HEADER VIRAL PROTEIN 29-JUL-21 7PAA TITLE JC POLYOMAVIRUS VP1 IN COMPLEX WITH SCFV 29B1 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SCFV 29B1; COMPND 3 CHAIN: ZZZ, KKK, aaa, bbb, ccc, ddd, eee, WWW, XXX, YYY; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: MAJOR CAPSID PROTEIN VP1; COMPND 7 CHAIN: AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH, III, JJJ; COMPND 8 FRAGMENT: UNP RESIDUES 23-290; COMPND 9 SYNONYM: MAJOR STRUCTURAL PROTEIN VP1; COMPND 10 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: JC POLYOMAVIRUS; SOURCE 9 ORGANISM_TAXID: 10632; SOURCE 10 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS ANTIBODY, POLYOMAVIRUS, VP1, NEUTRALIZATION, VIRAL PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR C.HARPRECHT,L.J.STROEH,J.FREYTAG,T.STEHLE JRNL AUTH C.HARPRECHT,L.J.STROEH,L.SENN,B.A.O'HARA,F.NAGEL,J.FREYTAG, JRNL AUTH 2 Y.D.STIEHROF,W.J.ATWOOD,B.COMBALUZIER,T.STEHLE JRNL TITL STRUCTURAL CHARACTERIZATION OF HUMAN NEUTRALIZING ANTIBODIES JRNL TITL 2 AGAINST JC AND BK POLYOMAVIRUS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0258 REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, REMARK 3 : NICHOLLS,WINN,LONG,VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : NULL REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.10 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 48.51 REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 99.9 REMARK 3 NUMBER OF REFLECTIONS : 117609 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : FREE R-VALUE REMARK 3 FREE R VALUE TEST SET SELECTION : NULL REMARK 3 R VALUE (WORKING + TEST SET) : NULL REMARK 3 R VALUE (WORKING SET) : 0.225 REMARK 3 FREE R VALUE : 0.240 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000 REMARK 3 FREE R VALUE TEST SET COUNT : 5881 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 3.10 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 3.18 REMARK 3 REFLECTION IN BIN (WORKING SET) : 8206 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 99.54 REMARK 3 BIN R VALUE (WORKING SET) : 0.3230 REMARK 3 BIN FREE R VALUE SET COUNT : 432 REMARK 3 BIN FREE R VALUE : 0.3350 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 37635 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 0 REMARK 3 SOLVENT ATOMS : 23 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 44.61 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : 1.33100 REMARK 3 B22 (A**2) : 0.48900 REMARK 3 B33 (A**2) : -1.29600 REMARK 3 B12 (A**2) : 0.00000 REMARK 3 B13 (A**2) : -0.67500 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): NULL REMARK 3 ESU BASED ON FREE R VALUE (A): 0.441 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): NULL REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.885 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.869 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 38800 ; 0.005 ; 0.013 REMARK 3 BOND LENGTHS OTHERS (A): 34362 ; 0.036 ; 0.017 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 52867 ; 1.296 ; 1.647 REMARK 3 BOND ANGLES OTHERS (DEGREES): 79813 ; 2.394 ; 1.573 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 4978 ; 7.218 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 1954 ;34.279 ;22.093 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 5967 ;15.381 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 240 ;12.846 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 5038 ; 0.049 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 44244 ; 0.004 ; 0.020 REMARK 3 GENERAL PLANES OTHERS (A): 8344 ; 0.004 ; 0.020 REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): 5838 ; 0.181 ; 0.200 REMARK 3 NON-BONDED CONTACTS OTHERS (A): 129 ; 0.418 ; 0.200 REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): 18054 ; 0.158 ; 0.200 REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): 606 ; 0.118 ; 0.200 REMARK 3 H-BOND (X...Y) OTHERS (A): 1 ; 0.208 ; 0.200 REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 19756 ; 2.659 ; 4.941 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 19755 ; 2.659 ; 4.941 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 24648 ; 4.140 ; 7.404 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): 24649 ; 4.140 ; 7.404 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 19044 ; 1.474 ; 4.859 REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): 19045 ; 1.474 ; 4.859 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 28173 ; 2.517 ; 7.274 REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): 28174 ; 2.517 ; 7.274 REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK BULK SOLVENT REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THEIR REMARK 3 RIDING POSITIONS REMARK 4 REMARK 4 7PAA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE. REMARK 100 THE DEPOSITION ID IS D_1292115685. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 24-OCT-16 REMARK 200 TEMPERATURE (KELVIN) : 93 REMARK 200 PH : NULL REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SLS REMARK 200 BEAMLINE : X06DA REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.9794 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS 2M-F REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : XDS REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 129715 REMARK 200 RESOLUTION RANGE HIGH (A) : 3.000 REMARK 200 RESOLUTION RANGE LOW (A) : 48.500 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.8 REMARK 200 DATA REDUNDANCY : 7.060 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 10.3700 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.18 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : NULL REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 2.210 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: 3NXG, 4KQ3 REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 57.63 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.90 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M TRIMETHANOLAMINE N-OXIDE, 0.1 M REMARK 280 TRIS (PH 8.5), 20% PEG 2000, VAPOR DIFFUSION, SITTING DROP, REMARK 280 TEMPERATURE 277.15K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 86.26500 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1, 2 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: ZZZ, AAA, BBB, CCC, DDD, EEE, REMARK 350 AND CHAINS: KKK, WWW, XXX, YYY REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 350 REMARK 350 BIOMOLECULE: 2 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: FFF, GGG, HHH, III, JJJ, aaa, REMARK 350 AND CHAINS: bbb, ccc, ddd, eee REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 LEU Z 1111A REMARK 465 GLY Z 1111B REMARK 465 SER Z 1111C REMARK 465 THR Z 1111D REMARK 465 SER Z 1111E REMARK 465 GLY Z 1111F REMARK 465 SER Z 1111G REMARK 465 GLY Z 1111H REMARK 465 LYS Z 1111I REMARK 465 PRO Z 1111J REMARK 465 GLY Z 1111K REMARK 465 SER Z 1111L REMARK 465 GLY Z 1111M REMARK 465 GLU Z 1111N REMARK 465 GLY Z 1111O REMARK 465 SER Z 1111P REMARK 465 THR Z 1111Q REMARK 465 LYS Z 1111R REMARK 465 SER Z 1247 REMARK 465 SER Z 1248 REMARK 465 GLY A 18 REMARK 465 SER A 19 REMARK 465 HIS A 20 REMARK 465 MET A 21 REMARK 465 GLY A 22 REMARK 465 GLY A 23 REMARK 465 GLY A 97 REMARK 465 ASN A 98 REMARK 465 GLY B 18 REMARK 465 SER B 19 REMARK 465 HIS B 20 REMARK 465 MET B 21 REMARK 465 GLY B 22 REMARK 465 GLY B 23 REMARK 465 ASP B 93 REMARK 465 LEU B 94 REMARK 465 THR B 95 REMARK 465 CYS B 96 REMARK 465 GLY B 97 REMARK 465 ASN B 98 REMARK 465 ASN B 289 REMARK 465 GLY C 18 REMARK 465 SER C 19 REMARK 465 HIS C 20 REMARK 465 MET C 21 REMARK 465 GLY C 22 REMARK 465 GLY C 23 REMARK 465 VAL C 24 REMARK 465 GLU C 92 REMARK 465 ASP C 93 REMARK 465 LEU C 94 REMARK 465 THR C 95 REMARK 465 CYS C 96 REMARK 465 GLY C 97 REMARK 465 GLY D 18 REMARK 465 SER D 19 REMARK 465 HIS D 20 REMARK 465 MET D 21 REMARK 465 GLY D 22 REMARK 465 GLY D 23 REMARK 465 GLU D 92 REMARK 465 ASP D 93 REMARK 465 LEU D 94 REMARK 465 THR D 95 REMARK 465 CYS D 96 REMARK 465 GLY D 97 REMARK 465 ASN D 98 REMARK 465 GLY E 18 REMARK 465 SER E 19 REMARK 465 HIS E 20 REMARK 465 MET E 21 REMARK 465 GLY E 22 REMARK 465 GLY E 23 REMARK 465 GLU E 92 REMARK 465 ASP E 93 REMARK 465 LEU E 94 REMARK 465 THR E 95 REMARK 465 CYS E 96 REMARK 465 GLY E 97 REMARK 465 ASN E 98 REMARK 465 GLY F 18 REMARK 465 SER F 19 REMARK 465 HIS F 20 REMARK 465 MET F 21 REMARK 465 GLY F 22 REMARK 465 GLY F 23 REMARK 465 GLU F 92 REMARK 465 ASP F 93 REMARK 465 LEU F 94 REMARK 465 THR F 95 REMARK 465 CYS F 96 REMARK 465 GLY F 97 REMARK 465 ASN F 98 REMARK 465 GLY G 18 REMARK 465 SER G 19 REMARK 465 HIS G 20 REMARK 465 MET G 21 REMARK 465 GLY G 22 REMARK 465 GLY G 23 REMARK 465 GLU G 92 REMARK 465 ASP G 93 REMARK 465 LEU G 94 REMARK 465 THR G 95 REMARK 465 CYS G 96 REMARK 465 GLY G 97 REMARK 465 ASN G 98 REMARK 465 ASN G 289 REMARK 465 GLY H 18 REMARK 465 SER H 19 REMARK 465 HIS H 20 REMARK 465 MET H 21 REMARK 465 GLY H 22 REMARK 465 GLY H 23 REMARK 465 VAL H 24 REMARK 465 GLU H 92 REMARK 465 ASP H 93 REMARK 465 LEU H 94 REMARK 465 THR H 95 REMARK 465 CYS H 96 REMARK 465 GLY H 97 REMARK 465 ASN H 98 REMARK 465 GLY I 18 REMARK 465 SER I 19 REMARK 465 HIS I 20 REMARK 465 MET I 21 REMARK 465 GLY I 22 REMARK 465 GLY I 23 REMARK 465 GLU I 92 REMARK 465 ASP I 93 REMARK 465 LEU I 94 REMARK 465 THR I 95 REMARK 465 CYS I 96 REMARK 465 GLY I 97 REMARK 465 ASN I 98 REMARK 465 GLY J 18 REMARK 465 SER J 19 REMARK 465 HIS J 20 REMARK 465 MET J 21 REMARK 465 GLY J 22 REMARK 465 GLY J 23 REMARK 465 GLU J 92 REMARK 465 ASP J 93 REMARK 465 LEU J 94 REMARK 465 THR J 95 REMARK 465 CYS J 96 REMARK 465 GLY J 97 REMARK 465 ASN J 98 REMARK 465 LEU K 1111A REMARK 465 GLY K 1111B REMARK 465 SER K 1111C REMARK 465 THR K 1111D REMARK 465 SER K 1111E REMARK 