HEADER VIRAL PROTEIN 29-JUL-21 7PA8 TITLE JC POLYOMAVIRUS VP1 IN COMPLEX WITH FAB 27C2 COMPND MOL_ID: 1; COMPND 2 MOLECULE: MAJOR CAPSID PROTEIN VP1; COMPND 3 CHAIN: AAA, BBB, CCC, DDD, EEE; COMPND 4 FRAGMENT: UNP RESIDUES 23-290; COMPND 5 SYNONYM: MAJOR STRUCTURAL PROTEIN VP1; COMPND 6 ENGINEERED: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: FAB 27C2 LIGHT CHAIN; COMPND 9 CHAIN: FFF, GGG, III, KKK, MMM; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: FAB 27C2 HEAVY CHAIN; COMPND 13 CHAIN: HHH, JJJ, LLL, NNN, YYY; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: JC POLYOMAVIRUS; SOURCE 3 ORGANISM_COMMON: JCPYV; SOURCE 4 ORGANISM_TAXID: 10632; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS ANTIBODY, POLYOMAVIRUS, VP1, NEUTRALIZATION, VIRAL PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR L.J.STROEH,C.HARPRECHT,J.FREYTAG,T.STEHLE JRNL AUTH C.HARPRECHT,L.J.STROEH,L.SENN,B.A.O'HARA,F.NAGEL,J.FREYTAG, JRNL AUTH 2 Y.D.STIEHROF,W.J.ATWOOD,B.COMBALUZIER,T.STEHLE JRNL TITL STRUCTURAL CHARACTERIZATION OF HUMAN NEUTRALIZING ANTIBODIES JRNL TITL 2 AGAINST JC AND BK POLYOMAVIRUS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.15 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0258 REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, REMARK 3 : NICHOLLS,WINN,LONG,VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : NULL REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.15 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 49.01 REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 99.7 REMARK 3 NUMBER OF REFLECTIONS : 81570 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : FREE R-VALUE REMARK 3 FREE R VALUE TEST SET SELECTION : NULL REMARK 3 R VALUE (WORKING + TEST SET) : NULL REMARK 3 R VALUE (WORKING SET) : 0.212 REMARK 3 FREE R VALUE : 0.241 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.001 REMARK 3 FREE R VALUE TEST SET COUNT : 4079 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 3.15 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 3.23 REMARK 3 REFLECTION IN BIN (WORKING SET) : 5475 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 96.31 REMARK 3 BIN R VALUE (WORKING SET) : 0.3300 REMARK 3 BIN FREE R VALUE SET COUNT : 288 REMARK 3 BIN FREE R VALUE : 0.3500 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 21266 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 0 REMARK 3 SOLVENT ATOMS : 0 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 45.46 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : 6.32600 REMARK 3 B22 (A**2) : -2.02300 REMARK 3 B33 (A**2) : -4.31300 REMARK 3 B12 (A**2) : 0.00000 REMARK 3 B13 (A**2) : 0.32500 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): NULL REMARK 3 ESU BASED ON FREE R VALUE (A): 0.405 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): NULL REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.903 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.872 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 21774 ; 0.009 ; 0.013 REMARK 3 BOND LENGTHS OTHERS (A): 19268 ; 0.037 ; 0.017 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 29671 ; 1.604 ; 1.642 REMARK 3 BOND ANGLES OTHERS (DEGREES): 44756 ; 2.444 ; 1.569 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 2803 ; 7.859 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 965 ;33.411 ;22.653 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 3202 ;15.348 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 104 ;17.891 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 2872 ; 0.069 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 24617 ; 0.007 ; 0.020 REMARK 3 GENERAL PLANES OTHERS (A): 4507 ; 0.008 ; 0.020 REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): 3734 ; 0.207 ; 0.200 REMARK 3 NON-BONDED CONTACTS OTHERS (A): 30 ; 0.293 ; 0.200 REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): 10335 ; 0.168 ; 0.200 REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): 401 ; 0.154 ; 0.200 REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 11341 ; 4.689 ; 5.036 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 11340 ; 4.689 ; 5.036 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 14101 ; 7.403 ; 7.525 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): 14102 ; 7.403 ; 7.525 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 10433 ; 4.628 ; 4.923 REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): 10434 ; 4.628 ; 4.924 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 15570 ; 7.285 ; 7.379 REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): 15571 ; 7.285 ; 7.379 REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK BULK SOLVENT REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THEIR REMARK 3 RIDING POSITIONS REMARK 4 REMARK 4 7PA8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE. REMARK 100 THE DEPOSITION ID IS D_1292115683. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 14-FEB-16 REMARK 200 TEMPERATURE (KELVIN) : 93 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SLS REMARK 200 BEAMLINE : X06DA REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.99 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS 2M-F REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : XDS REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 81593 REMARK 200 RESOLUTION RANGE HIGH (A) : 3.150 REMARK 200 RESOLUTION RANGE LOW (A) : 49.007 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.6 REMARK 200 DATA REDUNDANCY : 7.030 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 9.4900 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.15 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.34 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 1.600 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: 3NXG, 5BVJ REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 63.64 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.38 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M AMMONIUM CITRATE TRIBASIC PH REMARK 280 7.0, 12% (W/V) PEG 3350, VAPOR DIFFUSION, SITTING DROP, REMARK 280 TEMPERATURE 277.15K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 55.22000 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: AAA, BBB, CCC, DDD, EEE, FFF, REMARK 350 AND CHAINS: GGG, HHH, III, JJJ, KKK, REMARK 350 AND CHAINS: LLL, MMM, NNN, YYY REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLY A 18 REMARK 465 SER A 19 REMARK 465 HIS A 20 REMARK 465 MET A 21 REMARK 465 GLY A 22 REMARK 465 GLY A 23 REMARK 465 GLU A 92 REMARK 465 ASP A 93 REMARK 465 LEU A 94 REMARK 465 THR A 95 REMARK 465 CYS A 96 REMARK 465 GLY A 97 REMARK 465 GLY B 18 REMARK 465 SER B 19 REMARK 465 HIS B 20 REMARK 465 MET B 21 REMARK 465 GLY B 22 REMARK 465 GLY B 23 REMARK 465 GLU B 92 REMARK 465 ASP B 93 REMARK 465 LEU B 94 REMARK 465 THR B 95 REMARK 465 CYS B 96 REMARK 465 GLY B 97 REMARK 465 ASN B 98 REMARK 465 ASN B 289 REMARK 465 GLY C 18 REMARK 465 SER C 19 REMARK 465 HIS C 20 REMARK 465 MET C 21 REMARK 465 GLY C 22 REMARK 465 GLY C 23 REMARK 465 VAL C 24 REMARK 465 ASN C 91 REMARK 465 GLU C 92 REMARK 465 ASP C 93 REMARK 465 LEU C 94 REMARK 465 THR C 95 REMARK 465 CYS C 96 REMARK 465 GLY C 97 REMARK 465 ASN C 98 REMARK 465 GLY D 18 REMARK 465 SER D 19 REMARK 465 HIS D 20 REMARK 465 MET D 21 REMARK 465 GLY D 22 REMARK 465 GLY D 23 REMARK 465 GLU D 92 REMARK 465 ASP D 93 REMARK 465 LEU D 94 REMARK 465 THR D 95 REMARK 465 CYS D 96 REMARK 465 GLY E 18 REMARK 465 SER E 19 REMARK 465 HIS E 20 REMARK 465 GLU E 92 REMARK 465 ASP E 93 REMARK 465 LEU E 94 REMARK 465 THR E 95 REMARK 465 CYS E 96 REMARK 465 GLY E 97 REMARK 465 ASN E 98 REMARK 465 GLN F 1 REMARK 465 GLU F 127 REMARK 465 GLU F 128 REMARK 465 LEU F 129 REMARK 465 GLN F 130 REMARK 465 ALA F 131 REMARK 465 LYS F 153 REMARK 465 ALA F 154 REMARK 465 ASP F 155 REMARK 465 GLY F 156 REMARK 465 SER F 157 REMARK 465 PRO F 158 REMARK 465 VAL F 159 REMARK 465 LYS F 160 REMARK 465 GLU F 187 REMARK 465 GLN F 188 REMARK 465 TRP F 189 REMARK 465 LYS F 190 REMARK 465 SER F 191 REMARK 465 HIS F 192 REMARK 465 ARG F 193 REMARK 465 GLN G 1 REMARK 465 SER G 2 REMARK 465 VAL G 3 REMARK 465 SER G 125 REMARK 465 SER G 126 REMARK 465 GLU G 127 REMARK 465 GLU G 128 REMARK 465 LEU G 129 REMARK 465 GLN G 130 REMARK 465 ALA G 131 REMARK 465 ASN G 132 REMARK 465 LYS G 133 REMARK 465 VAL G 150 REMARK 465 ALA G 151 REMARK 465 TRP G 152 REMARK 465 LYS G 153 REMARK 465 ALA G 154 REMARK 465 ASP G 155 REMARK 465 GLY G 156 REMARK 465 SER G 157 REMARK 465 PRO G 158 REMARK 465 VAL G 159 REMARK 465 LYS G 160 REMARK 465 ALA G 161 REMARK 465 SER G 183 REMARK 465 LEU G 184 REMARK 465 THR G 185 REMARK 465 PRO G 186 REMARK 465 GLU G 187 REMARK 465 GLN G 188 REMARK 465 TRP G 189 REMARK 465 LYS G 190 REMARK 465 SER G 191 REMARK 465 HIS G 192 REMARK 465 ARG G 193 REMARK 465 SER G 194 REMARK 465 PHE H 132 REMARK 465 PRO H 133 REMARK 465 LEU H 134 REMARK 465 ALA H 135 REMARK 465 PRO H 136 REMARK 465 SER H 137 REMARK 465 SER H 138 REMARK 465 LYS H 139 REMARK 465 SER H 140 REMARK 465 THR H 141 REMARK 465 SER H 142 REMARK 465 GLY H 143 REMARK 465 GLY H 144 REMARK 465 THR H 145 REMARK 465 ALA H 146 REMARK 465 ALA H 147 REMARK 465 LEU H 148 REMARK 465 GLY H 149 REMARK 465 CYS H 150 REMARK 465 LEU H 151 REMARK 465 VAL H 160 REMARK 465 THR H 161 REMARK 465 VAL H 162 REMARK 465 SER H 163 REMARK 465 TRP H 164 REMARK 465 ASN H 165 REMARK 465 SER H 166 REMARK 465 GLY H 167 REMARK 465 ALA H 168 REMARK 465 LEU H 169 REMARK 465 THR H 170 REMARK 465 SER H 171 REMARK 465 GLY H 172 REMARK 465 VAL H 173 REMARK 465 HIS H 174 REMARK 465 SER H 190 REMARK 465 VAL H 191 REMARK 465 VAL H 192 REMARK 465 THR H 193 REMARK 465 VAL H 194 REMARK 465 PRO H 195 REMARK 465 SER H 196 REMARK 465 SER H 197 REMARK 465 SER H 198 REMARK 465 LEU H 199 REMARK 465 GLY H 200 REMARK 465 THR H 201 REMARK 465 GLN H 202 REMARK 465 THR H 203 REMARK 465 TYR H 204 REMARK 465 ILE H 205 REMARK 465 CYS H 206 REMARK 465 ASN H 207 REMARK 465 VAL H 208 REMARK 465 ASN H 209 REMARK 465 HIS H 210 REMARK 465 LYS H 211 REMARK 465 PRO H 212 REMARK 465 SER H 213 REMARK 465 ASN H 214 REMARK 465 THR H 215 REMARK 465 LYS H 216 REMARK 465 VAL H 217 REMARK 465 ASP H 218 REMARK 465 LYS H 219 REMARK 465 LYS H 220 REMARK 465 VAL H 221 REMARK 465 GLU H 222 REMARK 465 PRO H 223 REMARK 465 LYS H 224 REMARK 465 SER H 225 REMARK 465 CYS H 226 REMARK 465 ASP H 227 REMARK 465 LYS H 228 REMARK 465 THR H 229 REMARK 465 HIS H 230 REMARK 465 THR H 231 REMARK 465 CYS H 232 REMARK 465 PRO H 233 REMARK 465 PRO H 234 REMARK 465 CYS H 235 REMARK 465 PRO H 236 REMARK 465 ALA H 237 REMARK 465 PRO H 238 REMARK 465 GLU H 239 REMARK 465 LEU H 240 REMARK 465 LEU H 241 REMARK 465 GLY H 242 REMARK 465 GLY H 243 REMARK 465 PRO H 244 REMARK 465 SER H 245 REMARK 465 VAL H 246 REMARK 465 PHE H 247 REMARK 465 LEU