN J 199 REMARK 465 HIS J 200 REMARK 465 LYS J 201 REMARK 465 PRO J 202 REMARK 465 SER J 203 REMARK 465 ASN J 204 REMARK 465 THR J 205 REMARK 465 LYS J 206 REMARK 465 VAL J 207 REMARK 465 ASP J 208 REMARK 465 LYS J 209 REMARK 465 LYS J 210 REMARK 465 VAL J 211 REMARK 465 GLU J 212 REMARK 465 PRO J 213 REMARK 465 LYS J 214 REMARK 465 SER J 215 REMARK 465 CYS J 216 REMARK 465 ARG K 103 REMARK 465 THR K 104 REMARK 465 VAL K 105 REMARK 465 ALA K 106 REMARK 465 ALA K 107 REMARK 465 PRO K 108 REMARK 465 SER K 109 REMARK 465 VAL K 110 REMARK 465 PHE K 111 REMARK 465 ILE K 112 REMARK 465 PHE K 113 REMARK 465 PRO K 114 REMARK 465 PRO K 115 REMARK 465 SER K 116 REMARK 465 ASP K 117 REMARK 465 GLU K 118 REMARK 465 GLN K 119 REMARK 465 LEU K 120 REMARK 465 LYS K 121 REMARK 465 SER K 122 REMARK 465 GLY K 123 REMARK 465 THR K 124 REMARK 465 ALA K 125 REMARK 465 SER K 126 REMARK 465 VAL K 127 REMARK 465 VAL K 128 REMARK 465 CYS K 129 REMARK 465 LEU K 130 REMARK 465 LEU K 131 REMARK 465 ASN K 132 REMARK 465 ASN K 133 REMARK 465 PHE K 134 REMARK 465 TYR K 135 REMARK 465 PRO K 136 REMARK 465 ARG K 137 REMARK 465 GLU K 138 REMARK 465 ALA K 139 REMARK 465 LYS K 140 REMARK 465 VAL K 141 REMARK 465 GLN K 142 REMARK 465 TRP K 143 REMARK 465 LYS K 144 REMARK 465 VAL K 145 REMARK 465 ASP K 146 REMARK 465 ASN K 147 REMARK 465 ALA K 148 REMARK 465 LEU K 149 REMARK 465 GLN K 150 REMARK 465 SER K 151 REMARK 465 GLY K 152 REMARK 465 ASN K 153 REMARK 465 SER K 154 REMARK 465 GLN K 155 REMARK 465 GLU K 156 REMARK 465 SER K 157 REMARK 465 VAL K 158 REMARK 465 THR K 159 REMARK 465 GLU K 160 REMARK 465 GLN K 161 REMARK 465 ASP K 162 REMARK 465 SER K 163 REMARK 465 LYS K 164 REMARK 465 ASP K 165 REMARK 465 SER K 166 REMARK 465 THR K 167 REMARK 465 TYR K 168 REMARK 465 SER K 169 REMARK 465 LEU K 170 REMARK 465 SER K 171 REMARK 465 SER K 172 REMARK 465 THR K 173 REMARK 465 LEU K 174 REMARK 465 THR K 175 REMARK 465 LEU K 176 REMARK 465 SER K 177 REMARK 465 LYS K 178 REMARK 465 ALA K 179 REMARK 465 ASP K 180 REMARK 465 TYR K 181 REMARK 465 GLU K 182 REMARK 465 LYS K 183 REMARK 465 HIS K 184 REMARK 465 LYS K 185 REMARK 465 VAL K 186 REMARK 465 TYR K 187 REMARK 465 ALA K 188 REMARK 465 CYS K 189 REMARK 465 GLU K 190 REMARK 465 VAL K 191 REMARK 465 THR K 192 REMARK 465 HIS K 193 REMARK 465 GLN K 194 REMARK 465 GLY K 195 REMARK 465 LEU K 196 REMARK 465 SER K 197 REMARK 465 SER K 198 REMARK 465 PRO K 199 REMARK 465 VAL K 200 REMARK 465 THR K 201 REMARK 465 LYS K 202 REMARK 465 SER K 203 REMARK 465 PHE K 204 REMARK 465 ASN K 205 REMARK 465 ARG K 206 REMARK 465 GLY K 207 REMARK 465 GLU K 208 REMARK 465 CYS K 209 REMARK 465 ILE D 548 REMARK 465 VAL D 549 REMARK 465 GLN D 550 REMARK 465 GLN D 551 REMARK 465 GLN D 552 REMARK 465 SER D 553 REMARK 465 ASN D 554 REMARK 465 LEU D 555 REMARK 465 LEU D 556 REMARK 465 ARG D 557 REMARK 465 ALA D 558 REMARK 465 PRO D 559 REMARK 465 GLU D 560 REMARK 465 ALA D 561 REMARK 465 GLN D 562 REMARK 465 GLN D 563 REMARK 465 HIS D 564 REMARK 465 LEU D 565 REMARK 465 LEU D 566 REMARK 465 LYS D 567 REMARK 465 LEU D 568 REMARK 465 GLU P 185A REMARK 465 ASN P 185B REMARK 465 GLN P 185C REMARK 465 GLY P 185D REMARK 465 ASN P 185E REMARK 465 ARG P 185F REMARK 465 SER P 185G REMARK 465 ASN P 185H REMARK 465 ASN P 185I REMARK 465 THR P 400 REMARK 465 SER P 401 REMARK 465 VAL P 402 REMARK 465 GLN P 403 REMARK 465 GLY P 404 REMARK 465 SER P 405 REMARK 465 ASN P 406 REMARK 465 SER P 407 REMARK 465 THR P 408 REMARK 465 GLY P 409 REMARK 465 SER P 410 REMARK 465 GLY P 506 REMARK 465 ARG P 507 REMARK 465 ARG P 508 REMARK 465 ARG P 509 REMARK 465 ARG P 510 REMARK 465 ARG P 511 REMARK 465 ARG P 512 REMARK 465 THR M 116 REMARK 465 LYS M 117 REMARK 465 GLY M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 GLU M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 ALA M 132 REMARK 465 ALA M 133 REMARK 465 LEU M 134 REMARK 465 GLY M 135 REMARK 465 CYS M 136 REMARK 465 LEU M 137 REMARK 465 VAL M 138 REMARK 465 LYS M 139 REMARK 465 ASP M 140 REMARK 465 TYR M 141 REMARK 465 PHE M 142 REMARK 465 PRO M 143 REMARK 465 GLU M 144 REMARK 465 PRO M 145 REMARK 465 VAL M 146 REMARK 465 THR M 147 REMARK 465 VAL M 148 REMARK 465 SER M 149 REMARK 465 TRP M 150 REMARK 465 ASN M 151 REMARK 465 SER M 152 REMARK 465 GLY M 153 REMARK 465 SER M 154 REMARK 465 LEU M 155 REMARK 465 THR M 156 REMARK 465 SER M 157 REMARK 465 GLY M 158 REMARK 465 VAL M 159 REMARK 465 HIS M 160 REMARK 465 THR M 161 REMARK 465 PHE M 162 REMARK 465 PRO M 163 REMARK 465 ALA M 164 REMARK 465 VAL M 165 REMARK 465 LEU M 166 REMARK 465 GLN M 167 REMARK 465 SER M 168 REMARK 465 SER M 169 REMARK 465 GLY M 170 REMARK 465 LEU M 171 REMARK 465 TYR M 172 REMARK 465 SER M 173 REMARK 465 LEU M 174 REMARK 465 SER M 175 REMARK 465 SER M 176 REMARK 465 VAL M 177 REMARK 465 VAL M 178 REMARK 465 THR M 179 REMARK 465 VAL M 180 REMARK 465 PRO M 181 REMARK 465 SER M 182 REMARK 465 SER M 183 REMARK 465 SER M 184 REMARK 465 LEU M 185 REMARK 465 GLY M 186 REMARK 465 THR M 187 REMARK 465 GLN M 188 REMARK 465 THR M 189 REMARK 465 TYR M 190 REMARK 465 VAL M 191 REMARK 465 CYS M 192 REMARK 465 ASN M 193 REMARK 465 VAL M 194 REMARK 465 ASN M 195 REMARK 465 HIS M 196 REMARK 465 LYS M 197 REMARK 465 PRO M 198 REMARK 465 SER M 199 REMARK 465 ASN M 200 REMARK 465 THR M 201 REMARK 465 LYS M 202 REMARK 465 VAL M 203 REMARK 465 ASP M 204 REMARK 465 LYS M 205 REMARK 465 ARG M 206 REMARK 465 VAL M 207 REMARK 465 GLU M 208 REMARK 465 ILE M 209 REMARK 465 LYS M 210 REMARK 465 THR M 211 REMARK 465 CYS M 212 REMARK 465 GLY M 213 REMARK 465 GLY M 214 REMARK 465 LEU M 215 REMARK 465 GLU M 216 REMARK 465 VAL M 217 REMARK 465 LEU M 218 REMARK 465 PHE M 219 REMARK 465 GLN M 220 REMARK 465 ARG N 108 REMARK 465 THR N 109 REMARK 465 VAL N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 SER N 114 REMARK 465 VAL N 115 REMARK 465 PHE N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 GLU N 122 REMARK 465 ASP N 123 REMARK 465 GLN N 124 REMARK 465 VAL N 125 REMARK 465 LYS N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 THR N 129 REMARK 465 VAL N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 LEU N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 ARG N 142 REMARK 465 GLU N 143 REMARK 465 ALA N 144 REMARK 465 SER N 145 REMARK 465 VAL N 146 REMARK 465 LYS N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 VAL N 150 REMARK 465 ASP N 151 REMARK 465 GLY N 152 REMARK 465 ALA N 153 REMARK 465 LEU N 154 REMARK 465 LYS N 155 REMARK 465 THR N 156 REMARK 465 GLY N 157 REMARK 465 ASN N 158 REMARK 465 SER N 159 REMARK 465 GLN N 160 REMARK 465 GLU N 161 REMARK 465 SER N 162 REMARK 465 VAL N 163 REMARK 465 THR N 164 REMARK 465 GLU N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 ASN N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 LEU N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 SER N 182 REMARK 465 SER N 183 REMARK 465 THR N 184 REMARK 465 GLU N 185 REMARK 465 TYR N 186 REMARK 465 GLN N 187 REMARK 465 SER N 188 REMARK 465 HIS N 189 REMARK 465 LYS N 190 REMARK 465 VAL N 191 REMARK 465 TYR N 192 REMARK 465 ALA N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLN N 199 REMARK 465 GLY N 200 REMARK 465 LEU N 201 REMARK 465 SER N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 VAL N 205 REMARK 465 THR N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 GLY N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 465 ALA Q 112 REMARK 465 SER Q 113 REMARK 465 THR Q 114 REMARK 465 LYS Q 115 REMARK 465 GLY Q 116 REMARK 465 PRO Q 117 REMARK 465 SER Q 118 REMARK 465 VAL Q 119 REMARK 465 PHE Q 120 REMARK 465 PRO Q 121 REMARK 465 LEU Q 122 REMARK 465 ALA Q 123 REMARK 465 PRO Q 124 REMARK 465 SER Q 125 REMARK 465 SER Q 126 REMARK 465 LYS Q 127 REMARK 465 SER Q 128 REMARK 465 THR Q 129 REMARK 465 SER Q 130 REMARK 465 GLY Q 131 REMARK 465 GLY Q 132 REMARK 465 THR Q 133 REMARK 465 ALA Q 134 REMARK 465 ALA Q 135 REMARK 465 LEU Q 136 REMARK 465 GLY Q 137 REMARK 465 CYS Q 138 REMARK 465 LEU Q 139 REMARK 465 VAL Q 140 REMARK 465 LYS Q 141 REMARK 465 ASP Q 142 REMARK 465 TYR Q 143 REMARK 465 PHE Q 144 REMARK 465 PRO Q 145 REMARK 465 GLU Q 146 REMARK 465 PRO Q 147 REMARK 465 VAL Q 148 REMARK 465 THR Q 149 REMARK 465 VAL Q 150 REMARK 465 SER Q 151 REMARK 465 TRP Q 152 REMARK 465 ASN Q 153 REMARK 465 SER Q 154 REMARK 465 GLY Q 155 REMARK 465 ALA Q 156 REMARK 465 LEU Q 157 REMARK 465 THR Q 158 REMARK 465 SER Q 159 REMARK 465 GLY Q 160 REMARK 465 VAL Q 161 REMARK 465 HIS Q 162 REMARK 465 THR Q 163 REMARK 465 PHE Q 164 REMARK 465 PRO Q 165 REMARK 465 ALA Q 166 REMARK 465 VAL Q 167 REMARK 465 LEU Q 168 REMARK 465 GLN Q 169 REMARK 465 SER Q 170 REMARK 465 SER Q 171 REMARK 465 GLY Q 172 REMARK 465 LEU Q 173 REMARK 465 TYR Q 174 REMARK 465 SER Q 175 REMARK 465 LEU Q 176 REMARK 465 SER Q 177 REMARK 465 SER Q 178 REMARK 465 VAL Q 179 REMARK 465 VAL Q 180 REMARK 465 THR Q 181 REMARK 465 VAL Q 182 REMARK 465 PRO Q 183 REMARK 465 SER Q 184 REMARK 465 SER Q 185 REMARK 465 SER Q 186 REMARK 465 LEU Q 187 REMARK 465 GLY Q 188 REMARK 465 THR Q 189 REMARK 465 GLN Q 190 REMARK 465 THR Q 191 REMARK 465 TYR Q 192 REMARK 465 ILE Q 193 REMARK 465 CYS Q 194 REMARK 465 ASN Q 195 REMARK 465 VAL Q 196 REMARK 465 ASN Q 197 REMARK 465 HIS Q 198 REMARK 465 LYS Q 199 REMARK 465 PRO Q 200 REMARK 465 SER Q 201 REMARK 465 ASN Q 202 REMARK 465 THR Q 203 REMARK 465 LYS Q 204 REMARK 465 VAL Q 205 REMARK 465 ASP Q 206 REMARK 465 LYS Q 207 REMARK 465 ARG Q 208 REMARK 465 VAL Q 209 REMARK 465 GLU Q 210 REMARK 465 PRO Q 211 REMARK 465 LYS Q 212 REMARK 465 SER Q 213 REMARK 465 CYS Q 214 REMARK 465 ALA R 6 REMARK 465 PRO R 7 REMARK 465 SER R 108 REMARK 465 GLN R 109 REMARK 465 PRO R 110 REMARK 465 LYS R 111 REMARK 465 ALA R 112 REMARK 465 ALA R 113 REMARK 465 PRO R 114 REMARK 465 SER R 115 REMARK 465 VAL R 116 REMARK 465 THR R 117 REMARK 465 LEU R 118 REMARK 465 PHE R 119 REMARK 465 PRO R 120 REMARK 465 PRO R 121 REMARK 465 SER R 122 REMARK 465 SER R 123 REMARK 465 GLU R 124 REMARK 465 GLU R 125 REMARK 465 LEU R 126 REMARK 465 GLN R 127 REMARK 465 ALA R 128 REMARK 465 ASN R 129 REMARK 465 LYS R 130 REMARK 465 ALA R 131 REMARK 465 THR R 132 REMARK 465 LEU R 133 REMARK 465 VAL R 134 REMARK 465 CYS R 135 REMARK 465 LEU R 136 REMARK 465 ILE R 137 REMARK 465 SER R 138 REMARK 465 ASP R 139 REMARK 465 PHE R 140 REMARK 465 TYR R 141 REMARK 465 PRO R 142 REMARK 465 GLY R 143 REMARK 465 ALA R 144 REMARK 465 VAL R 145 REMARK 465 THR R 146 REMARK 465 VAL R 147 REMARK 465 ALA R 148 REMARK 465 TRP R 149 REMARK 465 LYS R 150 REMARK 465 ALA R 151 REMARK 465 ASP R 152 REMARK 465 SER R 153 REMARK 465 SER R 154 REMARK 465 PRO R 155 REMARK 465 VAL R 156 REMARK 465 LYS R 157 REMARK 465 ALA R 158 REMARK 465 GLY R 159 REMARK 465 VAL R 160 REMARK 465 GLU R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 THR R 164 REMARK 465 PRO R 165 REMARK 465 SER R 166 REMARK 465 LYS R 167 REMARK 465 GLN R 168 REMARK 465 SER R 169 REMARK 465 ASN R 170 REMARK 465 ASN R 171 REMARK 465 LYS R 172 REMARK 465 TYR R 173 REMARK 465 ALA R 174 REMARK 465 ALA R 175 REMARK 465 SER R 176 REMARK 465 SER R 177 REMARK 465 TYR R 178 REMARK 465 LEU R 179 REMARK 465 SER R 180 REMARK 465 LEU R 181 REMARK 465 THR R 182 REMARK 465 PRO R 183 REMARK 465 GLU R 184 REMARK 465 GLN R 185 REMARK 465 TRP R 186 REMARK 465 LYS R 187 REMARK 465 SER R 188 REMARK 465 HIS R 189 REMARK 465 LYS R 190 REMARK 465 SER R 191 REMARK 465 TYR R 192 REMARK 465 SER R 193 REMARK 465 CYS R 194 REMARK 465 GLN R 195 REMARK 