465 GLY K 1111F REMARK 465 SER K 1111G REMARK 465 GLY K 1111H REMARK 465 LYS K 1111I REMARK 465 PRO K 1111J REMARK 465 GLY K 1111K REMARK 465 SER K 1111L REMARK 465 GLY K 1111M REMARK 465 GLU K 1111N REMARK 465 GLY K 1111O REMARK 465 SER K 1111P REMARK 465 THR K 1111Q REMARK 465 LYS K 1111R REMARK 465 SER K 1247 REMARK 465 SER K 1248 REMARK 465 SER a 1115A REMARK 465 GLY a 1115B REMARK 465 SER a 1115C REMARK 465 GLY a 1115D REMARK 465 LYS a 1115E REMARK 465 PRO a 1115F REMARK 465 GLY a 1115G REMARK 465 SER a 1115H REMARK 465 GLY a 1115I REMARK 465 GLU a 1115J REMARK 465 GLY a 1115K REMARK 465 SER a 1115L REMARK 465 THR a 1115M REMARK 465 LYS a 1115N REMARK 465 SER a 1247 REMARK 465 SER a 1248 REMARK 465 LEU b 1111A REMARK 465 GLY b 1111B REMARK 465 SER b 1111C REMARK 465 THR b 1111D REMARK 465 SER b 1111E REMARK 465 GLY b 1111F REMARK 465 SER b 1111G REMARK 465 GLY b 1111H REMARK 465 LYS b 1111I REMARK 465 PRO b 1111J REMARK 465 GLY b 1111K REMARK 465 SER b 1111L REMARK 465 GLY b 1111M REMARK 465 GLU b 1111N REMARK 465 GLY b 1111O REMARK 465 SER b 1111P REMARK 465 THR b 1111Q REMARK 465 LYS b 1111R REMARK 465 SER b 1247 REMARK 465 SER b 1248 REMARK 465 SER c 1113A REMARK 465 THR c 1113B REMARK 465 SER c 1113C REMARK 465 GLY c 1113D REMARK 465 SER c 1113E REMARK 465 GLY c 1113F REMARK 465 LYS c 1113G REMARK 465 PRO c 1113H REMARK 465 GLY c 1113I REMARK 465 SER c 1113J REMARK 465 GLY c 1113K REMARK 465 GLU c 1113L REMARK 465 GLY c 1113M REMARK 465 SER c 1113N REMARK 465 THR c 1113O REMARK 465 LYS c 1113P REMARK 465 SER c 1247 REMARK 465 SER c 1248 REMARK 465 GLY d 1112A REMARK 465 SER d 1112B REMARK 465 THR d 1112C REMARK 465 SER d 1112D REMARK 465 GLY d 1112E REMARK 465 SER d 1112F REMARK 465 GLY d 1112G REMARK 465 LYS d 1112H REMARK 465 PRO d 1112I REMARK 465 GLY d 1112J REMARK 465 SER d 1112K REMARK 465 GLY d 1112L REMARK 465 GLU d 1112M REMARK 465 GLY d 1112N REMARK 465 SER d 1112O REMARK 465 THR d 1112P REMARK 465 LYS d 1112Q REMARK 465 SER d 1247 REMARK 465 SER d 1248 REMARK 465 THR e 1114A REMARK 465 SER e 1114B REMARK 465 GLY e 1114C REMARK 465 SER e 1114D REMARK 465 GLY e 1114E REMARK 465 LYS e 1114F REMARK 465 PRO e 1114G REMARK 465 GLY e 1114H REMARK 465 SER e 1114I REMARK 465 GLY e 1114J REMARK 465 GLU e 1114K REMARK 465 GLY e 1114L REMARK 465 SER e 1114M REMARK 465 THR e 1114N REMARK 465 LYS e 1114O REMARK 465 SER e 1247 REMARK 465 SER e 1248 REMARK 465 SER W 1115A REMARK 465 GLY W 1115B REMARK 465 SER W 1115C REMARK 465 GLY W 1115D REMARK 465 LYS W 1115E REMARK 465 PRO W 1115F REMARK 465 GLY W 1115G REMARK 465 SER W 1115H REMARK 465 GLY W 1115I REMARK 465 GLU W 1115J REMARK 465 GLY W 1115K REMARK 465 SER W 1115L REMARK 465 THR W 1115M REMARK 465 LYS W 1115N REMARK 465 SER W 1247 REMARK 465 SER W 1248 REMARK 465 VAL X 1108A REMARK 465 THR X 1108B REMARK 465 VAL X 1108C REMARK 465 LEU X 1108D REMARK 465 GLY X 1108E REMARK 465 SER X 1108F REMARK 465 THR X 1108G REMARK 465 SER X 1108H REMARK 465 GLY X 1108I REMARK 465 SER X 1108J REMARK 465 GLY X 1108K REMARK 465 LYS X 1108L REMARK 465 PRO X 1108M REMARK 465 GLY X 1108N REMARK 465 SER X 1108O REMARK 465 GLY X 1108P REMARK 465 GLU X 1108Q REMARK 465 GLY X 1108R REMARK 465 SER X 1108S REMARK 465 THR X 1108T REMARK 465 LYS X 1108U REMARK 465 SER X 1247 REMARK 465 SER X 1248 REMARK 465 SER Y 1113A REMARK 465 THR Y 1113B REMARK 465 SER Y 1113C REMARK 465 GLY Y 1113D REMARK 465 SER Y 1113E REMARK 465 GLY Y 1113F REMARK 465 LYS Y 1113G REMARK 465 PRO Y 1113H REMARK 465 GLY Y 1113I REMARK 465 SER Y 1113J REMARK 465 GLY Y 1113K REMARK 465 GLU Y 1113L REMARK 465 GLY Y 1113M REMARK 465 SER Y 1113N REMARK 465 THR Y 1113O REMARK 465 LYS Y 1113P REMARK 465 SER Y 1247 REMARK 465 SER Y 1248 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS Z1019 CG CD CE NZ REMARK 470 SER Z1058 OG REMARK 470 ARG Z1079 CG CD NE CZ NH1 NH2 REMARK 470 ARG Z1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU Z1125 CG CD OE1 OE2 REMARK 470 LEU Z1135 CG CD1 CD2 REMARK 470 LYS Z1167 CG CD CE NZ REMARK 470 LYS Z1200 CD CE NZ REMARK 470 ARG Z1211 CG CD NE CZ NH1 NH2 REMARK 470 VAL A 24 CG1 CG2 REMARK 470 GLU A 25 CG CD OE1 OE2 REMARK 470 THR A 95 OG1 CG2 REMARK 470 ASN A 289 CG OD1 ND2 REMARK 470 VAL B 24 CG1 CG2 REMARK 470 ASN B 91 CG OD1 ND2 REMARK 470 GLU B 92 CG CD OE1 OE2 REMARK 470 GLU C 25 CG CD OE1 OE2 REMARK 470 VAL C 33 CG1 CG2 REMARK 470 ASN C 91 CG OD1 ND2 REMARK 470 ASN C 98 CG OD1 ND2 REMARK 470 ASN C 289 CG OD1 ND2 REMARK 470 VAL D 24 CG1 CG2 REMARK 470 GLU D 25 CG CD OE1 OE2 REMARK 470 ASN D 91 CG OD1 ND2 REMARK 470 ASN D 289 CG OD1 ND2 REMARK 470 VAL E 24 CG1 CG2 REMARK 470 ASN E 91 CG OD1 ND2 REMARK 470 ASN E 289 CG OD1 ND2 REMARK 470 VAL F 24 CG1 CG2 REMARK 470 GLU F 25 CG CD OE1 OE2 REMARK 470 ASN F 91 CG OD1 ND2 REMARK 470 ASN F 289 CG OD1 ND2 REMARK 470 VAL G 24 CG1 CG2 REMARK 470 ASN G 91 CG OD1 ND2 REMARK 470 GLU H 25 CG CD OE1 OE2 REMARK 470 VAL H 33 CG1 CG2 REMARK 470 ASN H 91 CG OD1 ND2 REMARK 470 ASN H 289 CG OD1 ND2 REMARK 470 VAL I 24 CG1 CG2 REMARK 470 GLU I 25 CG CD OE1 OE2 REMARK 470 ASN I 91 CG OD1 ND2 REMARK 470 ASN I 289 CG OD1 ND2 REMARK 470 VAL J 24 CG1 CG2 REMARK 470 ASN J 289 CG OD1 ND2 REMARK 470 LYS K1019 CG CD CE NZ REMARK 470 SER K1058 OG REMARK 470 ARG K1079 CG CD NE CZ NH1 NH2 REMARK 470 GLU K1125 CG CD OE1 OE2 REMARK 470 LYS K1167 CG CD CE NZ REMARK 470 LYS K1200 CD CE NZ REMARK 470 LYS a1019 CG CD CE NZ REMARK 470 SER a1058 OG REMARK 470 ARG a1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU a1125 CG CD OE1 OE2 REMARK 470 LYS a1137 CG CD CE NZ REMARK 470 LYS a1167 CG CD CE NZ REMARK 470 LYS a1200 CD CE NZ REMARK 470 ARG a1211 CG CD NE CZ NH1 NH2 REMARK 470 LYS b1019 CG CD CE NZ REMARK 470 SER b1058 OG REMARK 470 ARG b1079 CG CD NE CZ NH1 NH2 REMARK 470 GLU b1125 CG CD OE1 OE2 REMARK 470 LYS b1167 CG CD CE NZ REMARK 470 LYS b1189 CG CD CE NZ REMARK 470 LYS b1200 CD CE NZ REMARK 470 LYS c1019 CG CD CE NZ REMARK 470 SER c1058 OG REMARK 470 ARG c1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU c1125 CG CD OE1 OE2 REMARK 470 LYS c1167 CG CD CE NZ REMARK 470 ARG c1178 CG CD NE CZ NH1 NH2 REMARK 470 LYS c1200 CD CE NZ REMARK 470 ARG c1211 CG CD NE CZ NH1 NH2 REMARK 470 LYS d1019 CG CD CE NZ REMARK 470 SER d1058 OG REMARK 470 ARG d1096 CG CD NE CZ NH1 NH2 REMARK 470 ASP d1098 CG OD1 OD2 REMARK 470 GLU d1125 CG CD OE1 OE2 REMARK 470 LYS d1167 CG CD CE NZ REMARK 470 ARG d1178 CG CD NE CZ NH1 NH2 REMARK 470 LYS d1200 CD CE NZ REMARK 470 ARG d1211 CG CD NE CZ NH1 NH2 REMARK 470 LYS e1019 CG CD CE NZ REMARK 470 SER e1058 OG REMARK 470 ARG e1079 CG CD NE CZ NH1 NH2 REMARK 470 ARG e1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU e1125 CG CD OE1 OE2 REMARK 470 LYS e1167 CG CD CE NZ REMARK 470 ARG e1178 CG CD NE CZ NH1 NH2 REMARK 470 LYS e1200 CD CE NZ REMARK 470 ARG e1211 CG CD NE CZ NH1 NH2 REMARK 470 SER W1058 OG REMARK 470 ARG W1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU W1125 CG CD OE1 OE2 REMARK 470 LYS W1167 CG CD CE NZ REMARK 470 LYS W1200 CD CE NZ REMARK 470 ARG W1211 CG CD NE CZ NH1 NH2 REMARK 470 LYS X1019 CG CD CE NZ REMARK 470 SER X1058 OG REMARK 470 ARG X1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU X1125 CG CD OE1 OE2 REMARK 470 LYS X1167 CG CD CE NZ REMARK 470 ARG X1191 CG CD NE CZ NH1 NH2 REMARK 470 LYS X1200 CD CE NZ REMARK 470 ARG X1211 CG CD NE CZ NH1 NH2 REMARK 470 GLU X1213 CG CD OE1 OE2 REMARK 470 LYS Y1019 CG CD CE NZ REMARK 470 SER Y1058 OG REMARK 470 ARG Y1096 CG CD NE CZ NH1 NH2 REMARK 470 GLU Y1125 CG CD OE1 OE2 REMARK 470 LYS Y1167 CG CD CE NZ REMARK 470 LYS Y1200 CD CE NZ REMARK 470 ARG Y1211 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 CB ARGZZ 1211 OE2 GLUZZ 1213 1.97 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS REMARK 500 REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500 REMARK 500 DISTANCE CUTOFF: REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 O GLYEE 248 O GLYWW 1132 2654 1.83 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASNZZ1028 100.54 -59.89 REMARK 500 ASPZZ1053 -47.56 83.00 REMARK 500 METZZ1054 12.22 -152.55 REMARK 500 ASNZZ1068 109.68 -173.52 REMARK 500 TYRZZ1069 -68.47 -131.78 REMARK 500 ARGZZ1079 74.32 -115.39 REMARK 500 SERZZ1095 136.00 -38.54 REMARK 500 VALZZ1188 11.64 -141.43 REMARK 500 SERZZ1201 30.83 72.60 REMARK 500 LEUAA 27 -150.98 -119.15 REMARK 500 ASPAA 49 70.99 60.16 REMARK 500 SERAA 69 54.45 -114.44 REMARK 500 ASPAA 93 -131.20 -96.67 REMARK 500 LEUAA 94 -150.64 -127.12 REMARK 500 VALAA 180 -50.36 -122.84 REMARK 500 METAA 181 115.36 -175.86 REMARK 500 ALAAA 194 -52.36 -127.46 REMARK 500 ARGAA 206 -144.47 -117.68 REMARK 500 LEUBB 27 -150.46 -119.01 REMARK 500 GLUBB 46 79.56 -105.41 REMARK 500 SERBB 69 53.89 -113.85 REMARK 500 VALBB 180 -51.10 -123.05 REMARK 500 METBB 181 115.40 -175.17 REMARK 500 ALABB 194 -51.50 -127.61 REMARK 500 ARGBB 206 -146.23 -116.26 REMARK 500 LEUCC 27 -150.59 -118.47 REMARK 500 ASPCC 49 69.68 60.56 REMARK 500 SERCC 69 52.61 -111.44 REMARK 500 METCC 181 115.16 -176.46 REMARK 500 ALACC 194 -50.39 -127.16 REMARK 500 ARGCC 206 -145.36 -118.36 REMARK 500 ARGCC 206 -146.01 -117.67 REMARK 500 LEUDD 27 -149.38 -117.84 REMARK 500 ASPDD 49 69.67 61.28 REMARK 500 SERDD 69 53.46 -114.46 REMARK 500 VALDD 180 -50.31 -120.91 REMARK 500 METDD 181 114.07 -176.68 REMARK 500 ALADD 194 -51.77 -126.74 REMARK 500 ARGDD 206 -147.39 -119.62 REMARK 500 LEUEE 27 -150.19 -119.43 REMARK 500 ASPEE 49 68.88 60.97 REMARK 500 SEREE 69 54.53 -115.51 REMARK 500 METEE 181 115.10 -176.54 REMARK 500 ALAEE 194 -51.51 -127.27 REMARK 500 ARGEE 206 -145.82 -116.73 REMARK 500 ARGEE 206 -144.60 -118.23 REMARK 500 LEUFF 27 -148.04 -117.76 REMARK 500 ASPFF 49 69.49 60.43 REMARK 500 SERFF 69 52.99 -113.89 REMARK 500 VALFF 180 -50.57 -122.68 REMARK 500 REMARK 500 THIS ENTRY HAS 158 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL DBREF 7PAAZZ 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAAA 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAABB 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAACC 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAADD 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAEE 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAFF 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAGG 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAHH 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAII 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAJJ 22 289 UNP P03089 VP1_POVJC 23 290 DBREF 7PAAKK 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAaa 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAbb 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAcc 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAdd 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAee 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAWW 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAXX 1003 1248 PDB 7PAA 7PAA 1003 1248 DBREF 7PAAYY 1003 1248 PDB 7PAA 7PAA 1003 1248 SEQADV 7PAA GLYAA 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERAA 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISAA 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METAA 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYBB 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERBB 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISBB 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METBB 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYCC 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERCC 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISCC 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METCC 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYDD 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERDD 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISDD 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METDD 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYEE 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SEREE 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISEE 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METEE 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYFF 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERFF 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISFF 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METFF 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYGG 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERGG 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISGG 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METGG 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYHH 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERHH 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISHH 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METHH 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYII 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERII 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISII 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METII 21 UNP P03089 EXPRESSION TAG SEQADV 7PAA GLYJJ 18 UNP P03089 EXPRESSION TAG SEQADV 7PAA SERJJ 19 UNP P03089 EXPRESSION TAG SEQADV 7PAA HISJJ 20 UNP P03089 EXPRESSION TAG SEQADV 7PAA METJJ 21 UNP P03089 EXPRESSION TAG SEQRES 1ZZ 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2ZZ 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3ZZ 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4ZZ 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5ZZ 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6ZZ 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7ZZ 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8ZZ 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9ZZ 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10ZZ 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11ZZ 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12ZZ 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13ZZ 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14ZZ 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15ZZ 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16ZZ 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17ZZ 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18ZZ 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19ZZ 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20ZZ 252 VAL THR VAL SER SER SEQRES 1AA 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2AA 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3AA 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4AA 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5AA 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6AA 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7AA 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8AA 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9AA 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10AA 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11AA 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12AA 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13AA 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14AA 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15AA 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16AA 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17AA 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18AA 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19AA 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20AA 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21AA 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1BB 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2BB 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3BB 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4BB 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5BB 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6BB 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7BB 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8BB 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9BB 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10BB 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11BB 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12BB 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13BB 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14BB 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15BB 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16BB 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17BB 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18BB 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19BB 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20BB 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21BB 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1CC 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2CC 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3CC 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4CC 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5CC 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6CC 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7CC 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8CC 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9CC 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10CC 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11CC 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12CC 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13CC 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14CC 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15CC 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16CC 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17CC 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18CC 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19CC 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20CC 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21CC 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1DD 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2DD 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3DD 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4DD 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5DD 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6DD 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7DD 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8DD 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9DD 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10DD 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11DD 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12DD 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13DD 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14DD 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15DD 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16DD 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17DD 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18DD 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19DD 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20DD 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21DD 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1EE 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2EE 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3EE 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4EE 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5EE 