HEADER MEMBRANE PROTEIN 03-AUG-21 7PBZ TITLE A1B3 GABA-A RECEPTOR + GABA + ZN2+ COMPND MOL_ID: 1; COMPND 2 MOLECULE: MEGABODY 25; COMPND 3 CHAIN: F; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1; COMPND 7 CHAIN: A; COMPND 8 SYNONYM: GABA(A) RECEPTOR SUBUNIT ALPHA-1,GABA(A) RECEPTOR SUBUNIT COMPND 9 ALPHA-1; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3; COMPND 13 CHAIN: B, C, E; COMPND 14 SYNONYM: GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNIT COMPND 15 BETA-3; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 4; COMPND 18 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1; COMPND 19 CHAIN: D; COMPND 20 SYNONYM: GABA(A) RECEPTOR SUBUNIT ALPHA-1,GABA(A) RECEPTOR SUBUNIT COMPND 21 ALPHA-1; COMPND 22 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: LAMA GLAMA; SOURCE 3 ORGANISM_TAXID: 9844; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_COMMON: HUMAN; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 GENE: GABRA1; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 GENE: GABRB3; SOURCE 18 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 20 MOL_ID: 4; SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 22 ORGANISM_COMMON: HUMAN; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 GENE: GABRA1; SOURCE 25 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS PLGIC GABA NEUROTRANSMISSION, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR P.S.MILLER,V.B.KASARAGOD JRNL AUTH V.B.KASARAGOD,M.MORTENSEN,S.W.HARDWICK,A.A.WAHID,V.DOROVYKH, JRNL AUTH 2 D.Y.CHIRGADZE,T.G.SMART,P.S.MILLER JRNL TITL MECHANISMS OF INHIBITION AND ACTIVATION OF EXTRASYNAPTIC JRNL TITL 2 ALPHA BETA GABAA RECEPTORS JRNL REF NATURE 2022 JRNL REFN ESSN 1476-4687 JRNL DOI 10.1038/S41586-022-04402-Z REMARK 2 REMARK 2 RESOLUTION. 2.79 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.790 REMARK 3 NUMBER OF PARTICLES : 92749 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 7PBZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE. REMARK 100 THE DEPOSITION ID IS D_1292116331. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : GABA-A RECEPTOR - MEGABODY 25 REMARK 245 COMPLEX REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.25 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : DIFFRACTION REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 46.90 REMARK 245 ILLUMINATION MODE : SPOT SCAN REMARK 245 NOMINAL MAGNIFICATION : 130000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: F, A, B, C, E, D, G, H, I, J, REMARK 350 AND CHAINS: K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLY F 9 REMARK 465 GLY F 10 REMARK 465 LEU F 11 REMARK 465 VAL F 12 REMARK 465 GLN F 13 REMARK 465 THR F 14 REMARK 465 LYS F 15 REMARK 465 THR F 16 REMARK 465 THR F 17 REMARK 465 THR F 18 REMARK 465 SER F 19 REMARK 465 VAL F 20 REMARK 465 ILE F 21 REMARK 465 ASP F 22 REMARK 465 THR F 23 REMARK 465 THR F 24 REMARK 465 ASN F 25 REMARK 465 ASP F 26 REMARK 465 ALA F 27 REMARK 465 GLN F 28 REMARK 465 ASN F 29 REMARK 465 LEU F 30 REMARK 465 LEU F 31 REMARK 465 THR F 32 REMARK 465 GLN F 33 REMARK 465 ALA F 34 REMARK 465 GLN F 35 REMARK 465 THR F 36 REMARK 465 ILE F 37 REMARK 465 VAL F 38 REMARK 465 ASN F 39 REMARK 465 THR F 40 REMARK 465 LEU F 41 REMARK 465 LYS F 42 REMARK 465 ASP F 43 REMARK 465 TYR F 44 REMARK 465 CYS F 45 REMARK 465 PRO F 46 REMARK 465 ILE F 47 REMARK 465 LEU F 48 REMARK 465 ILE F 49 REMARK 465 ALA F 50 REMARK 465 LYS F 51 REMARK 465 SER F 52 REMARK 465 SER F 53 REMARK 465 SER F 54 REMARK 465 SER F 55 REMARK 465 ASN F 56 REMARK 465 GLY F 57 REMARK 465 GLY F 58 REMARK 465 THR F 59 REMARK 465 ASN F 60 REMARK 465 ASN F 61 REMARK 465 ALA F 62 REMARK 465 ASN F 63 REMARK 465 THR F 64 REMARK 465 PRO F 65 REMARK 465 SER F 66 REMARK 465 TRP F 67 REMARK 465 GLN F 68 REMARK 465 THR F 69 REMARK 465 ALA F 70 REMARK 465 GLY F 71 REMARK 465 GLY F 72 REMARK 465 GLY F 73 REMARK 465 LYS F 74 REMARK 465 ASN F 75 REMARK 465 SER F 76 REMARK 465 CYS F 77 REMARK 465 ALA F 78 REMARK 465 THR F 79 REMARK 465 PHE F 80 REMARK 465 GLY F 81 REMARK 465 ALA F 82 REMARK 465 GLU F 83 REMARK 465 PHE F 84 REMARK 465 SER F 85 REMARK 465 ALA F 86 REMARK 465 ALA F 87 REMARK 465 SER F 88 REMARK 465 ASP F 89 REMARK 465 MET F 90 REMARK 465 ILE F 91 REMARK 465 ASN F 92 REMARK 465 ASN F 93 REMARK 465 ALA F 94 REMARK 465 GLN F 95 REMARK 465 LYS F 96 REMARK 465 ILE F 97 REMARK 465 VAL F 98 REMARK 465 GLN F 99 REMARK 465 GLU F 100 REMARK 465 THR F 101 REMARK 465 GLN F 102 REMARK 465 GLN F 103 REMARK 465 LEU F 104 REMARK 465 SER F 105 REMARK 465 ALA F 106 REMARK 465 ASN F 107 REMARK 465 GLN F 108 REMARK 465 PRO F 109 REMARK 465 LYS F 110 REMARK 465 ASN F 111 REMARK 465 ILE F 112 REMARK 465 THR F 113 REMARK 465 GLN F 114 REMARK 465 PRO F 115 REMARK 465 HIS F 116 REMARK 465 ASN F 117 REMARK 465 LEU F 118 REMARK 465 ASN F 119 REMARK 465 LEU F 120 REMARK 465 ASN F 121 REMARK 465 SER F 122 REMARK 465 PRO F 123 REMARK 465 SER F 124 REMARK 465 SER F 125 REMARK 465 LEU F 126 REMARK 465 THR F 127 REMARK 465 ALA F 128 REMARK 465 LEU F 129 REMARK 465 ALA F 130 REMARK 465 GLN F 131 REMARK 465 LYS F 132 REMARK 465 MET F 133 REMARK 465 LEU F 134 REMARK 465 LYS F 135 REMARK 465 ASN F 136 REMARK 465 ALA F 137 REMARK 465 GLN F 138 REMARK 465 SER F 139 REMARK 465 GLN F 140 REMARK 465 ALA F 141 REMARK 465 GLU F 142 REMARK 465 ILE F 143 REMARK 465 LEU F 144 REMARK 465 LYS F 145 REMARK 465 LEU F 146 REMARK 465 ALA F 147 REMARK 465 ASN F 148 REMARK 465 GLN F 149 REMARK 465 VAL F 150 REMARK 465 GLU F 151 REMARK 465 SER F 152 REMARK 465 ASP F 153 REMARK 465 PHE F 154 REMARK 465 ASN F 155 REMARK 465 LYS F 156 REMARK 465 LEU F 157 REMARK 465 SER F 158 REMARK 465 SER F 159 REMARK 465 GLY F 160 REMARK 465 HIS F 161 REMARK 465 LEU F 162 REMARK 465 LYS F 163 REMARK 465 ASP F 164 REMARK 465 TYR F 165 REMARK 465 ILE F 166 REMARK 465 GLY F 167 REMARK 465 LYS F 168 REMARK 465 CYS F 169 REMARK 465 ASP F 170 REMARK 465 ALA F 171 REMARK 465 SER F 172 REMARK 465 ALA F 173 REMARK 465 ILE F 174 REMARK 465 SER F 175 REMARK 465 SER F 176 REMARK 465 ALA F 177 REMARK 465 ASN F 178 REMARK 465 MET F 179 REMARK 465 THR F 180 REMARK 465 MET F 181 REMARK 465 GLN F 182 REMARK 465 ASN F 183 REMARK 465 GLN F 184 REMARK 465 LYS F 185 REMARK 465 ASN F 186 REMARK 465 ASN F 187 REMARK 465 TRP F 188 REMARK 465 GLY F 189 REMARK 465 ASN F 190 REMARK 465 GLY F 191 REMARK 465 CYS F 192 REMARK 465 ALA F 193 REMARK 465 GLY F 194 REMARK 465 VAL F 195 REMARK 465 GLU F 196 REMARK 465 GLU F 197 REMARK 465 THR F 198 REMARK 465 GLN F 199 REMARK 465 SER F 200 REMARK 465 LEU F 201 REMARK 465 LEU F 202 REMARK 465 LYS F 203 REMARK 465 THR F 204 REMARK 465 SER F 205 REMARK 465 ALA F 206 REMARK 465 ALA F 207 REMARK 465 ASP F 208 REMARK 465 PHE F 209 REMARK 465 ASN F 210 REMARK 465 ASN F 211 REMARK 465 GLN F 212 REMARK 465 THR F 213 REMARK 465 PRO F 214 REMARK 465 GLN F 215 REMARK 465 ILE F 216 REMARK 465 ASN F 217 REMARK 465 GLN F 218 REMARK 465 ALA F 219 REMARK 465 GLN F 220 REMARK 465 ASN F 221 REMARK 465 LEU F 222 REMARK 465 ALA F 223 REMARK 465 ASN F 224 REMARK 465 THR F 225 REMARK 465 LEU F 226 REMARK 465 ILE F 227 REMARK 465 GLN F 228 REMARK 465 GLU F 229 REMARK 465 LEU F 230 REMARK 465 GLY F 231 REMARK 465 ASN F 232 REMARK 465 ASN F 233 REMARK 465 THR F 234 REMARK 465 TYR F 235 REMARK 465 GLU F 236 REMARK 465 GLN F 237 REMARK 465 LEU F 238 REMARK 465 SER F 239 REMARK 465 ARG F 240 REMARK 465 LEU F 241 REMARK 465 LEU F 242 REMARK 465 THR F 243 REMARK 465 ASN F 244 REMARK 465 ASP F 245 REMARK 465 ASN F 246 REMARK 465 GLY F 247 REMARK 465 THR F 248 REMARK 465 ASN F 249 REMARK 465 SER F 250 REMARK 465 LYS F 251 REMARK 465 THR F 252 REMARK 465 SER F 253 REMARK 465 ALA F 254 REMARK 465 GLN F 255 REMARK 465 ALA F 256 REMARK 465 ILE F 257 REMARK 465 ASN F 258 REMARK 465 GLN F 259 REMARK 465 ALA F 260 REMARK 465 VAL F 261 REMARK 465 ASN F 262 REMARK 465 ASN F 263 REMARK 465 LEU F 264 REMARK 465 ASN F 265 REMARK 465 GLU F 266 REMARK 465 ARG F 267 REMARK 465 ALA F 268 REMARK 465 LYS F 269 REMARK 465 THR F 270 REMARK 465 LEU F 271 REMARK 465 ALA F 272 REMARK 465 GLY F 273 REMARK 465 GLY F 274 REMARK 465 THR F 275 REMARK 465 THR F 276 REMARK 465 ASN F 277 REMARK 465 SER F 278 REMARK 465 PRO F 279 