HEADER VIRAL PROTEIN 07-JAN-22 7QQB TITLE CRYSTAL STRUCTURE OF THE ENVELOPE GLYCOPROTEIN COMPLEX OF PUUMALA TITLE 2 VIRUS IN COMPLEX WITH THE SCFV FRAGMENT OF THE BROADLY NEUTRALIZING TITLE 3 HUMAN ANTIBODY ADI-42898 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE POLYPROTEIN; COMPND 3 CHAIN: A, B; COMPND 4 SYNONYM: M POLYPROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: SINGLE CHAIN VARIABLE FRAGMENT (SCFV) OF ADI-42898; COMPND 8 CHAIN: H, L; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: PUUMALA ORTHOHANTAVIRUS; SOURCE 3 ORGANISM_TAXID: 1980486; SOURCE 4 EXPRESSION_SYSTEM: DROSOPHILA MELANOGASTER; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 7227; SOURCE 6 EXPRESSION_SYSTEM_CELL_LINE: S2 CELLS; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: DROSOPHILA MELANOGASTER; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 7227; SOURCE 12 EXPRESSION_SYSTEM_CELL_LINE: S2 CELLS KEYWDS HANTAVIRUS, NEUTRALIZING ANTIBODIES, FUSION PROTEINS, BUNYAVIRUS, KEYWDS 2 VIRAL PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR A.SERRIS,F.A.REY,P.GUARDADO-CALVO JRNL AUTH E.MITTLER,A.SERRIS,E.S.ESTERMAN,C.FLOREZ,L.C.POLANCO, JRNL AUTH 2 C.M.O'BRIEN,M.M.SLOUGH,J.TYNELL,R.GRONING,Y.SUN,D.M.ABELSON, JRNL AUTH 3 A.Z.WEC,D.HASLWANTER,M.KELLER,C.YE,R.R.BAKKEN,R.K.JANGRA, JRNL AUTH 4 J.M.DYE,C.AHLM,C.G.RAPPAZZO,R.G.ULRICH,L.ZEITLIN, JRNL AUTH 5 J.C.GEOGHEGAN,S.B.BRADFUTE,S.SIDOLI,M.N.E.FORSELL, JRNL AUTH 6 T.STRANDIN,F.A.REY,A.S.HERBERT,L.M.WALKER,K.CHANDRAN, JRNL AUTH 7 P.GUARDADO-CALVO JRNL TITL STRUCTURAL AND MECHANISTIC BASIS OF NEUTRALIZATION BY A JRNL TITL 2 PAN-HANTAVIRUS PROTECTIVE ANTIBODY. JRNL REF SCI TRANSL MED V. 15 G1855 2023 JRNL REFN ESSN 1946-6242 JRNL PMID 37315110 JRNL DOI 10.1126/SCITRANSLMED.ADG1855 REMARK 2 REMARK 2 RESOLUTION. 2.60 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : PHENIX 1.18 REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART REMARK 3 REMARK 3 REFINEMENT TARGET : NULL REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 39.00 REMARK 3 MIN(FOBS/SIGMA_FOBS) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 100.0 REMARK 3 NUMBER OF REFLECTIONS : 43057 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 R VALUE (WORKING + TEST SET) : NULL REMARK 3 R VALUE (WORKING SET) : 0.212 REMARK 3 FREE R VALUE : 0.249 REMARK 3 FREE R VALUE TEST SET SIZE (%) : NULL REMARK 3 FREE R VALUE TEST SET COUNT : NULL REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : NULL REMARK 3 SOLVENT RADIUS : NULL REMARK 3 SHRINKAGE RADIUS : NULL REMARK 3 K_SOL : NULL REMARK 3 B_SOL : NULL REMARK 3 REMARK 3 ERROR ESTIMATES. REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : NULL REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : NULL REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 85.64 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 TWINNING INFORMATION. REMARK 3 FRACTION: NULL REMARK 3 OPERATOR: NULL REMARK 3 REMARK 3 DEVIATIONS FROM IDEAL VALUES. REMARK 3 RMSD COUNT REMARK 3 BOND : NULL NULL REMARK 3 ANGLE : NULL NULL REMARK 3 CHIRALITY : NULL NULL REMARK 3 PLANARITY : NULL NULL REMARK 3 DIHEDRAL : NULL NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 NCS DETAILS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: NULL REMARK 4 REMARK 4 7QQB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE. REMARK 100 THE DEPOSITION ID IS D_1292120101. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 27-JAN-20 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 7.5 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : SOLEIL REMARK 200 BEAMLINE : PROXIMA 1 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.98 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS EIGER X 16M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : AIMLESS 0.7.4 REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 43057 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.600 REMARK 200 RESOLUTION RANGE LOW (A) : 39.890 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 100.0 REMARK 200 DATA REDUNDANCY : 11.50 REMARK 200 R MERGE (I) : 0.12000 REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 14.2000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.70 REMARK 200 COMPLETENESS FOR SHELL (%) : 100.0 REMARK 200 DATA REDUNDANCY IN SHELL : 11.90 REMARK 200 R MERGE FOR SHELL (I) : 2.91200 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : NULL REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: NULL REMARK 200 STARTING MODEL: 6Y5F REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): NULL REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 25%(W/V) PEG 1000, 0.1M HEPES 7.5, PH REMARK 280 7.5, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 2 21 21 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 X,-Y,-Z REMARK 290 3555 -X,Y+1/2,-Z+1/2 REMARK 290 4555 -X,-Y+1/2,Z+1/2 REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 54.65200 REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 74.77000 REMARK 290 SMTRY1 4 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 54.65200 REMARK 290 SMTRY3 4 0.000000 0.000000 1.000000 74.77000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, H, L, C, D, E REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ARG A 18 REMARK 465 SER A 19 REMARK 465 SER A 20 REMARK 465 ARG A 21 REMARK 465 GLY A 22 REMARK 465 ASP A 23 REMARK 465 THR A 24 REMARK 465 ARG A 25 REMARK 465 MET A 200 REMARK 465 ALA A 201 REMARK 465 LEU A 202 REMARK 465 SER A 203 REMARK 465 GLY A 382 REMARK 465 GLY A 383 REMARK 465 SER A 384 REMARK 465 GLY A 385 REMARK 465 LEU A 386 REMARK 465 VAL A 387 REMARK 465 PRO A 388 REMARK 465 ARG A 389 REMARK 465 GLY A 390 REMARK 465 SER A 391 REMARK 465 GLY A 392 REMARK 465 GLY A 393 REMARK 465 GLY A 394 REMARK 465 SER A 395 REMARK 465 GLY A 396 REMARK 465 GLY A 397 REMARK 465 GLY A 398 REMARK 465 SER A 399 REMARK 465 TRP A 400 REMARK 465 SER A 401 REMARK 465 HIS A 402 REMARK 465 PRO A 403 REMARK 465 GLN A 404 REMARK 465 PHE A 405 REMARK 465 GLU A 406 REMARK 465 LYS A 407 REMARK 465 GLY A 408 REMARK 465 GLY A 409 REMARK 465 GLY A 410 REMARK 465 THR A 411 REMARK 465 GLY A 