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6EE 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7EE 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8EE 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9EE 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10EE 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11EE 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12EE 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13EE 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14EE 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15EE 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16EE 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17EE 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18EE 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19EE 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20EE 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21EE 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1FF 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2FF 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3FF 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4FF 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5FF 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6FF 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7FF 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8FF 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9FF 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10FF 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11FF 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12FF 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13FF 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14FF 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15FF 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16FF 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17FF 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18FF 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19FF 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20FF 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21FF 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1GG 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2GG 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3GG 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4GG 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5GG 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6GG 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7GG 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8GG 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9GG 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10GG 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11GG 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12GG 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13GG 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14GG 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15GG 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16GG 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17GG 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18GG 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19GG 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20GG 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21GG 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1HH 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2HH 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3HH 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4HH 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5HH 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6HH 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7HH 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8HH 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9HH 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10HH 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11HH 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12HH 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13HH 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14HH 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15HH 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16HH 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17HH 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18HH 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19HH 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20HH 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21HH 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1II 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2II 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3II 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4II 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5II 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6II 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7II 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8II 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9II 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10II 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11II 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12II 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13II 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14II 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15II 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16II 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17II 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18II 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19II 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20II 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21II 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1JJ 272 GLY SER HIS MET GLY GLY VAL GLU VAL LEU GLU VAL LYS SEQRES 2JJ 272 THR GLY VAL ASP SER ILE THR GLU VAL GLU CYS PHE LEU SEQRES 3JJ 272 THR PRO GLU MET GLY ASP PRO ASP GLU HIS LEU ARG GLY SEQRES 4JJ 272 PHE SER LYS SER ILE SER ILE SER ASP THR PHE GLU SER SEQRES 5JJ 272 ASP SER PRO ASN ARG ASP MET LEU PRO CYS TYR SER VAL SEQRES 6JJ 272 ALA ARG ILE PRO LEU PRO ASN LEU ASN GLU ASP LEU THR SEQRES 7JJ 272 CYS GLY ASN ILE LEU MET TRP GLU ALA VAL THR LEU LYS SEQRES 8JJ 272 THR GLU VAL ILE GLY VAL THR SER LEU MET ASN VAL HIS SEQRES 9JJ 272 SER ASN GLY GLN ALA THR HIS ASP ASN GLY ALA GLY LYS SEQRES 10JJ 272 PRO VAL GLN GLY THR SER PHE HIS PHE PHE SER VAL GLY SEQRES 11JJ 272 GLY GLU ALA LEU GLU LEU GLN GLY VAL LEU PHE ASN TYR SEQRES 12JJ 272 ARG THR LYS TYR PRO ASP GLY THR ILE PHE PRO LYS ASN SEQRES 13JJ 272 ALA THR VAL GLN SER GLN VAL MET ASN THR GLU HIS LYS SEQRES 14JJ 272 ALA TYR LEU ASP LYS ASN LYS ALA TYR PRO VAL GLU CYS SEQRES 15JJ 272 TRP VAL PRO ASP PRO THR ARG ASN GLU ASN THR ARG TYR SEQRES 16JJ 272 PHE GLY THR LEU THR GLY GLY GLU ASN VAL PRO PRO VAL SEQRES 17JJ 272 LEU HIS ILE THR ASN THR ALA THR THR VAL LEU LEU ASP SEQRES 18JJ 272 GLU PHE GLY VAL GLY PRO LEU CYS LYS GLY ASP ASN LEU SEQRES 19JJ 272 TYR LEU SER ALA VAL ASP VAL CYS GLY MET PHE THR ASN SEQRES 20JJ 272 ARG SER GLY SER GLN GLN TRP ARG GLY LEU SER ARG TYR SEQRES 21JJ 272 PHE LYS VAL GLN LEU ARG LYS ARG ARG VAL LYS ASN SEQRES 1KK 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2KK 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3KK 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4KK 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5KK 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6KK 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7KK 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8KK 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9KK 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10KK 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11KK 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12KK 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13KK 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14KK 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15KK 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16KK 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17KK 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18KK 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19KK 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20KK 252 VAL THR VAL SER SER SEQRES 1aa 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2aa 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3aa 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4aa 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5aa 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6aa 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7aa 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8aa 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9aa 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10aa 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11aa 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12aa 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13aa 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14aa 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15aa 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16aa 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17aa 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18aa 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19aa 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20aa 252 VAL THR VAL SER SER SEQRES 1bb 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2bb 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3bb 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4bb 