H 248 REMARK 465 PHE H 249 REMARK 465 PRO H 250 REMARK 465 PRO H 251 REMARK 465 LYS H 252 REMARK 465 PRO H 253 REMARK 465 LYS H 254 REMARK 465 ASP H 255 REMARK 465 THR H 256 REMARK 465 LEU H 257 REMARK 465 MET H 258 REMARK 465 ILE H 259 REMARK 465 SER H 260 REMARK 465 ARG H 261 REMARK 465 THR H 262 REMARK 465 PRO H 263 REMARK 465 GLU H 264 REMARK 465 VAL H 265 REMARK 465 THR H 266 REMARK 465 CYS H 267 REMARK 465 VAL H 268 REMARK 465 VAL H 269 REMARK 465 VAL H 270 REMARK 465 ASP H 271 REMARK 465 VAL H 272 REMARK 465 SER H 273 REMARK 465 HIS H 274 REMARK 465 GLU H 275 REMARK 465 ASP H 276 REMARK 465 PRO H 277 REMARK 465 GLU H 278 REMARK 465 VAL H 279 REMARK 465 LYS H 280 REMARK 465 PHE H 281 REMARK 465 ASN H 282 REMARK 465 TRP H 283 REMARK 465 TYR H 284 REMARK 465 VAL H 285 REMARK 465 ASP H 286 REMARK 465 GLY H 287 REMARK 465 VAL H 288 REMARK 465 GLU H 289 REMARK 465 VAL H 290 REMARK 465 HIS H 291 REMARK 465 ASN H 292 REMARK 465 ALA H 293 REMARK 465 LYS H 294 REMARK 465 THR H 295 REMARK 465 LYS H 296 REMARK 465 PRO H 297 REMARK 465 ARG H 298 REMARK 465 GLU H 299 REMARK 465 GLU H 300 REMARK 465 GLN H 301 REMARK 465 TYR H 302 REMARK 465 ASN H 303 REMARK 465 SER H 304 REMARK 465 THR H 305 REMARK 465 TYR H 306 REMARK 465 ARG H 307 REMARK 465 VAL H 308 REMARK 465 VAL H 309 REMARK 465 SER H 310 REMARK 465 VAL H 311 REMARK 465 LEU H 312 REMARK 465 THR H 313 REMARK 465 VAL H 314 REMARK 465 LEU H 315 REMARK 465 HIS H 316 REMARK 465 GLN H 317 REMARK 465 ASP H 318 REMARK 465 TRP H 319 REMARK 465 LEU H 320 REMARK 465 ASN H 321 REMARK 465 GLY H 322 REMARK 465 LYS H 323 REMARK 465 GLU H 324 REMARK 465 TYR H 325 REMARK 465 LYS H 326 REMARK 465 CYS H 327 REMARK 465 LYS H 328 REMARK 465 VAL H 329 REMARK 465 SER H 330 REMARK 465 ASN H 331 REMARK 465 LYS H 332 REMARK 465 ALA H 333 REMARK 465 LEU H 334 REMARK 465 PRO H 335 REMARK 465 ALA H 336 REMARK 465 PRO H 337 REMARK 465 ILE H 338 REMARK 465 GLU H 339 REMARK 465 LYS H 340 REMARK 465 THR H 341 REMARK 465 ILE H 342 REMARK 465 SER H 343 REMARK 465 LYS H 344 REMARK 465 ALA H 345 REMARK 465 LYS H 346 REMARK 465 GLY H 347 REMARK 465 GLN H 348 REMARK 465 PRO H 349 REMARK 465 ARG H 350 REMARK 465 GLU H 351 REMARK 465 PRO H 352 REMARK 465 GLN H 353 REMARK 465 VAL H 354 REMARK 465 TYR H 355 REMARK 465 THR H 356 REMARK 465 LEU H 357 REMARK 465 PRO H 358 REMARK 465 PRO H 359 REMARK 465 SER H 360 REMARK 465 ARG H 361 REMARK 465 ASP H 362 REMARK 465 GLU H 363 REMARK 465 LEU H 364 REMARK 465 THR H 365 REMARK 465 LYS H 366 REMARK 465 ASN H 367 REMARK 465 GLN H 368 REMARK 465 VAL H 369 REMARK 465 SER H 370 REMARK 465 LEU H 371 REMARK 465 THR H 372 REMARK 465 CYS H 373 REMARK 465 LEU H 374 REMARK 465 VAL H 375 REMARK 465 LYS H 376 REMARK 465 GLY H 377 REMARK 465 PHE H 378 REMARK 465 TYR H 379 REMARK 465 PRO H 380 REMARK 465 SER H 381 REMARK 465 ASP H 382 REMARK 465 ILE H 383 REMARK 465 ALA H 384 REMARK 465 VAL H 385 REMARK 465 GLU H 386 REMARK 465 TRP H 387 REMARK 465 GLU H 388 REMARK 465 SER H 389 REMARK 465 ASN H 390 REMARK 465 GLY H 391 REMARK 465 GLN H 392 REMARK 465 PRO H 393 REMARK 465 GLU H 394 REMARK 465 ASN H 395 REMARK 465 ASN H 396 REMARK 465 TYR H 397 REMARK 465 LYS H 398 REMARK 465 THR H 399 REMARK 465 THR H 400 REMARK 465 PRO H 401 REMARK 465 PRO H 402 REMARK 465 VAL H 403 REMARK 465 GLN I 1 REMARK 465 LYS I 114 REMARK 465 ALA I 115 REMARK 465 ASN I 116 REMARK 465 PRO I 117 REMARK 465 THR I 118 REMARK 465 VAL I 119 REMARK 465 THR I 120 REMARK 465 LEU I 121 REMARK 465 PHE I 122 REMARK 465 PRO I 123 REMARK 465 PRO I 124 REMARK 465 SER I 125 REMARK 465 SER I 126 REMARK 465 GLU I 127 REMARK 465 GLU I 128 REMARK 465 LEU I 129 REMARK 465 GLN I 130 REMARK 465 ALA I 131 REMARK 465 ILE I 140 REMARK 465 SER I 141 REMARK 465 ASP I 142 REMARK 465 PHE I 143 REMARK 465 TYR I 144 REMARK 465 PRO I 145 REMARK 465 GLY I 146 REMARK 465 ALA I 147 REMARK 465 VAL I 148 REMARK 465 THR I 149 REMARK 465 VAL I 150 REMARK 465 ALA I 151 REMARK 465 TRP I 152 REMARK 465 LYS I 153 REMARK 465 ALA I 154 REMARK 465 ASP I 155 REMARK 465 GLY I 156 REMARK 465 SER I 157 REMARK 465 PRO I 158 REMARK 465 VAL I 159 REMARK 465 LYS I 160 REMARK 465 ALA I 161 REMARK 465 GLY I 162 REMARK 465 LYS I 170 REMARK 465 GLN I 171 REMARK 465 SER I 172 REMARK 465 ASN I 173 REMARK 465 ASN I 174 REMARK 465 LYS I 175 REMARK 465 THR I 176 REMARK 465 ALA I 177 REMARK 465 GLU I 187 REMARK 465 GLN I 188 REMARK 465 TRP I 189 REMARK 465 LYS I 190 REMARK 465 SER I 191 REMARK 465 HIS I 192 REMARK 465 ARG I 193 REMARK 465 SER I 194 REMARK 465 TYR I 195 REMARK 465 SER I 196 REMARK 465 CYS I 197 REMARK 465 GLN I 198 REMARK 465 VAL I 199 REMARK 465 THR I 200 REMARK 465 HIS I 201 REMARK 465 GLU I 202 REMARK 465 GLY I 203 REMARK 465 THR I 204 REMARK 465 THR I 205 REMARK 465 VAL I 206 REMARK 465 GLU I 207 REMARK 465 LYS I 208 REMARK 465 THR I 209 REMARK 465 VAL I 210 REMARK 465 ALA I 211 REMARK 465 PRO I 212 REMARK 465 PRO J 133 REMARK 465 LEU J 134 REMARK 465 ALA J 135 REMARK 465 PRO J 136 REMARK 465 SER J 137 REMARK 465 SER J 138 REMARK 465 LYS J 139 REMARK 465 SER J 140 REMARK 465 THR J 141 REMARK 465 SER J 142 REMARK 465 GLY J 143 REMARK 465 GLY J 144 REMARK 465 THR J 145 REMARK 465 ALA J 146 REMARK 465 SER J 166 REMARK 465 GLY J 167 REMARK 465 ALA J 168 REMARK 465 LEU J 169 REMARK 465 THR J 170 REMARK 465 SER J 171 REMARK 465 GLY J 172 REMARK 465 VAL J 173 REMARK 465 HIS J 174 REMARK 465 VAL J 192 REMARK 465 THR J 193 REMARK 465 VAL J 194 REMARK 465 PRO J 195 REMARK 465 SER J 196 REMARK 465 SER J 197 REMARK 465 SER J 198 REMARK 465 LEU J 199 REMARK 465 GLY J 200 REMARK 465 THR J 201 REMARK 465 GLN J 202 REMARK 465 THR J 203 REMARK 465 TYR J 204 REMARK 465 ILE J 205 REMARK 465 LYS J 220 REMARK 465 VAL J 221 REMARK 465 GLU J 222 REMARK 465 PRO J 223 REMARK 465 LYS J 224 REMARK 465 SER J 225 REMARK 465 CYS J 226 REMARK 465 ASP J 227 REMARK 465 LYS J 228 REMARK 465 THR J 229 REMARK 465 HIS J 230 REMARK 465 THR J 231 REMARK 465 CYS J 232 REMARK 465 PRO J 233 REMARK 465 PRO J 234 REMARK 465 CYS J 235 REMARK 465 PRO J 236 REMARK 465 ALA J 237 REMARK 465 PRO J 238 REMARK 465 GLU J 239 REMARK 465 LEU J 240 REMARK 465 LEU J 241 REMARK 465 GLY J 242 REMARK 465 GLY J 243 REMARK 465 PRO J 244 REMARK 465 SER J 245 REMARK 465 VAL J 246 REMARK 465 PHE J 247 REMARK 465 LEU J 248 REMARK 465 PHE J 249 REMARK 465 PRO J 250 REMARK 465 PRO J 251 REMARK 465 LYS J 252 REMARK 465 PRO J 253 REMARK 465 LYS J 254 REMARK 465 ASP J 255 REMARK 465 THR J 256 REMARK 465 LEU J 257 REMARK 465 MET J 258 REMARK 465 ILE J 259 REMARK 465 SER J 260 REMARK 465 ARG J 261 REMARK 465 THR J 262 REMARK 465 PRO J 263 REMARK 465 GLU J 264 REMARK 465 VAL J 265 REMARK 465 THR J 266 REMARK 465 CYS J 267 REMARK 465 VAL J 268 REMARK 465 VAL J 269 REMARK 465 VAL J 270 REMARK 465 ASP J 271 REMARK 465 VAL J 272 REMARK 465 SER J 273 REMARK 465 HIS J 274 REMARK 465 GLU J 275 REMARK 465 ASP J 276 REMARK 465 PRO J 277 REMARK 465 GLU J 278 REMARK 465 VAL J 279 REMARK 465 LYS J 280 REMARK 465 PHE J 281 REMARK 465 ASN J 282 REMARK 465 TRP J 283 REMARK 465 TYR J 284 REMARK 465 VAL J 285 REMARK 465 ASP J 286 REMARK 465 GLY J 287 REMARK 465 VAL J 288 REMARK 465 GLU J 289 REMARK 465 VAL J 290 REMARK 465 HIS J 291 REMARK 465 ASN J 292 REMARK 465 ALA J 293 REMARK 465 LYS J 294 REMARK 465 THR J 295 REMARK 465 LYS J 296 REMARK 465 PRO J 297 REMARK 465 ARG J 298 REMARK 465 GLU J 299 REMARK 465 GLU J 300 REMARK 465 GLN J 301 REMARK 465 TYR J 302 REMARK 465 ASN J 303 REMARK 465 SER J 304 REMARK 465 THR J 305 REMARK 465 TYR J 306 REMARK 465 ARG J 307 REMARK 465 VAL J 308 REMARK 465 VAL J 309 REMARK 465 SER J 310 REMARK 465 VAL J 311 REMARK 465 LEU J 312 REMARK 465 THR J 313 REMARK 465 VAL J 314 REMARK 465 LEU J 315 REMARK 465 HIS J 316 REMARK 465 GLN J 317 REMARK 465 ASP J 318 REMARK 465 TRP J 319 REMARK 465 LEU J 320 REMARK 465 ASN J 321 REMARK 465 GLY J 322 REMARK 465 LYS J 323 REMARK 465 GLU J 324 REMARK 465 TYR J 325 REMARK 465 LYS J 326 REMARK 465 CYS J 327 REMARK 465 LYS J 328 REMARK 465 VAL J 329 REMARK 465 SER J 330 REMARK 465 ASN J 331 REMARK 465 LYS J 332 REMARK 465 ALA J 333 REMARK 465 LEU J 334 REMARK 465 PRO J 335 REMARK 465 ALA J 336 REMARK 465 PRO J 337 REMARK 465 ILE J 338 REMARK 465 GLU J 339 REMARK 465 LYS J 340 REMARK 465 THR J 341 REMARK 465 ILE J 342 REMARK 465 SER J 343 REMARK 465 LYS J 344 REMARK 465 ALA J 345 REMARK 465 LYS J 346 REMARK 465 GLY J 347 REMARK 465 GLN J 348 REMARK 465 PRO J 349 REMARK 465 ARG J 350 REMARK 465 GLU J 351 REMARK 465 PRO J 352 REMARK 465 GLN J 353 REMARK 465 VAL J 354 REMARK 465 TYR J 355 REMARK 465 THR J 356 REMARK 465 LEU J 357 REMARK 465 PRO J 358 REMARK 465 PRO J 359 REMARK 465 SER J 360 REMARK 465 ARG J 361 REMARK 465 ASP J 362 REMARK 465 GLU J 363 REMARK 465 LEU J 364 REMARK 465 THR J 365 REMARK 465 LYS J 366 REMARK 465 ASN J 367 REMARK 465 GLN J 368 REMARK 465 VAL J 369 REMARK 465 SER J 370 REMARK 465 LEU J 371 REMARK 465 THR J 372 REMARK 465 CYS J 373 REMARK 465 LEU J 374 REMARK 465 VAL J 375 REMARK 465 LYS J 376 REMARK 465 GLY J 377 REMARK 465 PHE J 378 REMARK 465 TYR J 379 REMARK 465 PRO J 380 REMARK 465 SER J 381 REMARK 465 ASP J 382 REMARK 465 ILE J 383 REMARK 465 ALA J 384 REMARK 465 VAL J 385 REMARK 465 GLU J 386 REMARK 465 TRP J 387 REMARK 465 GLU J 388 REMARK 465 SER J 389 REMARK 465 ASN J 390 REMARK 465 GLY J 391 REMARK 465 GLN J 392 REMARK 465 PRO J 393 REMARK 465 GLU J 394 REMARK 465 ASN J 395 REMARK 465 ASN J 396 REMARK 465 TYR J 397 REMARK 465 LYS J 398 REMARK 465 THR J 399 REMARK 465 THR J 400 REMARK 465 PRO J 401 REMARK 465 PRO J 402 REMARK 465 VAL J 403 REMARK 465 GLN K 1 REMARK 465 LYS K 114 REMARK 465 ALA K 115 REMARK 465 ASN K 116 REMARK 465 PRO K 117 REMARK 465 THR K 118 REMARK 465 VAL K 119 REMARK 465 THR K 120 REMARK 465 LEU K 121 REMARK 465 PHE K 122 REMARK 465 PRO K 123 REMARK 465 PRO K 124 REMARK 465 SER K 125 REMARK 465 SER K 126 REMARK 465 GLU K 127 REMARK 465 GLU K 128 REMARK 465 LEU K 129 REMARK 465 GLN K 130 REMARK 465 ALA K 131 REMARK 465 ASN K 132 REMARK 465 LYS K 133 REMARK 465 ALA K 134 REMARK 465 THR K 135 REMARK 465 LEU K 136 REMARK 465 VAL K 137 REMARK 465 CYS K 138 REMARK 465 THR K 149 REMARK 465 VAL K 150 REMARK 465 ALA K 151 REMARK 465 TRP K 152 REMARK 465 LYS K 153 REMARK 465 ALA K 154 REMARK 465 ASP K 155 REMARK 465 GLY K 156 REMARK 465 SER K 157 REMARK 465 PRO K 158 REMARK 465 VAL K 159 REMARK 465 LYS K 160 REMARK 465 ALA K 161 REMARK 465 GLY K 162 REMARK 465 VAL K 163 REMARK 465 GLU K 164 REMARK 465 GLN K 171 REMARK 465 SER K 172 REMARK 465 ASN K 173 REMARK 465 ASN K 174 REMARK 465 LYS K 175 REMARK 465 THR K 176 REMARK 465 SER K 183 REMARK 465 LEU K 184 REMARK 465 THR K 185 REMARK 465 PRO K 186 REMARK 465 GLU K 187 REMARK 465 GLN K 188 REMARK 465 TRP K 189 REMARK 465 LYS K 190 REMARK 465 SER K 191 REMARK 465 HIS K 192 REMARK 465 ARG K 193 REMARK 465 SER K 194 REMARK 465 TYR K 195 REMARK 