HEADER VIRAL PROTEIN 24-MAY-21 7EW5 TITLE IMMUNE COMPLEX OF HPV6 L1 PENTAMER AND NEUTRALIZING ANTIBODY 13H5 COMPND MOL_ID: 1; COMPND 2 MOLECULE: MAJOR CAPSID PROTEIN L1; COMPND 3 CHAIN: A, D, G, J, M, P, S, V, Y, b; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: HEAVY CHAIN OF 13H5; COMPND 7 CHAIN: B, E, H, K, N, g, Q, T, W, Z; COMPND 8 MOL_ID: 3; COMPND 9 MOLECULE: LIGHT CHAIN OF 13H5; COMPND 10 CHAIN: C, F, I, L, O, j, R, U, X, a SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN PAPILLOMAVIRUS TYPE 6; SOURCE 3 ORGANISM_TAXID: 31552; SOURCE 4 GENE: L1; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 9 ORGANISM_TAXID: 10090; SOURCE 10 MOL_ID: 3; SOURCE 11 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 12 ORGANISM_TAXID: 10090 KEYWDS IMMUNE COMPLEX, VIRAL PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR Z.P.WANG,D.N.WANG,Y.GU,S.W.LI JRNL AUTH Z.P.WANG,D.N.WANG,Y.GU,S.W.LI JRNL TITL STRUCTURE OF HPV6 L1 PENTAMER IN COMPLEX WITH NEUTRALIZING JRNL TITL 2 ANTIBODY 13H5 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.61 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX 1.15.2_3472 REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : ML REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.61 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 49.02 REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.350 REMARK 3 COMPLETENESS FOR RANGE (%) : 99.5 REMARK 3 NUMBER OF REFLECTIONS : 133619 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : 0.254 REMARK 3 R VALUE (WORKING SET) : 0.252 REMARK 3 FREE R VALUE : 0.293 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.030 REMARK 3 FREE R VALUE TEST SET COUNT : 6718 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 1 49.0190 - 11.1610 0.98 4307 221 0.2451 0.2451 REMARK 3 2 11.1610 - 8.8760 1.00 4293 216 0.1766 0.1934 REMARK 3 3 8.8760 - 7.7590 1.00 4286 223 0.1850 0.2278 REMARK 3 4 7.7590 - 7.0518 1.00 4257 230 0.2243 0.2648 REMARK 3 5 7.0518 - 6.5476 1.00 4261 232 0.2205 0.2853 REMARK 3 6 6.5476 - 6.1624 1.00 4269 226 0.2357 0.2765 REMARK 3 7 6.1624 - 5.8543 1.00 4244 215 0.2358 0.2717 REMARK 3 8 5.8543 - 5.5998 1.00 4264 210 0.2425 0.2913 REMARK 3 9 5.5998 - 5.3845 1.00 4250 237 0.2260 0.2829 REMARK 3 10 5.3845 - 5.1989 1.00 4230 212 0.2255 0.2756 REMARK 3 11 5.1989 - 5.0365 1.00 4272 211 0.2135 0.2602 REMARK 3 12 5.0365 - 4.8927 1.00 4247 232 0.2189 0.2778 REMARK 3 13 4.8927 - 4.7640 1.00 4234 244 0.2159 0.2310 REMARK 3 14 4.7640 - 4.6479 1.00 4212 201 0.2179 0.2828 REMARK 3 15 4.6479 - 4.5423 1.00 4254 242 0.2396 0.2856 REMARK 3 16 4.5423 - 4.4457 1.00 4216 255 0.2374 0.2861 REMARK 3 17 4.4457 - 4.3568 1.00 4212 215 0.2730 0.3075 REMARK 3 18 4.3568 - 4.2746 1.00 4278 210 0.2716 0.3212 REMARK 3 19 4.2746 - 4.1983 1.00 4241 198 0.2760 0.3320 REMARK 3 20 4.1983 - 4.1272 1.00 4225 213 0.2895 0.3264 REMARK 3 21 4.1272 - 4.0607 1.00 4237 229 0.3053 0.3671 REMARK 3 22 4.0607 - 3.9982 1.00 4245 224 0.3101 0.3580 REMARK 3 23 3.9982 - 3.9395 1.00 4207 226 0.3242 0.3629 REMARK 3 24 3.9395 - 3.8840 1.00 4236 225 0.3226 0.3836 REMARK 3 25 3.8840 - 3.8315 1.00 4239 250 0.3162 0.3798 REMARK 3 26 3.8315 - 3.7818 1.00 4200 244 0.3072 0.3476 REMARK 3 27 3.7818 - 3.7345 1.00 4232 218 0.3190 0.3326 REMARK 3 28 3.7345 - 3.6895 1.00 4264 200 0.3398 0.3952 REMARK 3 29 3.6895 - 3.6467 1.00 4216 240 0.3524 0.3771 REMARK 3 30 3.6467 - 3.6060 0.89 3773 219 0.3388 0.3495 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL REMARK 3 SOLVENT RADIUS : 1.11 REMARK 3 SHRINKAGE RADIUS : 0.90 REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.550 REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 30.820 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 85.43 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : NULL NULL REMARK 3 ANGLE : NULL NULL REMARK 3 CHIRALITY : NULL NULL REMARK 3 PLANARITY : NULL NULL REMARK 3 DIHEDRAL : NULL NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 189 REMARK 3 TLS GROUP : 1 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 12 THROUGH 77 ) REMARK 3 ORIGIN FOR THE GROUP (A): -78.4193 17.5281 -87.8262 REMARK 3 T TENSOR REMARK 3 T11: 0.3641 T22: 0.4588 REMARK 3 T33: 0.4949 T12: -0.0485 REMARK 3 T13: 0.0421 T23: -0.2021 REMARK 3 L TENSOR REMARK 3 L11: 0.0410 L22: 0.3125 REMARK 3 L33: 0.2905 L12: 0.0576 REMARK 3 L13: 0.0075 L23: -0.0886 REMARK 3 S TENSOR REMARK 3 S11: -0.2423 S12: 0.3376 S13: -0.3427 REMARK 3 S21: -0.3232 S22: -0.2593 S23: 0.0788 REMARK 3 S31: 0.2290 S32: -0.2407 S33: -0.4571 REMARK 3 TLS GROUP : 2 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 78 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): -78.4324 22.1104 -89.2348 REMARK 3 T TENSOR REMARK 3 T11: 0.2159 T22: 0.3673 REMARK 3 T33: 0.6477 T12: 0.1652 REMARK 3 T13: 0.0710 T23: -0.5308 REMARK 3 L TENSOR REMARK 3 L11: 0.3581 L22: 0.2006 REMARK 3 L33: 0.1581 L12: -0.1386 REMARK 3 L13: -0.1950 L23: 0.0032 REMARK 3 S TENSOR REMARK 3 S11: -0.0317 S12: 0.7600 S13: -0.1514 REMARK 3 S21: -0.1234 S22: -0.0613 S23: -0.0983 REMARK 3 S31: 0.0894 S32: -0.2749 S33: -0.3634 REMARK 3 TLS GROUP : 3 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 116 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): -55.2582 34.8641 -78.5250 REMARK 3 T TENSOR REMARK 3 T11: 0.3113 T22: 0.5035 REMARK 3 T33: 0.5092 T12: 0.0973 REMARK 3 T13: 0.1458 T23: -0.0417 REMARK 3 L TENSOR REMARK 3 L11: 0.1170 L22: 0.0744 REMARK 3 L33: 0.1899 L12: 0.1283 REMARK 3 L13: -0.1330 L23: -0.1181 REMARK 3 S TENSOR REMARK 3 S11: 0.0906 S12: 0.0593 S13: 0.0817 REMARK 3 S21: -0.1015 S22: -0.1358 S23: -0.0292 REMARK 3 S31: -0.2711 S32: 0.5628 S33: -0.0320 REMARK 3 TLS GROUP : 4 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 171 THROUGH 295 ) REMARK 3 ORIGIN FOR THE GROUP (A): -57.7337 35.9782 -82.0123 REMARK 3 T TENSOR REMARK 3 T11: 0.4690 T22: 0.4256 REMARK 3 T33: 0.3734 T12: -0.0419 REMARK 3 T13: 0.1791 T23: -0.2219 REMARK 3 L TENSOR REMARK 3 L11: 0.5064 L22: 0.2561 REMARK 3 L33: 0.4449 L12: -0.3142 REMARK 3 L13: 0.2587 L23: -0.0727 REMARK 3 S TENSOR REMARK 3 S11: 0.0106 S12: 0.5302 S13: 0.0071 REMARK 3 S21: -0.4186 S22: -0.0838 S23: -0.3238 REMARK 3 S31: -0.0850 S32: 0.2206 S33: -0.6203 REMARK 3 TLS GROUP : 5 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 296 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -78.5304 25.3626 -80.0405 REMARK 3 T TENSOR REMARK 3 T11: 0.3058 T22: 0.4928 REMARK 3 T33: 0.2808 T12: 0.0283 REMARK 3 T13: 0.0941 T23: -0.2781 REMARK 3 L TENSOR REMARK 3 L11: 0.3071 L22: 0.3300 REMARK 3 L33: 0.0734 L12: 0.2683 REMARK 3 L13: -0.1578 L23: -0.1460 REMARK 3 S TENSOR REMARK 3 S11: 0.0024 S12: 0.0718 S13: -0.4285 REMARK 3 S21: 0.0660 S22: -0.2507 S23: -0.1897 REMARK 3 S31: 0.1244 S32: 0.0310 S33: -0.3816 REMARK 3 TLS GROUP : 6 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -72.9089 8.2228-108.7874 REMARK 3 T TENSOR REMARK 3 T11: 1.2260 T22: 0.6817 REMARK 3 T33: 0.9595 T12: -0.2527 REMARK 3 T13: -0.1695 T23: -0.2928 REMARK 3 L TENSOR REMARK 3 L11: 0.0035 L22: 0.0112 REMARK 3 L33: 0.0065 L12: 0.0022 REMARK 3 L13: -0.0004 L23: 0.0085 REMARK 3 S TENSOR REMARK 3 S11: 0.0461 S12: -0.0576 S13: 0.0243 REMARK 3 S21: -0.0462 S22: 0.0980 S23: -0.0726 REMARK 3 S31: -0.0118 S32: 0.0335 S33: 0.0000 REMARK 3 TLS GROUP : 7 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): -86.6624 17.8808 -90.7751 REMARK 3 T TENSOR REMARK 3 T11: 0.8062 T22: 0.6137 REMARK 3 T33: 0.6356 T12: -0.1275 REMARK 3 T13: -0.0398 T23: -0.3916 REMARK 3 L TENSOR REMARK 3 L11: 0.0143 L22: 0.0152 REMARK 3 L33: 0.0681 L12: 0.0117 REMARK 3 L13: 0.0178 L23: 0.0530 REMARK 3 S TENSOR REMARK 3 S11: 0.1161 S12: 0.0435 S13: 0.0419 REMARK 3 S21: -0.0762 S22: -0.0285 S23: -0.0546 REMARK 3 S31: -0.0559 S32: -0.1301 S33: 0.1532 REMARK 3 TLS GROUP : 8 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 12 THROUGH 77 ) REMARK 3 ORIGIN FOR THE GROUP (A): -53.1920 44.0800-107.6894 REMARK 3 T TENSOR REMARK 3 T11: 0.8566 T22: 0.5829 REMARK 3 T33: 0.3156 T12: 0.0320 REMARK 3 T13: 0.1266 T23: -0.1034 REMARK 3 L TENSOR REMARK 3 L11: 0.2012 L22: 0.0712 REMARK 3 L33: 0.2020 L12: 0.0550 REMARK 3 L13: 0.0399 L23: 0.1364 REMARK 3 S TENSOR REMARK 3 S11: 0.1816 S12: 0.3473 S13: -0.2140 REMARK 3 S21: -0.1444 S22: 0.0331 S23: 0.0256 REMARK 3 S31: 0.1006 S32: 0.1849 S33: 0.1018 REMARK 3 TLS GROUP : 9 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 78 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): -53.0023 56.4490 -93.1762 REMARK 3 T TENSOR REMARK 3 T11: 0.7640 T22: 0.5183 REMARK 3 T33: 0.3107 T12: 0.0410 REMARK 3 T13: 0.1546 T23: -0.0752 REMARK 3 L TENSOR REMARK 3 L11: 0.3641 L22: 0.1054 REMARK 3 L33: 0.5987 L12: -0.0796 REMARK 3 L13: 0.4694 L23: -0.1223 REMARK 3 S TENSOR REMARK 3 S11: -0.4010 S12: 0.1517 S13: 0.3131 REMARK 3 S21: -0.1933 S22: -0.0714 S23: 0.0020 REMARK 3 S31: -0.3089 S32: -0.0669 S33: -0.5391 REMARK 3 TLS GROUP : 10 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 171 THROUGH 324 ) REMARK 3 ORIGIN FOR THE GROUP (A): -55.5240 60.8250 -91.7499 REMARK 3 T TENSOR REMARK 3 T11: 0.6595 T22: 0.5186 REMARK 3 T33: 0.2565 T12: -0.0063 REMARK 3 T13: 0.1164 T23: 0.0478 REMARK 3 L TENSOR REMARK 3 L11: -0.0130 L22: 0.1259 REMARK 3 L33: -0.0029 L12: -0.0598 REMARK 3 L13: 0.0386 L23: -0.0374 REMARK 3 S TENSOR REMARK 3 S11: -0.0508 S12: 0.0981 S13: 0.2837 REMARK 3 S21: -0.5525 S22: 0.0306 S23: -0.2791 REMARK 3 S31: -0.5748 S32: 0.0528 S33: -0.0215 REMARK 3 TLS GROUP : 11 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 325 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -51.9700 37.7052 -88.7892 REMARK 3 T TENSOR REMARK 3 T11: 0.5163 T22: 0.4866 REMARK 3 T33: 0.2837 T12: 0.1213 REMARK 3 T13: 0.0854 T23: -0.0284 REMARK 3 L TENSOR REMARK 3 L11: 0.0708 L22: 0.0674 REMARK 3 L33: 0.2026 L12: 0.0977 REMARK 3 L13: 0.0583 L23: 0.0134 REMARK 3 S TENSOR REMARK 3 S11: 0.1600 S12: 0.1480 S13: 0.0389 REMARK 3 S21: -0.6144 S22: 0.0600 S23: -0.2525 REMARK 3 S31: -0.2265 S32: 0.0758 S33: 0.0276 REMARK 3 TLS GROUP : 12 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -51.3386 56.3075-127.8224 REMARK 3 T TENSOR REMARK 3 T11: 1.2180 T22: 1.0210 REMARK 3 T33: 0.5636 T12: 0.1055 REMARK 3 T13: 0.0730 T23: -0.0213 REMARK 3 L TENSOR REMARK 3 L11: 0.0055 L22: 0.0112 REMARK 3 L33: 0.0078 L12: 0.0066 REMARK 3 L13: -0.0015 L23: 0.0061 REMARK 3 S TENSOR REMARK 3 S11: -0.1654 S12: -0.0471 S13: -0.0633 REMARK 3 S21: 0.0441 S22: -0.1695 S23: -0.0573 REMARK 3 S31: 0.0594 S32: 0.0590 S33: 0.0000 REMARK 3 TLS GROUP : 13 REMARK 3 SELECTION: CHAIN 'D' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): -59.0261 39.0866-111.9544 REMARK 3 T TENSOR REMARK 3 T11: 1.2535 T22: 0.9155 REMARK 3 T33: 0.4758 T12: 0.0843 REMARK 3 T13: 0.0419 T23: -0.1702 REMARK 3 L TENSOR REMARK 3 L11: 0.0301 L22: 0.0404 REMARK 3 L33: 0.0379 L12: -0.0365 REMARK 3 L13: 0.0003 L23: -0.0165 REMARK 3 S TENSOR REMARK 3 S11: 0.3323 S12: 0.0926 S13: 0.0994 REMARK 3 S21: -0.2906 S22: -0.0499 S23: -0.0175 REMARK 3 S31: 0.1220 S32: 0.1429 S33: 0.0000 REMARK 3 TLS GROUP : 14 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 12 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): -68.4323 81.5483-100.4384 REMARK 3 T TENSOR REMARK 3 T11: 0.8702 T22: 0.4253 REMARK 3 T33: 0.3502 T12: -0.0790 REMARK 3 T13: 0.0800 T23: 0.1558 REMARK 3 L TENSOR REMARK 3 L11: 0.1705 L22: 0.3035 REMARK 3 L33: 0.1674 L12: 0.1537 REMARK 3 L13: -0.1199 L23: -0.2530 REMARK 3 S TENSOR REMARK 3 S11: 0.1579 S12: 0.0908 S13: -0.0525 REMARK 3 S21: -0.3845 S22: -0.1307 S23: -0.0456 REMARK 3 S31: -0.2671 S32: 0.1999 S33: 0.2141 REMARK 3 TLS GROUP : 15 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): -66.5115 71.4638 -68.4544 REMARK 3 T TENSOR REMARK 3 T11: 1.0824 T22: 0.1565 REMARK 3 T33: 0.3302 T12: 0.0470 REMARK 3 T13: 0.0799 T23: 0.1235 REMARK 3 L TENSOR REMARK 3 L11: 0.2816 L22: 0.0446 REMARK 3 L33: 0.0826 L12: -0.0922 REMARK 3 L13: -0.1035 L23: 0.0661 REMARK 3 S TENSOR REMARK 3 S11: -0.3186 S12: 0.0745 S13: 0.2181 REMARK 3 S21: 0.0934 S22: 0.0892 S23: -0.1901 REMARK 3 S31: 0.1421 S32: -0.1267 S33: 0.0531 REMARK 3 TLS GROUP : 16 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 150 THROUGH 198 ) REMARK 3 ORIGIN FOR THE GROUP (A): -75.6530 88.4221 -76.2809 REMARK 3 T TENSOR REMARK 3 T11: 0.6858 T22: 0.3072 REMARK 3 T33: 0.5000 T12: 0.0589 REMARK 3 T13: -0.0067 T23: 0.0751 REMARK 3 L TENSOR REMARK 3 L11: 0.1722 L22: 0.0170 REMARK 3 L33: -0.0008 L12: 0.0298 REMARK 3 L13: -0.0301 L23: -0.0018 REMARK 3 S TENSOR REMARK 3 S11: 0.0133 S12: -0.1963 S13: 0.2368 REMARK 3 S21: -0.1101 S22: 0.2638 S23: -0.0596 REMARK 3 S31: -0.2423 S32: -0.0613 S33: 0.0029 REMARK 3 TLS GROUP : 17 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 199 THROUGH 266 ) REMARK 3 ORIGIN FOR THE GROUP (A): -75.0958 78.7459 -75.5480 REMARK 3 T TENSOR REMARK 3 T11: 0.6675 T22: 0.4487 REMARK 3 T33: 0.4373 T12: -0.0314 REMARK 3 T13: -0.0179 T23: 0.0562 REMARK 3 L TENSOR REMARK 3 L11: 0.0734 L22: 0.1063 REMARK 3 L33: 0.0329 L12: -0.1147 REMARK 3 L13: -0.0414 L23: 0.0744 REMARK 3 S TENSOR REMARK 3 S11: -0.0855 S12: 0.1049 S13: 0.1465 REMARK 3 S21: 0.0357 S22: -0.1371 S23: -0.2194 REMARK 3 S31: -0.0878 S32: -0.2981 S33: -0.0001 REMARK 3 TLS GROUP : 18 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 267 THROUGH 313 ) REMARK 3 ORIGIN FOR THE GROUP (A): -76.1005 71.2741 -81.8459 REMARK 3 T TENSOR REMARK 3 T11: 0.6037 T22: 0.3072 REMARK 3 T33: 0.4625 T12: 0.0181 REMARK 3 T13: -0.0069 T23: 0.0615 REMARK 3 L TENSOR REMARK 3 L11: 0.5884 L22: 0.0482 REMARK 3 L33: 0.2053 L12: -0.1455 REMARK 3 L13: 0.0622 L23: 0.1170 REMARK 3 S TENSOR REMARK 3 S11: 0.0858 S12: 0.2178 S13: 0.1792 REMARK 3 S21: 0.0525 S22: -0.1371 S23: 0.4565 REMARK 3 S31: -0.2143 S32: -0.0384 S33: -0.0029 REMARK 3 TLS GROUP : 19 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 314 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -58.0899 74.2842 -91.6920 REMARK 3 T TENSOR REMARK 3 T11: 0.6507 T22: 0.4262 REMARK 3 T33: 0.3510 T12: 0.0230 REMARK 3 T13: 0.0119 T23: 0.0771 REMARK 3 L TENSOR REMARK 3 L11: 0.1284 L22: 0.1830 REMARK 3 L33: 0.1528 L12: 0.1058 REMARK 3 L13: -0.1608 L23: -0.0393 REMARK 3 S TENSOR REMARK 3 S11: -0.0226 S12: 0.1994 S13: -0.0691 REMARK 3 S21: -0.4451 S22: 0.0440 S23: -0.1185 REMARK 3 S31: 0.0205 S32: 0.2143 S33: 0.0101 REMARK 3 TLS GROUP : 20 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -83.4008 98.1794-108.9524 REMARK 3 T TENSOR REMARK 3 T11: 1.3454 T22: 0.7869 REMARK 3 T33: 0.2837 T12: -0.0250 REMARK 3 T13: -0.2334 T23: 0.1920 REMARK 3 L TENSOR REMARK 3 L11: 0.0610 L22: 0.3529 REMARK 3 L33: 0.0646 L12: -0.1108 REMARK 3 L13: -0.0412 L23: 0.1569 REMARK 3 S TENSOR REMARK 3 S11: 0.0198 S12: -0.0713 S13: 0.0816 REMARK 3 S21: 0.1860 S22: 0.1861 S23: -0.0921 REMARK 3 S31: -0.1263 S32: -0.0519 S33: 0.0811 REMARK 3 TLS GROUP : 21 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): -68.3469 78.6407-108.6823 REMARK 3 T TENSOR REMARK 3 T11: 1.0447 T22: 0.7457 REMARK 3 T33: 0.4147 T12: 0.1251 REMARK 3 T13: 0.1208 T23: 0.1588 REMARK 3 L TENSOR REMARK 3 L11: 0.0045 L22: 0.0587 REMARK 3 L33: 0.0040 L12: -0.0390 REMARK 3 L13: -0.0058 L23: 0.0009 REMARK 3 S TENSOR REMARK 3 S11: 0.0349 S12: 0.2401 S13: -0.0207 REMARK 3 S21: -0.1818 S22: -0.0206 S23: -0.1135 REMARK 3 S31: 0.0381 S32: -0.0032 S33: 0.0013 REMARK 3 TLS GROUP : 22 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 12 THROUGH 77 ) REMARK 3 ORIGIN FOR THE GROUP (A):-101.2048 80.2184 -76.8580 REMARK 3 T TENSOR REMARK 3 T11: 0.7614 T22: 0.3926 REMARK 3 T33: 0.4916 T12: 0.1276 REMARK 3 T13: -0.1262 T23: 0.1330 REMARK 3 L TENSOR REMARK 3 L11: 0.0643 L22: 0.1616 REMARK 3 L33: 0.1372 L12: -0.0659 REMARK 3 L13: -0.0714 L23: 0.0796 REMARK 3 S TENSOR REMARK 3 S11: 0.2544 S12: 0.1445 S13: -0.0530 REMARK 3 S21: -0.1293 S22: 0.1272 S23: 0.0972 REMARK 3 S31: -0.1113 S32: -0.1718 S33: 0.1208 REMARK 3 TLS GROUP : 23 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 78 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): -99.8001 75.9113 -78.4919 REMARK 3 T TENSOR REMARK 3 T11: 0.5772 T22: -0.0271 REMARK 3 T33: 0.3778 T12: 0.3422 REMARK 3 T13: -0.0516 T23: -0.0901 REMARK 3 L TENSOR REMARK 3 L11: 0.3263 L22: 0.3270 REMARK 3 L33: 0.4702 L12: 0.0935 REMARK 3 L13: -0.1983 L23: 0.1059 REMARK 3 S TENSOR REMARK 3 S11: 0.0815 S12: 0.5453 S13: 0.1091 REMARK 3 S21: 0.0534 S22: 0.0204 S23: 0.2208 REMARK 3 S31: 0.0153 S32: -0.3625 S33: -0.0239 REMARK 3 TLS GROUP : 24 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): -79.8024 60.6533 -58.3027 REMARK 3 T TENSOR REMARK 3 T11: 0.5346 T22: 0.2391 REMARK 3 T33: 0.6004 T12: 0.0081 REMARK 3 T13: 0.0768 T23: -0.0201 REMARK 3 L TENSOR REMARK 3 L11: 0.0831 L22: 0.0234 REMARK 3 L33: 0.0923 L12: 0.0518 REMARK 3 L13: -0.1088 L23: -0.0640 REMARK 3 S TENSOR REMARK 3 S11: 0.0666 S12: -0.1037 S13: -0.0047 REMARK 3 S21: -0.1932 S22: -0.2411 S23: -0.0190 REMARK 3 S31: -0.2727 S32: -0.2159 S33: -0.0046 REMARK 3 TLS GROUP : 25 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 150 THROUGH 217 ) REMARK 3 ORIGIN FOR THE GROUP (A): -97.1593 63.9781 -55.9145 REMARK 3 T TENSOR REMARK 3 T11: 0.4103 T22: 0.3626 REMARK 3 T33: 0.3065 T12: 0.0569 REMARK 3 T13: 0.0336 T23: 0.0073 REMARK 3 L TENSOR REMARK 3 L11: 0.0078 L22: 0.0429 REMARK 3 L33: 0.0766 L12: 0.0234 REMARK 3 L13: 0.0328 L23: 0.0630 REMARK 3 S TENSOR REMARK 3 S11: -0.0747 S12: -0.2765 S13: 0.1004 REMARK 3 S21: 0.1965 S22: -0.1790 S23: 0.1937 REMARK 3 S31: 0.4384 S32: -0.3219 S33: -0.0017 REMARK 3 TLS GROUP : 26 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 218 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -89.8769 66.7082 -69.3940 REMARK 3 T TENSOR REMARK 3 T11: 0.5583 T22: 0.4037 REMARK 3 T33: 0.4672 T12: 0.0669 REMARK 3 T13: -0.1064 T23: -0.0142 REMARK 3 L TENSOR REMARK 3 L11: 0.2180 L22: 0.0577 REMARK 3 L33: 0.3927 L12: -0.0274 REMARK 3 L13: -0.2296 L23: -0.2342 REMARK 3 S TENSOR REMARK 3 S11: -0.1245 S12: -0.1216 S13: 0.0015 REMARK 3 S21: -0.1683 S22: 0.0430 S23: -0.0037 REMARK 3 S31: -0.0604 S32: -0.1425 S33: -0.0000 REMARK 3 TLS GROUP : 27 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A):-124.3934 76.3464 -77.9863 REMARK 3 T TENSOR REMARK 3 T11: 0.5111 T22: 1.0623 REMARK 3 T33: 0.6724 T12: -0.0846 REMARK 3 T13: -0.1098 T23: -0.0219 REMARK 3 L TENSOR REMARK 3 L11: 0.0086 L22: 0.0016 REMARK 3 L33: 0.0125 L12: 0.0094 REMARK 3 L13: -0.0087 L23: -0.0050 REMARK 3 S TENSOR REMARK 3 S11: 0.0077 S12: 0.0387 S13: -0.0408 REMARK 3 S21: 0.1318 S22: 0.0716 S23: 0.0306 REMARK 3 S31: -0.0605 S32: 0.0682 S33: 0.0000 REMARK 3 TLS GROUP : 28 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A):-101.5972 82.0440 -85.4779 REMARK 3 T TENSOR REMARK 3 T11: 0.7482 T22: 0.6208 REMARK 3 T33: 0.6104 T12: 0.1996 REMARK 3 T13: -0.0172 T23: -0.0937 REMARK 3 L TENSOR REMARK 3 L11: 0.1073 L22: 0.0223 REMARK 3 L33: 0.0469 L12: 0.0304 REMARK 3 L13: 0.0829 L23: 0.0279 REMARK 3 S TENSOR REMARK 3 S11: -0.3023 S12: 0.1714 S13: 0.1991 REMARK 3 S21: -0.0346 S22: 0.0813 S23: 0.2500 REMARK 3 S31: 0.0304 S32: 0.1542 S33: -0.0063 REMARK 3 TLS GROUP : 29 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 12 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A):-106.9293 40.1282 -70.0949 REMARK 3 T TENSOR REMARK 3 T11: 0.0864 T22: 0.4604 REMARK 3 T33: 0.3633 T12: -0.0217 REMARK 3 T13: -0.0730 T23: -0.0600 REMARK 3 L TENSOR REMARK 3 L11: 0.1666 L22: 0.2187 REMARK 3 L33: 0.1051 L12: 0.2481 REMARK 3 L13: 0.1094 L23: 0.1410 REMARK 3 S TENSOR REMARK 3 S11: -0.2535 S12: -0.0037 S13: 0.0147 REMARK 3 S21: -0.3290 S22: -0.0154 S23: 0.1608 REMARK 3 S31: -0.3758 S32: -0.0305 S33: -0.0334 REMARK 3 TLS GROUP : 30 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): -74.8629 41.4401 -60.1896 REMARK 3 T TENSOR REMARK 3 T11: 0.2693 T22: 0.4535 REMARK 3 T33: 0.3620 T12: -0.0128 REMARK 3 T13: -0.0055 T23: 0.0027 REMARK 3 L TENSOR REMARK 3 L11: 0.0620 L22: 0.0946 REMARK 3 L33: 0.0090 L12: -0.0949 REMARK 3 L13: -0.0081 L23: 0.0332 REMARK 3 S TENSOR REMARK 3 S11: 0.1963 S12: 0.1869 S13: -0.0277 REMARK 3 S21: -0.0137 S22: 0.1102 S23: -0.0846 REMARK 3 S31: 0.0217 S32: -0.1582 S33: 0.0166 REMARK 3 TLS GROUP : 31 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 150 THROUGH 236 ) REMARK 3 ORIGIN FOR THE GROUP (A): -88.4430 27.5265 -64.7931 REMARK 3 T TENSOR REMARK 3 T11: 0.3548 T22: 0.3204 REMARK 3 T33: 0.3482 T12: 0.0101 REMARK 3 T13: -0.0051 T23: -0.0705 REMARK 3 L TENSOR REMARK 3 L11: 0.0810 L22: 0.0578 REMARK 3 L33: 0.1189 L12: -0.0627 REMARK 3 L13: 0.1315 L23: -0.0389 REMARK 3 S TENSOR REMARK 3 S11: 0.2225 S12: -0.0284 S13: -0.3555 REMARK 3 S21: -0.2490 S22: 0.1311 S23: 0.2863 REMARK 3 S31: 0.2201 S32: -0.0764 S33: 0.0226 REMARK 3 TLS GROUP : 32 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 237 THROUGH 298 ) REMARK 3 ORIGIN FOR THE GROUP (A): -73.0629 37.9377 -66.9461 REMARK 3 T TENSOR REMARK 3 T11: 0.4156 T22: 0.3447 REMARK 3 T33: 0.3261 T12: -0.0282 REMARK 3 T13: -0.1294 T23: -0.1388 REMARK 3 L TENSOR REMARK 3 L11: 0.2906 L22: 0.3869 REMARK 3 L33: 0.5409 L12: 0.2518 REMARK 3 L13: -0.3967 L23: -0.3874 REMARK 3 S TENSOR REMARK 3 S11: -0.2107 S12: -0.0536 S13: -0.1892 REMARK 3 S21: -0.0810 S22: -0.3264 S23: -0.0849 REMARK 3 S31: 0.3086 S32: 0.1044 S33: -0.4355 REMARK 3 TLS GROUP : 33 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 299 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -99.8439 46.7789 -66.3665 REMARK 3 T TENSOR REMARK 3 T11: 0.4522 T22: 0.3585 REMARK 3 T33: 0.3868 T12: 0.0337 REMARK 3 T13: -0.1300 T23: -0.0855 REMARK 3 L TENSOR REMARK 3 L11: 0.1764 L22: 0.1155 REMARK 3 L33: 0.0878 L12: 0.1133 REMARK 3 L13: -0.1414 L23: -0.1120 REMARK 3 S TENSOR REMARK 3 S11: 0.1113 S12: 0.1036 S13: 0.1015 REMARK 3 S21: -0.0319 S22: 0.1509 S23: 0.0552 REMARK 3 S31: -0.0595 S32: -0.1275 S33: 0.2439 REMARK 3 TLS GROUP : 34 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A):-118.1205 20.7054 -78.2224 REMARK 3 T TENSOR REMARK 3 T11: 0.7319 T22: 1.2392 REMARK 3 T33: 0.8918 T12: -0.1262 REMARK 3 T13: -0.2252 T23: -0.1255 REMARK 3 L TENSOR REMARK 3 L11: 0.0146 L22: 0.0025 REMARK 3 L33: 0.0021 L12: 0.0052 REMARK 3 L13: -0.0005 L23: 0.0014 REMARK 3 S TENSOR REMARK 3 S11: -0.0365 S12: -0.0816 S13: -0.1391 REMARK 3 S21: 0.0661 S22: -0.0567 S23: 0.1436 REMARK 3 S31: -0.0158 S32: 0.0005 S33: -0.0000 REMARK 3 TLS GROUP : 35 REMARK 3 SELECTION: CHAIN 'M' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A):-112.9808 44.5015 -74.5269 REMARK 3 T TENSOR REMARK 3 T11: 0.4130 T22: 0.6471 REMARK 3 T33: 0.6361 T12: 0.0545 REMARK 3 T13: 0.0354 T23: 0.0714 REMARK 3 L TENSOR REMARK 3 L11: 0.0358 L22: 0.0386 REMARK 3 L33: 0.0427 L12: 0.0341 REMARK 3 L13: -0.0085 L23: 0.0044 REMARK 3 S TENSOR REMARK 3 S11: -0.0462 S12: -0.0494 S13: -0.1368 REMARK 3 S21: -0.2139 S22: -0.1264 S23: -0.1533 REMARK 3 S31: -0.2500 S32: -0.2329 S33: 0.0006 REMARK 3 TLS GROUP : 36 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 12 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): 5.1280 -81.2246 -8.4331 REMARK 3 T TENSOR REMARK 3 T11: 0.0945 T22: -0.1534 REMARK 3 T33: 0.2255 T12: 0.8335 REMARK 3 T13: -0.4225 T23: 0.6990 REMARK 3 L TENSOR REMARK 3 L11: 0.0096 L22: 0.0876 REMARK 3 L33: 0.0291 L12: -0.1435 REMARK 3 L13: -0.0464 L23: 0.0612 REMARK 3 S TENSOR REMARK 3 S11: 0.2735 S12: -0.4570 S13: -0.3847 REMARK 3 S21: 0.1839 S22: -0.1835 S23: 0.1202 REMARK 3 S31: 0.0012 S32: 0.1053 S33: 0.0255 REMARK 3 TLS GROUP : 37 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): -11.4616 -61.1681 -29.6914 REMARK 3 T TENSOR REMARK 3 T11: 0.3107 T22: 0.5784 REMARK 3 T33: 0.5333 T12: 0.3045 REMARK 3 T13: -0.0882 T23: -0.0229 REMARK 3 L TENSOR REMARK 3 L11: 0.0625 L22: 0.0691 REMARK 3 L33: 0.0259 L12: 0.0296 REMARK 3 L13: -0.0237 L23: 0.0250 REMARK 3 S TENSOR REMARK 3 S11: 0.0944 S12: 0.0027 S13: -0.0064 REMARK 3 S21: -0.0413 S22: -0.0754 S23: 0.0289 REMARK 3 S31: -0.0414 S32: -0.1689 S33: 0.0310 REMARK 3 TLS GROUP : 38 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 150 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): -23.3521 -76.8690 -14.3748 REMARK 3 T TENSOR REMARK 3 T11: 0.3434 T22: 0.7203 REMARK 3 T33: 0.6401 T12: 0.1392 REMARK 3 T13: 0.0710 T23: 0.1512 REMARK 3 L TENSOR REMARK 3 L11: 0.0049 L22: 0.0446 REMARK 3 L33: 0.0135 L12: -0.0321 REMARK 3 L13: -0.0107 L23: 0.0336 REMARK 3 S TENSOR REMARK 3 S11: -0.1073 S12: 0.0418 S13: 0.0856 REMARK 3 S21: -0.2353 S22: -0.2799 S23: -0.2120 REMARK 3 S31: 0.0218 S32: -0.0466 S33: -0.0105 REMARK 3 TLS GROUP : 39 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 171 THROUGH 295 ) REMARK 3 ORIGIN FOR THE GROUP (A): -14.5992 -65.9428 -19.7943 REMARK 3 T TENSOR REMARK 3 T11: 0.3323 T22: 0.4129 REMARK 3 T33: 0.3668 T12: 0.1042 REMARK 3 T13: -0.0330 T23: 0.1364 REMARK 3 L TENSOR REMARK 3 L11: 0.1657 L22: 0.1036 REMARK 3 L33: 0.0250 L12: 0.1073 REMARK 3 L13: -0.0087 L23: 0.0806 REMARK 3 S TENSOR REMARK 3 S11: -0.0765 S12: -0.2107 S13: 0.0658 REMARK 3 S21: -0.1467 S22: -0.0160 S23: 0.0027 REMARK 3 S31: 0.1231 S32: 0.0559 S33: -0.0001 REMARK 3 TLS GROUP : 40 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 296 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): 6.8806 -74.7569 -16.3174 REMARK 3 T TENSOR REMARK 3 T11: 0.3661 T22: 0.4859 REMARK 3 T33: 0.4652 T12: 0.1656 REMARK 3 T13: -0.0866 T23: 0.2076 REMARK 3 L TENSOR REMARK 3 L11: 0.3899 L22: 0.3851 REMARK 3 L33: 0.0636 L12: 0.1694 REMARK 3 L13: 0.0494 L23: 0.1609 REMARK 3 S TENSOR REMARK 3 S11: 0.1545 S12: -0.0203 S13: 0.1414 REMARK 3 S21: -0.0065 S22: -0.1491 S23: 0.0714 REMARK 3 S31: 0.2110 S32: 0.0407 S33: -0.0079 REMARK 3 TLS GROUP : 41 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -4.6528 -93.0868 9.8271 REMARK 3 T TENSOR REMARK 3 T11: 0.9345 T22: 0.1095 REMARK 3 T33: 1.0562 T12: 0.0470 REMARK 3 T13: -0.2832 T23: 0.1954 REMARK 3 L TENSOR REMARK 3 L11: 0.0310 L22: 0.0187 REMARK 3 L33: 0.0952 L12: -0.0001 REMARK 3 L13: -0.0223 L23: 0.0338 REMARK 3 S TENSOR REMARK 3 S11: 0.0795 S12: -0.0224 S13: 0.0290 REMARK 3 S21: -0.0812 S22: 0.0339 S23: 0.0102 REMARK 3 S31: 0.0028 S32: 0.0368 S33: 0.0885 REMARK 3 TLS GROUP : 42 REMARK 3 SELECTION: CHAIN 'P' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): 12.4754 -81.8557 -3.8494 REMARK 3 T TENSOR REMARK 3 T11: 0.4516 T22: 0.7043 REMARK 3 T33: 0.8151 T12: 0.1629 REMARK 3 T13: 0.0780 T23: 0.2391 REMARK 3 L TENSOR REMARK 3 L11: 0.0311 L22: 0.0531 REMARK 3 L33: 0.0767 L12: -0.0363 REMARK 3 L13: -0.0382 L23: 0.0045 REMARK 3 S TENSOR REMARK 3 S11: 0.0196 S12: 0.1511 S13: 0.0146 REMARK 3 S21: 0.3059 S22: -0.0338 S23: 0.2554 REMARK 3 S31: 0.2208 S32: 0.2710 S33: -0.0000 REMARK 3 TLS GROUP : 43 REMARK 3 SELECTION: CHAIN 'S' AND (RESID 12 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): -24.7661 -57.9814 3.6634 REMARK 3 T TENSOR REMARK 3 T11: 0.3854 T22: 0.5413 REMARK 3 T33: 0.4037 T12: -0.0440 REMARK 3 T13: 0.0750 T23: 0.3836 REMARK 3 L TENSOR REMARK 3 L11: 0.3107 L22: 0.0164 REMARK 3 L33: 0.4870 L12: 0.0883 REMARK 3 L13: -0.2256 L23: -0.0301 REMARK 3 S TENSOR REMARK 3 S11: -0.4767 S12: -0.2484 S13: -0.5194 REMARK 3 S21: 0.0775 S22: 0.1626 S23: 0.1699 REMARK 3 S31: 0.0964 S32: -0.1313 S33: -0.4722 REMARK 3 TLS GROUP : 44 REMARK 3 SELECTION: CHAIN 'S' AND (RESID 116 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): -24.8632 -39.2814 -19.2938 REMARK 3 T TENSOR REMARK 3 T11: 0.4743 T22: 0.3164 REMARK 3 T33: 0.2902 T12: 0.1600 REMARK 3 T13: -0.0224 T23: 0.0742 REMARK 3 L TENSOR REMARK 3 L11: 0.2474 L22: 0.2203 REMARK 3 L33: 0.2308 L12: -0.0606 REMARK 3 L13: 0.1845 L23: -0.1544 REMARK 3 S TENSOR REMARK 3 S11: -0.0752 S12: -0.0736 S13: -0.0054 REMARK 3 S21: -0.1085 S22: -0.0826 S23: 0.3140 REMARK 3 S31: -0.4381 S32: 0.0723 S33: -0.1420 REMARK 3 TLS GROUP : 45 REMARK 3 SELECTION: CHAIN 'S' AND (RESID 171 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.4916 -47.1894 -11.7998 REMARK 3 T TENSOR REMARK 3 T11: 0.2297 T22: 0.4641 