465 VAL R 196 REMARK 465 THR R 197 REMARK 465 HIS R 198 REMARK 465 GLU R 199 REMARK 465 GLY R 200 REMARK 465 SER R 201 REMARK 465 THR R 202 REMARK 465 VAL R 203 REMARK 465 GLU R 204 REMARK 465 LYS R 205 REMARK 465 THR R 206 REMARK 465 VAL R 207 REMARK 465 ALA R 208 REMARK 465 PRO R 209 REMARK 465 THR R 210 REMARK 465 GLU R 211 REMARK 465 CYS R 212 REMARK 465 SER R 213 REMARK 465 SER S 112 REMARK 465 SER S 113 REMARK 465 ALA S 114 REMARK 465 SER S 115 REMARK 465 THR S 116 REMARK 465 LYS S 117 REMARK 465 GLY S 118 REMARK 465 PRO S 119 REMARK 465 SER S 120 REMARK 465 VAL S 121 REMARK 465 PHE S 122 REMARK 465 PRO S 123 REMARK 465 LEU S 124 REMARK 465 ALA S 125 REMARK 465 PRO S 126 REMARK 465 SER S 127 REMARK 465 SER S 128 REMARK 465 LYS S 129 REMARK 465 SER S 130 REMARK 465 THR S 131 REMARK 465 SER S 132 REMARK 465 GLY S 133 REMARK 465 GLY S 134 REMARK 465 THR S 135 REMARK 465 ALA S 136 REMARK 465 ALA S 137 REMARK 465 LEU S 138 REMARK 465 GLY S 139 REMARK 465 CYS S 140 REMARK 465 LEU S 141 REMARK 465 VAL S 142 REMARK 465 LYS S 143 REMARK 465 ASP S 144 REMARK 465 TYR S 145 REMARK 465 PHE S 146 REMARK 465 PRO S 147 REMARK 465 GLU S 148 REMARK 465 PRO S 149 REMARK 465 VAL S 150 REMARK 465 THR S 151 REMARK 465 VAL S 152 REMARK 465 SER S 153 REMARK 465 TRP S 154 REMARK 465 ASN S 155 REMARK 465 SER S 156 REMARK 465 GLY S 157 REMARK 465 ALA S 158 REMARK 465 LEU S 159 REMARK 465 THR S 160 REMARK 465 SER S 161 REMARK 465 GLY S 162 REMARK 465 VAL S 163 REMARK 465 HIS S 164 REMARK 465 THR S 165 REMARK 465 PHE S 166 REMARK 465 PRO S 167 REMARK 465 ALA S 168 REMARK 465 VAL S 169 REMARK 465 LEU S 170 REMARK 465 GLN S 171 REMARK 465 SER S 172 REMARK 465 SER S 173 REMARK 465 GLY S 174 REMARK 465 LEU S 175 REMARK 465 TYR S 176 REMARK 465 SER S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 SER S 180 REMARK 465 VAL S 181 REMARK 465 VAL S 182 REMARK 465 THR S 183 REMARK 465 VAL S 184 REMARK 465 PRO S 185 REMARK 465 SER S 186 REMARK 465 SER S 187 REMARK 465 SER S 188 REMARK 465 LEU S 189 REMARK 465 GLY S 190 REMARK 465 THR S 191 REMARK 465 GLN S 192 REMARK 465 THR S 193 REMARK 465 TYR S 194 REMARK 465 ILE S 195 REMARK 465 CYS S 196 REMARK 465 ASN S 197 REMARK 465 VAL S 198 REMARK 465 ASN S 199 REMARK 465 HIS S 200 REMARK 465 LYS S 201 REMARK 465 PRO S 202 REMARK 465 SER S 203 REMARK 465 ASN S 204 REMARK 465 THR S 205 REMARK 465 LYS S 206 REMARK 465 VAL S 207 REMARK 465 ASP S 208 REMARK 465 LYS S 209 REMARK 465 LYS S 210 REMARK 465 VAL S 211 REMARK 465 GLU S 212 REMARK 465 PRO S 213 REMARK 465 LYS S 214 REMARK 465 SER S 215 REMARK 465 CYS S 216 REMARK 465 ARG T 103 REMARK 465 THR T 104 REMARK 465 VAL T 105 REMARK 465 ALA T 106 REMARK 465 ALA T 107 REMARK 465 PRO T 108 REMARK 465 SER T 109 REMARK 465 VAL T 110 REMARK 465 PHE T 111 REMARK 465 ILE T 112 REMARK 465 PHE T 113 REMARK 465 PRO T 114 REMARK 465 PRO T 115 REMARK 465 SER T 116 REMARK 465 ASP T 117 REMARK 465 GLU T 118 REMARK 465 GLN T 119 REMARK 465 LEU T 120 REMARK 465 LYS T 121 REMARK 465 SER T 122 REMARK 465 GLY T 123 REMARK 465 THR T 124 REMARK 465 ALA T 125 REMARK 465 SER T 126 REMARK 465 VAL T 127 REMARK 465 VAL T 128 REMARK 465 CYS T 129 REMARK 465 LEU T 130 REMARK 465 LEU T 131 REMARK 465 ASN T 132 REMARK 465 ASN T 133 REMARK 465 PHE T 134 REMARK 465 TYR T 135 REMARK 465 PRO T 136 REMARK 465 ARG T 137 REMARK 465 GLU T 138 REMARK 465 ALA T 139 REMARK 465 LYS T 140 REMARK 465 VAL T 141 REMARK 465 GLN T 142 REMARK 465 TRP T 143 REMARK 465 LYS T 144 REMARK 465 VAL T 145 REMARK 465 ASP T 146 REMARK 465 ASN T 147 REMARK 465 ALA T 148 REMARK 465 LEU T 149 REMARK 465 GLN T 150 REMARK 465 SER T 151 REMARK 465 GLY T 152 REMARK 465 ASN T 153 REMARK 465 SER T 154 REMARK 465 GLN T 155 REMARK 465 GLU T 156 REMARK 465 SER T 157 REMARK 465 VAL T 158 REMARK 465 THR T 159 REMARK 465 GLU T 160 REMARK 465 GLN T 161 REMARK 465 ASP T 162 REMARK 465 SER T 163 REMARK 465 LYS T 164 REMARK 465 ASP T 165 REMARK 465 SER T 166 REMARK 465 THR T 167 REMARK 465 TYR T 168 REMARK 465 SER T 169 REMARK 465 LEU T 170 REMARK 465 SER T 171 REMARK 465 SER T 172 REMARK 465 THR T 173 REMARK 465 LEU T 174 REMARK 465 THR T 175 REMARK 465 LEU T 176 REMARK 465 SER T 177 REMARK 465 LYS T 178 REMARK 465 ALA T 179 REMARK 465 ASP T 180 REMARK 465 TYR T 181 REMARK 465 GLU T 182 REMARK 465 LYS T 183 REMARK 465 HIS T 184 REMARK 465 LYS T 185 REMARK 465 VAL T 186 REMARK 465 TYR T 187 REMARK 465 ALA T 188 REMARK 465 CYS T 189 REMARK 465 GLU T 190 REMARK 465 VAL T 191 REMARK 465 THR T 192 REMARK 465 HIS T 193 REMARK 465 GLN T 194 REMARK 465 GLY T 195 REMARK 465 LEU T 196 REMARK 465 SER T 197 REMARK 465 SER T 198 REMARK 465 PRO T 199 REMARK 465 VAL T 200 REMARK 465 THR T 201 REMARK 465 LYS T 202 REMARK 465 SER T 203 REMARK 465 PHE T 204 REMARK 465 ASN T 205 REMARK 465 ARG T 206 REMARK 465 GLY T 207 REMARK 465 GLU T 208 REMARK 465 CYS T 209 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OE1 GLU O 647 NH2 ARG D 542 2.02 REMARK 500 NH2 ARG B 542 OE1 GLU D 647 2.02 REMARK 500 CB ASP q 76B OH TYR E 318 2.03 REMARK 500 OH TYR G 318 CB ASP S 76B 2.05 REMARK 500 OE1 GLU B 647 NH2 ARG O 542 2.05 REMARK 500 CB ASP J 76B OH TYR P 318 2.09 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS G 54 CA - CB - SG ANGL. DEV. = 9.4 DEGREES REMARK 500 CYS q 98 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 ASP q 99 CB - CG - OD1 ANGL. DEV. = 6.0 DEGREES REMARK 500 CYS E 54 CA - CB - SG ANGL. DEV. = 9.5 DEGREES REMARK 500 CYS J 98 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 ASP J 99 CB - CG - OD1 ANGL. DEV. = 5.8 DEGREES REMARK 500 CYS P 54 CA - CB - SG ANGL. DEV. = 9.4 DEGREES REMARK 500 CYS S 98 CA - CB - SG ANGL. DEV. = 7.5 DEGREES REMARK 500 ASP S 99 CB - CG - OD1 ANGL. DEV. = 5.8 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA B 525 34.83 -96.61 REMARK 500 ASN B 543 52.36 -91.71 REMARK 500 LEU B 602 -12.77 71.98 REMARK 500 ASN B 616 17.01 55.01 REMARK 500 ASP B 624 -3.04 -140.36 REMARK 500 GLN B 640 -4.39 68.62 REMARK 500 ASN G 80 73.12 35.12 REMARK 500 MET G 100 -7.51 64.33 REMARK 500 CYS G 157 71.95 62.18 REMARK 500 SER G 174 -159.61 -148.47 REMARK 500 THR G 198 -8.10 71.48 REMARK 500 THR G 257 -63.35 -91.36 REMARK 500 LEU G 259 71.66 58.52 REMARK 500 SER G 264 68.69 60.61 REMARK 500 GLU G 275 -152.68 -83.78 REMARK 500 ASN G 302 67.31 61.38 REMARK 500 SER G 364 72.54 58.94 REMARK 500 LEU G 390 -61.70 -93.88 REMARK 500 ASN G 462 50.88 -90.54 REMARK 500 PRO G 493 -168.01 -73.87 REMARK 500 LEU G 494 64.06 63.64 REMARK 500 ARG G 500 76.84 -100.04 REMARK 500 LEU L 47 -60.17 -103.32 REMARK 500 GLU L 50 70.13 55.40 REMARK 500 THR L 69 -7.86 73.87 REMARK 500 GLU m 6 -169.53 -119.79 REMARK 500 LYS m 64 -10.03 65.87 REMARK 500 SER m 65 -36.42 -131.28 REMARK 500 SER m 110 -169.17 -162.44 REMARK 500 ASN n 50 -157.92 -148.62 REMARK 500 THR n 69 -169.94 -101.47 REMARK 500 ILE q 48 -60.43 -122.30 REMARK 500 ASP q 76C 71.82 -158.69 REMARK 500 ALA q 88 -167.71 -161.70 REMARK 500 ASP q 99 -7.93 64.68 REMARK 500 PRO q 100E 83.37 -67.44 REMARK 500 THR r 50 -10.59 68.76 REMARK 500 PHE r 90 -39.13 71.45 REMARK 500 GLU r 91 -17.33 -157.24 REMARK 500 ALA O 525 34.82 -96.82 REMARK 500 ASN O 543 52.27 -91.62 REMARK 500 LEU O 602 -12.78 72.00 REMARK 500 ASN O 616 17.03 54.80 REMARK 500 ASP O 624 -2.96 -140.44 REMARK 500 GLN O 640 -4.34 68.62 REMARK 500 ASN E 80 73.01 35.43 REMARK 500 MET E 100 -7.43 64.22 REMARK 500 CYS E 157 71.99 62.10 REMARK 500 SER E 174 -159.56 -148.53 REMARK 500 THR E 198 -8.10 71.37 REMARK 500 REMARK 500 THIS ENTRY HAS 117 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 CYS G 54 ALA G 55 148.67 REMARK 500 CYS G 74 VAL G 75 -144.48 REMARK 500 TYR q 100 CYS q 100A -145.64 REMARK 500 CYS E 54 ALA E 55 148.75 REMARK 500 CYS E 74 VAL E 75 -144.56 REMARK 500 TYR J 100 CYS J 100A -145.63 REMARK 500 CYS P 54 ALA P 55 148.66 REMARK 500 CYS P 74 VAL P 75 -144.45 REMARK 500 TYR S 100 CYS S 100A -145.70 REMARK 500 REMARK 500 REMARK: NULL REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG B 701 bound REMARK 800 to ASN B 637 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG D 701 bound REMARK 800 to ASN D 637 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 601 through NAG E 602 bound to ASN E 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG E 625 bound REMARK 800 to ASN E 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 603 through MAN E 607 bound to ASN E 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 608 through BMA E 610 bound to ASN E 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 611 through NAG E 612 bound to ASN E 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 613 through NAG E 614 bound to ASN E 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 615 through NAG E 616 bound to ASN E 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 617 through MAN E 620 bound to ASN E 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 647 through MAN E 651 bound to ASN E 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 621 through NAG E 622 bound to ASN E 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 623 through NAG E 624 bound to ASN E 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 626 through MAN E 631 bound to ASN E 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG E 632 bound REMARK 800 to ASN E 339 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG E 633 bound REMARK 800 to ASN E 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 634 through BMA E 636 bound to ASN E 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AD9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 637 through MAN E 641 bound to ASN E 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 642 through BMA E 644 bound to ASN E 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG E REMARK 800 645 through NAG E 646 bound to ASN E 448 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 601 through NAG G 602 bound to ASN G 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG G 625 bound REMARK 800 to ASN G 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 603 through MAN G 607 bound to ASN G 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 608 through BMA G 610 bound to ASN G 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 611 through NAG G 612 bound to ASN G 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 613 through NAG G 614 bound to ASN G 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AE9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 615 through NAG G 616 bound to ASN G 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 617 through MAN G 620 bound to ASN G 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 647 through MAN G 651 bound to ASN G 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 621 through NAG G 622 bound to ASN G 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 623 through NAG G 624 bound to ASN G 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 626 through MAN G 631 bound to ASN G 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG G 632 bound REMARK 800 to ASN G 339 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG G 633 bound REMARK 800 to ASN G 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 634 through BMA G 636 bound to ASN G 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AF9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 637 through MAN G 641 bound to ASN G 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 642 through BMA