412 REMARK 465 GLY A 413 REMARK 465 GLY A 414 REMARK 465 THR A 415 REMARK 465 LEU A 416 REMARK 465 VAL A 417 REMARK 465 PRO A 418 REMARK 465 ARG A 419 REMARK 465 GLY A 420 REMARK 465 SER A 421 REMARK 465 GLY A 422 REMARK 465 THR A 423 REMARK 465 GLY A 424 REMARK 465 GLY A 425 REMARK 465 GLU A 426 REMARK 465 THR A 427 REMARK 465 GLN A 428 REMARK 465 ASN A 429 REMARK 465 LEU A 430 REMARK 465 ASN A 431 REMARK 465 SER A 432 REMARK 465 GLY A 433 REMARK 465 TRP A 434 REMARK 465 THR A 435 REMARK 465 ASP A 436 REMARK 465 THR A 437 REMARK 465 ALA A 438 REMARK 465 HIS A 439 REMARK 465 GLY A 440 REMARK 465 SER A 441 REMARK 465 GLY A 442 REMARK 465 VAL A 443 REMARK 465 ILE A 444 REMARK 465 PRO A 445 REMARK 465 MET A 446 REMARK 465 ARG A 447 REMARK 465 THR A 448 REMARK 465 ASP A 449 REMARK 465 LEU A 450 REMARK 465 GLU A 451 REMARK 465 LEU A 452 REMARK 465 ASP A 453 REMARK 465 PHE A 454 REMARK 465 SER A 455 REMARK 465 LEU A 456 REMARK 465 PRO A 457 REMARK 465 SER A 458 REMARK 465 SER A 459 REMARK 465 ALA A 460 REMARK 465 SER A 461 REMARK 465 TYR A 462 REMARK 465 THR A 463 REMARK 465 TYR A 464 REMARK 465 ARG A 465 REMARK 465 ARG A 466 REMARK 465 GLN A 467 REMARK 465 LEU A 468 REMARK 465 GLN A 469 REMARK 465 ASN A 470 REMARK 465 PRO A 471 REMARK 465 ALA A 472 REMARK 465 ASN A 473 REMARK 465 GLU A 474 REMARK 465 GLN A 475 REMARK 465 GLU A 476 REMARK 465 LYS A 477 REMARK 465 ILE A 478 REMARK 465 PRO A 479 REMARK 465 PHE A 480 REMARK 465 HIS A 481 REMARK 465 LEU A 482 REMARK 465 GLN A 483 REMARK 465 ILE A 484 REMARK 465 SER A 485 REMARK 465 LYS A 486 REMARK 465 GLN A 487 REMARK 465 VAL A 488 REMARK 465 ILE A 489 REMARK 465 HIS A 490 REMARK 465 ALA A 491 REMARK 465 GLU A 492 REMARK 465 ILE A 493 REMARK 465 GLN A 494 REMARK 465 HIS A 495 REMARK 465 LEU A 496 REMARK 465 GLY A 497 REMARK 465 HIS A 498 REMARK 465 TRP A 499 REMARK 465 MET A 500 REMARK 465 ASP A 501 REMARK 465 GLY A 502 REMARK 465 THR A 503 REMARK 465 PHE A 504 REMARK 465 ASN A 505 REMARK 465 LEU A 506 REMARK 465 LYS A 507 REMARK 465 THR A 508 REMARK 465 ALA A 509 REMARK 465 PHE A 510 REMARK 465 HIS A 511 REMARK 465 CYS A 512 REMARK 465 TYR A 513 REMARK 465 GLY A 514 REMARK 465 SER A 515 REMARK 465 CYS A 516 REMARK 465 GLU A 517 REMARK 465 LYS A 518 REMARK 465 TYR A 519 REMARK 465 ALA A 520 REMARK 465 TYR A 521 REMARK 465 PRO A 522 REMARK 465 TRP A 523 REMARK 465 GLN A 524 REMARK 465 THR A 525 REMARK 465 ALA A 526 REMARK 465 GLY A 527 REMARK 465 CYS A 528 REMARK 465 PHE A 529 REMARK 465 VAL A 530 REMARK 465 GLU A 531 REMARK 465 LYS A 532 REMARK 465 ASP A 533 REMARK 465 TYR A 534 REMARK 465 GLU A 535 REMARK 465 TYR A 536 REMARK 465 GLU A 537 REMARK 465 SER A 538 REMARK 465 GLY A 539 REMARK 465 TRP A 540 REMARK 465 GLY A 541 REMARK 465 CYS A 542 REMARK 465 ASN A 543 REMARK 465 PRO A 544 REMARK 465 ALA A 545 REMARK 465 ASP A 546 REMARK 465 CYS A 547 REMARK 465 PRO A 548 REMARK 465 GLY A 549 REMARK 465 VAL A 550 REMARK 465 GLY A 551 REMARK 465 THR A 552 REMARK 465 GLY A 553 REMARK 465 CYS A 554 REMARK 465 THR A 555 REMARK 465 ALA A 556 REMARK 465 CYS A 557 REMARK 465 GLY A 558 REMARK 465 VAL A 559 REMARK 465 TYR A 560 REMARK 465 LEU A 561 REMARK 465 ASP A 562 REMARK 465 LYS A 563 REMARK 465 LEU A 564 REMARK 465 LYS A 565 REMARK 465 SER A 566 REMARK 465 VAL A 567 REMARK 465 GLY A 568 REMARK 465 LYS A 569 REMARK 465 ALA A 570 REMARK 465 PHE A 571 REMARK 465 LYS A 572 REMARK 465 ILE A 573 REMARK 465 VAL A 574 REMARK 465 SER A 575 REMARK 465 LEU A 576 REMARK 465 ARG A 577 REMARK 465 TYR A 578 REMARK 465 THR A 579 REMARK 465 ARG A 580 REMARK 465 LYS A 581 REMARK 465 ALA A 582 REMARK 465 CYS A 583 REMARK 465 ILE A 584 REMARK 465 GLN A 585 REMARK 465 LEU A 586 REMARK 465 GLY A 587 REMARK 465 THR A 588 REMARK 465 GLU A 589 REMARK 465 GLN A 590 REMARK 465 THR A 591 REMARK 465 CYS A 592 REMARK 465 LYS A 593 REMARK 465 ASN A 594 REMARK 465 VAL A 595 REMARK 465 ASP A 596 REMARK 465 SER A 597 REMARK 465 ASN A 598 REMARK 465 ASP A 599 REMARK 465 CYS A 600 REMARK 465 LEU A 601 REMARK 465 VAL A 602 REMARK 465 THR A 603 REMARK 465 THR A 604 REMARK 465 SER A 605 REMARK 465 VAL A 606 REMARK 465 LYS A 607 REMARK 465 VAL A 608 REMARK 465 CYS A 609 REMARK 465 LEU A 610 REMARK 465 ILE A 611 REMARK 465 GLY A 612 REMARK 465 THR A 613 REMARK 465 VAL A 614 REMARK 465 SER A 615 REMARK 465 LYS A 616 REMARK 465 PHE A 617 REMARK 465 GLN A 618 REMARK 465 PRO A 619 REMARK 465 SER A 620 REMARK 465 ASP A 621 REMARK 465 THR A 622 REMARK 465 LEU A 623 REMARK 465 LEU A 624 REMARK 465 PHE A 625 REMARK 465 LEU A 626 REMARK 465 GLY A 627 REMARK 465 PRO A 628 REMARK 465 LEU A 629 REMARK 465 GLU A 630 REMARK 465 GLN A 631 REMARK 465 GLY A 632 REMARK 465 GLY A 633 REMARK 465 LEU A 634 REMARK 465 ILE A 635 REMARK 465 PHE A 636 REMARK 465 LYS A 637 REMARK 465 GLN A 638 REMARK 465 TRP A 639 REMARK 465 CYS A 640 REMARK 465 THR A 641 REMARK 465 THR A 642 REMARK 465 THR A 643 REMARK 465 CYS A 644 REMARK 465 GLN A 645 REMARK 465 PHE A 646 REMARK 465 GLY A 647 REMARK 465 ASP A 648 REMARK 465 PRO A 649 REMARK 465 GLY A 650 REMARK 465 ASP A 651 REMARK 465 ILE A 652 REMARK 465 MET A 653 REMARK 465 SER A 654 REMARK 465 THR A 655 REMARK 465 PRO A 656 REMARK 465 VAL A 657 REMARK 465 GLY A 658 REMARK 465 MET A 659 REMARK 465 LYS A 660 REMARK 465 CYS A 661 REMARK 465 PRO A 662 REMARK 465 GLU A 663 REMARK 465 LEU A 664 REMARK 465 SER A 665 REMARK 465 GLY A 666 REMARK 465 SER A 667 REMARK 465 PHE A 668 REMARK 465 ARG A 669 REMARK 465 LYS A 670 REMARK 465 LYS A 671 REMARK 465 CYS A 672 REMARK 465 ALA A 673 REMARK 465 PHE A 674 REMARK 465 ALA A 675 REMARK 465 THR A 676 REMARK 465 THR A 677 REMARK 465 PRO A 678 REMARK 465 VAL A 679 REMARK 465 CYS A 680 REMARK 465 GLN A 681 REMARK 465 PHE A 682 REMARK 465 ASP A 683 REMARK 465 GLY A 684 REMARK 465 ASN A 685 REMARK 465 THR A 686 REMARK 465 ILE A 687 REMARK 465 SER A 688 REMARK 465 GLY A 689 REMARK 465 TYR A 690 REMARK 465 LYS A 691 REMARK 465 ARG A 692 REMARK 465 MET A 693 REMARK 465 ILE A 694 REMARK 465 ALA A 695 REMARK 465 THR A 696 REMARK 465 LYS A 697 REMARK 465 ASP A 698 REMARK 465 SER A 699 REMARK 465 PHE A 700 REMARK 465 GLN A 701 REMARK 465 SER A 702 REMARK 465 PHE A 703 REMARK 