REMARK 465 ALA F 280 REMARK 465 TYR F 281 REMARK 465 GLN F 282 REMARK 465 ALA F 283 REMARK 465 THR F 284 REMARK 465 LEU F 285 REMARK 465 LEU F 286 REMARK 465 ALA F 287 REMARK 465 LEU F 288 REMARK 465 ARG F 289 REMARK 465 SER F 290 REMARK 465 VAL F 291 REMARK 465 LEU F 292 REMARK 465 GLY F 293 REMARK 465 LEU F 294 REMARK 465 TRP F 295 REMARK 465 ASN F 296 REMARK 465 SER F 297 REMARK 465 MET F 298 REMARK 465 GLY F 299 REMARK 465 TYR F 300 REMARK 465 ALA F 301 REMARK 465 VAL F 302 REMARK 465 ILE F 303 REMARK 465 CYS F 304 REMARK 465 GLY F 305 REMARK 465 GLY F 306 REMARK 465 TYR F 307 REMARK 465 THR F 308 REMARK 465 LYS F 309 REMARK 465 SER F 310 REMARK 465 PRO F 311 REMARK 465 GLY F 312 REMARK 465 GLU F 313 REMARK 465 ASN F 314 REMARK 465 ASN F 315 REMARK 465 GLN F 316 REMARK 465 LYS F 317 REMARK 465 ASP F 318 REMARK 465 PHE F 319 REMARK 465 HIS F 320 REMARK 465 TYR F 321 REMARK 465 THR F 322 REMARK 465 ASP F 323 REMARK 465 GLU F 324 REMARK 465 ASN F 325 REMARK 465 GLY F 326 REMARK 465 ASN F 327 REMARK 465 GLY F 328 REMARK 465 THR F 329 REMARK 465 THR F 330 REMARK 465 ILE F 331 REMARK 465 ASN F 332 REMARK 465 CYS F 333 REMARK 465 GLY F 334 REMARK 465 GLY F 335 REMARK 465 SER F 336 REMARK 465 THR F 337 REMARK 465 ASN F 338 REMARK 465 SER F 339 REMARK 465 ASN F 340 REMARK 465 GLY F 341 REMARK 465 THR F 342 REMARK 465 HIS F 343 REMARK 465 SER F 344 REMARK 465 TYR F 345 REMARK 465 ASN F 346 REMARK 465 GLY F 347 REMARK 465 THR F 348 REMARK 465 ASN F 349 REMARK 465 THR F 350 REMARK 465 LEU F 351 REMARK 465 LYS F 352 REMARK 465 ALA F 353 REMARK 465 ASP F 354 REMARK 465 LYS F 355 REMARK 465 ASN F 356 REMARK 465 VAL F 357 REMARK 465 SER F 358 REMARK 465 LEU F 359 REMARK 465 SER F 360 REMARK 465 ILE F 361 REMARK 465 GLU F 362 REMARK 465 GLN F 363 REMARK 465 TYR F 364 REMARK 465 GLU F 365 REMARK 465 LYS F 366 REMARK 465 ILE F 367 REMARK 465 HIS F 368 REMARK 465 GLU F 369 REMARK 465 ALA F 370 REMARK 465 TYR F 371 REMARK 465 GLN F 372 REMARK 465 ILE F 373 REMARK 465 LEU F 374 REMARK 465 SER F 375 REMARK 465 LYS F 376 REMARK 465 ALA F 377 REMARK 465 LEU F 378 REMARK 465 LYS F 379 REMARK 465 GLN F 380 REMARK 465 ALA F 381 REMARK 465 GLY F 382 REMARK 465 LEU F 383 REMARK 465 ALA F 384 REMARK 465 PRO F 385 REMARK 465 LEU F 386 REMARK 465 ASN F 387 REMARK 465 SER F 388 REMARK 465 LYS F 389 REMARK 465 GLY F 390 REMARK 465 GLU F 391 REMARK 465 LYS F 392 REMARK 465 LEU F 393 REMARK 465 GLU F 394 REMARK 465 ALA F 395 REMARK 465 HIS F 396 REMARK 465 VAL F 397 REMARK 465 THR F 398 REMARK 465 THR F 399 REMARK 465 SER F 400 REMARK 465 LYS F 401 REMARK 465 TYR F 402 REMARK 465 GLY F 403 REMARK 465 SER F 404 REMARK 465 VAL F 510 REMARK 465 SER F 511 REMARK 465 SER F 512 REMARK 465 HIS F 513 REMARK 465 HIS F 514 REMARK 465 HIS F 515 REMARK 465 HIS F 516 REMARK 465 HIS F 517 REMARK 465 HIS F 518 REMARK 465 GLU F 519 REMARK 465 PRO F 520 REMARK 465 GLU F 521 REMARK 465 ALA F 522 REMARK 465 GLN A 2 REMARK 465 PRO A 3 REMARK 465 SER A 4 REMARK 465 GLN A 5 REMARK 465 ASP A 6 REMARK 465 GLU A 7 REMARK 465 LEU A 8 REMARK 465 LYS A 9 REMARK 465 ASP A 10 REMARK 465 ASN A 11 REMARK 465 ASN A 417 REMARK 465 ARG A 418 REMARK 465 GLU A 419 REMARK 465 PRO A 420 REMARK 465 GLN A 421 REMARK 465 LEU A 422 REMARK 465 LYS A 423 REMARK 465 ALA A 424 REMARK 465 PRO A 425 REMARK 465 THR A 426 REMARK 465 PRO A 427 REMARK 465 HIS A 428 REMARK 465 GLN A 429 REMARK 465 GLY A 430 REMARK 465 THR A 431 REMARK 465 THR A 432 REMARK 465 GLU A 433 REMARK 465 SER A 434 REMARK 465 THR A 435 REMARK 465 GLN A 436 REMARK 465 VAL A 437 REMARK 465 ALA A 438 REMARK 465 PRO A 439 REMARK 465 ALA A 440 REMARK 465 GLN B 1 REMARK 465 SER B 2 REMARK 465 VAL B 3 REMARK 465 ASN B 4 REMARK 465 ASP B 5 REMARK 465 PRO B 6 REMARK 465 GLY B 7 REMARK 465 GLN B 308A REMARK 465 PRO B 308B REMARK 465 ALA B 308C REMARK 465 GLY B 308D REMARK 465 THR B 308E REMARK 465 ALA B 308F REMARK 465 ASP B 308G REMARK 465 LEU B 308H REMARK 465 GLU B 308I REMARK 465 ASP B 308J REMARK 465 ASN B 308K REMARK 465 TRP B 308L REMARK 465 GLU B 308M REMARK 465 THR B 308N REMARK 465 LEU B 308O REMARK 465 ASN B 308P REMARK 465 ASP B 308Q REMARK 465 ASN B 308R REMARK 465 LEU B 308S REMARK 465 LYS B 308T REMARK 465 VAL B 308U REMARK 465 ILE B 308V REMARK 465 GLU B 308W REMARK 465 LYS B 308X REMARK 465 ALA B 308Y REMARK 465 ASP B 308Z REMARK 465 ASN B 309A REMARK 465 ALA B 309B REMARK 465 ALA B 309C REMARK 465 GLN B 309D REMARK 465 VAL B 309E REMARK 465 LYS B 309F REMARK 465 ASP B 309G REMARK 465 ALA B 309H REMARK 465 LEU B 309I REMARK 465 THR B 309J REMARK 465 LYS B 309K REMARK 465 MET B 309L REMARK 465 ARG B 309M REMARK 465 ALA B 309N REMARK 465 ALA B 309O REMARK 465 ALA B 309P REMARK 465 LEU B 309Q REMARK 465 ASP B 309R REMARK 465 ALA B 309S REMARK 465 GLN B 309T REMARK 465 LYS B 309U REMARK 465 ALA B 309V REMARK 465 THR B 309W REMARK 465 PRO B 309X REMARK 465 PRO B 309Y REMARK 465 LYS B 309Z REMARK 465 LEU B 310A REMARK 465 GLU B 310B REMARK 465 ASP B 310C REMARK 465 LYS B 310D REMARK 465 SER B 310E REMARK 465 PRO B 310F REMARK 465 ASP B 310G REMARK 465 SER B 310H REMARK 465 PRO B 310I REMARK 465 GLU B 310J REMARK 465 MET B 310K REMARK 465 LYS B 310L REMARK 465 ASP B 310M REMARK 465 PHE B 310N REMARK 465 ARG B 310O REMARK 465 HIS B 310P REMARK 465 GLY B 310Q REMARK 465 PHE B 310R REMARK 465 ASP B 310S REMARK 465 ILE B 310T REMARK 465 LEU B 310U REMARK 465 VAL B 310V REMARK 465 GLY B 310W REMARK 465 GLN B 310X REMARK 465 ILE B 310Y REMARK 465 ASP B 310Z REMARK 465 ASP B 311A REMARK 465 ALA B 311B REMARK 465 LEU B 311C REMARK 465 LYS B 311D REMARK 465 LEU B 311E REMARK 465 ALA B 311F REMARK 465 ASN B 311G REMARK 465 GLU B 311H REMARK 465 GLY B 311I REMARK 465 LYS B 311J REMARK 465 VAL B 311K REMARK 465 LYS B 311L REMARK 465 GLU B 311M REMARK 465 ALA B 311N REMARK 465 GLN B 311O REMARK 465 ALA B 311P REMARK 465 ALA B 311Q REMARK 465 ALA B 311R REMARK 465 GLU B 311S REMARK 465 GLN B 311T REMARK 465 LEU B 311U REMARK 465 LYS B 311V REMARK 465 THR B 311W REMARK 465 THR B 311X REMARK 465 ARG B 311Y REMARK 465 ASN B 311Z REMARK 465 ALA B 312A REMARK 465 TYR B 312B REMARK 465 ILE B 312C REMARK 465 GLN B 312D REMARK 465 LYS B 312E REMARK 465 TYR B 312F REMARK 465 LEU B 312G REMARK 465 THR B 312H REMARK 465 GLY B 312I REMARK 465 ASN B 448 REMARK 465 GLN C 1 REMARK 465 SER C 2 REMARK 465 VAL C 3 REMARK 465 ASN C 4 REMARK 465 ASP C 5 REMARK 465 PRO C 6 REMARK 465 GLY C 7 REMARK 465 GLN C 308A REMARK 465 PRO C 308B REMARK 465 ALA C 308C REMARK 465 GLY C 308D REMARK 465 THR C 308E REMARK 465 ALA C 308F REMARK 465 ASP C 308G REMARK 465 LEU C 308H REMARK 465 GLU C 308I REMARK 465 ASP C 308J REMARK 465 ASN C 308K REMARK 465 TRP C 308L REMARK 465 GLU C 308M REMARK 465 THR C 308N REMARK 465 LEU C 308O REMARK 465 ASN C 308P REMARK 465 ASP C 308Q REMARK 465 ASN C 308R REMARK 465 LEU C 308S REMARK 465 LYS C 308T REMARK 465 VAL C 308U REMARK 465 ILE C 308V REMARK 465 GLU C 308W REMARK 465 LYS C 308X REMARK 465 ALA C 308Y REMARK 465 ASP C 308Z REMARK 465 ASN C 309A REMARK 465 ALA C 309B REMARK 465 ALA C 309C REMARK 465 GLN C 309D REMARK 465 VAL C 309E REMARK 465 LYS C 309F REMARK 465 ASP C 309G REMARK 465 ALA C 309H REMARK 465 LEU C 309I REMARK 465 THR C 309J REMARK 465 LYS C 309K REMARK 465 MET C 309L REMARK 465 ARG C 309M REMARK 465 ALA C 309N REMARK 465 ALA C 309O REMARK 465 ALA C 309P REMARK 465 LEU C 309Q REMARK 465 ASP C 309R REMARK 465 ALA C 309S REMARK 465 GLN C 309T REMARK 465 LYS C 309U REMARK 465 ALA C 309V REMARK 465 THR C 309W REMARK 465 PRO C 309X REMARK 465 PRO C 309Y REMARK 465 LYS C 309Z REMARK 465 LEU C 310A REMARK 465 GLU C 310B REMARK 465 ASP C 310C REMARK 465 LYS C 310D REMARK 465 SER C 310E REMARK 465 PRO C 310F REMARK 465 ASP C 310G REMARK 465 SER C 310H REMARK 465 PRO C 310I REMARK 465 GLU C 310J REMARK 465 MET C 310K REMARK 465 LYS C 310L REMARK 465 ASP C 310M REMARK 465 PHE C 310N REMARK 465 ARG C 310O REMARK 465 HIS C 310P REMARK 465 GLY C 310Q REMARK 465 PHE C 310R REMARK 465 ASP C 310S REMARK 465 ILE C 310T REMARK 465 LEU C 310U REMARK 465 VAL C 310V REMARK 465 GLY C 310W REMARK 465 GLN C 310X REMARK 465 ILE C 310Y REMARK 465 ASP C 310Z REMARK 465 ASP C 311A REMARK 465 ALA C 311B REMARK 465 LEU C 311C REMARK 465 