G 644 bound to ASN G 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG G REMARK 800 645 through NAG G 646 bound to ASN G 448 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG O 701 bound REMARK 800 to ASN O 637 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 601 through NAG P 602 bound to ASN P 88 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG P 625 bound REMARK 800 to ASN P 133 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 603 through MAN P 607 bound to ASN P 137 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 608 through BMA P 610 bound to ASN P 156 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 611 through NAG P 612 bound to ASN P 160 REMARK 800 REMARK 800 SITE_IDENTIFIER: AG9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 613 through NAG P 614 bound to ASN P 197 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 615 through NAG P 616 bound to ASN P 234 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 617 through MAN P 620 bound to ASN P 262 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 647 through MAN P 651 bound to ASN P 276 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 621 through NAG P 622 bound to ASN P 295 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH5 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 623 through NAG P 624 bound to ASN P 301 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH6 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 626 through MAN P 631 bound to ASN P 332 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH7 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG P 632 bound REMARK 800 to ASN P 339 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH8 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG P 633 bound REMARK 800 to ASN P 355 REMARK 800 REMARK 800 SITE_IDENTIFIER: AH9 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 634 through BMA P 636 bound to ASN P 363 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 637 through MAN P 641 bound to ASN P 386 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 642 through BMA P 644 bound to ASN P 392 REMARK 800 REMARK 800 SITE_IDENTIFIER: AI3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG P REMARK 800 645 through NAG P 646 bound to ASN P 448 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 6N16 RELATED DB: PDB REMARK 900 RELATED ID: 6OSY RELATED DB: PDB REMARK 900 RELATED ID: 6NF2 RELATED DB: PDB REMARK 900 RELATED ID: EMD-20191 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY 0PV-B.01 IN COMPLEX REMARK 900 WITH HIV-1 ENV BG505 DS-SOSIP AND ANTIBODIES VRC03 AND PGT122 DBREF 6OT1 B 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6OT1 G 31 511 UNP Q2N0S6 Q2N0S6_9HIV1 30 508 DBREF 6OT1 H 1 220 PDB 6OT1 6OT1 1 220 DBREF 6OT1 L 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 m 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 n 6 213 PDB 6OT1 6OT1 6 213 DBREF 6OT1 q 1 216 PDB 6OT1 6OT1 1 216 DBREF 6OT1 r 1 209 PDB 6OT1 6OT1 1 209 DBREF 6OT1 O 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6OT1 E 31 511 UNP Q2N0S6 Q2N0S6_9HIV1 30 508 DBREF 6OT1 A 1 220 PDB 6OT1 6OT1 1 220 DBREF 6OT1 C 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 F 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 I 6 213 PDB 6OT1 6OT1 6 213 DBREF 6OT1 J 1 216 PDB 6OT1 6OT1 1 216 DBREF 6OT1 K 1 209 PDB 6OT1 6OT1 1 209 DBREF 6OT1 D 512 664 UNP Q2N0S6 Q2N0S6_9HIV1 509 661 DBREF 6OT1 P 31 511 UNP Q2N0S6 Q2N0S6_9HIV1 30 508 DBREF 6OT1 M 1 220 PDB 6OT1 6OT1 1 220 DBREF 6OT1 N 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 Q 1 214 PDB 6OT1 6OT1 1 214 DBREF 6OT1 R 6 213 PDB 6OT1 6OT1 6 213 DBREF 6OT1 S 1 216 PDB 6OT1 6OT1 1 216 DBREF 6OT1 T 1 209 PDB 6OT1 6OT1 1 209 SEQADV 6OT1 PRO B 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6OT1 CYS B 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 6OT1 CYS G 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 6OT1 ASN G 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 6OT1 CYS G 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 6OT1 CYS G 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 6OT1 GLY G 506 UNP Q2N0S6 VAL 503 CONFLICT SEQADV 6OT1 ARG G 507 UNP Q2N0S6 GLY 504 CONFLICT SEQADV 6OT1 ARG G 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 6OT1 ARG G 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 6OT1 ARG G 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 6OT1 PRO O 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6OT1 CYS O 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 6OT1 CYS E 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 6OT1 ASN E 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 6OT1 CYS E 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 6OT1 CYS E 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 6OT1 GLY E 506 UNP Q2N0S6 VAL 503 CONFLICT SEQADV 6OT1 ARG E 507 UNP Q2N0S6 GLY 504 CONFLICT SEQADV 6OT1 ARG E 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 6OT1 ARG E 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 6OT1 ARG E 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 6OT1 PRO D 559 UNP Q2N0S6 ILE 556 ENGINEERED MUTATION SEQADV 6OT1 CYS D 605 UNP Q2N0S6 THR 602 ENGINEERED MUTATION SEQADV 6OT1 CYS P 201 UNP Q2N0S6 ILE 200 CONFLICT SEQADV 6OT1 ASN P 332 UNP Q2N0S6 THR 330 CONFLICT SEQADV 6OT1 CYS P 433 UNP Q2N0S6 ALA 430 CONFLICT SEQADV 6OT1 CYS P 501 UNP Q2N0S6 ALA 498 CONFLICT SEQADV 6OT1 GLY P 506 UNP Q2N0S6 VAL 503 CONFLICT SEQADV 6OT1 ARG P 507 UNP Q2N0S6 GLY 504 CONFLICT SEQADV 6OT1 ARG P 509 UNP Q2N0S6 GLU 506 CONFLICT SEQADV 6OT1 ARG P 510 UNP Q2N0S6 LYS 507 CONFLICT SEQADV 6OT1 ARG P 512 UNP Q2N0S6 EXPRESSION TAG SEQRES 1 B 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 B 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 B 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 B 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 B 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 B 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 B 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 B 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 B 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 G 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 G 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 G 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 G 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 G 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 G 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 G 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 G 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 G 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 G 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 G 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 G 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 G 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 G 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 G 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 G 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 G 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 G 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 G 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 G 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 G 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 G 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 G 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 G 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 G 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 G 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 G 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 G 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 G 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 G 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 G 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 G 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 G 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 G 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 G 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 G 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 G 480 CYS LYS ARG ARG VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 H 230 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 H 230 PRO SER GLU THR LEU SER LEU THR CYS GLY VAL SER GLY SEQRES 3 H 230 GLY THR ILE SER SER SER HIS PHE TYR TRP SER TRP ILE SEQRES 4 H 230 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 H 230 LEU TYR ILE ASN ASP GLU ARG ILE ASN TYR ASN PRO SER SEQRES 6 H 230 LEU GLU SER ARG VAL THR ILE SER LYS ASP THR SER GLN SEQRES 7 H 230 ASN GLN PHE ALA LEU LYS LEU THR SER VAL THR ALA ALA SEQRES 8 H 230 ASP THR ALA VAL TYR TYR CYS VAL ARG GLU PRO VAL ILE SEQRES 9 H 230 ALA ALA ALA GLY THR VAL ASP VAL TRP GLY ARG GLY VAL SEQRES 10 H 230 LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 H 230 VAL PHE PRO LEU ALA PRO SER SER GLU SER THR ALA ALA SEQRES 12 H 230 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 H 230 THR VAL SER TRP ASN SER GLY SER LEU THR SER GLY VAL SEQRES 14 H 230 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 H 230 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 H 230 GLY THR GLN THR TYR VAL CYS ASN VAL ASN HIS LYS PRO SEQRES 17 H 230 SER ASN THR LYS VAL ASP LYS ARG VAL GLU ILE LYS THR SEQRES 18 H 230 CYS GLY GLY LEU GLU VAL LEU PHE GLN SEQRES 1 L 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU SER VAL SEQRES 2 L 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 219 GLN SER LEU LEU HIS SER ASN GLY HIS THR TYR VAL HIS SEQRES 4 L 219 TRP TYR LEU GLN LYS ALA GLY GLN SER PRO GLN LEU LEU SEQRES 5 L 219 ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 L 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 L 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 L 219 TYR CYS GLU GLN THR LEU GLN ILE PRO PHE THR PHE GLY SEQRES 9 L 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 L 219 PRO SER VAL PHE ILE PHE PRO PRO SER GLU ASP GLN VAL SEQRES 11 L 219 LYS SER GLY THR VAL SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 219 PHE TYR PRO ARG GLU ALA SER VAL LYS TRP LYS VAL ASP SEQRES 13 L 219 GLY ALA LEU LYS THR GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 219 GLU GLN ASP SER LYS ASP ASN THR TYR SER LEU SER SER SEQRES 15 L 219 THR LEU THR LEU SER SER THR GLU TYR GLN SER HIS LYS SEQRES 16 L 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 m 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 m 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 m 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 m 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 m 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 m 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 m 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 m 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 m 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 m 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 m 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 m 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 m 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 m 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 m 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 m 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 m 