465 ASN A 704 REMARK 465 VAL A 705 REMARK 465 THR A 706 REMARK 465 GLU A 707 REMARK 465 PRO A 708 REMARK 465 HIS A 709 REMARK 465 ILE A 710 REMARK 465 SER A 711 REMARK 465 ALA A 712 REMARK 465 SER A 713 REMARK 465 SER A 714 REMARK 465 LEU A 715 REMARK 465 GLU A 716 REMARK 465 TRP A 717 REMARK 465 ILE A 718 REMARK 465 ASP A 719 REMARK 465 PRO A 720 REMARK 465 ASP A 721 REMARK 465 SER A 722 REMARK 465 SER A 723 REMARK 465 LEU A 724 REMARK 465 ARG A 725 REMARK 465 ASP A 726 REMARK 465 HIS A 727 REMARK 465 ILE A 728 REMARK 465 ASN A 729 REMARK 465 VAL A 730 REMARK 465 ILE A 731 REMARK 465 VAL A 732 REMARK 465 GLY A 733 REMARK 465 ARG A 734 REMARK 465 ASP A 735 REMARK 465 LEU A 736 REMARK 465 SER A 737 REMARK 465 PHE A 738 REMARK 465 GLN A 739 REMARK 465 ASP A 740 REMARK 465 LEU A 741 REMARK 465 SER A 742 REMARK 465 GLU A 743 REMARK 465 THR A 744 REMARK 465 PRO A 745 REMARK 465 CYS A 746 REMARK 465 GLN A 747 REMARK 465 VAL A 748 REMARK 465 ASP A 749 REMARK 465 LEU A 750 REMARK 465 THR A 751 REMARK 465 THR A 752 REMARK 465 THR A 753 REMARK 465 SER A 754 REMARK 465 ILE A 755 REMARK 465 ASP A 756 REMARK 465 GLY A 757 REMARK 465 ALA A 758 REMARK 465 TRP A 759 REMARK 465 GLY A 760 REMARK 465 SER A 761 REMARK 465 GLY A 762 REMARK 465 VAL A 763 REMARK 465 GLY A 764 REMARK 465 PHE A 765 REMARK 465 ASN A 766 REMARK 465 LEU A 767 REMARK 465 ILE A 768 REMARK 465 CYS A 769 REMARK 465 SER A 770 REMARK 465 VAL A 771 REMARK 465 SER A 772 REMARK 465 LEU A 773 REMARK 465 THR A 774 REMARK 465 GLU A 775 REMARK 465 CYS A 776 REMARK 465 SER A 777 REMARK 465 THR A 778 REMARK 465 PHE A 779 REMARK 465 LEU A 780 REMARK 465 THR A 781 REMARK 465 SER A 782 REMARK 465 ILE A 783 REMARK 465 LYS A 784 REMARK 465 ALA A 785 REMARK 465 CYS A 786 REMARK 465 ASP A 787 REMARK 465 SER A 788 REMARK 465 ALA A 789 REMARK 465 MET A 790 REMARK 465 CYS A 791 REMARK 465 TYR A 792 REMARK 465 GLY A 793 REMARK 465 SER A 794 REMARK 465 THR A 795 REMARK 465 THR A 796 REMARK 465 ALA A 797 REMARK 465 ASN A 798 REMARK 465 LEU A 799 REMARK 465 VAL A 800 REMARK 465 ARG A 801 REMARK 465 GLY A 802 REMARK 465 GLN A 803 REMARK 465 ASN A 804 REMARK 465 THR A 805 REMARK 465 VAL A 806 REMARK 465 HIS A 807 REMARK 465 ILE A 808 REMARK 465 VAL A 809 REMARK 465 GLY A 810 REMARK 465 LYS A 811 REMARK 465 GLY A 812 REMARK 465 GLY A 813 REMARK 465 HIS A 814 REMARK 465 SER A 815 REMARK 465 GLY A 816 REMARK 465 SER A 817 REMARK 465 LYS A 818 REMARK 465 PHE A 819 REMARK 465 MET A 820 REMARK 465 CYS A 821 REMARK 465 CYS A 822 REMARK 465 HIS A 823 REMARK 465 ASP A 824 REMARK 465 THR A 825 REMARK 465 LYS A 826 REMARK 465 CYS A 827 REMARK 465 SER A 828 REMARK 465 SER A 829 REMARK 465 THR A 830 REMARK 465 GLY A 831 REMARK 465 LEU A 832 REMARK 465 VAL A 833 REMARK 465 ALA A 834 REMARK 465 ALA A 835 REMARK 465 ALA A 836 REMARK 465 PRO A 837 REMARK 465 HIS A 838 REMARK 465 LEU A 839 REMARK 465 ASP A 840 REMARK 465 ARG A 841 REMARK 465 VAL A 842 REMARK 465 THR A 843 REMARK 465 GLY A 844 REMARK 465 TYR A 845 REMARK 465 ASN A 846 REMARK 465 GLN A 847 REMARK 465 ALA A 848 REMARK 465 ASP A 849 REMARK 465 SER A 850 REMARK 465 ASP A 851 REMARK 465 LYS A 852 REMARK 465 ILE A 853 REMARK 465 PHE A 854 REMARK 465 ASP A 855 REMARK 465 ASP A 856 REMARK 465 GLY A 857 REMARK 465 ALA A 858 REMARK 465 PRO A 859 REMARK 465 GLU A 860 REMARK 465 GLY A 861 REMARK 465 LEU A 862 REMARK 465 VAL A 863 REMARK 465 PRO A 864 REMARK 465 ARG A 865 REMARK 465 GLY A 866 REMARK 465 SER A 867 REMARK 465 GLY A 868 REMARK 465 PRO A 869 REMARK 465 PHE A 870 REMARK 465 GLU A 871 REMARK 465 ASP A 872 REMARK 465 ASP A 873 REMARK 465 ASP A 874 REMARK 465 ASP A 875 REMARK 465 LYS A 876 REMARK 465 ALA A 877 REMARK 465 GLY A 878 REMARK 465 TRP A 879 REMARK 465 SER A 880 REMARK 465 HIS A 881 REMARK 465 PRO A 882 REMARK 465 GLN A 883 REMARK 465 PHE A 884 REMARK 465 GLU A 885 REMARK 465 LYS A 886 REMARK 465 GLY A 887 REMARK 465 GLY A 888 REMARK 465 GLY A 889 REMARK 465 SER A 890 REMARK 465 GLY A 891 REMARK 465 GLY A 892 REMARK 465 GLY A 893 REMARK 465 SER A 894 REMARK 465 GLY A 895 REMARK 465 GLY A 896 REMARK 465 GLY A 897 REMARK 465 SER A 898 REMARK 465 TRP A 899 REMARK 465 SER A 900 REMARK 465 HIS A 901 REMARK 465 PRO A 902 REMARK 465 GLN A 903 REMARK 465 PHE A 904 REMARK 465 GLU A 905 REMARK 465 LYS A 906 REMARK 465 ARG B 251 REMARK 465 SER B 252 REMARK 465 SER B 253 REMARK 465 ARG B 254 REMARK 465 GLY B 255 REMARK 465 ASP B 256 REMARK 465 THR B 257 REMARK 465 ARG B 258 REMARK 465 ASN B 259 REMARK 465 LEU B 260 REMARK 465 ASN B 261 REMARK 465 GLU B 262 REMARK 465 LEU B 263 REMARK 465 LYS B 264 REMARK 465 MET B 265 REMARK 465 GLU B 266 REMARK 465 CYS B 267 REMARK 465 PRO B 268 REMARK 465 HIS B 269 REMARK 465 THR B 270 REMARK 465 ILE B 271 REMARK 465 GLY B 272 REMARK 465 LEU B 273 REMARK 465 GLY B 274 REMARK 465 GLN B 275 REMARK 465 GLY B 276 REMARK 465 LEU B 277 REMARK 465 VAL B 278 REMARK 465 ILE B 279 REMARK 465 GLY B 280 REMARK 465 SER B 281 REMARK 465 ILE B 282 REMARK 465 GLU B 283 REMARK 465 LEU B 284 REMARK 465 PRO B 285 REMARK 465 PRO B 286 REMARK 465 VAL B 287 REMARK 465 PRO B 288 REMARK 465 LEU B 289 REMARK 465 ILE B 290 REMARK 465 GLN B 291 REMARK 465 VAL B 292 REMARK 465 GLU B 293 REMARK 465 SER B 294 REMARK 465 LEU B 295 REMARK 465 LYS B 296 REMARK 465 LEU B 297 REMARK 465 GLU B 298 REMARK 465 SER B 299 REMARK 465 SER B 300 REMARK 465 CYS B 301 REMARK 465 ASN B 302 REMARK 465 PHE B 303 REMARK 465 ASP B 304 REMARK 465 LEU B 305 REMARK 465 HIS B 306 REMARK 465 THR B 307 REMARK 465 SER B 308 REMARK 465 THR B 309 REMARK 465 SER B 310 REMARK 465 SER B 311 REMARK 465 GLN B 312 REMARK 465 GLN B 313 REMARK 465 ALA B 314 REMARK 465 PHE B 315 REMARK 465 THR B 316 REMARK 465 LYS B 317 REMARK 465 TRP B 318 REMARK 465 THR B 319 REMARK 465 TRP B 320 REMARK 465 GLU B 321 REMARK 465 VAL B 322 REMARK 465 LYS B 323 REMARK 465 SER B 324 REMARK 465 ASP B 325 REMARK 465 LEU B 326 REMARK 465 ALA B 327 REMARK 465 GLU B 328 REMARK 465 ASN B 329 REMARK 465 THR B 330 REMARK 465 GLN B 331 REMARK 465 ALA B 332 REMARK 465 SER B 333 REMARK 465 SER B 334 REMARK 465 THR B 335 REMARK 465 SER B 336 REMARK 465 PHE B 337 REMARK 465 GLN B 338 REMARK 465 THR