465 SER K 196 REMARK 465 CYS K 197 REMARK 465 GLN K 198 REMARK 465 VAL K 199 REMARK 465 THR K 200 REMARK 465 HIS K 201 REMARK 465 GLU K 202 REMARK 465 GLY K 203 REMARK 465 THR K 204 REMARK 465 THR K 205 REMARK 465 VAL K 206 REMARK 465 GLU K 207 REMARK 465 LYS K 208 REMARK 465 THR K 209 REMARK 465 VAL K 210 REMARK 465 ALA K 211 REMARK 465 PRO K 212 REMARK 465 PHE L 132 REMARK 465 PRO L 133 REMARK 465 LEU L 134 REMARK 465 ALA L 135 REMARK 465 PRO L 136 REMARK 465 SER L 137 REMARK 465 SER L 138 REMARK 465 LYS L 139 REMARK 465 SER L 140 REMARK 465 THR L 141 REMARK 465 SER L 142 REMARK 465 GLY L 143 REMARK 465 GLY L 144 REMARK 465 THR L 145 REMARK 465 ALA L 146 REMARK 465 ALA L 147 REMARK 465 LEU L 148 REMARK 465 GLY L 149 REMARK 465 SER L 163 REMARK 465 TRP L 164 REMARK 465 ASN L 165 REMARK 465 SER L 166 REMARK 465 GLY L 167 REMARK 465 ALA L 168 REMARK 465 LEU L 169 REMARK 465 THR L 170 REMARK 465 SER L 171 REMARK 465 GLY L 172 REMARK 465 VAL L 173 REMARK 465 THR L 193 REMARK 465 VAL L 194 REMARK 465 PRO L 195 REMARK 465 SER L 196 REMARK 465 SER L 197 REMARK 465 SER L 198 REMARK 465 LEU L 199 REMARK 465 GLY L 200 REMARK 465 THR L 201 REMARK 465 GLN L 202 REMARK 465 THR L 203 REMARK 465 TYR L 204 REMARK 465 ILE L 205 REMARK 465 CYS L 206 REMARK 465 LYS L 219 REMARK 465 LYS L 220 REMARK 465 VAL L 221 REMARK 465 GLU L 222 REMARK 465 PRO L 223 REMARK 465 LYS L 224 REMARK 465 SER L 225 REMARK 465 CYS L 226 REMARK 465 ASP L 227 REMARK 465 LYS L 228 REMARK 465 THR L 229 REMARK 465 HIS L 230 REMARK 465 THR L 231 REMARK 465 CYS L 232 REMARK 465 PRO L 233 REMARK 465 PRO L 234 REMARK 465 CYS L 235 REMARK 465 PRO L 236 REMARK 465 ALA L 237 REMARK 465 PRO L 238 REMARK 465 GLU L 239 REMARK 465 LEU L 240 REMARK 465 LEU L 241 REMARK 465 GLY L 242 REMARK 465 GLY L 243 REMARK 465 PRO L 244 REMARK 465 SER L 245 REMARK 465 VAL L 246 REMARK 465 PHE L 247 REMARK 465 LEU L 248 REMARK 465 PHE L 249 REMARK 465 PRO L 250 REMARK 465 PRO L 251 REMARK 465 LYS L 252 REMARK 465 PRO L 253 REMARK 465 LYS L 254 REMARK 465 ASP L 255 REMARK 465 THR L 256 REMARK 465 LEU L 257 REMARK 465 MET L 258 REMARK 465 ILE L 259 REMARK 465 SER L 260 REMARK 465 ARG L 261 REMARK 465 THR L 262 REMARK 465 PRO L 263 REMARK 465 GLU L 264 REMARK 465 VAL L 265 REMARK 465 THR L 266 REMARK 465 CYS L 267 REMARK 465 VAL L 268 REMARK 465 VAL L 269 REMARK 465 VAL L 270 REMARK 465 ASP L 271 REMARK 465 VAL L 272 REMARK 465 SER L 273 REMARK 465 HIS L 274 REMARK 465 GLU L 275 REMARK 465 ASP L 276 REMARK 465 PRO L 277 REMARK 465 GLU L 278 REMARK 465 VAL L 279 REMARK 465 LYS L 280 REMARK 465 PHE L 281 REMARK 465 ASN L 282 REMARK 465 TRP L 283 REMARK 465 TYR L 284 REMARK 465 VAL L 285 REMARK 465 ASP L 286 REMARK 465 GLY L 287 REMARK 465 VAL L 288 REMARK 465 GLU L 289 REMARK 465 VAL L 290 REMARK 465 HIS L 291 REMARK 465 ASN L 292 REMARK 465 ALA L 293 REMARK 465 LYS L 294 REMARK 465 THR L 295 REMARK 465 LYS L 296 REMARK 465 PRO L 297 REMARK 465 ARG L 298 REMARK 465 GLU L 299 REMARK 465 GLU L 300 REMARK 465 GLN L 301 REMARK 465 TYR L 302 REMARK 465 ASN L 303 REMARK 465 SER L 304 REMARK 465 THR L 305 REMARK 465 TYR L 306 REMARK 465 ARG L 307 REMARK 465 VAL L 308 REMARK 465 VAL L 309 REMARK 465 SER L 310 REMARK 465 VAL L 311 REMARK 465 LEU L 312 REMARK 465 THR L 313 REMARK 465 VAL L 314 REMARK 465 LEU L 315 REMARK 465 HIS L 316 REMARK 465 GLN L 317 REMARK 465 ASP L 318 REMARK 465 TRP L 319 REMARK 465 LEU L 320 REMARK 465 ASN L 321 REMARK 465 GLY L 322 REMARK 465 LYS L 323 REMARK 465 GLU L 324 REMARK 465 TYR L 325 REMARK 465 LYS L 326 REMARK 465 CYS L 327 REMARK 465 LYS L 328 REMARK 465 VAL L 329 REMARK 465 SER L 330 REMARK 465 ASN L 331 REMARK 465 LYS L 332 REMARK 465 ALA L 333 REMARK 465 LEU L 334 REMARK 465 PRO L 335 REMARK 465 ALA L 336 REMARK 465 PRO L 337 REMARK 465 ILE L 338 REMARK 465 GLU L 339 REMARK 465 LYS L 340 REMARK 465 THR L 341 REMARK 465 ILE L 342 REMARK 465 SER L 343 REMARK 465 LYS L 344 REMARK 465 ALA L 345 REMARK 465 LYS L 346 REMARK 465 GLY L 347 REMARK 465 GLN L 348 REMARK 465 PRO L 349 REMARK 465 ARG L 350 REMARK 465 GLU L 351 REMARK 465 PRO L 352 REMARK 465 GLN L 353 REMARK 465 VAL L 354 REMARK 465 TYR L 355 REMARK 465 THR L 356 REMARK 465 LEU L 357 REMARK 465 PRO L 358 REMARK 465 PRO L 359 REMARK 465 SER L 360 REMARK 465 ARG L 361 REMARK 465 ASP L 362 REMARK 465 GLU L 363 REMARK 465 LEU L 364 REMARK 465 THR L 365 REMARK 465 LYS L 366 REMARK 465 ASN L 367 REMARK 465 GLN L 368 REMARK 465 VAL L 369 REMARK 465 SER L 370 REMARK 465 LEU L 371 REMARK 465 THR L 372 REMARK 465 CYS L 373 REMARK 465 LEU L 374 REMARK 465 VAL L 375 REMARK 465 LYS L 376 REMARK 465 GLY L 377 REMARK 465 PHE L 378 REMARK 465 TYR L 379 REMARK 465 PRO L 380 REMARK 465 SER L 381 REMARK 465 ASP L 382 REMARK 465 ILE L 383 REMARK 465 ALA L 384 REMARK 465 VAL L 385 REMARK 465 GLU L 386 REMARK 465 TRP L 387 REMARK 465 GLU L 388 REMARK 465 SER L 389 REMARK 465 ASN L 390 REMARK 465 GLY L 391 REMARK 465 GLN L 392 REMARK 465 PRO L 393 REMARK 465 GLU L 394 REMARK 465 ASN L 395 REMARK 465 ASN L 396 REMARK 465 TYR L 397 REMARK 465 LYS L 398 REMARK 465 THR L 399 REMARK 465 THR L 400 REMARK 465 PRO L 401 REMARK 465 PRO L 402 REMARK 465 VAL L 403 REMARK 465 GLN M 1 REMARK 465 LEU M 110 REMARK 465 GLY M 111 REMARK 465 ALA M 112 REMARK 465 PRO M 113 REMARK 465 LYS M 114 REMARK 465 ALA M 115 REMARK 465 ASN M 116 REMARK 465 PRO M 117 REMARK 465 THR M 118 REMARK 465 VAL M 119 REMARK 465 THR M 120 REMARK 465 LEU M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 PRO M 124 REMARK 465 SER M 125 REMARK 465 SER M 126 REMARK 465 GLU M 127 REMARK 465 GLU M 128 REMARK 465 LEU M 129 REMARK 465 GLN M 130 REMARK 465 ALA M 131 REMARK 465 ASN M 132 REMARK 465 LYS M 133 REMARK 465 ALA M 134 REMARK 465 THR M 135 REMARK 465 LEU M 136 REMARK 465 VAL M 137 REMARK 465 CYS M 138 REMARK 465 LEU M 139 REMARK 465 ILE M 140 REMARK 465 SER M 141 REMARK 465 ASP M 142 REMARK 465 PHE M 143 REMARK 465 TYR M 144 REMARK 465 PRO M 145 REMARK 465 GLY M 146 REMARK 465 ALA M 147 REMARK 465 VAL M 148 REMARK 465 THR M 149 REMARK 465 VAL M 150 REMARK 465 ALA M 151 REMARK 465 TRP M 152 REMARK 465 LYS M 153 REMARK 465 ALA M 154 REMARK 465 ASP M 155 REMARK 465 GLY M 156 REMARK 465 SER M 157 REMARK 465 PRO M 158 REMARK 465 VAL M 159 REMARK 465 LYS M 160 REMARK 465 ALA M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 GLU M 164 REMARK 465 THR M 165 REMARK 465 THR M 166 REMARK 465 LYS M 167 REMARK 465 PRO M 168 REMARK 465 SER M 169 REMARK 465 LYS M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 ASN M 173 REMARK 465 ASN M 174 REMARK 465 LYS M 175 REMARK 465 THR M 176 REMARK 465 ALA M 177 REMARK 465 ALA M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 TYR M 181 REMARK 465 LEU M 182 REMARK 465 SER M 183 REMARK 465 LEU M 184 REMARK 465 THR M 185 REMARK 465 PRO M 186 REMARK 465 GLU M 187 REMARK 465 GLN M 188 REMARK 465 TRP M 189 REMARK 465 LYS M 190 REMARK 465 SER M 191 REMARK 465 HIS M 192 REMARK 465 ARG M 193 REMARK 465 SER M 194 REMARK 465 TYR M 195 REMARK 465 SER M 196 REMARK 465 CYS M 197 REMARK 465 GLN M 198 REMARK 465 VAL M 199 REMARK 465 THR M 200 REMARK 465 HIS M 201 REMARK 465 GLU M 202 REMARK 465 GLY M 203 REMARK 465 THR M 204 REMARK 465 THR M 205 REMARK 465 VAL M 206 REMARK 465 GLU M 207 REMARK 465 LYS M 208 REMARK 465 THR M 209 REMARK 465 VAL M 210 REMARK 465 ALA M 211 REMARK 465 PRO M 212 REMARK 465 ALA N 119 REMARK 465 SER N 120 REMARK 465 THR N 121 REMARK 465 LYS N 122 REMARK 465 GLY N 123 REMARK 465 PRO N 124 REMARK 465 SER N 125 REMARK 465 VAL N 126 REMARK 465 PHE N 127 REMARK 465 PRO N 128 REMARK 465 LEU N 129 REMARK 465 ALA N 130 REMARK 465 PRO N 131 REMARK 465 SER N 132 REMARK 465 SER N 133 REMARK 465 LYS N 134 REMARK 465 SER N 135 REMARK 465 THR N 136 REMARK 465 SER N 137 REMARK 465 GLY N 138 REMARK 465 GLY N 139 REMARK 465 THR N 140 REMARK 465 ALA N 141 REMARK 465 ALA N 142 REMARK 465 LEU N 143 REMARK 465 GLY N 144 REMARK 465 CYS N 145 REMARK 465 LEU N 146 REMARK 465 VAL N 147 REMARK 465 LYS N 148 REMARK 465 ASP N 149 REMARK 465 TYR N 150 REMARK 465 PHE N 151 REMARK 465 PRO N 152 REMARK 465 GLU N 153 REMARK 465 PRO N 154 REMARK 465 VAL N 155 REMARK 465 THR N 156 REMARK 465 VAL N 157 REMARK 465 SER N 158 REMARK 465 TRP N 159 REMARK 465 ASN N 160 REMARK 465 SER N 161 REMARK 465 GLY N 162 REMARK 465 ALA N 163 REMARK 465 LEU N 164 REMARK 465 THR N 165 REMARK 465 SER N 166 REMARK 465 GLY N 167 REMARK 465 VAL N 168 REMARK 465 HIS N 169 REMARK 465 THR N 170 REMARK 465 PHE N 171 REMARK 465 PRO N 172 REMARK 465 ALA N 173 REMARK 465 VAL N 174 REMARK 465 LEU N 175 REMARK 465 GLN N 176 REMARK 465 SER N 177 REMARK 465 SER N 178 REMARK 465 GLY N 179 REMARK 465 LEU N 180 REMARK 465 TYR N 181 REMARK 465 SER N 182 REMARK 465 LEU N 183 REMARK 465 SER N 184 REMARK 465 SER N 185 REMARK 465 VAL N 186 REMARK 465 VAL N 187 REMARK 465 THR N 188 REMARK 465 VAL N 189 REMARK 465 PRO N 190 REMARK 465 SER N 191 REMARK 465 SER N 192 REMARK 465 SER N 193 REMARK 465 LEU N 194 REMARK 465 GLY N 195 REMARK 465 THR N 196 REMARK 465 GLN N 197 REMARK 465 THR N 198 REMARK 465 TYR N 199 REMARK 465 ILE N 200 REMARK 465 CYS N 201 REMARK 465 ASN N 202 REMARK 465 VAL N 203 REMARK 465 ASN N 204 REMARK 465 HIS N 205 REMARK 465 LYS N 206 REMARK 465 PRO N 207 REMARK 465 SER N 208 REMARK 465 ASN N 209 REMARK 465 THR N 210 REMARK 465 LYS N 211 REMARK 465 VAL N 212 REMARK 465 ASP N 213 REMARK 465 LYS N 214 REMARK 465 LYS N 215 REMARK 465 VAL N 216 REMARK 465 GLU N 217 REMARK 465 PRO N 218 REMARK 465 LYS N 219 REMARK 465 SER N 220 REMARK 465 CYS N 221 REMARK 465 ASP N 222 REMARK 465 LYS N 223 REMARK 465 THR N 224 REMARK 465 HIS N 225 REMARK 465 THR N 226 REMARK 465 CYS N 227 REMARK 465 PRO N 228 REMARK 465 PRO N 229 REMARK 465 CYS N 230 REMARK 465 PRO N 231 REMARK 465 ALA N 232 REMARK 465 PRO N 233 REMARK 465 GLU N 234 REMARK 465 LEU N 235 REMARK 465 LEU N 236 REMARK 465 GLY N 237 REMARK 465 GLY N 238 REMARK 465 PRO N 239 REMARK 465 SER N 240 REMARK 465 VAL N 241 REMARK 465 PHE N 242 REMARK 465 LEU N 243 REMARK 465 PHE N 244 REMARK 465 PRO N 245 REMARK 465 PRO N 246 REMARK 465 LYS N 247 REMARK 465 PRO N 248 REMARK 465 LYS N 249 REMARK 465 ASP N 250 REMARK 465 THR N 251 REMARK 465 LEU N 252 REMARK 465 MET N 253 REMARK 465 ILE N 254 REMARK 465 SER N 255 REMARK 465 ARG N 256 REMARK 465 THR N 257 REMARK 465 PRO N 258 REMARK 465 GLU N 259 REMARK 465 VAL N 260 REMARK 465 THR N 261 REMARK 465 CYS N 262 REMARK 465 VAL N 263 REMARK 465 VAL N 264 REMARK 465 VAL N 265 REMARK 465 ASP N 266 REMARK 465 VAL N 267 REMARK 465 SER N 268 REMARK 465 HIS N 269 REMARK 465 GLU N 270 REMARK 465 ASP N 271 REMARK 465 PRO N 272 REMARK 465 GLU N 273 REMARK 465 VAL N 274 REMARK 465 LYS N 275 REMARK 465 PHE N 276 REMARK 465 ASN N 277 REMARK 465 TRP N 278 REMARK 465 TYR N 279 REMARK 465 VAL N 280 REMARK 465 ASP N 281 REMARK 465 GLY N 282 REMARK 465 VAL N 283 REMARK 465 