HEADER VIRAL PROTEIN 29-JUL-21 7PA7 TITLE BK POLYOMAVIRUS VP1 IN COMPLEX WITH SCFV 29B1 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SCFV 29B1 ANTIBODY HEAVY CHAIN; COMPND 3 CHAIN: eee, aaa, bbb, ccc, ddd, mmm, nnn, ooo, ppp, qqq; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: MAJOR CAPSID PROTEIN VP1; COMPND 7 CHAIN: AAA, BBB, CCC, DDD, EEE, MMM, NNN, OOO, PPP, QQQ; COMPND 8 SYNONYM: MAJOR STRUCTURAL PROTEIN VP1; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 511693; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: BETAPOLYOMAVIRUS HOMINIS; SOURCE 9 ORGANISM_TAXID: 1891762; SOURCE 10 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 511693 KEYWDS ANTIBODY, POLYOMAVIRUS, VP1, NEUTRALIZATION, VIRAL PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR C.HARPRECHT,L.J.STROEH,J.FREYTAG,T.STEHLE JRNL AUTH C.HARPRECHT,L.J.STROEH,L.SENN,B.A.O'HARA,F.NAGEL,J.FREYTAG, JRNL AUTH 2 Y.D.STIEHROF,W.J.ATWOOD,B.COMBALUZIER,T.STEHLE JRNL TITL STRUCTURAL CHARACTERIZATION OF HUMAN NEUTRALIZING ANTIBODIES JRNL TITL 2 AGAINST JC AND BK POLYOMAVIRUS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.60 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0258 REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, REMARK 3 : NICHOLLS,WINN,LONG,VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : NULL REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 48.44 REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 91.9 REMARK 3 NUMBER OF REFLECTIONS : 180984 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : FREE R-VALUE REMARK 3 FREE R VALUE TEST SET SELECTION : NULL REMARK 3 R VALUE (WORKING + TEST SET) : NULL REMARK 3 R VALUE (WORKING SET) : 0.247 REMARK 3 FREE R VALUE : 0.272 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 1.000 REMARK 3 FREE R VALUE TEST SET COUNT : 1810 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.60 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.67 REMARK 3 REFLECTION IN BIN (WORKING SET) : 13779 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 95.53 REMARK 3 BIN R VALUE (WORKING SET) : 0.3620 REMARK 3 BIN FREE R VALUE SET COUNT : 139 REMARK 3 BIN FREE R VALUE : 0.3890 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 36977 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 0 REMARK 3 SOLVENT ATOMS : 726 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : 34.00 REMARK 3 MEAN B VALUE (OVERALL, A**2) : 26.75 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : -1.10300 REMARK 3 B22 (A**2) : -1.28800 REMARK 3 B33 (A**2) : 1.89800 REMARK 3 B12 (A**2) : -0.18300 REMARK 3 B13 (A**2) : 0.49100 REMARK 3 B23 (A**2) : 0.28700 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): 0.764 REMARK 3 ESU BASED ON FREE R VALUE (A): 0.335 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): NULL REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.898 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.870 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 37873 ; 0.007 ; 0.013 REMARK 3 BOND LENGTHS OTHERS (A): 33398 ; 0.037 ; 0.017 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 51569 ; 1.438 ; 1.648 REMARK 3 BOND ANGLES OTHERS (DEGREES): 77534 ; 2.376 ; 1.572 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 4822 ; 6.792 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 1878 ;33.569 ;22.199 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 5716 ;16.608 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 227 ;21.388 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 4923 ; 0.064 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 43139 ; 0.005 ; 0.020 REMARK 3 GENERAL PLANES OTHERS (A): 8014 ; 0.007 ; 0.020 REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): 6089 ; 0.209 ; 0.200 REMARK 3 NON-BONDED CONTACTS OTHERS (A): 115 ; 0.285 ; 0.200 REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): 17731 ; 0.166 ; 0.200 REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): 862 ; 0.209 ; 0.200 REMARK 3 H-BOND (X...Y) OTHERS (A): 2 ; 0.044 ; 0.200 REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 19418 ; 2.639 ; 2.874 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 19417 ; 2.639 ; 2.874 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 24195 ; 4.158 ; 4.292 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): 24196 ; 4.158 ; 4.292 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 18455 ; 2.848 ; 2.939 REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): 18455 ; 2.848 ; 2.939 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 27374 ; 4.507 ; 4.348 REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): 27375 ; 4.507 ; 4.348 REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK BULK SOLVENT REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THEIR REMARK 3 RIDING POSITIONS REMARK 4 REMARK 4 7PA7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE. REMARK 100 THE DEPOSITION ID IS D_1292115635. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 13-OCT-17 REMARK 200 TEMPERATURE (KELVIN) : 93 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SLS REMARK 200 BEAMLINE : X06DA REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.99 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS 2M-F REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : XDS REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 181005 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.600 REMARK 200 RESOLUTION RANGE LOW (A) : 49.200 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 94.8 REMARK 200 DATA REDUNDANCY : 1.800 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 5.9000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.81 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 1.400 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: 4MJ1, 4KQ3 REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 59.65 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.05 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M SODIUM MALONATE (PH 5.5), 14.4% REMARK 280 PEG 3350, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1, 2 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: eee, AAA, BBB, CCC, DDD, EEE, REMARK 350 AND CHAINS: aaa, bbb, ccc, ddd REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 2 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: MMM, NNN, OOO, PPP, QQQ, mmm, REMARK 350 AND CHAINS: nnn, ooo, ppp, qqq REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER e 115A REMARK 465 GLY e 115B REMARK 465 SER e 115C REMARK 465 GLY e 115D REMARK 465 LYS e 115E REMARK 465 PRO e 115F REMARK 465 GLY e 115G REMARK 465 SER e 115H REMARK 465 GLY e 115I REMARK 465 GLU e 115J REMARK 465 GLY e 115K REMARK 465 SER e 115L REMARK 465 THR e 115M REMARK 465 LYS e 115N REMARK 465 GLY e 115O REMARK 465 SER e 247 REMARK 465 SER e 248 REMARK 465 GLY A 27 REMARK 465 SER A 28 REMARK 465 HIS A 29 REMARK 465 MET A 30 REMARK 465 GLY A 31 REMARK 465 GLY A 32 REMARK 465 VAL A 33 REMARK 465 GLU A 34 REMARK 465 THR A 40 REMARK 465 GLY A 41 REMARK 465 VAL A 42 REMARK 465 ASP A 43 REMARK 465 ALA A 44 REMARK 465 GLU A 101 REMARK 465 ASP A 102 REMARK 465 LEU A 103 REMARK 465 THR A 104 REMARK 465 CYS A 105 REMARK 465 GLY A 106 REMARK 465 LYS A 297 REMARK 465 ASN A 298 REMARK 465 PRO A 299 REMARK 465 TYR A 300 REMARK 465 PRO A 301 REMARK 465 GLY B 27 REMARK 465 SER B 28 REMARK 465 HIS B 29 REMARK 465 MET B 30 REMARK 465 GLY B 31 REMARK 465 GLY B 32 REMARK 465 VAL B 33 REMARK 465 THR B 40 REMARK 465 GLY B 41 REMARK 465 VAL B 42 REMARK 465 ASP B 43 REMARK 465 ALA B 44 REMARK 465 GLU B 101 REMARK 465 ASP B 102 REMARK 465 LEU B 103 REMARK 465 THR B 104 REMARK 465 CYS B 105 REMARK 465 GLY B 106 REMARK 465 PRO B 299 REMARK 465 TYR B 300 REMARK 465 PRO B 301 REMARK 465 GLY C 27 REMARK 465 SER C 28 REMARK 465 HIS C 29 REMARK 465 MET C 30 REMARK 465 GLY C 31 REMARK 465 GLY C 32 REMARK 465 VAL C 33 REMARK 465 THR C 40 REMARK 465 GLY C 41 REMARK 465 VAL C 42 REMARK 465 ASP C 43 REMARK 465 ASN C 100 REMARK 465 GLU C 101 REMARK 465 ASP C 102 REMARK 465 LEU C 103 REMARK 465 THR C 104 REMARK 465 CYS C 105 REMARK 465 GLY C 106 REMARK 465 ASN C 107 REMARK 465 PRO C 299 REMARK 465 TYR C 300 REMARK 465 PRO C 301 REMARK 465 GLY D 27 REMARK 465 SER D 28 REMARK 465 HIS D 29 REMARK 465 MET D 30 REMARK 465 GLY D 31 REMARK 465 GLY D 32 REMARK 465 VAL D 33 REMARK 465 GLU D 34 REMARK 465 VAL D 35 REMARK 465 LEU D 36 REMARK 465 GLU D 37 REMARK 465 VAL D 38 REMARK 465 LYS D 39 REMARK 465 THR D 40 REMARK 465 GLY D 41 REMARK 465 VAL D 42 REMARK 465 ASP D 43 REMARK 465 GLU D 101 REMARK 465 ASP D 102 REMARK 465 LEU D 103 REMARK 465 THR D 104 REMARK 465 CYS D 105 REMARK 465 GLY D 106 REMARK 465 ASN D 298 REMARK 465 PRO D 299 REMARK 465 TYR D 300 REMARK 465 PRO D 301 REMARK 465 GLY E 27 REMARK 465 SER E 28 REMARK 465 HIS E 29 REMARK 465 MET E 30 REMARK 465 GLY E 31 REMARK 465 GLY E 32 REMARK 465 PRO E 301 REMARK 465 GLY M 27 REMARK 465 SER M 28 REMARK 465 HIS M 29 REMARK 465 MET M 30 REMARK 465 GLY M 31 REMARK 465 GLY M 32 REMARK 465 VAL M 38 REMARK 465 LYS M 39 REMARK 465 THR M 40 REMARK 465 GLY M 41 REMARK 465 VAL M 42 REMARK 465 ASP M 43 REMARK 465 ASN M 100 REMARK 465 GLU M 101 REMARK 465 ASP M 102 REMARK 465 LEU M 103 REMARK 465 THR M 104 REMARK 465 CYS M 105 REMARK 465 GLY M 106 REMARK 465 ASN M 298 REMARK 465 PRO M 299 REMARK 465 TYR M 300 REMARK 465 PRO M 301 REMARK 465 GLY N 27 REMARK 465 SER N 28 REMARK 465 HIS N 29 REMARK 465 MET N 30 REMARK 465 GLY N 31 REMARK 465 GLY N 32 REMARK 465 VAL N 33 REMARK 465 GLU N 37 REMARK 465 VAL N 38 REMARK 465 LYS N 39 REMARK 465 THR N 40 REMARK 465 GLY N 41 REMARK 465 VAL N 42 REMARK 465 ASP N 43 REMARK 465 GLU N 101 REMARK 465 ASP N 102 REMARK 465 LEU N 103 REMARK 465 THR N 104 REMARK 465 CYS N 105 REMARK 465 GLY N 106 REMARK 465 LYS N 297 REMARK 465 ASN N 298 REMARK 465 PRO N 299 REMARK 465 TYR N 300 REMARK 465 PRO N 301 REMARK 465 GLY O 27 REMARK 465 SER O 28 REMARK 465 HIS O 29 REMARK 465 MET O 30 REMARK 465 GLY O 31 REMARK 465 GLY O 32 REMARK 465 GLY P 27 REMARK 465 SER P 28 REMARK 465 HIS P 29 REMARK 465 MET P 30 REMARK 465 GLY P 31 REMARK 465 GLY P 32 REMARK 465 VAL P 33 REMARK 465 GLU P 34 REMARK 465 VAL P 35 