REMARK 3 T33: 0.3553 T12: 0.0666 REMARK 3 T13: 0.0216 T23: 0.0779 REMARK 3 L TENSOR REMARK 3 L11: 0.2396 L22: 0.1833 REMARK 3 L33: 0.0950 L12: -0.0635 REMARK 3 L13: 0.1534 L23: -0.1030 REMARK 3 S TENSOR REMARK 3 S11: 0.0304 S12: -0.0471 S13: 0.0048 REMARK 3 S21: -0.0570 S22: -0.0790 S23: 0.1058 REMARK 3 S31: 0.1276 S32: 0.1494 S33: -0.0094 REMARK 3 TLS GROUP : 46 REMARK 3 SELECTION: CHAIN 'S' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -34.0216 -47.2655 22.9963 REMARK 3 T TENSOR REMARK 3 T11: 0.8196 T22: 1.1831 REMARK 3 T33: 0.5811 T12: 0.1187 REMARK 3 T13: -0.0013 T23: 0.4921 REMARK 3 L TENSOR REMARK 3 L11: 0.0251 L22: 0.0383 REMARK 3 L33: 0.0129 L12: 0.0018 REMARK 3 L13: 0.0159 L23: 0.0142 REMARK 3 S TENSOR REMARK 3 S11: 0.0371 S12: 0.0734 S13: 0.0450 REMARK 3 S21: 0.0651 S22: 0.1358 S23: 0.0844 REMARK 3 S31: 0.0230 S32: 0.0493 S33: 0.0603 REMARK 3 TLS GROUP : 47 REMARK 3 SELECTION: CHAIN 'S' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.2696 -63.4765 9.4889 REMARK 3 T TENSOR REMARK 3 T11: 0.6523 T22: 0.7497 REMARK 3 T33: 0.5765 T12: 0.1621 REMARK 3 T13: 0.0705 T23: 0.2332 REMARK 3 L TENSOR REMARK 3 L11: 0.0202 L22: 0.0464 REMARK 3 L33: 0.0278 L12: 0.0004 REMARK 3 L13: -0.0037 L23: 0.0100 REMARK 3 S TENSOR REMARK 3 S11: 0.1314 S12: -0.1280 S13: 0.1120 REMARK 3 S21: -0.1687 S22: -0.1517 S23: -0.1566 REMARK 3 S31: 0.0197 S32: -0.2323 S33: -0.0000 REMARK 3 TLS GROUP : 48 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 12 THROUGH 77 ) REMARK 3 ORIGIN FOR THE GROUP (A): -14.3355 -18.9586 1.0956 REMARK 3 T TENSOR REMARK 3 T11: 0.2778 T22: 0.3225 REMARK 3 T33: 0.3358 T12: 0.0212 REMARK 3 T13: -0.0544 T23: 0.0188 REMARK 3 L TENSOR REMARK 3 L11: 0.1434 L22: 0.0959 REMARK 3 L33: 0.1217 L12: -0.1349 REMARK 3 L13: -0.1021 L23: 0.0866 REMARK 3 S TENSOR REMARK 3 S11: -0.0783 S12: -0.1796 S13: 0.0006 REMARK 3 S21: 0.0754 S22: -0.2303 S23: -0.1025 REMARK 3 S31: -0.0370 S32: -0.1663 S33: -0.0109 REMARK 3 TLS GROUP : 49 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 78 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): -10.6778 -22.0188 0.4868 REMARK 3 T TENSOR REMARK 3 T11: -0.0907 T22: 0.2406 REMARK 3 T33: 0.3862 T12: 0.6123 REMARK 3 T13: 0.0922 T23: -0.1887 REMARK 3 L TENSOR REMARK 3 L11: 0.3863 L22: 0.6495 REMARK 3 L33: 0.8198 L12: -0.0184 REMARK 3 L13: 0.0479 L23: -0.2973 REMARK 3 S TENSOR REMARK 3 S11: 0.2414 S12: -0.1426 S13: 0.1111 REMARK 3 S21: 0.5210 S22: -0.3036 S23: 0.0030 REMARK 3 S31: -0.3927 S32: -0.0103 S33: -0.3531 REMARK 3 TLS GROUP : 50 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 116 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): -2.6398 -21.3154 -26.8917 REMARK 3 T TENSOR REMARK 3 T11: 0.3762 T22: 0.5521 REMARK 3 T33: 0.4254 T12: 0.0094 REMARK 3 T13: -0.1020 T23: 0.0509 REMARK 3 L TENSOR REMARK 3 L11: 0.1113 L22: 0.1276 REMARK 3 L33: 0.0627 L12: -0.0592 REMARK 3 L13: -0.0479 L23: 0.0503 REMARK 3 S TENSOR REMARK 3 S11: -0.3879 S12: -0.0475 S13: -0.0734 REMARK 3 S21: -0.2570 S22: -0.0941 S23: -0.1272 REMARK 3 S31: -0.4829 S32: 0.3805 S33: -0.0577 REMARK 3 TLS GROUP : 51 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 171 THROUGH 217 ) REMARK 3 ORIGIN FOR THE GROUP (A): -5.3014 -16.4452 -23.3642 REMARK 3 T TENSOR REMARK 3 T11: 0.2299 T22: 0.5508 REMARK 3 T33: 0.4125 T12: 0.0113 REMARK 3 T13: -0.0158 T23: 0.0301 REMARK 3 L TENSOR REMARK 3 L11: 0.0085 L22: 0.0671 REMARK 3 L33: 0.0041 L12: -0.0404 REMARK 3 L13: -0.0082 L23: 0.0039 REMARK 3 S TENSOR REMARK 3 S11: -0.1077 S12: -0.3153 S13: 0.1984 REMARK 3 S21: -0.0273 S22: -0.1446 S23: -0.2533 REMARK 3 S31: -0.1668 S32: -0.0580 S33: -0.0000 REMARK 3 TLS GROUP : 52 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 218 THROUGH 279 ) REMARK 3 ORIGIN FOR THE GROUP (A): 3.8844 -23.6666 -24.6027 REMARK 3 T TENSOR REMARK 3 T11: 0.3427 T22: 0.5624 REMARK 3 T33: 0.4034 T12: 0.0136 REMARK 3 T13: 0.0140 T23: 0.0250 REMARK 3 L TENSOR REMARK 3 L11: 0.0481 L22: 0.0854 REMARK 3 L33: 0.0124 L12: 0.0310 REMARK 3 L13: -0.0558 L23: 0.0346 REMARK 3 S TENSOR REMARK 3 S11: 0.0916 S12: -0.3539 S13: 0.0590 REMARK 3 S21: -0.1769 S22: -0.2777 S23: -0.1034 REMARK 3 S31: -0.1695 S32: 0.2395 S33: -0.0100 REMARK 3 TLS GROUP : 53 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 280 THROUGH 324 ) REMARK 3 ORIGIN FOR THE GROUP (A): -3.8325 -26.9638 -2.3988 REMARK 3 T TENSOR REMARK 3 T11: 0.4880 T22: 0.6131 REMARK 3 T33: 0.2938 T12: 0.0135 REMARK 3 T13: -0.1235 T23: 0.0254 REMARK 3 L TENSOR REMARK 3 L11: 0.1771 L22: 0.0089 REMARK 3 L33: 0.0272 L12: 0.0044 REMARK 3 L13: -0.0402 L23: 0.0036 REMARK 3 S TENSOR REMARK 3 S11: -0.2006 S12: -0.2677 S13: 0.0233 REMARK 3 S21: 0.2599 S22: -0.2205 S23: -0.0069 REMARK 3 S31: -0.1350 S32: 0.1621 S33: -0.0615 REMARK 3 TLS GROUP : 54 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 325 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): -22.8465 -30.3015 -12.9869 REMARK 3 T TENSOR REMARK 3 T11: 0.0767 T22: 0.4444 REMARK 3 T33: 0.3064 T12: 0.0046 REMARK 3 T13: -0.1198 T23: -0.0031 REMARK 3 L TENSOR REMARK 3 L11: 0.1360 L22: 0.0249 REMARK 3 L33: 0.0788 L12: -0.0556 REMARK 3 L13: 0.0552 L23: -0.0458 REMARK 3 S TENSOR REMARK 3 S11: -0.0215 S12: -0.0936 S13: -0.0190 REMARK 3 S21: 0.1029 S22: 0.2444 S23: 0.1299 REMARK 3 S31: -0.1276 S32: -0.1191 S33: 0.1803 REMARK 3 TLS GROUP : 55 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): -2.4068 -2.3475 12.8591 REMARK 3 T TENSOR REMARK 3 T11: 0.9616 T22: 1.3759 REMARK 3 T33: 0.6112 T12: 0.1607 REMARK 3 T13: -0.1827 T23: -0.1803 REMARK 3 L TENSOR REMARK 3 L11: 0.0127 L22: 0.0136 REMARK 3 L33: 0.0135 L12: 0.0149 REMARK 3 L13: -0.0160 L23: -0.0184 REMARK 3 S TENSOR REMARK 3 S11: 0.0197 S12: 0.0293 S13: 0.1072 REMARK 3 S21: -0.0264 S22: 0.1589 S23: 0.1535 REMARK 3 S31: -0.0598 S32: -0.0030 S33: 0.0000 REMARK 3 TLS GROUP : 56 REMARK 3 SELECTION: CHAIN 'V' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): -15.0026 -23.1673 8.7447 REMARK 3 T TENSOR REMARK 3 T11: 0.5177 T22: 0.7927 REMARK 3 T33: 0.5228 T12: 0.1177 REMARK 3 T13: 0.0325 T23: 0.0220 REMARK 3 L TENSOR REMARK 3 L11: 0.0493 L22: 0.0359 REMARK 3 L33: 0.0180 L12: 0.0322 REMARK 3 L13: -0.0231 L23: 0.0159 REMARK 3 S TENSOR REMARK 3 S11: -0.0827 S12: -0.1291 S13: 0.2015 REMARK 3 S21: 0.0716 S22: 0.0857 S23: -0.1109 REMARK 3 S31: 0.1918 S32: -0.1160 S33: -0.0000 REMARK 3 TLS GROUP : 57 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 12 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): 24.2908 -19.8275 -12.8449 REMARK 3 T TENSOR REMARK 3 T11: 0.1732 T22: 0.4634 REMARK 3 T33: 1.0152 T12: -0.2128 REMARK 3 T13: -0.2644 T23: 0.1784 REMARK 3 L TENSOR REMARK 3 L11: 0.3553 L22: 0.5375 REMARK 3 L33: 0.2266 L12: 0.0803 REMARK 3 L13: 0.2449 L23: -0.0715 REMARK 3 S TENSOR REMARK 3 S11: 0.0250 S12: -0.1215 S13: 0.4611 REMARK 3 S21: -0.1698 S22: -0.2276 S23: -0.6915 REMARK 3 S31: 0.0150 S32: 0.0165 S33: -0.0264 REMARK 3 TLS GROUP : 58 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): 10.6999 -38.8892 -36.8891 REMARK 3 T TENSOR REMARK 3 T11: 0.2191 T22: 0.7250 REMARK 3 T33: 0.3654 T12: 0.2030 REMARK 3 T13: -0.0370 T23: 0.0169 REMARK 3 L TENSOR REMARK 3 L11: 0.2013 L22: 1.1953 REMARK 3 L33: 0.0127 L12: 0.4743 REMARK 3 L13: -0.0171 L23: -0.0570 REMARK 3 S TENSOR REMARK 3 S11: 0.3011 S12: 0.2456 S13: -0.0838 REMARK 3 S21: 0.3178 S22: -0.1962 S23: 0.0153 REMARK 3 S31: -0.0544 S32: -0.0794 S33: 0.0212 REMARK 3 TLS GROUP : 59 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 150 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): 35.4729 -36.7136 -34.1722 REMARK 3 T TENSOR REMARK 3 T11: 0.4365 T22: 0.9181 REMARK 3 T33: 0.8802 T12: 0.1410 REMARK 3 T13: 0.1683 T23: 0.3338 REMARK 3 L TENSOR REMARK 3 L11: 0.0012 L22: 0.1760 REMARK 3 L33: 0.2870 L12: 0.0066 REMARK 3 L13: -0.0011 L23: -0.1428 REMARK 3 S TENSOR REMARK 3 S11: 0.0086 S12: -0.1376 S13: -0.0851 REMARK 3 S21: -0.2080 S22: 0.1167 S23: 0.0725 REMARK 3 S31: 0.0969 S32: -0.0437 S33: 0.0458 REMARK 3 TLS GROUP : 60 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 171 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): 18.5876 -32.5695 -25.9830 REMARK 3 T TENSOR REMARK 3 T11: -0.4081 T22: 0.6648 REMARK 3 T33: 0.5257 T12: 0.0119 REMARK 3 T13: -0.0989 T23: 0.1591 REMARK 3 L TENSOR REMARK 3 L11: 0.2743 L22: 0.3669 REMARK 3 L33: 0.1839 L12: -0.0603 REMARK 3 L13: 0.1090 L23: 0.1133 REMARK 3 S TENSOR REMARK 3 S11: 0.0835 S12: 0.2304 S13: 0.2664 REMARK 3 S21: -0.4334 S22: -0.2307 S23: -0.4468 REMARK 3 S31: 0.0303 S32: 0.0743 S33: -0.1251 REMARK 3 TLS GROUP : 61 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): 47.1737 -20.3241 -5.9926 REMARK 3 T TENSOR REMARK 3 T11: 0.7845 T22: 1.3092 REMARK 3 T33: 1.0517 T12: -0.4252 REMARK 3 T13: -0.2234 T23: 0.0593 REMARK 3 L TENSOR REMARK 3 L11: 0.0119 L22: 0.0076 REMARK 3 L33: 0.0135 L12: -0.0145 REMARK 3 L13: -0.0121 L23: 0.0116 REMARK 3 S TENSOR REMARK 3 S11: 0.0457 S12: -0.0047 S13: -0.0493 REMARK 3 S21: -0.1502 S22: -0.1218 S23: -0.1559 REMARK 3 S31: -0.1179 S32: -0.1186 S33: -0.0000 REMARK 3 TLS GROUP : 62 REMARK 3 SELECTION: CHAIN 'Y' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): 22.8397 -16.6025 -4.8900 REMARK 3 T TENSOR REMARK 3 T11: 0.5669 T22: 0.5423 REMARK 3 T33: 0.9905 T12: -0.1433 REMARK 3 T13: -0.2274 T23: -0.1144 REMARK 3 L TENSOR REMARK 3 L11: 0.1652 L22: 0.0572 REMARK 3 L33: 0.0526 L12: -0.0347 REMARK 3 L13: 0.0624 L23: -0.0041 REMARK 3 S TENSOR REMARK 3 S11: -0.2946 S12: -0.1346 S13: 0.2144 REMARK 3 S21: 0.1068 S22: -0.0105 S23: -0.0705 REMARK 3 S31: -0.1649 S32: -0.0574 S33: -0.0190 REMARK 3 TLS GROUP : 63 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 12 THROUGH 77 ) REMARK 3 ORIGIN FOR THE GROUP (A): 37.0541 -57.7350 -19.3503 REMARK 3 T TENSOR REMARK 3 T11: 0.2659 T22: 0.7640 REMARK 3 T33: 0.6756 T12: -0.0392 REMARK 3 T13: -0.0546 T23: 0.1364 REMARK 3 L TENSOR REMARK 3 L11: 0.0964 L22: 0.2268 REMARK 3 L33: 0.1646 L12: -0.1775 REMARK 3 L13: -0.1423 L23: 0.2166 REMARK 3 S TENSOR REMARK 3 S11: 0.0757 S12: -0.1725 S13: 0.2617 REMARK 3 S21: -0.0111 S22: -0.1253 S23: -0.3561 REMARK 3 S31: -0.1576 S32: 0.1071 S33: 0.0138 REMARK 3 TLS GROUP : 64 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 78 THROUGH 115 ) REMARK 3 ORIGIN FOR THE GROUP (A): 32.8896 -57.4260 -16.9517 REMARK 3 T TENSOR REMARK 3 T11: -0.0592 T22: 0.9022 REMARK 3 T33: 0.8592 T12: 0.3055 REMARK 3 T13: -0.0877 T23: 0.3273 REMARK 3 L TENSOR REMARK 3 L11: 0.2186 L22: 0.1131 REMARK 3 L33: 0.1707 L12: 0.0266 REMARK 3 L13: -0.2399 L23: -0.0429 REMARK 3 S TENSOR REMARK 3 S11: 0.1141 S12: 0.1542 S13: -0.2793 REMARK 3 S21: 0.0897 S22: -0.0325 S23: -0.4398 REMARK 3 S31: 0.1378 S32: 0.0901 S33: -0.1225 REMARK 3 TLS GROUP : 65 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 116 THROUGH 149 ) REMARK 3 ORIGIN FOR THE GROUP (A): 7.1588 -58.4467 -36.3284 REMARK 3 T TENSOR REMARK 3 T11: 0.4758 T22: 0.5742 REMARK 3 T33: 0.7034 T12: 0.2425 REMARK 3 T13: 0.2316 T23: 0.0843 REMARK 3 L TENSOR REMARK 3 L11: 0.1673 L22: 0.1374 REMARK 3 L33: 0.0109 L12: 0.1014 REMARK 3 L13: -0.0517 L23: -0.0592 REMARK 3 S TENSOR REMARK 3 S11: 0.0701 S12: -0.0275 S13: 0.0612 REMARK 3 S21: -0.2903 S22: -0.0393 S23: 0.0083 REMARK 3 S31: 0.0948 S32: 0.2012 S33: 0.0257 REMARK 3 TLS GROUP : 66 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 150 THROUGH 170 ) REMARK 3 ORIGIN FOR THE GROUP (A): 19.4910 -79.2961 -30.1039 REMARK 3 T TENSOR REMARK 3 T11: 0.6224 T22: 0.3039 REMARK 3 T33: 0.5863 T12: 0.2425 REMARK 3 T13: -0.0692 T23: 0.2492 REMARK 3 L TENSOR REMARK 3 L11: 0.2677 L22: 0.5673 REMARK 3 L33: 0.2824 L12: 0.2017 REMARK 3 L13: -0.0862 L23: 0.2837 REMARK 3 S TENSOR REMARK 3 S11: 0.2662 S12: 0.0711 S13: -0.1073 REMARK 3 S21: -0.1965 S22: 0.1200 S23: 0.1464 REMARK 3 S31: 0.3638 S32: -0.1043 S33: 0.2476 REMARK 3 TLS GROUP : 67 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 171 THROUGH 251 ) REMARK 3 ORIGIN FOR THE GROUP (A): 18.1074 -66.4870 -26.8907 REMARK 3 T TENSOR REMARK 3 T11: 0.4877 T22: 0.6996 REMARK 3 T33: 0.4890 T12: 0.3350 REMARK 3 T13: -0.0470 T23: 0.3559 REMARK 3 L TENSOR REMARK 3 L11: 0.0173 L22: 0.2311 REMARK 3 L33: 0.1792 L12: 0.0549 REMARK 3 L13: 0.0716 L23: 0.1681 REMARK 3 S TENSOR REMARK 3 S11: 0.0287 S12: -0.0122 S13: -0.1186 REMARK 3 S21: 0.2107 S22: -0.1958 S23: -0.1945 REMARK 3 S31: 0.1008 S32: -0.1196 S33: -0.4106 REMARK 3 TLS GROUP : 68 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 252 THROUGH 279 ) REMARK 3 ORIGIN FOR THE GROUP (A): -7.2195 -73.1802 -41.9682 REMARK 3 T TENSOR REMARK 3 T11: 0.4864 T22: 0.5777 REMARK 3 T33: 0.6412 T12: 0.1980 REMARK 3 T13: -0.0258 T23: 0.0074 REMARK 3 L TENSOR REMARK 3 L11: 0.0053 L22: 0.0233 REMARK 3 L33: 0.0154 L12: -0.0001 REMARK 3 L13: -0.0152 L23: 0.0231 REMARK 3 S TENSOR REMARK 3 S11: -0.0664 S12: -0.0430 S13: 0.0728 REMARK 3 S21: -0.2157 S22: -0.1493 S23: 0.4060 REMARK 3 S31: -0.1809 S32: 0.3950 S33: -0.0001 REMARK 3 TLS GROUP : 69 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 280 THROUGH 324 ) REMARK 3 ORIGIN FOR THE GROUP (A): 24.4371 -57.7816 -13.9773 REMARK 3 T TENSOR REMARK 3 T11: 0.2357 T22: 0.6927 REMARK 3 T33: 0.6228 T12: 0.2280 REMARK 3 T13: -0.1896 T23: 0.3811 REMARK 3 L TENSOR REMARK 3 L11: 0.0834 L22: 0.0476 REMARK 3 L33: 0.0338 L12: -0.0339 REMARK 3 L13: -0.0407 L23: 0.0078 REMARK 3 S TENSOR REMARK 3 S11: 0.4124 S12: -0.1581 S13: -0.0875 REMARK 3 S21: 0.0362 S22: -0.0829 S23: -0.2402 REMARK 3 S31: 0.1450 S32: 0.1935 S33: 0.2261 REMARK 3 TLS GROUP : 70 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 325 THROUGH 370 ) REMARK 3 ORIGIN FOR THE GROUP (A): 27.5446 -45.5923 -32.1026 REMARK 3 T TENSOR REMARK 3 T11: 0.2299 T22: 0.7884 REMARK 3 T33: 0.8708 T12: 0.3889 REMARK 3 T13: 0.0525 T23: 0.4733 REMARK 3 L TENSOR REMARK 3 L11: 0.0663 L22: 0.0612 REMARK 3 L33: 0.0328 L12: 0.0772 REMARK 3 L13: 0.0743 L23: 0.0611 REMARK 3 S TENSOR REMARK 3 S11: 0.0625 S12: -0.1129 S13: -0.2154 REMARK 3 S21: 0.0054 S22: -0.0971 S23: -0.1337 REMARK 3 S31: -0.0145 S32: -0.0674 S33: 0.0469 REMARK 3 TLS GROUP : 71 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 371 THROUGH 427 ) REMARK 3 ORIGIN FOR THE GROUP (A): 45.7537 -76.3155 -7.9532 REMARK 3 T TENSOR REMARK 3 T11: 0.2661 T22: 0.8609 REMARK 3 T33: 0.7666 T12: -0.0097 REMARK 3 T13: -0.1430 T23: 0.1665 REMARK 3 L TENSOR REMARK 3 L11: 0.0102 L22: 0.0056 REMARK 3 L33: 0.0052 L12: -0.0032 REMARK 3 L13: 0.0097 L23: 0.0043 REMARK 3 S TENSOR REMARK 3 S11: 0.0782 S12: 0.1599 S13: 0.0749 REMARK 3 S21: -0.0038 S22: -0.1801 S23: -0.2032 REMARK 3 S31: 0.0944 S32: -0.1427 S33: -0.0000 REMARK 3 TLS GROUP : 72 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 428 THROUGH 460 ) REMARK 3 ORIGIN FOR THE GROUP (A): 39.8934 -52.9010 -12.5661 REMARK 3 T TENSOR REMARK 3 T11: 0.4085 T22: 0.8035 REMARK 3 T33: 0.9631 T12: 0.1456 REMARK 3 T13: -0.3603 T23: 0.4409 REMARK 3 L TENSOR REMARK 3 L11: 0.4084 L22: 0.4006 REMARK 3 L33: 0.2789 L12: -0.0973 REMARK 3 L13: -0.3085 L23: 0.1287 REMARK 3 S TENSOR REMARK 3 S11: 0.4174 S12: 0.1432 S13: -0.0231 REMARK 3 S21: -0.1183 S22: 0.0469 S23: 0.0601 REMARK 3 S31: 0.1782 S32: 0.3602 S33: 0.3672 REMARK 3 TLS GROUP : 73 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -47.9429 6.0916 -40.6572 REMARK 3 T TENSOR REMARK 3 T11: 0.2113 T22: 0.2265 REMARK 3 T33: 0.7940 T12: -0.1780 REMARK 3 T13: 0.0033 T23: -0.0463 REMARK 3 L TENSOR REMARK 3 L11: 0.0715 L22: 0.1825 REMARK 3 L33: 0.1560 L12: 0.0474 REMARK 3 L13: 0.1157 L23: 0.1366 REMARK 3 S TENSOR REMARK 3 S11: 0.0082 S12: 0.1634 S13: 0.0118 REMARK 3 S21: 0.0481 S22: 0.1330 S23: -0.1034 REMARK 3 S31: 0.2331 S32: 0.0428 S33: 0.0280 REMARK 3 TLS GROUP : 74 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): -53.9172 15.8641 -43.2581 REMARK 3 T TENSOR REMARK 3 T11: 0.1816 T22: 0.1921 REMARK 3 T33: 0.9830 T12: 0.0621 REMARK 3 T13: 0.0276 T23: -0.2180 REMARK 3 L TENSOR REMARK 3 L11: 0.0188 L22: 0.2188 REMARK 3 L33: 0.3045 L12: 0.0008 REMARK 3 L13: -0.0464 L23: -0.1512 REMARK 3 S TENSOR REMARK 3 S11: -0.2003 S12: -0.0754 S13: -0.0961 REMARK 3 S21: 0.0071 S22: -0.2323 S23: 0.0215 REMARK 3 S31: -0.0523 S32: -0.1057 S33: -0.3844 REMARK 3 TLS GROUP : 75 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 44 THROUGH 87 ) REMARK 3 ORIGIN FOR THE GROUP (A): -46.7819 17.5788 -46.9139 REMARK 3 T TENSOR REMARK 3 T11: 0.3560 T22: 0.0765 REMARK 3 T33: 0.3326 T12: -0.2830 REMARK 3 T13: -0.0314 T23: 0.1280 REMARK 3 L TENSOR REMARK 3 L11: 0.1224 L22: 0.0425 REMARK 3 L33: 0.0938 L12: 0.0151 REMARK 3 L13: -0.0540 L23: 0.0237 REMARK 3 S TENSOR REMARK 3 S11: -0.0802 S12: 0.1250 S13: -0.0039 REMARK 3 S21: 0.0416 S22: 0.0660 S23: -0.2732 REMARK 3 S31: 0.1781 S32: -0.0511 S33: 0.0349 REMARK 3 TLS GROUP : 76 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 88 THROUGH 99 ) REMARK 3 ORIGIN FOR THE GROUP (A): -47.5459 14.3299 -36.1640 REMARK 3 T TENSOR REMARK 3 T11: 0.1951 T22: 0.2181 REMARK 3 T33: 0.6453 T12: 0.3447 REMARK 3 T13: -0.1425 T23: -0.1782 REMARK 3 L TENSOR REMARK 3 L11: 0.2400 L22: 0.0283 REMARK 3 L33: 0.0154 L12: -0.0190 REMARK 3 L13: 0.0558 L23: 0.0019 REMARK 3 S TENSOR REMARK 3 S11: -0.0736 S12: -0.0648 S13: 0.0119 REMARK 3 S21: 0.0408 S22: 0.0753 S23: 0.0775 REMARK 3 S31: 0.0302 S32: 0.0547 S33: -0.0334 REMARK 3 TLS GROUP : 77 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 100 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): -48.3440 5.1393 -21.1556 REMARK 3 T TENSOR REMARK 3 T11: 0.3457 T22: 0.3350 REMARK 3 T33: 0.4696 T12: -0.0689 REMARK 3 T13: 0.0587 T23: -0.0424 REMARK 3 L TENSOR REMARK 3 L11: 0.0973 L22: 0.0076 REMARK 3 L33: 0.0892 L12: 0.0072 REMARK 3 L13: -0.0067 L23: -0.0661 REMARK 3 S TENSOR REMARK 3 S11: 0.0528 S12: -0.0893 S13: 0.1426 REMARK 3 S21: 0.0660 S22: 0.0571 S23: -0.0249 REMARK 3 S31: 0.2119 S32: -0.3240 S33: -0.0014 REMARK 3 TLS GROUP : 78 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 153 THROUGH 169 ) REMARK 3 ORIGIN FOR THE GROUP (A): -51.2632 -4.5900 -16.0917 REMARK 3 T TENSOR REMARK 3 T11: 0.2639 T22: 0.8344 REMARK 3 T33: 0.4794 T12: -0.0159 REMARK 3 T13: -0.1132 T23: 0.0121 REMARK 3 L TENSOR REMARK 3 L11: 0.1563 L22: 0.0468 REMARK 3 L33: 0.2556 L12: 0.0623 REMARK 3 L13: -0.1969 L23: -0.0765 REMARK 3 S TENSOR REMARK 3 S11: -0.1166 S12: -0.0354 S13: -0.0056 REMARK 3 S21: -0.0797 S22: -0.2079 S23: 0.0709 REMARK 3 S31: 0.0380 S32: -0.0941 S33: -0.0098 REMARK 3 TLS GROUP : 79 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 170 THROUGH 180 ) REMARK 3 ORIGIN FOR THE GROUP (A): -43.4874 5.5200 -15.5654 REMARK 3 T TENSOR REMARK 3 T11: 0.6066 T22: 0.3194 REMARK 3 T33: 0.3877 T12: -0.2165 REMARK 3 T13: -0.0217 T23: -0.4017 REMARK 3 L TENSOR REMARK 3 L11: 0.1393 L22: 0.3726 REMARK 3 L33: 0.3038 L12: 0.1050 REMARK 3 L13: 0.0298 L23: 0.1505 REMARK 3 S TENSOR REMARK 3 S11: -0.0603 S12: 0.0245 S13: 0.0185 REMARK 3 S21: -0.1238 S22: -0.0283 S23: -0.1165 REMARK 3 S31: -0.0656 S32: -0.0086 S33: -0.2497 REMARK 3 TLS GROUP : 80 REMARK 3 SELECTION: CHAIN 'B' AND (RESID 181 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -47.7307 -7.7559 -9.6765 REMARK 3 T TENSOR REMARK 3 T11: 0.3521 T22: 0.5090 REMARK 3 T33: 0.4334 T12: -0.0292 REMARK 3 T13: 0.0333 T23: 0.0345 REMARK 3 L TENSOR REMARK 3 L11: 0.0177 L22: 0.0025 REMARK 3 L33: 0.0120 L12: -0.0132 REMARK 3 L13: -0.0067 L23: 0.0048 REMARK 3 S TENSOR REMARK 3 S11: 0.2791 S12: 0.1413 S13: -0.1793 REMARK 3 S21: 0.1297 S22: -0.3095 S23: 0.4079 REMARK 3 S31: -0.1465 S32: -0.1084 S33: 0.0000 REMARK 3 TLS GROUP : 81 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 1 THROUGH 17 ) REMARK 3 ORIGIN FOR THE GROUP (A): -56.7261 27.8037 -20.7421 REMARK 3 T TENSOR REMARK 3 T11: -0.2216 T22: 0.5848 REMARK 3 T33: 0.6708 T12: -0.1260 REMARK 3 T13: 0.3143 T23: 0.0552 REMARK 3 L TENSOR REMARK 3 L11: 0.0661 L22: 0.1994 REMARK 3 L33: 0.0445 L12: -0.1212 REMARK 3 L13: -0.0478 L23: 0.0828 REMARK 3 S TENSOR REMARK 3 S11: -0.1188 S12: -0.0658 S13: 0.1731 REMARK 3 S21: 0.1265 S22: -0.0519 S23: -0.0542 REMARK 3 S31: 0.0142 S32: -0.1135 S33: -0.1738 REMARK 3 TLS GROUP : 82 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 18 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): -58.9445 31.2865 -29.0317 REMARK 3 T TENSOR REMARK 3 T11: 0.2999 T22: 0.0677 REMARK 3 T33: 0.4883 T12: -0.0352 REMARK 3 T13: 0.0651 T23: 0.0933 REMARK 3 L TENSOR REMARK 3 L11: 0.0026 L22: 0.3227 REMARK 3 L33: 0.0909 L12: -0.0010 REMARK 3 L13: 0.0201 L23: -0.0478 REMARK 3 S TENSOR REMARK 3 S11: 0.0234 S12: -0.1249 S13: -0.0520 REMARK 3 S21: 0.0584 S22: 0.0875 S23: -0.1213 REMARK 3 S31: -0.1410 S32: 0.0867 S33: 0.0509 REMARK 3 TLS GROUP : 83 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 39 THROUGH 61 ) REMARK 3 ORIGIN FOR THE GROUP (A): -66.5682 22.2011 -32.2138 REMARK 3 T TENSOR REMARK 3 T11: -0.0050 T22: 0.2175 REMARK 3 T33: 0.5481 T12: -0.0960 REMARK 3 T13: 0.2290 T23: 0.0569 REMARK 3 L TENSOR REMARK 3 L11: 0.0727 L22: 0.0118 REMARK 3 L33: 0.0268 L12: -0.0235 REMARK 3 L13: 0.0150 L23: 0.0081 REMARK 3 S TENSOR REMARK 3 S11: -0.0221 S12: 0.0203 S13: 0.1412 REMARK 3 S21: -0.0249 S22: -0.0259 S23: 0.0858 REMARK 3 S31: -0.0053 S32: -0.0364 S33: -0.0720 REMARK 3 TLS GROUP : 84 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 62 THROUGH 90 ) REMARK 3 ORIGIN FOR THE GROUP (A): -63.7454 27.1868 -25.5350 REMARK 3 T TENSOR REMARK 3 T11: 0.1305 T22: 0.5926 REMARK 3 T33: 0.4835 T12: -0.2291 REMARK 3 T13: 0.2452 T23: -0.0813 REMARK 3 L TENSOR REMARK 3 L11: 0.0956 L22: -0.0002 REMARK 3 L33: 0.0227 L12: -0.0071 REMARK 3 L13: -0.0120 L23: 0.0117 REMARK 3 S TENSOR REMARK 3 S11: -0.1349 S12: -0.0487 S13: 0.0942 REMARK 3 S21: 0.0404 S22: -0.0219 S23: -0.0937 REMARK 3 S31: 0.1954 S32: -0.0149 S33: -0.0445 REMARK 3 TLS GROUP : 85 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 91 THROUGH 139 ) REMARK 3 ORIGIN FOR THE GROUP (A): -48.4658 11.5860 -12.2272 REMARK 3 T TENSOR REMARK 3 T11: 0.1563 T22: 0.2364 REMARK 3 T33: 0.3758 T12: -0.0725 REMARK 3 T13: -0.0742 T23: -0.0920 REMARK 3 L TENSOR REMARK 3 L11: 0.3141 L22: 0.2939 REMARK 3 L33: 0.3828 L12: 0.0773 REMARK 3 L13: -0.1669 L23: 0.2047 REMARK 3 S TENSOR REMARK 3 S11: 0.0503 S12: -0.0850 S13: 0.1178 REMARK 3 S21: 0.0591 S22: 0.1301 S23: -0.3953 REMARK 3 S31: 0.1813 S32: 0.2397 S33: 0.4035 REMARK 3 TLS GROUP : 86 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 140 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): -45.4167 12.9845 -5.1665 REMARK 3 T TENSOR REMARK 3 T11: 0.2914 T22: 0.5390 REMARK 3 T33: 0.5501 T12: 0.0442 REMARK 3 T13: -0.2196 T23: 0.0078 REMARK 3 L TENSOR REMARK 3 L11: 0.0055 L22: 0.0050 REMARK 3 L33: 0.0729 L12: -0.0048 REMARK 3 L13: -0.0230 L23: 0.0278 REMARK 3 S TENSOR REMARK 3 S11: -0.0795 S12: 0.0517 S13: 0.1166 REMARK 3 S21: 0.0828 S22: -0.1322 S23: -0.2049 REMARK 3 S31: 0.2021 S32: 0.0072 S33: -0.0139 REMARK 3 TLS GROUP : 87 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 173 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): -34.6912 4.7603 -3.7929 REMARK 3 T TENSOR REMARK 3 T11: 0.2812 T22: 0.9354 REMARK 3 T33: 0.5594 T12: -0.1568 REMARK 3 T13: -0.1021 T23: -0.1535 REMARK 3 L TENSOR REMARK 3 L11: 0.0345 L22: 0.0034 REMARK 3 L33: 0.0524 L12: -0.0057 REMARK 3 L13: -0.0448 L23: 0.0051 REMARK 3 S TENSOR REMARK 3 S11: 0.0644 S12: 0.0179 S13: 0.0182 REMARK 3 S21: -0.0006 S22: 0.0720 S23: -0.0942 REMARK 3 S31: -0.0757 S32: 0.0029 S33: 0.0340 REMARK 3 TLS GROUP : 88 REMARK 3 SELECTION: CHAIN 'C' AND (RESID 189 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -41.3106 8.6059 6.0088 REMARK 3 T TENSOR REMARK 3 T11: 0.4429 T22: 0.7245 REMARK 3 T33: 0.7021 T12: 0.1980 REMARK 3 T13: -0.1100 T23: -0.0642 REMARK 3 L TENSOR REMARK 3 L11: 0.0244 L22: 0.0003 REMARK 3 L33: 0.0094 L12: 0.0102 REMARK 3 L13: 0.0288 L23: 0.0011 REMARK 3 S TENSOR REMARK 3 S11: 0.0504 S12: -0.1973 S13: 0.0711 REMARK 3 S21: 0.0601 S22: -0.0097 S23: -0.0115 REMARK 3 S31: -0.0406 S32: 0.1963 S33: -0.0000 REMARK 3 TLS GROUP : 89 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -10.0165 40.7947 -70.2953 REMARK 3 T TENSOR REMARK 3 T11: 0.4485 T22: 0.6858 REMARK 3 T33: 1.0021 T12: -0.3892 REMARK 3 T13: 0.4774 T23: -0.1871 REMARK 3 L TENSOR REMARK 3 L11: 0.1047 L22: 0.0275 REMARK 3 L33: 0.0857 L12: 0.0329 REMARK 3 L13: 0.0082 L23: -0.0305 REMARK 3 S TENSOR REMARK 3 S11: 0.0092 S12: 0.1893 S13: -0.0523 REMARK 3 S21: 0.0125 S22: -0.2090 S23: -0.0426 REMARK 3 S31: 0.0270 S32: 0.1064 S33: -0.0334 REMARK 3 TLS GROUP : 90 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.6004 40.5600 -68.0827 REMARK 3 T TENSOR REMARK 3 T11: 0.5456 T22: 0.6224 REMARK 3 T33: 0.8176 T12: -0.0627 REMARK 3 T13: 0.2293 T23: -0.1544 REMARK 3 L TENSOR REMARK 3 L11: 0.0419 L22: 0.0482 REMARK 3 L33: 0.0083 L12: 0.0305 REMARK 3 L13: -0.0223 L23: -0.0081 REMARK 3 S TENSOR REMARK 3 S11: -0.1216 S12: 0.0610 S13: 0.0178 REMARK 3 S21: -0.0773 S22: 0.0291 S23: -0.5530 REMARK 3 S31: 0.0019 S32: 0.1267 S33: -0.0031 REMARK 3 TLS GROUP : 91 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 44 THROUGH 71 ) REMARK 3 ORIGIN FOR THE GROUP (A): -22.8102 49.4562 -65.5828 REMARK 3 T TENSOR REMARK 3 T11: 0.3546 T22: 0.6069 REMARK 3 T33: 0.3962 T12: -0.0138 REMARK 3 T13: 0.1599 T23: 0.0215 REMARK 3 L TENSOR REMARK 3 L11: 0.1158 L22: 0.1348 REMARK 3 L33: 0.3271 L12: 0.0401 REMARK 3 L13: -0.0184 L23: 0.1804 REMARK 3 S TENSOR REMARK 3 S11: -0.0665 S12: -0.0935 S13: -0.0909 REMARK 3 S21: -0.0212 S22: -0.1917 S23: 0.0783 REMARK 3 S31: -0.1166 S32: 0.0225 S33: -0.2880 REMARK 3 TLS GROUP : 92 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 72 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): -6.7893 34.5902 -60.9027 REMARK 3 T TENSOR REMARK 3 T11: 0.1565 T22: 0.9843 REMARK 3 T33: 1.2397 T12: 0.1092 REMARK 3 T13: 0.3053 T23: 0.2679 REMARK 3 L TENSOR REMARK 3 L11: 0.3013 L22: 0.1012 REMARK 3 L33: 0.1911 L12: 0.0775 REMARK 3 L13: 0.0115 L23: -0.0390 REMARK 3 S TENSOR REMARK 3 S11: 0.0793 S12: -0.0879 S13: -0.1787 REMARK 3 S21: 0.0745 S22: 0.1516 S23: -0.1666 REMARK 3 S31: 0.1584 S32: 0.2942 S33: 0.2028 REMARK 3 TLS GROUP : 93 REMARK 3 SELECTION: CHAIN 'E' AND (RESID 153 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): 7.3022 21.5327 -55.9359 REMARK 3 T TENSOR REMARK 3 T11: 0.5634 T22: 1.5213 REMARK 3 T33: 1.4561 T12: 0.4416 REMARK 3 T13: -0.1783 T23: -0.0635 REMARK 3 L TENSOR REMARK 3 L11: 0.0269 L22: 0.0217 REMARK 3 L33: 0.5214 L12: 0.0224 REMARK 3 L13: -0.0864 L23: -0.1032 REMARK 3 S TENSOR REMARK 3 S11: -0.0972 S12: 0.0620 S13: -0.0193 REMARK 3 S21: -0.0850 S22: 0.0545 S23: 0.1415 REMARK 3 S31: 0.4376 S32: 0.1685 S33: -0.0194 REMARK 3 TLS GROUP : 94 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 1 THROUGH 76 ) REMARK 3 ORIGIN FOR THE GROUP (A): -28.9552 30.4863 -50.9000 REMARK 3 T TENSOR REMARK 3 T11: -0.3555 T22: 0.2143 REMARK 3 T33: 0.5441 T12: -0.0317 REMARK 3 T13: 0.3155 T23: 0.0764 REMARK 3 L TENSOR REMARK 3 L11: 0.0188 L22: 0.1899 REMARK 3 L33: 0.1072 L12: 0.0086 REMARK 3 L13: 0.0335 L23: 0.0054 REMARK 3 S TENSOR REMARK 3 S11: -0.1205 S12: -0.1854 S13: -0.2175 REMARK 3 S21: 0.0799 S22: -0.0443 S23: -0.2966 REMARK 3 S31: 0.0441 S32: 0.3258 S33: -0.1803 REMARK 3 TLS GROUP : 95 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 77 THROUGH 102 ) REMARK 3 ORIGIN FOR THE GROUP (A): -25.3050 32.8037 -52.9520 REMARK 3 T TENSOR REMARK 3 T11: 0.5140 T22: 0.2186 REMARK 3 T33: 0.5792 T12: -0.0867 REMARK 3 T13: 0.0520 T23: -0.0109 REMARK 3 L TENSOR REMARK 3 L11: 0.0539 L22: -0.0017 REMARK 3 L33: 0.0749 L12: 0.0055 REMARK 3 L13: 0.0708 L23: 0.0003 REMARK 3 S TENSOR REMARK 3 S11: 0.1322 S12: 0.0183 S13: 0.1676 REMARK 3 S21: -0.1228 S22: 0.0364 S23: 0.0726 REMARK 3 S31: -0.1643 S32: 0.1871 S33: 0.0491 REMARK 3 TLS GROUP : 96 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 103 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -13.2277 18.2578 -40.7912 REMARK 3 T TENSOR REMARK 3 T11: 1.0111 T22: 0.8668 REMARK 3 T33: 1.0996 T12: 0.1914 REMARK 3 T13: -0.0800 T23: 0.1761 REMARK 3 L TENSOR REMARK 3 L11: 0.0074 L22: -0.0013 REMARK 3 L33: 0.0023 L12: 0.0004 REMARK 3 L13: -0.0037 L23: -0.0022 REMARK 3 S TENSOR REMARK 3 S11: 0.0647 S12: -0.0579 S13: 0.0268 REMARK 3 S21: 0.0453 S22: 0.0393 S23: 0.0772 REMARK 3 S31: -0.0278 S32: 0.0823 S33: -0.0001 REMARK 3 TLS GROUP : 97 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 114 THROUGH 150 ) REMARK 3 ORIGIN FOR THE GROUP (A): 8.2664 24.5255 -41.2865 REMARK 3 T TENSOR REMARK 3 T11: 1.0031 T22: 1.8959 REMARK 3 T33: 0.9577 T12: 0.0649 REMARK 3 T13: 0.0764 T23: -0.0143 REMARK 3 L TENSOR REMARK 3 L11: 0.0208 L22: 0.0089 REMARK 3 L33: 0.0126 L12: -0.0011 REMARK 3 L13: 0.0252 L23: -0.0011 REMARK 3 S TENSOR REMARK 3 S11: 0.0215 S12: -0.1087 S13: 0.0723 REMARK 3 S21: 0.2521 S22: 0.0814 S23: 0.1880 REMARK 3 S31: 0.0274 S32: 0.0661 S33: 0.0000 REMARK 3 TLS GROUP : 98 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 151 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): 1.3194 26.9666 -41.0523 REMARK 3 T TENSOR REMARK 3 T11: 0.7677 T22: 1.0023 REMARK 3 T33: 1.1192 T12: 0.2291 REMARK 3 T13: -0.1214 T23: -0.0960 REMARK 3 L TENSOR REMARK 3 L11: 0.0268 L22: 0.0168 REMARK 3 L33: 0.0126 L12: -0.0256 REMARK 3 L13: -0.0227 L23: 0.0193 REMARK 3 S TENSOR REMARK 3 S11: -0.0093 S12: -0.1352 S13: -0.1480 REMARK 3 S21: 0.0623 S22: 0.0121 S23: 0.2099 REMARK 3 S31: -0.0148 S32: 0.1378 S33: -0.0000 REMARK 3 TLS GROUP : 99 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 173 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): 13.8473 30.4927 -41.5807 REMARK 3 T TENSOR REMARK 3 T11: 0.7419 T22: 1.1852 REMARK 3 T33: 1.0022 T12: -0.1748 REMARK 3 T13: -0.0437 T23: -0.0455 REMARK 3 L TENSOR REMARK 3 L11: 0.0077 L22: -0.0020 REMARK 3 L33: 0.0334 L12: 0.0049 REMARK 3 L13: 0.0117 L23: -0.0006 REMARK 3 S TENSOR REMARK 3 S11: 0.0941 S12: -0.0663 S13: 0.1460 REMARK 3 S21: 0.0004 S22: 0.1272 S23: -0.2399 REMARK 3 S31: 0.0287 S32: -0.1749 S33: 0.0001 REMARK 3 TLS GROUP : 100 REMARK 3 SELECTION: CHAIN 'F' AND (RESID 189 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): 11.3515 21.9970 -32.7803 REMARK 3 T TENSOR REMARK 3 T11: 0.8951 T22: 1.9226 REMARK 3 T33: 1.2565 T12: 0.0999 REMARK 3 T13: 0.0288 T23: 0.0103 REMARK 3 L TENSOR REMARK 3 L11: 0.0044 L22: -0.0019 REMARK 3 L33: 0.0142 L12: 0.0065 REMARK 3 L13: 0.0094 L23: 0.0109 REMARK 3 S TENSOR REMARK 3 S11: -0.0038 S12: 0.0090 S13: -0.0001 REMARK 3 S21: 0.0795 S22: -0.0594 S23: 0.0328 REMARK 3 S31: 0.0128 S32: 0.0431 S33: -0.0000 REMARK 3 TLS GROUP : 101 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -27.4080 97.1466 -61.9362 REMARK 3 T TENSOR REMARK 3 T11: 1.1401 T22: 0.6825 REMARK 3 T33: 0.7455 T12: -0.1101 REMARK 3 T13: 0.0918 T23: -0.0008 REMARK 3 L TENSOR REMARK 3 L11: 0.0048 L22: 0.0326 REMARK 3 L33: 0.0241 L12: 0.0168 REMARK 3 L13: -0.0121 L23: -0.0305 REMARK 3 S TENSOR REMARK 3 S11: -0.0909 S12: 0.0825 S13: -0.0707 REMARK 3 S21: -0.0190 S22: -0.2468 S23: -0.0072 REMARK 3 S31: -0.0238 S32: 0.1017 S33: 0.0000 REMARK 3 TLS GROUP : 102 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): -32.5013 86.6365 -63.7495 REMARK 3 T TENSOR REMARK 3 T11: 1.1865 T22: 0.4306 REMARK 3 T33: 0.6182 T12: -0.1615 REMARK 3 T13: 0.0094 T23: -0.1097 REMARK 3 L TENSOR REMARK 3 L11: 0.1905 L22: -0.0005 REMARK 3 L33: 0.2821 L12: 0.0307 REMARK 3 L13: -0.2300 L23: -0.0320 REMARK 3 S TENSOR REMARK 3 S11: 0.2311 S12: -0.1567 S13: 0.0654 REMARK 3 S21: -0.0970 S22: -0.2744 S23: 0.0255 REMARK 3 S31: -0.2685 S32: 0.2312 S33: -0.0615 REMARK 3 TLS GROUP : 103 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 44 THROUGH 71 ) REMARK 3 ORIGIN FOR THE GROUP (A): -38.9670 87.0380 -57.0403 REMARK 3 T TENSOR REMARK 3 T11: 0.4724 T22: 0.1412 REMARK 3 T33: 0.3477 T12: -0.2512 REMARK 3 T13: 0.2205 T23: 0.2921 REMARK 3 L TENSOR REMARK 3 L11: 0.0138 L22: 0.0505 REMARK 3 L33: 0.0363 L12: 0.0060 REMARK 3 L13: 0.0120 L23: 0.0296 REMARK 3 S TENSOR REMARK 3 S11: -0.0197 S12: 0.1166 S13: 0.1069 REMARK 3 S21: -0.0286 S22: 0.0156 S23: -0.0060 REMARK 3 S31: 0.0968 S32: -0.0996 S33: -0.1451 REMARK 3 TLS GROUP : 104 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 72 THROUGH 87 ) REMARK 3 ORIGIN FOR THE GROUP (A): -36.3080 95.8507 -62.0944 REMARK 3 T TENSOR REMARK 3 T11: 0.7989 T22: 0.6247 REMARK 3 T33: 0.8367 T12: -0.1706 REMARK 3 T13: -0.0039 T23: 0.0657 REMARK 3 L TENSOR REMARK 3 L11: 0.0020 L22: 0.0117 REMARK 3 L33: 0.0043 L12: -0.0004 REMARK 3 L13: -0.0039 L23: 0.0000 REMARK 3 S TENSOR REMARK 3 S11: -0.0658 S12: 0.1216 S13: 0.0020 REMARK 3 S21: -0.0108 S22: 0.0531 S23: 0.0063 REMARK 3 S31: 0.0324 S32: -0.0262 S33: 0.0000 REMARK 3 TLS GROUP : 105 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 88 THROUGH 99 ) REMARK 3 ORIGIN FOR THE GROUP (A): -27.0752 89.7183 -56.3007 REMARK 3 T TENSOR REMARK 3 T11: 0.8200 T22: 0.5041 REMARK 3 T33: 0.7079 T12: 0.0350 REMARK 3 T13: -0.1753 T23: 0.1535 REMARK 3 L TENSOR REMARK 3 L11: 0.0043 L22: 0.0017 REMARK 3 L33: 0.0029 L12: -0.0042 REMARK 3 L13: -0.0055 L23: 0.0119 REMARK 3 S TENSOR REMARK 3 S11: -0.0158 S12: 0.1667 S13: -0.1512 REMARK 3 S21: 0.0904 S22: -0.0917 S23: -0.0540 REMARK 3 S31: -0.0587 S32: -0.0885 S33: 0.0001 REMARK 3 TLS GROUP : 106 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 100 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): -10.5824 92.7291 -60.9698 REMARK 3 T TENSOR REMARK 3 T11: 0.6705 T22: 0.4600 REMARK 3 T33: 0.9494 T12: -0.1800 REMARK 3 T13: 0.1667 T23: -0.3320 REMARK 3 L TENSOR REMARK 3 L11: 0.0866 L22: 0.0683 REMARK 3 L33: 0.2165 L12: -0.0884 REMARK 3 L13: -0.0046 L23: 0.0085 REMARK 3 S TENSOR REMARK 3 S11: 0.1517 S12: 0.2560 S13: -0.0395 REMARK 3 S21: -0.0923 S22: 0.2222 S23: -0.1802 REMARK 3 S31: 0.2762 S32: 0.1126 S33: 0.1366 REMARK 3 TLS GROUP : 107 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 153 THROUGH 200 ) REMARK 3 ORIGIN FOR THE GROUP (A): -1.0702 94.5243 -62.5217 REMARK 3 T TENSOR REMARK 3 T11: 1.2294 T22: 0.6298 REMARK 3 T33: 1.1477 T12: -0.2287 REMARK 3 T13: 0.3167 T23: -0.1548 REMARK 3 L TENSOR REMARK 3 L11: 0.0252 L22: 0.0439 REMARK 3 L33: 0.0169 L12: -0.0304 REMARK 3 L13: 0.0151 L23: -0.0314 REMARK 3 S TENSOR REMARK 3 S11: -0.1053 S12: -0.0722 S13: 0.0070 REMARK 3 S21: -0.2337 S22: -0.5157 S23: 0.0384 REMARK 3 S31: -0.1795 S32: -0.0508 S33: 0.0000 REMARK 3 TLS GROUP : 108 REMARK 3 SELECTION: CHAIN 'H' AND (RESID 201 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -2.9238 102.9719 -65.4543 REMARK 3 T TENSOR REMARK 3 T11: 1.2104 T22: 0.5297 REMARK 3 T33: 1.2075 T12: -0.1287 REMARK 3 T13: -0.0672 T23: -0.2603 REMARK 3 L TENSOR REMARK 3 L11: 0.0273 L22: 0.0139 REMARK 3 L33: 0.1025 L12: -0.0207 REMARK 3 L13: 0.0522 L23: -0.0439 REMARK 3 S TENSOR REMARK 3 S11: -0.1203 S12: 0.0638 S13: 0.0549 REMARK 3 S21: 0.0343 S22: -0.1102 S23: 0.1624 REMARK 3 S31: -0.0531 S32: 0.1538 S33: -0.0083 REMARK 3 TLS GROUP : 109 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 1 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.8617 68.8425 -53.5444 REMARK 3 T TENSOR REMARK 3 T11: 0.4183 T22: 0.4439 REMARK 3 T33: 0.7602 T12: -0.2350 REMARK 3 T13: -0.0269 T23: 0.1149 REMARK 3 L TENSOR REMARK 3 L11: 0.0133 L22: 0.1368 REMARK 3 L33: 0.0237 L12: -0.0220 REMARK 3 L13: 0.0143 L23: 0.0535 REMARK 3 S TENSOR REMARK 3 S11: 0.0242 S12: -0.2002 S13: 0.2086 REMARK 3 S21: 0.1762 S22: -0.0775 S23: -0.0845 REMARK 3 S31: 0.1451 S32: 0.0709 S33: 0.0259 REMARK 3 TLS GROUP : 110 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 39 THROUGH 61 ) REMARK 3 ORIGIN FOR THE GROUP (A): -22.5191 71.9562 -66.5947 REMARK 3 T TENSOR REMARK 3 T11: 0.3981 T22: 0.2502 REMARK 3 T33: 0.6873 T12: 0.0021 REMARK 3 T13: 0.2602 T23: -0.0326 REMARK 3 L TENSOR REMARK 3 L11: 0.0415 L22: 0.0280 REMARK 3 L33: 0.0735 L12: 0.0490 REMARK 3 L13: -0.0542 L23: -0.0462 REMARK 3 S TENSOR REMARK 3 S11: 0.0721 S12: 0.0093 S13: -0.0133 REMARK 3 S21: -0.0525 S22: -0.1730 S23: 0.0588 REMARK 3 S31: 0.1408 S32: -0.0319 S33: -0.0218 REMARK 3 TLS GROUP : 111 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 62 THROUGH 102 ) REMARK 3 ORIGIN FOR THE GROUP (A): -23.0156 69.9913 -57.8187 REMARK 3 T TENSOR REMARK 3 T11: 0.5358 T22: 0.5085 REMARK 3 T33: 0.9047 T12: -0.2630 REMARK 3 T13: 0.1686 T23: 0.0912 REMARK 3 L TENSOR REMARK 3 L11: 0.0237 L22: 0.0082 REMARK 3 L33: 0.0671 L12: 0.0070 REMARK 3 L13: 0.0469 L23: 0.0011 REMARK 3 S TENSOR REMARK 3 S11: -0.0599 S12: 0.0414 S13: 0.0563 REMARK 3 S21: -0.0285 S22: -0.2569 S23: -0.1056 REMARK 3 S31: 0.1846 S32: -0.0713 S33: -0.1090 REMARK 3 TLS GROUP : 112 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 103 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -0.7441 72.5922 -56.1793 REMARK 3 T TENSOR REMARK 3 T11: 0.7395 T22: 0.3803 REMARK 3 T33: 1.0677 T12: -0.1205 REMARK 3 T13: -0.1413 T23: -0.0390 REMARK 3 L TENSOR REMARK 3 L11: 0.0004 L22: 0.0096 REMARK 3 L33: 0.0033 L12: 0.0060 REMARK 3 L13: 0.0006 L23: -0.0092 REMARK 3 S TENSOR REMARK 3 S11: 0.0011 S12: -0.0200 S13: -0.0524 REMARK 3 S21: 0.0019 S22: 0.0423 S23: 0.0146 REMARK 3 S31: 0.1311 S32: 0.0293 S33: 0.0000 REMARK 3 TLS GROUP : 113 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 114 THROUGH 139 ) REMARK 3 ORIGIN FOR THE GROUP (A): 7.5623 96.8976 -54.8430 REMARK 3 T TENSOR REMARK 3 T11: 0.9240 T22: 0.6428 REMARK 3 T33: 1.7122 T12: -0.1041 REMARK 3 T13: -0.2748 T23: -0.0416 REMARK 3 L TENSOR REMARK 3 L11: 0.0227 L22: 0.0024 REMARK 3 L33: 0.0060 L12: 0.0013 REMARK 3 L13: 0.0221 L23: -0.0019 REMARK 3 S TENSOR REMARK 3 S11: -0.0569 S12: 0.0012 S13: -0.0561 REMARK 3 S21: 0.0823 S22: -0.0410 S23: -0.0034 REMARK 3 S31: -0.2699 S32: 0.1009 S33: 0.0000 REMARK 3 TLS GROUP : 114 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 140 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): 4.2060 86.2353 -48.5859 REMARK 3 T TENSOR REMARK 3 T11: 1.0209 T22: 0.7490 REMARK 3 T33: 0.8991 T12: -0.1881 REMARK 3 T13: 0.1937 T23: -0.2247 REMARK 3 L TENSOR REMARK 3 L11: 0.0602 L22: 0.0402 REMARK 3 L33: 0.0170 L12: -0.0377 REMARK 3 L13: -0.0161 L23: -0.0181 REMARK 3 S TENSOR REMARK 3 S11: -0.3295 S12: 0.1551 S13: -0.1225 REMARK 3 S21: 0.2156 S22: -0.0905 S23: -0.1460 REMARK 3 S31: -0.0395 S32: 0.0774 S33: 0.0000 REMARK 3 TLS GROUP : 115 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 173 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): 7.0562 99.4571 -47.4659 REMARK 3 T TENSOR REMARK 3 T11: 0.7520 T22: 1.2539 REMARK 3 T33: 0.8210 T12: -0.2146 REMARK 3 T13: 0.0361 T23: -0.0320 REMARK 3 L TENSOR REMARK 3 L11: 0.0134 L22: 0.0033 REMARK 3 L33: -0.0029 L12: 0.0004 REMARK 3 L13: 0.0048 L23: 0.0109 REMARK 3 S TENSOR REMARK 3 S11: 0.1369 S12: -0.1418 S13: -0.0887 REMARK 3 S21: 0.0972 S22: 0.0932 S23: 0.0593 REMARK 3 S31: -0.2307 S32: 0.0647 S33: 0.0001 REMARK 3 TLS GROUP : 116 REMARK 3 SELECTION: CHAIN 'I' AND (RESID 189 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): 16.0073 90.8894 -48.8549 REMARK 3 T TENSOR REMARK 3 T11: 1.1394 T22: 1.1781 REMARK 3 T33: 1.7414 T12: 0.0914 REMARK 3 T13: -0.1676 T23: -0.0700 REMARK 3 L TENSOR REMARK 3 L11: 0.0252 L22: 0.0094 REMARK 3 L33: 0.0088 L12: -0.0170 REMARK 3 L13: 0.0158 L23: -0.0090 REMARK 3 S TENSOR REMARK 3 S11: 0.0965 S12: 0.0099 S13: -0.1115 REMARK 3 S21: -0.0150 S22: 0.0523 S23: -0.0030 REMARK 3 S31: 0.1380 S32: 0.0162 S33: 0.0000 REMARK 3 TLS GROUP : 117 REMARK 3 SELECTION: CHAIN 'K' AND (RESID 1 THROUGH 126 ) REMARK 3 ORIGIN FOR THE GROUP (A): -72.6274 90.5756 -32.0440 REMARK 3 T TENSOR REMARK 3 T11: 0.5719 T22: -0.3983 REMARK 3 T33: 0.2039 T12: 0.1116 REMARK 3 T13: -0.0371 T23: -0.4014 REMARK 3 L TENSOR REMARK 3 L11: 0.3219 L22: 0.0720 REMARK 3 L33: 0.0186 L12: 0.0419 REMARK 3 L13: -0.0761 L23: 0.0112 REMARK 3 S TENSOR REMARK 3 S11: 0.1650 S12: -0.3722 S13: 0.3691 REMARK 3 S21: -0.2632 S22: 0.0456 S23: -0.0929 REMARK 3 S31: -0.2613 S32: 0.0876 S33: 0.2440 REMARK 3 TLS GROUP : 118 REMARK 3 SELECTION: CHAIN 'K' AND (RESID 127 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -57.2868 118.3921 -13.1941 REMARK 3 T TENSOR REMARK 3 T11: 1.8228 T22: 1.7828 REMARK 3 T33: 2.3654 T12: -0.7203 REMARK 3 T13: 0.5394 T23: -0.8157 REMARK 3 L TENSOR REMARK 3 L11: 0.0233 L22: -0.0071 REMARK 3 L33: 0.0117 L12: 0.0051 REMARK 3 L13: 0.0335 L23: -0.0081 REMARK 3 S TENSOR REMARK 3 S11: -0.0728 S12: 0.0239 S13: 0.0101 REMARK 3 S21: 0.2402 S22: 0.0426 S23: -0.0728 REMARK 3 S31: -0.2822 S32: -0.1054 S33: 0.0000 REMARK 3 TLS GROUP : 119 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 1 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -50.4324 92.0435 -38.4555 REMARK 3 T TENSOR REMARK 3 T11: 0.1458 T22: -0.4683 REMARK 3 T33: 0.3443 T12: -0.5604 REMARK 3 T13: -0.0279 T23: -0.2626 REMARK 3 L TENSOR REMARK 3 L11: 0.1555 L22: 0.0270 REMARK 3 L33: 0.1989 L12: 0.0909 REMARK 3 L13: 0.0105 L23: 0.0129 REMARK 3 S TENSOR REMARK 3 S11: 0.1020 S12: -0.0285 S13: 0.0482 REMARK 3 S21: 0.0102 S22: -0.0170 S23: 0.1134 REMARK 3 S31: 0.0604 S32: 0.3021 S33: 0.0067 REMARK 3 TLS GROUP : 120 REMARK 3 SELECTION: CHAIN 'L' AND (RESID 114 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -46.2997 109.8875 -6.3939 REMARK 3 T TENSOR REMARK 3 T11: 2.0554 T22: 1.6200 REMARK 3 T33: 1.5290 T12: -0.7108 REMARK 3 T13: 0.2996 T23: -0.6909 REMARK 3 L TENSOR REMARK 3 L11: 0.0881 L22: 0.0285 REMARK 3 L33: 0.0897 L12: 0.0154 REMARK 3 L13: 0.0033 L23: -0.0208 REMARK 3 S TENSOR REMARK 3 S11: -0.2535 S12: 0.1224 S13: 0.2189 REMARK 3 S21: 0.1564 S22: 0.1830 S23: 0.0474 REMARK 3 S31: -0.0076 S32: 0.3665 S33: -0.0207 REMARK 3 TLS GROUP : 121 REMARK 3 SELECTION: CHAIN 'N' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -88.5392 40.7379 -14.8012 REMARK 3 T TENSOR REMARK 3 T11: 0.5184 T22: 0.4908 REMARK 3 T33: 0.4907 T12: 0.1114 REMARK 3 T13: 0.3286 T23: 0.0388 REMARK 3 L TENSOR REMARK 3 L11: 0.0497 L22: 0.0128 REMARK 3 L33: 0.0470 L12: 0.0209 REMARK 3 L13: 0.0405 L23: 0.0133 REMARK 3 S TENSOR REMARK 3 S11: 0.0163 S12: -0.0377 S13: 0.0206 REMARK 3 S21: 0.0560 S22: -0.0048 S23: -0.0383 REMARK 3 S31: 0.0443 S32: -0.1817 S33: 0.0876 REMARK 3 TLS GROUP : 122 REMARK 3 SELECTION: CHAIN 'N' AND (RESID 21 THROUGH 60 ) REMARK 3 ORIGIN FOR THE GROUP (A): -82.3617 45.2292 -26.2756 REMARK 3 T TENSOR REMARK 3 T11: 0.1287 T22: 0.3125 REMARK 3 T33: 0.2489 T12: 0.0614 REMARK 3 T13: 0.1056 T23: -0.0400 REMARK 3 L TENSOR REMARK 3 L11: 0.0717 L22: 0.3116 REMARK 3 L33: 0.1316 L12: 0.0502 REMARK 3 L13: 0.0451 L23: -0.1569 REMARK 3 S TENSOR REMARK 3 S11: 0.0718 S12: -0.1585 S13: -0.1243 REMARK 3 S21: -0.0326 S22: 0.1046 S23: -0.1255 REMARK 3 S31: -0.1158 S32: 0.1713 S33: 0.0360 REMARK 3 TLS GROUP : 123 REMARK 3 SELECTION: CHAIN 'N' AND (RESID 61 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): -81.5348 46.7461 -8.1573 REMARK 3 T TENSOR REMARK 3 T11: 0.3875 T22: 0.6720 REMARK 3 T33: 0.3133 T12: 0.0016 REMARK 3 T13: 0.0286 T23: -0.0798 REMARK 3 L TENSOR REMARK 3 L11: 0.1662 L22: 0.3073 REMARK 3 L33: 0.0907 L12: -0.2318 REMARK 3 L13: -0.0371 L23: -0.1566 REMARK 3 S TENSOR REMARK 3 S11: 0.1092 S12: -0.2106 S13: 0.0563 REMARK 3 S21: -0.0588 S22: 0.0579 S23: -0.3260 REMARK 3 S31: -0.2730 S32: -0.3894 S33: 0.0248 REMARK 3 TLS GROUP : 124 REMARK 3 SELECTION: CHAIN 'N' AND (RESID 153 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -85.9841 54.4717 13.8618 REMARK 3 T TENSOR REMARK 3 T11: 0.7588 T22: 0.8261 REMARK 3 T33: 0.3894 T12: -0.0921 REMARK 3 T13: 0.0294 T23: -0.0155 REMARK 3 L TENSOR REMARK 3 L11: 0.0478 L22: 0.0212 REMARK 3 L33: 0.0419 L12: -0.0098 REMARK 3 L13: 0.0271 L23: -0.0328 REMARK 3 S TENSOR REMARK 3 S11: 0.1187 S12: -0.4329 S13: -0.0535 REMARK 3 S21: -0.1659 S22: 0.2116 S23: 0.3329 REMARK 3 S31: -0.0259 S32: -0.3065 S33: 0.0022 REMARK 3 TLS GROUP : 125 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 1 THROUGH 17 ) REMARK 3 ORIGIN FOR THE GROUP (A): -69.8435 65.1253 -14.2126 REMARK 3 T TENSOR REMARK 3 T11: 0.6092 T22: 0.3853 REMARK 3 T33: 0.3526 T12: 0.0883 REMARK 3 T13: 0.0784 T23: -0.0927 REMARK 3 L TENSOR REMARK 3 L11: 0.1456 L22: 0.1515 REMARK 3 L33: 0.0141 L12: -0.0505 REMARK 3 L13: 0.0274 L23: 0.0157 REMARK 3 S TENSOR REMARK 3 S11: -0.1135 S12: -0.0295 S13: 0.2046 REMARK 3 S21: -0.0210 S22: -0.3351 S23: 0.0286 REMARK 3 S31: -0.0226 S32: 0.1626 S33: -0.0358 REMARK 3 TLS GROUP : 126 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 18 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): -70.7018 63.1980 -23.1873 REMARK 3 T TENSOR REMARK 3 T11: 0.3416 T22: 0.4710 REMARK 3 T33: 0.1571 T12: -0.1105 REMARK 3 T13: 0.1740 T23: -0.1646 REMARK 3 L TENSOR REMARK 3 L11: 0.0756 L22: 0.1603 REMARK 3 L33: 0.4056 L12: 0.0879 REMARK 3 L13: -0.0365 L23: -0.2080 REMARK 3 S TENSOR REMARK 3 S11: -0.0961 S12: -0.1303 S13: -0.0770 REMARK 3 S21: 0.0492 S22: -0.2369 S23: -0.0859 REMARK 3 S31: -0.0687 S32: 0.1717 S33: -0.3806 REMARK 3 TLS GROUP : 127 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 39 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -76.9277 65.1466 -19.0367 REMARK 3 T TENSOR REMARK 3 T11: 0.3827 T22: 0.1911 REMARK 3 T33: 0.1226 T12: 0.0479 REMARK 3 T13: 0.0319 T23: -0.1755 REMARK 3 L TENSOR REMARK 3 L11: -0.0062 L22: 0.0210 REMARK 3 L33: 0.0368 L12: 0.0294 REMARK 3 L13: 0.0053 L23: -0.0171 REMARK 3 S TENSOR REMARK 3 S11: 0.0077 S12: -0.0740 S13: 0.0866 REMARK 3 S21: 0.1420 S22: -0.2876 S23: 0.3062 REMARK 3 S31: -0.1769 S32: -0.0047 S33: -0.5228 REMARK 3 TLS GROUP : 128 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 114 THROUGH 139 ) REMARK 3 ORIGIN FOR THE GROUP (A): -74.4994 54.5890 18.6400 REMARK 3 T TENSOR REMARK 3 T11: 1.0762 T22: 1.1125 REMARK 3 T33: 0.6281 T12: 0.1352 REMARK 3 T13: 0.0191 T23: 0.0082 REMARK 3 L TENSOR REMARK 3 L11: -0.0037 L22: 0.0014 REMARK 3 L33: 0.0003 L12: -0.0001 REMARK 3 L13: 0.0093 L23: -0.0120 REMARK 3 S TENSOR REMARK 3 S11: -0.0400 S12: -0.3009 S13: -0.3554 REMARK 3 S21: 0.0012 S22: 0.0597 S23: 0.0228 REMARK 3 S31: -0.0077 S32: -0.0258 S33: -0.0000 REMARK 3 TLS GROUP : 129 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 140 THROUGH 150 ) REMARK 3 ORIGIN FOR THE GROUP (A): -64.8882 61.4278 8.9893 REMARK 3 T TENSOR REMARK 3 T11: 1.3849 T22: 1.1791 REMARK 3 T33: 0.6985 T12: -0.2498 REMARK 3 T13: 0.0140 T23: 0.0285 REMARK 3 L TENSOR REMARK 3 L11: 0.0093 L22: 0.0098 REMARK 3 L33: 0.0095 L12: 0.0031 REMARK 3 L13: 0.0083 L23: 0.0108 REMARK 3 S TENSOR REMARK 3 S11: -0.0461 S12: -0.1824 S13: -0.0661 REMARK 3 S21: -0.1138 S22: -0.1086 S23: -0.0163 REMARK 3 S31: -0.0949 S32: -0.0312 S33: -0.0000 REMARK 3 TLS GROUP : 130 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 151 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): -70.4912 58.2866 8.1703 REMARK 3 T TENSOR REMARK 3 T11: 0.8111 T22: 1.2241 REMARK 3 T33: 0.6219 T12: 0.0339 REMARK 3 T13: 0.0584 T23: -0.1758 REMARK 3 L TENSOR REMARK 3 L11: 0.0113 L22: 0.0136 REMARK 3 L33: 0.0116 L12: 0.0022 REMARK 3 L13: -0.0124 L23: 0.0019 REMARK 3 S TENSOR REMARK 3 S11: 0.0802 S12: -0.1176 S13: 0.0108 REMARK 3 S21: 0.0353 S22: 0.0159 S23: -0.0454 REMARK 3 S31: 0.0774 S32: 0.0827 S33: 0.0000 REMARK 3 TLS GROUP : 131 REMARK 3 SELECTION: CHAIN 'O' AND (RESID 173 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -65.9998 56.1192 19.2297 REMARK 3 T TENSOR REMARK 3 T11: 0.9645 T22: 1.0245 REMARK 3 T33: 0.5349 T12: -0.1497 REMARK 3 T13: -0.4374 T23: -0.0399 REMARK 3 L TENSOR REMARK 3 L11: 0.0874 L22: -0.0026 REMARK 3 L33: 0.1827 L12: 0.0183 REMARK 3 L13: 0.1261 L23: 0.0149 REMARK 3 S TENSOR REMARK 3 S11: -0.1787 S12: -0.1296 S13: 0.1751 REMARK 3 S21: -0.0180 S22: -0.0294 S23: -0.1855 REMARK 3 S31: -0.0081 S32: 0.2062 S33: -0.2102 REMARK 3 TLS GROUP : 132 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): 33.2109 -56.5726 -76.0554 REMARK 3 T TENSOR REMARK 3 T11: 0.5946 T22: 0.8941 REMARK 3 T33: 0.7397 T12: 0.0629 REMARK 3 T13: 0.1691 T23: -0.1953 REMARK 3 L TENSOR REMARK 3 L11: 0.0304 L22: 0.0065 REMARK 3 L33: 0.0026 L12: -0.0135 REMARK 3 L13: -0.0050 L23: 0.0002 REMARK 3 S TENSOR REMARK 3 S11: -0.0590 S12: -0.0775 S13: 0.2163 REMARK 3 S21: -0.0081 S22: -0.0128 S23: -0.1246 REMARK 3 S31: 0.1173 S32: -0.0216 S33: 0.0000 REMARK 3 TLS GROUP : 133 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): 26.1137 -51.3735 -68.2840 REMARK 3 T TENSOR REMARK 3 T11: 0.3913 T22: 0.9085 REMARK 3 T33: 0.4365 T12: 0.1436 REMARK 3 T13: -0.0341 T23: 0.1346 REMARK 3 L TENSOR REMARK 3 L11: 0.0136 L22: 0.1898 REMARK 3 L33: -0.0009 L12: 0.0422 REMARK 3 L13: -0.0044 L23: -0.0024 REMARK 3 S TENSOR REMARK 3 S11: -0.0879 S12: -0.1017 S13: -0.0797 REMARK 3 S21: -0.2296 S22: 0.1787 S23: -0.2123 REMARK 3 S31: -0.0185 S32: 0.0785 S33: 0.0071 REMARK 3 TLS GROUP : 134 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 44 THROUGH 71 ) REMARK 3 ORIGIN FOR THE GROUP (A): 19.1925 -57.6628 -68.0416 REMARK 3 T TENSOR REMARK 3 T11: 0.5173 T22: 0.5469 REMARK 3 T33: 0.3908 T12: 0.4740 REMARK 3 T13: 0.0817 T23: 0.2598 REMARK 3 L TENSOR REMARK 3 L11: 0.0777 L22: 0.0606 REMARK 3 L33: 0.0068 L12: -0.0624 REMARK 3 L13: -0.0283 L23: 0.0180 REMARK 3 S TENSOR REMARK 3 S11: 0.1130 S12: 0.0934 S13: -0.0368 REMARK 3 S21: -0.0578 S22: -0.1235 S23: 0.0051 REMARK 3 S31: -0.0463 S32: -0.0479 S33: -0.0205 REMARK 3 TLS GROUP : 135 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 72 THROUGH 99 ) REMARK 3 ORIGIN FOR THE GROUP (A): 27.2963 -57.3979 -73.0896 REMARK 3 T TENSOR REMARK 3 T11: 0.3828 T22: 1.2075 REMARK 3 T33: 0.4563 T12: 0.5605 REMARK 3 T13: 0.2281 T23: 0.0415 REMARK 3 L TENSOR REMARK 3 L11: 0.0527 L22: 0.0274 REMARK 3 L33: 0.0285 L12: -0.0037 REMARK 3 L13: -0.0373 L23: 0.0217 REMARK 3 S TENSOR REMARK 3 S11: 0.1369 S12: 0.0092 S13: 0.0295 REMARK 3 S21: -0.1165 S22: -0.0218 S23: -0.0876 REMARK 3 S31: 0.0575 S32: 0.1284 S33: 0.1026 REMARK 3 TLS GROUP : 136 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 100 THROUGH 126 ) REMARK 3 ORIGIN FOR THE GROUP (A): 27.9183 -50.6231 -75.8080 REMARK 3 T TENSOR REMARK 3 T11: 0.4619 T22: 0.7271 REMARK 3 T33: 0.8561 T12: 0.2291 REMARK 3 T13: 0.6179 T23: 0.0427 REMARK 3 L TENSOR REMARK 3 L11: 0.1115 L22: 0.1264 REMARK 3 L33: 0.1758 L12: 0.0516 REMARK 3 L13: -0.1269 L23: 0.0687 REMARK 3 S TENSOR REMARK 3 S11: 0.0953 S12: 0.2636 S13: 0.0729 REMARK 3 S21: 0.2381 S22: 0.0785 S23: 0.0550 REMARK 3 S31: -0.1189 S32: 0.1796 S33: -0.0808 REMARK 3 TLS GROUP : 137 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 127 THROUGH 169 ) REMARK 3 ORIGIN FOR THE GROUP (A): 38.3697 -40.4054-105.2616 REMARK 3 T TENSOR REMARK 3 T11: 1.3865 T22: 1.2370 REMARK 3 T33: 1.2983 T12: 0.2699 REMARK 3 T13: 0.1516 T23: 0.4658 REMARK 3 L TENSOR REMARK 3 L11: 0.0128 L22: 0.0075 REMARK 3 L33: 0.0089 L12: 0.0111 REMARK 3 L13: 0.0165 L23: -0.0025 REMARK 3 S TENSOR REMARK 3 S11: -0.3141 S12: -0.0969 S13: 0.1868 REMARK 3 S21: -0.3395 S22: -0.0445 S23: 0.0564 REMARK 3 S31: -0.1975 S32: 0.1587 S33: -0.0000 REMARK 3 TLS GROUP : 138 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 170 THROUGH 180 ) REMARK 3 ORIGIN FOR THE GROUP (A): 29.7837 -46.6400 -98.5992 REMARK 3 T TENSOR REMARK 3 T11: 1.7171 T22: 1.3803 REMARK 3 T33: 1.1876 T12: -0.1543 REMARK 3 T13: 0.0963 T23: 0.4036 REMARK 3 L TENSOR REMARK 3 L11: 0.0045 L22: 0.0059 REMARK 3 L33: 0.0116 L12: 0.0019 REMARK 3 L13: 0.0026 L23: -0.0083 REMARK 3 S TENSOR REMARK 3 S11: -0.1150 S12: 0.0545 S13: -0.0391 REMARK 3 S21: 0.0220 S22: -0.0928 S23: 0.0408 REMARK 3 S31: 0.1324 S32: 0.0448 S33: 0.0000 REMARK 3 TLS GROUP : 139 REMARK 3 SELECTION: CHAIN 'G' AND (RESID 181 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): 42.3575 -41.4810-105.1787 REMARK 3 T TENSOR REMARK 3 T11: 1.4611 T22: 1.4318 REMARK 3 T33: 1.1482 T12: 0.0366 REMARK 3 T13: 0.5633 T23: 0.4380 REMARK 3 L TENSOR REMARK 3 L11: 0.0111 L22: 0.0270 REMARK 3 L33: 0.0138 L12: -0.0029 REMARK 3 L13: 0.0030 L23: 0.0210 REMARK 3 S TENSOR REMARK 3 S11: -0.0235 S12: 0.2418 S13: 0.0931 REMARK 3 S21: 0.3354 S22: -0.0196 S23: -0.0913 REMARK 3 S31: 0.1683 S32: 0.0381 S33: -0.0000 REMARK 3 TLS GROUP : 140 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 1 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): 12.1436 -35.2893 -77.1614 REMARK 3 T TENSOR REMARK 3 T11: 0.8344 T22: 0.7294 REMARK 3 T33: 0.5434 T12: 0.0440 REMARK 3 T13: 0.2424 T23: 0.1961 REMARK 3 L TENSOR REMARK 3 L11: 0.0462 L22: 0.0436 REMARK 3 L33: 0.0189 L12: -0.0306 REMARK 3 L13: 0.0297 L23: 0.0073 REMARK 3 S TENSOR REMARK 3 S11: -0.0875 S12: -0.0642 S13: 0.0624 REMARK 3 S21: -0.2849 S22: 0.1428 S23: 0.2716 REMARK 3 S31: -0.0811 S32: -0.0645 S33: -0.0024 REMARK 3 TLS GROUP : 141 REMARK 3 SELECTION: CHAIN 'J' AND (RESID 39 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): 22.1988 -37.9170 -95.7814 REMARK 3 T TENSOR REMARK 3 T11: 0.7825 T22: 0.3873 REMARK 3 T33: -0.5683 T12: 0.4427 REMARK 3 T13: 0.0455 T23: 0.5513 REMARK 3 L TENSOR REMARK 3 L11: 0.0716 L22: 0.3082 REMARK 3 L33: 0.0002 L12: 0.0142 REMARK 3 L13: -0.0532 L23: -0.0588 REMARK 3 S TENSOR REMARK 3 S11: 0.1633 S12: 0.6766 S13: -0.4373 REMARK 3 S21: -1.0252 S22: -0.0666 S23: -0.2645 REMARK 3 S31: 0.0147 S32: 0.3563 S33: 0.0961 REMARK 3 TLS GROUP : 142 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -10.2577 -95.1373 -62.5791 REMARK 3 T TENSOR REMARK 3 T11: 0.7649 T22: 0.6066 REMARK 3 T33: 1.1879 T12: 0.2326 REMARK 3 T13: 0.0616 T23: 0.1311 REMARK 3 L TENSOR REMARK 3 L11: 0.0021 L22: 0.0672 REMARK 3 L33: 0.0127 L12: -0.0159 REMARK 3 L13: -0.0037 L23: 0.0040 REMARK 3 S TENSOR REMARK 3 S11: -0.0667 S12: -0.0484 S13: 0.1058 REMARK 3 S21: 0.0798 S22: 0.0697 S23: -0.1390 REMARK 3 S31: 0.0096 S32: 0.0142 S33: 0.0000 REMARK 3 TLS GROUP : 143 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): -6.0215 -85.0095 -58.3789 REMARK 3 T TENSOR REMARK 3 T11: 0.8317 T22: 0.5638 REMARK 3 T33: 0.3545 T12: 0.2206 REMARK 3 T13: -0.0307 T23: 0.0252 REMARK 3 L TENSOR REMARK 3 L11: 0.0139 L22: 0.0296 REMARK 3 L33: 0.0042 L12: 0.0048 REMARK 3 L13: -0.0070 L23: -0.0013 REMARK 3 S TENSOR REMARK 3 S11: 0.0569 S12: -0.0098 S13: -0.4226 REMARK 3 S21: -0.2248 S22: -0.0954 S23: 0.1289 REMARK 3 S31: -0.1411 S32: 0.1109 S33: -0.0000 REMARK 3 TLS GROUP : 144 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 44 THROUGH 60 ) REMARK 3 ORIGIN FOR THE GROUP (A): -11.1499 -79.5611 -55.1976 REMARK 3 T TENSOR REMARK 3 T11: 0.6807 T22: 0.2602 REMARK 3 T33: 0.3074 T12: 0.3093 REMARK 3 T13: -0.1444 T23: -0.1148 REMARK 3 L TENSOR REMARK 3 L11: 0.0940 L22: 0.0401 REMARK 3 L33: 0.0015 L12: -0.0292 REMARK 3 L13: -0.0049 L23: 0.0118 REMARK 3 S TENSOR REMARK 3 S11: -0.1619 S12: -0.1198 S13: 0.0003 REMARK 3 S21: 0.0334 S22: 0.1031 S23: -0.0182 REMARK 3 S31: 0.0568 S32: -0.0097 S33: 0.0289 REMARK 3 TLS GROUP : 145 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 61 THROUGH 87 ) REMARK 3 ORIGIN FOR THE GROUP (A): -15.8504 -87.0225 -57.8418 REMARK 3 T TENSOR REMARK 3 T11: 1.0318 T22: 0.3596 REMARK 3 T33: 0.7274 T12: 0.4437 REMARK 3 T13: 0.0074 T23: 0.0112 REMARK 3 L TENSOR REMARK 3 L11: 0.0645 L22: 0.0423 REMARK 3 L33: 0.1325 L12: -0.0199 REMARK 3 L13: -0.0855 L23: 0.0003 REMARK 3 S TENSOR REMARK 3 S11: -0.1144 S12: -0.1042 S13: -0.0017 REMARK 3 S21: 0.1627 S22: -0.0338 S23: 0.1854 REMARK 3 S31: 0.0902 S32: 0.0676 S33: -0.0126 REMARK 3 TLS GROUP : 146 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 88 THROUGH 126 ) REMARK 3 ORIGIN FOR THE GROUP (A): -7.4636 -88.1589 -65.6609 REMARK 3 T TENSOR REMARK 3 T11: 0.9306 T22: 0.7053 REMARK 3 T33: 0.8816 T12: 0.1993 REMARK 3 T13: -0.0036 T23: 0.0317 REMARK 3 L TENSOR REMARK 3 L11: 0.0309 L22: 0.0223 REMARK 3 L33: 0.0726 L12: -0.0207 REMARK 3 L13: -0.0509 L23: 0.0496 REMARK 3 S TENSOR REMARK 3 S11: 0.3381 S12: -0.0422 S13: 0.0854 REMARK 3 S21: -0.0549 S22: 0.4375 S23: -0.1590 REMARK 3 S31: -0.1029 S32: 0.0221 S33: 0.0091 REMARK 3 TLS GROUP : 147 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 127 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): 0.8537-105.6261 -97.1809 REMARK 3 T TENSOR REMARK 3 T11: 1.0040 T22: 0.8785 REMARK 3 T33: 1.0580 