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 m 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 m 235 CYS SEQRES 1 n 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 n 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 n 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 n 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 n 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 n 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 n 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 n 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 n 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 n 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 n 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 n 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 n 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 n 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 n 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 n 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 n 213 PRO THR GLU CYS SER SEQRES 1 q 233 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 q 233 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 q 233 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 q 233 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 q 233 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 q 233 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 q 233 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 q 233 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 q 233 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 q 233 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 q 233 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 q 233 SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY SEQRES 13 q 233 CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SEQRES 14 q 233 SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR SEQRES 15 q 233 PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SEQRES 16 q 233 SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR SEQRES 17 q 233 GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN SEQRES 18 q 233 THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 r 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 r 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 r 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 r 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 r 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 r 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 r 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 r 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 r 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 r 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 r 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 r 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 r 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 r 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 r 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 r 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 r 209 CYS SEQRES 1 O 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 O 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 O 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 O 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 O 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 O 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 O 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 O 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 O 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 O 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 O 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 O 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 E 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 E 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 E 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 E 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 E 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 E 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 E 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 E 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 E 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 E 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 E 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 E 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 E 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 E 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 E 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 E 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 E 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 E 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 E 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 E 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 E 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 E 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 E 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 E 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 E 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 E 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 E 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 E 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 E 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 E 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 E 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 E 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 E 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 E 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 E 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 E 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 E 480 CYS LYS ARG ARG VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 A 230 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 A 230 PRO SER GLU THR LEU SER LEU THR CYS GLY VAL SER GLY SEQRES 3 A 230 GLY THR ILE SER SER SER HIS PHE TYR TRP SER TRP ILE SEQRES 4 A 230 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 A 230 LEU TYR ILE ASN ASP GLU ARG ILE ASN TYR ASN PRO SER SEQRES 6 A 230 LEU GLU SER ARG VAL THR ILE SER LYS ASP THR SER GLN SEQRES 7 A 230 ASN GLN PHE ALA LEU LYS LEU THR SER VAL THR ALA ALA SEQRES 8 A 230 ASP THR ALA VAL TYR TYR CYS VAL ARG GLU PRO VAL ILE SEQRES 9 A 230 ALA ALA ALA GLY THR VAL ASP VAL TRP GLY ARG GLY VAL SEQRES 10 A 230 LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 A 230 VAL PHE PRO LEU ALA PRO SER SER GLU SER THR ALA ALA SEQRES 12 A 230 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 A 230 THR VAL SER TRP ASN SER GLY SER LEU THR SER GLY VAL SEQRES 14 A 230 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 A 230 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 A 230 GLY THR GLN THR TYR VAL CYS ASN VAL ASN HIS LYS PRO SEQRES 17 A 230 SER ASN THR LYS VAL ASP LYS ARG VAL GLU ILE LYS THR SEQRES 18 A 230 CYS GLY GLY LEU GLU VAL LEU PHE GLN SEQRES 1 C 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU SER VAL SEQRES 2 C 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 C 219 GLN SER LEU LEU HIS SER ASN GLY HIS THR TYR VAL HIS SEQRES 4 C 219 TRP TYR LEU GLN LYS ALA GLY GLN SER PRO GLN LEU LEU SEQRES 5 C 219 ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 C 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 C 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 C 219 TYR CYS GLU GLN THR LEU GLN ILE PRO PHE THR PHE GLY SEQRES 9 C 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 C 219 PRO SER VAL PHE ILE PHE PRO PRO SER GLU ASP GLN VAL SEQRES 11 C 219 LYS SER GLY THR VAL SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 C 219 PHE TYR PRO ARG GLU ALA SER VAL LYS TRP LYS VAL ASP SEQRES 13 C 219 GLY ALA LEU LYS THR GLY ASN SER GLN GLU SER VAL THR SEQRES 14 C 219 GLU GLN ASP SER LYS ASP ASN THR TYR SER LEU SER SER SEQRES 15 C 219 THR LEU THR LEU SER SER THR GLU TYR GLN SER HIS LYS SEQRES 16 C 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 C 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 F 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 F 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 F 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 F 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 F 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 F 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 F 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 F 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 F 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 F 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 F 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 F 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 F 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 F 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 F 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 F 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 F 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 F 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 F 235 CYS SEQRES 1 I 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 I 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 I 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 I 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 I 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 I 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 I 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 I 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 I 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 I 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 I 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 I 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 I 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 I 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 I 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 I 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 I 213 PRO THR GLU CYS SER SEQRES 1 J 233 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 J 233 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 J 233 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 J 233 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 J 233 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 J 233 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 J 233 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 J 233 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 J 233 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 J 233 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 J 233 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 J 233 SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY SEQRES 13 J 233 CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SEQRES 14 J 233 SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR SEQRES 15 J 233 PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SEQRES 16 J 233 SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR SEQRES 17 J 233 GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN SEQRES 18 J 233 THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 K 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 K 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 K 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 K 