REMARK 465 THR P 40 REMARK 465 GLY P 41 REMARK 465 VAL P 42 REMARK 465 ASP P 43 REMARK 465 GLU P 101 REMARK 465 ASP P 102 REMARK 465 LEU P 103 REMARK 465 THR P 104 REMARK 465 CYS P 105 REMARK 465 GLY P 106 REMARK 465 ASN P 107 REMARK 465 LYS P 297 REMARK 465 ASN P 298 REMARK 465 PRO P 299 REMARK 465 TYR P 300 REMARK 465 PRO P 301 REMARK 465 GLY Q 27 REMARK 465 SER Q 28 REMARK 465 HIS Q 29 REMARK 465 MET Q 30 REMARK 465 GLY Q 31 REMARK 465 GLY Q 32 REMARK 465 LYS Q 39 REMARK 465 THR Q 40 REMARK 465 GLY Q 41 REMARK 465 VAL Q 42 REMARK 465 ASP Q 43 REMARK 465 ALA Q 44 REMARK 465 GLU Q 101 REMARK 465 ASP Q 102 REMARK 465 LEU Q 103 REMARK 465 THR Q 104 REMARK 465 CYS Q 105 REMARK 465 ASN Q 298 REMARK 465 PRO Q 299 REMARK 465 TYR Q 300 REMARK 465 PRO Q 301 REMARK 465 LEU a 111A REMARK 465 GLY a 111B REMARK 465 SER a 111C REMARK 465 THR a 111D REMARK 465 SER a 111E REMARK 465 GLY a 111F REMARK 465 SER a 111G REMARK 465 GLY a 111H REMARK 465 LYS a 111I REMARK 465 PRO a 111J REMARK 465 GLY a 111K REMARK 465 SER a 111L REMARK 465 GLY a 111M REMARK 465 GLU a 111N REMARK 465 GLY a 111O REMARK 465 SER a 111P REMARK 465 THR a 111Q REMARK 465 LYS a 111R REMARK 465 GLY a 111S REMARK 465 SER a 247 REMARK 465 SER a 248 REMARK 465 GLY b 3 REMARK 465 SER b 4 REMARK 465 SER b 113A REMARK 465 THR b 113B REMARK 465 SER b 113C REMARK 465 GLY b 113D REMARK 465 SER b 113E REMARK 465 GLY b 113F REMARK 465 LYS b 113G REMARK 465 PRO b 113H REMARK 465 GLY b 113I REMARK 465 SER b 113J REMARK 465 GLY b 113K REMARK 465 GLU b 113L REMARK 465 GLY b 113M REMARK 465 SER b 113N REMARK 465 THR b 113O REMARK 465 LYS b 113P REMARK 465 GLY b 113Q REMARK 465 SER b 247 REMARK 465 SER b 248 REMARK 465 GLY c 3 REMARK 465 SER c 4 REMARK 465 LEU c 111A REMARK 465 GLY c 111B REMARK 465 SER c 111C REMARK 465 THR c 111D REMARK 465 SER c 111E REMARK 465 GLY c 111F REMARK 465 SER c 111G REMARK 465 GLY c 111H REMARK 465 LYS c 111I REMARK 465 PRO c 111J REMARK 465 GLY c 111K REMARK 465 SER c 111L REMARK 465 GLY c 111M REMARK 465 GLU c 111N REMARK 465 GLY c 111O REMARK 465 SER c 111P REMARK 465 THR c 111Q REMARK 465 LYS c 111R REMARK 465 GLY c 111S REMARK 465 VAL c 246 REMARK 465 SER c 247 REMARK 465 SER c 248 REMARK 465 THR d 114A REMARK 465 SER d 114B REMARK 465 GLY d 114C REMARK 465 SER d 114D REMARK 465 GLY d 114E REMARK 465 LYS d 114F REMARK 465 PRO d 114G REMARK 465 GLY d 114H REMARK 465 SER d 114I REMARK 465 GLY d 114J REMARK 465 GLU d 114K REMARK 465 GLY d 114L REMARK 465 SER d 114M REMARK 465 THR d 114N REMARK 465 LYS d 114O REMARK 465 GLY d 114P REMARK 465 SER d 247 REMARK 465 SER d 248 REMARK 465 GLY m 112A REMARK 465 SER m 112B REMARK 465 THR m 112C REMARK 465 SER m 112D REMARK 465 GLY m 112E REMARK 465 SER m 112F REMARK 465 GLY m 112G REMARK 465 LYS m 112H REMARK 465 PRO m 112I REMARK 465 GLY m 112J REMARK 465 SER m 112K REMARK 465 GLY m 112L REMARK 465 GLU m 112M REMARK 465 GLY m 112N REMARK 465 SER m 112O REMARK 465 THR m 112P REMARK 465 LYS m 112Q REMARK 465 GLY m 112R REMARK 465 VAL m 246 REMARK 465 SER m 247 REMARK 465 SER m 248 REMARK 465 GLY n 112A REMARK 465 SER n 112B REMARK 465 THR n 112C REMARK 465 SER n 112D REMARK 465 GLY n 112E REMARK 465 SER n 112F REMARK 465 GLY n 112G REMARK 465 LYS n 112H REMARK 465 PRO n 112I REMARK 465 GLY n 112J REMARK 465 SER n 112K REMARK 465 GLY n 112L REMARK 465 GLU n 112M REMARK 465 GLY n 112N REMARK 465 SER n 112O REMARK 465 THR n 112P REMARK 465 LYS n 112Q REMARK 465 GLY n 112R REMARK 465 SER n 247 REMARK 465 SER n 248 REMARK 465 GLY o 112A REMARK 465 SER o 112B REMARK 465 THR o 112C REMARK 465 SER o 112D REMARK 465 GLY o 112E REMARK 465 SER o 112F REMARK 465 GLY o 112G REMARK 465 LYS o 112H REMARK 465 PRO o 112I REMARK 465 GLY o 112J REMARK 465 SER o 112K REMARK 465 GLY o 112L REMARK 465 GLU o 112M REMARK 465 GLY o 112N REMARK 465 SER o 112O REMARK 465 THR o 112P REMARK 465 LYS o 112Q REMARK 465 SER o 247 REMARK 465 SER o 248 REMARK 465 GLY p 3 REMARK 465 GLY p 112A REMARK 465 SER p 112B REMARK 465 THR p 112C REMARK 465 SER p 112D REMARK 465 GLY p 112E REMARK 465 SER p 112F REMARK 465 GLY p 112G REMARK 465 LYS p 112H REMARK 465 PRO p 112I REMARK 465 GLY p 112J REMARK 465 SER p 112K REMARK 465 GLY p 112L REMARK 465 GLU p 112M REMARK 465 GLY p 112N REMARK 465 SER p 112O REMARK 465 THR p 112P REMARK 465 LYS p 112Q REMARK 465 GLY p 112R REMARK 465 SER p 247 REMARK 465 SER p 248 REMARK 465 GLY q 3 REMARK 465 GLY q 112A REMARK 465 SER q 112B REMARK 465 THR q 112C REMARK 465 SER q 112D REMARK 465 GLY q 112E REMARK 465 SER q 112F REMARK 465 GLY q 112G REMARK 465 LYS q 112H REMARK 465 PRO q 112I REMARK 465 GLY q 112J REMARK 465 SER q 112K REMARK 465 GLY q 112L REMARK 465 GLU q 112M REMARK 465 GLY q 112N REMARK 465 SER q 112O REMARK 465 THR q 112P REMARK 465 LYS q 112Q REMARK 465 GLY q 112R REMARK 465 SER q 248 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLU e 62 CG CD OE1 OE2 REMARK 470 ARG e 96 CG CD NE CZ NH1 NH2 REMARK 470 LYS e 189 CE NZ REMARK 470 GLN e 240 CG CD OE1 NE2 REMARK 470 LEU A 36 CG CD1 CD2 REMARK 470 GLU A 37 CG CD OE1 OE2 REMARK 470 LYS A 39 CG CD CE NZ REMARK 470 ASN A 107 CG OD1 ND2 REMARK 470 VAL A 296 CG1 CG2 REMARK 470 LEU B 36 CG CD1 CD2 REMARK 470 GLU B 37 CG CD OE1 OE2 REMARK 470 LYS B 39 CE NZ REMARK 470 GLU B 248 CG CD OE1 OE2 REMARK 470 ARG B 290 CD NE CZ NH1 NH2 REMARK 470 LYS B 297 CE NZ REMARK 470 GLU C 34 CG CD OE1 OE2 REMARK 470 GLU C 37 CG CD OE1 OE2 REMARK 470 LYS C 39 CE NZ REMARK 470 ASN C 98 CG OD1 ND2 REMARK 470 LYS C 297 CE NZ REMARK 470 LYS D 84 CE NZ REMARK 470 ASN D 98 CB CG OD1 ND2 REMARK 470 LEU D 99 CG CD1 CD2 REMARK 470 LEU D 108 CG CD1 CD2 REMARK 470 LYS D 135 CG CD CE NZ REMARK 470 GLU D 138 CG CD OE1 OE2 REMARK 470 GLU D 248 CG CD OE1 OE2 REMARK 470 VAL E 33 CG1 CG2 REMARK 470 GLU E 37 CG CD OE1 OE2 REMARK 470 LYS E 39 CG CD CE NZ REMARK 470 GLU E 138 CG CD OE1 OE2 REMARK 470 GLU E 217 CG CD OE1 OE2 REMARK 470 GLU E 248 CG CD OE1 OE2 REMARK 470 LYS E 256 CG CD CE NZ REMARK 470 VAL M 33 CG1 CG2 REMARK 470 GLU M 34 CG CD OE1 OE2 REMARK 470 GLU M 37 CG CD OE1 OE2 REMARK 470 ASN M 98 CG OD1 ND2 REMARK 470 LEU M 109 CG CD1 CD2 REMARK 470 LYS M 172 CG CD CE NZ REMARK 470 GLN M 186 CG CD OE1 NE2 REMARK 470 GLU M 248 CG CD OE1 OE2 REMARK 470 LYS M 293 CG CD CE NZ REMARK 470 LYS M 297 CG CD CE NZ REMARK 470 VAL N 35 CG1 CG2 REMARK 470 LEU N 108 CG CD1 CD2 REMARK 470 GLU N 138 CG CD OE1 OE2 REMARK 470 GLU N 217 CG CD OE1 OE2 REMARK 470 GLU N 248 CG CD OE1 OE2 REMARK 470 LYS N 256 CG CD CE NZ REMARK 470 VAL O 33 CG1 CG2 REMARK 470 LYS O 39 CG CD CE NZ REMARK 470 ASN O 182 CG OD1 ND2 REMARK 470 GLU O 248 CG CD OE1 OE2 REMARK 470 LYS O 256 CG CD CE NZ REMARK 470 LEU P 36 CG CD1 CD2 REMARK 470 GLU P 37 CG CD OE1 OE2 REMARK 470 LYS P 39 CE NZ REMARK 470 GLU P 248 CG CD OE1 OE2 REMARK 470 GLU Q 34 CG CD OE1 OE2 REMARK 470 LEU Q 36 CG CD1 CD2 REMARK 470 GLU Q 37 CG CD OE1 OE2 REMARK 470 LYS Q 69 CG CD CE NZ REMARK 470 GLU Q 248 CG CD OE1 OE2 REMARK 470 LYS Q 297 CG CD CE NZ REMARK 470 GLU a 62 CG CD OE1 OE2 REMARK 470 GLU a 125 CG CD OE1 OE2 REMARK 470 LYS a 137 CG CD CE NZ REMARK 470 ASP a 180 CG OD1 OD2 REMARK 470 GLU b 62 CG CD OE1 OE2 REMARK 470 GLU b 85 CG CD OE1 OE2 REMARK 470 ARG b 96 CG CD NE CZ NH1 NH2 REMARK 470 HIS b 99 CG ND1 CD2 CE1 NE2 REMARK 470 ARG b 108 CG CD NE CZ NH1 NH2 REMARK 470 LYS b 137 CG CD CE NZ REMARK 470 LYS b 189 CG CD CE NZ REMARK 470 GLN b 240 CG CD OE1 NE2 REMARK 470 VAL c 13 CG1 CG2 REMARK 470 LYS c 19 CG CD CE NZ REMARK 470 ARG c 22 CG CD NE CZ NH1 NH2 REMARK 470 ILE c 23 CG1 CG2 CD1 REMARK 470 GLU c 62 CG CD OE1 OE2 REMARK 470 THR c 72 CB OG1 CG2 REMARK 470 ARG c 79 CG CD NE CZ NH1 NH2 REMARK 470 GLU c 85 CG CD OE1 OE2 REMARK 470 ARG c 96 CG CD NE CZ NH1 NH2 REMARK 470 ARG c 108 CG CD NE CZ NH1 NH2 REMARK 470 GLU c 125 CG CD OE1 OE2 REMARK 470 GLN c 127 CG CD OE1 NE2 REMARK 470 LYS c 137 CG CD CE NZ REMARK 470 LYS c 167 CG CD CE NZ REMARK 470 LYS c 189 CG CD CE NZ REMARK 470 ARG c 191 CG CD NE CZ NH1 NH2 REMARK 470 PHE c 192 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LYS c 200 CG CD CE NZ REMARK 470 MET c 207 CG SD CE REMARK 470 ARG c 211 CG CD NE CZ NH1 NH2 REMARK 470 GLU c 213 CG CD OE1 OE2 REMARK 470 THR c 242 OG1 CG2 REMARK 470 LYS d 19 CG CD CE NZ REMARK 470 GLU d 62 CG CD OE1 OE2 REMARK 470 ARG d 96 CG CD NE CZ NH1 NH2 REMARK 470 GLU d 213 CG CD OE1 OE2 REMARK 470 ARG m 96 CG CD NE CZ NH1 NH2 REMARK 470 ARG m 108 CG CD NE CZ NH1 NH2 REMARK 470 GLU m 125 CG CD OE1 OE2 REMARK 470 LYS m 137 CG CD CE NZ REMARK 470 LEU m 144 CG CD1 CD2 REMARK 470 LYS m 167 CG CD CE NZ REMARK 470 LYS m 189 CG CD CE NZ REMARK 470 ARG m 191 CG CD NE CZ NH1 NH2 REMARK 470 PHE m 192 CG CD1 CD2 CE1 CE2 CZ REMARK 470 GLU m 213 CG CD OE1 OE2 REMARK 470 LYS n 19 CG CD CE NZ REMARK 470 GLU n 62 CG CD OE1 OE2 REMARK 470 ARG n 96 CG CD NE CZ NH1 NH2 REMARK 470 ASP n 98 CG OD1 OD2 REMARK 470 LYS n 137 CG CD CE NZ REMARK 470 ARG n 143 CG CD NE CZ NH1 NH2 REMARK 470 LYS n 167 CG CD CE NZ REMARK 470 ARG n 178 CG CD NE CZ NH1 NH2 REMARK 470 GLU o 62 CG CD OE1 OE2 REMARK 470 ARG o 96 CG CD NE CZ NH1 NH2 REMARK 470 GLU o 125 CG CD OE1 OE2 REMARK 470 VAL o 136 CG1 CG2 REMARK 470 LYS o 137 CG CD CE NZ REMARK 470 GLU p 62 CG CD OE1 OE2 REMARK 470 ARG p 108 CG CD NE CZ NH1 NH2 REMARK 470 LEU p 135 CG CD1 CD2 REMARK 470 LYS p 137 CG CD CE NZ REMARK 470 LYS p 167 CG CD CE NZ REMARK 470 SER p 209 OG REMARK 470 ARG p 211 CG CD NE CZ NH1 NH2 REMARK 470 LYS q 19 CG CD CE NZ REMARK 470 ASN q 29 CG OD1 ND2 REMARK 470 TYR q 69 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 ARG q 79 CG CD NE CZ NH1 NH2 REMARK 470 GLU q 85 CG CD OE1 OE2 REMARK 470 ARG q 96 CG CD NE CZ NH1 NH2 REMARK 470 HIS q 99 CG ND1 CD2 CE1 NE2 REMARK 470 GLU q 125 CG CD OE1 OE2 REMARK 470 LYS q 137 CG CD CE NZ REMARK 470 ARG q 178 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 CA GLYmm 3 O HOHmm 303 2.03 REMARK 500 CB LEUMM 109 O HOHMM 429 2.12 REMARK 500 CG2 THRcc 110 O HOHcc 325 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 OD1 ASNOO 107 NH2 ARGcc 178 1445 2.19 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SERee 4 131.03 -170.93 REMARK 500 ASPee 53 -43.64 76.18 REMARK 500 ALAee 86 -179.41 -173.42 REMARK 500 LEUAA 36 -151.01 -106.55 