LYS C 311D REMARK 465 LEU C 311E REMARK 465 ALA C 311F REMARK 465 ASN C 311G REMARK 465 GLU C 311H REMARK 465 GLY C 311I REMARK 465 LYS C 311J REMARK 465 VAL C 311K REMARK 465 LYS C 311L REMARK 465 GLU C 311M REMARK 465 ALA C 311N REMARK 465 GLN C 311O REMARK 465 ALA C 311P REMARK 465 ALA C 311Q REMARK 465 ALA C 311R REMARK 465 GLU C 311S REMARK 465 GLN C 311T REMARK 465 LEU C 311U REMARK 465 LYS C 311V REMARK 465 THR C 311W REMARK 465 THR C 311X REMARK 465 ARG C 311Y REMARK 465 ASN C 311Z REMARK 465 ALA C 312A REMARK 465 TYR C 312B REMARK 465 ILE C 312C REMARK 465 GLN C 312D REMARK 465 LYS C 312E REMARK 465 TYR C 312F REMARK 465 LEU C 312G REMARK 465 THR C 312H REMARK 465 GLY C 312I REMARK 465 ASN C 448 REMARK 465 GLN E 1 REMARK 465 SER E 2 REMARK 465 VAL E 3 REMARK 465 ASN E 4 REMARK 465 ASP E 5 REMARK 465 PRO E 6 REMARK 465 GLY E 7 REMARK 465 GLN E 309 REMARK 465 PRO E 310 REMARK 465 ALA E 311 REMARK 465 GLY E 312 REMARK 465 THR E 313 REMARK 465 ALA E 314 REMARK 465 ASP E 315 REMARK 465 LEU E 316 REMARK 465 GLU E 317 REMARK 465 ASP E 318 REMARK 465 ASN E 319 REMARK 465 TRP E 320 REMARK 465 GLU E 321 REMARK 465 THR E 322 REMARK 465 LEU E 323 REMARK 465 ASN E 324 REMARK 465 ASP E 325 REMARK 465 ASN E 326 REMARK 465 LEU E 327 REMARK 465 LYS E 328 REMARK 465 VAL E 329 REMARK 465 ILE E 330 REMARK 465 GLU E 331 REMARK 465 LYS E 332 REMARK 465 ALA E 333 REMARK 465 ASP E 334 REMARK 465 ASN E 335 REMARK 465 ALA E 336 REMARK 465 ALA E 337 REMARK 465 GLN E 338 REMARK 465 VAL E 339 REMARK 465 LYS E 340 REMARK 465 ASP E 341 REMARK 465 ALA E 342 REMARK 465 LEU E 343 REMARK 465 THR E 344 REMARK 465 LYS E 345 REMARK 465 MET E 346 REMARK 465 ARG E 347 REMARK 465 ALA E 348 REMARK 465 ALA E 349 REMARK 465 ALA E 350 REMARK 465 LEU E 351 REMARK 465 ASP E 352 REMARK 465 ALA E 353 REMARK 465 GLN E 354 REMARK 465 LYS E 355 REMARK 465 ALA E 356 REMARK 465 THR E 357 REMARK 465 PRO E 358 REMARK 465 PRO E 359 REMARK 465 LYS E 360 REMARK 465 LEU E 361 REMARK 465 GLU E 362 REMARK 465 ASP E 363 REMARK 465 LYS E 364 REMARK 465 SER E 365 REMARK 465 PRO E 366 REMARK 465 ASP E 367 REMARK 465 SER E 368 REMARK 465 PRO E 369 REMARK 465 GLU E 370 REMARK 465 MET E 371 REMARK 465 LYS E 372 REMARK 465 ASP E 373 REMARK 465 PHE E 374 REMARK 465 ARG E 375 REMARK 465 HIS E 376 REMARK 465 GLY E 377 REMARK 465 PHE E 378 REMARK 465 ASP E 379 REMARK 465 ILE E 380 REMARK 465 LEU E 381 REMARK 465 VAL E 382 REMARK 465 GLY E 383 REMARK 465 GLN E 384 REMARK 465 ILE E 385 REMARK 465 ASP E 386 REMARK 465 ASP E 387 REMARK 465 ALA E 388 REMARK 465 LEU E 389 REMARK 465 LYS E 390 REMARK 465 LEU E 391 REMARK 465 ALA E 392 REMARK 465 ASN E 393 REMARK 465 GLU E 394 REMARK 465 GLY E 395 REMARK 465 LYS E 396 REMARK 465 VAL E 397 REMARK 465 LYS E 398 REMARK 465 GLU E 399 REMARK 465 ALA E 400 REMARK 465 GLN E 401 REMARK 465 ALA E 402 REMARK 465 ALA E 403 REMARK 465 ALA E 404 REMARK 465 GLU E 405 REMARK 465 GLN E 406 REMARK 465 LEU E 407 REMARK 465 LYS E 408 REMARK 465 THR E 409 REMARK 465 THR E 410 REMARK 465 ARG E 411 REMARK 465 ASN E 412 REMARK 465 ALA E 413 REMARK 465 TYR E 414 REMARK 465 ILE E 415 REMARK 465 GLN E 416 REMARK 465 LYS E 417 REMARK 465 TYR E 418 REMARK 465 LEU E 419 REMARK 465 THR E 420 REMARK 465 GLY E 421 REMARK 465 ASN E 451 REMARK 465 MET D -52 REMARK 465 ASP D -51 REMARK 465 GLU D -50 REMARK 465 LYS D -49 REMARK 465 THR D -48 REMARK 465 THR D -47 REMARK 465 GLY D -46 REMARK 465 TRP D -45 REMARK 465 ARG D -44 REMARK 465 GLY D -43 REMARK 465 GLY D -42 REMARK 465 HIS D -41 REMARK 465 VAL D -40 REMARK 465 VAL D -39 REMARK 465 GLU D -38 REMARK 465 GLY D -37 REMARK 465 LEU D -36 REMARK 465 ALA D -35 REMARK 465 GLY D -34 REMARK 465 GLU D -33 REMARK 465 LEU D -32 REMARK 465 GLU D -31 REMARK 465 GLN D -30 REMARK 465 LEU D -29 REMARK 465 ARG D -28 REMARK 465 ALA D -27 REMARK 465 ARG D -26 REMARK 465 LEU D -25 REMARK 465 GLU D -24 REMARK 465 HIS D -23 REMARK 465 HIS D -22 REMARK 465 PRO D -21 REMARK 465 GLN D -20 REMARK 465 GLY D -19 REMARK 465 GLN D -18 REMARK 465 ARG D -17 REMARK 465 GLU D -16 REMARK 465 PRO D -15 REMARK 465 ASP D -14 REMARK 465 TYR D -13 REMARK 465 ASP D -12 REMARK 465 ILE D -11 REMARK 465 PRO D -10 REMARK 465 THR D -9 REMARK 465 THR D -8 REMARK 465 GLU D -7 REMARK 465 ASN D -6 REMARK 465 LEU D -5 REMARK 465 TYR D -4 REMARK 465 PHE D -3 REMARK 465 GLN D -2 REMARK 465 GLY D -1 REMARK 465 THR D 0 REMARK 465 GLY D 1 REMARK 465 GLN D 2 REMARK 465 PRO D 3 REMARK 465 SER D 4 REMARK 465 GLN D 5 REMARK 465 ASP D 6 REMARK 465 GLU D 7 REMARK 465 LEU D 8 REMARK 465 LYS D 9 REMARK 465 ASP D 10 REMARK 465 ASN D 11 REMARK 465 GLU D 419 REMARK 465 PRO D 420 REMARK 465 GLN D 421 REMARK 465 LEU D 422 REMARK 465 LYS D 423 REMARK 465 ALA D 424 REMARK 465 PRO D 425 REMARK 465 THR D 426 REMARK 465 PRO D 427 REMARK 465 HIS D 428 REMARK 465 GLN D 429 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 SER B 308 CB OG REMARK 470 SER C 308 CB OG REMARK 470 SER E 308 CB OG REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O4 NAG J 1 O5 NAG J 2 1.71 REMARK 500 O4 NAG H 1 O5 NAG H 2 1.98 REMARK 500 O4 NAG H 2 C2 BMA H 3 2.12 REMARK 500 OG1 THR B 160 OD1 ASP B 162 2.14 REMARK 500 O THR A 99 OG1 THR E 110 2.15 REMARK 500 O THR E 233 OG SER E 236 2.17 REMARK 500 OG SER E 104 O THR E 131 2.17 REMARK 500 OG1 THR A 113 O THR B 96 2.18 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS E 150 CA - CB - SG ANGL. DEV. = 14.6 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER F 490 20.96 -143.44 REMARK 500 ASP A 98 52.97 -90.69 REMARK 500 MET A 112 96.22 -69.97 REMARK 500 THR A 113 -16.01 74.53 REMARK 500 SER A 186 -62.52 -90.66 REMARK 500 LEU A 194 52.83 -91.11 REMARK 500 THR B 110 -18.81 74.24 REMARK 500 LEU B 145 33.00 -96.44 REMARK 500 ASN B 243 -169.60 -171.44 REMARK 500 VAL B 430 -50.78 -126.57 REMARK 500 ASP C 95 37.08 -98.77 REMARK 500 THR C 110 -22.21 75.39 REMARK 500 PRO C 276 70.93 -68.91 REMARK 500 THR E 110 -14.75 74.20 REMARK 500 PRO E 144 32.12 -93.04 REMARK 500 ASN D 111 39.02 -141.83 REMARK 500 THR D 113 -17.04 74.70 REMARK 500 LEU D 143 35.59 -98.27 REMARK 500 ARG D 187 17.98 58.76 REMARK 500 LEU D 194 53.17 -92.46 REMARK 500 ALA D 281 58.01 -94.07 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG E 269 0.09 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN B 503 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 HIS B 267 NE2 REMARK 620 2 HIS C 267 NE2 91.0 REMARK 620 3 HIS E 267 NE2 102.9 157.2 REMARK 620 N 1 2 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-13314 RELATED DB: EMDB REMARK 900 A1B3 GABA-A RECEPTOR + GABA DBREF 7PBZ F 1 522 PDB 7PBZ 7PBZ 1 522 DBREF 7PBZ A 5 312 UNP P14867 GBRA1_HUMAN 32 339 DBREF 7PBZ A 391 429 UNP P14867 GBRA1_HUMAN 418 456 DBREF 7PBZ B 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 7PBZ B 422 448 UNP P28472 GBRB3_HUMAN 447 473 DBREF 7PBZ C 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 7PBZ C 422 448 UNP P28472 GBRB3_HUMAN 447 473 DBREF 7PBZ E 1 307 UNP P28472 GBRB3_HUMAN 26 332 DBREF 7PBZ E 425 451 UNP P28472 GBRB3_HUMAN 447 473 DBREF 7PBZ D 5 312 UNP P14867 GBRA1_HUMAN 32 339 DBREF 7PBZ D 391 429 UNP P14867 GBRA1_HUMAN 418 456 SEQADV 7PBZ GLN A 2 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO A 3 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER A 4 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER A 313 UNP P14867 LINKER SEQADV 7PBZ GLN A 314 UNP P14867 LINKER SEQADV 7PBZ PRO A 315 UNP P14867 LINKER SEQADV 7PBZ ALA A 316 UNP P14867 LINKER SEQADV 7PBZ ARG A 317 UNP P14867 LINKER SEQADV 7PBZ ALA A 318 UNP P14867 LINKER SEQADV 7PBZ ALA A 319 UNP P14867 LINKER SEQADV 7PBZ GLY A 430 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR A 431 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR A 432 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU A 433 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER A 434 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR A 435 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN A 436 UNP P14867 EXPRESSION TAG SEQADV 7PBZ VAL A 437 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ALA A 438 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO A 439 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ALA