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 K 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 K 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 K 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 K 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 K 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 K 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 K 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 K 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 K 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 K 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 K 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 K 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 K 209 CYS SEQRES 1 D 153 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 D 153 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 D 153 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 D 153 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 D 153 HIS LEU LEU LYS LEU THR VAL TRP GLY ILE LYS GLN LEU SEQRES 6 D 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 D 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 D 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 D 153 ASN ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP SEQRES 10 D 153 LEU GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE SEQRES 11 D 153 ILE TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 D 153 LYS ASN GLU GLN ASP LEU LEU ALA LEU ASP SEQRES 1 P 480 ALA GLU ASN LEU TRP VAL THR VAL TYR TYR GLY VAL PRO SEQRES 2 P 480 VAL TRP LYS ASP ALA GLU THR THR LEU PHE CYS ALA SER SEQRES 3 P 480 ASP ALA LYS ALA TYR GLU THR GLU LYS HIS ASN VAL TRP SEQRES 4 P 480 ALA THR HIS ALA CYS VAL PRO THR ASP PRO ASN PRO GLN SEQRES 5 P 480 GLU ILE HIS LEU GLU ASN VAL THR GLU GLU PHE ASN MET SEQRES 6 P 480 TRP LYS ASN ASN MET VAL GLU GLN MET HIS THR ASP ILE SEQRES 7 P 480 ILE SER LEU TRP ASP GLN SER LEU LYS PRO CYS VAL LYS SEQRES 8 P 480 LEU THR PRO LEU CYS VAL THR LEU GLN CYS THR ASN VAL SEQRES 9 P 480 THR ASN ASN ILE THR ASP ASP MET ARG GLY GLU LEU LYS SEQRES 10 P 480 ASN CYS SER PHE ASN MET THR THR GLU LEU ARG ASP LYS SEQRES 11 P 480 LYS GLN LYS VAL TYR SER LEU PHE TYR ARG LEU ASP VAL SEQRES 12 P 480 VAL GLN ILE ASN GLU ASN GLN GLY ASN ARG SER ASN ASN SEQRES 13 P 480 SER ASN LYS GLU TYR ARG LEU ILE ASN CYS ASN THR SER SEQRES 14 P 480 ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE GLU PRO SEQRES 15 P 480 ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE ALA ILE SEQRES 16 P 480 LEU LYS CYS LYS ASP LYS LYS PHE ASN GLY THR GLY PRO SEQRES 17 P 480 CYS PRO SER VAL SER THR VAL GLN CYS THR HIS GLY ILE SEQRES 18 P 480 LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN GLY SER SEQRES 19 P 480 LEU ALA GLU GLU GLU VAL MET ILE ARG SER GLU ASN ILE SEQRES 20 P 480 THR ASN ASN ALA LYS ASN ILE LEU VAL GLN PHE ASN THR SEQRES 21 P 480 PRO VAL GLN ILE ASN CYS THR ARG PRO ASN ASN ASN THR SEQRES 22 P 480 ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA PHE TYR SEQRES 23 P 480 ALA THR GLY ASP ILE ILE GLY ASP ILE ARG GLN ALA HIS SEQRES 24 P 480 CYS ASN VAL SER LYS ALA THR TRP ASN GLU THR LEU GLY SEQRES 25 P 480 LYS VAL VAL LYS GLN LEU ARG LYS HIS PHE GLY ASN ASN SEQRES 26 P 480 THR ILE ILE ARG PHE ALA ASN SER SER GLY GLY ASP LEU SEQRES 27 P 480 GLU VAL THR THR HIS SER PHE ASN CYS GLY GLY GLU PHE SEQRES 28 P 480 PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR TRP SEQRES 29 P 480 ILE SER ASN THR SER VAL GLN GLY SER ASN SER THR GLY SEQRES 30 P 480 SER ASN ASP SER ILE THR LEU PRO CYS ARG ILE LYS GLN SEQRES 31 P 480 ILE ILE ASN MET TRP GLN ARG ILE GLY GLN CYS MET TYR SEQRES 32 P 480 ALA PRO PRO ILE GLN GLY VAL ILE ARG CYS VAL SER ASN SEQRES 33 P 480 ILE THR GLY LEU ILE LEU THR ARG ASP GLY GLY SER THR SEQRES 34 P 480 ASN SER THR THR GLU THR PHE ARG PRO GLY GLY GLY ASP SEQRES 35 P 480 MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS TYR LYS SEQRES 36 P 480 VAL VAL LYS ILE GLU PRO LEU GLY VAL ALA PRO THR ARG SEQRES 37 P 480 CYS LYS ARG ARG VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 M 230 GLN VAL GLN LEU GLN GLU SER GLY PRO GLY VAL VAL LYS SEQRES 2 M 230 PRO SER GLU THR LEU SER LEU THR CYS GLY VAL SER GLY SEQRES 3 M 230 GLY THR ILE SER SER SER HIS PHE TYR TRP SER TRP ILE SEQRES 4 M 230 ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLY SEQRES 5 M 230 LEU TYR ILE ASN ASP GLU ARG ILE ASN TYR ASN PRO SER SEQRES 6 M 230 LEU GLU SER ARG VAL THR ILE SER LYS ASP THR SER GLN SEQRES 7 M 230 ASN GLN PHE ALA LEU LYS LEU THR SER VAL THR ALA ALA SEQRES 8 M 230 ASP THR ALA VAL TYR TYR CYS VAL ARG GLU PRO VAL ILE SEQRES 9 M 230 ALA ALA ALA GLY THR VAL ASP VAL TRP GLY ARG GLY VAL SEQRES 10 M 230 LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 M 230 VAL PHE PRO LEU ALA PRO SER SER GLU SER THR ALA ALA SEQRES 12 M 230 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 M 230 THR VAL SER TRP ASN SER GLY SER LEU THR SER GLY VAL SEQRES 14 M 230 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 M 230 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 M 230 GLY THR GLN THR TYR VAL CYS ASN VAL ASN HIS LYS PRO SEQRES 17 M 230 SER ASN THR LYS VAL ASP LYS ARG VAL GLU ILE LYS THR SEQRES 18 M 230 CYS GLY GLY LEU GLU VAL LEU PHE GLN SEQRES 1 N 219 ASP ILE VAL MET THR GLN THR PRO LEU SER LEU SER VAL SEQRES 2 N 219 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 N 219 GLN SER LEU LEU HIS SER ASN GLY HIS THR TYR VAL HIS SEQRES 4 N 219 TRP TYR LEU GLN LYS ALA GLY GLN SER PRO GLN LEU LEU SEQRES 5 N 219 ILE TYR GLU VAL SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 N 219 ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR LEU SEQRES 7 N 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 N 219 TYR CYS GLU GLN THR LEU GLN ILE PRO PHE THR PHE GLY SEQRES 9 N 219 GLY GLY THR LYS VAL GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 N 219 PRO SER VAL PHE ILE PHE PRO PRO SER GLU ASP GLN VAL SEQRES 11 N 219 LYS SER GLY THR VAL SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 N 219 PHE TYR PRO ARG GLU ALA SER VAL LYS TRP LYS VAL ASP SEQRES 13 N 219 GLY ALA LEU LYS THR GLY ASN SER GLN GLU SER VAL THR SEQRES 14 N 219 GLU GLN ASP SER LYS ASP ASN THR TYR SER LEU SER SER SEQRES 15 N 219 THR LEU THR LEU SER SER THR GLU TYR GLN SER HIS LYS SEQRES 16 N 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 N 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 Q 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 Q 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 Q 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 Q 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 Q 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 Q 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 Q 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 Q 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 Q 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 Q 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 Q 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 Q 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 Q 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 Q 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 Q 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 Q 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 Q 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 Q 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 Q 235 CYS SEQRES 1 R 213 ALA PRO THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA SEQRES 2 R 213 ARG ILE THR CYS GLY GLU GLU SER LEU GLY SER ARG SER SEQRES 3 R 213 VAL ILE TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER SEQRES 4 R 213 LEU ILE ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE SEQRES 5 R 213 PRO ASP ARG PHE SER GLY SER PRO GLY SER THR PHE GLY SEQRES 6 R 213 THR THR ALA THR LEU THR ILE THR SER VAL GLU ALA GLY SEQRES 7 R 213 ASP GLU ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG SEQRES 8 R 213 ARG PRO THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU SEQRES 9 R 213 ILE VAL LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR SEQRES 10 R 213 LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS SEQRES 11 R 213 ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY SEQRES 12 R 213 ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL SEQRES 13 R 213 LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SER SEQRES 14 R 213 ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU THR SEQRES 15 R 213 PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN SEQRES 16 R 213 VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA SEQRES 17 R 213 PRO THR GLU CYS SER SEQRES 1 S 233 GLN VAL GLN LEU VAL GLN SER GLY ALA VAL ILE LYS THR SEQRES 2 S 233 PRO GLY SER SER VAL LYS ILE SER CYS ARG ALA SER GLY SEQRES 3 S 233 TYR ASN PHE ARG ASP TYR SER ILE HIS TRP VAL ARG LEU SEQRES 4 S 233 ILE PRO ASP LYS GLY PHE GLU TRP ILE GLY TRP ILE LYS SEQRES 5 S 233 PRO LEU TRP GLY ALA VAL SER TYR ALA ARG GLN LEU GLN SEQRES 6 S 233 GLY ARG VAL SER MET THR ARG GLN LEU SER GLN ASP PRO SEQRES 7 S 233 ASP ASP PRO ASP TRP GLY VAL ALA TYR MET GLU PHE SER SEQRES 8 S 233 GLY LEU THR PRO ALA ASP THR ALA GLU TYR PHE CYS VAL SEQRES 9 S 233 ARG ARG GLY SER CYS ASP TYR CYS GLY ASP PHE PRO TRP SEQRES 10 S 233 GLN TYR TRP GLY GLN GLY THR VAL VAL VAL VAL SER SER SEQRES 11 S 233 ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SEQRES 12 S 233 SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY SEQRES 13 S 233 CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SEQRES 14 S 233 SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR SEQRES 15 S 233 PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SEQRES 16 S 233 SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR SEQRES 17 S 233 GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN SEQRES 18 S 233 THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 T 209 GLU ILE VAL LEU THR GLN SER PRO GLY ILE LEU SER LEU SEQRES 2 T 209 SER PRO GLY GLU THR ALA THR LEU PHE CYS LYS ALA SER SEQRES 3 T 209 GLN GLY GLY ASN ALA MET THR TRP TYR GLN LYS ARG ARG SEQRES 4 T 209 GLY GLN VAL PRO ARG LEU LEU ILE TYR ASP THR SER ARG SEQRES 5 T 209 ARG ALA SER GLY VAL PRO ASP ARG PHE VAL GLY SER GLY SEQRES 6 T 209 SER GLY THR ASP PHE PHE LEU THR ILE ASN LYS LEU ASP SEQRES 7 T 209 ARG GLU ASP PHE ALA VAL TYR TYR CYS GLN GLN PHE GLU SEQRES 8 T 209 PHE PHE GLY LEU GLY SER GLU LEU GLU VAL HIS ARG THR SEQRES 9 T 209 VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP SEQRES 10 T 209 GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU SEQRES 11 T 209 LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP SEQRES 12 T 209 LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SEQRES 13 T 209 SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER SEQRES 14 T 209 LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU SEQRES 15 T 209 LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY SEQRES 16 T 209 LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU SEQRES 17 T 209 CYS HET NAG B 701 14 HET NAG G 601 14 HET NAG G 602 14 HET NAG G 603 14 HET NAG G 604 14 HET BMA G 605 11 HET MAN G 606 11 HET MAN G 607 11 HET NAG G 608 14 HET NAG G 609 14 HET BMA G 610 11 HET NAG G 611 14 HET NAG G 612 14 HET NAG G 613 14 HET NAG G 614 14 HET NAG G 615 14 HET NAG G 616 14 HET NAG G 617 14 HET NAG G 618 14 HET BMA G 619 11 HET MAN G 620 11 HET NAG G 621 14 HET NAG G 622 14 HET NAG G 623 14 HET NAG G 624 14 HET