B 339 REMARK 465 LYS B 340 REMARK 465 SER B 341 REMARK 465 SER B 342 REMARK 465 GLU B 343 REMARK 465 VAL B 344 REMARK 465 ASN B 345 REMARK 465 LEU B 346 REMARK 465 ARG B 347 REMARK 465 GLY B 348 REMARK 465 LEU B 349 REMARK 465 CYS B 350 REMARK 465 LEU B 351 REMARK 465 VAL B 352 REMARK 465 PRO B 353 REMARK 465 PRO B 354 REMARK 465 LEU B 355 REMARK 465 VAL B 356 REMARK 465 ILE B 357 REMARK 465 GLU B 358 REMARK 465 THR B 359 REMARK 465 ALA B 360 REMARK 465 ALA B 361 REMARK 465 ARG B 362 REMARK 465 THR B 363 REMARK 465 ARG B 364 REMARK 465 LYS B 365 REMARK 465 THR B 366 REMARK 465 ILE B 367 REMARK 465 ALA B 368 REMARK 465 CYS B 369 REMARK 465 PHE B 370 REMARK 465 ASP B 371 REMARK 465 LEU B 372 REMARK 465 SER B 373 REMARK 465 CYS B 374 REMARK 465 ASN B 375 REMARK 465 GLN B 376 REMARK 465 THR B 377 REMARK 465 THR B 378 REMARK 465 CYS B 379 REMARK 465 GLN B 380 REMARK 465 PRO B 381 REMARK 465 THR B 382 REMARK 465 VAL B 383 REMARK 465 PHE B 384 REMARK 465 LEU B 385 REMARK 465 MET B 386 REMARK 465 GLY B 387 REMARK 465 PRO B 388 REMARK 465 ILE B 389 REMARK 465 GLN B 390 REMARK 465 THR B 391 REMARK 465 CYS B 392 REMARK 465 ILE B 393 REMARK 465 THR B 394 REMARK 465 THR B 395 REMARK 465 LYS B 396 REMARK 465 SER B 397 REMARK 465 CYS B 398 REMARK 465 LEU B 399 REMARK 465 LEU B 400 REMARK 465 GLY B 401 REMARK 465 LEU B 402 REMARK 465 GLY B 403 REMARK 465 ASP B 404 REMARK 465 GLN B 405 REMARK 465 ARG B 406 REMARK 465 ILE B 407 REMARK 465 GLN B 408 REMARK 465 VAL B 409 REMARK 465 ASN B 410 REMARK 465 TYR B 411 REMARK 465 GLU B 412 REMARK 465 LYS B 413 REMARK 465 THR B 414 REMARK 465 TYR B 415 REMARK 465 CYS B 416 REMARK 465 VAL B 417 REMARK 465 SER B 418 REMARK 465 GLY B 419 REMARK 465 GLN B 420 REMARK 465 LEU B 421 REMARK 465 ILE B 422 REMARK 465 GLU B 423 REMARK 465 GLY B 424 REMARK 465 ILE B 425 REMARK 465 CYS B 426 REMARK 465 PHE B 427 REMARK 465 ASN B 428 REMARK 465 PRO B 429 REMARK 465 VAL B 430 REMARK 465 HIS B 431 REMARK 465 THR B 432 REMARK 465 MET B 433 REMARK 465 ALA B 434 REMARK 465 LEU B 435 REMARK 465 SER B 436 REMARK 465 GLN B 437 REMARK 465 PRO B 438 REMARK 465 SER B 439 REMARK 465 HIS B 440 REMARK 465 THR B 441 REMARK 465 TYR B 442 REMARK 465 ASP B 443 REMARK 465 ILE B 444 REMARK 465 VAL B 445 REMARK 465 THR B 446 REMARK 465 VAL B 447 REMARK 465 MET B 448 REMARK 465 VAL B 449 REMARK 465 ARG B 450 REMARK 465 CYS B 451 REMARK 465 PHE B 452 REMARK 465 LEU B 453 REMARK 465 ILE B 454 REMARK 465 VAL B 455 REMARK 465 LYS B 456 REMARK 465 LYS B 457 REMARK 465 VAL B 458 REMARK 465 THR B 459 REMARK 465 THR B 460 REMARK 465 GLY B 461 REMARK 465 ASP B 462 REMARK 465 SER B 463 REMARK 465 MET B 464 REMARK 465 LYS B 465 REMARK 465 ILE B 466 REMARK 465 GLU B 467 REMARK 465 LYS B 468 REMARK 465 SER B 469 REMARK 465 PHE B 470 REMARK 465 GLU B 471 REMARK 465 THR B 472 REMARK 465 LEU B 473 REMARK 465 VAL B 474 REMARK 465 GLN B 475 REMARK 465 LYS B 476 REMARK 465 THR B 477 REMARK 465 GLY B 478 REMARK 465 CYS B 479 REMARK 465 THR B 480 REMARK 465 ASP B 481 REMARK 465 ASN B 482 REMARK 465 GLY B 483 REMARK 465 PHE B 484 REMARK 465 GLN B 485 REMARK 465 GLY B 486 REMARK 465 TYR B 487 REMARK 465 TYR B 488 REMARK 465 VAL B 489 REMARK 465 CYS B 490 REMARK 465 LEU B 491 REMARK 465 ILE B 492 REMARK 465 GLY B 493 REMARK 465 SER B 494 REMARK 465 SER B 495 REMARK 465 SER B 496 REMARK 465 GLU B 497 REMARK 465 PRO B 498 REMARK 465 LEU B 499 REMARK 465 TYR B 500 REMARK 465 ILE B 501 REMARK 465 PRO B 502 REMARK 465 THR B 503 REMARK 465 LEU B 504 REMARK 465 ASP B 505 REMARK 465 ASP B 506 REMARK 465 TYR B 507 REMARK 465 ARG B 508 REMARK 465 SER B 509 REMARK 465 ALA B 510 REMARK 465 GLU B 511 REMARK 465 VAL B 512 REMARK 465 LEU B 513 REMARK 465 SER B 514 REMARK 465 ARG B 515 REMARK 465 MET B 516 REMARK 465 ALA B 517 REMARK 465 PHE B 518 REMARK 465 ALA B 519 REMARK 465 PRO B 520 REMARK 465 HIS B 521 REMARK 465 GLY B 522 REMARK 465 GLU B 523 REMARK 465 ASP B 524 REMARK 465 HIS B 525 REMARK 465 ASP B 526 REMARK 465 ILE B 527 REMARK 465 GLU B 528 REMARK 465 LYS B 529 REMARK 465 ASN B 530 REMARK 465 ALA B 531 REMARK 465 ILE B 532 REMARK 465 SER B 533 REMARK 465 ALA B 534 REMARK 465 MET B 535 REMARK 465 ARG B 536 REMARK 465 ILE B 537 REMARK 465 VAL B 538 REMARK 465 GLY B 539 REMARK 465 LYS B 540 REMARK 465 VAL B 541 REMARK 465 THR B 542 REMARK 465 GLY B 543 REMARK 465 LYS B 544 REMARK 465 ALA B 545 REMARK 465 PRO B 546 REMARK 465 SER B 547 REMARK 465 THR B 548 REMARK 465 GLU B 549 REMARK 465 SER B 550 REMARK 465 SER B 551 REMARK 465 ASP B 552 REMARK 465 THR B 553 REMARK 465 VAL B 554 REMARK 465 GLN B 555 REMARK 465 GLY B 556 REMARK 465 ILE B 557 REMARK 465 ALA B 558 REMARK 465 PHE B 559 REMARK 465 SER B 560 REMARK 465 GLY B 561 REMARK 465 ASN B 562 REMARK 465 PRO B 563 REMARK 465 LEU B 564 REMARK 465 TYR B 565 REMARK 465 THR B 566 REMARK 465 SER B 567 REMARK 465 THR B 568 REMARK 465 GLY B 569 REMARK 465 VAL B 570 REMARK 465 LEU B 571 REMARK 465 THR B 572 REMARK 465 ALA B 573 REMARK 465 LYS B 574 REMARK 465 ASP B 575 REMARK 465 ASP B 576 REMARK 465 PRO B 577 REMARK 465 VAL B 578 REMARK 465 TYR B 579 REMARK 465 VAL B 580 REMARK 465 TRP B 581 REMARK 465 ALA B 582 REMARK 465 PRO B 583 REMARK 465 GLY B 584 REMARK 465 ILE B 585 REMARK 465 MET B 586 REMARK 465 MET B 587 REMARK 465 GLU B 588 REMARK 465 GLY B 589 REMARK 465 ASN B 590 REMARK 465 HIS B 591 REMARK 465 SER B 592 REMARK 465 VAL B 593 REMARK 465 CYS B 594 REMARK 465 ASP B 595 REMARK 465 LYS B 596 REMARK 465 LYS B 597 REMARK 465 THR B 598 REMARK 465 LEU B 599 REMARK 465 PRO B 600 REMARK 465 LEU B 601 REMARK 465 THR B 602 REMARK 465 TRP B 603 REMARK 465 THR B 604 REMARK 465 GLY B 605 REMARK 465 PHE B 606 REMARK 465 ILE B 607 REMARK 465 PRO B 608 REMARK 465 LEU B 609 REMARK 465 PRO B 610 REMARK 465 GLY B 611 REMARK 465 GLU B 612 REMARK 465 ILE B 613 REMARK 465 GLU B 614 REMARK 465 GLY B 615 REMARK 465 GLY B 616 REMARK 465 SER B 617 REMARK 465 GLY B 618 REMARK 465 LEU B 619 REMARK 465 VAL B 620 REMARK 465 PRO B 621 REMARK 465 ARG B 622 REMARK 465 GLY B 623 REMARK 465 SER B 624 REMARK 465 GLY B 625 REMARK 465 GLY B 626 REMARK 465 GLY B 627 REMARK 465 SER B 628 REMARK 465 GLY B 629 REMARK 465 GLY B 630 