GLU N 284 REMARK 465 VAL N 285 REMARK 465 HIS N 286 REMARK 465 ASN N 287 REMARK 465 ALA N 288 REMARK 465 LYS N 289 REMARK 465 THR N 290 REMARK 465 LYS N 291 REMARK 465 PRO N 292 REMARK 465 ARG N 293 REMARK 465 GLU N 294 REMARK 465 GLU N 295 REMARK 465 GLN N 296 REMARK 465 TYR N 297 REMARK 465 ASN N 298 REMARK 465 SER N 299 REMARK 465 THR N 300 REMARK 465 TYR N 301 REMARK 465 ARG N 302 REMARK 465 VAL N 303 REMARK 465 VAL N 304 REMARK 465 SER N 305 REMARK 465 VAL N 306 REMARK 465 LEU N 307 REMARK 465 THR N 308 REMARK 465 VAL N 309 REMARK 465 LEU N 310 REMARK 465 HIS N 311 REMARK 465 GLN N 312 REMARK 465 ASP N 313 REMARK 465 TRP N 314 REMARK 465 LEU N 315 REMARK 465 ASN N 316 REMARK 465 GLY N 317 REMARK 465 LYS N 318 REMARK 465 GLU N 319 REMARK 465 TYR N 320 REMARK 465 LYS N 321 REMARK 465 CYS N 322 REMARK 465 LYS N 323 REMARK 465 VAL N 324 REMARK 465 SER N 325 REMARK 465 ASN N 326 REMARK 465 LYS N 327 REMARK 465 ALA N 328 REMARK 465 LEU N 329 REMARK 465 PRO N 330 REMARK 465 ALA N 331 REMARK 465 PRO N 332 REMARK 465 ILE N 333 REMARK 465 GLU N 334 REMARK 465 LYS N 335 REMARK 465 THR N 336 REMARK 465 ILE N 337 REMARK 465 SER N 338 REMARK 465 LYS N 339 REMARK 465 ALA N 340 REMARK 465 LYS N 341 REMARK 465 GLY N 342 REMARK 465 GLN N 343 REMARK 465 PRO N 344 REMARK 465 ARG N 345 REMARK 465 GLU N 346 REMARK 465 PRO N 347 REMARK 465 GLN N 348 REMARK 465 VAL N 349 REMARK 465 TYR N 350 REMARK 465 THR N 351 REMARK 465 LEU N 352 REMARK 465 PRO N 353 REMARK 465 PRO N 354 REMARK 465 SER N 355 REMARK 465 ARG N 356 REMARK 465 ASP N 357 REMARK 465 GLU N 358 REMARK 465 LEU N 359 REMARK 465 THR N 360 REMARK 465 LYS N 361 REMARK 465 ASN N 362 REMARK 465 GLN N 363 REMARK 465 VAL N 364 REMARK 465 SER N 365 REMARK 465 LEU N 366 REMARK 465 THR N 367 REMARK 465 CYS N 368 REMARK 465 LEU N 369 REMARK 465 VAL N 370 REMARK 465 LYS N 371 REMARK 465 GLY N 372 REMARK 465 PHE N 373 REMARK 465 TYR N 374 REMARK 465 PRO N 375 REMARK 465 SER N 376 REMARK 465 ASP N 377 REMARK 465 ILE N 378 REMARK 465 ALA N 379 REMARK 465 VAL N 380 REMARK 465 GLU N 381 REMARK 465 TRP N 382 REMARK 465 GLU N 383 REMARK 465 SER N 384 REMARK 465 ASN N 385 REMARK 465 GLY N 386 REMARK 465 GLN N 387 REMARK 465 PRO N 388 REMARK 465 GLU N 389 REMARK 465 ASN N 390 REMARK 465 ASN N 391 REMARK 465 TYR N 392 REMARK 465 LYS N 393 REMARK 465 THR N 394 REMARK 465 THR N 395 REMARK 465 PRO N 396 REMARK 465 PRO N 397 REMARK 465 VAL N 398 REMARK 465 SER Y 137 REMARK 465 SER Y 138 REMARK 465 LYS Y 139 REMARK 465 SER Y 140 REMARK 465 THR Y 141 REMARK 465 SER Y 142 REMARK 465 GLY Y 143 REMARK 465 GLY Y 144 REMARK 465 THR Y 145 REMARK 465 ALA Y 146 REMARK 465 LEU Y 169 REMARK 465 THR Y 170 REMARK 465 SER Y 171 REMARK 465 GLY Y 172 REMARK 465 THR Y 193 REMARK 465 VAL Y 194 REMARK 465 PRO Y 195 REMARK 465 SER Y 196 REMARK 465 SER Y 197 REMARK 465 SER Y 198 REMARK 465 LEU Y 199 REMARK 465 GLY Y 200 REMARK 465 THR Y 201 REMARK 465 GLN Y 202 REMARK 465 THR Y 203 REMARK 465 TYR Y 204 REMARK 465 ILE Y 205 REMARK 465 GLU Y 222 REMARK 465 PRO Y 223 REMARK 465 LYS Y 224 REMARK 465 SER Y 225 REMARK 465 CYS Y 226 REMARK 465 ASP Y 227 REMARK 465 LYS Y 228 REMARK 465 THR Y 229 REMARK 465 HIS Y 230 REMARK 465 THR Y 231 REMARK 465 CYS Y 232 REMARK 465 PRO Y 233 REMARK 465 PRO Y 234 REMARK 465 CYS Y 235 REMARK 465 PRO Y 236 REMARK 465 ALA Y 237 REMARK 465 PRO Y 238 REMARK 465 GLU Y 239 REMARK 465 LEU Y 240 REMARK 465 LEU Y 241 REMARK 465 GLY Y 242 REMARK 465 GLY Y 243 REMARK 465 PRO Y 244 REMARK 465 SER Y 245 REMARK 465 VAL Y 246 REMARK 465 PHE Y 247 REMARK 465 LEU Y 248 REMARK 465 PHE Y 249 REMARK 465 PRO Y 250 REMARK 465 PRO Y 251 REMARK 465 LYS Y 252 REMARK 465 PRO Y 253 REMARK 465 LYS Y 254 REMARK 465 ASP Y 255 REMARK 465 THR Y 256 REMARK 465 LEU Y 257 REMARK 465 MET Y 258 REMARK 465 ILE Y 259 REMARK 465 SER Y 260 REMARK 465 ARG Y 261 REMARK 465 THR Y 262 REMARK 465 PRO Y 263 REMARK 465 GLU Y 264 REMARK 465 VAL Y 265 REMARK 465 THR Y 266 REMARK 465 CYS Y 267 REMARK 465 VAL Y 268 REMARK 465 VAL Y 269 REMARK 465 VAL Y 270 REMARK 465 ASP Y 271 REMARK 465 VAL Y 272 REMARK 465 SER Y 273 REMARK 465 HIS Y 274 REMARK 465 GLU Y 275 REMARK 465 ASP Y 276 REMARK 465 PRO Y 277 REMARK 465 GLU Y 278 REMARK 465 VAL Y 279 REMARK 465 LYS Y 280 REMARK 465 PHE Y 281 REMARK 465 ASN Y 282 REMARK 465 TRP Y 283 REMARK 465 TYR Y 284 REMARK 465 VAL Y 285 REMARK 465 ASP Y 286 REMARK 465 GLY Y 287 REMARK 465 VAL Y 288 REMARK 465 GLU Y 289 REMARK 465 VAL Y 290 REMARK 465 HIS Y 291 REMARK 465 ASN Y 292 REMARK 465 ALA Y 293 REMARK 465 LYS Y 294 REMARK 465 THR Y 295 REMARK 465 LYS Y 296 REMARK 465 PRO Y 297 REMARK 465 ARG Y 298 REMARK 465 GLU Y 299 REMARK 465 GLU Y 300 REMARK 465 GLN Y 301 REMARK 465 TYR Y 302 REMARK 465 ASN Y 303 REMARK 465 SER Y 304 REMARK 465 THR Y 305 REMARK 465 TYR Y 306 REMARK 465 ARG Y 307 REMARK 465 VAL Y 308 REMARK 465 VAL Y 309 REMARK 465 SER Y 310 REMARK 465 VAL Y 311 REMARK 465 LEU Y 312 REMARK 465 THR Y 313 REMARK 465 VAL Y 314 REMARK 465 LEU Y 315 REMARK 465 HIS Y 316 REMARK 465 GLN Y 317 REMARK 465 ASP Y 318 REMARK 465 TRP Y 319 REMARK 465 LEU Y 320 REMARK 465 ASN Y 321 REMARK 465 GLY Y 322 REMARK 465 LYS Y 323 REMARK 465 GLU Y 324 REMARK 465 TYR Y 325 REMARK 465 LYS Y 326 REMARK 465 CYS Y 327 REMARK 465 LYS Y 328 REMARK 465 VAL Y 329 REMARK 465 SER Y 330 REMARK 465 ASN Y 331 REMARK 465 LYS Y 332 REMARK 465 ALA Y 333 REMARK 465 LEU Y 334 REMARK 465 PRO Y 335 REMARK 465 ALA Y 336 REMARK 465 PRO Y 337 REMARK 465 ILE Y 338 REMARK 465 GLU Y 339 REMARK 465 LYS Y 340 REMARK 465 THR Y 341 REMARK 465 ILE Y 342 REMARK 465 SER Y 343 REMARK 465 LYS Y 344 REMARK 465 ALA Y 345 REMARK 465 LYS Y 346 REMARK 465 GLY Y 347 REMARK 465 GLN Y 348 REMARK 465 PRO Y 349 REMARK 465 ARG Y 350 REMARK 465 GLU Y 351 REMARK 465 PRO Y 352 REMARK 465 GLN Y 353 REMARK 465 VAL Y 354 REMARK 465 TYR Y 355 REMARK 465 THR Y 356 REMARK 465 LEU Y 357 REMARK 465 PRO Y 358 REMARK 465 PRO Y 359 REMARK 465 SER Y 360 REMARK 465 ARG Y 361 REMARK 465 ASP Y 362 REMARK 465 GLU Y 363 REMARK 465 LEU Y 364 REMARK 465 THR Y 365 REMARK 465 LYS Y 366 REMARK 465 ASN Y 367 REMARK 465 GLN Y 368 REMARK 465 VAL Y 369 REMARK 465 SER Y 370 REMARK 465 LEU Y 371 REMARK 465 THR Y 372 REMARK 465 CYS Y 373 REMARK 465 LEU Y 374 REMARK 465 VAL Y 375 REMARK 465 LYS Y 376 REMARK 465 GLY Y 377 REMARK 465 PHE Y 378 REMARK 465 TYR Y 379 REMARK 465 PRO Y 380 REMARK 465 SER Y 381 REMARK 465 ASP Y 382 REMARK 465 ILE Y 383 REMARK 465 ALA Y 384 REMARK 465 VAL Y 385 REMARK 465 GLU Y 386 REMARK 465 TRP Y 387 REMARK 465 GLU Y 388 REMARK 465 SER Y 389 REMARK 465 ASN Y 390 REMARK 465 GLY Y 391 REMARK 465 GLN Y 392 REMARK 465 PRO Y 393 REMARK 465 GLU Y 394 REMARK 465 ASN Y 395 REMARK 465 ASN Y 396 REMARK 465 TYR Y 397 REMARK 465 LYS Y 398 REMARK 465 THR Y 399 REMARK 465 THR Y 400 REMARK 465 PRO Y 401 REMARK 465 PRO Y 402 REMARK 465 VAL Y 403 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 VAL A 24 CG1 CG2 REMARK 470 GLU A 25 CG CD OE1 OE2 REMARK 470 GLU A 28 CG CD OE1 OE2 REMARK 470 ASP A 34 CG OD1 OD2 REMARK 470 ASN A 91 CG OD1 ND2 REMARK 470 ASN A 98 CG OD1 ND2 REMARK 470 ARG A 206 NE CZ NH1 NH2 REMARK 470 GLU A 208 CG CD OE1 OE2 REMARK 470 LYS A 288 CG CD CE NZ REMARK 470 ASN A 289 CG OD1 ND2 REMARK 470 VAL B 24 CG1 CG2 REMARK 470 VAL B 33 CG1 CG2 REMARK 470 ASN B 91 CG OD1 ND2 REMARK 470 LYS B 288 CG CD CE NZ REMARK 470 GLU C 25 CG CD OE1 OE2 REMARK 470 VAL C 33 CG1 CG2 REMARK 470 ARG C 286 CG CD NE CZ NH1 NH2 REMARK 470 LYS C 288 CG CD CE NZ REMARK 470 ASN C 289 CG OD1 ND2 REMARK 470 VAL D 24 CG1 CG2 REMARK 470 GLU D 25 CG CD OE1 OE2 REMARK 470 ASN D 91 CG OD1 ND2 REMARK 470 ASN D 98 CG OD1 ND2 REMARK 470 ARG D 286 CG CD NE CZ NH1 NH2 REMARK 470 LYS D 288 CG CD CE NZ REMARK 470 ASN D 289 CG OD1 ND2 REMARK 470 MET E 21 CG SD CE REMARK 470 VAL E 24 CG1 CG2 REMARK 470 GLU E 28 CG CD OE1 OE2 REMARK 470 ILE E 99 CG1 CG2 CD1 REMARK 470 ARG E 286 CG CD NE CZ NH1 NH2 REMARK 470 LYS E 288 CG CD CE NZ REMARK 470 ASN E 289 CG OD1 ND2 REMARK 470 ARG F 17 CG CD NE CZ NH1 NH2 REMARK 470 THR F 43 CG2 REMARK 470 LYS F 114 CG CD CE NZ REMARK 470 LYS F 133 CG CD CE NZ REMARK 470 PHE F 143 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR F 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS F 167 CG CD CE NZ REMARK 470 LYS F 170 CG CD CE NZ REMARK 470 GLN F 171 CG CD OE1 NE2 REMARK 470 LYS F 175 CG CD CE NZ REMARK 470 TYR F 195 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLN F 198 CG CD OE1 NE2 REMARK 470 GLU F 207 CG CD OE1 OE2 REMARK 470 LYS F 208 CG CD CE NZ REMARK 470 THR G 43 CG2 REMARK 470 ASP G 61 CG OD1 OD2 REMARK 470 LYS G 114 CG CD CE NZ REMARK 470 LEU G 136 CG CD1 CD2 REMARK 470 ILE G 140 CG1 CG2 CD1 REMARK 470 ASP G 142 CG OD1 OD2 REMARK 470 PHE G 143 CG CD1 CD2 CE1 CE2 CZ REMARK 470 TYR G 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS G 167 CG CD CE NZ REMARK 470 LYS G 170 CG CD CE NZ REMARK 470 GLN G 171 CG CD OE1 NE2 REMARK 470 ASN G 174 CG OD1 ND2 REMARK 470 LYS G 175 CG CD CE NZ REMARK 470 TYR G 195 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLN G 198 CG CD OE1 NE2 REMARK 470 GLU G 202 CG CD OE1 OE2 REMARK 470 GLU G 207 CG CD OE1 OE2 REMARK 470 LYS G 208 CG CD CE NZ REMARK 470 GLU H 1 CG CD OE1 OE2 REMARK 470 LYS H 43 CG CD CE NZ REMARK 470 THR H 56 CG2 REMARK 470 ARG H 76 NH1 NH2 REMARK 470 TYR H 95 OH REMARK 470 LYS H 122 CG CD CE NZ REMARK 470 LYS H 153 CG CD CE NZ REMARK 470 GLN H 181 CG CD OE1 NE2 REMARK 470 ASN I 28 CG OD1 ND2 REMARK 470 THR I 43 CG2 REMARK 470 ASN I 132 CG OD1 ND2 REMARK 470 LYS I 133 CG CD CE NZ REMARK 470 GLU I 164 CG CD OE1 OE2 REMARK 470 THR I 165 OG1 CG2 REMARK 470 THR I 166 OG1 CG2 REMARK 470 LYS I 167 CG CD CE NZ REMARK 470 TYR I 181 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LEU I 182 CG CD1 CD2 REMARK 470 GLU J 1 CG CD OE1 OE2 REMARK 470 LYS J 13 CG CD CE NZ REMARK 470 LYS J 43 CG CD CE NZ REMARK 470 THR J 56 CG2 REMARK 470 LYS J 65 CG CD CE NZ REMARK 470 ARG J 76 NH1 NH2 REMARK 470 TYR J 95 OH REMARK 470 LYS J 122 CG CD CE NZ REMARK 470 VAL J 126 CG1 CG2 REMARK 470 LEU J 148 CG CD1 CD2 REMARK 470 LYS J 153 CG CD CE NZ REMARK 470 ASP J 154 CG OD1 OD2 REMARK 470 GLN J 181 CG CD OE1 NE2 REMARK 470 LYS J 211 CG CD CE NZ REMARK 470 LYS J 216 CG CD CE NZ REMARK 470 LYS J 219 CG CD CE NZ REMARK 470 THR K 43 CG2 REMARK 470 SER K 57 OG REMARK 470 GLU K 82 CG CD OE1 OE2 REMARK 470 TYR K 144 CG CD1 CD2 CE1 CE2 CZ OH REMARK 470 LYS K 167 CG CD CE NZ REMARK 470 LYS K 170 CG CD CE NZ REMARK 470 GLU L 1 CG CD OE1 OE2 REMARK 470 LYS L 13 CG CD CE NZ REMARK 470 LYS L 43 CG CD CE NZ REMARK 470 THR L 56 CG2 REMARK 470 LYS L 65 CG CD CE NZ REMARK 470 ARG L 76 NH1 NH2 REMARK 470 TYR L 95 OH REMARK 470 LYS L 122 CG CD CE NZ REMARK 470 LYS L 153 CG CD CE NZ REMARK 470 PHE L 176 CG CD1 CD2 CE1 CE2 CZ REMARK 470 LEU L 180 CG CD1 CD2 REMARK 470 LYS L 211 CG CD CE NZ REMARK 470 ARG M 17 CG CD