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5bb 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6bb 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7bb 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8bb 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9bb 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10bb 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11bb 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12bb 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13bb 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14bb 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15bb 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16bb 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17bb 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18bb 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19bb 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20bb 252 VAL THR VAL SER SER SEQRES 1cc 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2cc 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3cc 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4cc 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5cc 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6cc 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7cc 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8cc 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9cc 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10cc 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11cc 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12cc 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13cc 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14cc 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15cc 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16cc 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17cc 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18cc 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19cc 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20cc 252 VAL THR VAL SER SER SEQRES 1dd 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2dd 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3dd 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4dd 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5dd 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6dd 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7dd 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8dd 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9dd 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10dd 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11dd 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12dd 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13dd 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14dd 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15dd 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16dd 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17dd 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18dd 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19dd 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20dd 252 VAL THR VAL SER SER SEQRES 1ee 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2ee 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3ee 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4ee 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5ee 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6ee 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7ee 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8ee 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9ee 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10ee 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11ee 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12ee 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13ee 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14ee 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15ee 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16ee 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17ee 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18ee 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19ee 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20ee 252 VAL THR VAL SER SER SEQRES 1WW 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2WW 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3WW 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4WW 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5WW 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6WW 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7WW 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8WW 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9WW 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10WW 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11WW 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12WW 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13WW 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14WW 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15WW 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16WW 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17WW 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18WW 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19WW 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20WW 252 VAL THR VAL SER SER SEQRES 1XX 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2XX 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3XX 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4XX 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5XX 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6XX 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7XX 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8XX 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9XX 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10XX 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11XX 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12XX 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13XX 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14XX 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15XX 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16XX 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17XX 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18XX 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19XX 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20XX 252 VAL THR VAL SER SER SEQRES 1YY 252 GLY SER TYR VAL LEU THR GLN PRO PRO SER VAL SER VAL SEQRES 2YY 252 ALA PRO GLY LYS THR ALA ARG ILE THR CYS GLY GLY ASN SEQRES 3YY 252 ASN ILE GLY SER ARG SER VAL HIS TRP TYR GLN HIS LYS SEQRES 4YY 252 PRO GLY GLN ALA PRO VAL MET ILE ILE SER TYR ASP MET SEQRES 5YY 252 ASN ARG PRO SER GLY ILE PRO GLU ARG VAL SER GLY SER SEQRES 6YY 252 ASN TYR GLY ASN THR ALA THR LEU THR ILE SER ARG VAL SEQRES 7YY 252 GLU ALA GLY ASP GLU ALA ASP TYR TYR CYS GLN VAL TRP SEQRES 8YY 252 ASP SER ARG SER ASP HIS PRO TYR VAL PHE GLY THR GLY SEQRES 9YY 252 THR ARG VAL THR VAL LEU GLY SER THR SER GLY SER GLY SEQRES 10YY 252 LYS PRO GLY SER GLY GLU GLY SER THR LYS GLY GLU VAL SEQRES 11YY 252 GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS PRO GLY SEQRES 12YY 252 GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY ILE THR SEQRES 13YY 252 PHE GLN TYR TYR ALA MET ASN TRP VAL ARG GLN ALA PRO SEQRES 14YY 252 GLY LYS GLY LEU GLU TRP VAL SER SER ILE GLY GLY ARG SEQRES 15YY 252 GLY ASP THR THR TYR TYR THR ASP SER VAL LYS GLY ARG SEQRES 16YY 252 PHE THR ILE SER ARG ASP ASN SER LYS SER THR LEU TYR SEQRES 17YY 252 LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR ALA VAL SEQRES 18YY 252 TYR TYR CYS ALA LYS GLU PRO PHE ASP SER SER GLY ASP SEQRES 19YY 252 HIS ARG GLY VAL PHE ASP TYR TRP GLY GLN GLY THR LEU SEQRES 20YY 252 VAL THR VAL SER SER FORMUL 21 HOH *23(H2 O) HELIX 1 AA1 ASNZZ 1029 ARGZZ 1033 5 5 HELIX 2 AA2 GLUZZ 1081 GLUZZ 1085 5 5 HELIX 3 AA3 THRZZ 1152 TYRZZ 1156 5 5 HELIX 4 AA4 ASPZZ 1186 LYSZZ 1189 5 4 HELIX 5 AA5 ARGZZ 1211 THRZZ 1215 5 5 HELIX 6 AA6 GLYAA 32 ASPAA 34 5 3 HELIX 7 AA7 ASPAA 51 ARGAA 55 5 5 HELIX 8 AA8 ASNAA 73 LEUAA 77 5 5 HELIX 9 AA9 GLYAA 113 ASNAA 119 5 7 HELIX 10 AB1 THRAA 175 VALAA 180 5 6 HELIX 11 AB2 GLYBB 32 ASPBB 34 5 3 HELIX 12 AB3 ASPBB 51 ARGBB 55 5 5 HELIX 13 AB4 ASNBB 73 LEUBB 77 5 5 HELIX 14 AB5 GLYBB 113 ASNBB 119 5 7 HELIX 15 AB6 THRBB 175 VALBB 180 5 6 HELIX 16 AB7 GLYCC 32 ASPCC 34 5 3 HELIX 17 AB8 ASPCC 51 ARGCC 55 5 5 HELIX 18 AB9 ASNCC 73 LEUCC 77 5 5 HELIX 19 AC1 GLYCC 113 ASNCC 119 5 7 HELIX 20 AC2 THRCC 175 VALCC 180 5 6 HELIX 21 AC3 GLYDD 32 ASPDD 34 5 3 HELIX 22 AC4 ASPDD 51 ARGDD 55 5 5 HELIX 23 AC5 ASNDD 73 LEUDD 77 5 5 HELIX 24 AC6 GLYDD 113 ASNDD 119 5 7 HELIX 25 AC7 THRDD 175 VALDD 180 5 6 HELIX 26 AC8 GLYEE 32 ASPEE 34 5 3 HELIX 27 AC9 ASPEE 51 ARGEE 55 5 5 HELIX 28 AD1 ASNEE 73 LEUEE 77 5 5 HELIX 29 AD2 GLYEE 113 ASNEE 119 5 7 HELIX 30 AD3 THREE 175 VALEE 180 5 6 HELIX 31 AD4 GLYFF 32 ASPFF 34 5 3 HELIX 32 AD5 ASPFF 51 ARGFF 55 5 5 HELIX 33 AD6 ASNFF 73 LEUFF 77 5 5 HELIX 34 AD7 GLYFF 113 ASNFF 119 5 7 HELIX 35 AD8 THRFF 175 VALFF 180 5 6 HELIX 36 AD9 PROFF 196 GLUFF 198 5 3 HELIX 37 AE1 GLYGG 32 ASPGG 34 5 3 HELIX 38 AE2 ASPGG 51 ARGGG 55 5 5 HELIX 39 AE3 ASNGG 73 LEUGG 77 5 5 HELIX 40 AE4 GLYGG 113 ASNGG 119 5 7 HELIX 41 AE5 THRGG 175 VALGG 180 5 6 HELIX 42 AE6 GLYHH 32 ASPHH 34 5 3 HELIX 43 AE7 ASPHH 51 ARGHH 55 5 5 HELIX 44 AE8 ASNHH 73 LEUHH 77 5 5 HELIX 45 AE9 GLYHH 113 ASNHH 119 5 7 HELIX 46 AF1 THRHH 175 VALHH 180 5 6 HELIX 47 AF2 GLYII 32 ASPII 34 5 3 HELIX 48 AF3 ASPII 51 ARGII 55 5 5 HELIX 49 AF4 