A 440 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER B 308 UNP P28472 LINKER SEQADV 7PBZ GLN B 308A UNP P28472 LINKER SEQADV 7PBZ PRO B 308B UNP P28472 LINKER SEQADV 7PBZ ALA B 308C UNP P28472 LINKER SEQADV 7PBZ GLY B 308D UNP P28472 LINKER SEQADV 7PBZ THR B 308E UNP P28472 LINKER SEQADV 7PBZ ALA B 308F UNP P28472 LINKER SEQADV 7PBZ ASP B 308G UNP P28472 LINKER SEQADV 7PBZ LEU B 308H UNP P28472 LINKER SEQADV 7PBZ GLU B 308I UNP P28472 LINKER SEQADV 7PBZ ASP B 308J UNP P28472 LINKER SEQADV 7PBZ ASN B 308K UNP P28472 LINKER SEQADV 7PBZ TRP B 308L UNP P28472 LINKER SEQADV 7PBZ GLU B 308M UNP P28472 LINKER SEQADV 7PBZ THR B 308N UNP P28472 LINKER SEQADV 7PBZ LEU B 308O UNP P28472 LINKER SEQADV 7PBZ ASN B 308P UNP P28472 LINKER SEQADV 7PBZ ASP B 308Q UNP P28472 LINKER SEQADV 7PBZ ASN B 308R UNP P28472 LINKER SEQADV 7PBZ LEU B 308S UNP P28472 LINKER SEQADV 7PBZ LYS B 308T UNP P28472 LINKER SEQADV 7PBZ VAL B 308U UNP P28472 LINKER SEQADV 7PBZ ILE B 308V UNP P28472 LINKER SEQADV 7PBZ GLU B 308W UNP P28472 LINKER SEQADV 7PBZ LYS B 308X UNP P28472 LINKER SEQADV 7PBZ ALA B 308Y UNP P28472 LINKER SEQADV 7PBZ ASP B 308Z UNP P28472 LINKER SEQADV 7PBZ ASN B 309A UNP P28472 LINKER SEQADV 7PBZ ALA B 309B UNP P28472 LINKER SEQADV 7PBZ ALA B 309C UNP P28472 LINKER SEQADV 7PBZ GLN B 309D UNP P28472 LINKER SEQADV 7PBZ VAL B 309E UNP P28472 LINKER SEQADV 7PBZ LYS B 309F UNP P28472 LINKER SEQADV 7PBZ ASP B 309G UNP P28472 LINKER SEQADV 7PBZ ALA B 309H UNP P28472 LINKER SEQADV 7PBZ LEU B 309I UNP P28472 LINKER SEQADV 7PBZ THR B 309J UNP P28472 LINKER SEQADV 7PBZ LYS B 309K UNP P28472 LINKER SEQADV 7PBZ MET B 309L UNP P28472 LINKER SEQADV 7PBZ ARG B 309M UNP P28472 LINKER SEQADV 7PBZ ALA B 309N UNP P28472 LINKER SEQADV 7PBZ ALA B 309O UNP P28472 LINKER SEQADV 7PBZ ALA B 309P UNP P28472 LINKER SEQADV 7PBZ LEU B 309Q UNP P28472 LINKER SEQADV 7PBZ ASP B 309R UNP P28472 LINKER SEQADV 7PBZ ALA B 309S UNP P28472 LINKER SEQADV 7PBZ GLN B 309T UNP P28472 LINKER SEQADV 7PBZ LYS B 309U UNP P28472 LINKER SEQADV 7PBZ ALA B 309V UNP P28472 LINKER SEQADV 7PBZ THR B 309W UNP P28472 LINKER SEQADV 7PBZ PRO B 309X UNP P28472 LINKER SEQADV 7PBZ PRO B 309Y UNP P28472 LINKER SEQADV 7PBZ LYS B 309Z UNP P28472 LINKER SEQADV 7PBZ LEU B 310A UNP P28472 LINKER SEQADV 7PBZ GLU B 310B UNP P28472 LINKER SEQADV 7PBZ ASP B 310C UNP P28472 LINKER SEQADV 7PBZ LYS B 310D UNP P28472 LINKER SEQADV 7PBZ SER B 310E UNP P28472 LINKER SEQADV 7PBZ PRO B 310F UNP P28472 LINKER SEQADV 7PBZ ASP B 310G UNP P28472 LINKER SEQADV 7PBZ SER B 310H UNP P28472 LINKER SEQADV 7PBZ PRO B 310I UNP P28472 LINKER SEQADV 7PBZ GLU B 310J UNP P28472 LINKER SEQADV 7PBZ MET B 310K UNP P28472 LINKER SEQADV 7PBZ LYS B 310L UNP P28472 LINKER SEQADV 7PBZ ASP B 310M UNP P28472 LINKER SEQADV 7PBZ PHE B 310N UNP P28472 LINKER SEQADV 7PBZ ARG B 310O UNP P28472 LINKER SEQADV 7PBZ HIS B 310P UNP P28472 LINKER SEQADV 7PBZ GLY B 310Q UNP P28472 LINKER SEQADV 7PBZ PHE B 310R UNP P28472 LINKER SEQADV 7PBZ ASP B 310S UNP P28472 LINKER SEQADV 7PBZ ILE B 310T UNP P28472 LINKER SEQADV 7PBZ LEU B 310U UNP P28472 LINKER SEQADV 7PBZ VAL B 310V UNP P28472 LINKER SEQADV 7PBZ GLY B 310W UNP P28472 LINKER SEQADV 7PBZ GLN B 310X UNP P28472 LINKER SEQADV 7PBZ ILE B 310Y UNP P28472 LINKER SEQADV 7PBZ ASP B 310Z UNP P28472 LINKER SEQADV 7PBZ ASP B 311A UNP P28472 LINKER SEQADV 7PBZ ALA B 311B UNP P28472 LINKER SEQADV 7PBZ LEU B 311C UNP P28472 LINKER SEQADV 7PBZ LYS B 311D UNP P28472 LINKER SEQADV 7PBZ LEU B 311E UNP P28472 LINKER SEQADV 7PBZ ALA B 311F UNP P28472 LINKER SEQADV 7PBZ ASN B 311G UNP P28472 LINKER SEQADV 7PBZ GLU B 311H UNP P28472 LINKER SEQADV 7PBZ GLY B 311I UNP P28472 LINKER SEQADV 7PBZ LYS B 311J UNP P28472 LINKER SEQADV 7PBZ VAL B 311K UNP P28472 LINKER SEQADV 7PBZ LYS B 311L UNP P28472 LINKER SEQADV 7PBZ GLU B 311M UNP P28472 LINKER SEQADV 7PBZ ALA B 311N UNP P28472 LINKER SEQADV 7PBZ GLN B 311O UNP P28472 LINKER SEQADV 7PBZ ALA B 311P UNP P28472 LINKER SEQADV 7PBZ ALA B 311Q UNP P28472 LINKER SEQADV 7PBZ ALA B 311R UNP P28472 LINKER SEQADV 7PBZ GLU B 311S UNP P28472 LINKER SEQADV 7PBZ GLN B 311T UNP P28472 LINKER SEQADV 7PBZ LEU B 311U UNP P28472 LINKER SEQADV 7PBZ LYS B 311V UNP P28472 LINKER SEQADV 7PBZ THR B 311W UNP P28472 LINKER SEQADV 7PBZ THR B 311X UNP P28472 LINKER SEQADV 7PBZ ARG B 311Y UNP P28472 LINKER SEQADV 7PBZ ASN B 311Z UNP P28472 LINKER SEQADV 7PBZ ALA B 312A UNP P28472 LINKER SEQADV 7PBZ TYR B 312B UNP P28472 LINKER SEQADV 7PBZ ILE B 312C UNP P28472 LINKER SEQADV 7PBZ GLN B 312D UNP P28472 LINKER SEQADV 7PBZ LYS B 312E UNP P28472 LINKER SEQADV 7PBZ TYR B 312F UNP P28472 LINKER SEQADV 7PBZ LEU B 312G UNP P28472 LINKER SEQADV 7PBZ THR B 312H UNP P28472 LINKER SEQADV 7PBZ GLY B 312I UNP P28472 LINKER SEQADV 7PBZ ARG B 419 UNP P28472 LINKER SEQADV 7PBZ ALA B 420 UNP P28472 LINKER SEQADV 7PBZ ALA B 421 UNP P28472 LINKER SEQADV 7PBZ SER C 308 UNP P28472 LINKER SEQADV 7PBZ GLN C 308A UNP P28472 LINKER SEQADV 7PBZ PRO C 308B UNP P28472 LINKER SEQADV 7PBZ ALA C 308C UNP P28472 LINKER SEQADV 7PBZ GLY C 308D UNP P28472 LINKER SEQADV 7PBZ THR C 308E UNP P28472 LINKER SEQADV 7PBZ ALA C 308F UNP P28472 LINKER SEQADV 7PBZ ASP C 308G UNP P28472 LINKER SEQADV 7PBZ LEU C 308H UNP P28472 LINKER SEQADV 7PBZ GLU C 308I UNP P28472 LINKER SEQADV 7PBZ ASP C 308J UNP P28472 LINKER SEQADV 7PBZ ASN C 308K UNP P28472 LINKER SEQADV 7PBZ TRP C 308L UNP P28472 LINKER SEQADV 7PBZ GLU C 308M UNP P28472 LINKER SEQADV 7PBZ THR C 308N UNP P28472 LINKER SEQADV 7PBZ LEU C 308O UNP P28472 LINKER SEQADV 7PBZ ASN C 308P UNP P28472 LINKER SEQADV 7PBZ ASP C 308Q UNP P28472 LINKER SEQADV 7PBZ ASN C 308R UNP P28472 LINKER SEQADV 7PBZ LEU C 308S UNP P28472 LINKER SEQADV 7PBZ LYS C 308T UNP P28472 LINKER SEQADV 7PBZ VAL C 308U UNP P28472 LINKER SEQADV 7PBZ ILE C 308V UNP P28472 LINKER SEQADV 7PBZ GLU C 308W UNP P28472 LINKER SEQADV 7PBZ LYS C 308X UNP P28472 LINKER SEQADV 7PBZ ALA C 308Y UNP P28472 LINKER SEQADV 7PBZ ASP C 308Z UNP P28472 LINKER SEQADV 7PBZ ASN C 309A UNP P28472 LINKER SEQADV 7PBZ ALA C 309B UNP P28472 LINKER SEQADV 7PBZ ALA C 309C UNP P28472 LINKER SEQADV 7PBZ GLN C 309D UNP P28472 LINKER SEQADV 7PBZ VAL C 309E UNP P28472 LINKER SEQADV 7PBZ LYS C 309F UNP P28472 LINKER SEQADV 7PBZ ASP C 309G UNP P28472 LINKER SEQADV 7PBZ ALA C 309H UNP P28472 LINKER SEQADV 7PBZ LEU C 309I UNP P28472 LINKER SEQADV 7PBZ THR C 309J UNP P28472 LINKER SEQADV 7PBZ LYS C 309K UNP P28472 LINKER SEQADV 7PBZ MET C 309L UNP P28472 LINKER SEQADV 7PBZ ARG C 309M UNP P28472 LINKER SEQADV 7PBZ ALA C 309N UNP P28472 LINKER SEQADV 7PBZ ALA C 309O UNP P28472 LINKER SEQADV 7PBZ ALA C 309P UNP P28472 LINKER SEQADV 7PBZ LEU C 309Q UNP P28472 LINKER SEQADV 7PBZ ASP C 309R UNP P28472 LINKER SEQADV 7PBZ ALA C 309S UNP P28472 LINKER SEQADV 7PBZ GLN C 309T UNP P28472 LINKER SEQADV 7PBZ LYS C 309U UNP P28472 LINKER SEQADV 7PBZ ALA C 309V UNP P28472 LINKER SEQADV 7PBZ THR C 309W UNP P28472 LINKER SEQADV 7PBZ PRO C 309X UNP P28472 LINKER SEQADV 7PBZ PRO C 309Y UNP P28472 LINKER SEQADV 7PBZ LYS C 309Z UNP P28472 LINKER SEQADV 7PBZ LEU C 310A UNP P28472 LINKER SEQADV 7PBZ GLU C 310B UNP P28472 LINKER SEQADV 7PBZ ASP C 310C UNP P28472 LINKER SEQADV 7PBZ LYS C 310D UNP P28472 LINKER SEQADV 7PBZ SER C 310E UNP P28472 LINKER SEQADV 7PBZ PRO C 310F UNP P28472 LINKER SEQADV 7PBZ ASP C 310G UNP P28472 LINKER SEQADV 7PBZ SER C 310H UNP P28472 LINKER SEQADV 7PBZ PRO C 310I UNP P28472 LINKER SEQADV 7PBZ GLU C 310J UNP P28472 LINKER SEQADV 7PBZ MET C 310K UNP P28472 LINKER SEQADV 7PBZ LYS C 310L UNP P28472 LINKER SEQADV 7PBZ ASP C 310M UNP P28472 LINKER SEQADV 7PBZ PHE C 310N UNP P28472 LINKER SEQADV 7PBZ ARG C 310O UNP P28472 LINKER SEQADV 7PBZ HIS C 310P UNP P28472 LINKER SEQADV 7PBZ GLY C 310Q UNP P28472 LINKER SEQADV 7PBZ PHE C 310R UNP P28472 LINKER SEQADV 7PBZ ASP C 310S UNP P28472 LINKER SEQADV 7PBZ ILE C 310T UNP P28472 LINKER SEQADV 7PBZ LEU C 310U UNP P28472 LINKER SEQADV 7PBZ VAL C 310V UNP P28472 LINKER SEQADV 7PBZ GLY C 310W UNP P28472 LINKER SEQADV 7PBZ GLN C 310X UNP P28472 LINKER SEQADV 7PBZ ILE C 310Y UNP P28472 LINKER SEQADV 7PBZ ASP C 310Z UNP P28472 LINKER SEQADV 7PBZ ASP C 311A UNP P28472 LINKER SEQADV 7PBZ ALA C 311B UNP P28472 