REMARK 465 GLY B 631 REMARK 465 SER B 632 REMARK 465 TRP B 633 REMARK 465 SER B 634 REMARK 465 HIS B 635 REMARK 465 PRO B 636 REMARK 465 GLN B 637 REMARK 465 PHE B 638 REMARK 465 GLU B 639 REMARK 465 LYS B 640 REMARK 465 GLY B 641 REMARK 465 GLY B 642 REMARK 465 GLY B 643 REMARK 465 THR B 644 REMARK 465 GLY B 645 REMARK 465 GLY B 646 REMARK 465 GLY B 647 REMARK 465 THR B 648 REMARK 465 LEU B 649 REMARK 465 VAL B 650 REMARK 465 PRO B 651 REMARK 465 ARG B 652 REMARK 465 GLY B 653 REMARK 465 SER B 654 REMARK 465 GLY B 655 REMARK 465 THR B 656 REMARK 465 GLY B 657 REMARK 465 GLY B 658 REMARK 465 HIS B 1071 REMARK 465 LEU B 1072 REMARK 465 ASP B 1073 REMARK 465 ARG B 1074 REMARK 465 VAL B 1075 REMARK 465 THR B 1076 REMARK 465 GLY B 1077 REMARK 465 TYR B 1078 REMARK 465 ASN B 1079 REMARK 465 GLN B 1080 REMARK 465 ALA B 1081 REMARK 465 ASP B 1082 REMARK 465 GLY B 1094 REMARK 465 LEU B 1095 REMARK 465 VAL B 1096 REMARK 465 PRO B 1097 REMARK 465 ARG B 1098 REMARK 465 GLY B 1099 REMARK 465 SER B 1100 REMARK 465 GLY B 1101 REMARK 465 PRO B 1102 REMARK 465 PHE B 1103 REMARK 465 GLU B 1104 REMARK 465 ASP B 1105 REMARK 465 ASP B 1106 REMARK 465 ASP B 1107 REMARK 465 ASP B 1108 REMARK 465 LYS B 1109 REMARK 465 ALA B 1110 REMARK 465 GLY B 1111 REMARK 465 TRP B 1112 REMARK 465 SER B 1113 REMARK 465 HIS B 1114 REMARK 465 PRO B 1115 REMARK 465 GLN B 1116 REMARK 465 PHE B 1117 REMARK 465 GLU B 1118 REMARK 465 LYS B 1119 REMARK 465 GLY B 1120 REMARK 465 GLY B 1121 REMARK 465 GLY B 1122 REMARK 465 SER B 1123 REMARK 465 GLY B 1124 REMARK 465 GLY B 1125 REMARK 465 GLY B 1126 REMARK 465 SER B 1127 REMARK 465 GLY B 1128 REMARK 465 GLY B 1129 REMARK 465 GLY B 1130 REMARK 465 SER B 1131 REMARK 465 TRP B 1132 REMARK 465 SER B 1133 REMARK 465 HIS B 1134 REMARK 465 PRO B 1135 REMARK 465 GLN B 1136 REMARK 465 PHE B 1137 REMARK 465 GLU B 1138 REMARK 465 LYS B 1139 REMARK 465 ARG H -1 REMARK 465 SER H 0 REMARK 465 ARG H 71 REMARK 465 ASP H 72 REMARK 465 ASN H 73 REMARK 465 SER H 74 REMARK 465 GLY H 114 REMARK 465 THR H 115 REMARK 465 GLY H 116 REMARK 465 GLY H 117 REMARK 465 SER H 118 REMARK 465 GLY H 119 REMARK 465 GLY H 120 REMARK 465 GLY H 121 REMARK 465 GLY H 122 REMARK 465 SER H 123 REMARK 465 GLY H 124 REMARK 465 GLY H 125 REMARK 465 GLY H 126 REMARK 465 GLY H 127 REMARK 465 SER H 128 REMARK 465 GLY H 129 REMARK 465 GLY H 130 REMARK 465 GLY H 131 REMARK 465 ALA H 132 REMARK 465 SER H 133 REMARK 465 ASP H 134 REMARK 465 ILE H 135 REMARK 465 VAL H 136 REMARK 465 MET H 137 REMARK 465 THR H 138 REMARK 465 GLN H 139 REMARK 465 SER H 140 REMARK 465 PRO H 141 REMARK 465 LEU H 142 REMARK 465 SER H 143 REMARK 465 LEU H 144 REMARK 465 PRO H 145 REMARK 465 VAL H 146 REMARK 465 THR H 147 REMARK 465 PRO H 148 REMARK 465 GLY H 149 REMARK 465 GLU H 150 REMARK 465 PRO H 151 REMARK 465 ALA H 152 REMARK 465 SER H 153 REMARK 465 ILE H 154 REMARK 465 SER H 155 REMARK 465 CYS H 156 REMARK 465 ARG H 157 REMARK 465 SER H 158 REMARK 465 SER H 159 REMARK 465 GLN H 160 REMARK 465 SER H 161 REMARK 465 LEU H 162 REMARK 465 LEU H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 TYR H 166 REMARK 465 GLY H 167 REMARK 465 TYR H 168 REMARK 465 ASN H 169 REMARK 465 CYS H 170 REMARK 465 LEU H 171 REMARK 465 ASP H 172 REMARK 465 TRP H 173 REMARK 465 TYR H 174 REMARK 465 LEU H 175 REMARK 465 GLN H 176 REMARK 465 ARG H 177 REMARK 465 PRO H 178 REMARK 465 GLY H 179 REMARK 465 GLN H 180 REMARK 465 SER H 181 REMARK 465 PRO H 182 REMARK 465 GLN H 183 REMARK 465 LEU H 184 REMARK 465 LEU H 185 REMARK 465 ILE H 186 REMARK 465 SER H 187 REMARK 465 LEU H 188 REMARK 465 GLY H 189 REMARK 465 SER H 190 REMARK 465 TYR H 191 REMARK 465 ARG H 192 REMARK 465 ALA H 193 REMARK 465 SER H 194 REMARK 465 GLY H 195 REMARK 465 VAL H 196 REMARK 465 PRO H 197 REMARK 465 ASP H 198 REMARK 465 ARG H 199 REMARK 465 PHE H 200 REMARK 465 SER H 201 REMARK 465 GLY H 202 REMARK 465 SER H 203 REMARK 465 GLY H 204 REMARK 465 SER H 205 REMARK 465 GLY H 206 REMARK 465 THR H 207 REMARK 465 ASP H 208 REMARK 465 PHE H 209 REMARK 465 THR H 210 REMARK 465 LEU H 211 REMARK 465 LYS H 212 REMARK 465 ILE H 213 REMARK 465 SER H 214 REMARK 465 ARG H 215 REMARK 465 VAL H 216 REMARK 465 GLU H 217 REMARK 465 ALA H 218 REMARK 465 GLU H 219 REMARK 465 ASP H 220 REMARK 465 VAL H 221 REMARK 465 GLY H 222 REMARK 465 VAL H 223 REMARK 465 TYR H 224 REMARK 465 TYR H 225 REMARK 465 CYS H 226 REMARK 465 MET H 227 REMARK 465 GLN H 228 REMARK 465 ALA H 229 REMARK 465 LEU H 230 REMARK 465 HIS H 231 REMARK 465 PRO H 232 REMARK 465 PHE H 233 REMARK 465 THR H 234 REMARK 465 PHE H 235 REMARK 465 GLY H 236 REMARK 465 GLY H 237 REMARK 465 GLY H 238 REMARK 465 THR H 239 REMARK 465 LYS H 240 REMARK 465 VAL H 241 REMARK 465 GLU H 242 REMARK 465 ILE H 243 REMARK 465 LYS H 244 REMARK 465 GLY H 245 REMARK 465 PRO H 246 REMARK 465 PHE H 247 REMARK 465 GLU H 248 REMARK 465 ASP H 249 REMARK 465 ASP H 250 REMARK 465 ASP H 251 REMARK 465 ASP H 252 REMARK 465 LYS H 253 REMARK 465 ALA H 254 REMARK 465 GLY H 255 REMARK 465 TRP H 256 REMARK 465 SER H 257 REMARK 465 HIS H 258 REMARK 465 PRO H 259 REMARK 465 GLN H 260 REMARK 465 PHE H 261 REMARK 465 GLU H 262 REMARK 465 LYS H 263 REMARK 465 GLY H 264 REMARK 465 GLY H 265 REMARK 465 GLY H 266 REMARK 465 SER H 267 REMARK 465 GLY H 268 REMARK 465 GLY H 269 REMARK 465 GLY H 270 REMARK 465 SER H 271 REMARK 465 GLY H 272 REMARK 465 GLY H 273 REMARK 465 GLY H 274 REMARK 465 SER H 275 REMARK 465 TRP H 276 REMARK 465 SER H 277 REMARK 465 HIS H 278 REMARK 465 PRO H 279 REMARK 465 GLN H 280 REMARK 465 PHE H 281 REMARK 465 GLU H 282 REMARK 465 LYS H 283 REMARK 465 ARG L -147 REMARK 465 SER L -146 REMARK 465 GLN L -145 REMARK 465 VAL L -144 REMARK 465 GLN L -143 REMARK 465 LEU L -142 REMARK 465 VAL L -141 REMARK 465 GLU L -140 REMARK 465 SER L -139 REMARK 465 GLY L -138 REMARK 465 GLY L -137 REMARK 465 GLY L -136 REMARK 465 VAL L -135 REMARK 465 VAL L -134 REMARK 465 GLN L -133 REMARK 465 PRO L -132 REMARK 465 GLY L -131 REMARK 465 ARG L -130 REMARK 465 SER L -129 REMARK 465 LEU L -128 REMARK 465 ARG L -127 REMARK 465 LEU L -126 REMARK 465 SER L -125 REMARK 465 CYS L -124 REMARK 465 ALA L -123 REMARK 465 ALA L -122 