NAG G 625 14 HET NAG G 626 14 HET NAG G 627 14 HET BMA G 628 11 HET MAN G 629 11 HET MAN G 630 11 HET MAN G 631 11 HET NAG G 632 14 HET NAG G 633 14 HET NAG G 634 14 HET NAG G 635 14 HET BMA G 636 11 HET NAG G 637 14 HET NAG G 638 14 HET BMA G 639 11 HET MAN G 640 11 HET MAN G 641 11 HET NAG G 642 14 HET NAG G 643 14 HET BMA G 644 11 HET NAG G 645 14 HET NAG G 646 14 HET NAG G 647 14 HET NAG G 648 14 HET BMA G 649 11 HET MAN G 650 11 HET MAN G 651 11 HET NAG O 701 14 HET NAG E 601 14 HET NAG E 602 14 HET NAG E 603 14 HET NAG E 604 14 HET BMA E 605 11 HET MAN E 606 11 HET MAN E 607 11 HET NAG E 608 14 HET NAG E 609 14 HET BMA E 610 11 HET NAG E 611 14 HET NAG E 612 14 HET NAG E 613 14 HET NAG E 614 14 HET NAG E 615 14 HET NAG E 616 14 HET NAG E 617 14 HET NAG E 618 14 HET BMA E 619 11 HET MAN E 620 11 HET NAG E 621 14 HET NAG E 622 14 HET NAG E 623 14 HET NAG E 624 14 HET NAG E 625 14 HET NAG E 626 14 HET NAG E 627 14 HET BMA E 628 11 HET MAN E 629 11 HET MAN E 630 11 HET MAN E 631 11 HET NAG E 632 14 HET NAG E 633 14 HET NAG E 634 14 HET NAG E 635 14 HET BMA E 636 11 HET NAG E 637 14 HET NAG E 638 14 HET BMA E 639 11 HET MAN E 640 11 HET MAN E 641 11 HET NAG E 642 14 HET NAG E 643 14 HET BMA E 644 11 HET NAG E 645 14 HET NAG E 646 14 HET NAG E 647 14 HET NAG E 648 14 HET BMA E 649 11 HET MAN E 650 11 HET MAN E 651 11 HET NAG D 701 14 HET NAG P 601 14 HET NAG P 602 14 HET NAG P 603 14 HET NAG P 604 14 HET BMA P 605 11 HET MAN P 606 11 HET MAN P 607 11 HET NAG P 608 14 HET NAG P 609 14 HET BMA P 610 11 HET NAG P 611 14 HET NAG P 612 14 HET NAG P 613 14 HET NAG P 614 14 HET NAG P 615 14 HET NAG P 616 14 HET NAG P 617 14 HET NAG P 618 14 HET BMA P 619 11 HET MAN P 620 11 HET NAG P 621 14 HET NAG P 622 14 HET NAG P 623 14 HET NAG P 624 14 HET NAG P 625 14 HET NAG P 626 14 HET NAG P 627 14 HET BMA P 628 11 HET MAN P 629 11 HET MAN P 630 11 HET MAN P 631 11 HET NAG P 632 14 HET NAG P 633 14 HET NAG P 634 14 HET NAG P 635 14 HET BMA P 636 11 HET NAG P 637 14 HET NAG P 638 14 HET BMA P 639 11 HET MAN P 640 11 HET MAN P 641 11 HET NAG P 642 14 HET NAG P 643 14 HET BMA P 644 11 HET NAG P 645 14 HET NAG P 646 14 HET NAG P 647 14 HET NAG P 648 14 HET BMA P 649 11 HET MAN P 650 11 HET MAN P 651 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE FORMUL 25 NAG 102(C8 H15 N O6) FORMUL 27 BMA 24(C6 H12 O6) FORMUL 27 MAN 30(C6 H12 O6) HELIX 1 AA1 THR B 529 SER B 534 1 6 HELIX 2 AA2 LEU B 537 ASN B 543 1 7 HELIX 3 AA3 GLY B 572 ILE B 595 1 24 HELIX 4 AA4 THR B 627 SER B 636 1 10 HELIX 5 AA5 ILE B 641 ASP B 664 1 24 HELIX 6 AA6 ASP G 57 GLU G 62 5 6 HELIX 7 AA7 VAL G 101 SER G 115 1 15 HELIX 8 AA8 LEU G 122 CYS G 126 5 5 HELIX 9 AA9 LYS G 335 LEU G 349 1 15 HELIX 10 AB1 LEU G 349 GLY G 354 1 6 HELIX 11 AB2 ASN G 425 ARG G 429 5 5 HELIX 12 AB3 MET G 475 ARG G 480 1 6 HELIX 13 AB4 THR H 83 THR H 87 5 5 HELIX 14 AB5 GLU L 79 VAL L 83 5 5 HELIX 15 AB6 LEU m 28 ASN m 32 5 5 HELIX 16 AB7 GLU n 79 GLU n 83 5 5 HELIX 17 AB8 THR q 83 THR q 87 5 5 HELIX 18 AB9 THR O 529 SER O 534 1 6 HELIX 19 AC1 LEU O 537 ASN O 543 1 7 HELIX 20 AC2 GLY O 572 ILE O 595 1 24 HELIX 21 AC3 THR O 627 SER O 636 1 10 HELIX 22 AC4 ILE O 641 ASP O 664 1 24 HELIX 23 AC5 ASP E 57 GLU E 62 5 6 HELIX 24 AC6 VAL E 101 SER E 115 1 15 HELIX 25 AC7 LEU E 122 CYS E 126 5 5 HELIX 26 AC8 LYS E 335 LEU E 349 1 15 HELIX 27 AC9 LEU E 349 GLY E 354 1 6 HELIX 28 AD1 ASN E 425 ARG E 429 5 5 HELIX 29 AD2 MET E 475 ARG E 480 1 6 HELIX 30 AD3 THR A 83 THR A 87 5 5 HELIX 31 AD4 GLU C 79 VAL C 83 5 5 HELIX 32 AD5 LEU F 28 ASN F 32 5 5 HELIX 33 AD6 GLU I 79 GLU I 83 5 5 HELIX 34 AD7 THR J 83 THR J 87 5 5 HELIX 35 AD8 THR D 529 SER D 534 1 6 HELIX 36 AD9 LEU D 537 ASN D 543 1 7 HELIX 37 AE1 GLY D 572 ILE D 595 1 24 HELIX 38 AE2 THR D 627 SER D 636 1 10 HELIX 39 AE3 ILE D 641 ASP D 664 1 24 HELIX 40 AE4 ASP P 57 GLU P 62 5 6 HELIX 41 AE5 VAL P 101 SER P 115 1 15 HELIX 42 AE6 LEU P 122 CYS P 126 5 5 HELIX 43 AE7 LYS P 335 LEU P 349 1 15 HELIX 44 AE8 LEU P 349 GLY P 354 1 6 HELIX 45 AE9 ASN P 425 ARG P 429 5 5 HELIX 46 AF1 MET P 475 ARG P 480 1 6 HELIX 47 AF2 THR M 83 THR M 87 5 5 HELIX 48 AF3 GLU N 79 VAL N 83 5 5 HELIX 49 AF4 LEU Q 28 ASN Q 32 5 5 HELIX 50 AF5 GLU R 79 GLU R 83 5 5 HELIX 51 AF6 THR S 83 THR S 87 5 5 SHEET 1 AA1 3 ILE B 603 PRO B 609 0 SHEET 2 AA1 3 TRP G 35 TYR G 39 -1 O VAL G 36 N VAL B 608 SHEET 3 AA1 3 GLY G 495 THR G 499 -1 O THR G 499 N TRP G 35 SHEET 1 AA2 5 TRP G 45 ASP G 47 0 SHEET 2 AA2 5 TYR G 486 ILE G 491 -1 O LYS G 490 N LYS G 46 SHEET 3 AA2 5 PHE G 223 CYS G 228 -1 N ALA G 224 O VAL G 489 SHEET 4 AA2 5 VAL G 242 VAL G 245 -1 O SER G 243 N LYS G 227 SHEET 5 AA2 5 ILE G 84 HIS G 85 -1 N ILE G 84 O THR G 244 SHEET 1 AA3 2 GLU G 91 GLU G 92 0 SHEET 2 AA3 2 PRO G 238 CYS G 239 -1 O CYS G 239 N GLU G 91 SHEET 1 AA4 2 LEU G 154 LYS G 155 0 SHEET 2 AA4 2 PHE G 176 TYR G 177 -1 O PHE G 176 N LYS G 155 SHEET 1 AA5 2 SER G 158 THR G 162 0 SHEET 2 AA5 2 LYS G 169 TYR G 173 -1 O GLN G 170 N MET G 161 SHEET 1 AA6 2 VAL G 181 GLN G 183 0 SHEET 2 AA6 2 TYR G 191 LEU G 193 -1 O ARG G 192 N VAL G 182 SHEET 1 AA7 3 LEU G 260 LEU G 261 0 SHEET 2 AA7 3 SER G 447 THR G 455 -1 O THR G 450 N LEU G 260 SHEET 3 AA7 3 ILE G 284 ILE G 294 -1 N ILE G 294 O SER G 447 SHEET 1 AA8 5 LEU G 260 LEU G 261 0 SHEET 2 AA8 5 SER G 447 THR G 455 -1 O THR G 450 N LEU G 260 SHEET 3 AA8 5 GLU G 466 PRO G 470 -1 O ARG G 469 N THR G 455 SHEET 4 AA8 5 ILE G 359 PHE G 361 1 N ARG G 360 O PHE G 468 SHEET 5 AA8 5 THR G 394 TRP G 395 -1 O TRP G 395 N ILE G 359 SHEET 1 AA9 2 THR G 297 ARG G 298 0 SHEET 2 AA9 2 ILE G 443 ARG G 444 -1 O ILE G 443 N ARG G 298 SHEET 1 AB1 2 ARG G 304 ARG G 308 0 SHEET 2 AB1 2 ALA G 316 THR G 320 -1 O PHE G 317 N ILE G 307 SHEET 1 AB2 2 HIS G 330 SER G 334 0 SHEET 2 AB2 2 SER G 413 PRO G 417 -1 O LEU G 416 N CYS G 331 SHEET 1 AB3 3 SER G 375 CYS G 378 0 SHEET 2 AB3 3 GLU G 381 TYR G 384 -1 O PHE G 383 N PHE G 376 SHEET 3 AB3 3 ARG G 419 ILE G 420 -1 O ARG G 419 N TYR G 384 SHEET 1 AB4 4 GLN H 3 SER H 7 0 SHEET 2 AB4 4 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 3 AB4 4 GLN H 77 LEU H 82 -1 O LEU H 82 N LEU H 18 SHEET 4 AB4 4 VAL H 67 ASP H 72 -1 N ASP H 72 O GLN H 77 SHEET 1 AB5 6 VAL H 11 VAL H 12 0 SHEET 2 AB5 6 VAL H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB5 6 ALA H 88 PRO H 96 -1 N TYR H 90 O VAL H 107 SHEET 4 AB5 6 PHE H 32 GLN H 39 -1 N ILE H 37 O TYR H 91 SHEET 5 AB5 6 GLU H 46 TYR H 52 -1 O GLU H 46 N ARG H 38 SHEET 6 AB5 6 ARG H 56 TYR H 59 -1 O ASN H 58 N GLY H 50 SHEET 1 AB6 4 VAL H 11 VAL H 12 0 SHEET 2 AB6 4 VAL H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB6 4 ALA H 88 PRO H 96 -1 N TYR H 90 O VAL H 107 SHEET 4 AB6 4 VAL H 102 TRP H 103 -1 O VAL H 102 N ARG H 94 SHEET 1 AB7 4 THR L 5 THR L 7 0 SHEET 2 AB7 4 ALA L 19 ARG L 24 -1 O SER L 22 N THR L 7 SHEET 3 AB7 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AB7 4 PHE L 62 SER L 67 -1 N SER L 67 O ASP L 70 SHEET 1 AB8 5 SER L 10 SER L 12 0 SHEET 2 AB8 5 THR L 102 GLU L 105 1 O LYS L 103 N LEU L 11 SHEET 3 AB8 5 GLY L 84 GLN L 90 -1 N GLY L 84 O VAL L 104 SHEET 4 AB8 5 VAL L 33 GLN L 38 -1 N GLN L 38 O VAL L 85 SHEET 5 AB8 5 GLN L 45 ILE L 48 -1 O GLN L 45 N LEU L 37 SHEET 1 AB9 5 LEU m 11 VAL m 12 0 SHEET 2 AB9 5 THR m 105 VAL m 109 1 O THR m 108 N VAL m 12 SHEET 3 AB9 5 ALA m 88 ARG m 99 -1 N TYR m 90 O THR m 105 SHEET 4 AB9 5 TYR m 33 GLN m 39 -1 N ILE m 37 O TYR m 91 SHEET 5 AB9 5 GLU m 46 VAL m 51 -1 O GLU m 46 N ARG m 38 SHEET 1 AC1 4 LEU m 11 VAL m 12 0 SHEET 2 AC1 4 THR m 105 VAL m 109 1 O THR m 108 N VAL m 12 SHEET 3 AC1 4 ALA m 88 ARG m 99 -1 N TYR m 90 O THR m 105 SHEET 4 AC1 4 THR m 100L TRP m 101 -1 O TYR m 100O N LYS m 96 SHEET 1 AC2 3 LEU m 18 CYS m 22 0 SHEET 2 AC2 3 LEU m 77 LEU m 82 -1 O LEU m 82 N LEU m 18 SHEET 3 AC2 3 SER m 70 ASP m 72 -1 N ASP m 72 O LEU m 77 SHEET 1 AC3 5 PHE n 9 VAL n 13 0 SHEET 2 AC3 5 THR n 102 VAL n 106 1 O THR n 103 N VAL n 11 SHEET 3 AC3 5 ALA n 84 HIS n 89 -1 N TYR n 86 O THR n 102 SHEET 4 AC3 5 ILE n 34 GLN n 38 -1 N GLN n 38 O ASP n 85 SHEET 5 AC3 5 PRO n 44 ILE n 48 -1 O SER n 45 N GLN n 37 SHEET 1 AC4 2 ALA n 19 ARG n 20 0 SHEET 2 AC4 2 THR n 74 ILE n 75 -1 O ILE n 75 N ALA n 19 SHEET 1 AC5 2 CYS n 23 GLU n 26 0 SHEET 2 AC5 2 THR n 70 ALA n 71 -1 O ALA n 71 N CYS n 23 SHEET 1 AC6 4 GLN q 3 GLN q 6 0 SHEET 2 AC6 4 CYS q 22 SER q 25 -1 O ARG q 23 N VAL q 5 SHEET 3 AC6 4 GLY q 76G ALA q 78 -1 O ALA q 78 N CYS q 22 SHEET 4 AC6 4 ARG q 71 GLN q 72 -1 N GLN q 72 O VAL q 77 SHEET 1 AC7 5 VAL q 10 ILE q 11 0 SHEET 2 AC7 5 THR q 107 VAL q 110 1 O VAL q 110 N VAL q 10 SHEET 3 AC7 5 ALA q 88 ARG q 95 -1 N TYR q 90 O THR q 107 SHEET 4 AC7 5 ILE q 34 ILE q 40 -1 N VAL q 37 O PHE q 91 SHEET 5 AC7 5 GLY q 44 TRP q 47 -1 O GLU q 46 N ARG q 38 SHEET 1 AC8 4 VAL q 10 ILE q 11 0 SHEET 2 AC8 4 THR q 107 VAL q 110 1 O VAL q 110 N VAL q 10 SHEET 3 AC8 4 ALA q 88 ARG q 95 -1 N TYR q 90 O THR q 107 SHEET 4 AC8 4 TRP q 100F TRP q 103 -1 O GLN q 101 N ARG q 94 SHEET 1 AC9 3 SER q 17 LYS q 19 0 SHEET 2 AC9 3 GLU q 81 SER q 82A-1 O PHE q 82 N VAL q 18 SHEET 3 AC9 3 VAL q 67 SER q 68 -1 N SER q 68 O GLU q 81 SHEET 1 AD1 2 GLY q 49 LYS q 52 0 SHEET 2 AD1 2 ALA q 56 TYR q 59 -1 O ALA q 56 N LYS q 52 SHEET 1 AD2 4 THR r 5 GLN r 6 0 SHEET 2 AD2 4 ALA r 19 LYS r 24 -1 O LYS r 24 N THR r 5 SHEET 3 AD2 4 ASP r 69 ILE r 74 -1 O ILE r 74 N ALA r 19 SHEET 4 AD2 4 PHE r 61 SER r 64 -1 N VAL r 62 O THR r 73 SHEET 1 AD3 6 ILE r 10 LEU r 13 0 SHEET 2 AD3 6 SER r 97 VAL r 101 1 O GLU r 98 N LEU r 11 SHEET 3 AD3 6 VAL r 84 GLN r 89 -1 N TYR r 85 O SER r 97 SHEET 4 AD3 6 THR r 33 LYS r 37 -1 N TYR r 35 O TYR r 86 SHEET 5 AD3 6 ARG r 44 TYR r 48 -1 O ARG r 44 N GLN r 36 SHEET 6 AD3 6 ARG r 52 ARG r 53 -1 O ARG r 52 N TYR r 48 SHEET 1 AD4 4 ILE r 10 LEU r 13 0 SHEET 2 AD4 4 SER r 97 VAL r 101 1 O GLU r 98 N LEU r 11 SHEET 3 AD4 4 VAL r 84 GLN r 89 -1 N TYR r 85 O SER r 97 SHEET 4 AD4 4 PHE r 92 PHE r 93 -1 N PHE r 92 O GLN r 89 SHEET 1 AD5 3 ILE O 603 PRO O 609 0 SHEET 2 AD5 3 TRP E 35 TYR E 39 -1 O VAL E 36 N VAL O 608 SHEET 3 AD5 3 GLY E 495 THR E 499 -1 O THR E 499 N TRP E 35 SHEET 1 AD6 5 TRP E 45 ASP E 47 0 SHEET 2 AD6 5 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AD6 5 PHE E 223 CYS E 228 -1 N ALA E 224 O VAL E 489 SHEET 4 AD6 5 VAL E 242 VAL E 245 -1 O SER E 243 N LYS E 227 SHEET 5 AD6 5 ILE E 84 HIS E 85 -1 N ILE E 84 O THR E 244 SHEET 1 AD7 2 GLU E 91 GLU E 92 0 SHEET 2 AD7 2 PRO E 238 CYS E 239 -1 O CYS E 239 N GLU E 91 SHEET 1 AD8 2 LEU E 154 LYS E 155 0 SHEET 2 AD8 2 PHE E 176 TYR E 177 -1 O PHE E 176 N LYS E 155 SHEET 1 AD9 2 SER E 158 THR E 162 0 SHEET 2 AD9 2 LYS E 169 TYR E 173 -1 O GLN E 170 N MET E 161 SHEET 1 AE1 2 VAL E 181 GLN E 183 0 SHEET 2 AE1 2 TYR E 191 LEU E 193 -1 O ARG E 192 N VAL E 182 SHEET 1 AE2 3 LEU E 260 LEU E 261 0 SHEET 2 AE2 3 SER E 447 THR E 455 -1 O THR E 450 N LEU E 260 SHEET 3 AE2 3 ILE E 284 ILE E 294 -1 N ILE E 294 O SER E 447 SHEET 1 AE3 5 LEU E 260 LEU E 261 0 SHEET 2 AE3 5 SER E 447 THR E 455 -1 O THR E 450 N LEU E 260 SHEET 3 AE3 5 GLU E 466 PRO E 470 -1 O ARG E 469 N THR E 455 SHEET 4 AE3 5 ILE E 359 PHE E 361 1 N ARG E 360 O PHE E 468 SHEET 5 AE3 5 THR E 394 TRP E 395 -1 O TRP E 395 N ILE E 359 SHEET 1 AE4 2 THR E 297 ARG E 298 0 SHEET 2 AE4 2 ILE E 443 ARG E 444 -1 O ILE E 443 N ARG E 298 SHEET 1 AE5 2 ARG E 304 ARG E 308 0 SHEET 2 AE5 2 ALA E 316 THR E 320 -1 O PHE E 317 N ILE E 307 SHEET 1 AE6 2 HIS E 330 SER E 334 0 SHEET 2 AE6 2 SER E 413 PRO E 417 -1 O LEU E 416 N CYS E 331 SHEET 1 AE7 