T12: 0.3282 REMARK 3 T13: 0.0457 T23: 0.1394 REMARK 3 L TENSOR REMARK 3 L11: 0.0047 L22: 0.0149 REMARK 3 L33: 0.0016 L12: -0.0050 REMARK 3 L13: -0.0078 L23: -0.0017 REMARK 3 S TENSOR REMARK 3 S11: 0.0623 S12: 0.0556 S13: -0.0590 REMARK 3 S21: -0.0751 S22: 0.2515 S23: 0.0718 REMARK 3 S31: -0.0626 S32: -0.0016 S33: -0.0000 REMARK 3 TLS GROUP : 148 REMARK 3 SELECTION: CHAIN 'Q' AND (RESID 153 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): 0.6767-105.8932 -87.6146 REMARK 3 T TENSOR REMARK 3 T11: 0.9751 T22: 1.0799 REMARK 3 T33: 0.9664 T12: 0.1750 REMARK 3 T13: 0.0701 T23: -0.1718 REMARK 3 L TENSOR REMARK 3 L11: 0.0096 L22: -0.0037 REMARK 3 L33: 0.0229 L12: -0.0177 REMARK 3 L13: 0.0068 L23: -0.0094 REMARK 3 S TENSOR REMARK 3 S11: -0.0837 S12: -0.0505 S13: -0.1556 REMARK 3 S21: 0.1037 S22: -0.4130 S23: -0.0965 REMARK 3 S31: 0.3020 S32: -0.0603 S33: -0.0001 REMARK 3 TLS GROUP : 149 REMARK 3 SELECTION: CHAIN 'R' AND (RESID 1 THROUGH 17 ) REMARK 3 ORIGIN FOR THE GROUP (A): 1.7462 -72.2530 -79.2799 REMARK 3 T TENSOR REMARK 3 T11: 0.3148 T22: 1.0741 REMARK 3 T33: 0.7297 T12: 0.2670 REMARK 3 T13: -0.0198 T23: 0.1437 REMARK 3 L TENSOR REMARK 3 L11: 0.0060 L22: 0.0294 REMARK 3 L33: 0.0177 L12: 0.0119 REMARK 3 L13: -0.0026 L23: -0.0185 REMARK 3 S TENSOR REMARK 3 S11: -0.1297 S12: -0.0335 S13: 0.0073 REMARK 3 S21: -0.1741 S22: -0.0501 S23: -0.0041 REMARK 3 S31: 0.0214 S32: -0.1043 S33: 0.0017 REMARK 3 TLS GROUP : 150 REMARK 3 SELECTION: CHAIN 'R' AND (RESID 18 THROUGH 102 ) REMARK 3 ORIGIN FOR THE GROUP (A): 4.2615 -72.8512 -69.3532 REMARK 3 T TENSOR REMARK 3 T11: 0.0746 T22: 0.2177 REMARK 3 T33: 0.1072 T12: 0.6673 REMARK 3 T13: 0.2253 T23: -0.0387 REMARK 3 L TENSOR REMARK 3 L11: 0.2364 L22: 0.3029 REMARK 3 L33: 0.0203 L12: 0.2261 REMARK 3 L13: 0.0308 L23: 0.0629 REMARK 3 S TENSOR REMARK 3 S11: 0.0795 S12: 0.0757 S13: 0.1614 REMARK 3 S21: 0.0069 S22: 0.0066 S23: 0.0723 REMARK 3 S31: 0.0762 S32: 0.1408 S33: -0.1235 REMARK 3 TLS GROUP : 151 REMARK 3 SELECTION: CHAIN 'R' AND (RESID 103 THROUGH 128 ) REMARK 3 ORIGIN FOR THE GROUP (A): 1.2552 -95.7364 -95.5638 REMARK 3 T TENSOR REMARK 3 T11: 1.2213 T22: 1.0842 REMARK 3 T33: 0.8009 T12: 0.1409 REMARK 3 T13: -0.0831 T23: 0.0544 REMARK 3 L TENSOR REMARK 3 L11: 0.0117 L22: 0.0104 REMARK 3 L33: 0.0154 L12: -0.0147 REMARK 3 L13: 0.0380 L23: -0.0089 REMARK 3 S TENSOR REMARK 3 S11: 0.0504 S12: 0.0237 S13: -0.1279 REMARK 3 S21: -0.0430 S22: 0.2130 S23: 0.0809 REMARK 3 S31: -0.1521 S32: 0.1262 S33: 0.0000 REMARK 3 TLS GROUP : 152 REMARK 3 SELECTION: CHAIN 'R' AND (RESID 129 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -3.9194 -94.0961-101.1076 REMARK 3 T TENSOR REMARK 3 T11: 1.3125 T22: 1.2776 REMARK 3 T33: 0.5372 T12: 0.3006 REMARK 3 T13: -0.1458 T23: 0.0022 REMARK 3 L TENSOR REMARK 3 L11: 0.0623 L22: 0.0519 REMARK 3 L33: 0.0382 L12: -0.0218 REMARK 3 L13: -0.0210 L23: 0.0522 REMARK 3 S TENSOR REMARK 3 S11: -0.1421 S12: 0.1365 S13: 0.1073 REMARK 3 S21: -0.4139 S22: 0.2295 S23: 0.2480 REMARK 3 S31: 0.1944 S32: -0.1593 S33: 0.0054 REMARK 3 TLS GROUP : 153 REMARK 3 SELECTION: CHAIN 'T' AND (RESID 1 THROUGH 60 ) REMARK 3 ORIGIN FOR THE GROUP (A): -48.7316 -62.1762 -42.8325 REMARK 3 T TENSOR REMARK 3 T11: 0.2947 T22: 0.2387 REMARK 3 T33: 0.7717 T12: -0.0101 REMARK 3 T13: -0.1236 T23: 0.0193 REMARK 3 L TENSOR REMARK 3 L11: 0.0234 L22: 0.0314 REMARK 3 L33: 0.0635 L12: -0.0005 REMARK 3 L13: -0.0330 L23: -0.0381 REMARK 3 S TENSOR REMARK 3 S11: -0.0947 S12: 0.1279 S13: 0.1347 REMARK 3 S21: -0.1001 S22: -0.1062 S23: 0.3653 REMARK 3 S31: -0.0967 S32: 0.0048 S33: -0.0961 REMARK 3 TLS GROUP : 154 REMARK 3 SELECTION: CHAIN 'T' AND (RESID 61 THROUGH 126 ) REMARK 3 ORIGIN FOR THE GROUP (A): -51.4489 -61.9401 -46.0761 REMARK 3 T TENSOR REMARK 3 T11: 0.3304 T22: 0.5160 REMARK 3 T33: 1.1973 T12: 0.0481 REMARK 3 T13: -0.2792 T23: -0.0862 REMARK 3 L TENSOR REMARK 3 L11: 0.0105 L22: 0.0021 REMARK 3 L33: 0.0082 L12: 0.0052 REMARK 3 L13: 0.0040 L23: 0.0330 REMARK 3 S TENSOR REMARK 3 S11: 0.1569 S12: -0.3424 S13: -0.2307 REMARK 3 S21: 0.0366 S22: -0.0993 S23: 0.2172 REMARK 3 S31: 0.0419 S32: -0.1993 S33: 0.0727 REMARK 3 TLS GROUP : 155 REMARK 3 SELECTION: CHAIN 'T' AND (RESID 127 THROUGH 152 ) REMARK 3 ORIGIN FOR THE GROUP (A): -70.2177 -91.9836 -62.5515 REMARK 3 T TENSOR REMARK 3 T11: 1.3265 T22: 1.0890 REMARK 3 T33: 1.3004 T12: -0.2923 REMARK 3 T13: 0.1856 T23: -0.5059 REMARK 3 L TENSOR REMARK 3 L11: 0.0102 L22: 0.0018 REMARK 3 L33: 0.0141 L12: -0.0022 REMARK 3 L13: -0.0024 L23: -0.0068 REMARK 3 S TENSOR REMARK 3 S11: 0.0021 S12: -0.0973 S13: -0.0865 REMARK 3 S21: 0.0163 S22: -0.0987 S23: 0.0458 REMARK 3 S31: -0.0787 S32: -0.0137 S33: 0.0000 REMARK 3 TLS GROUP : 156 REMARK 3 SELECTION: CHAIN 'T' AND (RESID 153 THROUGH 180 ) REMARK 3 ORIGIN FOR THE GROUP (A): -63.5621 -82.2958 -56.2508 REMARK 3 T TENSOR REMARK 3 T11: 1.4346 T22: 1.1061 REMARK 3 T33: 1.0081 T12: -0.2239 REMARK 3 T13: -0.1152 T23: -0.1357 REMARK 3 L TENSOR REMARK 3 L11: 0.0007 L22: 0.0128 REMARK 3 L33: 0.0139 L12: -0.0081 REMARK 3 L13: 0.0022 L23: 0.0177 REMARK 3 S TENSOR REMARK 3 S11: 0.0649 S12: -0.1905 S13: 0.1427 REMARK 3 S21: -0.0051 S22: 0.0298 S23: -0.0160 REMARK 3 S31: 0.1197 S32: 0.0752 S33: 0.0000 REMARK 3 TLS GROUP : 157 REMARK 3 SELECTION: CHAIN 'T' AND (RESID 181 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -69.4346 -89.6635 -54.7512 REMARK 3 T TENSOR REMARK 3 T11: 1.2127 T22: 0.7804 REMARK 3 T33: 1.3640 T12: -0.0438 REMARK 3 T13: 0.2300 T23: -0.2013 REMARK 3 L TENSOR REMARK 3 L11: 0.0356 L22: 0.0107 REMARK 3 L33: 0.0269 L12: -0.0035 REMARK 3 L13: 0.0225 L23: -0.0162 REMARK 3 S TENSOR REMARK 3 S11: -0.3210 S12: -0.0489 S13: 0.1245 REMARK 3 S21: -0.0488 S22: -0.1093 S23: 0.0071 REMARK 3 S31: 0.2954 S32: -0.0160 S33: -0.0000 REMARK 3 TLS GROUP : 158 REMARK 3 SELECTION: CHAIN 'U' AND (RESID 1 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): -34.4706 -70.3198 -61.5830 REMARK 3 T TENSOR REMARK 3 T11: 0.6740 T22: 0.4829 REMARK 3 T33: 0.4947 T12: 0.1558 REMARK 3 T13: 0.0383 T23: -0.0364 REMARK 3 L TENSOR REMARK 3 L11: 0.0000 L22: 0.0019 REMARK 3 L33: 0.0263 L12: 0.0069 REMARK 3 L13: 0.0137 L23: 0.0211 REMARK 3 S TENSOR REMARK 3 S11: 0.0137 S12: 0.3704 S13: 0.1728 REMARK 3 S21: -0.0860 S22: -0.1629 S23: -0.0255 REMARK 3 S31: 0.0403 S32: 0.0222 S33: -0.0000 REMARK 3 TLS GROUP : 159 REMARK 3 SELECTION: CHAIN 'U' AND (RESID 39 THROUGH 102 ) REMARK 3 ORIGIN FOR THE GROUP (A): -34.8212 -73.4175 -54.4507 REMARK 3 T TENSOR REMARK 3 T11: 0.5557 T22: -0.0403 REMARK 3 T33: 0.5581 T12: 0.3315 REMARK 3 T13: -0.1877 T23: -0.2233 REMARK 3 L TENSOR REMARK 3 L11: 0.0142 L22: -0.0023 REMARK 3 L33: 0.0174 L12: -0.0124 REMARK 3 L13: -0.0018 L23: -0.0095 REMARK 3 S TENSOR REMARK 3 S11: 0.0071 S12: 0.0072 S13: -0.1299 REMARK 3 S21: 0.1082 S22: -0.0251 S23: 0.2878 REMARK 3 S31: 0.1540 S32: 0.0014 S33: -0.0690 REMARK 3 TLS GROUP : 160 REMARK 3 SELECTION: CHAIN 'U' AND (RESID 103 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): -61.4875 -86.3308 -70.2456 REMARK 3 T TENSOR REMARK 3 T11: 1.2959 T22: 1.4121 REMARK 3 T33: 1.0976 T12: -0.1702 REMARK 3 T13: -0.0223 T23: -0.2053 REMARK 3 L TENSOR REMARK 3 L11: 0.0202 L22: 0.0446 REMARK 3 L33: 0.0630 L12: -0.0266 REMARK 3 L13: -0.0082 L23: -0.0281 REMARK 3 S TENSOR REMARK 3 S11: 0.1746 S12: 0.1576 S13: 0.0495 REMARK 3 S21: 0.0557 S22: 0.2400 S23: -0.0279 REMARK 3 S31: 0.0356 S32: -0.2059 S33: 0.0001 REMARK 3 TLS GROUP : 161 REMARK 3 SELECTION: CHAIN 'U' AND (RESID 173 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -70.4028 -88.9377 -75.6933 REMARK 3 T TENSOR REMARK 3 T11: 1.2770 T22: 1.1182 REMARK 3 T33: 0.9904 T12: -0.1915 REMARK 3 T13: -0.4681 T23: -0.3375 REMARK 3 L TENSOR REMARK 3 L11: -0.0011 L22: 0.1437 REMARK 3 L33: 0.0892 L12: -0.0154 REMARK 3 L13: 0.0189 L23: -0.1187 REMARK 3 S TENSOR REMARK 3 S11: -0.0826 S12: 0.2292 S13: 0.0431 REMARK 3 S21: -0.1203 S22: -0.2137 S23: -0.1517 REMARK 3 S31: 0.0736 S32: -0.1525 S33: -0.0318 REMARK 3 TLS GROUP : 162 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 1 THROUGH 20 ) REMARK 3 ORIGIN FOR THE GROUP (A): -44.6131 -6.9701 -46.0417 REMARK 3 T TENSOR REMARK 3 T11: 0.3738 T22: 0.1818 REMARK 3 T33: 0.8316 T12: 0.0946 REMARK 3 T13: 0.1065 T23: -0.2519 REMARK 3 L TENSOR REMARK 3 L11: 0.2016 L22: 0.1321 REMARK 3 L33: 0.2456 L12: 0.0869 REMARK 3 L13: 0.0130 L23: -0.0867 REMARK 3 S TENSOR REMARK 3 S11: -0.4516 S12: -0.1877 S13: 0.0628 REMARK 3 S21: 0.1842 S22: -0.0617 S23: -0.0065 REMARK 3 S31: 0.1037 S32: -0.0783 S33: -0.2153 REMARK 3 TLS GROUP : 163 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 21 THROUGH 43 ) REMARK 3 ORIGIN FOR THE GROUP (A): -39.0831 -16.9665 -43.2080 REMARK 3 T TENSOR REMARK 3 T11: 0.5863 T22: 0.1344 REMARK 3 T33: 0.1166 T12: 0.1351 REMARK 3 T13: -0.1715 T23: -0.1178 REMARK 3 L TENSOR REMARK 3 L11: 0.4723 L22: 0.0174 REMARK 3 L33: 0.0025 L12: -0.0701 REMARK 3 L13: -0.0328 L23: 0.0064 REMARK 3 S TENSOR REMARK 3 S11: 0.1432 S12: 0.2629 S13: 0.1601 REMARK 3 S21: 0.1752 S22: -0.2789 S23: -0.0173 REMARK 3 S31: -0.1501 S32: -0.1046 S33: -0.1834 REMARK 3 TLS GROUP : 164 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 44 THROUGH 71 ) REMARK 3 ORIGIN FOR THE GROUP (A): -31.3441 -15.8862 -48.1638 REMARK 3 T TENSOR REMARK 3 T11: 0.3236 T22: 0.1962 REMARK 3 T33: 0.4234 T12: 0.1246 REMARK 3 T13: -0.0388 T23: -0.0527 REMARK 3 L TENSOR REMARK 3 L11: 0.1754 L22: 0.1364 REMARK 3 L33: 0.1424 L12: 0.1462 REMARK 3 L13: -0.0978 L23: -0.0746 REMARK 3 S TENSOR REMARK 3 S11: -0.1032 S12: -0.1448 S13: -0.0082 REMARK 3 S21: -0.1241 S22: -0.0403 S23: -0.0031 REMARK 3 S31: 0.0364 S32: 0.0931 S33: -0.1867 REMARK 3 TLS GROUP : 165 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 72 THROUGH 87 ) REMARK 3 ORIGIN FOR THE GROUP (A): -35.9242 -7.3916 -43.7741 REMARK 3 T TENSOR REMARK 3 T11: 0.4821 T22: 0.4311 REMARK 3 T33: 0.3499 T12: 0.4647 REMARK 3 T13: -0.0104 T23: -0.1830 REMARK 3 L TENSOR REMARK 3 L11: 0.0277 L22: -0.0012 REMARK 3 L33: -0.0002 L12: -0.0097 REMARK 3 L13: 0.0008 L23: -0.0020 REMARK 3 S TENSOR REMARK 3 S11: -0.0613 S12: 0.0175 S13: -0.1228 REMARK 3 S21: 0.0289 S22: 0.0058 S23: 0.0435 REMARK 3 S31: 0.0306 S32: -0.0184 S33: -0.0554 REMARK 3 TLS GROUP : 166 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 88 THROUGH 99 ) REMARK 3 ORIGIN FOR THE GROUP (A): -42.9127 -14.1741 -51.6955 REMARK 3 T TENSOR REMARK 3 T11: 0.5315 T22: 0.5436 REMARK 3 T33: 0.5553 T12: 0.0163 REMARK 3 T13: -0.2570 T23: -0.0641 REMARK 3 L TENSOR REMARK 3 L11: 0.0198 L22: 0.0094 REMARK 3 L33: 0.0046 L12: -0.0155 REMARK 3 L13: -0.0095 L23: 0.0041 REMARK 3 S TENSOR REMARK 3 S11: -0.2043 S12: 0.0685 S13: -0.0438 REMARK 3 S21: 0.0852 S22: 0.0439 S23: 0.1063 REMARK 3 S31: 0.0501 S32: 0.0756 S33: -0.0041 REMARK 3 TLS GROUP : 167 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 100 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -39.7164 -24.3045 -40.8567 REMARK 3 T TENSOR REMARK 3 T11: 0.5640 T22: 0.3583 REMARK 3 T33: 0.7908 T12: 0.0481 REMARK 3 T13: -0.0649 T23: -0.0458 REMARK 3 L TENSOR REMARK 3 L11: -0.0013 L22: 0.0114 REMARK 3 L33: 0.0082 L12: -0.0036 REMARK 3 L13: 0.0014 L23: -0.0121 REMARK 3 S TENSOR REMARK 3 S11: 0.1161 S12: -0.0984 S13: -0.0598 REMARK 3 S21: 0.0560 S22: -0.1916 S23: -0.0485 REMARK 3 S31: 0.0215 S32: -0.0564 S33: -0.0001 REMARK 3 TLS GROUP : 168 REMARK 3 SELECTION: CHAIN 'W' AND (RESID 114 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -70.6967 -7.7711 -61.6039 REMARK 3 T TENSOR REMARK 3 T11: 0.5616 T22: 0.3286 REMARK 3 T33: 1.1271 T12: 0.1277 REMARK 3 T13: -0.3508 T23: -0.1546 REMARK 3 L TENSOR REMARK 3 L11: 0.1855 L22: 0.1287 REMARK 3 L33: 0.3496 L12: 0.1855 REMARK 3 L13: -0.0043 L23: 0.1081 REMARK 3 S TENSOR REMARK 3 S11: -0.1161 S12: -0.0335 S13: -0.2297 REMARK 3 S21: 0.0103 S22: -0.1604 S23: 0.7920 REMARK 3 S31: 0.2667 S32: -0.1905 S33: -0.1280 REMARK 3 TLS GROUP : 169 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 1 THROUGH 13 ) REMARK 3 ORIGIN FOR THE GROUP (A): -46.2343 -32.7569 -60.4410 REMARK 3 T TENSOR REMARK 3 T11: 0.7952 T22: 0.4771 REMARK 3 T33: 0.2525 T12: -0.0140 REMARK 3 T13: -0.3504 T23: -0.0272 REMARK 3 L TENSOR REMARK 3 L11: 0.0783 L22: 0.1210 REMARK 3 L33: 0.1382 L12: 0.0260 REMARK 3 L13: 0.0273 L23: 0.1339 REMARK 3 S TENSOR REMARK 3 S11: 0.0575 S12: -0.0010 S13: -0.0584 REMARK 3 S21: -0.0660 S22: 0.1773 S23: 0.0681 REMARK 3 S31: 0.0005 S32: 0.0372 S33: 0.1519 REMARK 3 TLS GROUP : 170 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 14 THROUGH 25 ) REMARK 3 ORIGIN FOR THE GROUP (A): -51.7778 -40.2445 -55.3801 REMARK 3 T TENSOR REMARK 3 T11: 0.3592 T22: 0.3713 REMARK 3 T33: 0.8540 T12: -0.0501 REMARK 3 T13: -0.4804 T23: -0.0080 REMARK 3 L TENSOR REMARK 3 L11: 0.0174 L22: 0.0163 REMARK 3 L33: 0.0265 L12: 0.0042 REMARK 3 L13: 0.0233 L23: 0.0092 REMARK 3 S TENSOR REMARK 3 S11: 0.0113 S12: 0.0533 S13: -0.0031 REMARK 3 S21: -0.0172 S22: -0.1266 S23: 0.0356 REMARK 3 S31: -0.0395 S32: 0.0823 S33: -0.0637 REMARK 3 TLS GROUP : 171 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 26 THROUGH 75 ) REMARK 3 ORIGIN FOR THE GROUP (A): -44.7146 -34.9301 -47.3839 REMARK 3 T TENSOR REMARK 3 T11: -0.0721 T22: -0.4460 REMARK 3 T33: 0.4782 T12: 0.5004 REMARK 3 T13: -0.2493 T23: 0.1418 REMARK 3 L TENSOR REMARK 3 L11: 0.0582 L22: 0.0246 REMARK 3 L33: 0.1336 L12: 0.0231 REMARK 3 L13: 0.0953 L23: 0.0783 REMARK 3 S TENSOR REMARK 3 S11: -0.1975 S12: -0.1107 S13: -0.0454 REMARK 3 S21: 0.0034 S22: -0.0774 S23: 0.0714 REMARK 3 S31: -0.0455 S32: -0.0174 S33: -0.3034 REMARK 3 TLS GROUP : 172 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 76 THROUGH 139 ) REMARK 3 ORIGIN FOR THE GROUP (A): -60.0657 -23.5506 -61.0289 REMARK 3 T TENSOR REMARK 3 T11: 0.6699 T22: 0.2570 REMARK 3 T33: 0.4156 T12: 0.0640 REMARK 3 T13: -0.5099 T23: -0.2458 REMARK 3 L TENSOR REMARK 3 L11: 0.1296 L22: 0.0673 REMARK 3 L33: 0.2836 L12: -0.0721 REMARK 3 L13: -0.2005 L23: 0.1125 REMARK 3 S TENSOR REMARK 3 S11: 0.0993 S12: 0.0181 S13: -0.1432 REMARK 3 S21: -0.5217 S22: -0.0807 S23: 0.2077 REMARK 3 S31: -0.3461 S32: 0.0661 S33: 0.0110 REMARK 3 TLS GROUP : 173 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 140 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): -65.8366 -21.4373 -72.1061 REMARK 3 T TENSOR REMARK 3 T11: 0.9425 T22: 0.5474 REMARK 3 T33: 0.7068 T12: 0.0576 REMARK 3 T13: -0.3988 T23: -0.1772 REMARK 3 L TENSOR REMARK 3 L11: 0.0280 L22: 0.0691 REMARK 3 L33: 0.1968 L12: -0.0330 REMARK 3 L13: 0.0876 L23: -0.0852 REMARK 3 S TENSOR REMARK 3 S11: -0.0912 S12: 0.4019 S13: -0.0358 REMARK 3 S21: -0.1946 S22: -0.2299 S23: -0.0998 REMARK 3 S31: 0.0470 S32: -0.0775 S33: -0.0074 REMARK 3 TLS GROUP : 174 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 173 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): -68.0313 -9.2609 -77.7467 REMARK 3 T TENSOR REMARK 3 T11: 1.1117 T22: 0.6603 REMARK 3 T33: 1.0025 T12: -0.2393 REMARK 3 T13: -0.5283 T23: -0.0300 REMARK 3 L TENSOR REMARK 3 L11: 0.2539 L22: 0.1145 REMARK 3 L33: 0.0570 L12: -0.1286 REMARK 3 L13: -0.0623 L23: -0.0154 REMARK 3 S TENSOR REMARK 3 S11: -0.0039 S12: 0.2410 S13: 0.1632 REMARK 3 S21: 0.0097 S22: 0.0137 S23: -0.0023 REMARK 3 S31: 0.0680 S32: -0.0026 S33: 0.0511 REMARK 3 TLS GROUP : 175 REMARK 3 SELECTION: CHAIN 'X' AND (RESID 189 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -75.1908 -19.0982 -80.3760 REMARK 3 T TENSOR REMARK 3 T11: 1.3501 T22: 0.7879 REMARK 3 T33: 0.9310 T12: -0.1099 REMARK 3 T13: -0.9968 T23: -0.1562 REMARK 3 L TENSOR REMARK 3 L11: 0.0459 L22: 0.0303 REMARK 3 L33: 0.0545 L12: 0.0221 REMARK 3 L13: 0.0134 L23: 0.0363 REMARK 3 S TENSOR REMARK 3 S11: 0.0092 S12: 0.1428 S13: 0.0624 REMARK 3 S21: 0.0269 S22: -0.0109 S23: 0.0132 REMARK 3 S31: 0.1420 S32: -0.1496 S33: -0.0316 REMARK 3 TLS GROUP : 176 REMARK 3 SELECTION: CHAIN 'Z' AND (RESID 1 THROUGH 87 ) REMARK 3 ORIGIN FOR THE GROUP (A): 8.8685 -10.6765 -63.0752 REMARK 3 T TENSOR REMARK 3 T11: 0.2385 T22: 0.2550 REMARK 3 T33: 0.2341 T12: 0.0660 REMARK 3 T13: 0.0837 T23: 0.1629 REMARK 3 L TENSOR REMARK 3 L11: 0.1024 L22: 0.0758 REMARK 3 L33: 0.0279 L12: 0.0172 REMARK 3 L13: -0.0519 L23: -0.0418 REMARK 3 S TENSOR REMARK 3 S11: -0.1203 S12: 0.0890 S13: 0.1480 REMARK 3 S21: -0.1352 S22: -0.0935 S23: -0.3198 REMARK 3 S31: 0.2891 S32: 0.1720 S33: -0.1898 REMARK 3 TLS GROUP : 177 REMARK 3 SELECTION: CHAIN 'Z' AND (RESID 88 THROUGH 126 ) REMARK 3 ORIGIN FOR THE GROUP (A): 3.4059 -6.2417 -67.2308 REMARK 3 T TENSOR REMARK 3 T11: 0.9369 T22: 0.4291 REMARK 3 T33: 0.1964 T12: -0.0812 REMARK 3 T13: 0.2352 T23: 0.0873 REMARK 3 L TENSOR REMARK 3 L11: 0.0975 L22: 0.0468 REMARK 3 L33: 0.0021 L12: -0.0682 REMARK 3 L13: 0.0162 L23: -0.0056 REMARK 3 S TENSOR REMARK 3 S11: 0.0765 S12: -0.0023 S13: 0.1396 REMARK 3 S21: 0.2592 S22: -0.0263 S23: -0.0528 REMARK 3 S31: 0.0152 S32: -0.0170 S33: 0.0743 REMARK 3 TLS GROUP : 178 REMARK 3 SELECTION: CHAIN 'Z' AND (RESID 127 THROUGH 169 ) REMARK 3 ORIGIN FOR THE GROUP (A): -8.5135 16.0947 -88.2546 REMARK 3 T TENSOR REMARK 3 T11: 1.0623 T22: 0.9653 REMARK 3 T33: 1.3839 T12: -0.1037 REMARK 3 T13: 0.0025 T23: 0.1690 REMARK 3 L TENSOR REMARK 3 L11: 0.0188 L22: 0.0281 REMARK 3 L33: 0.0121 L12: -0.0260 REMARK 3 L13: -0.0129 L23: 0.0081 REMARK 3 S TENSOR REMARK 3 S11: -0.1411 S12: -0.0550 S13: 0.1304 REMARK 3 S21: 0.0175 S22: -0.1000 S23: 0.0767 REMARK 3 S31: -0.1657 S32: -0.0812 S33: 0.0000 REMARK 3 TLS GROUP : 179 REMARK 3 SELECTION: CHAIN 'Z' AND (RESID 170 THROUGH 218 ) REMARK 3 ORIGIN FOR THE GROUP (A): -5.6119 15.8041 -87.3717 REMARK 3 T TENSOR REMARK 3 T11: 1.2773 T22: 0.7926 REMARK 3 T33: 1.2830 T12: 0.2456 REMARK 3 T13: 0.1677 T23: 0.3353 REMARK 3 L TENSOR REMARK 3 L11: 0.0017 L22: 0.0133 REMARK 3 L33: 0.0795 L12: -0.0008 REMARK 3 L13: -0.0199 L23: 0.0358 REMARK 3 S TENSOR REMARK 3 S11: 0.0936 S12: -0.0268 S13: 0.2137 REMARK 3 S21: -0.1286 S22: 0.0054 S23: -0.0009 REMARK 3 S31: -0.1590 S32: 0.5415 S33: 0.0090 REMARK 3 TLS GROUP : 180 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 1 THROUGH 17 ) REMARK 3 ORIGIN FOR THE GROUP (A): -18.6407 -10.9371 -69.7598 REMARK 3 T TENSOR REMARK 3 T11: 0.7782 T22: 0.4255 REMARK 3 T33: 0.3638 T12: 0.0848 REMARK 3 T13: 0.0224 T23: -0.0812 REMARK 3 L TENSOR REMARK 3 L11: 0.1409 L22: 0.2819 REMARK 3 L33: 0.0531 L12: -0.0563 REMARK 3 L13: -0.0580 L23: -0.0659 REMARK 3 S TENSOR REMARK 3 S11: -0.1628 S12: -0.2636 S13: -0.1258 REMARK 3 S21: 0.0965 S22: -0.4483 S23: 0.0211 REMARK 3 S31: 0.1562 S32: -0.1088 S33: -0.0324 REMARK 3 TLS GROUP : 181 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 18 THROUGH 38 ) REMARK 3 ORIGIN FOR THE GROUP (A): -15.4640 -15.9314 -62.6720 REMARK 3 T TENSOR REMARK 3 T11: 0.5095 T22: 0.1489 REMARK 3 T33: 0.4389 T12: 0.0426 REMARK 3 T13: -0.1772 T23: 0.1842 REMARK 3 L TENSOR REMARK 3 L11: 0.0587 L22: 0.0837 REMARK 3 L33: 0.0863 L12: -0.0610 REMARK 3 L13: 0.0496 L23: -0.0486 REMARK 3 S TENSOR REMARK 3 S11: 0.0774 S12: 0.0843 S13: -0.1322 REMARK 3 S21: -0.0918 S22: -0.1418 S23: 0.0426 REMARK 3 S31: -0.1197 S32: 0.1033 S33: -0.0809 REMARK 3 TLS GROUP : 182 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 39 THROUGH 61 ) REMARK 3 ORIGIN FOR THE GROUP (A): -12.2150 -6.2757 -55.7260 REMARK 3 T TENSOR REMARK 3 T11: 0.2983 T22: 0.3555 REMARK 3 T33: 0.3911 T12: 0.0665 REMARK 3 T13: -0.0164 T23: 0.0955 REMARK 3 L TENSOR REMARK 3 L11: 0.0212 L22: 0.0505 REMARK 3 L33: 0.0773 L12: 0.0142 REMARK 3 L13: -0.0282 L23: -0.0270 REMARK 3 S TENSOR REMARK 3 S11: -0.2747 S12: -0.0503 S13: 0.1246 REMARK 3 S21: 0.0809 S22: -0.0766 S23: -0.0749 REMARK 3 S31: -0.0285 S32: 0.0695 S33: -0.0552 REMARK 3 TLS GROUP : 183 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 62 THROUGH 90 ) REMARK 3 ORIGIN FOR THE GROUP (A): -18.2005 -9.3169 -61.3772 REMARK 3 T TENSOR REMARK 3 T11: 0.5757 T22: 0.3117 REMARK 3 T33: 0.2843 T12: -0.0171 REMARK 3 T13: -0.0980 T23: -0.0111 REMARK 3 L TENSOR REMARK 3 L11: 1.0358 L22: 0.5196 REMARK 3 L33: 0.2434 L12: 0.3246 REMARK 3 L13: -0.5054 L23: -0.1548 REMARK 3 S TENSOR REMARK 3 S11: -0.2974 S12: -0.1701 S13: -0.1464 REMARK 3 S21: -0.1645 S22: -0.1718 S23: -0.1117 REMARK 3 S31: -0.2316 S32: 0.1131 S33: -0.1415 REMARK 3 TLS GROUP : 184 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 91 THROUGH 102 ) REMARK 3 ORIGIN FOR THE GROUP (A): -6.1630 -18.6174 -64.1901 REMARK 3 T TENSOR REMARK 3 T11: 0.7862 T22: 0.1303 REMARK 3 T33: 0.4400 T12: 0.1175 REMARK 3 T13: -0.0593 T23: 0.0086 REMARK 3 L TENSOR REMARK 3 L11: 0.0479 L22: 0.3632 REMARK 3 L33: 0.1378 L12: -0.1281 REMARK 3 L13: -0.0511 L23: 0.0570 REMARK 3 S TENSOR REMARK 3 S11: -0.0287 S12: -0.0379 S13: -0.1896 REMARK 3 S21: 0.0732 S22: -0.1202 S23: -0.0865 REMARK 3 S31: 0.0023 S32: -0.0415 S33: -0.0368 REMARK 3 TLS GROUP : 185 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 103 THROUGH 113 ) REMARK 3 ORIGIN FOR THE GROUP (A): -25.1754 3.0831 -75.7129 REMARK 3 T TENSOR REMARK 3 T11: 0.5356 T22: 0.5159 REMARK 3 T33: 0.3824 T12: 0.3615 REMARK 3 T13: 0.0681 T23: -0.3564 REMARK 3 L TENSOR REMARK 3 L11: 0.0821 L22: 0.0389 REMARK 3 L33: 0.0742 L12: 0.0121 REMARK 3 L13: -0.0381 L23: 0.0406 REMARK 3 S TENSOR REMARK 3 S11: 0.0552 S12: 0.1327 S13: 0.0364 REMARK 3 S21: 0.0043 S22: 0.0172 S23: 0.0016 REMARK 3 S31: 0.0461 S32: 0.0120 S33: 0.0338 REMARK 3 TLS GROUP : 186 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 114 THROUGH 139 ) REMARK 3 ORIGIN FOR THE GROUP (A): -11.3068 11.3652 -95.8947 REMARK 3 T TENSOR REMARK 3 T11: 0.4567 T22: 1.3746 REMARK 3 T33: 0.6264 T12: -0.2501 REMARK 3 T13: -0.1668 T23: 0.4048 REMARK 3 L TENSOR REMARK 3 L11: 0.0489 L22: 0.2426 REMARK 3 L33: 0.0807 L12: -0.0956 REMARK 3 L13: -0.0615 L23: 0.1386 REMARK 3 S TENSOR REMARK 3 S11: -0.0139 S12: 0.1199 S13: 0.0838 REMARK 3 S21: -0.0405 S22: -0.2035 S23: -0.0053 REMARK 3 S31: 0.0634 S32: 0.0920 S33: -0.0555 REMARK 3 TLS GROUP : 187 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 140 THROUGH 172 ) REMARK 3 ORIGIN FOR THE GROUP (A): -17.7240 1.7876 -90.2893 REMARK 3 T TENSOR REMARK 3 T11: 1.0347 T22: 0.9319 REMARK 3 T33: 0.4542 T12: 0.0890 REMARK 3 T13: -0.1187 T23: -0.1602 REMARK 3 L TENSOR REMARK 3 L11: 0.0322 L22: 0.0369 REMARK 3 L33: 0.0215 L12: -0.0084 REMARK 3 L13: -0.0007 L23: -0.0328 REMARK 3 S TENSOR REMARK 3 S11: -0.1218 S12: 0.3224 S13: -0.0124 REMARK 3 S21: 0.2337 S22: -0.0427 S23: -0.0447 REMARK 3 S31: -0.0135 S32: 0.1310 S33: 0.0000 REMARK 3 TLS GROUP : 188 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 173 THROUGH 188 ) REMARK 3 ORIGIN FOR THE GROUP (A): -9.3226 5.2791-100.3416 REMARK 3 T TENSOR REMARK 3 T11: 0.4879 T22: 0.7912 REMARK 3 T33: 0.7867 T12: 0.2864 REMARK 3 T13: -0.1200 T23: 0.1206 REMARK 3 L TENSOR REMARK 3 L11: 0.0077 L22: 0.0138 REMARK 3 L33: 0.0018 L12: -0.0004 REMARK 3 L13: 0.0030 L23: -0.0029 REMARK 3 S TENSOR REMARK 3 S11: -0.0797 S12: 0.1385 S13: -0.0604 REMARK 3 S21: 0.2639 S22: 0.0847 S23: -0.0651 REMARK 3 S31: 0.0275 S32: 0.0616 S33: 0.0000 REMARK 3 TLS GROUP : 189 REMARK 3 SELECTION: CHAIN 'A' AND (RESID 189 THROUGH 214 ) REMARK 3 ORIGIN FOR THE GROUP (A): -21.5368 7.6057-100.9169 REMARK 3 T TENSOR REMARK 3 T11: 0.8366 T22: 1.1798 REMARK 3 T33: 0.5665 T12: -0.0698 REMARK 3 T13: 0.0141 T23: 0.2941 REMARK 3 L TENSOR REMARK 3 L11: 0.0234 L22: 0.0185 REMARK 3 L33: -0.0002 L12: 0.0166 REMARK 3 L13: -0.0056 L23: -0.0009 REMARK 3 S TENSOR REMARK 3 S11: -0.0072 S12: 0.1533 S13: 0.0673 REMARK 3 S21: -0.1896 S22: -0.1576 S23: -0.0592 REMARK 3 S31: -0.0047 S32: -0.0418 S33: -0.0264 REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : 3 REMARK 3 NCS GROUP : 1 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN D REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN G REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 3 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN J REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 4 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN M REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 5 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN P REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 6 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN S REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 7 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN V REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 8 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN Y REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 9 REMARK 3 REFERENCE SELECTION: CHAIN A REMARK 3 SELECTION : CHAIN B REMARK 3 ATOM PAIRS NUMBER : 20081 REMARK 3 RMSD : NULL REMARK 3 NCS GROUP : 2 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN E REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN H REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 3 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN K REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 4 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN N REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 5 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN Q REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 6 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN T REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 7 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN W REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 8 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN Z REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 9 REMARK 3 REFERENCE SELECTION: CHAIN B REMARK 3 SELECTION : CHAIN G REMARK 3 ATOM PAIRS NUMBER : 10036 REMARK 3 RMSD : NULL REMARK 3 NCS GROUP : 3 REMARK 3 NCS OPERATOR : 1 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN F REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 2 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN I REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 3 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN L REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 4 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN O REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 5 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN R REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 6 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN U REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 7 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN X REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 8 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN A REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 NCS OPERATOR : 9 REMARK 3 REFERENCE SELECTION: CHAIN C REMARK 3 SELECTION : CHAIN J REMARK 3 ATOM PAIRS NUMBER : 10285 REMARK 3 RMSD : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 7EW5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ. REMARK 100 THE DEPOSITION ID IS D_1300022089. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 20-OCT-13 REMARK 200 TEMPERATURE (KELVIN) : 123.15 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SSRF REMARK 200 BEAMLINE : BL17U1 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.9795 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS 2M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 REMARK 200 DATA SCALING SOFTWARE : HKL-2000 REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 133760 REMARK 200 RESOLUTION RANGE HIGH (A) : 3.600 REMARK 200 RESOLUTION RANGE LOW (A) : 50.000 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.9 REMARK 200 DATA REDUNDANCY : 3.800 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : 0.30600 REMARK 200 FOR THE DATA SET : 5.1000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.61 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.67 REMARK 200 COMPLETENESS FOR SHELL (%) : 99.9 REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : 0.95500 REMARK 200 FOR SHELL : NULL REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: 1PLG, 5Y9E REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 57.57 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.90 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M HEPES PH 7.0, 8.2% PEG 20000, REMARK 280 VAPOR DIFFUSION, TEMPERATURE 293.15K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 104.15450 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 30-MERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D, G, J, M, P, S, V, Y, b, REMARK 350 AND CHAINS: B, C, E, F, H, I, K, L, N, REMARK 350 AND CHAINS: O, g, j, Q, R, T, U, W, X, Z, REMARK 350 AND CHAINS: a REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -2 REMARK 465 ASP A -1 REMARK 465 SER A 0 REMARK 465 THR A 1 REMARK 465 VAL A 2 REMARK 465 TYR A 3 REMARK 465 VAL A 4 REMARK 465 PRO A 5 REMARK 465 PRO A 6 REMARK 465 PRO A 7 REMARK 465 ASN A 8 REMARK 465 PRO A 9 REMARK 465 VAL A 10 REMARK 465 SER A 11 REMARK 465 GLY A 393 REMARK 465 LEU A 394 REMARK 465 SER A 395 REMARK 465 PRO A 396 REMARK 465 PRO A 397 REMARK 465 PRO A 398 REMARK 465 ASN A 399 REMARK 465 GLY A 400 REMARK 465 THR A 401 REMARK 465 LEU A 402 REMARK 465 GLU A 403 REMARK 465 ASP A 404 REMARK 465 THR A 405 REMARK 465 TYR A 406 REMARK 465 ARG A 407 REMARK 465 TYR A 408 REMARK 465 VAL A 409 REMARK 465 GLN A 410 REMARK 465 SER A 411 REMARK 465 GLN A 412 REMARK 465 ALA A 413 REMARK 465 ILE A 414 REMARK 465 THR A 415 REMARK 465 CYS A 416 REMARK 465 GLN A 417 REMARK 465 LYS A 418 REMARK 465 PRO A 419 REMARK 465 THR A 420 REMARK 465 PRO A 421 REMARK 465 GLU A 422 REMARK 465 LYS A 423 REMARK 465 GLN A 424 REMARK 465 LYS A 425 REMARK 465 GLY A 461 REMARK 465 TYR A 462 REMARK 465 ARG A 463 REMARK 465 GLY A 464 REMARK 465 ARG A 465 REMARK 465 SER A 466 REMARK 465 SER A 467 REMARK 465 ILE A 468 REMARK 465 ARG A 469 REMARK 465 THR A 470 REMARK 465 GLY A 471 REMARK 465 VAL A 472 REMARK 465 LYS A 473 REMARK 465 ARG A 474 REMARK 465 PRO A 475 REMARK 465 ALA A 476 REMARK 465 VAL A 477 REMARK 465 SER A 478 REMARK 465 LYS A 479 REMARK 465 ALA A 480 REMARK 465 SER A 481 REMARK 465 ALA A 482 REMARK 465 ALA A 483 REMARK 465 PRO A 484 REMARK 465 LYS A 485 REMARK 465 ARG A 486 REMARK 465 LYS A 487 REMARK 465 ARG A 488 REMARK 465 ALA A 489 REMARK 465 LYS A 490 REMARK 465 THR A 491 REMARK 465 LYS A 492 REMARK 465 ARG A 493 REMARK 465 MET D -2 REMARK 465 ASP D -1 REMARK 465 SER D 0 REMARK 465 THR D 1 REMARK 465 VAL D 2 REMARK 465 TYR D 3 REMARK 465 VAL D 4 REMARK 465 PRO D 5 REMARK 465 PRO D 6 REMARK 465 PRO D 7 REMARK 465 ASN D 8 REMARK 465 PRO D 9 REMARK 465 VAL D 10 REMARK 465 SER D 11 REMARK 465 GLY D 393 REMARK 465 LEU D 394 REMARK 465 SER D 395 REMARK 465 PRO D 396 REMARK 465 PRO D 397 REMARK 465 PRO D 398 REMARK 465 ASN D 399 REMARK 465 GLY D 400 REMARK 465 THR D 401 REMARK 465 LEU D 402 REMARK 465 GLU D 403 REMARK 465 ASP D 404 REMARK 465 THR D 405 REMARK 465 TYR D 406 REMARK 465 ARG D 407 REMARK 465 TYR D 408 REMARK 465 VAL D 409 REMARK 465 GLN D 410 REMARK 465 SER D 411 REMARK 465 GLN D 412 REMARK 465 ALA D 413 REMARK 465 ILE D 414 REMARK 465 THR D 415 REMARK 465 CYS D 416 REMARK 465 GLN D 417 REMARK 465 LYS D 418 REMARK 465 PRO D 419 REMARK 465 THR D 420 REMARK 465 PRO D 421 REMARK 465 GLU D 422 REMARK 465 LYS D 423 REMARK 465 GLN D 424 REMARK 465 LYS D 425 REMARK 465 GLY D 461 REMARK 465 TYR D 462 REMARK 465 ARG D 463 REMARK 465 GLY D 464 REMARK 465 ARG D 465 REMARK 465 SER D 466 REMARK 465 SER D 467 REMARK 465 ILE D 468 REMARK 465 ARG D 469 REMARK 465 THR D 470 REMARK 465 GLY D 471 REMARK 465 VAL D 472 REMARK 465 LYS D 473 REMARK 465 ARG D 474 REMARK 465 PRO D 475 REMARK 465 ALA D 476 REMARK 465 VAL D 477 REMARK 465 SER D 478 REMARK 465 LYS D 479 REMARK 465 ALA D 480 REMARK 465 SER D 481 REMARK 465 ALA D 482 REMARK 465 ALA D 483 REMARK 465 PRO D 484 REMARK 465 LYS D 485 REMARK 465 ARG D 486 REMARK 465 LYS D 487 REMARK 465 ARG D 488 REMARK 465 ALA D 489 REMARK 465 LYS D 490 REMARK 465 THR D 491 REMARK 465 LYS D 492 REMARK 465 ARG D 493 REMARK 465 MET G -2 REMARK 465 ASP G -1 REMARK 465 SER G 0 REMARK 465 THR G 1 REMARK 465 VAL G 2 REMARK 465 TYR G 3 REMARK 465 VAL G 4 REMARK 465 PRO G 5 REMARK 465 PRO G 6 REMARK 465 PRO G 7 REMARK 465 ASN G 8 REMARK 465 PRO G 9 REMARK 465 VAL G 10 REMARK 465 SER G 11 REMARK 465 GLY G 393 REMARK 465 LEU G 394 REMARK 465 SER G 395 REMARK 465 PRO G 396 REMARK 465 PRO G 397 REMARK 465 PRO G 398 REMARK 465 ASN G 399 REMARK 465 GLY G 400 REMARK 465 THR G 401 REMARK 465 LEU G 402 REMARK 465 GLU G 403 REMARK 465 ASP G 404 REMARK 465 THR G 405 REMARK 465 TYR G 406 REMARK 465 ARG G 407 REMARK 465 TYR G 408 REMARK 465 VAL G 409 REMARK 465 GLN G 410 REMARK 465 SER G 411 REMARK 465 GLN G 412 REMARK 465 ALA G 413 REMARK 465 ILE G 414 REMARK 465 THR G 415 REMARK 465 CYS G 416 REMARK 465 GLN G 417 REMARK 465 LYS G 418 REMARK 465 PRO G 419 REMARK 465 THR G 420 REMARK 465 PRO G 421 REMARK 465 GLU G 422 REMARK 465 LYS G 423 REMARK 465 GLN G 424 REMARK 465 LYS G 425 REMARK 465 GLY G 461 REMARK 465 TYR G 462 REMARK 465 ARG G 463 REMARK 465 GLY G 464 REMARK 465 ARG G 465 REMARK 465 SER G 466 REMARK 465 SER G 467 REMARK 465 ILE G 468 REMARK 465 ARG G 469 REMARK 465 THR G 470 REMARK 465 GLY G 471 REMARK 465 VAL G 472 REMARK 465 LYS G 473 REMARK 465 ARG G 474 REMARK 465 PRO G 475 REMARK 465 ALA G 476 REMARK 465 VAL G 477 REMARK 465 SER G 478 REMARK 465 LYS G 479 REMARK 465 ALA G 480 REMARK 465 SER G 481 REMARK 465 ALA G 482 REMARK 465 ALA G 483 REMARK 465 PRO G 484 REMARK 465 LYS G 485 REMARK 465 ARG G 486 REMARK 465 LYS G 487 REMARK 465 ARG G 488 REMARK 465 ALA G 489 REMARK 465 LYS G 490 REMARK 465 THR G 491 REMARK 465 LYS G 492 REMARK 465 ARG G 493 REMARK 465 MET J -2 REMARK 465 ASP J -1 REMARK 465 SER J 0 REMARK 465 THR J 1 REMARK 465 VAL J 2 REMARK 465 TYR J 3 REMARK 465 VAL J 4 REMARK 465 PRO J 5 REMARK 465 PRO J 6 REMARK 465 PRO J 7 REMARK 465 ASN J 8 REMARK 465 PRO J 9 REMARK 465 VAL J 10 REMARK 465 SER J 11 REMARK 465 GLY J 393 REMARK 465 LEU J 394 REMARK 465 SER J 395 REMARK 465 PRO J 396 REMARK 465 PRO J 397 REMARK 465 PRO J 398 REMARK 465 ASN J 399 REMARK 465 GLY J 400 REMARK 465 THR J 401 REMARK 465 LEU J 402 REMARK 465 GLU J 403 REMARK 465 ASP J 404 REMARK 465 THR J 405 REMARK 465 TYR J 406 REMARK 465 ARG J 407 REMARK 465 TYR J 408 REMARK 465 VAL J 409 REMARK 465 GLN J 410 REMARK 465 SER J 411 REMARK 465 GLN J 412 REMARK 465 ALA J 413 REMARK 465 ILE J 414 REMARK 465 THR J 415 REMARK 465 CYS J 416 REMARK 465 GLN J 417 REMARK 465 LYS J 418 REMARK 465 PRO J 419 REMARK 465 THR J 420 REMARK 465 PRO J 421 REMARK 465 GLU J 422 REMARK 465 LYS J 423 REMARK 465 GLN J 424 REMARK 465 LYS J 425 REMARK 465 GLY J 461 REMARK 465 TYR J 462 REMARK 465 ARG J 463 REMARK 465 GLY J 464 REMARK 465 ARG J 465 REMARK 465 SER J 466 REMARK 465 SER J 467 REMARK 465 ILE J 468 REMARK 465 ARG J 469 REMARK 465 THR J 470 REMARK 465 GLY J 471 REMARK 465 VAL J 472 REMARK 465 LYS J 473 REMARK 465 ARG J 474 REMARK 465 PRO J 475 REMARK 465 ALA J 476 REMARK 465 VAL J 477 REMARK 465 SER J 478 REMARK 465 LYS J 479 REMARK 465 ALA J 480 REMARK 465 SER J 481 REMARK 465 ALA J 482 REMARK 465 ALA J 483 REMARK 465 PRO J 484 REMARK 465 LYS J 485 REMARK 465 ARG J 486 REMARK 465 LYS J 487 REMARK 465 ARG J 488 REMARK 465 ALA J 489 REMARK 465 LYS J 490 REMARK 465 THR J 491 REMARK 465 LYS J 492 REMARK 465 ARG J 493 REMARK 465 MET M -2 REMARK 465 ASP M -1 REMARK 465 SER M 0 REMARK 465 THR M 1 REMARK 465 VAL M 2 REMARK 465 TYR M 3 REMARK 465 VAL M 4 REMARK 465 PRO M 5 REMARK 465 PRO M 6 REMARK 465 PRO M 7 REMARK 465 ASN M 8 REMARK 465 PRO M 9 REMARK 465 VAL M 10 REMARK 465 SER M 11 REMARK 465 GLY M 393 REMARK 465 LEU M 394 REMARK 465 SER M 395 REMARK 465 PRO M 396 REMARK 465 PRO M 397 REMARK 465 PRO M 398 REMARK 465 ASN M 399 REMARK 465 GLY M 400 REMARK 465 THR M 401 REMARK 465 LEU M 402 REMARK 465 GLU M 403 REMARK 465 ASP M 404 REMARK 465 THR M 405 REMARK 465 TYR M 406 REMARK 465 ARG M 407 REMARK 465 TYR M 408 REMARK 465 VAL M 409 REMARK 465 GLN M 410 REMARK 465 SER M 411 REMARK 465 GLN M 412 REMARK 465 ALA M 413 REMARK 465 ILE M 414 REMARK 465 THR M 415 REMARK 465 CYS M 416 REMARK 465 GLN M 417 REMARK 465 LYS M 418 REMARK 465 PRO M 419 REMARK 465 THR M 420 REMARK 465 PRO M 421 REMARK 465 GLU M 422 REMARK 465 LYS M 423 REMARK 465 GLN M 424 REMARK 465 LYS M 425 REMARK 465 GLY M 461 REMARK 465 TYR M 462 REMARK 465 ARG M 463 REMARK 465 GLY M 464 REMARK 465 ARG M 465 REMARK 465 SER M 466 REMARK 465 SER M 467 REMARK 465 ILE M 468 REMARK 465 ARG M 469 REMARK 465 THR M 470 REMARK 465 GLY M 471 REMARK 465 VAL M 472 REMARK 465 LYS M 473 REMARK 465 ARG M 474 REMARK 465 PRO M 475 REMARK 465 ALA M 476 REMARK 465 VAL M 477 REMARK 465 SER M 478 REMARK 465 LYS M 479 REMARK 465 ALA M 480 REMARK 465 SER M 481 REMARK 465 ALA M 482 REMARK 465 ALA M 483 REMARK 465 PRO M 484 REMARK 465 LYS M 485 REMARK 465 ARG M 486 REMARK 465 LYS M 487 REMARK 465 ARG M 488 REMARK 465 ALA M 489 REMARK 465 LYS M 490 REMARK 465 THR M 491 REMARK 465 LYS M 492 REMARK 465 ARG M 493 REMARK 465 MET P -2 REMARK 465 ASP P -1 REMARK 465 SER P 0 REMARK 465 THR P 1 REMARK 465 VAL P 2 REMARK 465 TYR P 3 REMARK 465 VAL P 4 REMARK 465 PRO P 5 REMARK 465 PRO P 6 REMARK 465 PRO P 7 REMARK 465 ASN P 8 REMARK 465 PRO P 9 REMARK 465 VAL P 10 REMARK 465 SER P 11 REMARK 465 GLY P 393 REMARK 465 LEU P 394 REMARK 465 SER P 395 REMARK 465 PRO P 396 REMARK 465 PRO P 397 REMARK 465 PRO P 398 REMARK 465 ASN P 399 REMARK 465 GLY P 400 REMARK 465 THR P 401 REMARK 465 LEU P 402 REMARK 465 GLU P 403 REMARK 465 ASP P 404 REMARK 465 THR P 405 REMARK 465 TYR P 406 REMARK 465 ARG P 407 REMARK 465 TYR P 408 REMARK 465 VAL P 409 REMARK 465 GLN P 410 REMARK 465 SER P 411 REMARK 465 GLN P 412 REMARK 465 ALA P 413 REMARK 465 ILE P 414 REMARK 465 THR P 415 REMARK 465 CYS P 416 REMARK 465 GLN P 417 REMARK 465 LYS P 418 REMARK 465 PRO P 419 REMARK 465 THR P 420 REMARK 465 PRO P 421 REMARK 465 GLU P 422 REMARK 465 LYS P 423 REMARK 465 GLN P 424 REMARK 465 LYS P 425 REMARK 465 GLY P 461 REMARK 465 TYR P 462 REMARK 465 ARG P 463 REMARK 465 GLY P 464 REMARK 465 ARG P 465 REMARK 465 SER P 466 REMARK 465 SER P 467 REMARK 465 ILE P 468 REMARK 465 ARG P 469 REMARK 465 THR P 470 REMARK 465 GLY P 471 REMARK 465 VAL P 472 REMARK 465 LYS P 473 REMARK 465 ARG P 474 REMARK 465 PRO P 475 REMARK 465 ALA P 476 REMARK 465 VAL P 477 REMARK 465 SER P 478 REMARK 465 LYS P 479 REMARK 465 ALA P 480 REMARK 465 SER P 481 REMARK 465 ALA P 482 REMARK 465 ALA P 483 REMARK 465 PRO P 484 REMARK 465 LYS P 485 REMARK 465 ARG P 486 REMARK 465 LYS P 487 REMARK 465 ARG P 488 REMARK 465 ALA P 489 REMARK 465 LYS P 490 REMARK 465 THR P 491 REMARK 465 LYS P 492 REMARK 465 ARG P 493 REMARK 465 MET S -2 REMARK 465 ASP S -1 REMARK 465 SER S 0 REMARK 465 THR S 1 REMARK 465 VAL S 2 REMARK 465 TYR S 3 REMARK 465 VAL S 4 REMARK 465 PRO S 5 REMARK 465 PRO S 6 REMARK 465 PRO S 7 REMARK 465 ASN S 8 REMARK 465 PRO S 9 REMARK 465 VAL S 10 REMARK 465 SER S 11 REMARK 465 GLY S 393 REMARK 465 LEU S 394 REMARK 465 SER S 395 REMARK 465 PRO S 396 REMARK 465 PRO S 397 REMARK 465 PRO S 398 REMARK 465 ASN S 399 REMARK 465 GLY S 400 REMARK 465 THR S 401 REMARK 465 LEU S 402 REMARK 465 GLU S 403 REMARK 465 ASP S 404 REMARK 465 THR S 405 REMARK 465 TYR S 406 REMARK 465 ARG S 407 REMARK 465 TYR S 408 REMARK 465 VAL S 409 REMARK 465 GLN S 410 REMARK 465 SER S 411 REMARK 465 GLN S 412 REMARK 465 ALA S 413 REMARK 465 ILE S 414 REMARK 465 THR S 415 REMARK 465 CYS S 416 REMARK 465 GLN S 417 REMARK 465 LYS S 418 REMARK 465 PRO S 419 REMARK 465 THR S 420 REMARK 465 PRO S 421 REMARK 465 GLU S 422 REMARK 465 LYS S 423 REMARK 465 GLN S 424 REMARK 465 LYS S 425 REMARK 465 GLY S 461 REMARK 465 TYR S 462 REMARK 465 ARG S 463 REMARK 465 GLY S 464 REMARK 465 ARG S 465 REMARK 465 SER S 466 REMARK 465 SER S 467 REMARK 465 ILE S 468 REMARK 465 ARG S 469 REMARK 465 THR S 470 REMARK 465 GLY S 471 REMARK 465 VAL S 472 REMARK 465 LYS S 473 REMARK 465 ARG S 474 REMARK 465 PRO S 475 REMARK 465 ALA S 476 REMARK 465 VAL S 477 REMARK 465 SER S 478 REMARK 465 LYS S 479 REMARK 465 ALA S 480 REMARK 465 SER S 481 REMARK 465 ALA S 482 REMARK 465 ALA S 483 REMARK 465 PRO S 484 REMARK 465 LYS S 485 REMARK 465 ARG S 486 REMARK 465 LYS S 487 REMARK 465 ARG S 488 REMARK 465 ALA S 489 REMARK 465 LYS S 490 REMARK 465 THR S 491 REMARK 465 LYS S 492 REMARK 465 ARG S 493 REMARK 465 MET V -2 REMARK 465 ASP V -1 REMARK 465 SER V 0 REMARK 465 THR V 1 REMARK 465 VAL V 2 REMARK 465 TYR V 3 REMARK 465 VAL V 4 REMARK 465 PRO V 5 REMARK 465 PRO V 6 REMARK 465 PRO V 7 REMARK 465 ASN V 8 REMARK 465 PRO V 9 REMARK 465 VAL V 10 REMARK 465 SER V 11 REMARK 465 GLY V 393 REMARK 465 LEU V 394 REMARK 465 SER V 395 REMARK 465 PRO V 396 REMARK 465 PRO V 397 REMARK 465 PRO V 398 REMARK 465 ASN V 399 REMARK 465 GLY V 400 REMARK 465 THR V 401 REMARK 465 LEU V 402 REMARK 465 GLU V 403 REMARK 465 ASP V 404 REMARK 465 THR V 405 REMARK 465 TYR V 406 REMARK 465 ARG V 407 REMARK 465 TYR V 408 REMARK 465 VAL V 409 REMARK 465 GLN V 410 REMARK 465 SER V 411 REMARK 465 GLN V 412 REMARK 465 ALA V 413 REMARK 465 ILE V 414 REMARK 465 THR V 415 REMARK 465 CYS V 416 REMARK 465 GLN V 417 REMARK 465 LYS V 418 REMARK 465 PRO V 419 REMARK 465 THR V 420 REMARK 465 PRO V 421 REMARK 465 GLU V 422 REMARK 465 LYS V 423 REMARK 465 GLN V 424 REMARK 465 LYS V 425 REMARK 465 GLY V 461 REMARK 465 TYR V 462 REMARK 465 ARG V 463 REMARK 465 GLY V 464 REMARK 465 ARG V 465 REMARK 465 SER V 466 REMARK 465 SER V 467 REMARK 465 ILE V 468 REMARK 465 ARG V 469 REMARK 465 THR V 470 REMARK 465 GLY V 471 REMARK 465 VAL V 472 REMARK 465 LYS V 473 REMARK 465 ARG V 474 REMARK 465 PRO V 475 REMARK 465 ALA V 476 REMARK 465 VAL V 477 REMARK 465 SER V 478 REMARK 465 LYS V 479 REMARK 465 ALA V 480 REMARK 465 SER V 481 REMARK 465 ALA V 482 REMARK 465 ALA V 483 REMARK 465 PRO V 484 REMARK 465 LYS V 485 REMARK 465 ARG V 486 REMARK 465 LYS V 487 REMARK 465 ARG V 488 REMARK 465 ALA V 489 REMARK 465 LYS V 490 REMARK 465 THR V 491 REMARK 465 LYS V 492 REMARK 465 ARG V 493 REMARK 465 MET Y -2 REMARK 465 ASP Y -1 REMARK 465 SER Y 0 REMARK 465 THR Y 1 REMARK 465 VAL Y 2 REMARK 465 TYR Y 3 REMARK 465 VAL Y 4 REMARK 465 PRO Y 5 REMARK 465 PRO Y 6 REMARK 465 PRO Y 7 REMARK 465 ASN Y 8 REMARK 465 PRO Y 9 REMARK 465 VAL Y 10 REMARK 465 SER Y 11 REMARK 465 GLY Y 393 REMARK 465 LEU Y 394 REMARK 465 SER Y 395 REMARK 465 PRO Y 396 REMARK 465 PRO Y 397 REMARK 465 PRO Y 398 REMARK 465 ASN Y 399 REMARK 465 GLY Y 400 REMARK 465 THR Y 401 REMARK 465 LEU Y 402 REMARK 465 GLU Y 403 REMARK 465 ASP Y 404 REMARK 465 THR Y 405 REMARK 465 TYR Y 406 REMARK 465 ARG Y 407 REMARK 465 TYR Y 408 REMARK 465 VAL Y 409 REMARK 465 GLN Y 410 REMARK 465 SER Y 411 REMARK 465 GLN Y 412 REMARK 465 ALA Y 413 REMARK 465 ILE Y 414 REMARK 465 THR Y 415 REMARK 465 CYS Y 416 REMARK 465 GLN Y 417 REMARK 465 LYS Y 418 REMARK 465 PRO Y 419 REMARK 465 THR Y 420 REMARK 465 PRO Y 421 REMARK 465 GLU Y 422 REMARK 465 LYS Y 423 REMARK 465 GLN Y 424 REMARK 465 LYS Y 425 REMARK 465 GLY Y 461 REMARK 465 TYR Y 462 REMARK 465 ARG Y 463 REMARK 465 GLY Y 464 REMARK 465 ARG Y 465 REMARK 465 SER Y 466 REMARK 465 SER Y 467 REMARK 465 ILE Y 468 REMARK 465 ARG Y 469 REMARK 465 THR Y 470 REMARK 465 GLY Y 471 REMARK 465 VAL Y 472 REMARK 465 LYS Y 473 REMARK 465 ARG Y 474 REMARK 465 PRO Y 475 REMARK 465 ALA Y 476 REMARK 465 VAL Y 477 REMARK 465 SER Y 478 REMARK 465 LYS Y 479 REMARK 465 ALA Y 480 REMARK 465 SER Y 481 REMARK 465 ALA Y 482 REMARK 465 ALA Y 483 REMARK 465 PRO Y 484 REMARK 465 LYS Y 485 REMARK 465 ARG Y 486 REMARK 465 LYS Y 487 REMARK 465 ARG Y 488 REMARK 465 ALA Y 489 REMARK 465 LYS Y 490 REMARK 465 THR Y 491 REMARK 465 LYS Y 492 REMARK 465 ARG Y 493 REMARK 465 MET b -2 REMARK 465 ASP b -1 REMARK 465 SER b 0 REMARK 465 THR b 1 REMARK 465 VAL b 2 REMARK 465 TYR b 3 REMARK 465 VAL b 4 REMARK 465 PRO b 5 REMARK 465 PRO b 6 REMARK 465 PRO b 7 REMARK 465 ASN b 8 REMARK 465 PRO b 9 REMARK 465 VAL b 10 REMARK 465 SER b 11 REMARK 465 GLY b 393 REMARK 465 LEU b 394 REMARK 465 SER b 395 REMARK 465 PRO b 396 REMARK 465 PRO b 397 REMARK 465 PRO b 398 REMARK 465 ASN b 399 REMARK 465 GLY b 400 REMARK 465 THR b 401 REMARK 465 LEU b 402 REMARK 465 GLU b 403 REMARK 465 ASP b 404 REMARK 465 THR b 405 REMARK 465 TYR b 406 REMARK 465 ARG b 407 REMARK 465 TYR b 408 REMARK 465 VAL b 409 REMARK 465 GLN b 410 REMARK 465 SER b 411 REMARK 465 GLN b 412 REMARK 465 ALA b 413 REMARK 465 ILE b 414 REMARK 465 THR b 415 REMARK 465 CYS b 416 REMARK 465 GLN b 417 REMARK 465 LYS b 418 REMARK 465 PRO b 419 REMARK 465 THR b 420 REMARK 465 PRO b 421 REMARK 465 GLU b 422 REMARK 465 LYS b 423 REMARK 465 GLN b 424 REMARK 465 LYS b 425 REMARK 465 GLY b 461 REMARK 465 TYR b 462 REMARK 465 ARG b 463 REMARK 465 GLY b 464 REMARK 465 ARG b 465 REMARK 465 SER b 466 REMARK 465 SER b 467 REMARK 465 ILE b 468 REMARK 465 ARG b 469 REMARK 465 THR b 470 REMARK 465 GLY b 471 REMARK 465 VAL b 472 REMARK 465 LYS b 473 REMARK 465 ARG b 474 REMARK 465 PRO b 475 REMARK 465 ALA b 476 REMARK 465 VAL b 477 REMARK 465 SER b 478 REMARK 465 LYS b 479 REMARK 465 ALA b 480 REMARK 465 SER b 481 REMARK 465 ALA b 482 REMARK 465 ALA b 483 REMARK 465 PRO b 484 REMARK 465 LYS b 485 REMARK 465 ARG b 486 REMARK 465 LYS b 487 REMARK 465 ARG b 488 REMARK 465 ALA b 489 REMARK 465 LYS b 490 REMARK 465 THR b 491 REMARK 465 LYS b 492 REMARK 465 ARG b 493 REMARK 465 PRO B 219 REMARK 465 ARG B 220 REMARK 465 ASP B 221 REMARK 465 PRO E 219 REMARK 465 ARG E 220 REMARK 465 ASP E 221 REMARK 465 PRO H 219 REMARK 465 ARG H 220 REMARK 465 ASP H 221 REMARK 465 PRO K 219 REMARK 465 ARG K 220 REMARK 465 ASP K 221 REMARK 465 PRO N 219 REMARK 465 ARG N 220 REMARK 465 ASP N 221 REMARK 465 PRO g 219 REMARK 465 ARG g 220 REMARK 465 ASP g 221 REMARK 465 PRO Q 219 REMARK 465 ARG Q 220 REMARK 465 ASP Q 221 REMARK 465 PRO T 219 REMARK 465 ARG T 220 REMARK 465 ASP T 221 REMARK 465 PRO W 219 REMARK 465 ARG W 220 REMARK 465 ASP W 221 REMARK 465 PRO Z 219 REMARK 465 ARG Z 220 REMARK 465 ASP Z 221 REMARK 480 REMARK 480 ZERO OCCUPANCY ATOM REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME; REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 480 M RES C SSEQI ATOMS REMARK 480 LYS C 9 CD CE NZ REMARK 480 THR C 13 C REMARK 480 LYS C 45 CG CD CE NZ REMARK 480 SER C 52 CB REMARK 480 THR C 56 N O CB OG1 CG2 REMARK 480 VAL C 58 CG1 REMARK 480 ASP C 60 CB CG OD1 OD2 REMARK 480 SER C 76 C O REMARK 480 ASN C 77 ND2 REMARK 480 GLN C 79 NE2 REMARK 480 GLU C 81 OE1 REMARK 480 LEU C 106 O REMARK 480 LYS F 9 CD CE NZ REMARK 480 THR F 13 C REMARK 480 LYS F 45 CG CD CE NZ REMARK 480 SER F 52 CB REMARK 480 THR F 56 N O CB OG1 CG2 REMARK 480 VAL F 58 CG1 REMARK 480 ASP F 60 CB CG OD1 OD2 REMARK 480 SER F 76 C O REMARK 480 ASN F 77 ND2 REMARK 480 GLN F 79 NE2 REMARK 480 GLU F 81 OE1 REMARK 480 LEU F 106 O REMARK 480 LYS I 9 CD CE NZ REMARK 480 THR I 13 C REMARK 480 LYS I 45 CG CD CE NZ REMARK 480 SER I 52 CB REMARK 480 THR I 56 N O CB OG1 CG2 REMARK 480 VAL I 58 CG1 REMARK 480 ASP I 60 CB CG OD1 OD2 REMARK 480 SER I 76 C O REMARK 480 ASN I 77 ND2 REMARK 480 GLN I 79 NE2 REMARK 480 GLU I 81 OE1 REMARK 480 LEU I 106 O REMARK 480 LYS L 9 CD CE NZ REMARK 480 THR L 13 C REMARK 480 LYS L 45 CG CD CE NZ REMARK 480 SER L 52 CB REMARK 480 THR L 56 N O CB OG1 CG2 REMARK 480 VAL L 58 CG1 REMARK 480 ASP L 60 CB CG OD1 OD2 REMARK 480 SER L 76 C O REMARK 480 ASN L 77 ND2 REMARK 480 GLN L 79 NE2 REMARK 480 GLU L 81 OE1 REMARK 480 LEU L 106 O REMARK 480 LYS O 9 CD CE NZ REMARK 480 THR O 13 C REMARK 480 LYS O 45 CG CD CE NZ REMARK 480 SER O 52 CB REMARK 480 THR O 56 N O CB OG1 CG2 REMARK 480 VAL O 58 CG1 REMARK 480 ASP O 60 CB CG OD1 OD2 REMARK 480 SER O 76 C O REMARK 480 ASN O 77 ND2 REMARK 480 GLN O 79 NE2 REMARK 480 GLU O 81 OE1 REMARK 480 LEU O 106 O REMARK 480 LYS j 9 CD CE NZ REMARK 480 THR j 13 C REMARK 480 LYS j 45 CG CD CE NZ REMARK 480 SER j 52 CB REMARK 480 THR j 56 N O CB OG1 CG2 REMARK 480 VAL j 58 CG1 REMARK 480 ASP j 60 CB CG OD1 OD2 REMARK 480 SER j 76 C O REMARK 480 ASN j 77 ND2 REMARK 480 GLN j 79 NE2 REMARK 480 GLU j 81 OE1 REMARK 480 LEU j 106 O REMARK 480 LYS R 9 CD CE NZ REMARK 480 THR R 13 C REMARK 480 LYS R 45 CG CD CE NZ REMARK 480 SER R 52 CB REMARK 480 THR R 56 N O CB OG1 CG2 REMARK 480 VAL R 58 CG1 REMARK 480 ASP R 60 CB CG OD1 OD2 REMARK 480 SER R 76 C O REMARK 480 ASN R 77 ND2 REMARK 480 GLN R 79 NE2 REMARK 480 GLU R 81 OE1 REMARK 480 LEU R 106 O REMARK 480 LYS U 9 CD CE NZ REMARK 480 THR U 13 C REMARK 480 LYS U 45 CG CD CE NZ REMARK 480 SER U 52 CB REMARK 480 THR U 56 N O CB OG1 CG2 REMARK 480 VAL U 58 CG1 REMARK 480 ASP U 60 CB CG OD1 OD2 REMARK 480 SER U 76 C O REMARK 480 ASN U 77 ND2 REMARK 480 GLN U 79 NE2 REMARK 480 GLU U 81 OE1 REMARK 480 LEU U 106 O REMARK 480 LYS X 9 CD CE NZ REMARK 480 THR X 13 C REMARK 480 LYS X 45 CG CD CE NZ REMARK 480 SER X 52 CB REMARK 480 THR X 56 N O CB OG1 CG2 REMARK 480 VAL X 58 CG1 REMARK 480 ASP X 60 CB CG OD1 OD2 REMARK 480 SER X 76 C O REMARK 480 ASN X 77 ND2 REMARK 480 GLN X 79 NE2 REMARK 480 GLU X 81 OE1 REMARK 480 LEU X 106 O REMARK 480 LYS a 9 CD CE NZ REMARK 480 THR a 13 C REMARK 480 LYS a 45 CG CD CE NZ REMARK 480 SER a 52 CB REMARK 480 THR a 56 N O CB OG1 CG2 REMARK 480 VAL a 58 CG1 REMARK 480 ASP a 60 CB CG OD1 OD2 REMARK 480 SER a 76 C O REMARK 480 ASN a 77 ND2 REMARK 480 GLN a 79 NE2 REMARK 480 GLU a 81 OE1 REMARK 480 LEU a 106 O REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OE2 GLU R 105 OH TYR R 173 2.00 REMARK 500 O ARG Y 272 N SER Y 274 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 OD2 ASP S 77 NE2 HIS F 189 2545 2.05 REMARK 500 OG SER I 127 OE1 GLN Q 5 1565 2.11 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO E 108 C - N - CA ANGL. DEV. = 17.2 DEGREES REMARK 500 PRO E 108 C - N - CD ANGL. DEV. = -14.6 DEGREES REMARK 500 VAL F 58 N - CA - C ANGL. DEV. = -20.3 DEGREES REMARK 500 ASN K 77 C - N - CA ANGL. DEV. = 17.8 DEGREES REMARK 500 ASN Q 77 C - N - CA ANGL. DEV. = 15.1 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER A 32 -165.19 59.18 REMARK 500 THR A 85 -12.19 68.00 REMARK 500 TYR A 116 -82.79 -99.65 REMARK 500 ASN A 121 -70.66 -99.11 REMARK 500 SER A 122 -168.23 -166.89 REMARK 500 ASN A 166 179.46 66.41 REMARK 500 THR A 192 -112.42 -116.99 REMARK 500 PHE A 194 15.51 -153.30 REMARK 500 SER A 207 11.09 -147.84 REMARK 500 THR A 216 -158.60 -127.99 REMARK 500 SER A 269 34.97 -160.36 REMARK 500 ASN A 271 -159.92 -80.43 REMARK 500 ARG A 272 -92.74 58.46 REMARK 500 THR A 273 -34.76 53.47 REMARK 500 SER A 287 -149.97 61.95 REMARK 500 MET A 382 -136.71 66.54 REMARK 500 SER D 32 -164.77 58.88 REMARK 500 THR D 85 -12.09 68.05 REMARK 500 TYR D 116 -82.06 -100.00 REMARK 500 ASN D 121 -70.38 -99.19 REMARK 500 SER D 122 -168.62 -166.51 REMARK 500 ASN D 166 179.80 65.88 REMARK 500 THR D 192 -113.25 -115.89 REMARK 500 PHE D 194 15.86 -152.72 REMARK 500 SER D 207 11.08 -147.99 REMARK 500 THR D 216 -158.24 -128.34 REMARK 500 SER D 269 34.54 -160.89 REMARK 500 ARG D 272 -91.39 56.93 REMARK 500 THR D 273 -33.57 51.76 REMARK 500 SER D 287 -149.20 62.07 REMARK 500 MET D 382 -136.60 66.33 REMARK 500 SER G 32 -165.61 59.34 REMARK 500 THR G 85 -12.50 68.08 REMARK 500 TYR G 116 -82.66 -100.00 REMARK 500 ASN G 121 -71.41 -97.93 REMARK 500 SER G 122 -167.55 -167.49 REMARK 500 ASN G 166 -179.99 65.92 REMARK 500 THR G 192 -113.34 -116.05 REMARK 500 PHE G 194 16.02 -153.36 REMARK 500 SER G 207 10.95 -148.11 REMARK 500 THR G 216 -158.90 -128.27 REMARK 500 SER G 269 35.04 -158.74 REMARK 500 ASN G 271 -159.40 -80.31 REMARK 500 ARG G 272 -93.44 55.30 REMARK 500 THR G 273 -35.48 53.76 REMARK 500 SER G 287 -148.28 61.63 REMARK 500 MET G 382 -136.49 66.29 REMARK 500 SER J 32 -166.35 59.38 REMARK 500 THR J 85 -12.21 68.19 REMARK 500 TYR J 116 -82.32 -100.09 REMARK 500 REMARK 500 THIS ENTRY HAS 448 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 LYS B 30 ASP B 31 -41.56 REMARK 500 SER B 76 ASN B 77 50.31 REMARK 500 THR B 78 ALA B 79 40.30 REMARK 500 SER E 76 ASN E 77 138.82 REMARK 500 THR E 78 ALA E 79 35.66 REMARK 500 GLY F 57 VAL F 58 -34.60 REMARK 500 SER H 76 ASN H 77 50.62 REMARK 500 THR H 78 ALA H 79 38.42 REMARK 500 SER N 76 ASN N 77 49.77 REMARK 500 THR N 78 ALA N 79 39.79 REMARK 500 SER g 76 ASN g 77 49.43 REMARK 500 THR g 78 ALA g 79 40.37 REMARK 500 SER T 76 ASN T 77 49.56 REMARK 500 THR T 78 ALA T 79 37.40 REMARK 500 THR W 78 ALA W 79 124.32 REMARK 500 LYS Z 30 ASP Z 31 32.68 REMARK 500 THR Z 78 ALA Z 79 39.06 REMARK 500 REMARK 500 REMARK: NULL DBREF 7EW5 A -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 D -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 G -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 J -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 M -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 P -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 S -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 V -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 Y -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 b -1 493 UNP Q9W9C6 Q9W9C6_9PAPI 6 500 DBREF 7EW5 B 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 C 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 E 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 F 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 H 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 I 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 K 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 L 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 N 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 O 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 g 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 j 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 Q 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 R 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 T 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 U 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 W 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 X 1 214 PDB 7EW5 7EW5 1 214 DBREF 7EW5 Z 1 221 PDB 7EW5 7EW5 1 221 DBREF 7EW5 a 1 214 PDB 7EW5 7EW5 1 214 SEQADV 7EW5 MET A -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL A 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET D -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL D 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET G -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL G 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET J -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL J 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET M -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL M 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET P -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL P 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET S -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL S 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET V -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL V 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET Y -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL Y 376 UNP Q9W9C6 MET 383 CONFLICT SEQADV 7EW5 MET b -2 UNP Q9W9C6 INITIATING METHIONINE SEQADV 7EW5 VAL b 376 UNP Q9W9C6 MET 383 CONFLICT SEQRES 1 A 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 A 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 A 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 A 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 A 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 A 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 A 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 A 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 A 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 A 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 A 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 A 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 A 