LINKER SEQADV 7PBZ LEU C 311C UNP P28472 LINKER SEQADV 7PBZ LYS C 311D UNP P28472 LINKER SEQADV 7PBZ LEU C 311E UNP P28472 LINKER SEQADV 7PBZ ALA C 311F UNP P28472 LINKER SEQADV 7PBZ ASN C 311G UNP P28472 LINKER SEQADV 7PBZ GLU C 311H UNP P28472 LINKER SEQADV 7PBZ GLY C 311I UNP P28472 LINKER SEQADV 7PBZ LYS C 311J UNP P28472 LINKER SEQADV 7PBZ VAL C 311K UNP P28472 LINKER SEQADV 7PBZ LYS C 311L UNP P28472 LINKER SEQADV 7PBZ GLU C 311M UNP P28472 LINKER SEQADV 7PBZ ALA C 311N UNP P28472 LINKER SEQADV 7PBZ GLN C 311O UNP P28472 LINKER SEQADV 7PBZ ALA C 311P UNP P28472 LINKER SEQADV 7PBZ ALA C 311Q UNP P28472 LINKER SEQADV 7PBZ ALA C 311R UNP P28472 LINKER SEQADV 7PBZ GLU C 311S UNP P28472 LINKER SEQADV 7PBZ GLN C 311T UNP P28472 LINKER SEQADV 7PBZ LEU C 311U UNP P28472 LINKER SEQADV 7PBZ LYS C 311V UNP P28472 LINKER SEQADV 7PBZ THR C 311W UNP P28472 LINKER SEQADV 7PBZ THR C 311X UNP P28472 LINKER SEQADV 7PBZ ARG C 311Y UNP P28472 LINKER SEQADV 7PBZ ASN C 311Z UNP P28472 LINKER SEQADV 7PBZ ALA C 312A UNP P28472 LINKER SEQADV 7PBZ TYR C 312B UNP P28472 LINKER SEQADV 7PBZ ILE C 312C UNP P28472 LINKER SEQADV 7PBZ GLN C 312D UNP P28472 LINKER SEQADV 7PBZ LYS C 312E UNP P28472 LINKER SEQADV 7PBZ TYR C 312F UNP P28472 LINKER SEQADV 7PBZ LEU C 312G UNP P28472 LINKER SEQADV 7PBZ THR C 312H UNP P28472 LINKER SEQADV 7PBZ GLY C 312I UNP P28472 LINKER SEQADV 7PBZ ARG C 419 UNP P28472 LINKER SEQADV 7PBZ ALA C 420 UNP P28472 LINKER SEQADV 7PBZ ALA C 421 UNP P28472 LINKER SEQADV 7PBZ SER E 308 UNP P28472 LINKER SEQADV 7PBZ GLN E 309 UNP P28472 LINKER SEQADV 7PBZ PRO E 310 UNP P28472 LINKER SEQADV 7PBZ ALA E 311 UNP P28472 LINKER SEQADV 7PBZ GLY E 312 UNP P28472 LINKER SEQADV 7PBZ THR E 313 UNP P28472 LINKER SEQADV 7PBZ ALA E 314 UNP P28472 LINKER SEQADV 7PBZ ASP E 315 UNP P28472 LINKER SEQADV 7PBZ LEU E 316 UNP P28472 LINKER SEQADV 7PBZ GLU E 317 UNP P28472 LINKER SEQADV 7PBZ ASP E 318 UNP P28472 LINKER SEQADV 7PBZ ASN E 319 UNP P28472 LINKER SEQADV 7PBZ TRP E 320 UNP P28472 LINKER SEQADV 7PBZ GLU E 321 UNP P28472 LINKER SEQADV 7PBZ THR E 322 UNP P28472 LINKER SEQADV 7PBZ LEU E 323 UNP P28472 LINKER SEQADV 7PBZ ASN E 324 UNP P28472 LINKER SEQADV 7PBZ ASP E 325 UNP P28472 LINKER SEQADV 7PBZ ASN E 326 UNP P28472 LINKER SEQADV 7PBZ LEU E 327 UNP P28472 LINKER SEQADV 7PBZ LYS E 328 UNP P28472 LINKER SEQADV 7PBZ VAL E 329 UNP P28472 LINKER SEQADV 7PBZ ILE E 330 UNP P28472 LINKER SEQADV 7PBZ GLU E 331 UNP P28472 LINKER SEQADV 7PBZ LYS E 332 UNP P28472 LINKER SEQADV 7PBZ ALA E 333 UNP P28472 LINKER SEQADV 7PBZ ASP E 334 UNP P28472 LINKER SEQADV 7PBZ ASN E 335 UNP P28472 LINKER SEQADV 7PBZ ALA E 336 UNP P28472 LINKER SEQADV 7PBZ ALA E 337 UNP P28472 LINKER SEQADV 7PBZ GLN E 338 UNP P28472 LINKER SEQADV 7PBZ VAL E 339 UNP P28472 LINKER SEQADV 7PBZ LYS E 340 UNP P28472 LINKER SEQADV 7PBZ ASP E 341 UNP P28472 LINKER SEQADV 7PBZ ALA E 342 UNP P28472 LINKER SEQADV 7PBZ LEU E 343 UNP P28472 LINKER SEQADV 7PBZ THR E 344 UNP P28472 LINKER SEQADV 7PBZ LYS E 345 UNP P28472 LINKER SEQADV 7PBZ MET E 346 UNP P28472 LINKER SEQADV 7PBZ ARG E 347 UNP P28472 LINKER SEQADV 7PBZ ALA E 348 UNP P28472 LINKER SEQADV 7PBZ ALA E 349 UNP P28472 LINKER SEQADV 7PBZ ALA E 350 UNP P28472 LINKER SEQADV 7PBZ LEU E 351 UNP P28472 LINKER SEQADV 7PBZ ASP E 352 UNP P28472 LINKER SEQADV 7PBZ ALA E 353 UNP P28472 LINKER SEQADV 7PBZ GLN E 354 UNP P28472 LINKER SEQADV 7PBZ LYS E 355 UNP P28472 LINKER SEQADV 7PBZ ALA E 356 UNP P28472 LINKER SEQADV 7PBZ THR E 357 UNP P28472 LINKER SEQADV 7PBZ PRO E 358 UNP P28472 LINKER SEQADV 7PBZ PRO E 359 UNP P28472 LINKER SEQADV 7PBZ LYS E 360 UNP P28472 LINKER SEQADV 7PBZ LEU E 361 UNP P28472 LINKER SEQADV 7PBZ GLU E 362 UNP P28472 LINKER SEQADV 7PBZ ASP E 363 UNP P28472 LINKER SEQADV 7PBZ LYS E 364 UNP P28472 LINKER SEQADV 7PBZ SER E 365 UNP P28472 LINKER SEQADV 7PBZ PRO E 366 UNP P28472 LINKER SEQADV 7PBZ ASP E 367 UNP P28472 LINKER SEQADV 7PBZ SER E 368 UNP P28472 LINKER SEQADV 7PBZ PRO E 369 UNP P28472 LINKER SEQADV 7PBZ GLU E 370 UNP P28472 LINKER SEQADV 7PBZ MET E 371 UNP P28472 LINKER SEQADV 7PBZ LYS E 372 UNP P28472 LINKER SEQADV 7PBZ ASP E 373 UNP P28472 LINKER SEQADV 7PBZ PHE E 374 UNP P28472 LINKER SEQADV 7PBZ ARG E 375 UNP P28472 LINKER SEQADV 7PBZ HIS E 376 UNP P28472 LINKER SEQADV 7PBZ GLY E 377 UNP P28472 LINKER SEQADV 7PBZ PHE E 378 UNP P28472 LINKER SEQADV 7PBZ ASP E 379 UNP P28472 LINKER SEQADV 7PBZ ILE E 380 UNP P28472 LINKER SEQADV 7PBZ LEU E 381 UNP P28472 LINKER SEQADV 7PBZ VAL E 382 UNP P28472 LINKER SEQADV 7PBZ GLY E 383 UNP P28472 LINKER SEQADV 7PBZ GLN E 384 UNP P28472 LINKER SEQADV 7PBZ ILE E 385 UNP P28472 LINKER SEQADV 7PBZ ASP E 386 UNP P28472 LINKER SEQADV 7PBZ ASP E 387 UNP P28472 LINKER SEQADV 7PBZ ALA E 388 UNP P28472 LINKER SEQADV 7PBZ LEU E 389 UNP P28472 LINKER SEQADV 7PBZ LYS E 390 UNP P28472 LINKER SEQADV 7PBZ LEU E 391 UNP P28472 LINKER SEQADV 7PBZ ALA E 392 UNP P28472 LINKER SEQADV 7PBZ ASN E 393 UNP P28472 LINKER SEQADV 7PBZ GLU E 394 UNP P28472 LINKER SEQADV 7PBZ GLY E 395 UNP P28472 LINKER SEQADV 7PBZ LYS E 396 UNP P28472 LINKER SEQADV 7PBZ VAL E 397 UNP P28472 LINKER SEQADV 7PBZ LYS E 398 UNP P28472 LINKER SEQADV 7PBZ GLU E 399 UNP P28472 LINKER SEQADV 7PBZ ALA E 400 UNP P28472 LINKER SEQADV 7PBZ GLN E 401 UNP P28472 LINKER SEQADV 7PBZ ALA E 402 UNP P28472 LINKER SEQADV 7PBZ ALA E 403 UNP P28472 LINKER SEQADV 7PBZ ALA E 404 UNP P28472 LINKER SEQADV 7PBZ GLU E 405 UNP P28472 LINKER SEQADV 7PBZ GLN E 406 UNP P28472 LINKER SEQADV 7PBZ LEU E 407 UNP P28472 LINKER SEQADV 7PBZ LYS E 408 UNP P28472 LINKER SEQADV 7PBZ THR E 409 UNP P28472 LINKER SEQADV 7PBZ THR E 410 UNP P28472 LINKER SEQADV 7PBZ ARG E 411 UNP P28472 LINKER SEQADV 7PBZ ASN E 412 UNP P28472 LINKER SEQADV 7PBZ ALA E 413 UNP P28472 LINKER SEQADV 7PBZ TYR E 414 UNP P28472 LINKER SEQADV 7PBZ ILE E 415 UNP P28472 LINKER SEQADV 7PBZ GLN E 416 UNP P28472 LINKER SEQADV 7PBZ LYS E 417 UNP P28472 LINKER SEQADV 7PBZ TYR E 418 UNP P28472 LINKER SEQADV 7PBZ LEU E 419 UNP P28472 LINKER SEQADV 7PBZ THR E 420 UNP P28472 LINKER SEQADV 7PBZ GLY E 421 UNP P28472 LINKER SEQADV 7PBZ ARG E 422 UNP P28472 LINKER SEQADV 7PBZ ALA E 423 UNP P28472 LINKER SEQADV 7PBZ ALA E 424 UNP P28472 LINKER SEQADV 7PBZ MET D -52 UNP P14867 INITIATING METHIONINE SEQADV 7PBZ ASP D -51 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -50 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LYS D -49 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR D -48 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR D -47 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -46 UNP P14867 EXPRESSION TAG SEQADV 7PBZ TRP D -45 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ARG D -44 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -43 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -42 UNP P14867 EXPRESSION TAG SEQADV 7PBZ HIS D -41 UNP P14867 EXPRESSION TAG SEQADV 7PBZ VAL D -40 UNP P14867 EXPRESSION TAG SEQADV 7PBZ VAL D -39 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -38 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -37 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LEU D -36 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ALA D -35 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -34 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -33 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LEU D -32 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -31 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN D -30 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LEU D -29 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ARG D -28 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ALA D -27 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ARG D -26 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LEU D -25 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -24 UNP P14867 EXPRESSION TAG SEQADV 7PBZ HIS D -23 UNP P14867 EXPRESSION TAG SEQADV 7PBZ HIS D -22 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO D -21 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN D -20 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -19 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN D -18 