3 SER E 375 CYS E 378 0 SHEET 2 AE7 3 GLU E 381 TYR E 384 -1 O PHE E 383 N PHE E 376 SHEET 3 AE7 3 ARG E 419 ILE E 420 -1 O ARG E 419 N TYR E 384 SHEET 1 AE8 4 GLN A 3 SER A 7 0 SHEET 2 AE8 4 LEU A 18 SER A 25 -1 O THR A 21 N SER A 7 SHEET 3 AE8 4 GLN A 77 LEU A 82 -1 O LEU A 82 N LEU A 18 SHEET 4 AE8 4 VAL A 67 ASP A 72 -1 N ASP A 72 O GLN A 77 SHEET 1 AE9 6 VAL A 11 VAL A 12 0 SHEET 2 AE9 6 VAL A 107 VAL A 111 1 O THR A 110 N VAL A 12 SHEET 3 AE9 6 ALA A 88 PRO A 96 -1 N TYR A 90 O VAL A 107 SHEET 4 AE9 6 PHE A 32 GLN A 39 -1 N ILE A 37 O TYR A 91 SHEET 5 AE9 6 GLU A 46 TYR A 52 -1 O GLU A 46 N ARG A 38 SHEET 6 AE9 6 ARG A 56 TYR A 59 -1 O ASN A 58 N GLY A 50 SHEET 1 AF1 4 VAL A 11 VAL A 12 0 SHEET 2 AF1 4 VAL A 107 VAL A 111 1 O THR A 110 N VAL A 12 SHEET 3 AF1 4 ALA A 88 PRO A 96 -1 N TYR A 90 O VAL A 107 SHEET 4 AF1 4 VAL A 102 TRP A 103 -1 O VAL A 102 N ARG A 94 SHEET 1 AF2 4 THR C 5 THR C 7 0 SHEET 2 AF2 4 ALA C 19 ARG C 24 -1 O SER C 22 N THR C 7 SHEET 3 AF2 4 ASP C 70 ILE C 75 -1 O LEU C 73 N ILE C 21 SHEET 4 AF2 4 PHE C 62 SER C 67 -1 N SER C 67 O ASP C 70 SHEET 1 AF3 5 SER C 10 SER C 12 0 SHEET 2 AF3 5 THR C 102 GLU C 105 1 O LYS C 103 N LEU C 11 SHEET 3 AF3 5 GLY C 84 GLN C 90 -1 N GLY C 84 O VAL C 104 SHEET 4 AF3 5 VAL C 33 GLN C 38 -1 N GLN C 38 O VAL C 85 SHEET 5 AF3 5 GLN C 45 ILE C 48 -1 O GLN C 45 N LEU C 37 SHEET 1 AF4 5 LEU F 11 VAL F 12 0 SHEET 2 AF4 5 THR F 105 VAL F 109 1 O THR F 108 N VAL F 12 SHEET 3 AF4 5 ALA F 88 ARG F 99 -1 N TYR F 90 O THR F 105 SHEET 4 AF4 5 TYR F 33 GLN F 39 -1 N ILE F 37 O TYR F 91 SHEET 5 AF4 5 GLU F 46 VAL F 51 -1 O GLU F 46 N ARG F 38 SHEET 1 AF5 4 LEU F 11 VAL F 12 0 SHEET 2 AF5 4 THR F 105 VAL F 109 1 O THR F 108 N VAL F 12 SHEET 3 AF5 4 ALA F 88 ARG F 99 -1 N TYR F 90 O THR F 105 SHEET 4 AF5 4 THR F 100L TRP F 101 -1 O TYR F 100O N LYS F 96 SHEET 1 AF6 3 LEU F 18 CYS F 22 0 SHEET 2 AF6 3 LEU F 77 LEU F 82 -1 O LEU F 82 N LEU F 18 SHEET 3 AF6 3 SER F 70 ASP F 72 -1 N ASP F 72 O LEU F 77 SHEET 1 AF7 5 PHE I 9 VAL I 13 0 SHEET 2 AF7 5 THR I 102 VAL I 106 1 O THR I 103 N VAL I 11 SHEET 3 AF7 5 ALA I 84 HIS I 89 -1 N TYR I 86 O THR I 102 SHEET 4 AF7 5 ILE I 34 GLN I 38 -1 N GLN I 38 O ASP I 85 SHEET 5 AF7 5 PRO I 44 ILE I 48 -1 O SER I 45 N GLN I 37 SHEET 1 AF8 2 ALA I 19 ARG I 20 0 SHEET 2 AF8 2 THR I 74 ILE I 75 -1 O ILE I 75 N ALA I 19 SHEET 1 AF9 2 CYS I 23 GLU I 26 0 SHEET 2 AF9 2 THR I 70 ALA I 71 -1 O ALA I 71 N CYS I 23 SHEET 1 AG1 4 GLN J 3 GLN J 6 0 SHEET 2 AG1 4 CYS J 22 SER J 25 -1 O ARG J 23 N VAL J 5 SHEET 3 AG1 4 GLY J 76G ALA J 78 -1 O ALA J 78 N CYS J 22 SHEET 4 AG1 4 ARG J 71 GLN J 72 -1 N GLN J 72 O VAL J 77 SHEET 1 AG2 5 VAL J 10 ILE J 11 0 SHEET 2 AG2 5 THR J 107 VAL J 110 1 O VAL J 110 N VAL J 10 SHEET 3 AG2 5 ALA J 88 ARG J 95 -1 N TYR J 90 O THR J 107 SHEET 4 AG2 5 ILE J 34 ILE J 40 -1 N VAL J 37 O PHE J 91 SHEET 5 AG2 5 GLY J 44 TRP J 47 -1 O GLU J 46 N ARG J 38 SHEET 1 AG3 4 VAL J 10 ILE J 11 0 SHEET 2 AG3 4 THR J 107 VAL J 110 1 O VAL J 110 N VAL J 10 SHEET 3 AG3 4 ALA J 88 ARG J 95 -1 N TYR J 90 O THR J 107 SHEET 4 AG3 4 TRP J 100F TRP J 103 -1 O GLN J 101 N ARG J 94 SHEET 1 AG4 3 SER J 17 LYS J 19 0 SHEET 2 AG4 3 GLU J 81 SER J 82A-1 O PHE J 82 N VAL J 18 SHEET 3 AG4 3 VAL J 67 SER J 68 -1 N SER J 68 O GLU J 81 SHEET 1 AG5 2 GLY J 49 LYS J 52 0 SHEET 2 AG5 2 ALA J 56 TYR J 59 -1 O ALA J 56 N LYS J 52 SHEET 1 AG6 4 THR K 5 GLN K 6 0 SHEET 2 AG6 4 ALA K 19 LYS K 24 -1 O LYS K 24 N THR K 5 SHEET 3 AG6 4 ASP K 69 ILE K 74 -1 O ILE K 74 N ALA K 19 SHEET 4 AG6 4 PHE K 61 SER K 64 -1 N VAL K 62 O THR K 73 SHEET 1 AG7 6 ILE K 10 LEU K 13 0 SHEET 2 AG7 6 SER K 97 VAL K 101 1 O GLU K 98 N LEU K 11 SHEET 3 AG7 6 VAL K 84 GLN K 89 -1 N TYR K 85 O SER K 97 SHEET 4 AG7 6 THR K 33 LYS K 37 -1 N TYR K 35 O TYR K 86 SHEET 5 AG7 6 ARG K 44 TYR K 48 -1 O ARG K 44 N GLN K 36 SHEET 6 AG7 6 ARG K 52 ARG K 53 -1 O ARG K 52 N TYR K 48 SHEET 1 AG8 4 ILE K 10 LEU K 13 0 SHEET 2 AG8 4 SER K 97 VAL K 101 1 O GLU K 98 N LEU K 11 SHEET 3 AG8 4 VAL K 84 GLN K 89 -1 N TYR K 85 O SER K 97 SHEET 4 AG8 4 PHE K 92 PHE K 93 -1 N PHE K 92 O GLN K 89 SHEET 1 AG9 3 ILE D 603 PRO D 609 0 SHEET 2 AG9 3 TRP P 35 TYR P 39 -1 O VAL P 36 N VAL D 608 SHEET 3 AG9 3 GLY P 495 THR P 499 -1 O THR P 499 N TRP P 35 SHEET 1 AH1 5 TRP P 45 ASP P 47 0 SHEET 2 AH1 5 TYR P 486 ILE P 491 -1 O LYS P 490 N LYS P 46 SHEET 3 AH1 5 PHE P 223 CYS P 228 -1 N ALA P 224 O VAL P 489 SHEET 4 AH1 5 VAL P 242 VAL P 245 -1 O SER P 243 N LYS P 227 SHEET 5 AH1 5 ILE P 84 HIS P 85 -1 N ILE P 84 O THR P 244 SHEET 1 AH2 2 GLU P 91 GLU P 92 0 SHEET 2 AH2 2 PRO P 238 CYS P 239 -1 O CYS P 239 N GLU P 91 SHEET 1 AH3 2 LEU P 154 LYS P 155 0 SHEET 2 AH3 2 PHE P 176 TYR P 177 -1 O PHE P 176 N LYS P 155 SHEET 1 AH4 2 SER P 158 THR P 162 0 SHEET 2 AH4 2 LYS P 169 TYR P 173 -1 O GLN P 170 N MET P 161 SHEET 1 AH5 2 VAL P 181 GLN P 183 0 SHEET 2 AH5 2 TYR P 191 LEU P 193 -1 O ARG P 192 N VAL P 182 SHEET 1 AH6 3 LEU P 260 LEU P 261 0 SHEET 2 AH6 3 SER P 447 THR P 455 -1 O THR P 450 N LEU P 260 SHEET 3 AH6 3 ILE P 284 ILE P 294 -1 N ILE P 294 O SER P 447 SHEET 1 AH7 5 LEU P 260 LEU P 261 0 SHEET 2 AH7 5 SER P 447 THR P 455 -1 O THR P 450 N LEU P 260 SHEET 3 AH7 5 GLU P 466 PRO P 470 -1 O ARG P 469 N THR P 455 SHEET 4 AH7 5 ILE P 359 PHE P 361 1 N ARG P 360 O PHE P 468 SHEET 5 AH7 5 THR P 394 TRP P 395 -1 O TRP P 395 N ILE P 359 SHEET 1 AH8 2 THR P 297 ARG P 298 0 SHEET 2 AH8 2 ILE P 443 ARG P 444 -1 O ILE P 443 N ARG P 298 SHEET 1 AH9 2 ARG P 304 ARG P 308 0 SHEET 2 AH9 2 ALA P 316 THR P 320 -1 O PHE P 317 N ILE P 307 SHEET 1 AI1 2 HIS P 330 SER P 334 0 SHEET 2 AI1 2 SER P 413 PRO P 417 -1 O LEU P 416 N CYS P 331 SHEET 1 AI2 3 SER P 375 CYS P 378 0 SHEET 2 AI2 3 GLU P 381 TYR P 384 -1 O PHE P 383 N PHE P 376 SHEET 3 AI2 3 ARG P 419 ILE P 420 -1 O ARG P 419 N TYR P 384 SHEET 1 AI3 4 GLN M 3 SER M 7 0 SHEET 2 AI3 4 LEU M 18 SER M 25 -1 O THR M 21 N SER M 7 SHEET 3 AI3 4 GLN M 77 LEU M 82 -1 O LEU M 82 N LEU M 18 SHEET 4 AI3 4 VAL M 67 ASP M 72 -1 N ASP M 72 O GLN M 77 SHEET 1 AI4 6 VAL M 11 VAL M 12 0 SHEET 2 AI4 6 VAL M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AI4 6 ALA M 88 PRO M 96 -1 N TYR M 90 O VAL M 107 SHEET 4 AI4 6 PHE M 32 GLN M 39 -1 N ILE M 37 O TYR M 91 SHEET 5 AI4 6 GLU M 46 TYR M 52 -1 O GLU M 46 N ARG M 38 SHEET 6 AI4 6 ARG M 56 TYR M 59 -1 O ASN M 58 N GLY M 50 SHEET 1 AI5 4 VAL M 11 VAL M 12 0 SHEET 2 AI5 4 VAL M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AI5 4 ALA M 88 PRO M 96 -1 N TYR M 90 O VAL M 107 SHEET 4 AI5 4 VAL M 102 TRP M 103 -1 O VAL M 102 N ARG M 94 SHEET 1 AI6 4 THR N 5 THR N 7 0 SHEET 2 AI6 4 ALA N 19 ARG N 24 -1 O SER N 22 N THR N 7 SHEET 3 AI6 4 ASP N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AI6 4 PHE N 62 SER N 67 -1 N SER N 67 O ASP N 70 SHEET 1 AI7 5 SER N 10 SER N 12 0 SHEET 2 AI7 5 THR N 102 GLU N 105 1 O LYS N 103 N LEU N 11 SHEET 3 AI7 5 GLY N 84 GLN N 90 -1 N GLY N 84 O VAL N 104 SHEET 4 AI7 5 VAL N 33 GLN N 38 -1 N GLN N 38 O VAL N 85 SHEET 5 AI7 5 GLN N 45 ILE N 48 -1 O GLN N 45 N LEU N 37 SHEET 1 AI8 5 LEU Q 11 VAL Q 12 0 SHEET 2 AI8 5 THR Q 105 VAL Q 109 1 O THR Q 108 N VAL Q 12 SHEET 3 AI8 5 ALA Q 88 ARG Q 99 -1 N TYR Q 90 O THR Q 105 SHEET 4 AI8 5 TYR Q 33 GLN Q 39 -1 N ILE Q 37 O TYR Q 91 SHEET 5 AI8 5 GLU Q 46 VAL Q 51 -1 O GLU Q 46 N ARG Q 38 SHEET 1 AI9 4 LEU Q 11 VAL Q 12 0 SHEET 2 AI9 4 THR Q 105 VAL Q 109 1 O THR Q 108 N VAL Q 12 SHEET 3 AI9 4 ALA Q 88 ARG Q 99 -1 N TYR Q 90 O THR Q 105 SHEET 4 AI9 4 THR Q 100L TRP Q 101 -1 O TYR Q 100O N LYS Q 96 SHEET 1 AJ1 3 LEU Q 18 CYS Q 22 0 SHEET 2 AJ1 3 LEU Q 77 LEU Q 82 -1 O LEU Q 82 N LEU Q 18 SHEET 3 AJ1 3 SER Q 70 ASP Q 72 -1 N ASP Q 72 O LEU Q 77 SHEET 1 AJ2 5 PHE R 9 VAL R 13 0 SHEET 2 AJ2 5 THR R 102 VAL R 106 1 O THR R 103 N VAL R 11 SHEET 3 AJ2 5 ALA R 84 HIS R 89 -1 N TYR R 86 O THR R 102 SHEET 4 AJ2 5 ILE R 34 GLN R 38 -1 N GLN R 38 O ASP R 85 SHEET 5 AJ2 5 PRO R 44 ILE R 48 -1 O SER R 45 N GLN R 37 SHEET 1 AJ3 2 ALA R 19 ARG R 20 0 SHEET 2 AJ3 2 THR R 74 ILE R 75 -1 O ILE R 75 N ALA R 19 SHEET 1 AJ4 2 CYS R 23 GLU R 26 0 SHEET 2 AJ4 2 THR R 70 ALA R 71 -1 O ALA R 71 N CYS R 23 SHEET 1 AJ5 4 GLN S 3 GLN S 6 0 SHEET 2 AJ5 4 CYS S 22 SER S 25 -1 O ARG S 23 N VAL S 5 SHEET 3 AJ5 4 GLY S 76G ALA S 78 -1 O ALA S 78 N CYS S 22 SHEET 4 AJ5 4 ARG S 71 GLN S 72 -1 N GLN S 72 O VAL S 77 SHEET 1 AJ6 5 VAL S 10 ILE S 11 0 SHEET 2 AJ6 5 THR S 107 VAL S 110 1 O VAL S 110 N VAL S 10 SHEET 3 AJ6 5 ALA S 88 ARG S 95 -1 N TYR S 90 O THR S 107 SHEET 4 AJ6 5 ILE S 34 ILE S 40 -1 N VAL S 37 O PHE S 91 SHEET 5 AJ6 5 GLY S 44 TRP S 47 -1 O GLU S 46 N ARG S 38 SHEET 1 AJ7 4 VAL S 10 ILE S 11 0 SHEET 2 AJ7 4 THR S 107 VAL S 110 1 O VAL S 110 N VAL S 10 SHEET 3 AJ7 4 ALA S 88 ARG S 95 -1 N TYR S 90 O THR S 107 SHEET 4 AJ7 4 TRP S 100F TRP S 103 -1 O GLN S 101 N ARG S 94 SHEET 1 AJ8 3 SER S 17 LYS S 19 0 SHEET 2 AJ8 3 GLU S 81 SER S 82A-1 O PHE S 82 N VAL S 18 SHEET 3 AJ8 3 VAL S 67 SER S 68 -1 N SER S 68 O GLU S 81 SHEET 1 AJ9 2 GLY S 49 LYS S 52 0 SHEET 2 AJ9 2 ALA S 56 TYR S 59 -1 O ALA S 56 N LYS S 52 SHEET 1 AK1 4 THR T 5 GLN T 6 0 SHEET 2 AK1 4 ALA T 19 LYS T 24 -1 O LYS T 24 N THR T 5 SHEET 3 AK1 4 ASP T 69 ILE T 74 -1 O ILE T 74 N ALA T 19 SHEET 4 AK1 4 PHE T 61 SER T 64 -1 N VAL T 62 O THR T 73 SHEET 1 AK2 6 ILE T 10 LEU T 13 0 SHEET 2 AK2 6 SER T 97 VAL T 101 1 O GLU T 98 N LEU T 11 SHEET 3 AK2 6 VAL T 84 GLN T 89 -1 N TYR T 85 O SER T 97 SHEET 4 AK2 6 THR T 33 LYS T 37 -1 N TYR T 35 O TYR T 86 SHEET 5 AK2 6 ARG T 44 TYR T 48 -1 O ARG T 44 N GLN T 36 SHEET 6 AK2 6 ARG T 52 ARG T 53 -1 O ARG T 52 N TYR T 48 SHEET 1 AK3 4 ILE T 10 LEU T 13 0 SHEET 2 AK3 4 SER T 97 VAL T 101 1 O GLU T 98 N LEU T 11 SHEET 3 AK3 4 VAL T 84 GLN T 89 -1 N TYR T 85 O SER T 97 SHEET 4 AK3 4 PHE T 92 PHE T 93 -1 N PHE T 92 O GLN T 89 SSBOND 1 CYS B 598 CYS B 604 1555 1555 2.02 SSBOND 2 CYS B 605 CYS G 501 1555 1555 2.03 SSBOND 3 CYS G 54 CYS G 74 1555 1555 2.04 SSBOND 4 CYS G 119 CYS G 205 1555 1555 2.03 SSBOND 5 CYS G 126 CYS G 196 1555 1555 2.03 SSBOND 6 CYS G 131 CYS G 157 1555 1555 2.03 SSBOND 7 CYS G 201 CYS G 433 1555 1555 2.02 SSBOND 8 CYS G 218 CYS G 247 1555 1555 2.03 SSBOND 9 CYS G 228 CYS G 239 1555 1555 2.03 SSBOND 10 CYS G 296 CYS G 331 1555 1555 2.02 SSBOND 11 CYS G 378 CYS G 445 1555 1555 2.03 SSBOND 12 CYS G 385 CYS G 418 1555 1555 2.03 SSBOND 13 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 14 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 15 CYS m 22 CYS m 92 1555 1555 2.03 SSBOND 16 CYS n 23 CYS n 88 1555 1555 2.03 SSBOND 17 CYS q 22 CYS q 92 1555 1555 2.03 SSBOND 18 CYS q 98 CYS q 100A 1555 1555 2.03 SSBOND 19 CYS r 23 CYS r 87 1555 1555 2.04 SSBOND 20 CYS O 598 CYS O 604 1555 1555 2.02 SSBOND 21 CYS O 605 CYS E 501 1555 1555 2.03 SSBOND 22 CYS E 54 CYS E 74 1555 1555 2.04 SSBOND 23 CYS E 119 CYS E 205 1555 1555 2.03 SSBOND 24 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 25 CYS E 131 CYS E 157 1555 1555 2.03 SSBOND 26 CYS E 201 CYS E 433 1555 1555 2.02 SSBOND 27 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 28 CYS E 228 CYS E 239 1555 1555 2.03 SSBOND 29 CYS E 296 CYS E 331 1555 1555 2.02 SSBOND 30 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 31 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 32 CYS A 22 CYS A 92 1555 1555 2.03 SSBOND 33 CYS C 23 CYS C 88 1555 1555 2.03 SSBOND 34 CYS F 22 CYS F 92 1555 1555 2.03 SSBOND 35 CYS I 23 CYS I 88 1555 1555 2.03 SSBOND 36 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 37 CYS J 98 CYS J 100A 