REMARK 500 VALAA 189 -128.12 -127.11 REMARK 500 LEUAA 198 99.25 -65.92 REMARK 500 ALAAA 203 -44.80 -141.73 REMARK 500 ARGAA 215 -145.03 -133.62 REMARK 500 LEUBB 36 -147.59 -107.70 REMARK 500 HISBB 139 -1.08 72.03 REMARK 500 VALBB 189 -137.31 -123.29 REMARK 500 ALABB 203 -42.83 -136.54 REMARK 500 ARGBB 215 -145.08 -139.40 REMARK 500 LEUCC 36 -150.16 -101.82 REMARK 500 VALCC 189 -137.18 -124.26 REMARK 500 ALACC 203 -42.42 -137.28 REMARK 500 ARGCC 215 -146.44 -138.34 REMARK 500 ASPCC 258 55.17 39.30 REMARK 500 VALDD 189 -140.42 -123.13 REMARK 500 ALADD 203 -43.46 -135.75 REMARK 500 ARGDD 215 -146.55 -138.77 REMARK 500 LEUEE 36 -150.83 -101.55 REMARK 500 HISEE 139 -3.82 75.64 REMARK 500 VALEE 189 -138.00 -123.56 REMARK 500 ARGEE 215 -147.46 -138.41 REMARK 500 THREE 238 143.64 -171.27 REMARK 500 LYSEE 256 4.65 -68.01 REMARK 500 ALAEE 257 -153.75 -153.93 REMARK 500 ASPEE 258 33.83 -94.68 REMARK 500 VALMM 189 -137.14 -123.56 REMARK 500 ALAMM 203 -42.60 -137.06 REMARK 500 ARGMM 215 -146.35 -139.34 REMARK 500 VALNN 189 -140.23 -121.41 REMARK 500 ALANN 203 -43.51 -136.56 REMARK 500 ARGNN 215 -147.95 -139.77 REMARK 500 LEUOO 36 -153.68 -99.51 REMARK 500 ASPOO 43 -2.97 75.36 REMARK 500 VALOO 189 -138.80 -122.94 REMARK 500 ALAOO 203 -41.76 -135.98 REMARK 500 ARGOO 215 -146.32 -137.02 REMARK 500 ASPOO 258 49.58 39.10 REMARK 500 VALPP 189 -137.92 -123.67 REMARK 500 ALAPP 203 -43.09 -136.20 REMARK 500 ARGPP 215 -146.42 -138.22 REMARK 500 GLUQQ 37 -152.60 49.88 REMARK 500 HISQQ 139 -0.39 71.31 REMARK 500 VALQQ 189 -137.43 -123.98 REMARK 500 ALAQQ 203 -44.00 -136.73 REMARK 500 ARGQQ 215 -145.30 -139.56 REMARK 500 ASNaa 28 107.90 -56.07 REMARK 500 REMARK 500 THIS ENTRY HAS 84 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 525 REMARK 525 SOLVENT REMARK 525 REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER; REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE REMARK 525 NUMBER; I=INSERTION CODE): REMARK 525 REMARK 525 M RES CSSEQI REMARK 525 HOH N 458 DISTANCE = 6.17 ANGSTROMS DBREF 7PA7ee 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7AA 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7BB 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7CC 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7DD 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7EE 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7MM 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7NN 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7OO 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7PP 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7QQ 31 301 UNP P03088 VP1_POVBK 31 301 DBREF 7PA7aa 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7bb 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7cc 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7dd 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7mm 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7nn 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7oo 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7pp 3 248 PDB 7PA7 7PA7 3 248 DBREF 7PA7qq 3 248 PDB 7PA7 7PA7 3 248 SEQADV 7PA7 GLYAA 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERAA 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISAA 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METAA 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPAA 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRAA 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRAA 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYBB 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERBB 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISBB 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METBB 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPBB 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRBB 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRBB 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYCC 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERCC 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISCC 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METCC 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPCC 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRCC 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRCC 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYDD 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERDD 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISDD 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METDD 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPDD 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRDD 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRDD 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYEE 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SEREE 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISEE 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METEE 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPEE 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THREE 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THREE 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYMM 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERMM 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISMM 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METMM 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPMM 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRMM 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRMM 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYNN 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERNN 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISNN 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METNN 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPNN 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRNN 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRNN 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYOO 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SEROO 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISOO 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METOO 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPOO 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THROO 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THROO 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYPP 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERPP 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISPP 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METPP 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPPP 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRPP 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRPP 219 UNP P03088 ALA 219 VARIANT SEQADV 7PA7 GLYQQ 27 UNP P03088 EXPRESSION TAG SEQADV 7PA7 SERQQ 28 UNP P03088 EXPRESSION TAG SEQADV 7PA7 HISQQ 29 UNP P03088 EXPRESSION TAG SEQADV 7PA7 METQQ 30 UNP P03088 EXPRESSION TAG SEQADV 7PA7 ASPQQ 158 UNP P03088 GLU 158 VARIANT SEQADV 7PA7 THRQQ 171 UNP P03088 SER 171 VARIANT SEQADV 7PA7 THRQQ 219 UNP P03088 ALA 219 VARIANT SEQRES 1ee 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2ee 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3ee 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4ee 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5ee 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6ee 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7ee 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8ee 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9ee 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10ee 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11ee 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12ee 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13ee 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14ee 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15ee 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16ee 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17ee 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18ee 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19ee 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20ee 252 VAL THR VAL SER SER SEQRES 1AA 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2AA 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3AA 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4AA 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5AA 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6AA 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7AA 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8AA 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9AA 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10AA 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11AA 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12AA 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13AA 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14AA 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15AA 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16AA 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17AA 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18AA 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19AA 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20AA 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21AA 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22AA 275 TYR PRO SEQRES 1BB 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2BB 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3BB 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4BB 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5BB 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6BB 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7BB 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8BB 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9BB 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10BB 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11BB 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12BB 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13BB 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14BB 