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 A 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 A 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 A 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 A 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 A 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 A 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 A 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 A 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 A 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 A 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 A 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 A 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 A 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 A 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 A 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 A 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 A 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 A 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 A 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 A 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 A 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 A 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 A 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 A 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 A 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 A 496 LYS ARG SEQRES 1 D 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 D 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 D 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 D 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 D 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 D 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 D 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 D 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 D 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 D 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 D 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 D 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 D 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 D 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 D 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 D 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 D 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 D 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 D 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 D 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 D 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 D 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 D 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 D 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 D 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 D 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 D 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 D 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 D 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 D 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 D 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 D 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 D 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 D 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 D 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 D 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 D 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 D 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 D 496 LYS ARG SEQRES 1 G 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 G 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 G 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 G 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 G 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 G 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 G 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 G 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 G 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 G 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 G 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 G 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 G 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 G 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 G 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 G 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 G 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 G 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 G 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 G 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 G 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 G 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 G 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 G 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 G 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 G 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 G 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 G 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 G 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 G 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 G 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 G 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 G 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 G 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 G 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 G 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 G 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 G 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 G 496 LYS ARG SEQRES 1 J 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 J 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 J 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 J 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 J 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 J 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 J 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 J 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 J 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 J 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 J 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 J 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 J 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 J 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 J 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 J 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 J 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 J 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 J 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 J 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 J 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 J 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 J 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 J 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 J 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 J 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 J 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 J 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 J 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 J 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 J 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 J 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 J 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 J 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 J 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 J 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 J 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 J 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 J 496 LYS ARG SEQRES 1 M 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 M 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 M 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 M 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 M 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 M 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 M 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 M 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 M 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 M 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 M 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 M 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 M 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 M 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 M 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 M 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 M 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 M 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 M 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 M 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 M 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 M 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 M 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 M 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 M 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 M 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 M 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 M 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 M 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 M 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 M 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 M 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 M 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 M 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 M 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 M 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 M 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 M 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 M 496 LYS ARG SEQRES 1 P 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 P 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 P 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 P 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 P 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 P 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 P 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 P 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 P 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 P 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 P 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 P 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 P 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 P 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 P 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 P 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 P 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 P 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 P 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 P 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 P 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 P 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 P 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 P 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 P 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 P 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 P 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 P 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 P 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 P 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 P 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 P 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 P 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 P 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 P 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 P 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 P 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 P 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 P 496 LYS ARG SEQRES 1 S 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 S 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 S 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 S 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 S 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 S 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 S 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 S 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 S 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 S 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 S 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 S 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 S 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 S 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 S 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 S 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 S 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 S 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 S 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 S 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 S 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 S 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 S 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 S 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 S 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 S 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 S 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 S 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 S 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 S 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 S 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 S 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 S 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 S 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 S 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 S 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 S 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 S 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 S 496 LYS ARG SEQRES 1 V 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 V 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 V 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 V 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 V 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 V 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 V 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 V 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 V 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 V 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 V 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 V 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 V 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 V 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 V 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 V 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 V 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 V 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 V 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 V 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 V 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 V 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 V 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 V 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 V 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 V 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 V 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 V 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 V 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 V 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 V 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 V 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 V 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 V 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 V 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 V 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 V 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 V 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 V 496 LYS ARG SEQRES 1 Y 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 Y 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 Y 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 Y 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 Y 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 Y 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 Y 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 Y 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 Y 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 Y 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 Y 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 Y 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 Y 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 Y 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 Y 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 Y 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 Y 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 Y 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 Y 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 Y 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 Y 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 Y 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 Y 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 Y 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 Y 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 Y 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 Y 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 Y 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 Y 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 Y 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 Y 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 Y 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 Y 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 Y 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 Y 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 Y 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 Y 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 Y 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 Y 496 LYS ARG SEQRES 1 b 496 MET ASP SER THR VAL TYR VAL PRO PRO PRO ASN PRO VAL SEQRES 2 b 496 SER LYS VAL VAL ALA THR ASP ALA TYR VAL THR ARG THR SEQRES 3 b 496 ASN ILE PHE TYR HIS ALA SER SER SER ARG LEU LEU ALA SEQRES 4 b 496 VAL GLY HIS PRO TYR PHE SER ILE LYS ARG ALA ASN LYS SEQRES 5 b 496 THR VAL VAL PRO LYS VAL SER GLY TYR GLN TYR ARG VAL SEQRES 6 b 496 PHE LYS VAL VAL LEU PRO ASP PRO ASN LYS PHE ALA LEU SEQRES 7 b 496 PRO ASP SER SER LEU PHE ASP PRO THR THR GLN ARG LEU SEQRES 8 b 496 VAL TRP ALA CYS THR GLY LEU GLU VAL GLY ARG GLY GLN SEQRES 9 b 496 PRO LEU GLY VAL GLY VAL SER GLY HIS PRO PHE LEU ASN SEQRES 10 b 496 LYS TYR ASP ASP VAL GLU ASN SER GLY SER GLY GLY ASN SEQRES 11 b 496 PRO GLY GLN ASP ASN ARG VAL ASN VAL GLY MET ASP TYR SEQRES 12 b 496 LYS GLN THR GLN LEU CYS MET VAL GLY CYS ALA PRO PRO SEQRES 13 b 496 LEU GLY GLU HIS TRP GLY LYS GLY LYS GLN CYS THR ASN SEQRES 14 b 496 THR PRO VAL GLN ALA GLY ASP CYS PRO PRO LEU GLU LEU SEQRES 15 b 496 ILE THR SER VAL ILE GLN ASP GLY ASP MET VAL ASP THR SEQRES 16 b 496 GLY PHE GLY ALA MET ASN PHE ALA ASP LEU GLN THR ASN SEQRES 17 b 496 LYS SER ASP VAL PRO ILE ASP ILE CYS GLY THR THR CYS SEQRES 18 b 496 LYS TYR PRO ASP TYR LEU GLN MET ALA ALA ASP PRO TYR SEQRES 19 b 496 GLY ASP ARG LEU PHE PHE PHE LEU ARG LYS GLU GLN MET SEQRES 20 b 496 PHE ALA ARG HIS PHE PHE ASN ARG ALA GLY GLU VAL GLY SEQRES 21 b 496 GLU PRO VAL PRO ASP THR LEU ILE ILE LYS GLY SER GLY SEQRES 22 b 496 ASN ARG THR SER VAL GLY SER SER ILE TYR VAL ASN THR SEQRES 23 b 496 PRO SER GLY SER LEU VAL SER SER GLU ALA GLN LEU PHE SEQRES 24 b 496 ASN LYS PRO TYR TRP LEU GLN LYS ALA GLN GLY HIS ASN SEQRES 25 b 496 ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL THR VAL SEQRES 26 b 496 VAL ASP THR THR ARG SER THR ASN MET THR LEU CYS ALA SEQRES 27 b 496 SER VAL THR THR SER SER THR TYR THR ASN SER ASP TYR SEQRES 28 b 496 LYS GLU TYR MET ARG HIS VAL GLU GLU TYR ASP LEU GLN SEQRES 29 b 496 PHE ILE PHE GLN LEU CYS SER ILE THR LEU SER ALA GLU SEQRES 30 b 496 VAL VAL ALA TYR ILE HIS THR MET ASN PRO SER VAL LEU SEQRES 31 b 496 GLU ASP TRP ASN PHE GLY LEU SER PRO PRO PRO ASN GLY SEQRES 32 b 496 THR LEU GLU ASP THR TYR ARG TYR VAL GLN SER GLN ALA SEQRES 33 b 496 ILE THR CYS GLN LYS PRO THR PRO GLU LYS GLN LYS PRO SEQRES 34 b 496 ASP PRO TYR LYS ASN LEU SER PHE TRP GLU VAL ASN LEU SEQRES 35 b 496 LYS GLU LYS PHE SER SER GLU LEU ASP GLN TYR PRO LEU SEQRES 36 b 496 GLY ARG LYS PHE LEU LEU GLN SER GLY TYR ARG GLY ARG SEQRES 37 b 496 SER SER ILE ARG THR GLY VAL LYS ARG PRO ALA VAL SER SEQRES 38 b 496 LYS ALA SER ALA ALA PRO LYS ARG LYS ARG ALA LYS THR SEQRES 39 b 496 LYS ARG SEQRES 1 B 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 B 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 B 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 B 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 B 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 B 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 B 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 B 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 B 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 B 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 B 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 B 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 B 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 B 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 B 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 B 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 B 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 C 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 C 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 C 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 C 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 C 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 C 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 C 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 C 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 C 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 C 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 C 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 C 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 C 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 C 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 C 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 C 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 C 214 PHE ASN ARG ASN GLU CYS SEQRES 1 E 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 E 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 E 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 E 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 E 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 E 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 E 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 E 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 E 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 E 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 E 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 E 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 E 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 E 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 E 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 E 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 E 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 F 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 F 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 F 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 F 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 F 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 F 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 F 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 F 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 F 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 F 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 F 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 F 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 F 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 F 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 F 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 F 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 F 214 PHE ASN ARG ASN GLU CYS SEQRES 1 H 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 H 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 H 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 H 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 H 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 H 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 H 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 H 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 H 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 H 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 H 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 H 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 H 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 H 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 H 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 H 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 H 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 I 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 I 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 I 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 I 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 I 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 I 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 I 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 I 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 I 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 I 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 I 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 I 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 I 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 I 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 I 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 I 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 I 214 PHE ASN ARG ASN GLU CYS SEQRES 1 K 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 K 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 K 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 K 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 K 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 K 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 K 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 K 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 K 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 K 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 K 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 K 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 K 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 K 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 K 