NE CZ NH1 NH2 REMARK 470 THR M 43 CG2 REMARK 470 GLU N 1 CG CD OE1 OE2 REMARK 470 LYS N 43 CG CD CE NZ REMARK 470 THR N 56 CG2 REMARK 470 ARG N 76 NH1 NH2 REMARK 470 TYR N 95 OH REMARK 470 GLU Y 1 CG CD OE1 OE2 REMARK 470 LYS Y 43 CG CD CE NZ REMARK 470 THR Y 56 CG2 REMARK 470 LYS Y 65 CG CD CE NZ REMARK 470 ARG Y 76 NH1 NH2 REMARK 470 TYR Y 95 OH REMARK 470 LYS Y 122 CG CD CE NZ REMARK 470 SER Y 166 OG REMARK 470 GLN Y 181 CG CD OE1 NE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SERAA 71 78.93 -155.86 REMARK 500 ASPAA 166 119.51 -34.60 REMARK 500 METAA 181 133.45 -175.04 REMARK 500 ARGAA 206 -150.13 -129.70 REMARK 500 THRAA 229 145.16 -170.48 REMARK 500 SERBB 71 78.13 -154.40 REMARK 500 ASPBB 166 118.79 -35.15 REMARK 500 METBB 181 133.98 -174.09 REMARK 500 ARGBB 206 -150.11 -130.53 REMARK 500 THRBB 229 143.21 -170.54 REMARK 500 LEUCC 27 -158.45 -95.97 REMARK 500 ASPCC 49 74.60 42.77 REMARK 500 GLUCC 52 -15.07 -48.94 REMARK 500 SERCC 71 77.75 -154.69 REMARK 500 ALACC 126 123.15 -39.97 REMARK 500 ASPCC 166 120.68 -38.86 REMARK 500 METCC 181 133.74 -173.61 REMARK 500 ARGCC 206 -149.91 -130.92 REMARK 500 THRCC 229 142.58 -172.23 REMARK 500 LEUDD 27 -157.26 -96.13 REMARK 500 SERDD 71 79.61 -156.22 REMARK 500 ASPDD 166 118.17 -33.89 REMARK 500 METDD 181 133.73 -174.92 REMARK 500 ARGDD 206 -150.01 -132.22 REMARK 500 THRDD 229 142.38 -173.49 REMARK 500 LEUEE 27 -139.60 -96.93 REMARK 500 SEREE 71 78.22 -155.39 REMARK 500 ASPEE 166 120.39 -36.33 REMARK 500 METEE 181 133.41 -174.69 REMARK 500 ARGEE 206 75.90 -164.24 REMARK 500 THREE 229 144.26 -172.16 REMARK 500 ASNFF 28 -92.73 -113.89 REMARK 500 PROFF 41 131.35 -36.81 REMARK 500 ASNFF 52 -42.09 80.18 REMARK 500 ASPFF 61 -37.13 -37.58 REMARK 500 PROFF 117 88.30 -69.59 REMARK 500 PROFF 124 -179.29 -55.61 REMARK 500 SERFF 125 -43.63 -141.11 REMARK 500 ASPFF 142 74.41 55.00 REMARK 500 ASNFF 174 62.39 30.75 REMARK 500 HISFF 201 99.71 -164.25 REMARK 500 VALFF 206 45.98 -144.19 REMARK 500 ASNGG 28 -96.92 -107.81 REMARK 500 ASNGG 52 -42.49 79.55 REMARK 500 ASPGG 61 -37.21 -38.47 REMARK 500 ASPGG 142 93.30 -5.06 REMARK 500 ASNGG 174 63.31 31.55 REMARK 500 HISGG 201 103.65 -164.83 REMARK 500 VALGG 206 43.86 -141.17 REMARK 500 ALAGG 211 87.03 -154.39 REMARK 500 REMARK 500 THIS ENTRY HAS 94 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL DBREF 7PA8AA 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PA8BB 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PA8CC 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PA8DD 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PA8EE 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PA8FF 1 212 PDB 7PA8 7PA8 1 212 DBREF 7PA8GG 1 212 PDB 7PA8 7PA8 1 212 DBREF 7PA8HH 1 403 PDB 7PA8 7PA8 1 403 DBREF 7PA8II 1 212 PDB 7PA8 7PA8 1 212 DBREF 7PA8JJ 1 403 PDB 7PA8 7PA8 1 403 DBREF 7PA8KK 1 212 PDB 7PA8 7PA8 1 212 DBREF 7PA8LL 1 403 PDB 7PA8 7PA8 1 403 DBREF 7PA8MM 1 212 PDB 7PA8 7PA8 1 212 DBREF 7PA8NN 1 398 PDB 7PA8 7PA8 1 398 DBREF 7PA8YY 1 403 PDB 7PA8 7PA8 1 403 SEQADV 7PA8 GLYAA 18 UNP P03089 EXPRESSION TAG SEQADV 7PA8 SERAA 19 UNP P03089 EXPRESSION TAG SEQADV 7PA8 HISAA 20 UNP P03089 EXPRESSION TAG SEQADV 7PA8 METAA 21 UNP P03089 EXPRESSION TAG SEQADV 7PA8 GLYBB 18 UNP P03089 EXPRESSION TAG SEQADV 7PA8 SERBB 19 UNP P03089 EXPRESSION TAG SEQADV 7PA8 HISBB 20 UNP P03089 EXPRESSION TAG SEQADV 7PA8 METBB 21 UNP P03089 EXPRESSION TAG SEQADV 7PA8 GLYCC 18 UNP P03089 EXPRESSION TAG SEQADV 7PA8 SERCC 19 UNP P03089 EXPRESSION TAG SEQADV 7PA8 HISCC 20 UNP P03089 EXPRESSION TAG SEQADV 7PA8 METCC 21 UNP P03089 EXPRESSION TAG SEQADV 7PA8 GLYDD 18 UNP P03089 EXPRESSION TAG SEQADV 7PA8 SERDD 19 UNP P03089 EXPRESSION TAG SEQADV 7PA8 HISDD 20 UNP P03089 EXPRESSION TAG SEQADV 7PA8 METDD 21 UNP P03089 EXPRESSION TAG SEQADV 7PA8 GLYEE 18 UNP P03089 EXPRESSION TAG SEQADV 7PA8 SEREE 19 UNP P03089 EXPRESSION TAG SEQADV 7PA8 HISEE 20 UNP P03089 EXPRESSION TAG SEQADV 7PA8 METEE 21 UNP P03089 EXPRESSION TAG SEQRES 1AA 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2AA 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3AA 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4AA 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5AA 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6AA 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7AA 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8AA 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9AA 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10AA 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11AA 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12AA 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13AA 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14AA 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15AA 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16AA 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17AA 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18AA 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19AA 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20AA 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21AA 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1BB 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2BB 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3BB 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4BB 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5BB 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6BB 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7BB 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8BB 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9BB 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10BB 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11BB 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12BB 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13BB 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14BB 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15BB 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16BB 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17BB 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18BB 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19BB 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20BB 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21BB 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1CC 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2CC 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3CC 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4CC 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5CC 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6CC 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7CC 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8CC 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9CC 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10CC 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11CC 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12CC 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13CC 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14CC 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15CC 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16CC 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17CC 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18CC 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19CC 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20CC 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21CC 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1DD 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2DD 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3DD 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4DD 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5DD 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6DD 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7DD 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8DD 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9DD 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10DD 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11DD 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12DD 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13DD 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14DD 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15DD 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16DD 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17DD 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18DD 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19DD 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20DD 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21DD 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1EE 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2EE 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3EE 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4EE 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5EE 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6EE 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7EE 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8EE 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9EE 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10EE 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11EE 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12EE 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13EE 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14EE 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15EE 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16EE 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17EE 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18EE 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19EE 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20EE 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21EE 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1FF 212 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2FF 212 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3FF 212 SER ASN ILE GLY SER ASN PRO VAL ASN TRP PHE GLN GLN SEQRES 4FF 212 PHE PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ALA ASN SEQRES 5FF 212 THR GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6FF 212 SER LYS SER GLY THR SER VAL SER LEU ALA ILE SER GLY SEQRES 7FF 212 LEU GLN SER GLU ASP GLU GLY ASP TYR HIS CYS ALA ALA SEQRES 8FF 212 TRP ASP ASP SER LEU LYS GLY TRP VAL PHE GLY GLY GLY SEQRES 9FF 212 THR LYS LEU THR VAL LEU GLY ALA PRO LYS ALA ASN PRO SEQRES 10FF 212 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11FF 212 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12FF 212 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP GLY SEQRES 13FF 212 SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SER SEQRES 14FF 212 LYS GLN SER ASN ASN LYS THR ALA ALA SER SER TYR LEU SEQRES 15FF 212 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16FF 212 SER CYS GLN VAL THR HIS GLU GLY THR THR VAL GLU LYS SEQRES 17FF 212 THR VAL ALA PRO SEQRES 1GG 212 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2GG 212 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3GG 212 SER ASN ILE GLY SER ASN PRO VAL ASN TRP PHE GLN GLN SEQRES 4GG 212 PHE PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ALA ASN SEQRES 5GG 212 THR GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6GG 212 SER LYS SER GLY THR SER VAL SER LEU ALA ILE SER GLY SEQRES 7GG 212 LEU GLN SER GLU ASP GLU GLY ASP TYR HIS CYS ALA ALA SEQRES 8GG 212 TRP ASP ASP SER LEU LYS GLY TRP VAL PHE GLY GLY GLY SEQRES 9GG 212 THR LYS LEU THR VAL LEU GLY ALA PRO LYS ALA ASN PRO SEQRES 10GG 212 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11GG 212 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12GG 212 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP GLY SEQRES 13GG 212 SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SER SEQRES 14GG 212 LYS GLN SER ASN ASN LYS THR ALA ALA SER SER TYR LEU SEQRES 15GG 212 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16GG 212 SER CYS GLN VAL THR HIS GLU GLY THR THR VAL GLU LYS SEQRES 17GG 212 THR VAL ALA PRO SEQRES 1HH 398 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2HH 398 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3HH 398 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4HH 398 ALA PRO GLY LYS GLY LEU GLN TRP VAL SER SER ILE SER SEQRES 5HH 398 SER SER SER THR TYR MET TYR TYR GLY ASP SER VAL LYS SEQRES 6HH 398 GLY ARG PHE THR ILE SER ARG ASP ASN ALA ARG ASN SER SEQRES 7HH 398 LEU TYR LEU GLN MET ASN SER LEU ARG VAL GLU ASP THR SEQRES 8HH 398 ALA VAL TYR TYR CYS ALA ARG TYR ALA HIS ASP TRP ASN SEQRES 9HH 398 VAL ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10HH 398 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11HH 398 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12HH 398 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13HH 398 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14HH 398 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15HH 398 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16HH 398 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17HH 398 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 18HH 398 ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO GLU SEQRES 19HH 398 LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO LYS SEQRES 20HH 398 PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU VAL SEQRES 21HH 398 THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO GLU SEQRES 22HH 398 VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL HIS SEQRES 23HH 398 ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SER SEQRES 24HH 398 THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS GLN SEQRES 25HH 398 ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SER SEQRES 26HH 398 ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SER SEQRES 27HH 398 LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR THR SEQRES 28HH 398 LEU PRO PRO SER ARG ASP GLU LEU THR LYS ASN GLN VAL SEQRES 29HH 398 SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER ASP SEQRES 30HH 398 ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU ASN SEQRES 31HH 398 ASN TYR LYS THR THR PRO PRO VAL SEQRES 1II 212 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2II 212 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3II 212 SER ASN ILE GLY SER ASN PRO VAL ASN TRP PHE GLN GLN SEQRES 4II 212 PHE PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ALA ASN SEQRES 5II 212 THR GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6II 212 SER LYS SER GLY THR SER VAL SER LEU ALA ILE SER GLY SEQRES 7II 212 LEU GLN SER GLU ASP GLU GLY ASP TYR HIS CYS ALA ALA SEQRES 8II 212 TRP ASP ASP SER LEU LYS GLY TRP VAL PHE GLY GLY GLY SEQRES 9II 212 THR LYS LEU THR VAL LEU GLY ALA PRO LYS ALA ASN PRO SEQRES 10II 212 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11II 212 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12II 212 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP GLY SEQRES 13II 212 SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SER SEQRES 14II 212 LYS GLN SER ASN ASN LYS THR ALA ALA SER SER TYR LEU SEQRES 15II 212 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16II 212 SER CYS GLN VAL THR HIS GLU GLY THR THR VAL GLU LYS SEQRES 17II 212 THR VAL ALA PRO SEQRES 1JJ 398 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2JJ 398 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3JJ 398 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4JJ 398 ALA PRO GLY LYS GLY LEU GLN TRP VAL SER SER ILE SER SEQRES 5JJ 398 SER SER SER THR TYR MET TYR TYR GLY ASP SER VAL LYS SEQRES 6JJ 398 GLY ARG PHE THR ILE SER ARG ASP ASN ALA ARG ASN SER SEQRES 7JJ 398 LEU TYR LEU GLN MET ASN SER LEU ARG VAL GLU ASP THR SEQRES 8JJ 398 ALA VAL TYR TYR CYS ALA ARG TYR ALA HIS ASP TRP ASN SEQRES 9JJ 398 VAL ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10JJ 398 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11JJ 398 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12JJ 398 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13JJ 398 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14JJ 398 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15JJ 398 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16JJ 398 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17JJ 398 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 18JJ 398 ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO GLU SEQRES 19JJ 398 LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO LYS SEQRES 20JJ 398 PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU VAL SEQRES 21JJ 398 THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO GLU SEQRES 22JJ 398 VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL HIS SEQRES 23JJ 398 ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SER SEQRES 24JJ 398 THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS GLN SEQRES 25JJ 398 ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SER SEQRES 26JJ 398 ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SER SEQRES 27JJ 398 LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR THR SEQRES 28JJ 398 LEU PRO PRO SER ARG ASP GLU LEU THR LYS ASN GLN VAL SEQRES 29JJ 398 SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER ASP SEQRES 30JJ 398 ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU ASN SEQRES 31JJ 398 ASN TYR LYS THR THR PRO PRO VAL SEQRES 1KK 212 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2KK 212 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3KK 212 SER ASN ILE GLY SER ASN PRO VAL ASN TRP PHE GLN GLN SEQRES 4KK 212 PHE PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ALA ASN SEQRES 5KK 212 THR GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6KK 212 SER LYS SER GLY THR SER VAL SER LEU ALA ILE SER GLY SEQRES 7KK 212 LEU GLN SER GLU ASP GLU GLY ASP TYR HIS CYS ALA ALA SEQRES 8KK 212 TRP ASP ASP SER LEU LYS GLY TRP VAL PHE GLY GLY GLY SEQRES 9KK 212 THR LYS LEU THR VAL LEU GLY ALA PRO LYS ALA ASN PRO SEQRES 10KK 212 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11KK 212 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12KK 212 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP GLY SEQRES 13KK 212 SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SER SEQRES 14KK 212 LYS GLN SER ASN ASN LYS THR ALA ALA SER SER TYR LEU SEQRES 15KK 212 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16KK 212 SER CYS GLN VAL THR HIS GLU GLY THR THR VAL GLU LYS SEQRES 17KK 212 THR VAL ALA PRO SEQRES 1LL 398 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2LL 398 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3LL 398 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4LL 398 ALA PRO GLY LYS GLY LEU GLN TRP VAL SER SER ILE SER SEQRES 5LL 398 SER SER SER THR TYR MET TYR TYR GLY ASP SER VAL LYS SEQRES 6LL 398 GLY ARG PHE THR ILE SER ARG ASP ASN ALA ARG ASN SER SEQRES 7LL 398 LEU TYR LEU GLN MET ASN SER LEU ARG VAL GLU ASP THR SEQRES 8LL 398 ALA VAL TYR TYR CYS ALA ARG TYR ALA HIS ASP TRP ASN SEQRES 9LL 398 VAL ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10LL 398 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11LL 398 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12LL 398 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13LL 398 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14LL 398 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15LL 398 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16LL 398 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17LL 398 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 18LL 398 ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO GLU SEQRES 19LL 398 LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO LYS SEQRES 20LL 398 PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU VAL SEQRES 21LL 398 THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO GLU SEQRES 22LL 398 VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL HIS SEQRES 23LL 398 ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SER SEQRES 24LL 398 THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS GLN SEQRES 25LL 398 ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SER SEQRES 26LL 398 ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SER SEQRES 27LL 398 LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR THR SEQRES 28LL 398 LEU PRO PRO SER ARG ASP GLU LEU THR LYS ASN GLN VAL SEQRES 29LL 398 SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER ASP SEQRES 30LL 398 ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU ASN SEQRES 31LL 398 ASN TYR LYS THR THR PRO PRO VAL SEQRES 1MM 212 GLN SER VAL LEU THR GLN PRO PRO SER ALA SER GLY THR SEQRES 2MM 212 PRO GLY GLN ARG VAL THR ILE SER CYS SER GLY GLY SER SEQRES 3MM 212 SER ASN ILE GLY SER ASN PRO VAL ASN TRP PHE GLN GLN SEQRES 4MM 212 PHE PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ALA ASN SEQRES 5MM 212 THR GLN ARG PRO SER GLY VAL PRO ASP ARG PHE SER GLY SEQRES 6MM 212 SER LYS SER GLY THR SER VAL SER LEU ALA ILE SER GLY SEQRES 7MM 212 LEU GLN SER GLU ASP GLU GLY ASP TYR HIS CYS ALA ALA SEQRES 8MM 212 TRP ASP ASP SER LEU LYS GLY TRP VAL PHE GLY GLY GLY SEQRES 9MM 212 THR LYS LEU THR VAL LEU GLY ALA PRO LYS ALA ASN PRO SEQRES 10MM 212 THR VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN SEQRES 11MM 212 ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE SEQRES 12MM 212 TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP GLY