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15BB 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16BB 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17BB 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18BB 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19BB 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20BB 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21BB 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22BB 275 TYR PRO SEQRES 1CC 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2CC 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3CC 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4CC 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5CC 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6CC 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7CC 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8CC 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9CC 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10CC 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11CC 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12CC 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13CC 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14CC 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15CC 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16CC 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17CC 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18CC 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19CC 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20CC 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21CC 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22CC 275 TYR PRO SEQRES 1DD 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2DD 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3DD 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4DD 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5DD 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6DD 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7DD 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8DD 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9DD 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10DD 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11DD 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12DD 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13DD 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14DD 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15DD 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16DD 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17DD 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18DD 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19DD 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20DD 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21DD 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22DD 275 TYR PRO SEQRES 1EE 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2EE 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3EE 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4EE 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5EE 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6EE 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7EE 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8EE 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9EE 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10EE 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11EE 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12EE 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13EE 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14EE 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15EE 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16EE 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17EE 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18EE 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19EE 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20EE 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21EE 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22EE 275 TYR PRO SEQRES 1MM 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2MM 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3MM 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4MM 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5MM 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6MM 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7MM 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8MM 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9MM 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10MM 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11MM 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12MM 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13MM 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14MM 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15MM 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16MM 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17MM 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18MM 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19MM 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20MM 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21MM 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22MM 275 TYR PRO SEQRES 1NN 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2NN 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3NN 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4NN 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5NN 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6NN 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7NN 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8NN 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9NN 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10NN 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11NN 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12NN 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13NN 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14NN 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15NN 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16NN 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17NN 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18NN 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19NN 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20NN 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21NN 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22NN 275 TYR PRO SEQRES 1OO 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2OO 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3OO 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4OO 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5OO 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6OO 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7OO 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8OO 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9OO 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10OO 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11OO 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12OO 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13OO 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14OO 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15OO 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16OO 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17OO 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18OO 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19OO 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20OO 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21OO 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22OO 275 TYR PRO SEQRES 1PP 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2PP 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3PP 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4PP 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5PP 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6PP 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7PP 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8PP 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9PP 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10PP 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11PP 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12PP 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13PP 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14PP 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15PP 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16PP 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17PP 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18PP 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19PP 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20PP 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21PP 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22PP 275 TYR PRO SEQRES 1QQ 275 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2QQ 275 THR GLY VAL ASP ALA ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3QQ 275 ASN PRO GLU MET GLY ASP PRO ASP GLU ASN LEU ARG GLY SEQRES 4QQ 275 PHE SER LEU LYS LEU SER ALA GLU ASN ASP PHE SER SER SEQRES 5QQ 275 ASP SER PRO GLU ARG LYS MET LEU PRO CYS TYR SER THR SEQRES 6QQ 275 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7QQ 275 CYS GLY ASN LEU LEU MET TRP GLU ALA VAL THR VAL GLN SEQRES 8QQ 275 THR GLU VAL ILE GLY ILE THR SER MET LEU ASN LEU HIS SEQRES 9QQ 275 ALA GLY SER GLN LYS VAL HIS GLU HIS GLY GLY GLY LYS SEQRES 10QQ 275 PRO ILE GLN GLY SER ASN PHE HIS PHE PHE ALA VAL GLY SEQRES 11QQ 275 GLY ASP PRO LEU GLU MET GLN GLY VAL LEU MET ASN TYR SEQRES 12QQ 275 ARG THR LYS TYR PRO ASP GLY THR ILE THR PRO LYS ASN SEQRES 13QQ 275 PRO THR ALA GLN SER GLN VAL MET ASN THR ASP HIS LYS SEQRES 14QQ 275 ALA TYR LEU ASP LYS ASN ASN ALA TYR PRO VAL GLU CYS SEQRES 15QQ 275 TRP VAL PRO ASP PRO SER ARG ASN GLU ASN THR ARG TYR SEQRES 16QQ 