ASNII 73 LEUII 77 5 5 HELIX 50 AF5 GLYII 113 ASNII 119 5 7 HELIX 51 AF6 THRII 175 VALII 180 5 6 HELIX 52 AF7 GLYJJ 32 ASPJJ 34 5 3 HELIX 53 AF8 ASPJJ 51 ARGJJ 55 5 5 HELIX 54 AF9 ASNJJ 73 LEUJJ 77 5 5 HELIX 55 AG1 GLYJJ 113 ASNJJ 119 5 7 HELIX 56 AG2 THRJJ 175 VALJJ 180 5 6 HELIX 57 AG3 ASNKK 1029 ARGKK 1033 5 5 HELIX 58 AG4 GLUKK 1081 GLUKK 1085 5 5 HELIX 59 AG5 THRKK 1152 TYRKK 1156 5 5 HELIX 60 AG6 ASPKK 1186 LYSKK 1189 5 4 HELIX 61 AG7 ARGKK 1211 THRKK 1215 5 5 HELIX 62 AG8 ASNaa 1029 ARGaa 1033 5 5 HELIX 63 AG9 GLUaa 1081 GLUaa 1085 5 5 HELIX 64 AH1 THRaa 1152 TYRaa 1156 5 5 HELIX 65 AH2 ASPaa 1186 LYSaa 1189 5 4 HELIX 66 AH3 ARGaa 1211 THRaa 1215 5 5 HELIX 67 AH4 ASNbb 1029 ARGbb 1033 5 5 HELIX 68 AH5 GLUbb 1081 GLUbb 1085 5 5 HELIX 69 AH6 THRbb 1152 TYRbb 1156 5 5 HELIX 70 AH7 ASPbb 1186 LYSbb 1189 5 4 HELIX 71 AH8 ARGbb 1211 THRbb 1215 5 5 HELIX 72 AH9 ASNcc 1029 ARGcc 1033 5 5 HELIX 73 AI1 GLUcc 1081 GLUcc 1085 5 5 HELIX 74 AI2 THRcc 1152 TYRcc 1156 5 5 HELIX 75 AI3 ASPcc 1186 LYScc 1189 5 4 HELIX 76 AI4 ARGcc 1211 THRcc 1215 5 5 HELIX 77 AI5 ASNdd 1029 ARGdd 1033 5 5 HELIX 78 AI6 GLUdd 1081 GLUdd 1085 5 5 HELIX 79 AI7 THRdd 1152 TYRdd 1156 5 5 HELIX 80 AI8 ASPdd 1186 LYSdd 1189 5 4 HELIX 81 AI9 ARGdd 1211 THRdd 1215 5 5 HELIX 82 AJ1 ASNee 1029 ARGee 1033 5 5 HELIX 83 AJ2 GLUee 1081 GLUee 1085 5 5 HELIX 84 AJ3 THRee 1152 TYRee 1156 5 5 HELIX 85 AJ4 ASPee 1186 LYSee 1189 5 4 HELIX 86 AJ5 ARGee 1211 THRee 1215 5 5 HELIX 87 AJ6 ASNWW 1029 ARGWW 1033 5 5 HELIX 88 AJ7 GLUWW 1081 GLUWW 1085 5 5 HELIX 89 AJ8 THRWW 1152 TYRWW 1156 5 5 HELIX 90 AJ9 ASPWW 1186 LYSWW 1189 5 4 HELIX 91 AK1 ARGWW 1211 THRWW 1215 5 5 HELIX 92 AK2 ASNXX 1029 ARGXX 1033 5 5 HELIX 93 AK3 GLUXX 1081 GLUXX 1085 5 5 HELIX 94 AK4 THRXX 1152 TYRXX 1156 5 5 HELIX 95 AK5 ASPXX 1186 LYSXX 1189 5 4 HELIX 96 AK6 ARGXX 1211 THRXX 1215 5 5 HELIX 97 AK7 ASNYY 1029 ARGYY 1033 5 5 HELIX 98 AK8 GLUYY 1081 GLUYY 1085 5 5 HELIX 99 AK9 THRYY 1152 TYRYY 1156 5 5 HELIX 100 AL1 ASPYY 1186 LYSYY 1189 5 4 HELIX 101 AL2 ARGYY 1211 THRYY 1215 5 5 SHEET 1 AA1 4 LEUZZ1007 THRZZ1008 0 SHEET 2 AA1 4 ALAZZ1021 GLYZZ1027 -1 O GLYZZ1026 N THRZZ1008 SHEET 3 AA1 4 THRZZ1072 ILEZZ1077 -1 O ILEZZ1077 N ALAZZ1021 SHEET 4 AA1 4 VALZZ1064 ASNZZ1068 -1 N SERZZ1065 O THRZZ1076 SHEET 1 AA2 5 SERZZ1012 SERZZ1014 0 SHEET 2 AA2 5 THRZZ1107 THRZZ1110 1 O ARGZZ1108 N VALZZ1013 SHEET 3 AA2 5 ALAZZ1086 TRPZZ1093 -1 N TYRZZ1088 O THRZZ1107 SHEET 4 AA2 5 HISZZ1036 HISZZ1040 -1 N TYRZZ1038 O TYRZZ1089 SHEET 5 AA2 5 VALZZ1047 ILEZZ1050 -1 O ILEZZ1050 N TRPZZ1037 SHEET 1 AA3 4 SERZZ1012 SERZZ1014 0 SHEET 2 AA3 4 THRZZ1107 THRZZ1110 1 O ARGZZ1108 N VALZZ1013 SHEET 3 AA3 4 ALAZZ1086 TRPZZ1093 -1 N TYRZZ1088 O THRZZ1107 SHEET 4 AA3 4 TYRZZ1101 PHEZZ1103 -1 O VALZZ1102 N VALZZ1092 SHEET 1 AA4 4 GLNZZ1127 SERZZ1131 0 SHEET 2 AA4 4 LEUZZ1142 SERZZ1149 -1 O ALAZZ1147 N VALZZ1129 SHEET 3 AA4 4 THRZZ1202 METZZ1207 -1 O METZZ1207 N LEUZZ1142 SHEET 4 AA4 4 PHEZZ1192 ASPZZ1197 -1 N THRZZ1193 O GLNZZ1206 SHEET 1 AA5 6 GLYZZ1134 LEUZZ1135 0 SHEET 2 AA5 6 THRZZ1242 THRZZ1245 1 O THRZZ1245 N GLYZZ1134 SHEET 3 AA5 6 ALAZZ1216 LYSZZ1222 -1 N TYRZZ1218 O THRZZ1242 SHEET 4 AA5 6 METZZ1158 GLNZZ1163 -1 N VALZZ1161 O TYRZZ1219 SHEET 5 AA5 6 LEUZZ1169 ILEZZ1175 -1 O GLUZZ1170 N ARGZZ1162 SHEET 6 AA5 6 THRZZ1182 TYRZZ1184 -1 O TYRZZ1183 N SERZZ1174 SHEET 1 AA6 4 GLYZZ1134 LEUZZ1135 0 SHEET 2 AA6 4 THRZZ1242 THRZZ1245 1 O THRZZ1245 N GLYZZ1134 SHEET 3 AA6 4 ALAZZ1216 LYSZZ1222 -1 N TYRZZ1218 O THRZZ1242 SHEET 4 AA6 4 TYRZZ1237 TRPZZ1238 -1 O TYRZZ1237 N LYSZZ1222 SHEET 1 AA7 4 GLUAA 25 VALAA 29 0 SHEET 2 AA7 4 SERAA 275 LYSAA 288 -1 O ARGAA 286 N LEUAA 27 SHEET 3 AA7 4 LEUAA 100 ILEAA 112 -1 N GLUAA 103 O ARGAA 283 SHEET 4 AA7 4 THRAA 234 VALAA 235 -1 O THRAA 234 N LEUAA 107 SHEET 1 AA8 4 ILEAA 36 LEUAA 43 0 SHEET 2 AA8 4 SERAA 275 LYSAA 288 -1 O PHEAA 278 N CYSAA 41 SHEET 3 AA8 4 LEUAA 100 ILEAA 112 -1 N GLUAA 103 O ARGAA 283 SHEET 4 AA8 4 LEUAA 245 CYSAA 246 -1 O CYSAA 246 N TRPAA 102 SHEET 1 AA9 3 SERAA 81 PROAA 86 0 SHEET 2 AA9 3 ASNAA 250 THRAA 263 -1 O LEUAA 253 N ALAAA 83 SHEET 3 AA9 3 GLNAA 269 GLYAA 273 -1 O GLNAA 270 N PHEAA 262 SHEET 1 AB1 5 SERAA 81 PROAA 86 0 SHEET 2 AB1 5 ASNAA 250 THRAA 263 -1 O LEUAA 253 N ALAAA 83 SHEET 3 AB1 5 SERAA 140 GLYAA 147 -1 N PHEAA 143 O VALAA 256 SHEET 4 AB1 5 THRAA 210 THRAA 217 -1 O ARGAA 211 N VALAA 146 SHEET 5 AB1 5 VALEE 225 THREE 229 -1 O ILEEE 228 N GLYAA 214 SHEET 1 AB2 3 LYSAA 186 TYRAA 188 0 SHEET 2 AB2 3 GLUAA 152 GLYAA 155 -1 N LEUAA 153 O ALAAA 187 SHEET 3 AB2 3 TRPAA 200 PROAA 202 -1 O VALAA 201 N GLNAA 154 SHEET 1 AB3 5 VALAA 225 THRAA 229 0 SHEET 2 AB3 5 THRBB 210 THRBB 217 -1 O GLYBB 214 N ILEAA 228 SHEET 3 AB3 5 SERBB 140 GLYBB 147 -1 N VALBB 146 O ARGBB 211 SHEET 4 AB3 5 ASNBB 250 THRBB 263 -1 O TYRBB 252 N GLYBB 147 SHEET 5 AB3 5 SERBB 81 PROBB 86 -1 N ALABB 83 O LEUBB 253 SHEET 1 AB4 5 VALAA 225 THRAA 229 0 SHEET 2 AB4 5 THRBB 210 THRBB 217 -1 O GLYBB 214 N ILEAA 228 SHEET 3 AB4 5 SERBB 140 GLYBB 147 -1 N VALBB 146 O ARGBB 211 SHEET 4 AB4 5 ASNBB 250 THRBB 263 -1 O TYRBB 252 N GLYBB 147 SHEET 5 AB4 5 GLNBB 269 GLYBB 273 -1 O GLNBB 270 N PHEBB 262 SHEET 1 AB5 4 GLUBB 25 VALBB 29 0 SHEET 2 AB5 4 SERBB 275 LYSBB 288 -1 O ARGBB 286 N LEUBB 27 SHEET 3 AB5 4 LEUBB 100 ILEBB 112 -1 N GLUBB 103 O ARGBB 283 SHEET 4 AB5 4 THRBB 234 VALBB 235 -1 O THRBB 234 N LEUBB 107 SHEET 1 AB6 4 ILEBB 36 LEUBB 43 0 SHEET 2 AB6 4 SERBB 275 LYSBB 288 -1 O VALBB 280 N VALBB 39 SHEET 3 AB6 4 LEUBB 100 ILEBB 112 -1 N GLUBB 103 O ARGBB 283 SHEET 4 AB6 4 LEUBB 245 CYSBB 246 -1 O CYSBB 246 N TRPBB 102 SHEET 1 AB7 3 LYSBB 186 TYRBB 188 0 SHEET 2 AB7 3 GLUBB 152 GLYBB 155 -1 N LEUBB 153 O ALABB 187 SHEET 3 AB7 3 TRPBB 200 PROBB 202 -1 O VALBB 201 N GLNBB 154 SHEET 1 AB8 5 VALBB 225 THRBB 229 0 SHEET 2 AB8 5 THRCC 210 THRCC 217 -1 O GLYCC 214 N ILEBB 228 SHEET 3 AB8 5 SERCC 140 GLYCC 147 -1 N VALCC 146 O ARGCC 211 SHEET 4 AB8 5 ASNCC 250 THRCC 263 -1 O TYRCC 252 N GLYCC 147 SHEET 5 AB8 5 SERCC 81 PROCC 86 -1 N ALACC 83 O LEUCC 253 SHEET 1 AB9 5 VALBB 225 THRBB 229 0 SHEET 2 AB9 5 THRCC 210 THRCC 217 -1 O GLYCC 214 N ILEBB 228 SHEET 3 AB9 5 SERCC 140 GLYCC 147 -1 N VALCC 146 O ARGCC 211 SHEET 4 AB9 5 ASNCC 250 THRCC 263 -1 O TYRCC 252 N GLYCC 147 SHEET 5 AB9 5 GLNCC 269 GLYCC 273 -1 O GLNCC 270 N PHECC 262 SHEET 1 AC1 4 VALCC 26 VALCC 29 0 SHEET 2 AC1 4 SERCC 275 VALCC 287 -1 O ARGCC 286 N LEUCC 27 SHEET 3 AC1 4 ILECC 99 ILECC 112 -1 N GLUCC 103 O ARGCC 283 SHEET 4 AC1 4 THRCC 234 VALCC 235 -1 O THRCC 234 N LEUCC 107 SHEET 1 AC2 4 ILECC 36 LEUCC 43 0 SHEET 2 AC2 4 SERCC 275 VALCC 287 -1 O VALCC 280 N VALCC 39 SHEET 3 AC2 4 ILECC 99 ILECC 112 -1 N GLUCC 103 O ARGCC 283 SHEET 4 AC2 4 LEUCC 245 CYSCC 246 -1 O CYSCC 246 N TRPCC 102 SHEET 1 AC3 3 LYSCC 186 LEUCC 189 0 SHEET 2 AC3 3 LEUCC 151 GLYCC 155 -1 N LEUCC 153 O ALACC 187 SHEET 3 AC3 3 TRPCC 200 PROCC 202 -1 O VALCC 201 N GLNCC 154 SHEET 1 AC4 5 VALCC 225 THRCC 229 0 SHEET 2 AC4 5 THRDD 210 THRDD 217 -1 O GLYDD 214 N ILECC 228 SHEET 3 AC4 5 SERDD 140 GLYDD 147 -1 N VALDD 146 O ARGDD 211 SHEET 4 AC4 5 ASNDD 250 THRDD 263 -1 O VALDD 256 N PHEDD 143 SHEET 5 AC4 5 SERDD 81 PRODD 86 -1 N ALADD 83 O LEUDD 253 SHEET 1 AC5 5 VALCC 225 THRCC 229 0 SHEET 2 AC5 5 THRDD 210 THRDD 217 -1 O GLYDD 214 N ILECC 228 SHEET 3 AC5 5 SERDD 140 GLYDD 147 -1 N VALDD 146 O ARGDD 211 SHEET 4 AC5 5 ASNDD 250 THRDD 263 -1 O VALDD 256 N PHEDD 143 SHEET 5 AC5 5 GLNDD 269 GLYDD 273 -1 O GLNDD 270 N PHEDD 262 SHEET 1 AC6 4 GLUDD 25 VALDD 29 0 SHEET 2 AC6 4 SERDD 275 LYSDD 288 -1 O ARGDD 286 N LEUDD 27 SHEET 3 AC6 4 LEUDD 100 ILEDD 112 -1 N VALDD 105 O GLNDD 281 SHEET 4 AC6 4 THRDD 234 VALDD 235 -1 O THRDD 234 N LEUDD 107 SHEET 1 AC7 4 ILEDD 36 LEUDD 43 0 SHEET 2 AC7 4 SERDD 275 LYSDD 288 -1 O PHEDD 278 N CYSDD 41 SHEET 3 AC7 4 LEUDD 100 ILEDD 112 -1 N VALDD 105 O GLNDD 281 SHEET 4 AC7 4 LEUDD 245 CYSDD 246 -1 O CYSDD 246 N TRPDD 102 SHEET 1 AC8 3 LYSDD 186 TYRDD 188 0 SHEET 2 AC8 3 GLUDD 152 GLYDD 155 -1 N LEUDD 153 O ALADD 187 SHEET 3 AC8 3 TRPDD 200 PRODD 202 -1 O VALDD 201 N GLNDD 154 SHEET 1 AC9 5 VALDD 225 THRDD 229 0 SHEET 2 AC9 5 THREE 210 THREE 217 -1 O GLYEE 214 N ILEDD 228 SHEET 3 AC9 5 SEREE 140 GLYEE 147 -1 N VALEE 146 O ARGEE 211 SHEET 4 AC9 5 ASNEE 250 THREE 263 -1 O TYREE 252 N GLYEE 147 SHEET 5 AC9 5 SEREE 81 PROEE 86 -1 N ALAEE 83 O LEUEE 253 SHEET 1 AD1 5 VALDD 225 THRDD 229 0 SHEET 2 AD1 5 THREE 210 THREE 217 -1 O GLYEE 214 N ILEDD 228 SHEET 3 AD1 5 SEREE 140 GLYEE 147 -1 N VALEE 146 O ARGEE 211 SHEET 4 AD1 5 ASNEE 250 THREE 263 -1 O TYREE 252 N GLYEE 147 SHEET 5 AD1 5 GLNEE 269 GLYEE 273 -1 O GLNEE 270 N PHEEE 262 SHEET 1 AD2 4 GLUEE 25 VALEE 29 0 SHEET 2 AD2 4 SEREE 275 LYSEE 288 -1 O ARGEE 286 N LEUEE 27 SHEET 3 AD2 4 LEUEE 100 ILEEE 112 -1 N GLUEE 103 O ARGEE 283 SHEET 4 AD2 4 THREE 234 VALEE 235 -1 O THREE 234 N LEUEE 107 SHEET 1 AD3 4 ILEEE 36 LEUEE 43 0 SHEET 2 AD3 4 SEREE 275 LYSEE 288 -1 O PHEEE 278 N CYSEE 41 SHEET 3 AD3 4 LEUEE 100 ILEEE 112 -1 N GLUEE 103 O ARGEE 283 SHEET 4 AD3 4 LEUEE 245 CYSEE 246 -1 O CYSEE 246 N TRPEE 102 SHEET 1 AD4 3 LYSEE 186 TYREE 188 0 SHEET 2 AD4 3 GLUEE 152 GLYEE 155 -1 N LEUEE 153 O ALAEE 187 SHEET 3 AD4 3 TRPEE 200 PROEE 202 -1 O VALEE 201 N GLNEE 154 SHEET 1 AD5 4 GLUFF 25 VALFF 29 0 SHEET 2 AD5 4 SERFF 275 LYSFF 288 -1 O ARGFF 286 N LEUFF 27 SHEET 3 AD5 4 LEUFF 100 ILEFF 112 -1 N GLUFF 103 O ARGFF 283 SHEET 4 AD5 4 THRFF 234 VALFF 235 -1 O THRFF 234 N LEUFF 107 SHEET 1 AD6 4 ILEFF 36 LEUFF 43 0 SHEET 2 AD6 4 SERFF 275 LYSFF 288 -1 O VALFF 280 N VALFF 39 SHEET 3 AD6 4 LEUFF 100 ILEFF 112 -1 N GLUFF 103 O ARGFF 283 SHEET 4 AD6 4 LEUFF 245 CYSFF 246 -1 O CYSFF 246 N TRPFF 102 SHEET 1 AD7 3 SERFF 81 PROFF 86 0 SHEET 2 AD7 3 ASNFF 250 THRFF 263 -1 O LEUFF 253 N ALAFF 83 SHEET 3 AD7 3 GLNFF 269 GLYFF 