SEQRES 13MM 212 SER PRO VAL LYS ALA GLY VAL GLU THR THR LYS PRO SER SEQRES 14MM 212 LYS GLN SER ASN ASN LYS THR ALA ALA SER SER TYR LEU SEQRES 15MM 212 SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SEQRES 16MM 212 SER CYS GLN VAL THR HIS GLU GLY THR THR VAL GLU LYS SEQRES 17MM 212 THR VAL ALA PRO SEQRES 1NN 398 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2NN 398 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3NN 398 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4NN 398 ALA PRO GLY LYS GLY LEU GLN TRP VAL SER SER ILE SER SEQRES 5NN 398 SER SER SER THR TYR MET TYR TYR GLY ASP SER VAL LYS SEQRES 6NN 398 GLY ARG PHE THR ILE SER ARG ASP ASN ALA ARG ASN SER SEQRES 7NN 398 LEU TYR LEU GLN MET ASN SER LEU ARG VAL GLU ASP THR SEQRES 8NN 398 ALA VAL TYR TYR CYS ALA ARG TYR ALA HIS ASP TRP ASN SEQRES 9NN 398 VAL ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10NN 398 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11NN 398 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12NN 398 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13NN 398 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14NN 398 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15NN 398 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16NN 398 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17NN 398 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 18NN 398 ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO GLU SEQRES 19NN 398 LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO LYS SEQRES 20NN 398 PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU VAL SEQRES 21NN 398 THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO GLU SEQRES 22NN 398 VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL HIS SEQRES 23NN 398 ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SER SEQRES 24NN 398 THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS GLN SEQRES 25NN 398 ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SER SEQRES 26NN 398 ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SER SEQRES 27NN 398 LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR THR SEQRES 28NN 398 LEU PRO PRO SER ARG ASP GLU LEU THR LYS ASN GLN VAL SEQRES 29NN 398 SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER ASP SEQRES 30NN 398 ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU ASN SEQRES 31NN 398 ASN TYR LYS THR THR PRO PRO VAL SEQRES 1YY 398 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2YY 398 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3YY 398 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4YY 398 ALA PRO GLY LYS GLY LEU GLN TRP VAL SER SER ILE SER SEQRES 5YY 398 SER SER SER THR TYR MET TYR TYR GLY ASP SER VAL LYS SEQRES 6YY 398 GLY ARG PHE THR ILE SER ARG ASP ASN ALA ARG ASN SER SEQRES 7YY 398 LEU TYR LEU GLN MET ASN SER LEU ARG VAL GLU ASP THR SEQRES 8YY 398 ALA VAL TYR TYR CYS ALA ARG TYR ALA HIS ASP TRP ASN SEQRES 9YY 398 VAL ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SER SEQRES 10YY 398 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11YY 398 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12YY 398 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13YY 398 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14YY 398 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15YY 398 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16YY 398 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17YY 398 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 18YY 398 ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO GLU SEQRES 19YY 398 LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO LYS SEQRES 20YY 398 PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU VAL SEQRES 21YY 398 THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO GLU SEQRES 22YY 398 VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL HIS SEQRES 23YY 398 ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SER SEQRES 24YY 398 THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS GLN SEQRES 25YY 398 ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SER SEQRES 26YY 398 ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SER SEQRES 27YY 398 LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR THR SEQRES 28YY 398 LEU PRO PRO SER ARG ASP GLU LEU THR LYS ASN GLN VAL SEQRES 29YY 398 SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER ASP SEQRES 30YY 398 ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU ASN SEQRES 31YY 398 ASN TYR LYS THR THR PRO PRO VAL HELIX 1 AA1 ASNAA 73 LEUAA 77 5 5 HELIX 2 AA2 GLYAA 113 ASNAA 119 5 7 HELIX 3 AA3 THRAA 175 VALAA 180 5 6 HELIX 4 AA4 PROAA 196 GLUAA 198 5 3 HELIX 5 AA5 CYSAA 246 GLYAA 248 5 3 HELIX 6 AA6 THRBB 66 ASPBB 70 5 5 HELIX 7 AA7 ASNBB 73 LEUBB 77 5 5 HELIX 8 AA8 GLYBB 113 ASNBB 119 5 7 HELIX 9 AA9 THRBB 175 VALBB 180 5 6 HELIX 10 AB1 PROBB 196 GLUBB 198 5 3 HELIX 11 AB2 CYSBB 246 GLYBB 248 5 3 HELIX 12 AB3 THRCC 66 ASPCC 70 5 5 HELIX 13 AB4 ASNCC 73 LEUCC 77 5 5 HELIX 14 AB5 GLYCC 113 ASNCC 119 5 7 HELIX 15 AB6 THRCC 175 VALCC 180 5 6 HELIX 16 AB7 PROCC 196 GLUCC 198 5 3 HELIX 17 AB8 CYSCC 246 GLYCC 248 5 3 HELIX 18 AB9 THRDD 66 ASPDD 70 5 5 HELIX 19 AC1 ASNDD 73 LEUDD 77 5 5 HELIX 20 AC2 GLYDD 113 ASNDD 119 5 7 HELIX 21 AC3 THRDD 175 VALDD 180 5 6 HELIX 22 AC4 PRODD 196 GLUDD 198 5 3 HELIX 23 AC5 CYSDD 246 GLYDD 248 5 3 HELIX 24 AC6 THREE 66 ASPEE 70 5 5 HELIX 25 AC7 ASNEE 73 LEUEE 77 5 5 HELIX 26 AC8 GLYEE 113 ASNEE 119 5 7 HELIX 27 AC9 THREE 175 VALEE 180 5 6 HELIX 28 AD1 PROEE 196 GLUEE 198 5 3 HELIX 29 AD2 CYSEE 246 GLYEE 248 5 3 HELIX 30 AD3 GLNFF 80 GLUFF 84 5 5 HELIX 31 AD4 GLNGG 80 GLUGG 84 5 5 HELIX 32 AD5 THRHH 28 TYRHH 32 5 5 HELIX 33 AD6 GLNII 80 GLUII 84 5 5 HELIX 34 AD7 THRJJ 28 TYRJJ 32 5 5 HELIX 35 AD8 ASPJJ 62 LYSJJ 65 5 4 HELIX 36 AD9 HISJJ 210 ASNJJ 214 5 5 HELIX 37 AE1 GLNKK 80 GLUKK 84 5 5 HELIX 38 AE2 THRLL 28 TYRLL 32 5 5 HELIX 39 AE3 ASPLL 62 LYSLL 65 5 4 HELIX 40 AE4 ARGLL 87 THRLL 91 5 5 HELIX 41 AE5 HISLL 210 ASNLL 214 5 5 HELIX 42 AE6 GLNMM 80 GLUMM 84 5 5 HELIX 43 AE7 THRNN 28 TYRNN 32 5 5 HELIX 44 AE8 ASPNN 62 LYSNN 65 5 4 HELIX 45 AE9 ARGNN 87 THRNN 91 5 5 HELIX 46 AF1 THRYY 28 TYRYY 32 5 5 HELIX 47 AF2 ASPYY 62 LYSYY 65 5 4 HELIX 48 AF3 ARGYY 87 THRYY 91 5 5 HELIX 49 AF4 HISYY 210 ASNYY 214 5 5 SHEET 1 AA1 3 GLUAA 25 LYSAA 30 0 SHEET 2 AA1 3 SERAA 275 LYSAA 288 -1 O ARGAA 286 N GLUAA 28 SHEET 3 AA1 3 ILEAA 36 LEUAA 43 -1 N CYSAA 41 O PHEAA 278 SHEET 1 AA2 4 GLUAA 25 LYSAA 30 0 SHEET 2 AA2 4 SERAA 275 LYSAA 288 -1 O ARGAA 286 N GLUAA 28 SHEET 3 AA2 4 ILEAA 99 ILEAA 112 -1 N GLUAA 103 O ARGAA 283 SHEET 4 AA2 4 THRAA 234 VALAA 235 -1 O THRAA 234 N LEUAA 107 SHEET 1 AA3 3 SERAA 81 PROAA 86 0 SHEET 2 AA3 3 ASNAA 250 THRAA 263 -1 O LEUAA 251 N ILEAA 85 SHEET 3 AA3 3 GLNAA 269 GLYAA 273 -1 O GLNAA 270 N PHEAA 262 SHEET 1 AA4 5 SERAA 81 PROAA 86 0 SHEET 2 AA4 5 ASNAA 250 THRAA 263 -1 O LEUAA 251 N ILEAA 85 SHEET 3 AA4 5 SERAA 140 GLYAA 147 -1 N GLYAA 147 O TYRAA 252 SHEET 4 AA4 5 THRAA 210 THRAA 217 -1 O PHEAA 213 N PHEAA 144 SHEET 5 AA4 5 VALEE 225 THREE 229 -1 O LEUEE 226 N LEUAA 216 SHEET 1 AA5 3 LYSAA 186 LEUAA 189 0 SHEET 2 AA5 3 LEUAA 151 GLYAA 155 -1 N LEUAA 153 O ALAAA 187 SHEET 3 AA5 3 TRPAA 200 PROAA 202 -1 O VALAA 201 N GLNAA 154 SHEET 1 AA6 5 VALAA 225 THRAA 229 0 SHEET 2 AA6 5 THRBB 210 THRBB 217 -1 O GLYBB 214 N ILEAA 228 SHEET 3 AA6 5 SERBB 140 GLYBB 147 -1 N PHEBB 144 O PHEBB 213 SHEET 4 AA6 5 ASNBB 250 THRBB 263 -1 O TYRBB 252 N GLYBB 147 SHEET 5 AA6 5 SERBB 81 PROBB 86 -1 N ILEBB 85 O LEUBB 251 SHEET 1 AA7 5 VALAA 225 THRAA 229 0 SHEET 2 AA7 5 THRBB 210 THRBB 217 -1 O GLYBB 214 N ILEAA 228 SHEET 3 AA7 5 SERBB 140 GLYBB 147 -1 N PHEBB 144 O PHEBB 213 SHEET 4 AA7 5 ASNBB 250 THRBB 263 -1 O TYRBB 252 N GLYBB 147 SHEET 5 AA7 5 GLNBB 269 GLYBB 273 -1 O GLNBB 270 N PHEBB 262 SHEET 1 AA8 3 VALBB 26 LYSBB 30 0 SHEET 2 AA8 3 SERBB 275 VALBB 287 -1 O ARGBB 286 N GLUBB 28 SHEET 3 AA8 3 ILEBB 36 LEUBB 43 -1 N CYSBB 41 O PHEBB 278 SHEET 1 AA9 4 VALBB 26 LYSBB 30 0 SHEET 2 AA9 4 SERBB 275 VALBB 287 -1 O ARGBB 286 N GLUBB 28 SHEET 3 AA9 4 LEUBB 100 ILEBB 112 -1 N GLUBB 103 O ARGBB 283 SHEET 4 AA9 4 THRBB 234 VALBB 235 -1 O THRBB 234 N LEUBB 107 SHEET 1 AB1 3 LYSBB 186 LEUBB 189 0 SHEET 2 AB1 3 LEUBB 151 GLYBB 155 -1 N LEUBB 153 O ALABB 187 SHEET 3 AB1 3 TRPBB 200 PROBB 202 -1 O VALBB 201 N GLNBB 154 SHEET 1 AB2 5 VALBB 225 THRBB 229 0 SHEET 2 AB2 5 THRCC 210 THRCC 217 -1 O LEUCC 216 N LEUBB 226 SHEET 3 AB2 5 SERCC 140 GLYCC 147 -1 N HISCC 142 O THRCC 215 SHEET 4 AB2 5 ASNCC 250 THRCC 263 -1 O TYRCC 252 N GLYCC 147 SHEET 5 AB2 5 SERCC 81 PROCC 86 -1 N ILECC 85 O LEUCC 251 SHEET 1 AB3 5 VALBB 225 THRBB 229 0 SHEET 2 AB3 5 THRCC 210 THRCC 217 -1 O LEUCC 216 N LEUBB 226 SHEET 3 AB3 5 SERCC 140 GLYCC 147 -1 N HISCC 142 O THRCC 215 SHEET 4 AB3 5 ASNCC 250 THRCC 263 -1 O TYRCC 252 N GLYCC 147 SHEET 5 AB3 5 GLNCC 269 GLYCC 273 -1 O GLNCC 270 N PHECC 262 SHEET 1 AB4 3 VALCC 26 LYSCC 30 0 SHEET 2 AB4 3 SERCC 275 VALCC 287 -1 O ARGCC 286 N GLUCC 28 SHEET 3 AB4 3 ILECC 36 LEUCC 43 -1 N CYSCC 41 O PHECC 278 SHEET 1 AB5 4 VALCC 26 LYSCC 30 0 SHEET 2 AB5 4 SERCC 275 VALCC 287 -1 O ARGCC 286 N GLUCC 28 SHEET 3 AB5 4 LEUCC 100 ILECC 112 -1 N GLUCC 103 O ARGCC 283 SHEET 4 AB5 4 THRCC 234 VALCC 235 -1 O THRCC 234 N LEUCC 107 SHEET 1 AB6 3 LYSCC 186 TYRCC 188 0 SHEET 2 AB6 3 GLUCC 152 GLYCC 155 -1 N LEUCC 153 O ALACC 187 SHEET 3 AB6 3 TRPCC 200 PROCC 202 -1 O VALCC 201 N GLNCC 154 SHEET 1 AB7 5 VALCC 225 THRCC 229 0 SHEET 2 AB7 5 THRDD 210 THRDD 217 -1 O GLYDD 214 N ILECC 228 SHEET 3 AB7 5 SERDD 140 GLYDD 147 -1 N PHEDD 144 O PHEDD 213 SHEET 4 AB7 5 ASNDD 250 THRDD 263 -1 O TYRDD 252 N GLYDD 147 SHEET 5 AB7 5 SERDD 81 PRODD 86 -1 N ILEDD 85 O LEUDD 251 SHEET 1 AB8 5 VALCC 225 THRCC 229 0 SHEET 2 AB8 5 THRDD 210 THRDD 217 -1 O GLYDD 214 N ILECC 228 SHEET 3 AB8 5 SERDD 140 GLYDD 147 -1 N PHEDD 144 O PHEDD 213 SHEET 4 AB8 5 ASNDD 250 THRDD 263 -1 O TYRDD 252 N GLYDD 147 SHEET 5 AB8 5 GLNDD 269 GLYDD 273 -1 O GLNDD 270 N PHEDD 262 SHEET 1 AB9 3 GLUDD 25 LYSDD 30 0 SHEET 2 AB9 3 SERDD 275 LYSDD 288 -1 O ARGDD 286 N GLUDD 28 SHEET 3 AB9 3 ILEDD 36 LEUDD 43 -1 N CYSDD 41 O PHEDD 278 SHEET 1 AC1 4 GLUDD 25 LYSDD 30 0 SHEET 2 AC1 4 SERDD 275 LYSDD 288 -1 O ARGDD 286 N GLUDD 28 SHEET 3 AC1 4 ASNDD 98 ILEDD 112 -1 N GLUDD 103 O ARGDD 283 SHEET 4 AC1 4 THRDD 234 VALDD 235 -1 O THRDD 234 N LEUDD 107 SHEET 1 AC2 3 LYSDD 186 LEUDD 189 0 SHEET 2 AC2 3 LEUDD 151 GLYDD 155 -1 N LEUDD 153 O ALADD 187 SHEET 3 AC2 3 TRPDD 200 PRODD 202 -1 O VALDD 201 N GLNDD 154 SHEET 1 AC3 5 VALDD 225 THRDD 229 0 SHEET 2 AC3 5 THREE 210 THREE 217 -1 O LEUEE 216 N LEUDD 226 SHEET 3 AC3 5 SEREE 140 GLYEE 147 -1 N PHEEE 144 O PHEEE 213 SHEET 4 AC3 5 ASNEE 250 THREE 263 -1 O TYREE 252 N GLYEE 147 SHEET 5 AC3 5 SEREE 81 PROEE 86 -1 N ILEEE 85 O LEUEE 251 SHEET 1 AC4 5 VALDD 225 THRDD 