REMARK 465 SER L -121 REMARK 465 GLY L -120 REMARK 465 PHE L -119 REMARK 465 THR L -118 REMARK 465 PHE L -117 REMARK 465 SER L -116 REMARK 465 SER L -115 REMARK 465 TYR L -114 REMARK 465 ALA L -113 REMARK 465 MET L -112 REMARK 465 HIS L -111 REMARK 465 TRP L -110 REMARK 465 VAL L -109 REMARK 465 ARG L -108 REMARK 465 GLN L -107 REMARK 465 ALA L -106 REMARK 465 PRO L -105 REMARK 465 GLY L -104 REMARK 465 LYS L -103 REMARK 465 GLY L -102 REMARK 465 LEU L -101 REMARK 465 GLU L -100 REMARK 465 TRP L -99 REMARK 465 VAL L -98 REMARK 465 ALA L -97 REMARK 465 VAL L -96 REMARK 465 THR L -95 REMARK 465 TRP L -94 REMARK 465 PHE L -93 REMARK 465 ASP L -92 REMARK 465 VAL L -91 REMARK 465 SER L -90 REMARK 465 LYS L -89 REMARK 465 LYS L -88 REMARK 465 ASP L -87 REMARK 465 TYR L -86 REMARK 465 ALA L -85 REMARK 465 ASP L -84 REMARK 465 SER L -83 REMARK 465 VAL L -82 REMARK 465 LYS L -81 REMARK 465 GLY L -80 REMARK 465 ARG L -79 REMARK 465 PHE L -78 REMARK 465 THR L -77 REMARK 465 ILE L -76 REMARK 465 SER L -75 REMARK 465 ARG L -74 REMARK 465 ASP L -73 REMARK 465 ASN L -72 REMARK 465 SER L -71 REMARK 465 LYS L -70 REMARK 465 ASN L -69 REMARK 465 THR L -68 REMARK 465 LEU L -67 REMARK 465 TYR L -66 REMARK 465 LEU L -65 REMARK 465 GLN L -64 REMARK 465 MET L -63 REMARK 465 ASN L -62 REMARK 465 SER L -61 REMARK 465 LEU L -60 REMARK 465 ARG L -59 REMARK 465 ALA L -58 REMARK 465 GLU L -57 REMARK 465 ASP L -56 REMARK 465 THR L -55 REMARK 465 ALA L -54 REMARK 465 VAL L -53 REMARK 465 TYR L -52 REMARK 465 TYR L -51 REMARK 465 CYS L -50 REMARK 465 ALA L -49 REMARK 465 ARG L -48 REMARK 465 ASN L -47 REMARK 465 LEU L -46 REMARK 465 ILE L -45 REMARK 465 ARG L -44 REMARK 465 TYR L -43 REMARK 465 SER L -42 REMARK 465 GLY L -41 REMARK 465 SER L -40 REMARK 465 TYR L -39 REMARK 465 PHE L -38 REMARK 465 PRO L -37 REMARK 465 VAL L -36 REMARK 465 HIS L -35 REMARK 465 GLY L -34 REMARK 465 MET L -33 REMARK 465 ASP L -32 REMARK 465 VAL L -31 REMARK 465 TRP L -30 REMARK 465 GLY L -29 REMARK 465 GLN L -28 REMARK 465 GLY L -27 REMARK 465 THR L -26 REMARK 465 THR L -25 REMARK 465 VAL L -24 REMARK 465 THR L -23 REMARK 465 VAL L -22 REMARK 465 SER L -21 REMARK 465 SER L -20 REMARK 465 GLY L -19 REMARK 465 THR L -18 REMARK 465 GLY L -17 REMARK 465 GLY L -16 REMARK 465 SER L -15 REMARK 465 GLY L -14 REMARK 465 GLY L -13 REMARK 465 GLY L -12 REMARK 465 GLY L -11 REMARK 465 SER L -10 REMARK 465 GLY L -9 REMARK 465 GLY L -8 REMARK 465 GLY L -7 REMARK 465 GLY L -6 REMARK 465 SER L -5 REMARK 465 GLY L -4 REMARK 465 GLY L -3 REMARK 465 GLY L -2 REMARK 465 ALA L -1 REMARK 465 SER L 0 REMARK 465 ILE L 105 REMARK 465 LYS L 106 REMARK 465 GLY L 107 REMARK 465 PRO L 108 REMARK 465 PHE L 109 REMARK 465 GLU L 110 REMARK 465 ASP L 111 REMARK 465 ASP L 112 REMARK 465 ASP L 113 REMARK 465 ASP L 114 REMARK 465 LYS L 115 REMARK 465 ALA L 116 REMARK 465 GLY L 117 REMARK 465 TRP L 118 REMARK 465 SER L 119 REMARK 465 HIS L 120 REMARK 465 PRO L 121 REMARK 465 GLN L 122 REMARK 465 PHE L 123 REMARK 465 GLU L 124 REMARK 465 LYS L 125 REMARK 465 GLY L 126 REMARK 465 GLY L 127 REMARK 465 GLY L 128 REMARK 465 SER L 129 REMARK 465 GLY L 130 REMARK 465 GLY L 131 REMARK 465 GLY L 132 REMARK 465 SER L 133 REMARK 465 GLY L 134 REMARK 465 GLY L 135 REMARK 465 GLY L 136 REMARK 465 SER L 137 REMARK 465 TRP L 138 REMARK 465 SER L 139 REMARK 465 HIS L 140 REMARK 465 PRO L 141 REMARK 465 GLN L 142 REMARK 465 PHE L 143 REMARK 465 GLU L 144 REMARK 465 LYS L 145 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ASP L 1 CG OD1 OD2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER A 66 -79.96 -94.96 REMARK 500 ASN A 69 58.69 -105.47 REMARK 500 ASP A 92 49.93 -96.03 REMARK 500 LEU A 122 -8.19 70.30 REMARK 500 ASN A 142 -150.62 -107.90 REMARK 500 LYS A 163 -60.51 63.30 REMARK 500 SER A 206 -159.33 -79.79 REMARK 500 HIS A 207 -92.59 -111.97 REMARK 500 TYR A 209 -141.10 -146.32 REMARK 500 THR A 227 -50.87 -131.96 REMARK 500 ASP A 248 49.07 -98.55 REMARK 500 HIS A 292 49.78 -108.22 REMARK 500 GLU A 295 9.93 -68.36 REMARK 500 ASN A 297 -41.51 69.83 REMARK 500 LEU A 331 -70.17 -124.25 REMARK 500 SER B 692 16.46 57.91 REMARK 500 ASN B 706 79.65 56.54 REMARK 500 SER B 853 -0.38 68.73 REMARK 500 THR B 874 -84.51 -134.86 REMARK 500 THR B 909 -59.70 -135.30 REMARK 500 SER B 944 -168.69 -122.28 REMARK 500 SER B 946 -6.54 -140.00 REMARK 500 GLU B 976 -72.31 -60.69 REMARK 500 TRP B 992 -152.74 -93.52 REMARK 500 GLU B1008 -57.54 63.23 REMARK 500 ASP B1020 -143.77 -115.35 REMARK 500 LYS B1044 116.83 -161.19 REMARK 500 ASP B1057 -85.12 57.96 REMARK 500 ARG H 16 -150.63 -83.11 REMARK 500 PHE H 52A 76.19 52.83 REMARK 500 ASP H 53 -124.49 52.85 REMARK 500 PRO L 8 116.49 -12.57 REMARK 500 ARG L 77 78.18 50.77 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 SER L 7 PRO L 8 -133.26 REMARK 500 REMARK 500 REMARK: NULL DBREF1 7QQB A 20 381 UNP A0A0B4U5I0_9VIRU DBREF2 7QQB A A0A0B4U5I0 20 381 DBREF1 7QQB A 426 860 UNP A0A6M3W7M6_9VIRU DBREF2 7QQB A A0A6M3W7M6 659 1093 DBREF1 7QQB B 253 614 UNP A0A0B4U5I0_9VIRU DBREF2 7QQB B A0A0B4U5I0 20 381 DBREF1 7QQB B 659 1093 UNP A0A6M3W7M6_9VIRU DBREF2 7QQB B A0A6M3W7M6 659 1093 DBREF 7QQB H -1 283 PDB 7QQB 7QQB -1 283 DBREF 7QQB L -147 145 PDB 7QQB 7QQB -147 145 SEQADV 7QQB ARG A 18 UNP A0A0B4U5I EXPRESSION TAG SEQADV 7QQB SER A 19 UNP A0A0B4U5I EXPRESSION TAG SEQADV 7QQB ASP A 362 UNP A0A0B4U5I GLU 362 CONFLICT SEQADV 7QQB GLY A 382 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 383 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 384 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 385 UNP A0A0B4U5I LINKER SEQADV 7QQB LEU A 386 UNP A0A0B4U5I LINKER SEQADV 7QQB VAL A 387 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO A 388 UNP A0A0B4U5I LINKER SEQADV 7QQB ARG A 389 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 390 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 391 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 392 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 393 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 394 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 395 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 