275 PHE GLY THR PHE THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17QQ 275 LEU HIS VAL THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18QQ 275 GLU GLN GLY VAL GLY PRO LEU CYS LYS ALA ASP SER LEU SEQRES 19QQ 275 TYR VAL SER ALA ALA ASP ILE CYS GLY LEU PHE THR ASN SEQRES 20QQ 275 SER SER GLY THR GLN GLN TRP ARG GLY LEU ALA ARG TYR SEQRES 21QQ 275 PHE LYS ILE ARG LEU ARG LYS ARG SER VAL LYS ASN PRO SEQRES 22QQ 275 TYR PRO SEQRES 1aa 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2aa 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3aa 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4aa 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5aa 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6aa 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7aa 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8aa 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9aa 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10aa 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11aa 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12aa 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13aa 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14aa 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15aa 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16aa 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17aa 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18aa 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19aa 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20aa 252 VAL THR VAL SER SER SEQRES 1bb 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2bb 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3bb 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4bb 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5bb 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6bb 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7bb 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8bb 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9bb 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10bb 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11bb 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12bb 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13bb 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14bb 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15bb 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16bb 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17bb 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18bb 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19bb 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20bb 252 VAL THR VAL SER SER SEQRES 1cc 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2cc 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3cc 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4cc 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5cc 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6cc 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7cc 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8cc 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9cc 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10cc 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11cc 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12cc 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13cc 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14cc 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15cc 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16cc 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17cc 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18cc 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19cc 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20cc 252 VAL THR VAL SER SER SEQRES 1dd 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2dd 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3dd 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4dd 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5dd 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6dd 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7dd 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8dd 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9dd 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10dd 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11dd 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12dd 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13dd 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14dd 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15dd 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16dd 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17dd 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18dd 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19dd 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20dd 252 VAL THR VAL SER SER SEQRES 1mm 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2mm 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3mm 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4mm 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5mm 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6mm 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7mm 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8mm 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9mm 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10mm 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11mm 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12mm 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13mm 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14mm 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15mm 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16mm 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17mm 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18mm 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19mm 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20mm 252 VAL THR VAL SER SER SEQRES 1nn 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2nn 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3nn 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4nn 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5nn 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6nn 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7nn 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8nn 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9nn 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10nn 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11nn 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12nn 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13nn 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14nn 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15nn 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16nn 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17nn 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18nn 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19nn 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20nn 252 VAL THR VAL SER SER SEQRES 1oo 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2oo 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3oo 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4oo 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5oo 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6oo 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7oo 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8oo 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9oo 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10oo 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11oo 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12oo 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13oo 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14oo 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15oo 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16oo 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17oo 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18oo 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19oo 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20oo 252 VAL THR VAL SER SER SEQRES 1pp 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2pp 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3pp 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4pp 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5pp 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6pp 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7pp 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8pp 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9pp 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10pp 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11pp 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12pp 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13pp 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14pp 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15pp 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16pp 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17pp 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18pp 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19pp 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20pp 252 VAL THR VAL SER SER SEQRES 1qq 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2qq 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3qq 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4qq 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5qq 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6qq 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7qq 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8qq 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9qq 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10qq 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11qq 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12qq 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13qq 