229 0 SHEET 2 AC4 5 THREE 210 THREE 217 -1 O LEUEE 216 N LEUDD 226 SHEET 3 AC4 5 SEREE 140 GLYEE 147 -1 N PHEEE 144 O PHEEE 213 SHEET 4 AC4 5 ASNEE 250 THREE 263 -1 O TYREE 252 N GLYEE 147 SHEET 5 AC4 5 GLNEE 269 GLYEE 273 -1 O GLNEE 270 N PHEEE 262 SHEET 1 AC5 3 GLUEE 25 LYSEE 30 0 SHEET 2 AC5 3 SEREE 275 LYSEE 288 -1 O ARGEE 286 N LEUEE 27 SHEET 3 AC5 3 ILEEE 36 LEUEE 43 -1 N CYSEE 41 O PHEEE 278 SHEET 1 AC6 4 GLUEE 25 LYSEE 30 0 SHEET 2 AC6 4 SEREE 275 LYSEE 288 -1 O ARGEE 286 N LEUEE 27 SHEET 3 AC6 4 LEUEE 100 ILEEE 112 -1 N GLUEE 103 O ARGEE 283 SHEET 4 AC6 4 THREE 234 VALEE 235 -1 O THREE 234 N LEUEE 107 SHEET 1 AC7 3 LYSEE 186 LEUEE 189 0 SHEET 2 AC7 3 LEUEE 151 GLYEE 155 -1 N LEUEE 153 O ALAEE 187 SHEET 3 AC7 3 TRPEE 200 PROEE 202 -1 O VALEE 201 N GLNEE 154 SHEET 1 AC8 5 SERFF 9 GLYFF 12 0 SHEET 2 AC8 5 THRFF 105 VALFF 109 1 O THRFF 108 N ALAFF 10 SHEET 3 AC8 5 GLYFF 85 ASPFF 93 -1 N GLYFF 85 O LEUFF 107 SHEET 4 AC8 5 VALFF 34 GLNFF 39 -1 N PHEFF 37 O HISFF 88 SHEET 5 AC8 5 LYSFF 46 ILEFF 49 -1 O ILEFF 49 N TRPFF 36 SHEET 1 AC9 4 SERFF 9 GLYFF 12 0 SHEET 2 AC9 4 THRFF 105 VALFF 109 1 O THRFF 108 N ALAFF 10 SHEET 3 AC9 4 GLYFF 85 ASPFF 93 -1 N GLYFF 85 O LEUFF 107 SHEET 4 AC9 4 GLYFF 98 PHEFF 101 -1 O GLYFF 98 N ASPFF 93 SHEET 1 AD1 3 VALFF 18 SERFF 23 0 SHEET 2 AD1 3 SERFF 71 ILEFF 76 -1 O VALFF 72 N CYSFF 22 SHEET 3 AD1 3 PHEFF 63 SERFF 68 -1 N SERFF 64 O ALAFF 75 SHEET 1 AD2 4 THRFF 118 PHEFF 122 0 SHEET 2 AD2 4 ALAFF 134 PHEFF 143 -1 O VALFF 137 N PHEFF 122 SHEET 3 AD2 4 THRFF 176 LEUFF 184 -1 O LEUFF 184 N ALAFF 134 SHEET 4 AD2 4 VALFF 163 THRFF 165 -1 N GLUFF 164 O TYRFF 181 SHEET 1 AD3 4 THRFF 118 PHEFF 122 0 SHEET 2 AD3 4 ALAFF 134 PHEFF 143 -1 O VALFF 137 N PHEFF 122 SHEET 3 AD3 4 THRFF 176 LEUFF 184 -1 O LEUFF 184 N ALAFF 134 SHEET 4 AD3 4 SERFF 169 LYSFF 170 -1 N SERFF 169 O ALAFF 177 SHEET 1 AD4 2 SERFF 196 CYSFF 197 0 SHEET 2 AD4 2 LYSFF 208 THRFF 209 -1 O LYSFF 208 N CYSFF 197 SHEET 1 AD5 5 SERGG 9 GLYGG 12 0 SHEET 2 AD5 5 THRGG 105 VALGG 109 1 O THRGG 108 N ALAGG 10 SHEET 3 AD5 5 GLYGG 85 ASPGG 93 -1 N GLYGG 85 O LEUGG 107 SHEET 4 AD5 5 VALGG 34 GLNGG 39 -1 N PHEGG 37 O HISGG 88 SHEET 5 AD5 5 LYSGG 46 ILEGG 49 -1 O ILEGG 49 N TRPGG 36 SHEET 1 AD6 4 SERGG 9 GLYGG 12 0 SHEET 2 AD6 4 THRGG 105 VALGG 109 1 O THRGG 108 N ALAGG 10 SHEET 3 AD6 4 GLYGG 85 ASPGG 93 -1 N GLYGG 85 O LEUGG 107 SHEET 4 AD6 4 GLYGG 98 PHEGG 101 -1 O GLYGG 98 N ASPGG 93 SHEET 1 AD7 3 VALGG 18 SERGG 23 0 SHEET 2 AD7 3 SERGG 71 ILEGG 76 -1 O VALGG 72 N CYSGG 22 SHEET 3 AD7 3 PHEGG 63 SERGG 68 -1 N SERGG 64 O ALAGG 75 SHEET 1 AD8 4 THRGG 118 VALGG 119 0 SHEET 2 AD8 4 LEUGG 136 PHEGG 143 -1 O SERGG 141 N THRGG 118 SHEET 3 AD8 4 THRGG 176 LEUGG 182 -1 O THRGG 176 N PHEGG 143 SHEET 4 AD8 4 GLUGG 164 THRGG 165 -1 N GLUGG 164 O TYRGG 181 SHEET 1 AD9 4 THRGG 118 VALGG 119 0 SHEET 2 AD9 4 LEUGG 136 PHEGG 143 -1 O SERGG 141 N THRGG 118 SHEET 3 AD9 4 THRGG 176 LEUGG 182 -1 O THRGG 176 N PHEGG 143 SHEET 4 AD9 4 SERGG 169 LYSGG 170 -1 N SERGG 169 O ALAGG 177 SHEET 1 AE1 2 SERGG 196 CYSGG 197 0 SHEET 2 AE1 2 LYSGG 208 THRGG 209 -1 O LYSGG 208 N CYSGG 197 SHEET 1 AE2 4 GLNHH 3 SERHH 7 0 SHEET 2 AE2 4 LEUHH 18 SERHH 25 -1 O SERHH 21 N SERHH 7 SHEET 3 AE2 4 SERHH 78 METHH 83 -1 O METHH 83 N LEUHH 18 SHEET 4 AE2 4 PHEHH 68 ASPHH 73 -1 N SERHH 71 O TYRHH 80 SHEET 1 AE3 6 LEUHH 11 VALHH 12 0 SHEET 2 AE3 6 THRHH 112 VALHH 116 1 O THRHH 115 N VALHH 12 SHEET 3 AE3 6 ALAHH 92 ALAHH 100 -1 N TYRHH 94 O THRHH 112 SHEET 4 AE3 6 THRHH 33 GLNHH 39 -1 N ASNHH 35 O ALAHH 97 SHEET 5 AE3 6 LEUHH 45 ILEHH 51 -1 O GLNHH 46 N ARGHH 38 SHEET 6 AE3 6 METHH 58 TYRHH 60 -1 O TYRHH 59 N SERHH 50 SHEET 1 AE4 4 LEUHH 11 VALHH 12 0 SHEET 2 AE4 4 THRHH 112 VALHH 116 1 O THRHH 115 N VALHH 12 SHEET 3 AE4 4 ALAHH 92 ALAHH 100 -1 N TYRHH 94 O THRHH 112 SHEET 4 AE4 4 ASNHH 104 TRPHH 108 -1 O ASNHH 104 N ALAHH 100 SHEET 1 AE5 2 PHEHH 176 LEUHH 180 0 SHEET 2 AE5 2 TYRHH 186 SERHH 189 -1 O SERHH 189 N PHEHH 176 SHEET 1 AE6 5 SERII 9 GLYII 12 0 SHEET 2 AE6 5 THRII 105 VALII 109 1 O THRII 108 N ALAII 10 SHEET 3 AE6 5 GLYII 85 ASPII 93 -1 N GLYII 85 O LEUII 107 SHEET 4 AE6 5 VALII 34 GLNII 39 -1 N PHEII 37 O HISII 88 SHEET 5 AE6 5 LYSII 46 ILEII 49 -1 O ILEII 49 N TRPII 36 SHEET 1 AE7 4 SERII 9 GLYII 12 0 SHEET 2 AE7 4 THRII 105 VALII 109 1 O THRII 108 N ALAII 10 SHEET 3 AE7 4 GLYII 85 ASPII 93 -1 N GLYII 85 O LEUII 107 SHEET 4 AE7 4 GLYII 98 PHEII 101 -1 O GLYII 98 N ASPII 93 SHEET 1 AE8 3 VALII 18 SERII 23 0 SHEET 2 AE8 3 SERII 71 ILEII 76 -1 O VALII 72 N CYSII 22 SHEET 3 AE8 3 PHEII 63 SERII 68 -1 N SERII 64 O ALAII 75 SHEET 1 AE9 2 THRII 166 LYSII 167 0 SHEET 2 AE9 2 SERII 179 SERII 180 -1 O SERII 179 N LYSII 167 SHEET 1 AF1 4 GLNJJ 3 SERJJ 7 0 SHEET 2 AF1 4 LEUJJ 18 SERJJ 25 -1 O SERJJ 21 N SERJJ 7 SHEET 3 AF1 4 SERJJ 78 METJJ 83 -1 O METJJ 83 N LEUJJ 18 SHEET 4 AF1 4 PHEJJ 68 ASPJJ 73 -1 N SERJJ 71 O TYRJJ 80 SHEET 1 AF2 6 LEUJJ 11 VALJJ 12 0 SHEET 2 AF2 6 THRJJ 112 VALJJ 116 1 O THRJJ 115 N VALJJ 12 SHEET 3 AF2 6 ALAJJ 92 ALAJJ 100 -1 N TYRJJ 94 O THRJJ 112 SHEET 4 AF2 6 THRJJ 33 GLNJJ 39 -1 N VALJJ 37 O TYRJJ 95 SHEET 5 AF2 6 GLNJJ 46 ILEJJ 51 -1 O GLNJJ 46 N ARGJJ 38 SHEET 6 AF2 6 METJJ 58 TYRJJ 60 -1 O TYRJJ 59 N SERJJ 50 SHEET 1 AF3 4 LEUJJ 11 VALJJ 12 0 SHEET 2 AF3 4 THRJJ 112 VALJJ 116 1 O THRJJ 115 N VALJJ 12 SHEET 3 AF3 4 ALAJJ 92 ALAJJ 100 -1 N TYRJJ 94 O THRJJ 112 SHEET 4 AF3 4 ASNJJ 104 TRPJJ 108 -1 O ASNJJ 104 N ALAJJ 100 SHEET 1 AF4 4 SERJJ 125 VALJJ 126 0 SHEET 2 AF4 4 CYSJJ 150 TYRJJ 155 -1 O LYSJJ 153 N SERJJ 125 SHEET 3 AF4 4 TYRJJ 186 SERJJ 190 -1 O LEUJJ 188 N VALJJ 152 SHEET 4 AF4 4 VALJJ 179 LEUJJ 180 -1 N VALJJ 179 O SERJJ 187 SHEET 1 AF5 2 THRJJ 161 SERJJ 163 0 SHEET 2 AF5 2 ASNJJ 207 ASNJJ 209 -1 O ASNJJ 207 N SERJJ 163 SHEET 1 AF6 5 SERKK 9 GLYKK 12 0 SHEET 2 AF6 5 THRKK 105 VALKK 109 1 O THRKK 108 N ALAKK 10 SHEET 3 AF6 5 GLYKK 85 ASPKK 93 -1 N GLYKK 85 O LEUKK 107 SHEET 4 AF6 5 ASNKK 35 GLNKK 39 -1 N PHEKK 37 O HISKK 88 SHEET 5 AF6 5 LYSKK 46 ILEKK 49 -1 O ILEKK 49 N TRPKK 36 SHEET 1 AF7 4 SERKK 9 GLYKK 12 0 SHEET 2 AF7 4 THRKK 105 VALKK 109 1 O THRKK 108 N ALAKK 10 SHEET 3 AF7 4 GLYKK 85 ASPKK 93 -1 N GLYKK 85 O LEUKK 107 SHEET 4 AF7 4 GLYKK 98 PHEKK 101 -1 O GLYKK 98 N ASPKK 93 SHEET 1 AF8 3 VALKK 18 SERKK 23 0 SHEET 2 AF8 3 SERKK 71 ILEKK 76 -1 O VALKK 72 N CYSKK 22 SHEET 3 AF8 3 PHEKK 63 SERKK 68 -1 N SERKK 64 O ALAKK 75 SHEET 1 AF9 4 GLNLL 3 SERLL 7 0 SHEET 2 AF9 4 LEULL 18 SERLL 25 -1 O SERLL 21 N SERLL 7 SHEET 3 AF9 4 SERLL 78 METLL 83 -1 O METLL 83 N LEULL 18 SHEET 4 AF9 4 PHELL 68 ASPLL 73 -1 N SERLL 71 O TYRLL 80 SHEET 1 AG1 6 LEULL 11 VALLL 12 0 SHEET 2 AG1 6 THRLL 112 VALLL 116 1 O THRLL 115 N VALLL 12 SHEET 3 AG1 6 ALALL 92 ALALL 100 -1 N TYRLL 94 O THRLL 112 SHEET 4 AG1 6 THRLL 33 GLNLL 39 -1 N ASNLL 35 O ALALL 97 SHEET 5 AG1 6 GLNLL 46 ILELL 51 -1 O GLNLL 46 N ARGLL 38 SHEET 6 AG1 6 METLL 58 TYRLL 60 -1 O TYRLL 59 N SERLL 50 SHEET 1 AG2 4 LEULL 11 VALLL 12 0 SHEET 2 AG2 4 THRLL 112 VALLL 116 1 O THRLL 115 N VALLL 12 SHEET 3 AG2 4 ALALL 92 ALALL 100 -1 N TYRLL 94 O THRLL 112 SHEET 4 AG2 4 ASNLL 104 TRPLL 108 -1 O ASNLL 104 N ALALL 100 SHEET 1 AG3 3 LEULL 151 TYRLL 155 0 SHEET 2 AG3 3 TYRLL 186 SERLL 189 -1 O TYRLL 186 N TYRLL 155 SHEET 3 AG3 3 VALLL 179 LEULL 180 -1 N VALLL 179 O SERLL 187 SHEET 1 AG4 5 SERMM 9 SERMM 11 0 SHEET 2 AG4 5 THRMM 105 THRMM 108 1 O THRMM 108 N ALAMM 10 SHEET 3 AG4 5 GLYMM 85 ASPMM 93 -1 N GLYMM 85 O LEUMM 107 SHEET 4 AG4 5 VALMM 34 GLNMM 39 -1 N PHEMM 37 O HISMM 88 SHEET 5 AG4 5 LYSMM 46 ILEMM 49 -1 O ILEMM 49 N TRPMM 36 SHEET 1 AG5 4 SERMM 9 SERMM 11 0 SHEET 2 AG5 4 THRMM 105 THRMM 108 1 O THRMM 108 N ALAMM 10 SHEET 3 AG5 4 GLYMM 85 ASPMM 93 -1 N GLYMM 85 O LEUMM 107 SHEET 4 AG5 4 GLYMM 98 PHEMM 101 -1 O GLYMM 98 N ASPMM 93 SHEET 1 AG6 3 VALMM 18 SERMM 23 0 SHEET 2 AG6 3 SERMM 71 ILEMM 76 -1 O VALMM 72 N CYSMM 22 SHEET 3 AG6 3 PHEMM 63 SERMM 68 -1 N SERMM 64 O ALAMM 75 SHEET 1 AG7 4 GLNNN 3 SERNN 7 0 SHEET 2 AG7 4 LEUNN 18 SERNN 25 -1 O SERNN 21 N SERNN 7 SHEET 3 AG7 4 SERNN 78 METNN 83 -1 O METNN 83 N LEUNN 18 SHEET 4 AG7 4 PHENN 68 ASPNN 73 -1 N SERNN 71 O TYRNN 80 SHEET 1 AG8 6 LEUNN 11 VALNN 12 0 SHEET 2 AG8 6 THRNN 112 VALNN 116 1 O THRNN 115 N VALNN 12 SHEET 3 AG8 6 ALANN 92 ALANN 100 -1 N TYRNN 94 O THRNN 112 SHEET 4 AG8 6 METNN 34 GLNNN 39 -1 N ASNNN 35 O ALANN 97 SHEET 5 AG8 6 GLNNN 46 ILENN 51 -1 O GLNNN 46 N ARGNN 38 SHEET 6 AG8 6 METNN 58 TYRNN 60 -1 O TYRNN 59 N SERNN 50 SHEET 1 AG9 4 LEUNN 11 VALNN 12 0 SHEET 2 AG9 4 THRNN 112 VALNN 116 1 O THRNN 115 N VALNN 12 SHEET 3 AG9 4 ALANN 92 ALANN 100 -1 N TYRNN 94 O THRNN 112 SHEET 4 AG9 4 ASNNN 104 TRPNN 108 -1 O ASNNN 104 N ALANN 100 SHEET 1 AH1 4 GLNYY 3 SERYY 7 0 SHEET 2 AH1 4 LEUYY 18 SERYY 25 -1 O SERYY 21 N SERYY 7 SHEET 3 AH1 4 SERYY 78 METYY 83 -1 O METYY 83 N LEUYY 18 SHEET 4 AH1 4 PHEYY 68 ASPYY 73 -1 N SERYY 71 O TYRYY 80 SHEET 1 AH2 6 LEUYY 11 VALYY 12 0 SHEET 2 AH2 6 THRYY 112 VALYY 116 1 O THRYY 115 N VALYY 12 SHEET 3 AH2 6 ALAYY 92 ALAYY 100 -1 N TYRYY 94 O THRYY 112 SHEET 4 AH2 6 THRYY 33 GLNYY 39 -1 N ASNYY 35 O ALAYY 97 SHEET 5 AH2 6 LEUYY 45 ILEYY 51 -1 O GLNYY 46 N ARGYY 38 SHEET 6 AH2 6 METYY 58 TYRYY 60 -1 O TYRYY 59 N SERYY 50 SHEET 1 AH3 4 LEUYY 11 VALYY 12 0 SHEET 2 AH3 4 THRYY 112 VALYY 116 1 O THRYY 115 N VALYY 12 SHEET 3 AH3 4 ALAYY 92 ALAYY 100 -1 N TYRYY 94 O THRYY 112 SHEET 4 AH3 4 ASNYY 104 TRPYY 108 -1 O ASNYY 104 N ALAYY 100 SHEET 1 AH4 4 SERYY 125 LEUYY 129 0 SHEET 2 AH4 4 GLYYY 149 TYRYY 155 -1 O LYSYY 153 N SERYY 125 SHEET 3 AH4 4 TYRYY 186 VALYY 191 -1 O TYRYY 186 N TYRYY 155 SHEET 4 AH4 4 HISYY 174 THRYY 175 -1 N HISYY 174 O VALYY 191 SHEET 1 AH5 4 SERYY 125 LEUYY 129 0 SHEET 2 AH5 4 GLYYY 149 TYRYY 155 -1 O LYSYY 153 N SERYY 125 SHEET 3 AH5 4 TYRYY 186 VALYY 191 -1 O TYRYY 186 N TYRYY 155 SHEET 4 AH5 4 VALYY 179 LEUYY 180 -1 N VALYY 179 O SERYY 187 SHEET 1 AH6 2 THRYY 161 SERYY 163 0 SHEET 2 AH6 2 ASNYY 207 ASNYY 209 -1 O ASNYY 207 N SERYY 163 SSBOND 1 CYSFF 22 CYSFF 89 1555 1555 2.11 SSBOND 2 CYSFF 138 CYSFF 197 1555 1555 2.07 SSBOND 3 CYSGG 22 CYSGG 89 1555 1555 2.04 SSBOND 4 CYSGG 138 CYSGG 197 1555 1555 2.04 SSBOND 5 CYSHH 22 CYSHH 96 1555 1555 2.26 SSBOND 6 CYSII 22 CYSII 89 1555 1555 2.21 SSBOND 7 CYSJJ 22 CYSJJ 96 1555 1555 2.25 SSBOND 8 CYSJJ 150 CYSJJ 206 1555 1555 2.07 SSBOND 9 CYSKK 22 CYSKK 89 1555 1555 2.10 SSBOND 10 CYSLL 22 CYSLL 96 1555 1555 2.25 SSBOND 11 CYSMM 22 CYSMM 89 1555 1555 2.13 SSBOND 12 CYSNN 22 CYSNN 96 1555 1555 2.15 SSBOND 13 CYSYY 22 CYSYY 96 1555 1555 2.03 SSBOND 14 CYSYY 150 CYSYY 206 1555 1555 2.02 CISPEP 1 PHEJJ 156 PROJJ 157 0 -9.89 CISPEP 2 PHELL 156 PROLL 157 0 -10.44 CISPEP 3 PHEYY 156 PROYY 157 0 -9.28 CRYST1 137.070 110.440 158.210 90.00 93.12 90.00 P 1 21 1 10 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.007296 0.000000 0.000397 0.00000 SCALE2 0.000000 0.009055 0.000000 0.00000 SCALE3 0.000000 0.000000 0.006330 0.00000