396 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 397 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 398 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 399 UNP A0A0B4U5I LINKER SEQADV 7QQB TRP A 400 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 401 UNP A0A0B4U5I LINKER SEQADV 7QQB HIS A 402 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO A 403 UNP A0A0B4U5I LINKER SEQADV 7QQB GLN A 404 UNP A0A0B4U5I LINKER SEQADV 7QQB PHE A 405 UNP A0A0B4U5I LINKER SEQADV 7QQB GLU A 406 UNP A0A0B4U5I LINKER SEQADV 7QQB LYS A 407 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 408 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 409 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 410 UNP A0A0B4U5I LINKER SEQADV 7QQB THR A 411 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 412 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 413 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 414 UNP A0A0B4U5I LINKER SEQADV 7QQB THR A 415 UNP A0A0B4U5I LINKER SEQADV 7QQB LEU A 416 UNP A0A0B4U5I LINKER SEQADV 7QQB VAL A 417 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO A 418 UNP A0A0B4U5I LINKER SEQADV 7QQB ARG A 419 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 420 UNP A0A0B4U5I LINKER SEQADV 7QQB SER A 421 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 422 UNP A0A0B4U5I LINKER SEQADV 7QQB THR A 423 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 424 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 425 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY A 861 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LEU A 862 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB VAL A 863 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO A 864 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ARG A 865 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 866 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 867 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 868 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO A 869 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE A 870 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU A 871 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP A 872 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP A 873 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP A 874 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP A 875 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS A 876 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ALA A 877 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 878 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB TRP A 879 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 880 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB HIS A 881 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO A 882 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLN A 883 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE A 884 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU A 885 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS A 886 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 887 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 888 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 889 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 890 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 891 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 892 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 893 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 894 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 895 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 896 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY A 897 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 898 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB TRP A 899 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER A 900 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB HIS A 901 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO A 902 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLN A 903 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE A 904 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU A 905 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS A 906 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ARG B 251 UNP A0A0B4U5I EXPRESSION TAG SEQADV 7QQB SER B 252 UNP A0A0B4U5I EXPRESSION TAG SEQADV 7QQB ASP B 595 UNP A0A0B4U5I GLU 362 CONFLICT SEQADV 7QQB GLY B 615 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 616 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 617 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 618 UNP A0A0B4U5I LINKER SEQADV 7QQB LEU B 619 UNP A0A0B4U5I LINKER SEQADV 7QQB VAL B 620 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO B 621 UNP A0A0B4U5I LINKER SEQADV 7QQB ARG B 622 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 623 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 624 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 625 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 626 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 627 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 628 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 629 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 630 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 631 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 632 UNP A0A0B4U5I LINKER SEQADV 7QQB TRP B 633 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 634 UNP A0A0B4U5I LINKER SEQADV 7QQB HIS B 635 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO B 636 UNP A0A0B4U5I LINKER SEQADV 7QQB GLN B 637 UNP A0A0B4U5I LINKER SEQADV 7QQB PHE B 638 UNP A0A0B4U5I LINKER SEQADV 7QQB GLU B 639 UNP A0A0B4U5I LINKER SEQADV 7QQB LYS B 640 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 641 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 642 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 643 UNP A0A0B4U5I LINKER SEQADV 7QQB THR B 644 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 645 