273 -1 O GLNFF 270 N PHEFF 262 SHEET 1 AD8 5 SERFF 81 PROFF 86 0 SHEET 2 AD8 5 ASNFF 250 THRFF 263 -1 O LEUFF 253 N ALAFF 83 SHEET 3 AD8 5 SERFF 140 GLYFF 147 -1 N GLYFF 147 O TYRFF 252 SHEET 4 AD8 5 THRFF 210 THRFF 217 -1 O ARGFF 211 N VALFF 146 SHEET 5 AD8 5 VALJJ 225 THRJJ 229 -1 O ILEJJ 228 N GLYFF 214 SHEET 1 AD9 3 LYSFF 186 TYRFF 188 0 SHEET 2 AD9 3 GLUFF 152 GLYFF 155 -1 N LEUFF 153 O ALAFF 187 SHEET 3 AD9 3 TRPFF 200 PROFF 202 -1 O VALFF 201 N GLNFF 154 SHEET 1 AE1 5 VALFF 225 THRFF 229 0 SHEET 2 AE1 5 THRGG 210 THRGG 217 -1 O LEUGG 216 N LEUFF 226 SHEET 3 AE1 5 SERGG 140 GLYGG 147 -1 N VALGG 146 O ARGGG 211 SHEET 4 AE1 5 ASNGG 250 THRGG 263 -1 O TYRGG 252 N GLYGG 147 SHEET 5 AE1 5 SERGG 81 PROGG 86 -1 N ALAGG 83 O LEUGG 253 SHEET 1 AE2 5 VALFF 225 THRFF 229 0 SHEET 2 AE2 5 THRGG 210 THRGG 217 -1 O LEUGG 216 N LEUFF 226 SHEET 3 AE2 5 SERGG 140 GLYGG 147 -1 N VALGG 146 O ARGGG 211 SHEET 4 AE2 5 ASNGG 250 THRGG 263 -1 O TYRGG 252 N GLYGG 147 SHEET 5 AE2 5 GLNGG 269 GLYGG 273 -1 O GLNGG 270 N PHEGG 262 SHEET 1 AE3 4 VALGG 26 VALGG 29 0 SHEET 2 AE3 4 SERGG 275 VALGG 287 -1 O ARGGG 286 N LEUGG 27 SHEET 3 AE3 4 LEUGG 100 ILEGG 112 -1 N GLUGG 103 O ARGGG 283 SHEET 4 AE3 4 THRGG 234 VALGG 235 -1 O THRGG 234 N LEUGG 107 SHEET 1 AE4 4 ILEGG 36 LEUGG 43 0 SHEET 2 AE4 4 SERGG 275 VALGG 287 -1 O PHEGG 278 N CYSGG 41 SHEET 3 AE4 4 LEUGG 100 ILEGG 112 -1 N GLUGG 103 O ARGGG 283 SHEET 4 AE4 4 LEUGG 245 CYSGG 246 -1 O CYSGG 246 N TRPGG 102 SHEET 1 AE5 3 LYSGG 186 TYRGG 188 0 SHEET 2 AE5 3 GLUGG 152 GLYGG 155 -1 N LEUGG 153 O ALAGG 187 SHEET 3 AE5 3 TRPGG 200 PROGG 202 -1 O VALGG 201 N GLNGG 154 SHEET 1 AE6 5 VALGG 225 THRGG 229 0 SHEET 2 AE6 5 THRHH 210 THRHH 217 -1 O GLYHH 214 N ILEGG 228 SHEET 3 AE6 5 SERHH 140 GLYHH 147 -1 N VALHH 146 O ARGHH 211 SHEET 4 AE6 5 ASNHH 250 THRHH 263 -1 O VALHH 256 N PHEHH 143 SHEET 5 AE6 5 SERHH 81 PROHH 86 -1 N SERHH 81 O ALAHH 255 SHEET 1 AE7 5 VALGG 225 THRGG 229 0 SHEET 2 AE7 5 THRHH 210 THRHH 217 -1 O GLYHH 214 N ILEGG 228 SHEET 3 AE7 5 SERHH 140 GLYHH 147 -1 N VALHH 146 O ARGHH 211 SHEET 4 AE7 5 ASNHH 250 THRHH 263 -1 O VALHH 256 N PHEHH 143 SHEET 5 AE7 5 GLNHH 269 GLYHH 273 -1 O GLNHH 270 N PHEHH 262 SHEET 1 AE8 4 VALHH 26 VALHH 29 0 SHEET 2 AE8 4 SERHH 275 VALHH 287 -1 O ARGHH 286 N LEUHH 27 SHEET 3 AE8 4 LEUHH 100 ILEHH 112 -1 N VALHH 105 O GLNHH 281 SHEET 4 AE8 4 THRHH 234 VALHH 235 -1 O THRHH 234 N LEUHH 107 SHEET 1 AE9 4 ILEHH 36 LEUHH 43 0 SHEET 2 AE9 4 SERHH 275 VALHH 287 -1 O PHEHH 278 N CYSHH 41 SHEET 3 AE9 4 LEUHH 100 ILEHH 112 -1 N VALHH 105 O GLNHH 281 SHEET 4 AE9 4 LEUHH 245 CYSHH 246 -1 O CYSHH 246 N TRPHH 102 SHEET 1 AF1 3 LYSHH 186 LEUHH 189 0 SHEET 2 AF1 3 LEUHH 151 GLYHH 155 -1 N LEUHH 153 O ALAHH 187 SHEET 3 AF1 3 TRPHH 200 PROHH 202 -1 O VALHH 201 N GLNHH 154 SHEET 1 AF2 5 VALHH 225 THRHH 229 0 SHEET 2 AF2 5 THRII 210 THRII 217 -1 O GLYII 214 N ILEHH 228 SHEET 3 AF2 5 SERII 140 GLYII 147 -1 N VALII 146 O ARGII 211 SHEET 4 AF2 5 ASNII 250 THRII 263 -1 O TYRII 252 N GLYII 147 SHEET 5 AF2 5 SERII 81 PROII 86 -1 N ALAII 83 O LEUII 253 SHEET 1 AF3 5 VALHH 225 THRHH 229 0 SHEET 2 AF3 5 THRII 210 THRII 217 -1 O GLYII 214 N ILEHH 228 SHEET 3 AF3 5 SERII 140 GLYII 147 -1 N VALII 146 O ARGII 211 SHEET 4 AF3 5 ASNII 250 THRII 263 -1 O TYRII 252 N GLYII 147 SHEET 5 AF3 5 GLNII 269 GLYII 273 -1 O GLNII 270 N PHEII 262 SHEET 1 AF4 4 GLUII 25 VALII 29 0 SHEET 2 AF4 4 SERII 275 LYSII 288 -1 O ARGII 286 N LEUII 27 SHEET 3 AF4 4 LEUII 100 ILEII 112 -1 N VALII 105 O GLNII 281 SHEET 4 AF4 4 THRII 234 VALII 235 -1 O THRII 234 N LEUII 107 SHEET 1 AF5 4 ILEII 36 LEUII 43 0 SHEET 2 AF5 4 SERII 275 LYSII 288 -1 O PHEII 278 N CYSII 41 SHEET 3 AF5 4 LEUII 100 ILEII 112 -1 N VALII 105 O GLNII 281 SHEET 4 AF5 4 LEUII 245 CYSII 246 -1 O CYSII 246 N TRPII 102 SHEET 1 AF6 3 LYSII 186 TYRII 188 0 SHEET 2 AF6 3 GLUII 152 GLYII 155 -1 N LEUII 153 O ALAII 187 SHEET 3 AF6 3 TRPII 200 PROII 202 -1 O VALII 201 N GLNII 154 SHEET 1 AF7 5 VALII 225 THRII 229 0 SHEET 2 AF7 5 THRJJ 210 THRJJ 217 -1 O LEUJJ 216 N LEUII 226 SHEET 3 AF7 5 SERJJ 140 GLYJJ 147 -1 N VALJJ 146 O ARGJJ 211 SHEET 4 AF7 5 ASNJJ 250 THRJJ 263 -1 O TYRJJ 252 N GLYJJ 147 SHEET 5 AF7 5 SERJJ 81 PROJJ 86 -1 N ALAJJ 83 O LEUJJ 253 SHEET 1 AF8 5 VALII 225 THRII 229 0 SHEET 2 AF8 5 THRJJ 210 THRJJ 217 -1 O LEUJJ 216 N LEUII 226 SHEET 3 AF8 5 SERJJ 140 GLYJJ 147 -1 N VALJJ 146 O ARGJJ 211 SHEET 4 AF8 5 ASNJJ 250 THRJJ 263 -1 O TYRJJ 252 N GLYJJ 147 SHEET 5 AF8 5 GLNJJ 269 GLYJJ 273 -1 O GLNJJ 270 N PHEJJ 262 SHEET 1 AF9 4 GLUJJ 25 VALJJ 29 0 SHEET 2 AF9 4 SERJJ 275 LYSJJ 288 -1 O ARGJJ 286 N LEUJJ 27 SHEET 3 AF9 4 LEUJJ 100 ILEJJ 112 -1 N VALJJ 105 O GLNJJ 281 SHEET 4 AF9 4 THRJJ 234 VALJJ 235 -1 O THRJJ 234 N LEUJJ 107 SHEET 1 AG1 4 ILEJJ 36 LEUJJ 43 0 SHEET 2 AG1 4 SERJJ 275 LYSJJ 288 -1 O PHEJJ 278 N CYSJJ 41 SHEET 3 AG1 4 LEUJJ 100 ILEJJ 112 -1 N VALJJ 105 O GLNJJ 281 SHEET 4 AG1 4 LEUJJ 245 CYSJJ 246 -1 O CYSJJ 246 N TRPJJ 102 SHEET 1 AG2 3 LYSJJ 186 TYRJJ 188 0 SHEET 2 AG2 3 GLUJJ 152 GLYJJ 155 -1 N LEUJJ 153 O ALAJJ 187 SHEET 3 AG2 3 TRPJJ 200 PROJJ 202 -1 O VALJJ 201 N GLNJJ 154 SHEET 1 AG3 4 LEUKK1007 THRKK1008 0 SHEET 2 AG3 4 ALAKK1021 GLYKK1027 -1 O GLYKK1026 N THRKK1008 SHEET 3 AG3 4 THRKK1072 ILEKK1077 -1 O ILEKK1077 N ALAKK1021 SHEET 4 AG3 4 VALKK1064 ASNKK1068 -1 N SERKK1065 O THRKK1076 SHEET 1 AG4 5 SERKK1012 SERKK1014 0 SHEET 2 AG4 5 THRKK1107 THRKK1110 1 O ARGKK1108 N VALKK1013 SHEET 3 AG4 5 ALAKK1086 TRPKK1093 -1 N TYRKK1088 O THRKK1107 SHEET 4 AG4 5 HISKK1036 HISKK1040 -1 N TYRKK1038 O TYRKK1089 SHEET 5 AG4 5 VALKK1047 ILEKK1050 -1 O ILEKK1050 N TRPKK1037 SHEET 1 AG5 4 SERKK1012 SERKK1014 0 SHEET 2 AG5 4 THRKK1107 THRKK1110 1 O ARGKK1108 N VALKK1013 SHEET 3 AG5 4 ALAKK1086 TRPKK1093 -1 N TYRKK1088 O THRKK1107 SHEET 4 AG5 4 TYRKK1101 PHEKK1103 -1 O VALKK1102 N VALKK1092 SHEET 1 AG6 4 GLNKK1127 SERKK1131 0 SHEET 2 AG6 4 LEUKK1142 SERKK1149 -1 O ALAKK1147 N VALKK1129 SHEET 3 AG6 4 THRKK1202 METKK1207 -1 O METKK1207 N LEUKK1142 SHEET 4 AG6 4 PHEKK1192 ASPKK1197 -1 N THRKK1193 O GLNKK1206 SHEET 1 AG7 6 GLYKK1134 LEUKK1135 0 SHEET 2 AG7 6 THRKK1242 THRKK1245 1 O THRKK1245 N GLYKK1134 SHEET 3 AG7 6 ALAKK1216 LYSKK1222 -1 N TYRKK1218 O THRKK1242 SHEET 4 AG7 6 METKK1158 GLNKK1163 -1 N VALKK1161 O TYRKK1219 SHEET 5 AG7 6 LEUKK1169 ILEKK1175 -1 O GLUKK1170 N ARGKK1162 SHEET 6 AG7 6 THRKK1182 TYRKK1184 -1 O TYRKK1183 N SERKK1174 SHEET 1 AG8 4 GLYKK1134 LEUKK1135 0 SHEET 2 AG8 4 THRKK1242 THRKK1245 1 O THRKK1245 N GLYKK1134 SHEET 3 AG8 4 ALAKK1216 LYSKK1222 -1 N TYRKK1218 O THRKK1242 SHEET 4 AG8 4 TYRKK1237 TRPKK1238 -1 O TYRKK1237 N LYSKK1222 SHEET 1 AG9 4 LEUaa1007 THRaa1008 0 SHEET 2 AG9 4 ALAaa1021 GLYaa1027 -1 O GLYaa1026 N THRaa1008 SHEET 3 AG9 4 THRaa1072 ILEaa1077 -1 O ILEaa1077 N ALAaa1021 SHEET 4 AG9 4 VALaa1064 ASNaa1068 -1 N SERaa1065 O THRaa1076 SHEET 1 AH1 5 SERaa1012 VALaa1015 0 SHEET 2 AH1 5 THRaa1107 VALaa1111 1 O ARGaa1108 N VALaa1013 SHEET 3 AH1 5 ALAaa1086 TRPaa1093 -1 N TYRaa1088 O THRaa1107 SHEET 4 AH1 5 HISaa1036 HISaa1040 -1 N TYRaa1038 O TYRaa1089 SHEET 5 AH1 5 VALaa1047 ILEaa1050 -1 O ILEaa1050 N TRPaa1037 SHEET 1 AH2 4 SERaa1012 VALaa1015 0 SHEET 2 AH2 4 THRaa1107 VALaa1111 1 O ARGaa1108 N VALaa1013 SHEET 3 AH2 4 ALAaa1086 TRPaa1093 -1 N TYRaa1088 O THRaa1107 SHEET 4 AH2 4 TYRaa1101 PHEaa1103 -1 O VALaa1102 N VALaa1092 SHEET 1 AH3 4 GLNaa1127 SERaa1131 0 SHEET 2 AH3 4 LEUaa1142 SERaa1149 -1 O ALAaa1147 N VALaa1129 SHEET 3 AH3 4 THRaa1202 METaa1207 -1 O LEUaa1203 N CYSaa1146 SHEET 4 AH3 4 PHEaa1192 ASPaa1197 -1 N THRaa1193 O GLNaa1206 SHEET 1 AH4 6 GLYaa1134 LEUaa1135 0 SHEET 2 AH4 6 THRaa1242 THRaa1245 1 O THRaa1245 N GLYaa1134 SHEET 3 AH4 6 ALAaa1216 LYSaa1222 -1 N TYRaa1218 O THRaa1242 SHEET 4 AH4 6 METaa1158 GLNaa1163 -1 N VALaa1161 O TYRaa1219 SHEET 5 AH4 6 LEUaa1169 ILEaa1175 -1 O GLUaa1170 N ARGaa1162 SHEET 6 AH4 6 THRaa1182 TYRaa1184 -1 O TYRaa1183 N SERaa1174 SHEET 1 AH5 4 GLYaa1134 LEUaa1135 0 SHEET 2 AH5 4 THRaa1242 THRaa1245 1 O THRaa1245 N GLYaa1134 SHEET 3 AH5 4 ALAaa1216 LYSaa1222 -1 N TYRaa1218 O THRaa1242 SHEET 4 AH5 4 TYRaa1237 TRPaa1238 -1 O TYRaa1237 N LYSaa1222 SHEET 1 AH6 4 LEUbb1007 THRbb1008 0 SHEET 2 AH6 4 ALAbb1021 GLYbb1027 -1 O GLYbb1026 N THRbb1008 SHEET 3 AH6 4 THRbb1072 ILEbb1077 -1 O ILEbb1077 N ALAbb1021 SHEET 4 AH6 4 SERbb1065 ASNbb1068 -1 N SERbb1065 O THRbb1076 SHEET 1 AH7 5 SERbb1012 SERbb1014 0 SHEET 2 AH7 5 THRbb1107 THRbb1110 1 O ARGbb1108 N VALbb1013 SHEET 3 AH7 5 ALAbb1086 TRPbb1093 -1 N TYRbb1088 O THRbb1107 SHEET 4 AH7 5 HISbb1036 HISbb1040 -1 N HISbb1040 O ASPbb1087 SHEET 5 AH7 5 VALbb1047 ILEbb1050 -1 O ILEbb1050 N TRPbb1037 SHEET 1 AH8 4 SERbb1012 SERbb1014 0 SHEET 2 AH8 4 THRbb1107 THRbb1110 1 O ARGbb1108 N VALbb1013 SHEET 3 AH8 4 ALAbb1086 TRPbb1093 -1 N TYRbb1088 O THRbb1107 SHEET 4 AH8 4 TYRbb1101 PHEbb1103 -1 O VALbb1102 N VALbb1092 SHEET 1 AH9 4 GLNbb1127 SERbb1131 0 SHEET 2 AH9 4 LEUbb1142 SERbb1149 -1 O ALAbb1147 N VALbb1129 SHEET 3 AH9 4 THRbb1202 METbb1207 -1 O METbb1207 N LEUbb1142 SHEET 4 AH9 4 PHEbb1192 ASPbb1197 -1 N THRbb1193 O GLNbb1206 SHEET 1 AI1 6 GLYbb1134 LEUbb1135 0 SHEET 2 AI1 6 THRbb1242 THRbb1245 1 O THRbb1245 N GLYbb1134 SHEET 3 AI1 6 ALAbb1216 LYSbb1222 -1 N TYRbb1218 O THRbb1242 SHEET 4 AI1 6 METbb1158 GLNbb1163 -1 N VALbb1161 O TYRbb1219 SHEET 5 AI1 6 LEUbb1169 ILEbb1175 -1 O GLUbb1170 N ARGbb1162 SHEET 6 AI1 6 THRbb1182 TYRbb1184 -1 O TYRbb1183 N SERbb1174 SHEET 1 AI2 4 GLYbb1134 LEUbb1135 0 SHEET 2 AI2 4 THRbb1242 THRbb1245 1 O THRbb1245 N GLYbb1134 SHEET 3 AI2 4 ALAbb1216 LYSbb1222 -1 N TYRbb1218 O THRbb1242 SHEET 4 AI2 4 TYRbb1237 TRPbb1238 -1 O TYRbb1237 N LYSbb1222 SHEET 1 AI3 4 LEUcc1007 THRcc1008 0 SHEET 2 AI3 4 ALAcc1021 GLYcc1027 -1 O GLYcc1026 N THRcc1008 SHEET 3 AI3 4 THRcc1072 ILEcc1077 -1 O ILEcc1077 N ALAcc1021 