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14qq 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15qq 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16qq 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17qq 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18qq 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19qq 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20qq 252 VAL THR VAL SER SER FORMUL 21 HOH *726(H2 O) HELIX 1 AA1 ASNee 29 ARGee 33 5 5 HELIX 2 AA2 GLUee 81 GLUee 85 5 5 HELIX 3 AA3 THRee 152 TYRee 156 5 5 HELIX 4 AA4 ASPee 186 LYSee 189 5 4 HELIX 5 AA5 ASNee 198 LYSee 200 5 3 HELIX 6 AA6 ASPAA 60 ARGAA 64 5 5 HELIX 7 AA7 GLUAA 82 LEUAA 86 5 5 HELIX 8 AA8 GLYAA 122 ASNAA 128 5 7 HELIX 9 AA9 THRAA 184 VALAA 189 5 6 HELIX 10 AB1 PROAA 205 GLUAA 207 5 3 HELIX 11 AB2 ASPBB 60 ARGBB 64 5 5 HELIX 12 AB3 ASPBB 75 ASPBB 79 5 5 HELIX 13 AB4 GLUBB 82 LEUBB 86 5 5 HELIX 14 AB5 GLYBB 122 ASNBB 128 5 7 HELIX 15 AB6 THRBB 184 VALBB 189 5 6 HELIX 16 AB7 PROBB 205 GLUBB 207 5 3 HELIX 17 AB8 CYSBB 255 ALABB 257 5 3 HELIX 18 AB9 ASPCC 60 ARGCC 64 5 5 HELIX 19 AC1 GLUCC 82 LEUCC 86 5 5 HELIX 20 AC2 GLYCC 122 ASNCC 128 5 7 HELIX 21 AC3 THRCC 184 VALCC 189 5 6 HELIX 22 AC4 PROCC 205 GLUCC 207 5 3 HELIX 23 AC5 CYSCC 255 ALACC 257 5 3 HELIX 24 AC6 ASPDD 60 ARGDD 64 5 5 HELIX 25 AC7 ASPDD 75 ASPDD 79 5 5 HELIX 26 AC8 GLUDD 82 LEUDD 86 5 5 HELIX 27 AC9 GLYDD 122 ASNDD 128 5 7 HELIX 28 AD1 THRDD 184 VALDD 189 5 6 HELIX 29 AD2 PRODD 205 GLUDD 207 5 3 HELIX 30 AD3 CYSDD 255 ALADD 257 5 3 HELIX 31 AD4 ASPEE 60 ARGEE 64 5 5 HELIX 32 AD5 ASPEE 75 ASPEE 79 5 5 HELIX 33 AD6 GLUEE 82 LEUEE 86 5 5 HELIX 34 AD7 GLYEE 122 ASNEE 128 5 7 HELIX 35 AD8 THREE 184 VALEE 189 5 6 HELIX 36 AD9 PROEE 205 GLUEE 207 5 3 HELIX 37 AE1 ASPMM 60 ARGMM 64 5 5 HELIX 38 AE2 ASPMM 75 ASPMM 79 5 5 HELIX 39 AE3 GLUMM 82 LEUMM 86 5 5 HELIX 40 AE4 GLYMM 122 ASNMM 128 5 7 HELIX 41 AE5 THRMM 184 VALMM 189 5 6 HELIX 42 AE6 PROMM 205 GLUMM 207 5 3 HELIX 43 AE7 CYSMM 255 ALAMM 257 5 3 HELIX 44 AE8 ASPNN 60 ARGNN 64 5 5 HELIX 45 AE9 ASPNN 75 ASPNN 79 5 5 HELIX 46 AF1 GLUNN 82 LEUNN 86 5 5 HELIX 47 AF2 GLYNN 122 ASNNN 128 5 7 HELIX 48 AF3 THRNN 184 VALNN 189 5 6 HELIX 49 AF4 PRONN 205 GLUNN 207 5 3 HELIX 50 AF5 CYSNN 255 ALANN 257 5 3 HELIX 51 AF6 ASPOO 60 ARGOO 64 5 5 HELIX 52 AF7 ASPOO 75 ASPOO 79 5 5 HELIX 53 AF8 GLUOO 82 LEUOO 86 5 5 HELIX 54 AF9 ASPOO 102 CYSOO 105 5 4 HELIX 55 AG1 GLYOO 122 ASNOO 128 5 7 HELIX 56 AG2 THROO 184 VALOO 189 5 6 HELIX 57 AG3 PROOO 205 GLUOO 207 5 3 HELIX 58 AG4 ASPPP 60 ARGPP 64 5 5 HELIX 59 AG5 ASPPP 75 ASPPP 79 5 5 HELIX 60 AG6 GLUPP 82 LEUPP 86 5 5 HELIX 61 AG7 GLYPP 122 ASNPP 128 5 7 HELIX 62 AG8 THRPP 184 VALPP 189 5 6 HELIX 63 AG9 PROPP 205 GLUPP 207 5 3 HELIX 64 AH1 CYSPP 255 ALAPP 257 5 3 HELIX 65 AH2 ASPQQ 60 ARGQQ 64 5 5 HELIX 66 AH3 ASPQQ 75 ASPQQ 79 5 5 HELIX 67 AH4 GLUQQ 82 LEUQQ 86 5 5 HELIX 68 AH5 GLYQQ 122 ASNQQ 128 5 7 HELIX 69 AH6 THRQQ 184 VALQQ 189 5 6 HELIX 70 AH7 PROQQ 205 GLUQQ 207 5 3 HELIX 71 AH8 CYSQQ 255 ALAQQ 257 5 3 HELIX 72 AH9 ASNaa 29 ARGaa 33 5 5 HELIX 73 AI1 GLUaa 81 GLUaa 85 5 5 HELIX 74 AI2 THRaa 152 TYRaa 156 5 5 HELIX 75 AI3 ASPaa 186 LYSaa 189 5 4 HELIX 76 AI4 ARGaa 211 THRaa 215 5 5 HELIX 77 AI5 ASNbb 29 ARGbb 33 5 5 HELIX 78 AI6 GLUbb 81 GLUbb 85 5 5 HELIX 79 AI7 THRbb 152 TYRbb 156 5 5 HELIX 80 AI8 ASPbb 186 LYSbb 189 5 4 HELIX 81 AI9 ASNbb 198 LYSbb 200 5 3 HELIX 82 AJ1 ARGbb 211 THRbb 215 5 5 HELIX 83 AJ2 ASNcc 29 ARGcc 33 5 5 HELIX 84 AJ3 GLUcc 81 GLUcc 85 5 5 HELIX 85 AJ4 THRcc 152 TYRcc 156 5 5 HELIX 86 AJ5 ASPcc 186 LYScc 189 5 4 HELIX 87 AJ6 ASNcc 198 LYScc 200 5 3 HELIX 88 AJ7 ARGcc 211 THRcc 215 5 5 HELIX 89 AJ8 ASNdd 29 ARGdd 33 5 5 HELIX 90 AJ9 GLUdd 81 GLUdd 85 5 5 HELIX 91 AK1 THRdd 152 TYRdd 156 5 5 HELIX 92 AK2 ASPdd 186 LYSdd 189 5 4 HELIX 93 AK3 ASNdd 198 LYSdd 200 5 3 HELIX 94 AK4 ARGdd 211 THRdd 215 5 5 HELIX 95 AK5 ASNmm 29 ARGmm 33 5 5 HELIX 96 AK6 GLUmm 81 GLUmm 85 5 5 HELIX 97 AK7 THRmm 152 TYRmm 156 5 5 HELIX 98 AK8 ASPmm 186 LYSmm 189 5 4 HELIX 99 AK9 ASNmm 198 LYSmm 200 5 3 HELIX 100 AL1 ARGmm 211 THRmm 215 5 5 HELIX 101 AL2 ASNnn 29 ARGnn 33 5 5 HELIX 102 AL3 GLUnn 81 GLUnn 85 5 5 HELIX 103 AL4 THRnn 152 TYRnn 156 5 5 HELIX 104 AL5 ASPnn 186 LYSnn 189 5 4 HELIX 105 AL6 ASNnn 198 LYSnn 200 5 3 HELIX 106 AL7 ARGnn 211 THRnn 215 5 5 HELIX 107 AL8 ASNoo 29 ARGoo 33 5 5 HELIX 108 AL9 GLUoo 81 GLUoo 85 5 5 HELIX 109 AM1 THRoo 152 TYRoo 156 5 5 HELIX 110 AM2 ASPoo 186 LYSoo 189 5 4 HELIX 111 AM3 ASNoo 198 LYSoo 200 5 3 HELIX 112 AM4 ARGoo 211 THRoo 215 5 5 HELIX 113 AM5 ASNpp 29 ARGpp 33 5 5 HELIX 114 AM6 GLUpp 81 GLUpp 85 5 5 HELIX 115 AM7 THRpp 152 TYRpp 156 5 5 HELIX 116 AM8 ASPpp 186 LYSpp 189 5 4 HELIX 117 AM9 ASNpp 198 LYSpp 200 5 3 HELIX 118 AN1 ARGpp 211 THRpp 215 5 5 HELIX 119 AN2 ASNqq 29 ARGqq 33 5 5 HELIX 120 AN3 GLUqq 81 GLUqq 85 5 5 HELIX 121 AN4 THRqq 152 TYRqq 156 5 5 HELIX 122 AN5 ASPqq 186 LYSqq 189 5 4 HELIX 123 AN6 ASNqq 198 LYSqq 200 5 3 HELIX 124 AN7 ARGqq 211 THRqq 215 5 5 SHEET 1 AA1 5 SERee 12 VALee 15 0 SHEET 2 AA1 5 THRee 107 VALee 111 1 O ARGee 108 N VALee 13 SHEET 3 AA1 5 ALAee 86 TRPee 93 -1 N ALAee 86 O VALee 109 SHEET 4 AA1 5 HISee 36 HISee 40 -1 N HISee 40 O ASPee 87 SHEET 5 AA1 5 VALee 47 ILEee 50 -1 O VALee 47 N GLNee 39 SHEET 1 AA2 4 SERee 12 VALee 15 0 SHEET 2 AA2 4 THRee 107 VALee 111 1 O ARGee 108 N VALee 13 SHEET 3 AA2 4 ALAee 86 TRPee 93 -1 N ALAee 86 O VALee 109 SHEET 4 AA2 4 TYRee 101 PHEee 103 -1 O VALee 102 N VALee 92 SHEET 1 AA3 3 ALAee 21 GLYee 26 0 SHEET 2 AA3 3 THRee 72 ILEee 77 -1 O ILEee 77 N ALAee 21 SHEET 3 AA3 3 VALee 64 TYRee 69 -1 N SERee 67 O THRee 74 SHEET 1 AA4 4 GLNee 127 SERee 131 0 SHEET 2 AA4 4 LEUee 142 SERee 149 -1 O ALAee 147 N VALee 129 SHEET 3 AA4 4 THRee 202 METee 207 -1 O METee 207 N LEUee 142 SHEET 4 AA4 4 PHEee 192 ASPee 197 -1 N ASPee 197 O THRee 202 SHEET 1 AA5 5 THRee 182 TYRee 184 0 SHEET 2 AA5 5 LEUee 169 ILEee 175 -1 N SERee 174 O TYRee 183 SHEET 3 AA5 5 METee 158 GLNee 163 -1 N ARGee 162 O GLUee 170 SHEET 4 AA5 5 ALAee 216 LYSee 222 -1 O TYRee 219 N VALee 161 SHEET 5 AA5 5 TYRee 237 TRPee 238 -1 O TYRee 237 N LYSee 222 SHEET 1 AA6 5 THRee 182 TYRee 184 0 SHEET 2 AA6 5 LEUee 169 ILEee 175 -1 N SERee 174 O TYRee 183 SHEET 3 AA6 5 METee 158 GLNee 163 -1 N ARGee 162 O GLUee 170 SHEET 4 AA6 5 ALAee 216 LYSee 222 -1 O TYRee 219 N VALee 161 SHEET 5 AA6 5 THRee 242 VALee 244 -1 O THRee 242 N TYRee 218 SHEET 1 AA7 4 THRAA 46 LEUAA 52 0 SHEET 2 AA7 4 ALAAA 284 VALAA 296 -1 O PHEAA 287 N CYSAA 50 SHEET 3 AA7 4 LEUAA 108 ILEAA 121 -1 N VALAA 114 O ARGAA 290 SHEET 4 AA7 4 THRAA 243 VALAA 244 -1 O THRAA 243 N VALAA 116 SHEET 1 AA8 4 THRAA 46 LEUAA 52 0 SHEET 2 AA8 4 ALAAA 284 VALAA 296 -1 O PHEAA 287 N CYSAA 50 SHEET 3 AA8 4 LEUAA 108 ILEAA 121 -1 N VALAA 114 O ARGAA 290 SHEET 4 AA8 4 LEUAA 254 CYSAA 255 -1 O CYSAA 255 N TRPAA 111 SHEET 1 AA9 3 SERAA 90 PROAA 95 0 SHEET 2 AA9 3 SERAA 259 THRAA 272 -1 O LEUAA 260 N ILEAA 94 SHEET 3 AA9 3 GLNAA 278 GLYAA 282 -1 O GLNAA 279 N PHEAA 271 SHEET 1 AB1 5 SERAA 90 PROAA 95 0 SHEET 2 AB1 5 SERAA 259 THRAA 272 -1 O LEUAA 260 N ILEAA 94 SHEET 3 AB1 5 ASNAA 149 GLYAA 156 -1 N GLYAA 156 O TYRAA 261 SHEET 4 AB1 5 THRAA 219 THRAA 226 -1 O THRAA 226 N ASNAA 149 SHEET 5 AB1 5 VALEE 234 THREE 238 -1 O LEUEE 235 N PHEAA 225 SHEET 1 AB2 3 LYSAA 195 TYRAA 197 0 SHEET 2 AB2 3 GLUAA 161 GLYAA 164 -1 N METAA 162 O ALAAA 196 SHEET 3 AB2 3 TRPAA 209 PROAA 211 -1 O VALAA 210 N GLNAA 163 SHEET 1 AB3 5 VALAA 234 THRAA 238 0 SHEET 2 AB3 5 THRBB 219 THRBB 226 -1 O GLYBB 223 N VALAA 237 SHEET 3 AB3 5 ASNBB 149 GLYBB 156 -1 N VALBB 155 O ARGBB 220 SHEET 4 AB3 5 SERBB 259 THRBB 272 -1 O TYRBB 261 N GLYBB 156 SHEET 5 AB3 5 SERBB 90 PROBB 95 -1 N ILEBB 94 O LEUBB 260 SHEET 1 AB4 5 VALAA 234 THRAA 238 0 SHEET 2 AB4 5 THRBB 219 THRBB 226 -1 O GLYBB 223 N VALAA 237 SHEET 3 AB4 5 ASNBB 149 GLYBB 156 -1 N VALBB 155 O ARGBB 220 SHEET 4 AB4 5 SERBB 259 THRBB 272 -1 O TYRBB 261 N GLYBB 156 SHEET 5 AB4 5 GLNBB 278 GLYBB 282 -1 O GLNBB 279 N PHEBB 271 SHEET 1 AB5 3 VALBB 35 VALBB 38 0 SHEET 2 AB5 3 ALABB 284 VALBB 296 -1 O SERBB 295 N LEUBB 36 SHEET 3 AB5 3 THRBB 46 LEUBB 52 -1 N CYSBB 50 O PHEBB 287 SHEET 1 AB6 4 VALBB 35 VALBB 38 0 SHEET 2 AB6 4 ALABB 284 VALBB 296 -1 O SERBB 295 N LEUBB 36 SHEET 3 AB6 4 LEUBB 108 ILEBB 121 -1 N VALBB 114 O ARGBB 290 SHEET 4 AB6 4 THRBB 243 VALBB 244 -1 O THRBB 243 N VALBB 116 SHEET 1 AB7 3 LYSBB 195 TYRBB 197 0 SHEET 2 AB7 3 GLUBB 161 GLYBB 164 -1 N METBB 162 O ALABB 196 SHEET 3 AB7 3 TRPBB 209 PROBB 211 -1 O VALBB 210 N GLNBB 163 SHEET 1 AB8 5 VALBB 234 THRBB 238 0 SHEET 2 AB8 5 THRCC 219 THRCC 226 -1 O PHECC 225 N LEUBB 235 SHEET 3 AB8 5 ASNCC 149 GLYCC 156 -1 N VALCC 155 O ARGCC 220 SHEET 4 AB8 5 SERCC 259 THRCC 272 -1 O TYRCC 261 N GLYCC 156 SHEET 5 AB8 5 SERCC 90 PROCC 95 -1 N ILECC 94 O LEUCC 260 SHEET 1 AB9 5 VALBB 234 THRBB 238 0 SHEET 2 AB9 5 THRCC 219 THRCC 226 -1 O PHECC 225 N LEUBB 235 SHEET 3 AB9 5 ASNCC 149 GLYCC 156 -1 N VALCC 155 O ARGCC 220 SHEET 4 AB9 5 SERCC 259 THRCC 272 -1 O TYRCC 261 N GLYCC 156 SHEET 5 AB9 5 GLNCC 278 GLYCC 282 -1 O GLNCC 279 N PHECC 271 SHEET 1 AC1 3 VALCC 35 LYSCC 39 0 SHEET 2 AC1 3 ALACC 284 VALCC 296 -1 O SERCC 295 N LEUCC 36 SHEET 3 AC1 3 ILECC 45 LEUCC 52 -1 N CYSCC 50 O PHECC 287 SHEET 1 AC2 4 VALCC 35 LYSCC 39 0 SHEET 2 AC2 4 ALACC 284 VALCC 296 -1 O SERCC 295 N LEUCC 36 SHEET 3 AC2 4 LEUCC 109 ILECC 121 -1 N VALCC 114 O ARGCC 290 SHEET 4 AC2 4 THRCC 243 VALCC 244 -1 O THRCC 243 N VALCC 116 SHEET 1 AC3 3 LYSCC 195 TYRCC 197 0 SHEET 2 AC3 3 GLUCC 161 GLYCC 164 -1 N METCC 162 O ALACC 196 SHEET 3 AC3 3 TRPCC 209 PROCC 211 -1 O VALCC 210 N GLNCC 163 SHEET 1 AC4 5 VALCC 234 THRCC 238 0 SHEET 2 AC4 5 THRDD 219 THRDD 226 -1 O PHEDD 225 N LEUCC 235 SHEET 3 AC4 5 ASNDD 149 GLYDD 156 -1 N VALDD 155 O ARGDD 220 SHEET 4 AC4 5 SERDD 259 THRDD 272 -1 O TYRDD 261 N GLYDD 156 SHEET 5 AC4 5 SERDD 90 PRODD 95 -1 N ILEDD 94 O LEUDD 260 SHEET 1 AC5 5 VALCC 234 THRCC 238 0 SHEET 2 AC5 5 THRDD 219 THRDD 226 -1 O PHEDD 225 N LEUCC 235 SHEET 3 AC5 5 ASNDD 149 GLYDD 156 -1 N VALDD 155 O ARGDD 220 SHEET 4 AC5 5 SERDD 259 THRDD 272 -1 O TYRDD 261 N GLYDD 156 SHEET 5 AC5 5 GLNDD 278 GLYDD 282 -1 O GLNDD 279 N PHEDD 271 SHEET 1 AC6 4 ILEDD 45 LEUDD 52 0 