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ARG D -17 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -16 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO D -15 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ASP D -14 UNP P14867 EXPRESSION TAG SEQADV 7PBZ TYR D -13 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ASP D -12 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ILE D -11 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO D -10 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR D -9 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR D -8 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLU D -7 UNP P14867 EXPRESSION TAG SEQADV 7PBZ ASN D -6 UNP P14867 EXPRESSION TAG SEQADV 7PBZ LEU D -5 UNP P14867 EXPRESSION TAG SEQADV 7PBZ TYR D -4 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PHE D -3 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN D -2 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D -1 UNP P14867 EXPRESSION TAG SEQADV 7PBZ THR D 0 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLY D 1 UNP P14867 EXPRESSION TAG SEQADV 7PBZ GLN D 2 UNP P14867 EXPRESSION TAG SEQADV 7PBZ PRO D 3 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER D 4 UNP P14867 EXPRESSION TAG SEQADV 7PBZ SER D 313 UNP P14867 LINKER SEQADV 7PBZ GLN D 314 UNP P14867 LINKER SEQADV 7PBZ PRO D 315 UNP P14867 LINKER SEQADV 7PBZ ALA D 316 UNP P14867 LINKER SEQADV 7PBZ ARG D 317 UNP P14867 LINKER SEQADV 7PBZ ALA D 318 UNP P14867 LINKER SEQADV 7PBZ ALA D 319 UNP P14867 LINKER SEQRES 1 F 522 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 522 THR LYS THR THR THR SER VAL ILE ASP THR THR ASN ASP SEQRES 3 F 522 ALA GLN ASN LEU LEU THR GLN ALA GLN THR ILE VAL ASN SEQRES 4 F 522 THR LEU LYS ASP TYR CYS PRO ILE LEU ILE ALA LYS SER SEQRES 5 F 522 SER SER SER ASN GLY GLY THR ASN ASN ALA ASN THR PRO SEQRES 6 F 522 SER TRP GLN THR ALA GLY GLY GLY LYS ASN SER CYS ALA SEQRES 7 F 522 THR PHE GLY ALA GLU PHE SER ALA ALA SER ASP MET ILE SEQRES 8 F 522 ASN ASN ALA GLN LYS ILE VAL GLN GLU THR GLN GLN LEU SEQRES 9 F 522 SER ALA ASN GLN PRO LYS ASN ILE THR GLN PRO HIS ASN SEQRES 10 F 522 LEU ASN LEU ASN SER PRO SER SER LEU THR ALA LEU ALA SEQRES 11 F 522 GLN LYS MET LEU LYS ASN ALA GLN SER GLN ALA GLU ILE SEQRES 12 F 522 LEU LYS LEU ALA ASN GLN VAL GLU SER ASP PHE ASN LYS SEQRES 13 F 522 LEU SER SER GLY HIS LEU LYS ASP TYR ILE GLY LYS CYS SEQRES 14 F 522 ASP ALA SER ALA ILE SER SER ALA ASN MET THR MET GLN SEQRES 15 F 522 ASN GLN LYS ASN ASN TRP GLY ASN GLY CYS ALA GLY VAL SEQRES 16 F 522 GLU GLU THR GLN SER LEU LEU LYS THR SER ALA ALA ASP SEQRES 17 F 522 PHE ASN ASN GLN THR PRO GLN ILE ASN GLN ALA GLN ASN SEQRES 18 F 522 LEU ALA ASN THR LEU ILE GLN GLU LEU GLY ASN ASN THR SEQRES 19 F 522 TYR GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY SEQRES 20 F 522 THR ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA SEQRES 21 F 522 VAL ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY SEQRES 22 F 522 GLY THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU SEQRES 23 F 522 ALA LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY SEQRES 24 F 522 TYR ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY SEQRES 25 F 522 GLU ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN SEQRES 26 F 522 GLY ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SEQRES 27 F 522 SER ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU SEQRES 28 F 522 LYS ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR SEQRES 29 F 522 GLU LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA SEQRES 30 F 522 LEU LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY SEQRES 31 F 522 GLU LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SEQRES 32 F 522 SER LEU ARG LEU SER CYS ALA ALA SER GLY HIS THR PHE SEQRES 33 F 522 ASN TYR PRO ILE MET GLY TRP PHE ARG GLN ALA PRO GLY SEQRES 34 F 522 LYS GLU ARG GLU PHE VAL GLY ALA ILE SER TRP SER GLY SEQRES 35 F 522 GLY SER THR SER TYR ALA ASP SER VAL LYS ASP ARG PHE SEQRES 36 F 522 THR ILE SER ARG ASP ASN ALA LYS ASN THR VAL TYR LEU SEQRES 37 F 522 GLU MET ASN ASN LEU LYS PRO GLU ASP THR ALA VAL TYR SEQRES 38 F 522 TYR CYS ALA ALA LYS GLY ARG TYR SER GLY GLY LEU TYR SEQRES 39 F 522 TYR PRO THR ASN TYR ASP TYR TRP GLY GLN GLY THR GLN SEQRES 40 F 522 VAL THR VAL SER SER HIS HIS HIS HIS HIS HIS GLU PRO SEQRES 41 F 522 GLU ALA SEQRES 1 A 368 GLN PRO SER GLN ASP GLU LEU LYS ASP ASN THR THR VAL SEQRES 2 A 368 PHE THR ARG ILE LEU ASP ARG LEU LEU ASP GLY TYR ASP SEQRES 3 A 368 ASN ARG LEU ARG PRO GLY LEU GLY GLU ARG VAL THR GLU SEQRES 4 A 368 VAL LYS THR ASP ILE PHE VAL THR SER PHE GLY PRO VAL SEQRES 5 A 368 SER ASP HIS ASP MET GLU TYR THR ILE ASP VAL PHE PHE SEQRES 6 A 368 ARG GLN SER TRP LYS ASP GLU ARG LEU LYS PHE LYS GLY SEQRES 7 A 368 PRO MET THR VAL LEU ARG LEU ASN ASN LEU MET ALA SER SEQRES 8 A 368 LYS ILE TRP THR PRO ASP THR PHE PHE HIS ASN GLY LYS SEQRES 9 A 368 LYS SER VAL ALA HIS ASN MET THR MET PRO ASN LYS LEU SEQRES 10 A 368 LEU ARG ILE THR GLU ASP GLY THR LEU LEU TYR THR MET SEQRES 11 A 368 ARG LEU THR VAL ARG ALA GLU CYS PRO MET HIS LEU GLU SEQRES 12 A 368 ASP PHE PRO MET ASP ALA HIS ALA CYS PRO LEU LYS PHE SEQRES 13 A 368 GLY SER TYR ALA TYR THR ARG ALA GLU VAL VAL TYR GLU SEQRES 14 A 368 TRP THR ARG GLU PRO ALA ARG SER VAL VAL VAL ALA GLU SEQRES 15 A 368 ASP GLY SER ARG LEU ASN GLN TYR ASP LEU LEU GLY GLN SEQRES 16 A 368 THR VAL ASP SER GLY ILE VAL GLN SER SER THR GLY GLU SEQRES 17 A 368 TYR VAL VAL MET THR THR HIS PHE HIS LEU LYS ARG LYS SEQRES 18 A 368 ILE GLY TYR PHE VAL ILE GLN THR TYR LEU PRO CYS ILE SEQRES 19 A 368 MET THR VAL ILE LEU SER GLN VAL SER PHE TRP LEU ASN SEQRES 20 A 368 ARG GLU SER VAL PRO ALA ARG THR VAL PHE GLY VAL THR SEQRES 21 A 368 THR VAL LEU THR MET THR THR LEU SER ILE SER ALA ARG SEQRES 22 A 368 ASN SER LEU PRO LYS VAL ALA TYR ALA THR ALA MET ASP SEQRES 23 A 368 TRP PHE ILE ALA VAL CYS TYR ALA PHE VAL PHE SER ALA SEQRES 24 A 368 LEU ILE GLU PHE ALA THR VAL ASN TYR PHE THR LYS SER SEQRES 25 A 368 GLN PRO ALA ARG ALA ALA LYS ILE ASP ARG LEU SER ARG SEQRES 26 A 368 ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE ASN LEU VAL SEQRES 27 A 368 TYR TRP ALA THR TYR LEU ASN ARG GLU PRO GLN LEU LYS SEQRES 28 A 368 ALA PRO THR PRO HIS GLN GLY THR THR GLU SER THR GLN SEQRES 29 A 368 VAL ALA PRO ALA SEQRES 1 B 451 GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE VAL LYS SEQRES 2 B 451 GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP ILE ARG SEQRES 3 B 451 LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS VAL GLY SEQRES 4 B 451 MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SER GLU SEQRES 5 B 451 VAL ASN MET ASP TYR THR LEU THR MET TYR PHE GLN GLN SEQRES 6 B 451 TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY ILE PRO SEQRES 7 B 451 LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP GLN LEU SEQRES 8 B 451 TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS LYS SER SEQRES 9 B 451 PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET ILE ARG SEQRES 10 B 451 LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU ARG ILE SEQRES 11 B 451 THR THR THR ALA ALA CYS MET MET ASP LEU ARG ARG TYR SEQRES 12 B 451 PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE GLU SER SEQRES 13 B 451 TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR TRP ARG SEQRES 14 B 451 GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG ILE GLU SEQRES 15 B 451 LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU VAL SER SEQRES 16 B 451 ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO ARG LEU SEQRES 17 B 451 SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY TYR PHE SEQRES 18 B 451 ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE THR ILE SEQRES 19 B 451 LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP ALA SER SEQRES 20 B 451 ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL LEU THR SEQRES 21 B 451 MET THR THR ILE ASN THR HIS LEU ARG GLU THR LEU PRO SEQRES 22 B 451 LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR LEU MET SEQRES 23 B 451 GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU GLU TYR SEQRES 24 B 451 ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO ALA