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 K 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 K 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 L 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 L 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 L 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 L 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 L 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 L 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 L 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 L 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 L 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 L 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 L 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 L 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 L 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 L 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 L 214 PHE ASN ARG ASN GLU CYS SEQRES 1 N 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 N 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 N 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 N 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 N 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 N 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 N 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 N 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 N 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 N 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 N 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 N 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 N 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 N 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 N 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 N 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 N 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 O 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 O 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 O 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 O 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 O 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 O 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 O 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 O 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 O 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 O 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 O 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 O 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 O 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 O 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 O 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 O 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 O 214 PHE ASN ARG ASN GLU CYS SEQRES 1 g 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 g 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 g 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 g 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 g 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 g 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 g 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 g 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 g 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 g 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 g 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 g 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 g 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 g 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 g 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 g 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 g 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 j 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 j 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 j 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 j 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 j 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 j 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 j 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 j 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 j 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 j 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 j 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 j 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 j 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 j 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 j 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 j 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 j 214 PHE ASN ARG ASN GLU CYS SEQRES 1 Q 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 Q 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 Q 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 Q 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 Q 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 Q 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 Q 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 Q 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 Q 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 Q 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 Q 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 Q 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 Q 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 Q 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 Q 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 Q 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 Q 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 R 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 R 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 R 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 R 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 R 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 R 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 R 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 R 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 R 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 R 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 R 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 R 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 R 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 R 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 R 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 R 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 R 214 PHE ASN ARG ASN GLU CYS SEQRES 1 T 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 T 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 T 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 T 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 T 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 T 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 T 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 T 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 T 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 T 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 T 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 T 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 T 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 T 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 T 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 T 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 T 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 U 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 U 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 U 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 U 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 U 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 U 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 U 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 U 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 U 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 U 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 U 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 U 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 U 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 U 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 U 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 U 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 U 214 PHE ASN ARG ASN GLU CYS SEQRES 1 W 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 W 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 W 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 W 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 W 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 W 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 W 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 W 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 W 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 W 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 W 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 W 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 W 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 W 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 W 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 W 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 W 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 X 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 X 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 X 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 X 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 X 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 X 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 X 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 X 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 X 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 X 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 X 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 X 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 X 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 X 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 X 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 X 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 X 214 PHE ASN ARG ASN GLU CYS SEQRES 1 Z 221 GLU VAL GLN LEU GLN GLN SER GLY ALA GLU VAL VAL ARG SEQRES 2 Z 221 SER GLY ALA SER VAL LYS LEU SER CYS THR ALA SER GLY SEQRES 3 Z 221 PHE ASN ILE LYS ASP TYR ALA ILE HIS TRP VAL LYS GLN SEQRES 4 Z 221 ARG PRO GLU LYS GLY LEU GLU TRP ILE GLY ALA ILE ASP SEQRES 5 Z 221 PRO GLU TYR GLY ASP THR GLU TYR VAL PRO LYS PHE GLN SEQRES 6 Z 221 GLY LYS ALA THR MET THR ALA ASP THR SER SER ASN THR SEQRES 7 Z 221 ALA TYR LEU GLN LEU SER SER LEU THR SER GLU ASP THR SEQRES 8 Z 221 ALA VAL TYR TYR CYS ASN ALA GLY HIS ASP TYR ASP ARG SEQRES 9 Z 221 GLY ARG PHE PRO TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 Z 221 VAL SER ALA ALA LYS THR THR PRO PRO SER VAL TYR PRO SEQRES 11 Z 221 LEU ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL SEQRES 12 Z 221 THR LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO SEQRES 13 Z 221 VAL THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY SEQRES 14 Z 221 VAL HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR SEQRES 15 Z 221 THR LEU SER SER SER VAL THR VAL PRO SER SER THR TRP SEQRES 16 Z 221 PRO SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SEQRES 17 Z 221 SER SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP SEQRES 1 a 214 ASP ILE VAL MET THR GLN SER GLN LYS PHE MET SER THR SEQRES 2 a 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 a 214 GLN ASN VAL GLY THR ALA VAL ALA TRP TYR GLN GLN LYS SEQRES 4 a 214 PRO GLY GLN SER PRO LYS LEU MET ILE TYR PHE ALA SER SEQRES 5 a 214 ASN ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 a 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER ASN MET SEQRES 7 a 214 GLN SER GLU ASP LEU ALA ASP TYR PHE CYS GLN GLN TYR SEQRES 8 a 214 SER SER TYR PRO LEU THR PHE GLY ALA GLY THR LYS LEU SEQRES 9 a 214 GLU LEU LYS ARG ALA ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 a 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 a 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 a 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 a 214 ASN GLY VAL LEU ASN SER ALA THR ASP GLN ASP SER LYS SEQRES 14 a 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 a 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 a 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 a 214 PHE ASN ARG ASN GLU CYS HELIX 1 AA1 ALA A 15 TYR A 19 5 5 HELIX 2 AA2 ASP A 69 PHE A 73 5 5 HELIX 3 AA3 ASP A 77 PHE A 81 5 5 HELIX 4 AA4 ASN A 198 GLN A 203 1 6 HELIX 5 AA5 ASP A 222 ASP A 229 1 8 HELIX 6 AA6 PRO A 261 ILE A 265 5 5 HELIX 7 AA7 GLU A 292 GLN A 294 5 3 HELIX 8 AA8 CYS A 313 GLY A 315 5 3 HELIX 9 AA9 THR A 344 SER A 346 5 3 HELIX 10 AB1 SER A 372 THR A 381 1 10 HELIX 11 AB2 PRO A 384 TRP A 390 1 7 HELIX 12 AB3 ASP A 427 ASN A 431 5 5 HELIX 13 AB4 GLU A 446 GLN A 449 5 4 HELIX 14 AB5 TYR A 450 LEU A 458 1 9 HELIX 15 AB6 ALA D 15 TYR D 19 5 5 HELIX 16 AB7 ASP D 69 PHE D 73 5 5 HELIX 17 AB8 ASP D 77 PHE D 81 5 5 HELIX 18 AB9 ASN D 198 GLN D 203 1 6 HELIX 19 AC1 ASP D 222 ASP D 229 1 8 HELIX 20 AC2 PRO D 261 ILE D 265 5 5 HELIX 21 AC3 GLU D 292 GLN D 294 5 3 HELIX 22 AC4 CYS D 313 GLY D 315 5 3 HELIX 23 AC5 THR D 344 SER D 346 5 3 HELIX 24 AC6 SER D 372 THR D 381 1 10 HELIX 25 AC7 PRO D 384 TRP D 390 1 7 HELIX 26 AC8 ASP D 427 ASN D 431 5 5 HELIX 27 AC9 GLU D 446 GLN D 449 5 4 HELIX 28 AD1 TYR D 450 LEU D 458 1 9 HELIX 29 AD2 ALA G 15 TYR G 19 5 5 HELIX 30 AD3 ASP G 69 PHE G 73 5 5 HELIX 31 AD4 ASP G 77 PHE G 81 5 5 HELIX 32 AD5 ASN G 198 GLN G 203 1 6 HELIX 33 AD6 ASP G 222 ASP G 229 1 8 HELIX 34 AD7 PRO G 261 ILE G 265 5 5 HELIX 35 AD8 CYS G 313 GLY G 315 5 3 HELIX 36 AD9 THR G 344 SER G 346 5 3 HELIX 37 AE1 SER G 372 THR G 381 1 10 HELIX 38 AE2 PRO G 384 TRP G 390 1 7 HELIX 39 AE3 ASP G 427 ASN G 431 5 5 HELIX 40 AE4 GLU G 446 GLN G 449 5 4 HELIX 41 AE5 TYR G 450 LEU G 458 1 9 HELIX 42 AE6 ALA J 15 TYR J 19 5 5 HELIX 43 AE7 ASP J 69 PHE J 73 5 5 HELIX 44 AE8 ASP J 77 PHE J 81 5 5 HELIX 45 AE9 ASN J 198 GLN J 203 1 6 HELIX 46 AF1 ASP J 222 ALA J 228 1 7 HELIX 47 AF2 PRO J 261 ILE J 265 5 5 HELIX 48 AF3 CYS J 313 GLY J 315 5 3 HELIX 49 AF4 THR J 344 SER J 346 5 3 HELIX 50 AF5 SER J 372 THR J 381 1 10 HELIX 51 AF6 PRO J 384 TRP J 390 1 7 HELIX 52 AF7 ASP J 427 ASN J 431 5 5 HELIX 53 AF8 GLU J 446 GLN J 449 5 4 HELIX 54 AF9 TYR J 450 LEU J 458 1 9 HELIX 55 AG1 ALA M 15 TYR M 19 5 5 HELIX 56 AG2 ASP M 69 PHE M 73 5 5 HELIX 57 AG3 ASP M 77 PHE M 81 5 5 HELIX 58 AG4 ASN M 198 GLN M 203 1 6 HELIX 59 AG5 ASP M 222 ALA M 228 1 7 HELIX 60 AG6 PRO M 261 ILE M 265 5 5 HELIX 61 AG7 GLU M 292 GLN M 294 5 3 HELIX 62 AG8 CYS M 313 GLY M 315 5 3 HELIX 63 AG9 THR M 344 SER M 346 5 3 HELIX 64 AH1 SER M 372 THR M 381 1 10 HELIX 65 AH2 PRO M 384 TRP M 390 1 7 HELIX 66 AH3 ASP M 427 ASN M 431 5 5 HELIX 67 AH4 GLU M 446 GLN M 449 5 4 HELIX 68 AH5 TYR M 450 LEU M 458 1 9 HELIX 69 AH6 ALA P 15 TYR P 19 5 5 HELIX 70 AH7 ASP P 69 PHE P 73 5 5 HELIX 71 AH8 ASP P 77 PHE P 81 5 5 HELIX 72 AH9 ASN P 198 GLN P 203 1 6 HELIX 73 AI1 ASP P 222 ASP P 229 1 8 HELIX 74 AI2 PRO P 261 ILE P 265 5 5 HELIX 75 AI3 CYS P 313 GLY P 315 5 3 HELIX 76 AI4 THR P 344 SER P 346 5 3 HELIX 77 AI5 SER P 372 THR P 381 1 10 HELIX 78 AI6 PRO P 384 TRP P 390 1 7 HELIX 79 AI7 ASP P 427 LEU P 432 5 6 HELIX 80 AI8 GLU P 446 GLN P 449 5 4 HELIX 81 AI9 TYR P 450 LEU P 458 1 9 HELIX 82 AJ1 ALA S 15 TYR S 19 5 5 HELIX 83 AJ2 ASP S 69 PHE S 73 5 5 HELIX 84 AJ3 ASP S 77 PHE S 81 5 5 HELIX 85 AJ4 ASN S 198 GLN S 203 1 6 HELIX 86 AJ5 ASP S 222 ALA S 228 1 7 HELIX 87 AJ6 PRO S 261 ILE S 265 5 5 HELIX 88 AJ7 CYS S 313 GLY S 315 5 3 HELIX 89 AJ8 THR S 344 SER S 346 5 3 HELIX 90 AJ9 SER S 372 THR S 381 1 10 HELIX 91 AK1 PRO S 384 TRP S 390 1 7 HELIX 92 AK2 ASP S 427 ASN S 431 5 5 HELIX 93 AK3 GLU S 446 GLN S 449 5 4 HELIX 94 AK4 TYR S 450 LEU S 458 1 9 HELIX 95 AK5 ALA V 15 TYR V 19 5 5 HELIX 96 AK6 ASP V 69 PHE V 73 5 5 HELIX 97 AK7 ASP V 77 PHE V 81 5 5 HELIX 98 AK8 ASN V 198 GLN V 203 1 6 HELIX 99 AK9 ASP V 222 ASP V 229 1 8 HELIX 100 AL1 PRO V 261 ILE V 265 5 5 HELIX 101 AL2 GLU V 292 GLN V 294 5 3 HELIX 102 AL3 CYS V 313 GLY V 315 5 3 HELIX 103 AL4 THR V 344 SER V 346 5 3 HELIX 104 AL5 SER V 372 THR V 381 1 10 HELIX 105 AL6 PRO V 384 TRP V 390 1 7 HELIX 106 AL7 ASP V 427 ASN V 431 5 5 HELIX 107 AL8 GLU V 446 GLN V 449 5 4 HELIX 108 AL9 TYR V 450 LEU V 458 1 9 HELIX 109 AM1 ALA Y 15 TYR Y 19 5 5 HELIX 110 AM2 ASP Y 69 PHE Y 73 5 5 HELIX 111 AM3 ASP Y 77 PHE Y 81 5 5 HELIX 112 AM4 ASN Y 198 GLN Y 203 1 6 HELIX 113 AM5 ASP Y 222 ASP Y 229 1 8 HELIX 114 AM6 PRO Y 261 ILE Y 265 5 5 HELIX 115 AM7 GLU Y 292 GLN Y 294 5 3 HELIX 116 AM8 CYS Y 313 GLY Y 315 5 3 HELIX 117 AM9 THR Y 344 SER Y 346 5 3 HELIX 118 AN1 SER Y 372 THR Y 381 1 10 HELIX 119 AN2 PRO Y 384 TRP Y 390 1 7 HELIX 120 AN3 ASP Y 427 LEU Y 432 5 6 HELIX 121 AN4 GLU Y 446 GLN Y 449 5 4 HELIX 122 AN5 TYR Y 450 LEU Y 458 1 9 HELIX 123 AN6 ALA b 15 TYR b 19 5 5 HELIX 124 AN7 ASP b 69 PHE b 73 5 5 HELIX 125 AN8 ASP b 77 PHE b 81 5 5 HELIX 126 AN9 ASN b 198 GLN b 203 1 6 HELIX 127 AO1 ASP b 222 ASP b 229 1 8 HELIX 128 AO2 PRO b 261 ILE b 265 5 5 HELIX 129 AO3 GLU b 292 GLN b 294 5 3 HELIX 130 AO4 CYS b 313 GLY b 315 5 3 HELIX 131 AO5 THR b 344 SER b 346 5 3 HELIX 132 AO6 SER b 372 THR b 381 1 10 HELIX 133 AO7 PRO b 384 TRP b 390 1 7 HELIX 134 AO8 ASP b 427 LEU b 432 5 6 HELIX 135 AO9 GLU b 446 GLN b 449 5 4 HELIX 136 AP1 TYR b 450 LEU b 458 1 9 HELIX 137 AP2 THR B 87 THR B 91 5 5 HELIX 138 AP3 GLN C 79 LEU C 83 5 5 HELIX 139 AP4 GLU C 123 SER C 127 5 5 HELIX 140 AP5 LYS C 183 GLU C 187 1 5 HELIX 141 AP6 THR E 87 THR E 91 5 5 HELIX 142 AP7 GLN F 79 LEU F 83 5 5 HELIX 143 AP8 GLU F 123 SER F 127 5 5 HELIX 144 AP9 LYS F 183 GLU F 187 1 5 HELIX 145 AQ1 THR H 87 THR H 91 5 5 HELIX 146 AQ2 GLN I 79 LEU I 83 5 5 HELIX 147 AQ3 GLU I 123 SER I 127 5 5 HELIX 148 AQ4 LYS I 183 GLU I 187 1 5 HELIX 149 AQ5 THR K 87 THR K 91 5 5 HELIX 150 AQ6 GLN L 79 LEU L 83 5 5 HELIX 151 AQ7 GLU L 123 SER L 127 5 5 HELIX 152 AQ8 LYS L 183 GLU L 187 1 5 HELIX 153 AQ9 THR N 87 THR N 91 5 5 HELIX 154 AR1 GLN O 79 LEU O 83 5 5 HELIX 155 AR2 GLU O 123 SER O 127 5 5 HELIX 156 AR3 LYS O 183 GLU O 187 1 5 HELIX 157 AR4 THR g 87 THR g 91 5 5 HELIX 158 AR5 GLN j 79 LEU j 83 5 5 HELIX 159 AR6 GLU j 123 SER j 127 5 5 HELIX 160 AR7 LYS j 183 GLU j 187 1 5 HELIX 161 AR8 THR Q 87 THR Q 91 5 5 HELIX 162 AR9 GLN R 79 LEU R 83 5 5 HELIX 163 AS1 GLU R 123 SER R 127 5 5 HELIX 164 AS2 LYS R 183 GLU R 187 1 5 HELIX 165 AS3 THR T 87 THR T 91 5 5 HELIX 166 AS4 GLN U 79 LEU U 83 5 5 HELIX 167 AS5 GLU U 123 SER U 127 5 5 HELIX 168 AS6 LYS U 183 GLU U 187 1 5 HELIX 169 AS7 THR W 87 THR W 91 5 5 HELIX 170 AS8 GLN X 79 LEU X 83 5 5 HELIX 171 AS9 GLU X 123 SER X 127 5 5 HELIX 172 AT1 LYS X 183 GLU X 187 1 5 HELIX 173 AT2 THR Z 87 THR Z 91 5 5 HELIX 174 AT3 GLN a 79 LEU a 83 5 5 HELIX 175 AT4 GLU a 123 SER a 127 5 5 HELIX 176 AT5 LYS a 183 GLU a 187 1 5 SHEET 1 AA1 7 THR A 21 SER A 30 0 SHEET 2 AA1 7 LEU A 34 GLY A 38 0 SHEET 3 AA1 7 GLN A 86 ARG A 99 0 SHEET 4 AA1 7 TYR A 300 TRP A 301 -1 O TYR A 300 N LEU A 95 SHEET 5 AA1 7 MET A 331 SER A 336 0 SHEET 6 AA1 7 TYR A 348 THR A 370 -1 O TYR A 351 N LEU A 333 SHEET 7 AA1 7 GLU M 255 VAL M 256 1 O GLU M 255 N GLU A 350 SHEET 1 AA2 2 ILE A 44 LYS A 45 0 SHEET 2 AA2 2 THR A 50 VAL A 52 -1 O VAL A 51 N ILE A 44 SHEET 1 AA3 7 ARG A 61 VAL A 66 0 SHEET 2 AA3 7 GLN A 142 GLY A 149 0 SHEET 3 AA3 7 PHE A 237 ASN A 251 -1 O LYS A 241 N GLN A 144 SHEET 4 AA3 7 TYR A 280 SER A 285 -1 O THR A 283 N ARG A 247 SHEET 5 AA3 7 GLN A 317 ASP A 324 -1 O PHE A 319 N GLY A 149 SHEET 6 AA3 7 TRP A 435 ASN A 438 1 O TRP A 435 N VAL A 62 SHEET 7 AA3 7 VAL D 289 SER D 290 -1 O VAL D 289 N MET A 244 SHEET 1 AA4 2 VAL A 107 LEU A 113 0 SHEET 2 AA4 2 VAL A 134 ASP A 139 -1 O MET A 138 N SER A 108 SHEET 1 AA5 4 LEU A 177 VAL A 183 0 SHEET 2 AA5 4 LEU A 154 LYS A 160 -1 N HIS A 157 O ILE A 180 SHEET 3 AA5 4 CYS A 218 PRO A 221 -1 O TYR A 220 N GLU A 156 SHEET 4 AA5 4 MET A 189 VAL A 190 1 N MET A 189 O LYS A 219 SHEET 1 AA6 7 GLU A 255 VAL A 256 0 SHEET 2 AA6 7 THR D 21 SER D 30 0 SHEET 3 AA6 7 LEU D 34 GLY D 38 0 SHEET 4 AA6 7 GLN D 86 ARG D 99 0 SHEET 5 AA6 7 TYR D 300 TRP D 301 -1 O TYR D 300 N LEU D 95 SHEET 6 AA6 7 MET D 331 SER D 336 0 SHEET 7 AA6 7 TYR D 348 THR D 370 -1 O TYR D 351 N LEU D 333 SHEET 1 AA7 7 VAL A 289 SER A 290 0 SHEET 2 AA7 7 ARG M 61 VAL M 66 0 SHEET 3 AA7 7 GLN M 142 GLY M 149 0 SHEET 4 AA7 7 PHE M 237 ASN M 251 -1 O LYS M 241 N GLN M 144 SHEET 5 AA7 7 TYR M 280 SER M 285 -1 O THR M 283 N ARG M 247 SHEET 6 AA7 7 GLN M 317 ASP M 324 -1 O PHE M 319 N GLY M 149 SHEET 7 AA7 7 TRP M 435 ASN M 438 1 O TRP M 435 N VAL M 62 SHEET 1 AA8 2 ILE D 44 LYS D 45 0 SHEET 2 AA8 2 THR D 50 VAL D 52 -1 O VAL D 51 N ILE D 44 SHEET 1 AA9 7 ARG D 61 VAL D 66 0 SHEET 2 AA9 7 GLN D 142 GLY D 149 0 SHEET 3 AA9 7 PHE D 237 ASN D 251 -1 O LYS D 241 N GLN D 144 SHEET 4 AA9 7 TYR D 280 SER D 285 -1 O THR D 283 N ARG D 247 SHEET 5 AA9 7 GLN D 317 ASP D 324 -1 O PHE D 319 N GLY D 149 SHEET 6 AA9 7 TRP D 435 ASN D 438 1 O TRP D 435 N VAL D 62 SHEET 7 AA9 7 VAL G 289 SER G 290 -1 O VAL G 289 N MET D 244 SHEET 1 AB1 2 VAL D 107 LEU D 113 0 SHEET 2 AB1 2 VAL D 134 ASP D 139 -1 O MET D 138 N SER D 108 SHEET 1 AB2 3 LEU D 177 VAL D 183 0 SHEET 2 AB2 3 LEU D 154 LYS D 160 -1 N HIS D 157 O ILE D 180 SHEET 3 AB2 3 TYR D 220 PRO D 221 -1 O TYR D 220 N GLU D 156 SHEET 1 AB3 6 GLU D 255 VAL D 256 0 SHEET 2 AB3 6 THR G 21 GLY G 38 0 SHEET 3 AB3 6 GLN G 86 ARG G 99 0 SHEET 4 AB3 6 TYR G 300 TRP G 301 -1 O TYR G 300 N LEU G 95 SHEET 5 AB3 6 MET G 331 SER G 336 0 SHEET 6 AB3 6 TYR G 348 THR G 370 -1 O TYR G 351 N LEU G 333 SHEET 1 AB4 2 ILE G 44 LYS G 45 0 SHEET 2 AB4 2 THR G 50 VAL G 52 -1 O VAL G 51 N ILE G 44 SHEET 1 AB5 7 ARG G 61 VAL G 66 0 SHEET 2 AB5 7 GLN G 142 GLY G 149 0 SHEET 3 AB5 7 PHE G 237 ASN G 251 -1 O LYS G 241 N GLN G 144 SHEET 4 AB5 7 TYR G 280 SER G 285 -1 O THR G 283 N ARG G 247 SHEET 5 AB5 7 GLN G 317 ASP G 324 -1 O PHE G 319 N GLY G 149 SHEET 6 AB5 7 TRP G 435 ASN G 438 1 O VAL G 437 N LYS G 64 SHEET 7 AB5 7 VAL J 289 SER J 290 -1 O VAL J 289 N MET G 244 SHEET 1 AB6 2 SER G 108 LEU G 113 0 SHEET 2 AB6 2 VAL G 134 MET G 138 -1 O MET G 138 N SER G 108 SHEET 1 AB7 4 LEU G 177 VAL G 183 0 SHEET 2 AB7 4 LEU G 154 LYS G 160 -1 N HIS G 157 O ILE G 180 SHEET 3 AB7 4 CYS G 218 PRO G 221 -1 O TYR G 220 N GLU G 156 SHEET 4 AB7 4 MET G 189 VAL G 190 1 N MET G 189 O LYS G 219 SHEET 1 AB8 6 GLU G 255 VAL G 256 0 SHEET 2 AB8 6 THR J 21 GLY J 38 0 SHEET 3 AB8 6 GLN J 86 ARG J 99 0 SHEET 4 AB8 6 TYR J 300 TRP J 301 -1 O TYR J 300 N LEU J 95 SHEET 5 AB8 6 MET J 331 SER J 336 0 SHEET 6 AB8 6 TYR J 348 THR J 370 -1 O TYR J 351 N LEU J 333 SHEET 1 AB9 2 ILE J 44 LYS J 45 0 SHEET 2 AB9 2 THR J 50 VAL J 52 -1 O VAL J 51 N ILE J 44 SHEET 1 AC1 7 ARG J 61 VAL J 66 0 SHEET 2 AC1 7 GLN J 142 GLY J 149 0 SHEET 3 AC1 7 PHE J 237 ASN J 251 -1 O LYS J 241 N GLN J 144 SHEET 4 AC1 7 TYR J 280 SER J 285 -1 O THR J 283 N ARG J 247 SHEET 5 AC1 7 GLN J 317 ASP J 324 -1 O PHE J 319 N GLY J 149 SHEET 6 AC1 7 TRP J 435 ASN J 438 1 O TRP J 435 N VAL J 62 SHEET 7 AC1 7 VAL M 289 SER M 290 -1 O VAL M 289 N MET J 244 SHEET 1 AC2 2 SER J 108 LEU J 113 0 SHEET 2 AC2 2 VAL J 134 MET J 138 -1 O MET J 138 N SER J 108 SHEET 1 AC3 4 LEU J 177 VAL J 183 0 SHEET 2 AC3 4 LEU J 154 LYS J 160 -1 N HIS J 157 O ILE J 180 SHEET 3 AC3 4 CYS J 218 PRO J 221 -1 O TYR J 220 N GLU J 156 SHEET 4 AC3 4 MET J 189 VAL J 190 1 N MET J 189 O LYS J 219 SHEET 1 AC4 7 GLU J 255 VAL J 256 0 SHEET 2 AC4 7 THR M 21 SER M 30 0 SHEET 3 AC4 7 LEU M 34 GLY M 38 0 SHEET 4 AC4 7 GLN M 86 ARG M 99 0 SHEET 5 AC4 7 TYR M 300 TRP M 301 -1 O TYR M 300 N LEU M 95 SHEET 6 AC4 7 MET M 331 SER M 336 0 SHEET 7 AC4 7 TYR M 348 THR M 370 -1 O LYS M 349 N ALA M 335 SHEET 1 AC5 2 ILE M 44 LYS M 45 0 SHEET 2 AC5 2 THR M 50 VAL M 52 -1 O VAL M 51 N ILE M 44 SHEET 1 AC6 2 VAL M 107 LEU M 113 0 SHEET 2 AC6 2 VAL M 134 ASP M 139 -1 O MET M 138 N SER M 108 SHEET 1 AC7 4 LEU M 177 VAL M 183 0 SHEET 2 AC7 4 LEU M 154 LYS M 160 -1 N GLY M 155 O SER M 182 SHEET 3 AC7 4 CYS M 218 PRO M 221 -1 O TYR M 220 N GLU M 156 SHEET 4 AC7 4 MET M 189 VAL M 190 1 N MET M 189 O LYS M 219 SHEET 1 AC8 7 THR P 21 SER P 30 0 SHEET 2 AC8 7 LEU P 34 GLY P 38 0 SHEET 3 AC8 7 GLN P 86 ARG P 99 0 SHEET 4 AC8 7 TYR P 300 TRP P 301 -1 O TYR P 300 N LEU P 95 SHEET 5 AC8 7 MET P 331 SER P 336 0 SHEET 6 AC8 7 TYR P 348 THR P 370 -1 O LYS P 349 N ALA P 335 SHEET 7 AC8 7 GLU b 255 VAL b 256 1 O GLU b 255 N GLU P 350 SHEET 1 AC9 2 ILE P 44 LYS P 45 0 SHEET 2 AC9 2 THR P 50 VAL P 52 -1 O VAL P 51 N ILE P 44 SHEET 1 AD1 7 ARG P 61 VAL P 66 0 SHEET 2 AD1 7 GLN P 142 GLY P 149 0 SHEET 3 AD1 7 PHE P 237 ASN P 251 -1 O LYS P 241 N GLN P 144 SHEET 4 AD1 7 TYR P 280 SER P 285 -1 O THR P 283 N ARG P 247 SHEET 5 AD1 7 GLN P 317 ASP P 324 -1 O PHE P 319 N GLY P 149 SHEET 6 AD1 7 TRP P 435 ASN P 438 1 O TRP P 435 N VAL P 62 SHEET 7 AD1 7 VAL S 289 SER S 290 -1 O VAL S 289 N MET P 244 SHEET 1 AD2 2 VAL P 107 LEU P 113 0 SHEET 2 AD2 2 VAL P 134 ASP P 139 -1 O MET P 138 N SER P 108 SHEET 1 AD3 4 LEU P 177 VAL P 183 0 SHEET 2 AD3 4 LEU P 154 LYS P 160 -1 N HIS P 157 O ILE P 180 SHEET 3 AD3 4 CYS P 218 PRO P 221 -1 O TYR P 220 N GLU P 156 SHEET 4 AD3 4 MET P 189 VAL P 190 1 N MET P 189 O LYS P 219 SHEET 1 AD4 7 GLU P 255 VAL P 256 0 SHEET 2 AD4 7 THR S 21 SER S 30 0 SHEET 3 AD4 7 LEU S 34 GLY S 38 0 SHEET 4 AD4 7 GLN S 86 ARG S 99 0 SHEET 5 AD4 7 TYR S 300 TRP S 301 -1 O TYR S 300 N LEU S 95 SHEET 6 AD4 7 MET S 331 SER S 336 0 SHEET 7 AD4 7 TYR S 348 THR S 370 -1 O TYR S 351 N LEU S 333 SHEET 1 AD5 7 VAL P 289 SER P 290 0 SHEET 2 AD5 7 ARG b 61 VAL b 66 0 SHEET 3 AD5 7 GLN b 142 GLY b 149 0 SHEET 4 AD5 7 PHE b 237 ASN b 251 -1 O LYS b 241 N GLN b 144 SHEET 5 AD5 7 TYR b 280 SER b 285 -1 O THR b 283 N ARG b 247 SHEET 6 AD5 7 GLN b 317 ASP b 324 -1 O PHE b 319 N GLY b 149 SHEET 7 AD5 7 TRP b 435 ASN b 438 1 O VAL b 437 N LYS b 64 SHEET 1 AD6 2 ILE S 44 LYS S 45 0 SHEET 2 AD6 2 THR S 50 VAL S 52 -1 O VAL S 51 N ILE S 44 SHEET 1 AD7 6 TRP S 435 ASN S 438 0 SHEET 2 AD7 6 ARG S 61 VAL S 66 1 N VAL S 62 O TRP S 435 SHEET 3 AD7 6 GLN S 317 ASP S 324 -1 O VAL S 320 N PHE S 63 SHEET 4 AD7 6 GLN S 142 GLY S 149 -1 N GLY S 149 O PHE S 319 SHEET 5 AD7 6 PHE S 237 MET S 244 -1 O LYS S 241 N GLN S 144 SHEET 6 AD7 6 VAL V 289 SER V 290 -1 O VAL V 289 N MET S 244 SHEET 1 AD8 2 VAL S 107 LEU S 113 0 SHEET 2 AD8 2 VAL S 134 ASP S 139 -1 O MET S 138 N SER S 108 SHEET 1 AD9 4 LEU S 177 VAL S 183 0 SHEET 2 AD9 4 LEU S 154 LYS S 160 -1 N HIS S 157 O ILE S 180 SHEET 3 AD9 4 CYS S 218 PRO S 221 -1 O TYR S 220 N GLU S 156 SHEET 4 AD9 4 MET S 189 VAL S 190 1 N MET S 189 O LYS S 219 SHEET 1 AE1 2 PHE S 249 ASN S 251 0 SHEET 2 AE1 2 TYR S 280 ASN S 282 -1 O VAL S 281 N PHE S 250 SHEET 1 AE2 6 GLU S 255 VAL S 256 0 SHEET 2 AE2 6 THR V 21 GLY V 38 0 SHEET 3 AE2 6 GLN V 86 ARG V 99 0 SHEET 4 AE2 6 TYR V 300 TRP V 301 -1 O TYR V 300 N LEU V 95 SHEET 5 AE2 6 MET V 331 SER V 336 0 SHEET 6 AE2 6 TYR V 348 THR V 370 -1 O LYS V 349 N ALA V 335 SHEET 1 AE3 2 ILE V 44 LYS V 45 0 SHEET 2 AE3 2 THR V 50 VAL V 52 -1 O VAL V 51 N ILE V 44 SHEET 1 AE4 7 ARG V 61 VAL V 66 0 SHEET 2 AE4 7 GLN V 142 GLY V 149 0 SHEET 3 AE4 7 PHE V 237 ASN V 251 -1 O LYS V 241 N GLN V 144 SHEET 4 AE4 7 TYR V 280 SER V 285 -1 O THR V 283 N ARG V 247 SHEET 5 AE4 7 GLN V 317 ASP V 324 -1 O PHE V 319 N GLY V 149 SHEET 6 AE4 7 TRP V 435 ASN V 438 1 O VAL V 437 N LYS V 64 SHEET 7 AE4 7 VAL Y 289 SER Y 290 -1 O VAL Y 289 N MET V 244 SHEET 1 AE5 2 VAL V 