SHEET 2 AC6 4 ALADD 284 SERDD 295 -1 O LEUDD 291 N THRDD 46 SHEET 3 AC6 4 LEUDD 109 ILEDD 121 -1 N GLUDD 112 O ARGDD 292 SHEET 4 AC6 4 THRDD 243 VALDD 244 -1 O THRDD 243 N VALDD 116 SHEET 1 AC7 3 LYSDD 195 TYRDD 197 0 SHEET 2 AC7 3 GLUDD 161 GLYDD 164 -1 N METDD 162 O ALADD 196 SHEET 3 AC7 3 TRPDD 209 PRODD 211 -1 O VALDD 210 N GLNDD 163 SHEET 1 AC8 5 VALDD 234 THRDD 238 0 SHEET 2 AC8 5 THREE 219 THREE 226 -1 O GLYEE 223 N VALDD 237 SHEET 3 AC8 5 ASNEE 149 GLYEE 156 -1 N ASNEE 149 O THREE 226 SHEET 4 AC8 5 SEREE 259 THREE 272 -1 O TYREE 261 N GLYEE 156 SHEET 5 AC8 5 SEREE 90 PROEE 95 -1 N SEREE 90 O ALAEE 264 SHEET 1 AC9 5 VALDD 234 THRDD 238 0 SHEET 2 AC9 5 THREE 219 THREE 226 -1 O GLYEE 223 N VALDD 237 SHEET 3 AC9 5 ASNEE 149 GLYEE 156 -1 N ASNEE 149 O THREE 226 SHEET 4 AC9 5 SEREE 259 THREE 272 -1 O TYREE 261 N GLYEE 156 SHEET 5 AC9 5 GLNEE 278 GLYEE 282 -1 O GLNEE 279 N PHEEE 271 SHEET 1 AD1 4 VALEE 35 VALEE 38 0 SHEET 2 AD1 4 ALAEE 284 LYSEE 297 -1 O SEREE 295 N LEUEE 36 SHEET 3 AD1 4 ASNEE 107 ILEEE 121 -1 N VALEE 114 O ARGEE 290 SHEET 4 AD1 4 THREE 243 VALEE 244 -1 O THREE 243 N VALEE 116 SHEET 1 AD2 4 ILEEE 45 LEUEE 52 0 SHEET 2 AD2 4 ALAEE 284 LYSEE 297 -1 O PHEEE 287 N CYSEE 50 SHEET 3 AD2 4 ASNEE 107 ILEEE 121 -1 N VALEE 114 O ARGEE 290 SHEET 4 AD2 4 LEUEE 254 CYSEE 255 -1 O CYSEE 255 N TRPEE 111 SHEET 1 AD3 5 GLUEE 101 ASPEE 102 0 SHEET 2 AD3 5 ILEMM 45 LEUMM 52 1 O PHEMM 51 N GLUEE 101 SHEET 3 AD3 5 ARGMM 285 VALMM 296 -1 O LEUMM 291 N THRMM 46 SHEET 4 AD3 5 LEUMM 108 VALMM 120 -1 N VALMM 114 O ARGMM 290 SHEET 5 AD3 5 THRMM 243 VALMM 244 -1 O THRMM 243 N VALMM 116 SHEET 1 AD4 3 LYSEE 195 TYREE 197 0 SHEET 2 AD4 3 GLUEE 161 GLYEE 164 -1 N METEE 162 O ALAEE 196 SHEET 3 AD4 3 TRPEE 209 PROEE 211 -1 O VALEE 210 N GLNEE 163 SHEET 1 AD5 3 SERMM 90 PROMM 95 0 SHEET 2 AD5 3 SERMM 259 THRMM 272 -1 O LEUMM 260 N ILEMM 94 SHEET 3 AD5 3 GLNMM 278 GLYMM 282 -1 O GLNMM 279 N PHEMM 271 SHEET 1 AD6 5 SERMM 90 PROMM 95 0 SHEET 2 AD6 5 SERMM 259 THRMM 272 -1 O LEUMM 260 N ILEMM 94 SHEET 3 AD6 5 ASNMM 149 GLYMM 156 -1 N GLYMM 156 O TYRMM 261 SHEET 4 AD6 5 THRMM 219 THRMM 226 -1 O ARGMM 220 N VALMM 155 SHEET 5 AD6 5 VALQQ 234 THRQQ 238 -1 O LEUQQ 235 N PHEMM 225 SHEET 1 AD7 3 LYSMM 195 TYRMM 197 0 SHEET 2 AD7 3 GLUMM 161 GLYMM 164 -1 N METMM 162 O ALAMM 196 SHEET 3 AD7 3 TRPMM 209 PROMM 211 -1 O VALMM 210 N GLNMM 163 SHEET 1 AD8 5 VALMM 234 THRMM 238 0 SHEET 2 AD8 5 THRNN 219 THRNN 226 -1 O PHENN 225 N LEUMM 235 SHEET 3 AD8 5 ASNNN 149 GLYNN 156 -1 N VALNN 155 O ARGNN 220 SHEET 4 AD8 5 SERNN 259 THRNN 272 -1 O TYRNN 261 N GLYNN 156 SHEET 5 AD8 5 SERNN 90 PRONN 95 -1 N ILENN 94 O LEUNN 260 SHEET 1 AD9 5 VALMM 234 THRMM 238 0 SHEET 2 AD9 5 THRNN 219 THRNN 226 -1 O PHENN 225 N LEUMM 235 SHEET 3 AD9 5 ASNNN 149 GLYNN 156 -1 N VALNN 155 O ARGNN 220 SHEET 4 AD9 5 SERNN 259 THRNN 272 -1 O TYRNN 261 N GLYNN 156 SHEET 5 AD9 5 GLNNN 278 GLYNN 282 -1 O GLNNN 279 N PHENN 271 SHEET 1 AE1 4 ILENN 45 LEUNN 52 0 SHEET 2 AE1 4 ARGNN 285 VALNN 296 -1 O PHENN 287 N CYSNN 50 SHEET 3 AE1 4 LEUNN 108 VALNN 120 -1 N VALNN 114 O ARGNN 290 SHEET 4 AE1 4 THRNN 243 VALNN 244 -1 O THRNN 243 N VALNN 116 SHEET 1 AE2 3 LYSNN 195 TYRNN 197 0 SHEET 2 AE2 3 GLUNN 161 GLYNN 164 -1 N METNN 162 O ALANN 196 SHEET 3 AE2 3 TRPNN 209 PRONN 211 -1 O VALNN 210 N GLNNN 163 SHEET 1 AE3 5 VALNN 234 THRNN 238 0 SHEET 2 AE3 5 THROO 219 THROO 226 -1 O PHEOO 225 N LEUNN 235 SHEET 3 AE3 5 ASNOO 149 GLYOO 156 -1 N ASNOO 149 O THROO 226 SHEET 4 AE3 5 SEROO 259 THROO 272 -1 O TYROO 261 N GLYOO 156 SHEET 5 AE3 5 SEROO 90 PROOO 95 -1 N SEROO 90 O ALAOO 264 SHEET 1 AE4 5 VALNN 234 THRNN 238 0 SHEET 2 AE4 5 THROO 219 THROO 226 -1 O PHEOO 225 N LEUNN 235 SHEET 3 AE4 5 ASNOO 149 GLYOO 156 -1 N ASNOO 149 O THROO 226 SHEET 4 AE4 5 SEROO 259 THROO 272 -1 O TYROO 261 N GLYOO 156 SHEET 5 AE4 5 GLNOO 278 GLYOO 282 -1 O GLNOO 279 N PHEOO 271 SHEET 1 AE5 4 VALOO 35 VALOO 38 0 SHEET 2 AE5 4 ARGOO 285 LYSOO 297 -1 O SEROO 295 N LEUOO 36 SHEET 3 AE5 4 ASNOO 107 VALOO 120 -1 N VALOO 114 O ARGOO 290 SHEET 4 AE5 4 THROO 243 VALOO 244 -1 O THROO 243 N VALOO 116 SHEET 1 AE6 4 ILEOO 45 LEUOO 52 0 SHEET 2 AE6 4 ARGOO 285 LYSOO 297 -1 O PHEOO 287 N CYSOO 50 SHEET 3 AE6 4 ASNOO 107 VALOO 120 -1 N VALOO 114 O ARGOO 290 SHEET 4 AE6 4 LEUOO 254 CYSOO 255 -1 O CYSOO 255 N TRPOO 111 SHEET 1 AE7 3 LYSOO 195 TYROO 197 0 SHEET 2 AE7 3 GLUOO 161 GLYOO 164 -1 N METOO 162 O ALAOO 196 SHEET 3 AE7 3 TRPOO 209 PROOO 211 -1 O VALOO 210 N GLNOO 163 SHEET 1 AE8 5 VALOO 234 THROO 238 0 SHEET 2 AE8 5 THRPP 219 THRPP 226 -1 O PHEPP 225 N LEUOO 235 SHEET 3 AE8 5 ASNPP 149 GLYPP 156 -1 N VALPP 155 O ARGPP 220 SHEET 4 AE8 5 SERPP 259 THRPP 272 -1 O TYRPP 261 N GLYPP 156 SHEET 5 AE8 5 SERPP 90 PROPP 95 -1 N ILEPP 94 O LEUPP 260 SHEET 1 AE9 5 VALOO 234 THROO 238 0 SHEET 2 AE9 5 THRPP 219 THRPP 226 -1 O PHEPP 225 N LEUOO 235 SHEET 3 AE9 5 ASNPP 149 GLYPP 156 -1 N VALPP 155 O ARGPP 220 SHEET 4 AE9 5 SERPP 259 THRPP 272 -1 O TYRPP 261 N GLYPP 156 SHEET 5 AE9 5 GLNPP 278 GLYPP 282 -1 O GLNPP 279 N PHEPP 271 SHEET 1 AF1 3 VALPP 38 LYSPP 39 0 SHEET 2 AF1 3 ALAPP 284 SERPP 295 -1 O LYSPP 293 N LYSPP 39 SHEET 3 AF1 3 ILEPP 45 LEUPP 52 -1 N CYSPP 50 O PHEPP 287 SHEET 1 AF2 4 VALPP 38 LYSPP 39 0 SHEET 2 AF2 4 ALAPP 284 SERPP 295 -1 O LYSPP 293 N LYSPP 39 SHEET 3 AF2 4 LEUPP 109 ILEPP 121 -1 N VALPP 114 O ARGPP 290 SHEET 4 AF2 4 THRPP 243 VALPP 244 -1 O THRPP 243 N VALPP 116 SHEET 1 AF3 3 LYSPP 195 TYRPP 197 0 SHEET 2 AF3 3 GLUPP 161 GLYPP 164 -1 N METPP 162 O ALAPP 196 SHEET 3 AF3 3 TRPPP 209 PROPP 211 -1 O VALPP 210 N GLNPP 163 SHEET 1 AF4 5 VALPP 234 THRPP 238 0 SHEET 2 AF4 5 THRQQ 219 THRQQ 226 -1 O GLYQQ 223 N VALPP 237 SHEET 3 AF4 5 ASNQQ 149 GLYQQ 156 -1 N VALQQ 155 O ARGQQ 220 SHEET 4 AF4 5 SERQQ 259 THRQQ 272 -1 O TYRQQ 261 N GLYQQ 156 SHEET 5 AF4 5 SERQQ 90 PROQQ 95 -1 N ILEQQ 94 O LEUQQ 260 SHEET 1 AF5 5 VALPP 234 THRPP 238 0 SHEET 2 AF5 5 THRQQ 219 THRQQ 226 -1 O GLYQQ 223 N VALPP 237 SHEET 3 AF5 5 ASNQQ 149 GLYQQ 156 -1 N VALQQ 155 O ARGQQ 220 SHEET 4 AF5 5 SERQQ 259 THRQQ 272 -1 O TYRQQ 261 N GLYQQ 156 SHEET 5 AF5 5 GLNQQ 278 GLYQQ 282 -1 O GLNQQ 279 N PHEQQ 271 SHEET 1 AF6 3 VALQQ 35 LEUQQ 36 0 SHEET 2 AF6 3 ALAQQ 284 VALQQ 296 -1 O SERQQ 295 N LEUQQ 36 SHEET 3 AF6 3 THRQQ 46 LEUQQ 52 -1 N CYSQQ 50 O PHEQQ 287 SHEET 1 AF7 4 VALQQ 35 LEUQQ 36 0 SHEET 2 AF7 4 ALAQQ 284 VALQQ 296 -1 O SERQQ 295 N LEUQQ 36 SHEET 3 AF7 4 LEUQQ 108 ILEQQ 121 -1 N VALQQ 114 O ARGQQ 290 SHEET 4 AF7 4 THRQQ 243 VALQQ 244 -1 O THRQQ 243 N VALQQ 116 SHEET 1 AF8 3 LYSQQ 195 TYRQQ 197 0 SHEET 2 AF8 3 GLUQQ 161 GLYQQ 164 -1 N METQQ 162 O ALAQQ 196 SHEET 3 AF8 3 TRPQQ 209 PROQQ 211 -1 O VALQQ 210 N GLNQQ 163 SHEET 1 AF9 5 SERaa 12 SERaa 14 0 SHEET 2 AF9 5 THRaa 107 THRaa 110 1 O ARGaa 108 N VALaa 13 SHEET 3 AF9 5 ALAaa 86 TRPaa 93 -1 N ALAaa 86 O VALaa 109 SHEET 4 AF9 5 HISaa 36 HISaa 40 -1 N HISaa 40 O ASPaa 87 SHEET 5 AF9 5 VALaa 47 ILEaa 50 -1 O VALaa 47 N GLNaa 39 SHEET 1 AG1 4 SERaa 12 SERaa 14 0 SHEET 2 AG1 4 THRaa 107 THRaa 110 1 O ARGaa 108 N VALaa 13 SHEET 3 AG1 4 ALAaa 86 TRPaa 93 -1 N ALAaa 86 O VALaa 109 SHEET 4 AG1 4 TYRaa 101 PHEaa 103 -1 O VALaa 102 N VALaa 92 SHEET 1 AG2 3 ALAaa 21 GLYaa 26 0 SHEET 2 AG2 3 THRaa 72 ILEaa 77 -1 O ILEaa 77 N ALAaa 21 SHEET 3 AG2 3 VALaa 64 TYRaa 69 -1 N SERaa 67 O THRaa 74 SHEET 1 AG3 4 GLNaa 127 SERaa 131 0 SHEET 2 AG3 4 LEUaa 142 SERaa 149 -1 O ALAaa 147 N VALaa 129 SHEET 3 AG3 4 THRaa 202 METaa 207 -1 O METaa 207 N LEUaa 142 SHEET 4 AG3 4 PHEaa 192 ASPaa 197 -1 N THRaa 193 O GLNaa 206 SHEET 1 AG4 5 TYRaa 183 TYRaa 184 0 SHEET 2 AG4 5 LEUaa 169 ILEaa 175 -1 N SERaa 174 O TYRaa 183 SHEET 3 AG4 5 METaa 158 GLNaa 163 -1 N ARGaa 162 O GLUaa 170 SHEET 4 AG4 5 ALAaa 216 LYSaa 222 -1 O TYRaa 219 N VALaa 161 SHEET 5 AG4 5 TYRaa 237 TRPaa 238 -1 O TYRaa 237 N LYSaa 222 SHEET 1 AG5 5 TYRaa 183 TYRaa 184 0 SHEET 2 AG5 5 LEUaa 169 ILEaa 175 -1 N SERaa 174 O TYRaa 183 SHEET 3 AG5 5 METaa 158 GLNaa 163 -1 N ARGaa 162 O GLUaa 170 SHEET 4 AG5 5 ALAaa 216 LYSaa 222 -1 O TYRaa 219 N VALaa 161 SHEET 5 AG5 5 THRaa 242 VALaa 244 -1 O THRaa 242 N TYRaa 218 SHEET 1 AG6 5 SERbb 12 VALbb 15 0 SHEET 2 AG6 5 THRbb 107 VALbb 111 1 O ARGbb 108 N VALbb 13 SHEET 3 AG6 5 ALAbb 86 TRPbb 93 -1 N ALAbb 86 O VALbb 109 SHEET 4 AG6 5 HISbb 36 HISbb 40 -1 N HISbb 40 O ASPbb 87 SHEET 5 AG6 5 VALbb 47 ILEbb 50 -1 O VALbb 47 N GLNbb 39 SHEET 1 AG7 4 SERbb 12 VALbb 15 0 SHEET 2 AG7 4 THRbb 107 VALbb 111 1 O ARGbb 108 N VALbb 13 SHEET 3 AG7 4 ALAbb 86 TRPbb 93 -1 N ALAbb 86 O VALbb 109 SHEET 4 AG7 4 TYRbb 101 PHEbb 103 -1 O VALbb 102 N VALbb 92 SHEET 1 AG8 3 ALAbb 21 GLYbb 26 0 SHEET 2 AG8 3 THRbb 72 ILEbb 77 -1 O ILEbb 77 N ALAbb 21 SHEET 3 AG8 3 VALbb 64 TYRbb 69 -1 N SERbb 65 O THRbb 76 SHEET 1 AG9 4 GLNbb 127 SERbb 131 0 SHEET 2 AG9 4 LEUbb 142 SERbb 149 -1 O ALAbb 147 N VALbb 129 SHEET 3 AG9 4 THRbb 202 METbb 207 -1 O METbb 207 N LEUbb 142 SHEET 4 AG9 4 PHEbb 192 ASPbb 197 -1 N ASPbb 197 O THRbb 202 SHEET 1 AH1 5 THRbb 182 TYRbb 184 0 SHEET 2 AH1 5 LEUbb 169 ILEbb 175 -1 N SERbb 174 O TYRbb 183 SHEET 3 AH1 5 METbb 158 GLNbb 163 -1 N ARGbb 162 O GLUbb 170 SHEET 4 AH1 5 ALAbb 216 LYSbb 222 -1 O TYRbb 219 N VALbb 161 SHEET 5 AH1 5 TYRbb 237 TRPbb 238 -1 O TYRbb 237 N LYSbb 222 SHEET 1 AH2 5 THRbb 182 TYRbb 184 0 SHEET 2 AH2 5 LEUbb 169 ILEbb 175 -1 N SERbb 174 O TYRbb 183 SHEET 3 AH2 5 METbb 158 GLNbb 163 -1 N ARGbb 162 O GLUbb 170 SHEET 4 AH2 5 ALAbb 216 LYSbb 222 -1 O TYRbb 219 N VALbb 161 SHEET 5 AH2 5 THRbb 242 VALbb 244 -1 O THRbb 242 N TYRbb 218 SHEET 1 AH3 5 SERcc 12 SERcc 14 0 SHEET 2 AH3 5 THRcc 107 THRcc 110 1 O ARGcc 108 N VALcc 13 SHEET 3 AH3 5 ALAcc 86 TRPcc 93 -1 N ALAcc 86 O VALcc 109 SHEET 4 AH3 5 HIScc 36 HIScc 40 -1 N HIScc 40 O ASPcc 87 SHEET 5 AH3 5 VALcc 47 ILEcc 50 -1 O VALcc 47 N GLNcc 39 SHEET 1 AH4 4 SERcc 12 SERcc 14 0 SHEET 2 AH4 4 THRcc 107 THRcc 110 1 O ARGcc 108 N VALcc 13 SHEET 3 AH4 4 ALAcc 86 TRPcc 93 -1 N ALAcc 86 O VALcc 109 SHEET 4 AH4 4 TYRcc 101 PHEcc 103 -1 O VALcc 102 N VALcc 92 SHEET 1 AH5 3 ALAcc 21 GLYcc 26 0 SHEET 2 AH5 3 THRcc 72 ILEcc 77 -1 O ILEcc 77 N ALAcc 21 SHEET 3 AH5 3 VALcc 64 TYRcc 69 -1 N SERcc 65 O THRcc 76 SHEET 1 AH6 4 GLNcc 127 SERcc 131 0 SHEET 2 AH6 4 LEUcc 142 SERcc 149 -1 O ALAcc 147 N VALcc 129 SHEET 3 AH6 4 THRcc 202 METcc 207 -1 O