SHEET 4 AI3 4 VALcc1064 ASNcc1068 -1 N SERcc1065 O THRcc1076 SHEET 1 AI4 5 SERcc1012 VALcc1015 0 SHEET 2 AI4 5 THRcc1107 VALcc1111 1 O ARGcc1108 N VALcc1013 SHEET 3 AI4 5 ALAcc1086 TRPcc1093 -1 N TYRcc1088 O THRcc1107 SHEET 4 AI4 5 HIScc1036 HIScc1040 -1 N TYRcc1038 O TYRcc1089 SHEET 5 AI4 5 VALcc1047 ILEcc1050 -1 O ILEcc1050 N TRPcc1037 SHEET 1 AI5 4 SERcc1012 VALcc1015 0 SHEET 2 AI5 4 THRcc1107 VALcc1111 1 O ARGcc1108 N VALcc1013 SHEET 3 AI5 4 ALAcc1086 TRPcc1093 -1 N TYRcc1088 O THRcc1107 SHEET 4 AI5 4 TYRcc1101 PHEcc1103 -1 O VALcc1102 N VALcc1092 SHEET 1 AI6 4 GLNcc1127 SERcc1131 0 SHEET 2 AI6 4 LEUcc1142 SERcc1149 -1 O ALAcc1147 N VALcc1129 SHEET 3 AI6 4 THRcc1202 METcc1207 -1 O METcc1207 N LEUcc1142 SHEET 4 AI6 4 PHEcc1192 ASPcc1197 -1 N THRcc1193 O GLNcc1206 SHEET 1 AI7 6 GLYcc1134 LEUcc1135 0 SHEET 2 AI7 6 THRcc1242 THRcc1245 1 O THRcc1245 N GLYcc1134 SHEET 3 AI7 6 ALAcc1216 LYScc1222 -1 N ALAcc1216 O VALcc1244 SHEET 4 AI7 6 METcc1158 GLNcc1163 -1 N VALcc1161 O TYRcc1219 SHEET 5 AI7 6 LEUcc1169 ILEcc1175 -1 O GLUcc1170 N ARGcc1162 SHEET 6 AI7 6 THRcc1182 TYRcc1184 -1 O TYRcc1183 N SERcc1174 SHEET 1 AI8 4 GLYcc1134 LEUcc1135 0 SHEET 2 AI8 4 THRcc1242 THRcc1245 1 O THRcc1245 N GLYcc1134 SHEET 3 AI8 4 ALAcc1216 LYScc1222 -1 N ALAcc1216 O VALcc1244 SHEET 4 AI8 4 TYRcc1237 TRPcc1238 -1 O TYRcc1237 N LYScc1222 SHEET 1 AI9 4 LEUdd1007 THRdd1008 0 SHEET 2 AI9 4 ALAdd1021 GLYdd1027 -1 O GLYdd1026 N THRdd1008 SHEET 3 AI9 4 THRdd1072 ILEdd1077 -1 O ILEdd1077 N ALAdd1021 SHEET 4 AI9 4 VALdd1064 ASNdd1068 -1 N SERdd1065 O THRdd1076 SHEET 1 AJ1 5 SERdd1012 SERdd1014 0 SHEET 2 AJ1 5 THRdd1107 THRdd1110 1 O ARGdd1108 N VALdd1013 SHEET 3 AJ1 5 ALAdd1086 TRPdd1093 -1 N TYRdd1088 O THRdd1107 SHEET 4 AJ1 5 HISdd1036 HISdd1040 -1 N TYRdd1038 O TYRdd1089 SHEET 5 AJ1 5 VALdd1047 ILEdd1050 -1 O ILEdd1050 N TRPdd1037 SHEET 1 AJ2 4 SERdd1012 SERdd1014 0 SHEET 2 AJ2 4 THRdd1107 THRdd1110 1 O ARGdd1108 N VALdd1013 SHEET 3 AJ2 4 ALAdd1086 TRPdd1093 -1 N TYRdd1088 O THRdd1107 SHEET 4 AJ2 4 TYRdd1101 PHEdd1103 -1 O VALdd1102 N VALdd1092 SHEET 1 AJ3 4 GLNdd1127 SERdd1131 0 SHEET 2 AJ3 4 LEUdd1142 SERdd1149 -1 O ALAdd1147 N VALdd1129 SHEET 3 AJ3 4 THRdd1202 METdd1207 -1 O METdd1207 N LEUdd1142 SHEET 4 AJ3 4 PHEdd1192 ASPdd1197 -1 N THRdd1193 O GLNdd1206 SHEET 1 AJ4 6 GLYdd1134 LEUdd1135 0 SHEET 2 AJ4 6 THRdd1242 THRdd1245 1 O THRdd1245 N GLYdd1134 SHEET 3 AJ4 6 ALAdd1216 LYSdd1222 -1 N TYRdd1218 O THRdd1242 SHEET 4 AJ4 6 METdd1158 GLNdd1163 -1 N VALdd1161 O TYRdd1219 SHEET 5 AJ4 6 LEUdd1169 ILEdd1175 -1 O GLUdd1170 N ARGdd1162 SHEET 6 AJ4 6 THRdd1182 TYRdd1184 -1 O TYRdd1183 N SERdd1174 SHEET 1 AJ5 4 GLYdd1134 LEUdd1135 0 SHEET 2 AJ5 4 THRdd1242 THRdd1245 1 O THRdd1245 N GLYdd1134 SHEET 3 AJ5 4 ALAdd1216 LYSdd1222 -1 N TYRdd1218 O THRdd1242 SHEET 4 AJ5 4 TYRdd1237 TRPdd1238 -1 O TYRdd1237 N LYSdd1222 SHEET 1 AJ6 4 LEUee1007 THRee1008 0 SHEET 2 AJ6 4 ALAee1021 GLYee1027 -1 O GLYee1026 N THRee1008 SHEET 3 AJ6 4 THRee1072 ILEee1077 -1 O ILEee1077 N ALAee1021 SHEET 4 AJ6 4 VALee1064 ASNee1068 -1 N SERee1065 O THRee1076 SHEET 1 AJ7 5 SERee1012 VALee1015 0 SHEET 2 AJ7 5 THRee1107 VALee1111 1 O ARGee1108 N VALee1013 SHEET 3 AJ7 5 ALAee1086 TRPee1093 -1 N TYRee1088 O THRee1107 SHEET 4 AJ7 5 HISee1036 HISee1040 -1 N TYRee1038 O TYRee1089 SHEET 5 AJ7 5 VALee1047 ILEee1050 -1 O ILEee1050 N TRPee1037 SHEET 1 AJ8 4 SERee1012 VALee1015 0 SHEET 2 AJ8 4 THRee1107 VALee1111 1 O ARGee1108 N VALee1013 SHEET 3 AJ8 4 ALAee1086 TRPee1093 -1 N TYRee1088 O THRee1107 SHEET 4 AJ8 4 TYRee1101 PHEee1103 -1 O VALee1102 N VALee1092 SHEET 1 AJ9 4 GLNee1127 SERee1131 0 SHEET 2 AJ9 4 LEUee1142 SERee1149 -1 O ALAee1147 N VALee1129 SHEET 3 AJ9 4 THRee1202 METee1207 -1 O METee1207 N LEUee1142 SHEET 4 AJ9 4 PHEee1192 ASPee1197 -1 N THRee1193 O GLNee1206 SHEET 1 AK1 6 GLYee1134 LEUee1135 0 SHEET 2 AK1 6 THRee1242 THRee1245 1 O THRee1245 N GLYee1134 SHEET 3 AK1 6 ALAee1216 LYSee1222 -1 N TYRee1218 O THRee1242 SHEET 4 AK1 6 METee1158 GLNee1163 -1 N VALee1161 O TYRee1219 SHEET 5 AK1 6 LEUee1169 ILEee1175 -1 O GLUee1170 N ARGee1162 SHEET 6 AK1 6 THRee1182 TYRee1184 -1 O TYRee1183 N SERee1174 SHEET 1 AK2 4 GLYee1134 LEUee1135 0 SHEET 2 AK2 4 THRee1242 THRee1245 1 O THRee1245 N GLYee1134 SHEET 3 AK2 4 ALAee1216 LYSee1222 -1 N TYRee1218 O THRee1242 SHEET 4 AK2 4 TYRee1237 TRPee1238 -1 O TYRee1237 N LYSee1222 SHEET 1 AK3 4 LEUWW1007 THRWW1008 0 SHEET 2 AK3 4 ALAWW1021 GLYWW1027 -1 O GLYWW1026 N THRWW1008 SHEET 3 AK3 4 THRWW1072 ILEWW1077 -1 O ILEWW1077 N ALAWW1021 SHEET 4 AK3 4 VALWW1064 ASNWW1068 -1 N SERWW1065 O THRWW1076 SHEET 1 AK4 5 SERWW1012 VALWW1015 0 SHEET 2 AK4 5 THRWW1107 VALWW1111 1 O ARGWW1108 N VALWW1013 SHEET 3 AK4 5 ALAWW1086 TRPWW1093 -1 N TYRWW1088 O THRWW1107 SHEET 4 AK4 5 HISWW1036 HISWW1040 -1 N TYRWW1038 O TYRWW1089 SHEET 5 AK4 5 VALWW1047 ILEWW1050 -1 O ILEWW1050 N TRPWW1037 SHEET 1 AK5 4 SERWW1012 VALWW1015 0 SHEET 2 AK5 4 THRWW1107 VALWW1111 1 O ARGWW1108 N VALWW1013 SHEET 3 AK5 4 ALAWW1086 TRPWW1093 -1 N TYRWW1088 O THRWW1107 SHEET 4 AK5 4 TYRWW1101 PHEWW1103 -1 O VALWW1102 N VALWW1092 SHEET 1 AK6 4 GLNWW1127 SERWW1131 0 SHEET 2 AK6 4 LEUWW1142 SERWW1149 -1 O ALAWW1147 N VALWW1129 SHEET 3 AK6 4 THRWW1202 METWW1207 -1 O METWW1207 N LEUWW1142 SHEET 4 AK6 4 PHEWW1192 ASPWW1197 -1 N THRWW1193 O GLNWW1206 SHEET 1 AK7 6 GLYWW1134 LEUWW1135 0 SHEET 2 AK7 6 THRWW1242 THRWW1245 1 O THRWW1245 N GLYWW1134 SHEET 3 AK7 6 ALAWW1216 LYSWW1222 -1 N TYRWW1218 O THRWW1242 SHEET 4 AK7 6 METWW1158 GLNWW1163 -1 N VALWW1161 O TYRWW1219 SHEET 5 AK7 6 LEUWW1169 ILEWW1175 -1 O GLUWW1170 N ARGWW1162 SHEET 6 AK7 6 THRWW1182 TYRWW1184 -1 O TYRWW1183 N SERWW1174 SHEET 1 AK8 4 GLYWW1134 LEUWW1135 0 SHEET 2 AK8 4 THRWW1242 THRWW1245 1 O THRWW1245 N GLYWW1134 SHEET 3 AK8 4 ALAWW1216 LYSWW1222 -1 N TYRWW1218 O THRWW1242 SHEET 4 AK8 4 TYRWW1237 TRPWW1238 -1 O TYRWW1237 N LYSWW1222 SHEET 1 AK9 4 LEUXX1007 THRXX1008 0 SHEET 2 AK9 4 ALAXX1021 GLYXX1027 -1 O GLYXX1026 N THRXX1008 SHEET 3 AK9 4 THRXX1072 ILEXX1077 -1 O ILEXX1077 N ALAXX1021 SHEET 4 AK9 4 SERXX1065 ASNXX1068 -1 N SERXX1065 O THRXX1076 SHEET 1 AL1 4 VALXX1047 ILEXX1050 0 SHEET 2 AL1 4 HISXX1036 HISXX1040 -1 N TRPXX1037 O ILEXX1050 SHEET 3 AL1 4 ASPXX1087 TRPXX1093 -1 O ASPXX1087 N HISXX1040 SHEET 4 AL1 4 TYRXX1101 PHEXX1103 -1 O VALXX1102 N VALXX1092 SHEET 1 AL2 4 GLNXX1127 SERXX1131 0 SHEET 2 AL2 4 LEUXX1142 SERXX1149 -1 O ALAXX1147 N VALXX1129 SHEET 3 AL2 4 THRXX1202 METXX1207 -1 O LEUXX1203 N CYSXX1146 SHEET 4 AL2 4 PHEXX1192 ASPXX1197 -1 N THRXX1193 O GLNXX1206 SHEET 1 AL3 6 GLYXX1134 LEUXX1135 0 SHEET 2 AL3 6 LEUXX1243 THRXX1245 1 O THRXX1245 N GLYXX1134 SHEET 3 AL3 6 ALAXX1216 LYSXX1222 -1 N ALAXX1216 O VALXX1244 SHEET 4 AL3 6 METXX1158 GLNXX1163 -1 N VALXX1161 O TYRXX1219 SHEET 5 AL3 6 LEUXX1169 ILEXX1175 -1 O GLUXX1170 N ARGXX1162 SHEET 6 AL3 6 THRXX1182 TYRXX1184 -1 O TYRXX1183 N SERXX1174 SHEET 1 AL4 4 GLYXX1134 LEUXX1135 0 SHEET 2 AL4 4 LEUXX1243 THRXX1245 1 O THRXX1245 N GLYXX1134 SHEET 3 AL4 4 ALAXX1216 LYSXX1222 -1 N ALAXX1216 O VALXX1244 SHEET 4 AL4 4 TYRXX1237 TRPXX1238 -1 O TYRXX1237 N LYSXX1222 SHEET 1 AL5 4 LEUYY1007 THRYY1008 0 SHEET 2 AL5 4 ALAYY1021 GLYYY1027 -1 O GLYYY1026 N THRYY1008 SHEET 3 AL5 4 THRYY1072 ILEYY1077 -1 O ILEYY1077 N ALAYY1021 SHEET 4 AL5 4 VALYY1064 ASNYY1068 -1 N SERYY1065 O THRYY1076 SHEET 1 AL6 5 SERYY1012 VALYY1015 0 SHEET 2 AL6 5 THRYY1107 VALYY1111 1 O ARGYY1108 N VALYY1013 SHEET 3 AL6 5 ALAYY1086 TRPYY1093 -1 N TYRYY1088 O THRYY1107 SHEET 4 AL6 5 HISYY1036 HISYY1040 -1 N TYRYY1038 O TYRYY1089 SHEET 5 AL6 5 VALYY1047 ILEYY1050 -1 O ILEYY1050 N TRPYY1037 SHEET 1 AL7 4 SERYY1012 VALYY1015 0 SHEET 2 AL7 4 THRYY1107 VALYY1111 1 O ARGYY1108 N VALYY1013 SHEET 3 AL7 4 ALAYY1086 TRPYY1093 -1 N TYRYY1088 O THRYY1107 SHEET 4 AL7 4 TYRYY1101 PHEYY1103 -1 O VALYY1102 N VALYY1092 SHEET 1 AL8 4 GLNYY1127 SERYY1131 0 SHEET 2 AL8 4 LEUYY1142 SERYY1149 -1 O ALAYY1147 N VALYY1129 SHEET 3 AL8 4 THRYY1202 METYY1207 -1 O METYY1207 N LEUYY1142 SHEET 4 AL8 4 PHEYY1192 ASPYY1197 -1 N THRYY1193 O GLNYY1206 SHEET 1 AL9 6 GLYYY1134 LEUYY1135 0 SHEET 2 AL9 6 THRYY1242 THRYY1245 1 O THRYY1245 N GLYYY1134 SHEET 3 AL9 6 ALAYY1216 LYSYY1222 -1 N ALAYY1216 O VALYY1244 SHEET 4 AL9 6 METYY1158 GLNYY1163 -1 N VALYY1161 O TYRYY1219 SHEET 5 AL9 6 LEUYY1169 ILEYY1175 -1 O GLUYY1170 N ARGYY1162 SHEET 6 AL9 6 THRYY1182 TYRYY1184 -1 O TYRYY1183 N SERYY1174 SHEET 1 AM1 4 GLYYY1134 LEUYY1135 0 SHEET 2 AM1 4 THRYY1242 THRYY1245 1 O THRYY1245 N GLYYY1134 SHEET 3 AM1 4 ALAYY1216 LYSYY1222 -1 N ALAYY1216 O VALYY1244 SHEET 4 AM1 4 TYRYY1237 TRPYY1238 -1 O TYRYY1237 N LYSYY1222 SSBOND 1 CYSZZ 1025 CYSZZ 1090 1555 1555 2.03 SSBOND 2 CYSZZ 1146 CYSZZ 1220 1555 1555 2.07 SSBOND 3 CYSKK 1025 CYSKK 1090 1555 1555 2.03 SSBOND 4 CYSKK 1146 CYSKK 1220 1555 1555 2.10 SSBOND 5 CYSaa 1025 CYSaa 1090 1555 1555 2.05 SSBOND 6 CYSaa 1146 CYSaa 1220 1555 1555 2.07 SSBOND 7 CYSbb 1025 CYSbb 1090 1555 1555 2.05 SSBOND 8 CYSbb 1146 CYSbb 1220 1555 1555 2.06 SSBOND 9 CYScc 1025 CYScc 1090 1555 1555 2.03 SSBOND 10 CYScc 1146 CYScc 1220 1555 1555 2.09 SSBOND 11 CYSdd 1025 CYSdd 1090 1555 1555 2.04 SSBOND 12 CYSdd 1146 CYSdd 1220 1555 1555 2.07 SSBOND 13 CYSee 1025 CYSee 1090 1555 1555 2.03 SSBOND 14 CYSee 1146 CYSee 1220 1555 1555 2.08 SSBOND 15 CYSWW 1025 CYSWW 1090 1555 1555 2.03 SSBOND 16 CYSWW 1146 CYSWW 1220 1555 1555 2.10 SSBOND 17 CYSXX 1025 CYSXX 1090 1555 1555 2.03 SSBOND 18 CYSXX 1146 CYSXX 1220 1555 1555 2.06 SSBOND 19 CYSYY 1025 CYSYY 1090 1555 1555 2.03 SSBOND 20 CYSYY 1146 CYSYY 1220 1555 1555 2.08 CRYST1 124.127 172.530 159.710 90.00 104.53 90.00 P 1 21 1 20 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.008056 0.000000 0.002088 0.00000 SCALE2 0.000000 0.005796 0.000000 0.00000 SCALE3 0.000000 0.000000 0.006468 0.00000