1555 1555 2.03 SSBOND 38 CYS K 23 CYS K 87 1555 1555 2.04 SSBOND 39 CYS D 598 CYS D 604 1555 1555 2.02 SSBOND 40 CYS D 605 CYS P 501 1555 1555 2.03 SSBOND 41 CYS P 54 CYS P 74 1555 1555 2.04 SSBOND 42 CYS P 119 CYS P 205 1555 1555 2.03 SSBOND 43 CYS P 126 CYS P 196 1555 1555 2.03 SSBOND 44 CYS P 131 CYS P 157 1555 1555 2.03 SSBOND 45 CYS P 201 CYS P 433 1555 1555 2.02 SSBOND 46 CYS P 218 CYS P 247 1555 1555 2.03 SSBOND 47 CYS P 228 CYS P 239 1555 1555 2.03 SSBOND 48 CYS P 296 CYS P 331 1555 1555 2.02 SSBOND 49 CYS P 378 CYS P 445 1555 1555 2.03 SSBOND 50 CYS P 385 CYS P 418 1555 1555 2.03 SSBOND 51 CYS M 22 CYS M 92 1555 1555 2.03 SSBOND 52 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 53 CYS Q 22 CYS Q 92 1555 1555 2.04 SSBOND 54 CYS R 23 CYS R 88 1555 1555 2.04 SSBOND 55 CYS S 22 CYS S 92 1555 1555 2.03 SSBOND 56 CYS S 98 CYS S 100A 1555 1555 2.04 SSBOND 57 CYS T 23 CYS T 87 1555 1555 2.04 LINK ND2 ASN B 637 C1 NAG B 701 1555 1555 1.43 LINK ND2 ASN G 88 C1 NAG G 601 1555 1555 1.46 LINK ND2 ASN G 133 C1 NAG G 625 1555 1555 1.45 LINK ND2 ASN G 137 C1 NAG G 603 1555 1555 1.42 LINK ND2 ASN G 156 C1 NAG G 608 1555 1555 1.44 LINK ND2 ASN G 160 C1 NAG G 611 1555 1555 1.43 LINK ND2 ASN G 197 C1 NAG G 613 1555 1555 1.45 LINK ND2 ASN G 234 C1 NAG G 615 1555 1555 1.44 LINK ND2 ASN G 262 C1 NAG G 617 1555 1555 1.43 LINK ND2 ASN G 276 C1 NAG G 647 1555 1555 1.42 LINK ND2 ASN G 295 C1 NAG G 621 1555 1555 1.43 LINK ND2 ASN G 301 C1 NAG G 623 1555 1555 1.44 LINK ND2 ASN G 332 C1 NAG G 626 1555 1555 1.43 LINK ND2 ASN G 339 C1 NAG G 632 1555 1555 1.44 LINK ND2 ASN G 355 C1 NAG G 633 1555 1555 1.44 LINK ND2 ASN G 363 C1 NAG G 634 1555 1555 1.43 LINK ND2 ASN G 386 C1 NAG G 637 1555 1555 1.44 LINK ND2 ASN G 392 C1 NAG G 642 1555 1555 1.43 LINK ND2 ASN G 448 C1 NAG G 645 1555 1555 1.43 LINK ND2 ASN O 637 C1 NAG O 701 1555 1555 1.43 LINK ND2 ASN E 88 C1 NAG E 601 1555 1555 1.46 LINK ND2 ASN E 133 C1 NAG E 625 1555 1555 1.45 LINK ND2 ASN E 137 C1 NAG E 603 1555 1555 1.42 LINK ND2 ASN E 156 C1 NAG E 608 1555 1555 1.44 LINK ND2 ASN E 160 C1 NAG E 611 1555 1555 1.43 LINK ND2 ASN E 197 C1 NAG E 613 1555 1555 1.45 LINK ND2 ASN E 234 C1 NAG E 615 1555 1555 1.44 LINK ND2 ASN E 262 C1 NAG E 617 1555 1555 1.43 LINK ND2 ASN E 276 C1 NAG E 647 1555 1555 1.42 LINK ND2 ASN E 295 C1 NAG E 621 1555 1555 1.43 LINK ND2 ASN E 301 C1 NAG E 623 1555 1555 1.44 LINK ND2 ASN E 332 C1 NAG E 626 1555 1555 1.43 LINK ND2 ASN E 339 C1 NAG E 632 1555 1555 1.44 LINK ND2 ASN E 355 C1 NAG E 633 1555 1555 1.44 LINK ND2 ASN E 363 C1 NAG E 634 1555 1555 1.43 LINK ND2 ASN E 386 C1 NAG E 637 1555 1555 1.44 LINK ND2 ASN E 392 C1 NAG E 642 1555 1555 1.43 LINK ND2 ASN E 448 C1 NAG E 645 1555 1555 1.43 LINK ND2 ASN D 637 C1 NAG D 701 1555 1555 1.43 LINK ND2 ASN P 88 C1 NAG P 601 1555 1555 1.46 LINK ND2 ASN P 133 C1 NAG P 625 1555 1555 1.45 LINK ND2 ASN P 137 C1 NAG P 603 1555 1555 1.42 LINK ND2 ASN P 156 C1 NAG P 608 1555 1555 1.44 LINK ND2 ASN P 160 C1 NAG P 611 1555 1555 1.43 LINK ND2 ASN P 197 C1 NAG P 613 1555 1555 1.45 LINK ND2 ASN P 234 C1 NAG P 615 1555 1555 1.44 LINK ND2 ASN P 262 C1 NAG P 617 1555 1555 1.43 LINK ND2 ASN P 276 C1 NAG P 647 1555 1555 1.42 LINK ND2 ASN P 295 C1 NAG P 621 1555 1555 1.43 LINK ND2 ASN P 301 C1 NAG P 623 1555 1555 1.44 LINK ND2 ASN P 332 C1 NAG P 626 1555 1555 1.43 LINK ND2 ASN P 339 C1 NAG P 632 1555 1555 1.44 LINK ND2 ASN P 355 C1 NAG P 633 1555 1555 1.44 LINK ND2 ASN P 363 C1 NAG P 634 1555 1555 1.43 LINK ND2 ASN P 386 C1 NAG P 637 1555 1555 1.44 LINK ND2 ASN P 392 C1 NAG P 642 1555 1555 1.43 LINK ND2 ASN P 448 C1 NAG P 645 1555 1555 1.43 LINK O4 NAG G 601 C1 NAG G 602 1555 1555 1.44 LINK O4 NAG G 603 C1 NAG G 604 1555 1555 1.45 LINK O4 NAG G 604 C1 BMA G 605 1555 1555 1.44 LINK O3 BMA G 605 C1 MAN G 606 1555 1555 1.44 LINK O6 BMA G 605 C1 MAN G 607 1555 1555 1.45 LINK O4 NAG G 608 C1 NAG G 609 1555 1555 1.46 LINK O4 NAG G 609 C1 BMA G 610 1555 1555 1.44 LINK O4 NAG G 611 C1 NAG G 612 1555 1555 1.44 LINK O4 NAG G 613 C1 NAG G 614 1555 1555 1.45 LINK O4 NAG G 615 C1 NAG G 616 1555 1555 1.44 LINK O4 NAG G 617 C1 NAG G 618 1555 1555 1.46 LINK O4 NAG G 618 C1 BMA G 619 1555 1555 1.44 LINK O3 BMA G 619 C1 MAN G 620 1555 1555 1.44 LINK O4 NAG G 621 C1 NAG G 622 1555 1555 1.45 LINK O4 NAG G 623 C1 NAG G 624 1555 1555 1.45 LINK O4 NAG G 626 C1 NAG G 627 1555 1555 1.44 LINK O4 NAG G 627 C1 BMA G 628 1555 1555 1.43 LINK O3 BMA G 628 C1 MAN G 630 1555 1555 1.45 LINK O6 BMA G 628 C1 MAN G 629 1555 1555 1.44 LINK O2 MAN G 630 C1 MAN G 631 1555 1555 1.44 LINK O4 NAG G 634 C1 NAG G 635 1555 1555 1.44 LINK O4 NAG G 635 C1 BMA G 636 1555 1555 1.46 LINK O4 NAG G 637 C1 NAG G 638 1555 1555 1.45 LINK O4 NAG G 638 C1 BMA G 639 1555 1555 1.44 LINK O3 BMA G 639 C1 MAN G 640 1555 1555 1.44 LINK O6 BMA G 639 C1 MAN G 641 1555 1555 1.44 LINK O4 NAG G 642 C1 NAG G 643 1555 1555 1.44 LINK O4 NAG G 643 C1 BMA G 644 1555 1555 1.46 LINK O4 NAG G 645 C1 NAG G 646 1555 1555 1.45 LINK O4 NAG G 647 C1 NAG G 648 1555 1555 1.43 LINK O4 NAG G 648 C1 BMA G 649 1555 1555 1.44 LINK O3 BMA G 649 C1 MAN G 651 1555 1555 1.44 LINK O6 BMA G 649 C1 MAN G 650 1555 1555 1.44 LINK O4 NAG E 601 C1 NAG E 602 1555 1555 1.44 LINK O4 NAG E 603 C1 NAG E 604 1555 1555 1.45 LINK O4 NAG E 604 C1 BMA E 605 1555 1555 1.44 LINK O3 BMA E 605 C1 MAN E 606 1555 1555 1.44 LINK O6 BMA E 605 C1 MAN E 607 1555 1555 1.45 LINK O4 NAG E 608 C1 NAG E 609 1555 1555 1.46 LINK O4 NAG E 609 C1 BMA E 610 1555 1555 1.44 LINK O4 NAG E 611 C1 NAG E 612 1555 1555 1.44 LINK O4 NAG E 613 C1 NAG E 614 1555 1555 1.45 LINK O4 NAG E 615 C1 NAG E 616 1555 1555 1.45 LINK O4 NAG E 617 C1 NAG E 618 1555 1555 1.46 LINK O4 NAG E 618 C1 BMA E 619 1555 1555 1.44 LINK O3 BMA E 619 C1 MAN E 620 1555 1555 1.45 LINK O4 NAG E 621 C1 NAG E 622 1555 1555 1.45 LINK O4 NAG E 623 C1 NAG E 624 1555 1555 1.45 LINK O4 NAG E 626 C1 NAG E 627 1555 1555 1.44 LINK O4 NAG E 627 C1 BMA E 628 1555 1555 1.43 LINK O3 BMA E 628 C1 MAN E 630 1555 1555 1.45 LINK O6 BMA E 628 C1 MAN E 629 1555 1555 1.44 LINK O2 MAN E 630 C1 MAN E 631 1555 1555 1.44 LINK O4 NAG E 634 C1 NAG E 635 1555 1555 1.44 LINK O4 NAG E 635 C1 BMA E 636 1555 1555 1.46 LINK O4 NAG E 637 C1 NAG E 638 1555 1555 1.45 LINK O4 NAG E 638 C1 BMA E 639 1555 1555 1.44 LINK O3 BMA E 639 C1 MAN E 640 1555 1555 1.44 LINK O6 BMA E 639 C1 MAN E 641 1555 1555 1.44 LINK O4 NAG E 642 C1 NAG E 643 1555 1555 1.44 LINK O4 NAG E 643 C1 BMA E 644 1555 1555 1.46 LINK O4 NAG E 645 C1 NAG E 646 1555 1555 1.45 LINK O4 NAG E 647 C1 NAG E 648 1555 1555 1.43 LINK O4 NAG E 648 C1 BMA E 649 1555 1555 1.44 LINK O3 BMA E 649 C1 MAN E 651 1555 1555 1.44 LINK O6 BMA E 649 C1 MAN E 650 1555 1555 1.44 LINK O4 NAG P 601 C1 NAG P 602 1555 1555 1.44 LINK O4 NAG P 603 C1 NAG P 604 1555 1555 1.45 LINK O4 NAG P 604 C1 BMA P 605 1555 1555 1.44 LINK O3 BMA P 605 C1 MAN P 606 1555 1555 1.44 LINK O6 BMA P 605 C1 MAN P 607 1555 1555 1.45 LINK O4 NAG P 608 C1 NAG P 609 1555 1555 1.46 LINK O4 NAG P 609 C1 BMA P 610 1555 1555 1.44 LINK O4 NAG P 611 C1 NAG P 612 1555 1555 1.45 LINK O4 NAG P 613 C1 NAG P 614 1555 1555 1.45 LINK O4 NAG P 615 C1 NAG P 616 1555 1555 1.45 LINK O4 NAG P 617 C1 NAG P 618 1555 1555 1.46 LINK O4 NAG P 618 C1 BMA P 619 1555 1555 1.44 LINK O3 BMA P 619 C1 MAN P 620 1555 1555 1.44 LINK O4 NAG P 621 C1 NAG P 622 1555 1555 1.45 LINK O4 NAG P 623 C1 NAG P 624 1555 1555 1.45 LINK O4 NAG P 626 C1 NAG P 627 1555 1555 1.44 LINK O4 NAG P 627 C1 BMA P 628 1555 1555 1.43 LINK O3 BMA P 628 C1 MAN P 630 1555 1555 1.45 LINK O6 BMA P 628 C1 MAN P 629 1555 1555 1.44 LINK O2 MAN P 630 C1 MAN P 631 1555 1555 1.44 LINK O4 NAG P 634 C1 NAG P 635 1555 1555 1.44 LINK O4 NAG P 635 C1 BMA P 636 1555 1555 1.46 LINK O4 NAG P 637 C1 NAG P 638 1555 1555 1.45 LINK O4 NAG P 638 C1 BMA P 639 1555 1555 1.44 LINK O3 BMA P 639 C1 MAN P 640 1555 1555 1.44 LINK O6 BMA P 639 C1 MAN P 641 1555 1555 1.44 LINK O4 NAG P 642 C1 NAG P 643 1555 1555 1.44 LINK O4 NAG P 643 C1 BMA P 644 1555 1555 1.46 LINK O4 NAG P 645 C1 NAG P 646 1555 1555 1.45 LINK O4 NAG P 647 C1 NAG P 648 1555 1555 1.43 LINK O4 NAG P 648 C1 BMA P 649 1555 1555 1.44 LINK O3 BMA P 649 C1 MAN P 651 1555 1555 1.44 LINK O6 BMA P 649 C1 MAN P 650 1555 1555 1.44 CISPEP 1 THR L 7 PRO L 8 0 -2.79 CISPEP 2 ILE L 94 PRO L 95 0 5.53 CISPEP 3 THR C 7 PRO C 8 0 -2.75 CISPEP 4 ILE C 94 PRO C 95 0 5.66 CISPEP 5 THR N 7 PRO N 8 0 -2.77 CISPEP 6 ILE N 94 PRO N 95 0 5.56 SITE 1 AC1 1 ASN B 637 SITE 1 AC2 1 ASN D 637 SITE 1 AC3 4 ASP A 54 GLU E 87 ASN E 88 SER O 528 SITE 1 AC4 2 ASN E 133 ARG E 178 SITE 1 AC5 10 ASN E 137 THR E 139 GLY F 55 ASP F 56 SITE 2 AC5 10 ASN F 58 ARG F 99 PHE F 100K THR F 100L SITE 3 AC5 10 ASP I 92 THR I 95B SITE 1 AC6 4 THR E 135 ASN E 156 TYR E 173 ASP E 321A SITE 1 AC7 1 ASN E 160 SITE 1 AC8 2 ARG E 192 ASN E 197 SITE 1 AC9 2 ASN E 234 GLU E 275 SITE 1 AD1 7 GLU E 211 PRO E 212 ASN E 262 ASN E 377 SITE 2 AD1 7 VAL E 446 SER E 447 NAG E 645 SITE 1 AD2 5 ASN E 276 ASP K 49 THR K 50 SER K 51 SITE 2 AD2 5 PHE K 90 SITE 1 AD3 3 ASN E 295 SER E 334 ARG E 444 SITE 1 AD4 1 ASN E 301 SITE 1 AD5 11 ASN E 295 HIS E 330 ASN E 332 ARG F 100 SITE 2 AD5 11 ILE F 100A GLY F 100C VAL F 100E ASN I 50 SITE 3 AD5 11 ASN I 51 PRO I 66 GLY I 67 SITE 1 AD6 1 ASN E 339 SITE 1 AD7 1 ASN E 355 SITE 1 AD8 4 ASN E 363 ASN E 386 NAG E 637 NAG E 638 SITE 1 AD9 4 ASP E 141 ASN E 386 NAG E 634 NAG E 635 SITE 1 AE1 2 SER E 388 ASN E 392 SITE 1 AE2 3 ASN E 262 ASN E 448 NAG E 617 SITE 1 AE3 4 SER B 528 GLU G 87 ASN G 88 ASP H 54 SITE 1 AE4 2 ASN G 133 ARG G 178 SITE 1 AE5 10 ASN G 137 THR G 139 GLY m 55 ASP m 56 SITE 2 AE5 10 ASN m 58 ARG m 99 PHE m 100K THR m 100L SITE 3 AE5 10 ASP n 92 THR n 95B SITE 1 AE6 4 THR G 135 ASN G 156 TYR G 173 ASP G 321A SITE 1 AE7 1 ASN G 160 SITE 1 AE8 2 ARG G 192 ASN G 197 SITE 1 AE9 2 ASN G 234 GLU G 275 SITE 1 AF1 7 GLU G 211 PRO G 212 ASN G 262 ASN G 377 SITE 2 AF1 7 VAL G 446 SER G 447 NAG G 645 SITE 1 AF2 5 ASN G 276 ASP r 49 THR r 50 SER r 51 SITE 2 AF2 5 PHE r 90 SITE 1 AF3 3 ASN G 295 SER G 334 ARG G 444 SITE 1 AF4 1 ASN G 301 SITE 1 AF5 11 ASN G 295 HIS G 330 ASN G 332 ARG m 100 SITE 2 AF5 11 ILE m 100A GLY m 100C VAL m 100E ASN n 50 SITE 3 AF5 11 ASN n 51 PRO n 66 GLY n 67 SITE 1 AF6 1 ASN G 339 SITE 1 AF7 1 ASN G 355 SITE 1 AF8 4 ASN G 363 ASN G 386 NAG G 637 NAG G 638 SITE 1 AF9 4 ASP G 141 ASN G 386 NAG G 634 NAG G 635 SITE 1 AG1 2 SER G 388 ASN G 392 SITE 1 AG2 3 ASN G 262 ASN G 448 NAG G 617 SITE 1 AG3 1 ASN O 637 SITE 1 AG4 4 SER D 528 ASP M 54 GLU P 87 ASN P 88 SITE 1 AG5 2 ASN P 133 ARG P 178 SITE 1 AG6 10 ASN P 137 THR P 139 GLY Q 55 ASP Q 56 SITE 2 AG6 10 ASN Q 58 ARG Q 99 PHE Q 100K THR Q 100L SITE 3 AG6 10 ASP R 92 THR R 95B SITE 1 AG7 4 THR P 135 ASN P 156 TYR P 173 ASP P 321A SITE 1 AG8 1 ASN P 160 SITE 1 AG9 2 ARG P 192 ASN P 197 SITE 1 AH1 2 ASN P 234 GLU P 275 SITE 1 AH2 7 GLU P 211 PRO P 212 ASN P 262 ASN P 377 SITE 2 AH2 7 VAL P 446 SER P 447 NAG P 645 SITE 1 AH3 5 ASN P 276 ASP T 49 THR T 50 SER T 51 SITE 2 AH3 5 PHE T 90 SITE 1 AH4 3 ASN P 295 SER P 334 ARG P 444 SITE 1 AH5 1 ASN P 301 SITE 1 AH6 11 ASN P 295 HIS P 330 ASN P 332 ARG Q 100 SITE 2 AH6 11 ILE Q 100A GLY Q 100C VAL Q 100E ASN R 50 SITE 3 AH6 11 ASN R 51 PRO R 66 GLY R 67 SITE 1 AH7 1 ASN P 339 SITE 1 AH8 1 ASN P 355 SITE 1 AH9 4 ASN P 363 ASN P 386 NAG P 637 NAG P 638 SITE 1 AI1 4 ASP P 141 ASN P 386 NAG P 634 NAG P 635 SITE 1 AI2 2 SER P 388 ASN P 392 SITE 1 AI3 3 ASN P 262 ASN P 448 NAG P 617 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000