107 LEU V 113 0 SHEET 2 AE5 2 VAL V 134 ASP V 139 -1 O MET V 138 N SER V 108 SHEET 1 AE6 4 LEU V 177 VAL V 183 0 SHEET 2 AE6 4 LEU V 154 LYS V 160 -1 N HIS V 157 O ILE V 180 SHEET 3 AE6 4 CYS V 218 PRO V 221 -1 O TYR V 220 N GLU V 156 SHEET 4 AE6 4 MET V 189 VAL V 190 1 N MET V 189 O LYS V 219 SHEET 1 AE7 6 GLU V 255 VAL V 256 0 SHEET 2 AE7 6 THR Y 21 GLY Y 38 0 SHEET 3 AE7 6 GLN Y 86 ARG Y 99 0 SHEET 4 AE7 6 TYR Y 300 TRP Y 301 -1 O TYR Y 300 N LEU Y 95 SHEET 5 AE7 6 MET Y 331 SER Y 336 0 SHEET 6 AE7 6 TYR Y 348 THR Y 370 -1 O LYS Y 349 N ALA Y 335 SHEET 1 AE8 2 ILE Y 44 LYS Y 45 0 SHEET 2 AE8 2 THR Y 50 VAL Y 52 -1 O VAL Y 51 N ILE Y 44 SHEET 1 AE9 7 ARG Y 61 VAL Y 66 0 SHEET 2 AE9 7 GLN Y 142 GLY Y 149 0 SHEET 3 AE9 7 PHE Y 237 ASN Y 251 -1 O LYS Y 241 N GLN Y 144 SHEET 4 AE9 7 TYR Y 280 SER Y 285 -1 O THR Y 283 N ARG Y 247 SHEET 5 AE9 7 GLN Y 317 ASP Y 324 -1 O PHE Y 319 N GLY Y 149 SHEET 6 AE9 7 TRP Y 435 ASN Y 438 1 O TRP Y 435 N VAL Y 62 SHEET 7 AE9 7 VAL b 289 SER b 290 -1 O VAL b 289 N MET Y 244 SHEET 1 AF1 2 VAL Y 107 LEU Y 113 0 SHEET 2 AF1 2 VAL Y 134 ASP Y 139 -1 O MET Y 138 N SER Y 108 SHEET 1 AF2 3 LEU Y 177 VAL Y 183 0 SHEET 2 AF2 3 LEU Y 154 LYS Y 160 -1 N GLY Y 155 O SER Y 182 SHEET 3 AF2 3 TYR Y 220 PRO Y 221 -1 O TYR Y 220 N GLU Y 156 SHEET 1 AF3 6 GLU Y 255 VAL Y 256 0 SHEET 2 AF3 6 THR b 21 GLY b 38 0 SHEET 3 AF3 6 GLN b 86 ARG b 99 0 SHEET 4 AF3 6 TYR b 300 TRP b 301 -1 O TYR b 300 N LEU b 95 SHEET 5 AF3 6 MET b 331 SER b 336 0 SHEET 6 AF3 6 TYR b 348 THR b 370 -1 O TYR b 351 N LEU b 333 SHEET 1 AF4 2 ILE b 44 LYS b 45 0 SHEET 2 AF4 2 THR b 50 VAL b 52 -1 O VAL b 51 N ILE b 44 SHEET 1 AF5 2 VAL b 107 LEU b 113 0 SHEET 2 AF5 2 VAL b 134 ASP b 139 -1 O MET b 138 N SER b 108 SHEET 1 AF6 4 LEU b 177 VAL b 183 0 SHEET 2 AF6 4 LEU b 154 LYS b 160 -1 N HIS b 157 O ILE b 180 SHEET 3 AF6 4 CYS b 218 PRO b 221 -1 O TYR b 220 N GLU b 156 SHEET 4 AF6 4 MET b 189 VAL b 190 1 N MET b 189 O LYS b 219 SHEET 1 AF7 6 GLU B 10 VAL B 12 0 SHEET 2 AF7 6 THR B 114 VAL B 118 1 O THR B 117 N VAL B 12 SHEET 3 AF7 6 ALA B 92 GLY B 99 -1 N TYR B 94 O THR B 114 SHEET 4 AF7 6 ALA B 33 ARG B 40 -1 N VAL B 37 O TYR B 95 SHEET 5 AF7 6 GLY B 44 ASP B 52 -1 O ILE B 51 N ILE B 34 SHEET 6 AF7 6 ASP B 57 TYR B 60 -1 O ASP B 57 N ASP B 52 SHEET 1 AF8 3 VAL B 18 LEU B 20 0 SHEET 2 AF8 3 TYR B 80 LEU B 83 -1 O LEU B 81 N LEU B 20 SHEET 3 AF8 3 ALA B 68 THR B 71 -1 N THR B 69 O GLN B 82 SHEET 1 AF9 4 SER B 127 LEU B 131 0 SHEET 2 AF9 4 VAL B 143 TYR B 152 -1 O LEU B 148 N TYR B 129 SHEET 3 AF9 4 LEU B 181 VAL B 190 -1 O VAL B 188 N LEU B 145 SHEET 4 AF9 4 VAL B 170 GLN B 178 -1 N GLN B 178 O LEU B 181 SHEET 1 AG1 3 THR B 158 THR B 160 0 SHEET 2 AG1 3 THR B 201 ALA B 205 -1 O ASN B 203 N THR B 160 SHEET 3 AG1 3 LYS B 212 LYS B 215 -1 O LYS B 212 N VAL B 204 SHEET 1 AG2 4 MET C 4 GLN C 6 0 SHEET 2 AG2 4 ARG C 18 ALA C 25 -1 O LYS C 24 N THR C 5 SHEET 3 AG2 4 ASP C 70 SER C 76 -1 O PHE C 71 N CYS C 23 SHEET 4 AG2 4 PHE C 62 SER C 67 -1 N THR C 63 O THR C 74 SHEET 1 AG3 2 PHE C 10 SER C 12 0 SHEET 2 AG3 2 LYS C 103 GLU C 105 1 O GLU C 105 N MET C 11 SHEET 1 AG4 5 ASN C 53 ARG C 54 0 SHEET 2 AG4 5 LYS C 45 TYR C 49 -1 N TYR C 49 O ASN C 53 SHEET 3 AG4 5 VAL C 33 GLN C 38 -1 N GLN C 37 O LYS C 45 SHEET 4 AG4 5 ASP C 85 GLN C 90 -1 O ASP C 85 N GLN C 38 SHEET 5 AG4 5 THR C 97 PHE C 98 -1 O THR C 97 N GLN C 90 SHEET 1 AG5 4 THR C 114 PHE C 118 0 SHEET 2 AG5 4 GLY C 129 PHE C 139 -1 O PHE C 135 N SER C 116 SHEET 3 AG5 4 TYR C 173 THR C 182 -1 O LEU C 181 N ALA C 130 SHEET 4 AG5 4 VAL C 159 ALA C 163 -1 N LEU C 160 O THR C 178 SHEET 1 AG6 4 SER C 153 GLU C 154 0 SHEET 2 AG6 4 ILE C 144 ILE C 150 -1 N ILE C 150 O SER C 153 SHEET 3 AG6 4 SER C 191 HIS C 198 -1 O THR C 193 N LYS C 149 SHEET 4 AG6 4 ILE C 205 ASN C 210 -1 O ILE C 205 N ALA C 196 SHEET 1 AG7 6 GLU E 10 VAL E 12 0 SHEET 2 AG7 6 THR E 114 VAL E 118 1 O THR E 117 N VAL E 12 SHEET 3 AG7 6 ALA E 92 GLY E 99 -1 N TYR E 94 O THR E 114 SHEET 4 AG7 6 ALA E 33 ARG E 40 -1 N HIS E 35 O ASN E 97 SHEET 5 AG7 6 GLY E 44 ASP E 52 -1 O ILE E 51 N ILE E 34 SHEET 6 AG7 6 ASP E 57 TYR E 60 -1 O GLU E 59 N ALA E 50 SHEET 1 AG8 3 VAL E 18 LEU E 20 0 SHEET 2 AG8 3 TYR E 80 LEU E 83 -1 O LEU E 81 N LEU E 20 SHEET 3 AG8 3 ALA E 68 THR E 71 -1 N THR E 69 O GLN E 82 SHEET 1 AG9 4 SER E 127 LEU E 131 0 SHEET 2 AG9 4 VAL E 143 TYR E 152 -1 O LEU E 148 N TYR E 129 SHEET 3 AG9 4 LEU E 181 VAL E 190 -1 O VAL E 188 N LEU E 145 SHEET 4 AG9 4 VAL E 170 GLN E 178 -1 N GLN E 178 O LEU E 181 SHEET 1 AH1 3 THR E 158 THR E 160 0 SHEET 2 AH1 3 VAL E 200 ALA E 205 -1 O ASN E 203 N THR E 160 SHEET 3 AH1 3 LYS E 212 LYS E 216 -1 O LYS E 212 N VAL E 204 SHEET 1 AH2 4 MET F 4 GLN F 6 0 SHEET 2 AH2 4 ARG F 18 ALA F 25 -1 O LYS F 24 N THR F 5 SHEET 3 AH2 4 ASP F 70 SER F 76 -1 O LEU F 73 N ILE F 21 SHEET 4 AH2 4 PHE F 62 SER F 67 -1 N THR F 63 O THR F 74 SHEET 1 AH3 2 PHE F 10 THR F 13 0 SHEET 2 AH3 2 LYS F 103 LEU F 106 1 O GLU F 105 N MET F 11 SHEET 1 AH4 5 ASN F 53 ARG F 54 0 SHEET 2 AH4 5 LYS F 45 TYR F 49 -1 N TYR F 49 O ASN F 53 SHEET 3 AH4 5 VAL F 33 GLN F 38 -1 N TRP F 35 O ILE F 48 SHEET 4 AH4 5 ASP F 85 GLN F 90 -1 O ASP F 85 N GLN F 38 SHEET 5 AH4 5 THR F 97 PHE F 98 -1 O THR F 97 N GLN F 90 SHEET 1 AH5 4 THR F 114 PHE F 118 0 SHEET 2 AH5 4 GLY F 129 PHE F 139 -1 O PHE F 135 N SER F 116 SHEET 3 AH5 4 TYR F 173 THR F 182 -1 O LEU F 179 N VAL F 132 SHEET 4 AH5 4 VAL F 159 ALA F 163 -1 N LEU F 160 O THR F 178 SHEET 1 AH6 4 SER F 153 GLU F 154 0 SHEET 2 AH6 4 ILE F 144 ILE F 150 -1 N ILE F 150 O SER F 153 SHEET 3 AH6 4 SER F 191 HIS F 198 -1 O GLU F 195 N LYS F 147 SHEET 4 AH6 4 ILE F 205 ASN F 210 -1 O LYS F 207 N CYS F 194 SHEET 1 AH7 7 GLU H 10 VAL H 12 0 SHEET 2 AH7 7 ALA H 33 ARG H 40 0 SHEET 3 AH7 7 GLY H 44 ILE H 51 -1 O GLU H 46 N LYS H 38 SHEET 4 AH7 7 THR H 58 TYR H 60 -1 O GLU H 59 N ALA H 50 SHEET 5 AH7 7 ALA H 92 GLY H 99 -1 O ASN H 97 N HIS H 35 SHEET 6 AH7 7 TYR H 109 TRP H 110 -1 O TYR H 109 N ALA H 98 SHEET 7 AH7 7 THR H 114 VAL H 118 -1 O VAL H 116 N ALA H 92 SHEET 1 AH8 3 VAL H 18 LEU H 20 0 SHEET 2 AH8 3 TYR H 80 LEU H 83 -1 O LEU H 81 N LEU H 20 SHEET 3 AH8 3 ALA H 68 THR H 71 -1 N THR H 69 O GLN H 82 SHEET 1 AH9 4 SER H 127 LEU H 131 0 SHEET 2 AH9 4 VAL H 143 TYR H 152 -1 O LEU H 148 N TYR H 129 SHEET 3 AH9 4 LEU H 181 VAL H 190 -1 O VAL H 190 N VAL H 143 SHEET 4 AH9 4 VAL H 170 GLN H 178 -1 N GLN H 178 O LEU H 181 SHEET 1 AI1 3 THR H 158 THR H 160 0 SHEET 2 AI1 3 THR H 201 ALA H 205 -1 O ASN H 203 N THR H 160 SHEET 3 AI1 3 LYS H 212 LYS H 215 -1 O LYS H 212 N VAL H 204 SHEET 1 AI2 4 MET I 4 GLN I 6 0 SHEET 2 AI2 4 ARG I 18 ALA I 25 -1 O LYS I 24 N THR I 5 SHEET 3 AI2 4 ASP I 70 SER I 76 -1 O LEU I 73 N ILE I 21 SHEET 4 AI2 4 PHE I 62 SER I 67 -1 N THR I 63 O THR I 74 SHEET 1 AI3 2 PHE I 10 THR I 13 0 SHEET 2 AI3 2 LYS I 103 LEU I 106 1 O GLU I 105 N MET I 11 SHEET 1 AI4 5 ASN I 53 ARG I 54 0 SHEET 2 AI4 5 LYS I 45 TYR I 49 -1 N TYR I 49 O ASN I 53 SHEET 3 AI4 5 VAL I 33 GLN I 38 -1 N GLN I 37 O LYS I 45 SHEET 4 AI4 5 ASP I 85 GLN I 90 -1 O ASP I 85 N GLN I 38 SHEET 5 AI4 5 THR I 97 PHE I 98 -1 O THR I 97 N GLN I 90 SHEET 1 AI5 4 THR I 114 PHE I 118 0 SHEET 2 AI5 4 GLY I 129 PHE I 139 -1 O PHE I 135 N SER I 116 SHEET 3 AI5 4 TYR I 173 THR I 182 -1 O LEU I 181 N ALA I 130 SHEET 4 AI5 4 VAL I 159 ALA I 163 -1 N LEU I 160 O THR I 178 SHEET 1 AI6 4 SER I 153 GLU I 154 0 SHEET 2 AI6 4 ILE I 144 ILE I 150 -1 N ILE I 150 O SER I 153 SHEET 3 AI6 4 SER I 191 HIS I 198 -1 O THR I 193 N LYS I 149 SHEET 4 AI6 4 ILE I 205 ASN I 210 -1 O LYS I 207 N CYS I 194 SHEET 1 AI7 6 GLU K 10 VAL K 12 0 SHEET 2 AI7 6 THR K 114 VAL K 118 1 O THR K 117 N VAL K 12 SHEET 3 AI7 6 ALA K 92 GLY K 99 -1 N ALA K 92 O VAL K 116 SHEET 4 AI7 6 ALA K 33 ARG K 40 -1 N HIS K 35 O ASN K 97 SHEET 5 AI7 6 GLY K 44 ASP K 52 -1 O ILE K 51 N ILE K 34 SHEET 6 AI7 6 ASP K 57 TYR K 60 -1 O GLU K 59 N ALA K 50 SHEET 1 AI8 3 VAL K 18 LEU K 20 0 SHEET 2 AI8 3 TYR K 80 LEU K 83 -1 O LEU K 81 N LEU K 20 SHEET 3 AI8 3 ALA K 68 THR K 71 -1 N THR K 69 O GLN K 82 SHEET 1 AI9 4 SER K 127 LEU K 131 0 SHEET 2 AI9 4 VAL K 143 TYR K 152 -1 O LEU K 148 N TYR K 129 SHEET 3 AI9 4 LEU K 181 VAL K 190 -1 O VAL K 188 N LEU K 145 SHEET 4 AI9 4 VAL K 170 GLN K 178 -1 N GLN K 178 O LEU K 181 SHEET 1 AJ1 3 THR K 158 THR K 160 0 SHEET 2 AJ1 3 THR K 201 ALA K 205 -1 O ASN K 203 N THR K 160 SHEET 3 AJ1 3 LYS K 212 LYS K 215 -1 O LYS K 212 N VAL K 204 SHEET 1 AJ2 4 MET L 4 GLN L 6 0 SHEET 2 AJ2 4 ARG L 18 ALA L 25 -1 O LYS L 24 N THR L 5 SHEET 3 AJ2 4 ASP L 70 SER L 76 -1 O LEU L 73 N ILE L 21 SHEET 4 AJ2 4 PHE L 62 SER L 67 -1 N THR L 63 O THR L 74 SHEET 1 AJ3 2 PHE L 10 THR L 13 0 SHEET 2 AJ3 2 LYS L 103 LEU L 106 1 O GLU L 105 N MET L 11 SHEET 1 AJ4 5 ASN L 53 ARG L 54 0 SHEET 2 AJ4 5 LYS L 45 TYR L 49 -1 N TYR L 49 O ASN L 53 SHEET 3 AJ4 5 VAL L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 4 AJ4 5 ASP L 85 GLN L 90 -1 O ASP L 85 N GLN L 38 SHEET 5 AJ4 5 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AJ5 4 THR L 114 PHE L 118 0 SHEET 2 AJ5 4 GLY L 129 PHE L 139 -1 O PHE L 135 N SER L 116 SHEET 3 AJ5 4 TYR L 173 THR L 182 -1 O LEU L 181 N ALA L 130 SHEET 4 AJ5 4 VAL L 159 ALA L 163 -1 N LEU L 160 O THR L 178 SHEET 1 AJ6 4 SER L 153 GLU L 154 0 SHEET 2 AJ6 4 ILE L 144 ILE L 150 -1 N ILE L 150 O SER L 153 SHEET 3 AJ6 4 SER L 191 HIS L 198 -1 O THR L 193 N LYS L 149 SHEET 4 AJ6 4 ILE L 205 ASN L 210 -1 O LYS L 207 N CYS L 194 SHEET 1 AJ7 7 GLU N 10 VAL N 12 0 SHEET 2 AJ7 7 ILE N 34 ARG N 40 0 SHEET 3 AJ7 7 GLY N 44 ASP N 52 -1 O GLU N 46 N LYS N 38 SHEET 4 AJ7 7 ASP N 57 TYR N 60 -1 O ASP N 57 N ASP N 52 SHEET 5 AJ7 7 ALA N 92 ALA N 98 -1 O ASN N 97 N HIS N 35 SHEET 6 AJ7 7 TYR N 109 TRP N 110 -1 O TYR N 109 N ALA N 98 SHEET 7 AJ7 7 THR N 114 VAL N 118 -1 O THR N 114 N TYR N 94 SHEET 1 AJ8 3 VAL N 18 LEU N 20 0 SHEET 2 AJ8 3 TYR N 80 LEU N 83 -1 O LEU N 81 N LEU N 20 SHEET 3 AJ8 3 ALA N 68 THR N 71 -1 N THR N 69 O GLN N 82 SHEET 1 AJ9 4 SER N 127 LEU N 131 0 SHEET 2 AJ9 4 VAL N 143 TYR N 152 -1 O LEU N 148 N TYR N 129 SHEET 3 AJ9 4 LEU N 181 VAL N 190 -1 O VAL N 188 N LEU N 145 SHEET 4 AJ9 4 VAL N 170 GLN N 178 -1 N GLN N 178 O LEU N 181 SHEET 1 AK1 3 THR N 158 THR N 160 0 SHEET 2 AK1 3 THR N 201 ALA N 205 -1 O ASN N 203 N THR N 160 SHEET 3 AK1 3 LYS N 212 LYS N 215 -1 O LYS N 212 N VAL N 204 SHEET 1 AK2 4 MET O 4 GLN O 6 0 SHEET 2 AK2 4 ARG O 18 ALA O 25 -1 O LYS O 24 N THR O 5 SHEET 3 AK2 4 ASP O 70 SER O 76 -1 O LEU O 73 N ILE O 21 SHEET 4 AK2 4 PHE O 62 SER O 67 -1 N THR O 63 O THR O 74 SHEET 1 AK3 2 PHE O 10 THR O 13 0 SHEET 2 AK3 2 LYS O 103 LEU O 106 1 O GLU O 105 N MET O 11 SHEET 1 AK4 5 ASN O 53 ARG O 54 0 SHEET 2 AK4 5 LYS O 45 TYR O 49 -1 N TYR O 49 O ASN O 53 SHEET 3 AK4 5 VAL O 33 GLN O 38 -1 N TRP O 35 O ILE O 48 SHEET 4 AK4 5 ASP O 85 GLN O 90 -1 O ASP O 85 N GLN O 38 SHEET 5 AK4 5 THR O 97 PHE O 98 -1 O THR O 97 N GLN O 90 SHEET 1 AK5 4 THR O 114 PHE O 118 0 SHEET 2 AK5 4 GLY O 129 PHE O 139 -1 O PHE O 135 N SER O 116 SHEET 3 AK5 4 TYR O 173 THR O 182 -1 O LEU O 181 N ALA O 130 SHEET 4 AK5 4 VAL O 159 ALA O 163 -1 N LEU O 160 O THR O 178 SHEET 1 AK6 4 SER O 153 GLU O 154 0 SHEET 2 AK6 4 ILE O 144 ILE O 150 -1 N ILE O 150 O SER O 153 SHEET 3 AK6 4 SER O 191 HIS O 198 -1 O GLU O 195 N LYS O 147 SHEET 4 AK6 4 ILE O 205 ASN O 210 -1 O ILE O 205 N ALA O 196 SHEET 1 AK7 6 GLU g 10 VAL g 12 0 SHEET 2 AK7 6 THR g 114 VAL g 118 1 O THR g 117 N VAL g 12 SHEET 3 AK7 6 ALA g 92 GLY g 99 -1 N ALA g 92 O VAL g 116 SHEET 4 AK7 6 ALA g 33 ARG g 40 -1 N HIS g 35 O ASN g 97 SHEET 5 AK7 6 GLY g 44 ASP g 52 -1 O GLU g 46 N LYS g 38 SHEET 6 AK7 6 ASP g 57 TYR g 60 -1 O GLU g 59 N ALA g 50 SHEET 1 AK8 3 VAL g 18 LEU g 20 0 SHEET 2 AK8 3 TYR g 80 LEU g 83 -1 O LEU g 81 N LEU g 20 SHEET 3 AK8 3 ALA g 68 THR g 71 -1 N THR g 69 O GLN g 82 SHEET 1 AK9 4 SER g 127 LEU g 131 0 SHEET 2 AK9 4 VAL g 143 TYR g 152 -1 O LEU g 148 N TYR g 129 SHEET 3 AK9 4 LEU g 181 VAL g 190 -1 O VAL g 188 N LEU g 145 SHEET 4 AK9 4 VAL g 170 GLN g 178 -1 N GLN g 178 O LEU g 181 SHEET 1 AL1 3 THR g 158 THR g 160 0 SHEET 2 AL1 3 THR g 201 ALA g 205 -1 O ASN g 203 N THR g 160 SHEET 3 AL1 3 LYS g 212 LYS g 215 -1 O LYS g 212 N VAL g 204 SHEET 1 AL2 4 MET j 4 GLN j 6 0 SHEET 2 AL2 4 VAL j 19 ALA j 25 -1 O LYS j 24 N THR j 5 SHEET 3 AL2 4 ASP j 70 ILE j 75 -1 O PHE j 71 N CYS j 23 SHEET 4 AL2 4 PHE j 62 SER j 67 -1 N THR j 63 O THR j 74 SHEET 1 AL3 2 PHE j 10 THR j 13 0 SHEET 2 AL3 2 LYS j 103 LEU j 106 1 O GLU j 105 N MET j 11 SHEET 1 AL4 5 ASN j 53 ARG j 54 0 SHEET 2 AL4 5 LYS j 45 TYR j 49 -1 N TYR j 49 O ASN j 53 SHEET 3 AL4 5 VAL j 33 GLN j 38 -1 N TRP j 35 O ILE j 48 SHEET 4 AL4 5 ASP j 85 GLN j 90 -1 O ASP j 85 N GLN j 38 SHEET 5 AL4 5 THR j 97 PHE j 98 -1 O THR j 97 N GLN j 90 SHEET 1 AL5 4 THR j 114 PHE j 118 0 SHEET 2 AL5 4 GLY j 129 PHE j 139 -1 O PHE j 135 N SER j 116 SHEET 3 AL5 4 TYR j 173 THR j 182 -1 O LEU j 181 N ALA j 130 SHEET 4 AL5 4 VAL j 159 ALA j 163 -1 N LEU j 160 O THR j 178 SHEET 1 AL6 4 SER j 153 GLU j 154 0 SHEET 2 AL6 4 ILE j 144 ILE j 150 -1 N ILE j 150 O SER j 153 SHEET 3 AL6 4 SER j 191 HIS j 198 -1 O THR j 193 N LYS j 149 SHEET 4 AL6 4 ILE j 205 ASN j 210 -1 O ILE j 205 N ALA j 196 SHEET 1 AL7 6 GLU Q 10 VAL Q 12 0 SHEET 2 AL7 6 THR Q 114 VAL Q 118 1 O THR Q 117 N GLU Q 10 SHEET 3 AL7 6 ALA Q 92 GLY Q 99 -1 N ALA Q 92 O VAL Q 116 SHEET 4 AL7 6 ALA Q 33 ARG Q 40 -1 N HIS Q 35 O ASN Q 97 SHEET 5 AL7 6 GLY Q 44 ASP Q 52 -1 O GLU Q 46 N LYS Q 38 SHEET 6 AL7 6 ASP Q 57 TYR Q 60 -1 O ASP Q 57 N ASP Q 52 SHEET 1 AL8 3 VAL Q 18 LEU Q 20 0 SHEET 2 AL8 3 TYR Q 80 LEU Q 83 -1 O LEU Q 81 N LEU Q 20 SHEET 3 AL8 3 ALA Q 68 THR Q 71 -1 N THR Q 69 O GLN Q 82 SHEET 1 AL9 4 SER Q 127 LEU Q 131 0 SHEET 2 AL9 4 VAL Q 143 TYR Q 152 -1 O LEU Q 148 N TYR Q 129 SHEET 3 AL9 4 LEU Q 181 VAL Q 190 -1 O VAL Q 190 N VAL Q 143 SHEET 4 AL9 4 VAL Q 170 GLN Q 178 -1 N GLN Q 178 O LEU Q 181 SHEET 1 AM1 3 THR Q 158 THR Q 160 0 SHEET 2 AM1 3 THR Q 201 ALA Q 205 -1 O ASN Q 203 N THR Q 160 SHEET 3 AM1 3 LYS Q 212 LYS Q 215 -1 O LYS Q 212 N VAL Q 204 SHEET 1 AM2 4 MET R 4 GLN R 6 0 SHEET 2 AM2 4 ARG R 18 ALA R 25 -1 O LYS R 24 N THR R 5 SHEET 3 AM2 4 ASP R 70 SER R 76 -1 O PHE R 71 N CYS R 23 SHEET 4 AM2 4 PHE R 62 SER R 67 -1 N THR R 63 O THR R 74 SHEET 1 AM3 2 PHE R 10 THR R 13 0 SHEET 2 AM3 2 LYS R 103 LEU R 106 1 O GLU R 105 N MET R 11 SHEET 1 AM4 5 ASN R 53 ARG R 54 0 SHEET 2 AM4 5 LYS R 45 TYR R 49 -1 N TYR R 49 O ASN R 53 SHEET 3 AM4 5 VAL R 33 GLN R 38 -1 N TRP R 35 O ILE R 48 SHEET 4 AM4 5 ASP R 85 GLN R 90 -1 O ASP R 85 N GLN R 38 SHEET 5 AM4 5 THR R 97 PHE R 98 -1 O THR R 97 N GLN R 90 SHEET 1 AM5 4 THR R 114 PHE R 118 0 SHEET 2 AM5 4 GLY R 129 PHE R 139 -1 O PHE R 135 N SER R 116 SHEET 3 AM5 4 TYR R 173 THR R 182 -1 O LEU R 181 N ALA R 130 SHEET 4 AM5 4 VAL R 159 ALA R 163 -1 N LEU R 160 O THR R 178 SHEET 1 AM6 4 SER R 153 GLU R 154 0 SHEET 2 AM6 4 ILE R 144 ILE R 150 -1 N ILE R 150 O SER R 153 SHEET 3 AM6 4 SER R 191 HIS R 198 -1 O THR R 193 N LYS R 149 SHEET 4 AM6 4 ILE R 205 ASN R 210 -1 O ILE R 205 N ALA R 196 SHEET 1 AM7 6 GLU T 10 VAL T 12 0 SHEET 2 AM7 6 THR T 114 VAL T 118 1 O THR T 117 N VAL T 12 SHEET 3 AM7 6 ALA T 92 GLY T 99 -1 N ALA T 92 O VAL T 116 SHEET 4 AM7 6 ALA T 33 ARG T 40 -1 N HIS T 35 O ASN T 97 SHEET 5 AM7 6 GLY T 44 ASP T 52 -1 O GLU T 46 N LYS T 38 SHEET 6 AM7 6 ASP T 57 TYR T 60 -1 O ASP T 57 N ASP T 52 SHEET 1 AM8 3 VAL T 18 LEU T 20 0 SHEET 2 AM8 3 TYR T 80 LEU T 83 -1 O LEU T 81 N LEU T 20 SHEET 3 AM8 3 ALA T 68 THR T 71 -1 N THR T 69 O GLN T 82 SHEET 1 AM9 4 SER T 127 LEU T 131 0 SHEET 2 AM9 4 VAL T 143 TYR T 152 -1 O LEU T 148 N TYR T 129 SHEET 3 AM9 4 LEU T 181 VAL T 190 -1 O VAL T 190 N VAL T 143 SHEET 4 AM9 4 VAL T 170 GLN T 178 -1 N GLN T 178 O LEU T 181 SHEET 1 AN1 3 THR T 158 THR T 160 0 SHEET 2 AN1 3 THR T 201 ALA T 205 -1 O ASN T 203 N THR T 160 SHEET 3 AN1 3 LYS T 212 LYS T 215 -1 O LYS T 212 N VAL T 204 SHEET 1 AN2 4 MET U 4 GLN U 6 0 SHEET 2 AN2 4 ARG U 18 ALA U 25 -1 O LYS U 24 N THR U 5 SHEET 3 AN2 4 ASP U 70 SER U 76 -1 O LEU U 73 N ILE U 21 SHEET 4 AN2 4 PHE U 62 SER U 67 -1 N THR U 63 O THR U 74 SHEET 1 AN3 2 PHE U 10 THR U 13 0 SHEET 2 AN3 2 LYS U 103 LEU U 106 1 O GLU U 105 N MET U 11 SHEET 1 AN4 5 ASN U 53 ARG U 54 0 SHEET 2 AN4 5 LYS U 45 TYR U 49 -1 N TYR U 49 O ASN U 53 SHEET 3 AN4 5 VAL U 33 GLN U 38 -1 N GLN U 37 O LYS U 45 SHEET 4 AN4 5 ASP U 85 GLN U 90 -1 O ASP U 85 N GLN U 38 SHEET 5 AN4 5 THR U 97 PHE U 98 -1 O THR U 97 N GLN U 90 SHEET 1 AN5 4 VAL U 115 PHE U 118 0 SHEET 2 AN5 4 GLY U 129 PHE U 139 -1 O PHE U 135 N SER U 116 SHEET 3 AN5 4 TYR U 173 THR U 182 -1 O LEU U 181 N ALA U 130 SHEET 4 AN5 4 VAL U 159 ALA U 163 -1 N LEU U 160 O THR U 178 SHEET 1 AN6 4 SER U 153 GLU U 154 0 SHEET 2 AN6 4 ILE U 144 ILE U 150 -1 N ILE U 150 O SER U 153 SHEET 3 AN6 4 SER U 191 HIS U 198 -1 O GLU U 195 N LYS U 147 SHEET 4 AN6 4 ILE U 205 ASN U 210 -1 O ILE U 205 N ALA U 196 SHEET 1 AN7 7 GLU W 10 VAL W 12 0 SHEET 2 AN7 7 ALA W 33 ARG W 40 0 SHEET 3 AN7 7 GLY W 44 ASP W 52 -1 O GLU W 46 N LYS W 38 SHEET 4 AN7 7 ASP W 57 TYR W 60 -1 O ASP W 57 N ASP W 52 SHEET 5 AN7 7 ALA W 92 GLY W 99 -1 O ASN W 97 N HIS W 35 SHEET 6 AN7 7 TYR W 109 TRP W 110 -1 O TYR W 109 N ALA W 98 SHEET 7 AN7 7 THR W 114 VAL W 118 -1 O THR W 114 N TYR W 94 SHEET 1 AN8 3 VAL W 18 LEU W 20 0 SHEET 2 AN8 3 TYR W 80 LEU W 83 -1 O LEU W 81 N LEU W 20 SHEET 3 AN8 3 ALA W 68 THR W 71 -1 N THR W 69 O GLN W 82 SHEET 1 AN9 4 SER W 127 LEU W 131 0 SHEET 2 AN9 4 VAL W 143 TYR W 152 -1 O LEU W 148 N TYR W 129 SHEET 3 AN9 4 LEU W 181 VAL W 190 -1 O VAL W 188 N LEU W 145 SHEET 4 AN9 4 VAL W 170 GLN W 178 -1 N GLN W 178 O LEU W 181 SHEET 1 AO1 3 THR W 158 THR W 160 0 SHEET 2 AO1 3 THR W 201 ALA W 205 -1 O ASN W 203 N THR W 160 SHEET 3 AO1 3 LYS W 212 LYS W 215 -1 O LYS W 212 N VAL W 204 SHEET 1 AO2 4 MET X 4 GLN X 6 0 SHEET 2 AO2 4 VAL X 19 ALA X 25 -1 O LYS X 24 N THR X 5 SHEET 3 AO2 4 ASP X 70 ILE X 75 -1 O PHE X 71 N CYS X 23 SHEET 4 AO2 4 PHE X 62 SER X 67 -1 N THR X 63 O THR X 74 SHEET 1 AO3 2 PHE X 10 THR X 13 0 SHEET 2 AO3 2 LYS X 103 LEU X 106 1 O GLU X 105 N MET X 11 SHEET 1 AO4 5 ASN X 53 ARG X 54 0 SHEET 2 AO4 5 LYS X 45 TYR X 49 -1 N TYR X 49 O ASN X 53 SHEET 3 AO4 5 VAL X 33 GLN X 38 -1 N GLN X 37 O LYS X 45 SHEET 4 AO4 5 ASP X 85 GLN X 90 -1 O ASP X 85 N GLN X 38 SHEET 5 AO4 5 THR X 97 PHE X 98 -1 O THR X 97 N GLN X 90 SHEET 1 AO5 4 THR X 114 PHE X 118 0 SHEET 2 AO5 4 GLY X 129 PHE X 139 -1 O PHE X 135 N SER X 116 SHEET 3 AO5 4 TYR X 173 THR X 182 -1 O LEU X 179 N VAL X 132 SHEET 4 AO5 4 VAL X 159 ALA X 163 -1 N LEU X 160 O THR X 178 SHEET 1 AO6 4 SER X 153 GLU X 154 0 SHEET 2 AO6 4 ILE X 144 ILE X 150 -1 N ILE X 150 O SER X 153 SHEET 3 AO6 4 SER X 191 HIS X 198 -1 O THR X 193 N LYS X 149 SHEET 4 AO6 4 ILE X 205 ASN X 210 -1 O ILE X 205 N ALA X 196 SHEET 1 AO7 6 GLU Z 10 VAL Z 12 0 SHEET 2 AO7 6 THR Z 114 VAL Z 118 1 O THR Z 117 N VAL Z 12 SHEET 3 AO7 6 ALA Z 92 GLY Z 99 -1 N ALA Z 92 O VAL Z 116 SHEET 4 AO7 6 ALA Z 33 ARG Z 40 -1 N HIS Z 35 O ASN Z 97 SHEET 5 AO7 6 GLY Z 44 ASP Z 52 -1 O GLU Z 46 N LYS Z 38 SHEET 6 AO7 6 ASP Z 57 TYR Z 60 -1 O ASP Z 57 N ASP Z 52 SHEET 1 AO8 3 VAL Z 18 LEU Z 20 0 SHEET 2 AO8 3 TYR Z 80 LEU Z 83 -1 O LEU Z 81 N LEU Z 20 SHEET 3 AO8 3 ALA Z 68 THR Z 71 -1 N THR Z 69 O GLN Z 82 SHEET 1 AO9 4 SER Z 127 LEU Z 131 0 SHEET 2 AO9 4 VAL Z 143 TYR Z 152 -1 O LEU Z 148 N TYR Z 129 SHEET 3 AO9 4 LEU Z 181 VAL Z 190 -1 O VAL Z 188 N LEU Z 145 SHEET 4 AO9 4 VAL Z 170 GLN Z 178 -1 N GLN Z 178 O LEU Z 181 SHEET 1 AP1 3 THR Z 158 THR Z 160 0 SHEET 2 AP1 3 THR Z 201 ALA Z 205 -1 O ASN Z 203 N THR Z 160 SHEET 3 AP1 3 LYS Z 212 LYS Z 215 -1 O ASP Z 214 N CYS Z 202 SHEET 1 AP2 4 MET a 4 GLN a 6 0 SHEET 2 AP2 4 ARG a 18 ALA a 25 -1 O LYS a 24 N THR a 5 SHEET 3 AP2 4 ASP a 70 SER a 76 -1 O LEU a 73 N ILE a 21 SHEET 4 AP2 4 PHE a 62 SER a 67 -1 N THR a 63 O THR a 74 SHEET 1 AP3 2 PHE a 10 THR a 13 0 SHEET 2 AP3 2 LYS a 103 LEU a 106 1 O GLU a 105 N MET a 11 SHEET 1 AP4 5 ASN a 53 ARG a 54 0 SHEET 2 AP4 5 LYS a 45 TYR a 49 -1 N TYR a 49 O ASN a 53 SHEET 3 AP4 5 VAL a 33 GLN a 38 -1 N GLN a 37 O LYS a 45 SHEET 4 AP4 5 ASP a 85 GLN a 90 -1 O ASP a 85 N GLN a 38 SHEET 5 AP4 5 THR a 97 PHE a 98 -1 O THR a 97 N GLN a 90 SHEET 1 AP5 4 THR a 114 PHE a 118 0 SHEET 2 AP5 4 GLY a 129 PHE a 139 -1 O PHE a 135 N SER a 116 SHEET 3 AP5 4 TYR a 173 THR a 182 -1 O LEU a 181 N ALA a 130 SHEET 4 AP5 4 VAL a 159 ALA a 163 -1 N LEU a 160 O THR a 178 SHEET 1 AP6 4 SER a 153 GLU a 154 0 SHEET 2 AP6 4 ILE a 144 ILE a 150 -1 N ILE a 150 O SER a 153 SHEET 3 AP6 4 SER a 191 HIS a 198 -1 O THR a 193 N LYS a 149 SHEET 4 AP6 4 ILE a 205 ASN a 210 -1 O ILE a 205 N ALA a 196 SSBOND 1 CYS B 22 CYS B 96 1555 1555 2.04 SSBOND 2 CYS B 147 CYS B 202 1555 1555 2.03 SSBOND 3 CYS C 23 CYS C 88 1555 1555 2.03 SSBOND 4 CYS C 134 CYS C 194 1555 1555 2.03 SSBOND 5 CYS E 22 CYS E 96 1555 1555 2.03 SSBOND 6 CYS E 147 CYS E 202 1555 1555 2.03 SSBOND 7 CYS F 23 CYS F 88 1555 1555 2.03 SSBOND 8 CYS F 134 CYS F 194 1555 1555 2.03 SSBOND 9 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 10 CYS H 147 CYS H 202 1555 1555 2.03 SSBOND 11 CYS I 23 CYS I 88 1555 1555 2.03 SSBOND 12 CYS I 134 CYS I 194 1555 1555 2.03 SSBOND 13 CYS K 22 CYS K 96 1555 1555 2.03 SSBOND 14 CYS K 147 CYS K 202 1555 1555 2.03 SSBOND 15 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 16 CYS L 134 CYS L 194 1555 1555 2.03 SSBOND 17 CYS N 22 CYS N 96 1555 1555 2.03 SSBOND 18 CYS N 147 CYS N 202 1555 1555 2.03 SSBOND 19 CYS O 23 CYS O 88 1555 1555 2.03 SSBOND 20 CYS O 134 CYS O 194 1555 1555 2.03 SSBOND 21 CYS g 22 CYS g 96 1555 1555 2.03 SSBOND 22 CYS g 147 CYS g 202 1555 1555 2.03 SSBOND 23 CYS j 23 CYS j 88 1555 1555 2.03 SSBOND 24 CYS j 134 CYS j 194 1555 1555 2.03 SSBOND 25 CYS Q 22 CYS Q 96 1555 1555 2.04 SSBOND 26 CYS Q 147 CYS Q 202 1555 1555 2.03 SSBOND 27 CYS R 23 CYS R 88 1555 1555 2.03 SSBOND 28 CYS R 134 CYS R 194 1555 1555 2.03 SSBOND 29 CYS T 22 CYS T 96 1555 1555 2.03 SSBOND 30 CYS T 147 CYS T 202 1555 1555 2.03 SSBOND 31 CYS U 23 CYS U 88 1555 1555 2.03 SSBOND 32 CYS U 134 CYS U 194 1555 1555 2.03 SSBOND 33 CYS W 22 CYS W 96 1555 1555 2.04 SSBOND 34 CYS W 147 CYS W 202 1555 1555 2.03 SSBOND 35 CYS X 23 CYS X 88 1555 1555 2.03 SSBOND 36 CYS X 134 CYS X 194 1555 1555 2.03 SSBOND 37 CYS Z 22 CYS Z 96 1555 1555 2.04 SSBOND 38 CYS Z 147 CYS Z 202 1555 1555 2.03 SSBOND 39 CYS a 23 CYS a 88 1555 1555 2.03 SSBOND 40 CYS a 134 CYS a 194 1555 1555 2.03 CISPEP 1 ARG A 46 ALA A 47 0 -6.19 CISPEP 2 GLY A 123 SER A 124 0 -1.56 CISPEP 3 GLN A 163 CYS A 164 0 -2.79 CISPEP 4 THR A 167 PRO A 168 0 -10.30 CISPEP 5 GLN A 170 ALA A 171 0 1.34 CISPEP 6 GLY A 268 SER A 269 0 -1.56 CISPEP 7 ARG D 46 ALA D 47 0 -6.17 CISPEP 8 GLY D 123 SER D 124 0 -1.74 CISPEP 9 GLN D 163 CYS D 164 0 -2.93 CISPEP 10 THR D 167 PRO D 168 0 -10.26 CISPEP 11 GLN D 170 ALA D 171 0 1.76 CISPEP 12 GLY D 268 SER D 269 0 -1.35 CISPEP 13 ARG G 46 ALA G 47 0 -6.03 CISPEP 14 GLY G 123 SER G 124 0 -1.32 CISPEP 15 GLN G 163 CYS G 164 0 -2.50 CISPEP 16 THR G 167 PRO G 168 0 -10.29 CISPEP 17 GLN G 170 ALA G 171 0 1.54 CISPEP 18 GLY G 268 SER G 269 0 -0.98 CISPEP 19 ARG J 46 ALA J 47 0 -5.86 CISPEP 20 GLY J 123 SER J 124 0 -1.57 CISPEP 21 GLN J 163 CYS J 164 0 -2.79 CISPEP 22 THR J 167 PRO J 168 0 -11.16 CISPEP 23 GLN J 170 ALA J 171 0 1.73 CISPEP 24 GLY J 268 SER J 269 0 -2.23 CISPEP 25 ARG M 46 ALA M 47 0 -6.31 CISPEP 26 GLY M 123 SER M 124 0 -1.67 CISPEP 27 GLN M 163 CYS M 164 0 -2.72 CISPEP 28 THR M 167 PRO M 168 0 -10.42 CISPEP 29 GLN M 170 ALA M 171 0 1.43 CISPEP 30 GLY M 268 SER M 269 0 -1.63 CISPEP 31 ARG P 46 ALA P 47 0 -6.84 CISPEP 32 GLY P 123 SER P 124 0 -1.60 CISPEP 33 GLN P 163 CYS P 164 0 -2.59 CISPEP 34 THR P 167 PRO P 168 0 -11.28 CISPEP 35 GLN P 170 ALA P 171 0 1.60 CISPEP 36 GLY P 268 SER P 269 0 -3.80 CISPEP 37 ARG S 46 ALA S 47 0 -6.79 CISPEP 38 GLY S 123 SER S 124 0 -1.71 CISPEP 39 GLN S 163 CYS S 164 0 -2.26 CISPEP 40 THR S 167 PRO S 168 0 -10.32 CISPEP 41 GLN S 170 ALA S 171 0 1.71 CISPEP 42 GLY S 268 SER S 269 0 -1.68 CISPEP 43 ARG V 46 ALA V 47 0 -6.47 CISPEP 44 GLY V 123 SER V 124 0 -1.54 CISPEP 45 GLN V 163 CYS V 164 0 -3.07 CISPEP 46 THR V 167 PRO V 168 0 -10.21 CISPEP 47 GLN V 170 ALA V 171 0 1.61 CISPEP 48 GLY V 268 SER V 269 0 -0.84 CISPEP 49 ARG Y 46 ALA Y 47 0 -6.43 CISPEP 50 GLY Y 123 SER Y 124 0 -1.48 CISPEP 51 GLN Y 163 CYS Y 164 0 -2.37 CISPEP 52 THR Y 167 PRO Y 168 0 -10.37 CISPEP 53 GLN Y 170 ALA Y 171 0 1.68 CISPEP 54 GLY Y 268 SER Y 269 0 -4.70 CISPEP 55 ARG b 46 ALA b 47 0 -6.27 CISPEP 56 GLY b 123 SER b 124 0 -1.49 CISPEP 57 GLN b 163 CYS b 164 0 -2.91 CISPEP 58 THR b 167 PRO b 168 0 -10.14 CISPEP 59 GLN b 170 ALA b 171 0 1.58 CISPEP 60 GLY b 268 SER b 269 0 -0.73 CISPEP 61 ALA B 121 LYS B 122 0 -1.04 CISPEP 62 ASN B 140 SER B 141 0 1.60 CISPEP 63 PHE B 153 PRO B 154 0 -1.97 CISPEP 64 GLU B 155 PRO B 156 0 -2.05 CISPEP 65 TRP B 195 PRO B 196 0 -0.26 CISPEP 66 TYR C 94 PRO C 95 0 -1.16 CISPEP 67 TYR C 140 PRO C 141 0 2.87 CISPEP 68 LYS E 30 ASP E 31 0 -9.82 CISPEP 69 ARG E 106 PHE E 107 0 29.92 CISPEP 70 PHE E 107 PRO E 108 0 -0.43 CISPEP 71 ASN E 140 SER E 141 0 1.76 CISPEP 72 PHE E 153 PRO E 154 0 -1.82 CISPEP 73 GLU E 155 PRO E 156 0 -2.28 CISPEP 74 TRP E 195 PRO E 196 0 0.12 CISPEP 75 TYR F 94 PRO F 95 0 -1.21 CISPEP 76 ALA F 109 ASP F 110 0 -13.16 CISPEP 77 TYR F 140 PRO F 141 0 3.21 CISPEP 78 LYS H 30 ASP H 31 0 -9.66 CISPEP 79 ASN H 140 SER H 141 0 3.42 CISPEP 80 PHE H 153 PRO H 154 0 -2.34 CISPEP 81 GLU H 155 PRO H 156 0 -1.99 CISPEP 82 TRP H 195 PRO H 196 0 0.28 CISPEP 83 TYR I 94 PRO I 95 0 -1.38 CISPEP 84 TYR I 140 PRO I 141 0 2.85 CISPEP 85 SER K 76 ASN K 77 0 -1.18 CISPEP 86 ASN K 140 SER K 141 0 2.32 CISPEP 87 PHE K 153 PRO K 154 0 -1.91 CISPEP 88 GLU K 155 PRO K 156 0 -1.77 CISPEP 89 TRP K 195 PRO K 196 0 -0.16 CISPEP 90 TYR L 94 PRO L 95 0 -1.44 CISPEP 91 TYR L 140 PRO L 141 0 2.83 CISPEP 92 LYS N 30 ASP N 31 0 23.04 CISPEP 93 GLY N 105 ARG N 106 0 -0.38 CISPEP 94 ASN N 140 SER N 141 0 1.77 CISPEP 95 PHE N 153 PRO N 154 0 -2.04 CISPEP 96 GLU N 155 PRO N 156 0 -1.89 CISPEP 97 TRP N 195 PRO N 196 0 -0.44 CISPEP 98 TYR O 94 PRO O 95 0 -1.49 CISPEP 99 TYR O 140 PRO O 141 0 2.22 CISPEP 100 LYS g 30 ASP g 31 0 14.30 CISPEP 101 ASN g 140 SER g 141 0 3.58 CISPEP 102 PHE g 153 PRO g 154 0 -2.04 CISPEP 103 GLU g 155 PRO g 156 0 -1.66 CISPEP 104 TRP g 195 PRO g 196 0 -0.16 CISPEP 105 TYR j 94 PRO j 95 0 -1.01 CISPEP 106 ALA j 109 ASP j 110 0 13.82 CISPEP 107 TYR j 140 PRO j 141 0 2.72 CISPEP 108 SER Q 76 ASN Q 77 0 3.61 CISPEP 109 THR Q 78 ALA Q 79 0 4.08 CISPEP 110 ALA Q 120 ALA Q 121 0 -3.33 CISPEP 111 ASN Q 140 SER Q 141 0 2.05 CISPEP 112 PHE Q 153 PRO Q 154 0 -1.99 CISPEP 113 GLU Q 155 PRO Q 156 0 -1.60 CISPEP 114 TRP Q 195 PRO Q 196 0 -0.27 CISPEP 115 TYR R 94 PRO R 95 0 -1.37 CISPEP 116 TYR R 140 PRO R 141 0 2.97 CISPEP 117 ASN T 28 ILE T 29 0 10.11 CISPEP 118 LYS T 30 ASP T 31 0 7.57 CISPEP 119 ASN T 140 SER T 141 0 1.88 CISPEP 120 PHE T 153 PRO T 154 0 -1.74 CISPEP 121 GLU T 155 PRO T 156 0 -2.04 CISPEP 122 TRP T 195 PRO T 196 0 -0.22 CISPEP 123 TYR U 94 PRO U 95 0 -1.53 CISPEP 124 TYR U 140 PRO U 141 0 3.21 CISPEP 125 LYS W 30 ASP W 31 0 -2.17 CISPEP 126 SER W 76 ASN W 77 0 22.68 CISPEP 127 ASN W 140 SER W 141 0 1.89 CISPEP 128 PHE W 153 PRO W 154 0 -2.08 CISPEP 129 GLU W 155 PRO W 156 0 -1.86 CISPEP 130 TRP W 195 PRO W 196 0 -0.13 CISPEP 131 TYR X 94 PRO X 95 0 -1.01 CISPEP 132 TYR X 140 PRO X 141 0 2.97 CISPEP 133 ASN Z 140 SER Z 141 0 -1.62 CISPEP 134 PHE Z 153 PRO Z 154 0 -1.62 CISPEP 135 GLU Z 155 PRO Z 156 0 -2.35 CISPEP 136 TRP Z 195 PRO Z 196 0 -0.26 CISPEP 137 TYR a 94 PRO a 95 0 -1.18 CISPEP 138 ALA a 109 ASP a 110 0 -10.82 CISPEP 139 TYR a 140 PRO a 141 0 3.47 CRYST1 139.090 208.309 205.948 90.00 95.61 90.00 P 1 21 1 20 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.007190 0.000000 0.000707 0.00000 SCALE2 0.000000 0.004801 0.000000 0.00000 SCALE3 0.000000 0.000000 0.004879 0.00000