GLY SEQRES 25 B 451 THR ALA ASP LEU GLU ASP ASN TRP GLU THR LEU ASN ASP SEQRES 26 B 451 ASN LEU LYS VAL ILE GLU LYS ALA ASP ASN ALA ALA GLN SEQRES 27 B 451 VAL LYS ASP ALA LEU THR LYS MET ARG ALA ALA ALA LEU SEQRES 28 B 451 ASP ALA GLN LYS ALA THR PRO PRO LYS LEU GLU ASP LYS SEQRES 29 B 451 SER PRO ASP SER PRO GLU MET LYS ASP PHE ARG HIS GLY SEQRES 30 B 451 PHE ASP ILE LEU VAL GLY GLN ILE ASP ASP ALA LEU LYS SEQRES 31 B 451 LEU ALA ASN GLU GLY LYS VAL LYS GLU ALA GLN ALA ALA SEQRES 32 B 451 ALA GLU GLN LEU LYS THR THR ARG ASN ALA TYR ILE GLN SEQRES 33 B 451 LYS TYR LEU THR GLY ARG ALA ALA ALA ILE ASP ARG TRP SEQRES 34 B 451 SER ARG ILE VAL PHE PRO PHE THR PHE SER LEU PHE ASN SEQRES 35 B 451 LEU VAL TYR TRP LEU TYR TYR VAL ASN SEQRES 1 C 451 GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE VAL LYS SEQRES 2 C 451 GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP ILE ARG SEQRES 3 C 451 LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS VAL GLY SEQRES 4 C 451 MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SER GLU SEQRES 5 C 451 VAL ASN MET ASP TYR THR LEU THR MET TYR PHE GLN GLN SEQRES 6 C 451 TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY ILE PRO SEQRES 7 C 451 LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP GLN LEU SEQRES 8 C 451 TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS LYS SER SEQRES 9 C 451 PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET ILE ARG SEQRES 10 C 451 LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU ARG ILE SEQRES 11 C 451 THR THR THR ALA ALA CYS MET MET ASP LEU ARG ARG TYR SEQRES 12 C 451 PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE GLU SER SEQRES 13 C 451 TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR TRP ARG SEQRES 14 C 451 GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG ILE GLU SEQRES 15 C 451 LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU VAL SER SEQRES 16 C 451 ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO ARG LEU SEQRES 17 C 451 SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY TYR PHE SEQRES 18 C 451 ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE THR ILE SEQRES 19 C 451 LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP ALA SER SEQRES 20 C 451 ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL LEU THR SEQRES 21 C 451 MET THR THR ILE ASN THR HIS LEU ARG GLU THR LEU PRO SEQRES 22 C 451 LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR LEU MET SEQRES 23 C 451 GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU GLU TYR SEQRES 24 C 451 ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO ALA GLY SEQRES 25 C 451 THR ALA ASP LEU GLU ASP ASN TRP GLU THR LEU ASN ASP SEQRES 26 C 451 ASN LEU LYS VAL ILE GLU LYS ALA ASP ASN ALA ALA GLN SEQRES 27 C 451 VAL LYS ASP ALA LEU THR LYS MET ARG ALA ALA ALA LEU SEQRES 28 C 451 ASP ALA GLN LYS ALA THR PRO PRO LYS LEU GLU ASP LYS SEQRES 29 C 451 SER PRO ASP SER PRO GLU MET LYS ASP PHE ARG HIS GLY SEQRES 30 C 451 PHE ASP ILE LEU VAL GLY GLN ILE ASP ASP ALA LEU LYS SEQRES 31 C 451 LEU ALA ASN GLU GLY LYS VAL LYS GLU ALA GLN ALA ALA SEQRES 32 C 451 ALA GLU GLN LEU LYS THR THR ARG ASN ALA TYR ILE GLN SEQRES 33 C 451 LYS TYR LEU THR GLY ARG ALA ALA ALA ILE ASP ARG TRP SEQRES 34 C 451 SER ARG ILE VAL PHE PRO PHE THR PHE SER LEU PHE ASN SEQRES 35 C 451 LEU VAL TYR TRP LEU TYR TYR VAL ASN SEQRES 1 E 451 GLN SER VAL ASN ASP PRO GLY ASN MET SER PHE VAL LYS SEQRES 2 E 451 GLU THR VAL ASP LYS LEU LEU LYS GLY TYR ASP ILE ARG SEQRES 3 E 451 LEU ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS VAL GLY SEQRES 4 E 451 MET ASN ILE ASP ILE ALA SER ILE ASP MET VAL SER GLU SEQRES 5 E 451 VAL ASN MET ASP TYR THR LEU THR MET TYR PHE GLN GLN SEQRES 6 E 451 TYR TRP ARG ASP LYS ARG LEU ALA TYR SER GLY ILE PRO SEQRES 7 E 451 LEU ASN LEU THR LEU ASP ASN ARG VAL ALA ASP GLN LEU SEQRES 8 E 451 TRP VAL PRO ASP THR TYR PHE LEU ASN ASP LYS LYS SER SEQRES 9 E 451 PHE VAL HIS GLY VAL THR VAL LYS ASN ARG MET ILE ARG SEQRES 10 E 451 LEU HIS PRO ASP GLY THR VAL LEU TYR GLY LEU ARG ILE SEQRES 11 E 451 THR THR THR ALA ALA CYS MET MET ASP LEU ARG ARG TYR SEQRES 12 E 451 PRO LEU ASP GLU GLN ASN CYS THR LEU GLU ILE GLU SER SEQRES 13 E 451 TYR GLY TYR THR THR ASP ASP ILE GLU PHE TYR TRP ARG SEQRES 14 E 451 GLY GLY ASP LYS ALA VAL THR GLY VAL GLU ARG ILE GLU SEQRES 15 E 451 LEU PRO GLN PHE SER ILE VAL GLU HIS ARG LEU VAL SER SEQRES 16 E 451 ARG ASN VAL VAL PHE ALA THR GLY ALA TYR PRO ARG LEU SEQRES 17 E 451 SER LEU SER PHE ARG LEU LYS ARG ASN ILE GLY TYR PHE SEQRES 18 E 451 ILE LEU GLN THR TYR MET PRO SER ILE LEU ILE THR ILE SEQRES 19 E 451 LEU SER TRP VAL SER PHE TRP ILE ASN TYR ASP ALA SER SEQRES 20 E 451 ALA ALA ARG VAL ALA LEU GLY ILE THR THR VAL LEU THR SEQRES 21 E 451 MET THR THR ILE ASN THR HIS LEU ARG GLU THR LEU PRO SEQRES 22 E 451 LYS ILE PRO TYR VAL LYS ALA ILE ASP MET TYR LEU MET SEQRES 23 E 451 GLY CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU GLU TYR SEQRES 24 E 451 ALA PHE VAL ASN TYR ILE PHE PHE SER GLN PRO ALA GLY SEQRES 25 E 451 THR ALA ASP LEU GLU ASP ASN TRP GLU THR LEU ASN ASP SEQRES 26 E 451 ASN LEU LYS VAL ILE GLU LYS ALA ASP ASN ALA ALA GLN SEQRES 27 E 451 VAL LYS ASP ALA LEU THR LYS MET ARG ALA ALA ALA LEU SEQRES 28 E 451 ASP ALA GLN LYS ALA THR PRO PRO LYS LEU GLU ASP LYS SEQRES 29 E 451 SER PRO ASP SER PRO GLU MET LYS ASP PHE ARG HIS GLY SEQRES 30 E 451 PHE ASP ILE LEU VAL GLY GLN ILE ASP ASP ALA LEU LYS SEQRES 31 E 451 LEU ALA ASN GLU GLY LYS VAL LYS GLU ALA GLN ALA ALA SEQRES 32 E 451 ALA GLU GLN LEU LYS THR THR ARG ASN ALA TYR ILE GLN SEQRES 33 E 451 LYS TYR LEU THR GLY ARG ALA ALA ALA ILE ASP ARG TRP SEQRES 34 E 451 SER ARG ILE VAL PHE PRO PHE THR PHE SER LEU PHE ASN SEQRES 35 E 451 LEU VAL TYR TRP LEU TYR TYR VAL ASN SEQRES 1 D 411 MET ASP GLU LYS THR THR GLY TRP ARG GLY GLY HIS VAL SEQRES 2 D 411 VAL GLU GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA SEQRES 3 D 411 ARG LEU GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ASP SEQRES 4 D 411 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY SEQRES 5 D 411 THR GLY GLN PRO SER GLN ASP GLU LEU LYS ASP ASN THR SEQRES 6 D 411 THR VAL PHE THR ARG ILE LEU ASP ARG LEU LEU ASP GLY SEQRES 7 D 411 TYR ASP ASN ARG LEU ARG PRO GLY LEU GLY GLU ARG VAL SEQRES 8 D 411 THR GLU VAL LYS THR ASP ILE PHE VAL THR SER PHE GLY SEQRES 9 D 411 PRO VAL SER ASP HIS ASP MET GLU TYR THR ILE ASP VAL SEQRES 10 D 411 PHE PHE ARG GLN SER TRP LYS ASP GLU ARG LEU LYS PHE SEQRES 11 D 411 LYS GLY PRO MET THR VAL LEU ARG LEU ASN ASN LEU MET SEQRES 12 D 411 ALA SER LYS ILE TRP THR PRO ASP THR PHE PHE HIS ASN SEQRES 13 D 411 GLY LYS LYS SER VAL ALA HIS ASN MET THR MET PRO ASN SEQRES 14 D 411 LYS LEU LEU ARG ILE THR GLU ASP GLY THR LEU LEU TYR SEQRES 15 D 411 THR MET ARG LEU THR VAL ARG ALA GLU CYS PRO MET HIS SEQRES 16 D 411 LEU GLU ASP PHE PRO MET ASP ALA HIS ALA CYS PRO LEU SEQRES 17 D 411 LYS PHE GLY SER TYR ALA TYR THR ARG ALA GLU VAL VAL SEQRES 18 D 411 TYR GLU TRP THR ARG GLU PRO ALA ARG SER VAL VAL VAL SEQRES 19 D 411 ALA GLU ASP GLY SER ARG LEU ASN GLN TYR ASP LEU LEU SEQRES 20 D 411 GLY GLN THR VAL ASP SER GLY ILE VAL GLN SER SER THR SEQRES 21 D 411 GLY GLU TYR VAL VAL MET THR THR HIS PHE HIS LEU LYS SEQRES 22 D 411 ARG LYS ILE GLY TYR PHE VAL ILE GLN THR TYR LEU PRO SEQRES 23 D 411 CYS ILE MET THR VAL ILE LEU SER GLN VAL SER PHE TRP SEQRES 24 D 411 LEU ASN ARG GLU SER VAL PRO ALA ARG THR VAL PHE GLY SEQRES 25 D 411 VAL THR THR VAL LEU THR MET THR THR LEU SER ILE SER SEQRES 26 D 411 ALA ARG ASN SER LEU PRO LYS VAL ALA TYR ALA THR ALA SEQRES 27 D 411 MET ASP TRP PHE ILE ALA VAL CYS TYR ALA PHE VAL PHE SEQRES 28 D 411 SER ALA LEU ILE GLU PHE ALA THR VAL ASN TYR PHE THR SEQRES 29 D 411 LYS SER GLN PRO ALA ARG ALA ALA LYS ILE ASP ARG LEU SEQRES 30 D 411 SER ARG ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE ASN SEQRES 31 D 411 LEU VAL TYR TRP ALA THR TYR LEU ASN ARG GLU PRO GLN SEQRES 32 D 411 LEU LYS ALA PRO THR PRO HIS GLN HET NAG A 501 14 HET UND A 502 11 HET OCT A 503 8 HET UND A 504 11 HET OCT A 505 8 HET HEX A 506 6 HET ABU B 501 7 HET HEX B 502 6 HET ZN B 503 1 HET HSM C 601 8 HET D10 C 602 10 HET ABU E 501 7 HET NAG D 501 14 HET HEX D 502 6 HET HEX D 503 6 HET