METcc 207 N LEUcc 142 SHEET 4 AH6 4 PHEcc 192 ASPcc 197 -1 N ASPcc 197 O THRcc 202 SHEET 1 AH7 5 THRcc 182 TYRcc 184 0 SHEET 2 AH7 5 LEUcc 169 ILEcc 175 -1 N SERcc 174 O TYRcc 183 SHEET 3 AH7 5 METcc 158 GLNcc 163 -1 N ARGcc 162 O GLUcc 170 SHEET 4 AH7 5 ALAcc 216 LYScc 222 -1 O TYRcc 219 N VALcc 161 SHEET 5 AH7 5 TYRcc 237 TRPcc 238 -1 O TYRcc 237 N LYScc 222 SHEET 1 AH8 5 THRcc 182 TYRcc 184 0 SHEET 2 AH8 5 LEUcc 169 ILEcc 175 -1 N SERcc 174 O TYRcc 183 SHEET 3 AH8 5 METcc 158 GLNcc 163 -1 N ARGcc 162 O GLUcc 170 SHEET 4 AH8 5 ALAcc 216 LYScc 222 -1 O TYRcc 219 N VALcc 161 SHEET 5 AH8 5 THRcc 242 VALcc 244 -1 O THRcc 242 N TYRcc 218 SHEET 1 AH9 5 SERdd 12 VALdd 15 0 SHEET 2 AH9 5 THRdd 107 VALdd 111 1 O ARGdd 108 N VALdd 13 SHEET 3 AH9 5 ALAdd 86 TRPdd 93 -1 N ALAdd 86 O VALdd 109 SHEET 4 AH9 5 HISdd 36 HISdd 40 -1 N HISdd 40 O ASPdd 87 SHEET 5 AH9 5 VALdd 47 ILEdd 50 -1 O VALdd 47 N GLNdd 39 SHEET 1 AI1 4 SERdd 12 VALdd 15 0 SHEET 2 AI1 4 THRdd 107 VALdd 111 1 O ARGdd 108 N VALdd 13 SHEET 3 AI1 4 ALAdd 86 TRPdd 93 -1 N ALAdd 86 O VALdd 109 SHEET 4 AI1 4 TYRdd 101 PHEdd 103 -1 O VALdd 102 N VALdd 92 SHEET 1 AI2 3 ALAdd 21 GLYdd 26 0 SHEET 2 AI2 3 THRdd 72 ILEdd 77 -1 O ILEdd 77 N ALAdd 21 SHEET 3 AI2 3 VALdd 64 TYRdd 69 -1 N SERdd 65 O THRdd 76 SHEET 1 AI3 4 GLNdd 127 SERdd 131 0 SHEET 2 AI3 4 LEUdd 142 SERdd 149 -1 O ALAdd 147 N VALdd 129 SHEET 3 AI3 4 THRdd 202 METdd 207 -1 O METdd 207 N LEUdd 142 SHEET 4 AI3 4 PHEdd 192 ASPdd 197 -1 N ASPdd 197 O THRdd 202 SHEET 1 AI4 5 THRdd 182 TYRdd 184 0 SHEET 2 AI4 5 LEUdd 169 ILEdd 175 -1 N SERdd 174 O TYRdd 183 SHEET 3 AI4 5 METdd 158 GLNdd 163 -1 N ARGdd 162 O GLUdd 170 SHEET 4 AI4 5 ALAdd 216 LYSdd 222 -1 O TYRdd 219 N VALdd 161 SHEET 5 AI4 5 TYRdd 237 TRPdd 238 -1 O TYRdd 237 N LYSdd 222 SHEET 1 AI5 5 THRdd 182 TYRdd 184 0 SHEET 2 AI5 5 LEUdd 169 ILEdd 175 -1 N SERdd 174 O TYRdd 183 SHEET 3 AI5 5 METdd 158 GLNdd 163 -1 N ARGdd 162 O GLUdd 170 SHEET 4 AI5 5 ALAdd 216 LYSdd 222 -1 O TYRdd 219 N VALdd 161 SHEET 5 AI5 5 THRdd 242 VALdd 244 -1 O THRdd 242 N TYRdd 218 SHEET 1 AI6 5 SERmm 12 VALmm 15 0 SHEET 2 AI6 5 THRmm 107 VALmm 111 1 O ARGmm 108 N VALmm 13 SHEET 3 AI6 5 ALAmm 86 TRPmm 93 -1 N ALAmm 86 O VALmm 109 SHEET 4 AI6 5 HISmm 36 HISmm 40 -1 N HISmm 40 O ASPmm 87 SHEET 5 AI6 5 VALmm 47 ILEmm 50 -1 O VALmm 47 N GLNmm 39 SHEET 1 AI7 4 SERmm 12 VALmm 15 0 SHEET 2 AI7 4 THRmm 107 VALmm 111 1 O ARGmm 108 N VALmm 13 SHEET 3 AI7 4 ALAmm 86 TRPmm 93 -1 N ALAmm 86 O VALmm 109 SHEET 4 AI7 4 TYRmm 101 PHEmm 103 -1 O VALmm 102 N VALmm 92 SHEET 1 AI8 3 ALAmm 21 GLYmm 26 0 SHEET 2 AI8 3 THRmm 72 ILEmm 77 -1 O ILEmm 77 N ALAmm 21 SHEET 3 AI8 3 VALmm 64 TYRmm 69 -1 N SERmm 65 O THRmm 76 SHEET 1 AI9 4 GLNmm 127 SERmm 131 0 SHEET 2 AI9 4 LEUmm 142 SERmm 149 -1 O ALAmm 147 N VALmm 129 SHEET 3 AI9 4 THRmm 202 METmm 207 -1 O METmm 207 N LEUmm 142 SHEET 4 AI9 4 PHEmm 192 ASPmm 197 -1 N ASPmm 197 O THRmm 202 SHEET 1 AJ1 5 THRmm 182 TYRmm 184 0 SHEET 2 AJ1 5 LEUmm 169 ILEmm 175 -1 N SERmm 174 O TYRmm 183 SHEET 3 AJ1 5 METmm 158 GLNmm 163 -1 N ARGmm 162 O GLUmm 170 SHEET 4 AJ1 5 ALAmm 216 LYSmm 222 -1 O TYRmm 219 N VALmm 161 SHEET 5 AJ1 5 TYRmm 237 TRPmm 238 -1 O TYRmm 237 N LYSmm 222 SHEET 1 AJ2 5 THRmm 182 TYRmm 184 0 SHEET 2 AJ2 5 LEUmm 169 ILEmm 175 -1 N SERmm 174 O TYRmm 183 SHEET 3 AJ2 5 METmm 158 GLNmm 163 -1 N ARGmm 162 O GLUmm 170 SHEET 4 AJ2 5 ALAmm 216 LYSmm 222 -1 O TYRmm 219 N VALmm 161 SHEET 5 AJ2 5 THRmm 242 VALmm 244 -1 O THRmm 242 N TYRmm 218 SHEET 1 AJ3 5 SERnn 12 VALnn 15 0 SHEET 2 AJ3 5 THRnn 107 VALnn 111 1 O ARGnn 108 N VALnn 13 SHEET 3 AJ3 5 ALAnn 86 TRPnn 93 -1 N ALAnn 86 O VALnn 109 SHEET 4 AJ3 5 HISnn 36 HISnn 40 -1 N HISnn 40 O ASPnn 87 SHEET 5 AJ3 5 VALnn 47 ILEnn 50 -1 O VALnn 47 N GLNnn 39 SHEET 1 AJ4 4 SERnn 12 VALnn 15 0 SHEET 2 AJ4 4 THRnn 107 VALnn 111 1 O ARGnn 108 N VALnn 13 SHEET 3 AJ4 4 ALAnn 86 TRPnn 93 -1 N ALAnn 86 O VALnn 109 SHEET 4 AJ4 4 TYRnn 101 PHEnn 103 -1 O VALnn 102 N VALnn 92 SHEET 1 AJ5 3 ALAnn 21 GLYnn 26 0 SHEET 2 AJ5 3 THRnn 72 ILEnn 77 -1 O ILEnn 77 N ALAnn 21 SHEET 3 AJ5 3 VALnn 64 TYRnn 69 -1 N SERnn 65 O THRnn 76 SHEET 1 AJ6 4 GLNnn 127 SERnn 131 0 SHEET 2 AJ6 4 LEUnn 142 SERnn 149 -1 O ALAnn 147 N VALnn 129 SHEET 3 AJ6 4 THRnn 202 METnn 207 -1 O METnn 207 N LEUnn 142 SHEET 4 AJ6 4 PHEnn 192 ASPnn 197 -1 N ASPnn 197 O THRnn 202 SHEET 1 AJ7 5 THRnn 182 TYRnn 184 0 SHEET 2 AJ7 5 LEUnn 169 ILEnn 175 -1 N SERnn 174 O TYRnn 183 SHEET 3 AJ7 5 METnn 158 GLNnn 163 -1 N ARGnn 162 O GLUnn 170 SHEET 4 AJ7 5 ALAnn 216 LYSnn 222 -1 O TYRnn 219 N VALnn 161 SHEET 5 AJ7 5 TYRnn 237 TRPnn 238 -1 O TYRnn 237 N LYSnn 222 SHEET 1 AJ8 5 THRnn 182 TYRnn 184 0 SHEET 2 AJ8 5 LEUnn 169 ILEnn 175 -1 N SERnn 174 O TYRnn 183 SHEET 3 AJ8 5 METnn 158 GLNnn 163 -1 N ARGnn 162 O GLUnn 170 SHEET 4 AJ8 5 ALAnn 216 LYSnn 222 -1 O TYRnn 219 N VALnn 161 SHEET 5 AJ8 5 THRnn 242 VALnn 244 -1 O THRnn 242 N TYRnn 218 SHEET 1 AJ9 5 SERoo 12 VALoo 15 0 SHEET 2 AJ9 5 THRoo 107 VALoo 111 1 O ARGoo 108 N VALoo 13 SHEET 3 AJ9 5 ALAoo 86 TRPoo 93 -1 N ALAoo 86 O VALoo 109 SHEET 4 AJ9 5 HISoo 36 HISoo 40 -1 N HISoo 40 O ASPoo 87 SHEET 5 AJ9 5 VALoo 47 ILEoo 50 -1 O VALoo 47 N GLNoo 39 SHEET 1 AK1 4 SERoo 12 VALoo 15 0 SHEET 2 AK1 4 THRoo 107 VALoo 111 1 O ARGoo 108 N VALoo 13 SHEET 3 AK1 4 ALAoo 86 TRPoo 93 -1 N ALAoo 86 O VALoo 109 SHEET 4 AK1 4 TYRoo 101 PHEoo 103 -1 O VALoo 102 N VALoo 92 SHEET 1 AK2 3 ALAoo 21 GLYoo 26 0 SHEET 2 AK2 3 THRoo 72 ILEoo 77 -1 O ILEoo 77 N ALAoo 21 SHEET 3 AK2 3 VALoo 64 TYRoo 69 -1 N SERoo 65 O THRoo 76 SHEET 1 AK3 4 GLNoo 127 SERoo 131 0 SHEET 2 AK3 4 LEUoo 142 SERoo 149 -1 O ALAoo 147 N VALoo 129 SHEET 3 AK3 4 THRoo 202 METoo 207 -1 O METoo 207 N LEUoo 142 SHEET 4 AK3 4 PHEoo 192 ASPoo 197 -1 N ASPoo 197 O THRoo 202 SHEET 1 AK4 5 THRoo 182 TYRoo 184 0 SHEET 2 AK4 5 LEUoo 169 ILEoo 175 -1 N SERoo 174 O TYRoo 183 SHEET 3 AK4 5 METoo 158 GLNoo 163 -1 N ARGoo 162 O GLUoo 170 SHEET 4 AK4 5 ALAoo 216 LYSoo 222 -1 O TYRoo 219 N VALoo 161 SHEET 5 AK4 5 TYRoo 237 TRPoo 238 -1 O TYRoo 237 N LYSoo 222 SHEET 1 AK5 5 THRoo 182 TYRoo 184 0 SHEET 2 AK5 5 LEUoo 169 ILEoo 175 -1 N SERoo 174 O TYRoo 183 SHEET 3 AK5 5 METoo 158 GLNoo 163 -1 N ARGoo 162 O GLUoo 170 SHEET 4 AK5 5 ALAoo 216 LYSoo 222 -1 O TYRoo 219 N VALoo 161 SHEET 5 AK5 5 THRoo 242 VALoo 244 -1 O THRoo 242 N TYRoo 218 SHEET 1 AK6 5 SERpp 12 VALpp 15 0 SHEET 2 AK6 5 THRpp 107 VALpp 111 1 O ARGpp 108 N VALpp 13 SHEET 3 AK6 5 ALApp 86 TRPpp 93 -1 N ALApp 86 O VALpp 109 SHEET 4 AK6 5 HISpp 36 HISpp 40 -1 N HISpp 40 O ASPpp 87 SHEET 5 AK6 5 VALpp 47 ILEpp 50 -1 O VALpp 47 N GLNpp 39 SHEET 1 AK7 4 SERpp 12 VALpp 15 0 SHEET 2 AK7 4 THRpp 107 VALpp 111 1 O ARGpp 108 N VALpp 13 SHEET 3 AK7 4 ALApp 86 TRPpp 93 -1 N ALApp 86 O VALpp 109 SHEET 4 AK7 4 TYRpp 101 PHEpp 103 -1 O VALpp 102 N VALpp 92 SHEET 1 AK8 3 ALApp 21 GLYpp 26 0 SHEET 2 AK8 3 THRpp 72 ILEpp 77 -1 O ILEpp 77 N ALApp 21 SHEET 3 AK8 3 VALpp 64 TYRpp 69 -1 N SERpp 65 O THRpp 76 SHEET 1 AK9 4 GLNpp 127 SERpp 131 0 SHEET 2 AK9 4 LEUpp 142 SERpp 149 -1 O ALApp 147 N VALpp 129 SHEET 3 AK9 4 THRpp 202 METpp 207 -1 O LEUpp 205 N LEUpp 144 SHEET 4 AK9 4 PHEpp 192 ASPpp 197 -1 N ASPpp 197 O THRpp 202 SHEET 1 AL1 5 THRpp 182 TYRpp 184 0 SHEET 2 AL1 5 LEUpp 169 ILEpp 175 -1 N SERpp 174 O TYRpp 183 SHEET 3 AL1 5 METpp 158 GLNpp 163 -1 N ARGpp 162 O GLUpp 170 SHEET 4 AL1 5 ALApp 216 LYSpp 222 -1 O TYRpp 219 N VALpp 161 SHEET 5 AL1 5 TYRpp 237 TRPpp 238 -1 O TYRpp 237 N LYSpp 222 SHEET 1 AL2 5 THRpp 182 TYRpp 184 0 SHEET 2 AL2 5 LEUpp 169 ILEpp 175 -1 N SERpp 174 O TYRpp 183 SHEET 3 AL2 5 METpp 158 GLNpp 163 -1 N ARGpp 162 O GLUpp 170 SHEET 4 AL2 5 ALApp 216 LYSpp 222 -1 O TYRpp 219 N VALpp 161 SHEET 5 AL2 5 THRpp 242 VALpp 244 -1 O THRpp 242 N TYRpp 218 SHEET 1 AL3 5 SERqq 12 VALqq 15 0 SHEET 2 AL3 5 THRqq 107 VALqq 111 1 O ARGqq 108 N VALqq 13 SHEET 3 AL3 5 ALAqq 86 TRPqq 93 -1 N ALAqq 86 O VALqq 109 SHEET 4 AL3 5 HISqq 36 HISqq 40 -1 N HISqq 40 O ASPqq 87 SHEET 5 AL3 5 VALqq 47 ILEqq 50 -1 O VALqq 47 N GLNqq 39 SHEET 1 AL4 4 SERqq 12 VALqq 15 0 SHEET 2 AL4 4 THRqq 107 VALqq 111 1 O ARGqq 108 N VALqq 13 SHEET 3 AL4 4 ALAqq 86 TRPqq 93 -1 N ALAqq 86 O VALqq 109 SHEET 4 AL4 4 TYRqq 101 PHEqq 103 -1 O VALqq 102 N VALqq 92 SHEET 1 AL5 3 ALAqq 21 GLYqq 26 0 SHEET 2 AL5 3 THRqq 72 ILEqq 77 -1 O ILEqq 77 N ALAqq 21 SHEET 3 AL5 3 VALqq 64 TYRqq 69 -1 N SERqq 65 O THRqq 76 SHEET 1 AL6 4 GLNqq 127 SERqq 131 0 SHEET 2 AL6 4 LEUqq 142 SERqq 149 -1 O ALAqq 147 N VALqq 129 SHEET 3 AL6 4 THRqq 202 METqq 207 -1 O METqq 207 N LEUqq 142 SHEET 4 AL6 4 PHEqq 192 ASPqq 197 -1 N ASPqq 197 O THRqq 202 SHEET 1 AL7 6 LEUqq 135 VALqq 136 0 SHEET 2 AL7 6 THRqq 242 VALqq 246 1 O THRqq 245 N VALqq 136 SHEET 3 AL7 6 ALAqq 216 LYSqq 222 -1 N TYRqq 218 O THRqq 242 SHEET 4 AL7 6 METqq 158 GLNqq 163 -1 N VALqq 161 O TYRqq 219 SHEET 5 AL7 6 LEUqq 169 ILEqq 175 -1 O GLUqq 170 N ARGqq 162 SHEET 6 AL7 6 THRqq 182 TYRqq 184 -1 O TYRqq 183 N SERqq 174 SHEET 1 AL8 4 LEUqq 135 VALqq 136 0 SHEET 2 AL8 4 THRqq 242 VALqq 246 1 O THRqq 245 N VALqq 136 SHEET 3 AL8 4 ALAqq 216 LYSqq 222 -1 N TYRqq 218 O THRqq 242 SHEET 4 AL8 4 TYRqq 237 TRPqq 238 -1 O TYRqq 237 N LYSqq 222 SSBOND 1 CYSee 25 CYSee 90 1555 1555 2.07 SSBOND 2 CYSee 146 CYSee 220 1555 1555 2.11 SSBOND 3 CYSaa 25 CYSaa 90 1555 1555 2.07 SSBOND 4 CYSaa 146 CYSaa 220 1555 1555 2.11 SSBOND 5 CYSbb 25 CYSbb 90 1555 1555 2.06 SSBOND 6 CYSbb 146 CYSbb 220 1555 1555 2.11 SSBOND 7 CYScc 25 CYScc 90 1555 1555 2.05 SSBOND 8 CYScc 146 CYScc 220 1555 1555 2.08 SSBOND 9 CYSdd 25 CYSdd 90 1555 1555 2.06 SSBOND 10 CYSdd 146 CYSdd 220 1555 1555 2.09 SSBOND 11 CYSmm 25 CYSmm 90 1555 1555 2.06 SSBOND 12 CYSmm 146 CYSmm 220 1555 1555 2.10 SSBOND 13 CYSnn 25 CYSnn 90 1555 1555 2.06 SSBOND 14 CYSnn 146 CYSnn 220 1555 1555 2.08 SSBOND 15 CYSoo 25 CYSoo 90 1555 1555 2.06 SSBOND 16 CYSoo 146 CYSoo 220 1555 1555 2.12 SSBOND 17 CYSpp 25 CYSpp 90 1555 1555 2.06 SSBOND 18 CYSpp 146 CYSpp 220 1555 1555 2.10 SSBOND 19 CYSqq 25 CYSqq 90 1555 1555 2.07 SSBOND 20 CYSqq 146 CYSqq 220 1555 1555 2.10 CRYST1 114.588 114.614 142.373 92.32 106.00 111.41 P 1 10 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.008727 0.003421 0.003079 0.00000 SCALE2 0.000000 0.009371 0.001495 0.00000 SCALE3 0.000000 0.000000 0.007399 0.00000