D10 D 504 10 HET D10 D 505 10 HET NAG G 1 14 HET NAG G 2 14 HET NAG H 1 14 HET NAG H 2 14 HET BMA H 3 11 HET MAN H 4 11 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET BMA J 3 11 HET MAN J 4 11 HET MAN J 5 11 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HET BMA L 3 11 HET MAN L 4 11 HET MAN L 5 11 HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM UND UNDECANE HETNAM OCT N-OCTANE HETNAM HEX HEXANE HETNAM ABU GAMMA-AMINO-BUTANOIC ACID HETNAM ZN ZINC ION HETNAM HSM HISTAMINE HETNAM D10 DECANE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE HETSYN UND LIPID FRAGMENT HETSYN ABU GAMMA(AMINO)-BUTYRIC ACID FORMUL 7 NAG 14(C8 H15 N O6) FORMUL 8 UND 2(C11 H24) FORMUL 9 OCT 2(C8 H18) FORMUL 12 HEX 4(C6 H14) FORMUL 13 ABU 2(C4 H9 N O2) FORMUL 15 ZN ZN 2+ FORMUL 16 HSM C5 H9 N3 FORMUL 17 D10 3(C10 H22) FORMUL 25 BMA 3(C6 H12 O6) FORMUL 25 MAN 5(C6 H12 O6) HELIX 1 AA1 LYS F 474 THR F 478 5 5 HELIX 2 AA2 TYR F 495 TYR F 499 5 5 HELIX 3 AA3 THR A 13 LEU A 23 1 11 HELIX 4 AA4 GLU A 73 LYS A 76 5 4 HELIX 5 AA5 ASN A 87 ILE A 94 5 8 HELIX 6 AA6 GLU A 174 VAL A 179 1 6 HELIX 7 AA7 ILE A 223 THR A 230 1 8 HELIX 8 AA8 THR A 230 SER A 244 1 15 HELIX 9 AA9 SER A 251 LEU A 277 1 27 HELIX 10 AB1 THR A 284 PHE A 310 1 27 HELIX 11 AB2 GLN A 314 TYR A 415 1 31 HELIX 12 AB3 MET B 9 LEU B 20 1 12 HELIX 13 AB4 LYS B 70 ALA B 73 5 4 HELIX 14 AB5 ASP B 84 LEU B 91 5 8 HELIX 15 AB6 ASP B 139 TYR B 143 5 5 HELIX 16 AB7 GLY B 170 LYS B 173 5 4 HELIX 17 AB8 GLY B 177 ILE B 181 5 5 HELIX 18 AB9 ILE B 218 THR B 225 1 8 HELIX 19 AC1 THR B 225 ASN B 243 1 19 HELIX 20 AC2 ALA B 246 GLU B 270 1 25 HELIX 21 AC3 LYS B 279 SER B 308 1 30 HELIX 22 AC4 ALA B 420 ILE B 429 1 10 HELIX 23 AC5 VAL B 430 TYR B 446 1 17 HELIX 24 AC6 MET C 9 LYS C 21 1 13 HELIX 25 AC7 LYS C 70 ALA C 73 5 4 HELIX 26 AC8 ASP C 84 LEU C 91 5 8 HELIX 27 AC9 ASP C 139 TYR C 143 5 5 HELIX 28 AD1 GLY C 170 LYS C 173 5 4 HELIX 29 AD2 TYR C 220 THR C 225 1 6 HELIX 30 AD3 THR C 225 ILE C 242 1 18 HELIX 31 AD4 ALA C 246 THR C 271 1 26 HELIX 32 AD5 LYS C 279 SER C 308 1 30 HELIX 33 AD6 ALA C 420 TYR C 446 1 27 HELIX 34 AD7 MET E 9 LYS E 21 1 13 HELIX 35 AD8 LYS E 70 ALA E 73 5 4 HELIX 36 AD9 ASP E 84 GLN E 90 5 7 HELIX 37 AE1 ASP E 139 TYR E 143 5 5 HELIX 38 AE2 GLY E 170 LYS E 173 5 4 HELIX 39 AE3 ILE E 218 THR E 225 1 8 HELIX 40 AE4 THR E 225 TRP E 237 1 13 HELIX 41 AE5 VAL E 238 ILE E 242 5 5 HELIX 42 AE6 ALA E 246 LEU E 272 1 27 HELIX 43 AE7 LYS E 279 SER E 308 1 30 HELIX 44 AE8 ALA E 423 TYR E 449 1 27 HELIX 45 AE9 THR D 13 LEU D 23 1 11 HELIX 46 AF1 GLU D 73 LYS D 76 5 4 HELIX 47 AF2 ASN D 88 LYS D 93 1 6 HELIX 48 AF3 PRO D 175 ARG D 177 5 3 HELIX 49 AF4 ILE D 223 THR D 230 1 8 HELIX 50 AF5 THR D 230 SER D 244 1 15 HELIX 51 AF6 PHE D 245 LEU D 247 5 3 HELIX 52 AF7 SER D 251 LEU D 277 1 27 HELIX 53 AF8 THR D 284 PHE D 310 1 27 HELIX 54 AF9 GLN D 314 ASN D 417 1 33 SHEET 1 AA1 4 VAL F 2 SER F 7 0 SHEET 2 AA1 4 ARG F 406 GLY F 413 -1 O ALA F 410 N GLN F 5 SHEET 3 AA1 4 THR F 465 MET F 470 -1 O VAL F 466 N CYS F 409 SHEET 4 AA1 4 PHE F 455 ASP F 460 -1 N ASP F 460 O THR F 465 SHEET 1 AA2 6 ILE F 420 GLN F 426 0 SHEET 2 AA2 6 GLU F 433 SER F 439 -1 O GLU F 433 N ARG F 425 SHEET 3 AA2 6 THR F 445 TYR F 447 -1 O SER F 446 N ALA F 437 SHEET 4 AA2 6 ALA F 479 LYS F 486 -1 O VAL F 480 N GLN F 426 SHEET 5 AA2 6 TYR F 501 TRP F 502 -1 O TYR F 501 N ALA F 485 SHEET 6 AA2 6 THR F 506 VAL F 508 -1 O VAL F 508 N ALA F 479 SHEET 1 AA3 8 THR A 39 SER A 54 0 SHEET 2 AA3 8 GLU A 59 LYS A 71 -1 O ARG A 67 N ASP A 44 SHEET 3 AA3 8 VAL A 83 LEU A 86 0 SHEET 4 AA3 8 VAL A 108 ALA A 109 0 SHEET 5 AA3 8 LYS A 117 THR A 122 -1 O ILE A 121 N LEU A 84 SHEET 6 AA3 8 THR A 126 GLU A 138 -1 O LEU A 128 N ARG A 120 SHEET 7 AA3 8 VAL A 167 TRP A 171 1 O GLU A 170 N THR A 43 SHEET 8 AA3 8 VAL A 180 VAL A 181 1 O VAL A 180 N VAL A 47 SHEET 1 AA4 4 THR A 99 PHE A 101 0 SHEET 2 AA4 4 ALA A 150 SER A 159 -1 O GLY A 158 N PHE A 100 SHEET 3 AA4 4 TYR A 210 ARG A 221 -1 O MET A 213 N PHE A 157 SHEET 4 AA4 4 TYR A 191 VAL A 203 -1 N ASP A 199 O THR A 214 SHEET 1 AA5 8 VAL B 36 SER B 51 0 SHEET 2 AA5 8 ASP B 56 ARG B 68 -1 O TYR B 66 N GLY B 39 SHEET 3 AA5 8 LEU B 81 LEU B 83 0 SHEET 4 AA5 8 ASP B 101 VAL B 106 0 SHEET 5 AA5 8 ARG B 114 LEU B 118 -1 O LEU B 118 N LEU B 81 SHEET 6 AA5 8 THR B 123 ALA B 135 -1 O LEU B 125 N ARG B 117 SHEET 7 AA5 8 ILE B 164 TRP B 168 1 O GLU B 165 N VAL B 38 SHEET 8 AA5 8 VAL B 175 THR B 176 1 O THR B 176 N ILE B 44 SHEET 1 AA6 4 THR B 96 PHE B 98 0 SHEET 2 AA6 4 GLU B 147 SER B 156 -1 O GLU B 155 N TYR B 97 SHEET 3 AA6 4 ALA B 204 ARG B 216 -1 O LEU B 208 N ILE B 154 SHEET 4 AA6 4 PHE B 186 VAL B 199 -1 N VAL B 198 O TYR B 205 SHEET 1 AA7 9 VAL C 36 SER C 46 0 SHEET 2 AA7 9 VAL C 50 SER C 51 0 SHEET 3 AA7 9 ASP C 56 ARG C 68 -1 O ASP C 56 N SER C 51 SHEET 4 AA7 9 THR C 82 LEU C 83 0 SHEET 5 AA7 9 ASP C 101 VAL C 106 0 SHEET 6 AA7 9 ARG C 114 LEU C 118 -1 O ILE C 116 N LEU C 83 SHEET 7 AA7 9 THR C 123 ALA C 135 -1 O LEU C 125 N ARG C 117 SHEET 8 AA7 9 ILE C 164 TRP C 168 1 O GLU C 165 N VAL C 38 SHEET 9 AA7 9 VAL C 175 THR C 176 1 O THR C 176 N ILE C 44 SHEET 1 AA8 4 THR C 96 PHE C 98 0 SHEET 2 AA8 4 GLU C 147 SER C 156 -1 O GLU C 155 N TYR C 97 SHEET 3 AA8 4 ALA C 204 ARG C 216 -1 O LEU C 208 N ILE C 154 SHEET 4 AA8 4 PHE C 186 VAL C 199 -1 N VAL C 198 O TYR C 205 SHEET 1 AA9 8 VAL E 36 SER E 51 0 SHEET 2 AA9 8 ASP E 56 ARG E 68 -1 O GLN E 64 N ASN E 41 SHEET 3 AA9 8 LEU E 81 LEU E 83 0 SHEET 4 AA9 8 ASP E 101 VAL E 106 0 SHEET 5 AA9 8 ARG E 114 LEU E 118 -1 O LEU E 118 N LEU E 81 SHEET 6 AA9 8 THR E 123 ALA E 135 -1 O GLY E 127 N MET E 115 SHEET 7 AA9 8 ILE E 164 TRP E 168 1 O GLU E 165 N VAL E 38 SHEET 8 AA9 8 VAL E 175 THR E 176 1 O THR E 176 N ILE E 44 SHEET 1 AB1 4 THR E 96 PHE E 98 0 SHEET 2 AB1 4 GLU E 147 SER E 156 -1 O GLU E 155 N TYR E 97 SHEET 3 AB1 4 ALA E 204 ARG E 216 -1 O LEU E 210 N LEU E 152 SHEET 4 AB1 4 PHE E 186 VAL E 199 -1 N VAL E 189 O ARG E 213 SHEET 1 AB2 9 THR D 39 SER D 49 0 SHEET 2 AB2 9 VAL D 53 SER D 54 0 SHEET 3 AB2 9 GLU D 59 LYS D 71 -1 O GLU D 59 N SER D 54 SHEET 4 AB2 9 VAL D 83 LEU D 86 0 SHEET 5 AB2 9 GLY D 104 ALA D 109 0 SHEET 6 AB2 9 LYS D 117 THR D 122 -1 O ILE D 121 N LEU D 84 SHEET 7 AB2 9 THR D 126 GLU D 138 -1 O THR D 126 N THR D 122 SHEET 8 AB2 9 VAL D 167 TRP D 171 1 O GLU D 170 N THR D 43 SHEET 9 AB2 9 VAL D 179 VAL D 181 1 O VAL D 180 N ILE D 45 SHEET 1 AB3 4 THR D 99 PHE D 101 0 SHEET 2 AB3 4 ALA D 150 SER D 159 -1 O GLY D 158 N PHE D 100 SHEET 3 AB3 4 GLU D 209 ARG D 221 -1 O MET D 213 N PHE D 157 SHEET 4 AB3 4 TYR D 191 GLN D 204 -1 N LEU D 194 O HIS D 218 SSBOND 1 CYS F 409 CYS F 483 1555 1555 2.04 SSBOND 2 CYS A 139 CYS A 153 1555 1555 2.03 SSBOND 3 CYS B 136 CYS B 150 1555 1555 2.04 SSBOND 4 CYS C 136 CYS C 150 1555 1555 2.03 SSBOND 5 CYS E 136 CYS E 150 1555 1555 2.03 SSBOND 6 CYS D 139 CYS D 153 1555 1555 2.03 LINK ND2 ASN A 111 C1 NAG A 501 1555 1555 1.70 LINK ND2 ASN B 80 C1 NAG G 1 1555 1555 1.49 LINK ND2 ASN B 149 C1 NAG H 1 1555 1555 1.65 LINK ND2 ASN C 80 C1 NAG I 1 1555 1555 1.65 LINK ND2 ASN C 149 C1 NAG J 1 1555 1555 1.52 LINK ND2 ASN E 80 C1 NAG K 1 1555 1555 1.70 LINK ND2 ASN E 149 C1 NAG L 1 1555 1555 1.51 LINK ND2 ASN D 111 C1 NAG D 501 1555 1555 1.67 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.42 LINK O4 NAG H 2 C1 BMA H 3 1555 1555 1.43 LINK O6 BMA H 3 C1 MAN H 4 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.48 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.45 LINK O4 NAG J 2 C1 BMA J 3 1555 1555 1.44 LINK O3 BMA J 3 C1 MAN J 4 1555 1555 1.43 LINK O6 BMA J 3 C1 MAN J 5 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.49 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.43 LINK O4 NAG L 2 C1 BMA L 3 1555 1555 1.43 LINK O3 BMA L 3 C1 MAN L 4 1555 1555 1.43 LINK O6 BMA L 3 C1 MAN L 5 1555 1555 1.42 LINK NE2 HIS B 267 ZN ZN B 503 1555 1555 2.62 LINK ZN ZN B 503 NE2 HIS C 267 1555 1555 2.47 LINK ZN ZN B 503 NE2 HIS E 267 1555 1555 2.46 CISPEP 1 PHE A 146 PRO A 147 0 -0.59 CISPEP 2 TYR B 143 PRO B 144 0 -1.11 CISPEP 3 TYR C 143 PRO C 144 0 0.40 CISPEP 4 TYR E 143 PRO E 144 0 1.13 CISPEP 5 PHE D 146 PRO D 147 0 -1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000