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 646 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 647 UNP A0A0B4U5I LINKER SEQADV 7QQB THR B 648 UNP A0A0B4U5I LINKER SEQADV 7QQB LEU B 649 UNP A0A0B4U5I LINKER SEQADV 7QQB VAL B 650 UNP A0A0B4U5I LINKER SEQADV 7QQB PRO B 651 UNP A0A0B4U5I LINKER SEQADV 7QQB ARG B 652 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 653 UNP A0A0B4U5I LINKER SEQADV 7QQB SER B 654 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 655 UNP A0A0B4U5I LINKER SEQADV 7QQB THR B 656 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 657 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 658 UNP A0A0B4U5I LINKER SEQADV 7QQB GLY B 1094 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LEU B 1095 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB VAL B 1096 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO B 1097 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ARG B 1098 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1099 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1100 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1101 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO B 1102 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE B 1103 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU B 1104 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP B 1105 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP B 1106 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP B 1107 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ASP B 1108 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS B 1109 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB ALA B 1110 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1111 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB TRP B 1112 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1113 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB HIS B 1114 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO B 1115 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLN B 1116 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE B 1117 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU B 1118 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS B 1119 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1120 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1121 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1122 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1123 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1124 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1125 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1126 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1127 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1128 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1129 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLY B 1130 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1131 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB TRP B 1132 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB SER B 1133 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB HIS B 1134 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PRO B 1135 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLN B 1136 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB PHE B 1137 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB GLU B 1138 UNP A0A6M3W7M EXPRESSION TAG SEQADV 7QQB LYS B 1139 UNP A0A6M3W7M EXPRESSION TAG SEQRES 1 A 889 ARG SER SER ARG GLY ASP THR ARG ASN LEU ASN GLU LEU SEQRES 2 A 889 LYS MET GLU CYS PRO HIS THR ILE GLY LEU GLY GLN GLY SEQRES 3 A 889 LEU VAL ILE GLY SER ILE GLU LEU PRO PRO VAL PRO LEU SEQRES 4 A 889 ILE GLN VAL GLU SER LEU LYS LEU GLU SER SER CYS ASN SEQRES 5 A 889 PHE ASP LEU HIS THR SER THR SER SER GLN GLN ALA PHE SEQRES 6 A 889 THR LYS TRP THR TRP GLU VAL LYS SER ASP LEU ALA GLU SEQRES 7 A 889 ASN THR GLN ALA SER SER THR SER PHE GLN THR LYS SER SEQRES 8 A 889 SER GLU VAL ASN LEU ARG GLY LEU CYS LEU VAL PRO PRO SEQRES 9 A 889 LEU VAL ILE GLU THR ALA ALA ARG THR ARG LYS THR ILE SEQRES 10 A 889 ALA CYS PHE ASP LEU SER CYS ASN GLN THR THR CYS GLN SEQRES 11 A 889 PRO THR VAL PHE LEU MET GLY PRO ILE GLN THR CYS ILE SEQRES 12 A 889 THR THR LYS SER CYS LEU LEU GLY LEU GLY ASP GLN ARG SEQRES 13 A 889 ILE GLN VAL ASN TYR GLU LYS THR TYR CYS VAL SER GLY SEQRES 14 A 889 GLN LEU ILE GLU GLY ILE CYS PHE ASN PRO VAL HIS THR SEQRES 15 A 889 MET ALA LEU SER GLN PRO SER HIS THR TYR ASP ILE VAL SEQRES 16 A 889 THR VAL MET VAL ARG CYS PHE LEU ILE VAL LYS LYS VAL SEQRES 17 A 889 THR THR GLY ASP SER MET LYS ILE GLU LYS SER PHE GLU SEQRES 18 A 889 THR LEU VAL GLN LYS THR GLY CYS THR ASP ASN GLY PHE SEQRES 19 A 889 GLN GLY TYR TYR VAL CYS LEU ILE GLY SER SER SER GLU SEQRES 20 A 889 PRO LEU TYR ILE PRO THR LEU ASP ASP TYR ARG SER ALA SEQRES 21 A 889 GLU VAL LEU SER ARG MET ALA PHE ALA PRO HIS GLY GLU SEQRES 22 A 889 ASP HIS ASP ILE GLU LYS ASN ALA ILE SER ALA MET ARG SEQRES 23 A 889 ILE VAL GLY LYS VAL THR GLY LYS ALA PRO SER THR GLU SEQRES 24 A 889 SER SER ASP THR VAL GLN GLY ILE ALA PHE SER GLY ASN SEQRES 25 A 889 PRO LEU TYR THR SER THR GLY VAL LEU THR ALA LYS ASP SEQRES 26 A 889 ASP PRO VAL TYR VAL TRP ALA PRO GLY ILE MET MET GLU SEQRES 27 A 889 GLY ASN HIS SER VAL CYS ASP LYS LYS THR LEU PRO LEU SEQRES 28 A 889 THR TRP THR GLY PHE ILE PRO LEU PRO GLY GLU ILE GLU SEQRES 29 A 889 GLY GLY SER GLY LEU VAL PRO ARG GLY SER GLY GLY GLY SEQRES 30 A 889 SER GLY GLY GLY SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 31 A 889 GLY GLY GLY THR GLY GLY GLY THR LEU VAL PRO ARG GLY SEQRES 32 A 889 SER GLY THR GLY GLY GLU THR GLN ASN LEU ASN SER GLY SEQRES 33 A 889 TRP THR ASP THR ALA HIS GLY SER GLY VAL ILE PRO MET SEQRES 34 A 889 ARG THR ASP LEU GLU LEU ASP PHE SER LEU PRO SER SER SEQRES 35 A 889 ALA SER TYR THR TYR ARG ARG GLN LEU GLN ASN PRO ALA SEQRES 36 A 889 ASN GLU GLN GLU LYS ILE PRO PHE HIS LEU GLN ILE SER SEQRES 37 A 889 LYS GLN VAL ILE HIS ALA GLU ILE GLN HIS LEU GLY HIS SEQRES 38 A 889 TRP MET ASP GLY THR PHE ASN LEU LYS THR ALA PHE HIS SEQRES 39 A 889 CYS TYR GLY SER CYS GLU LYS TYR ALA TYR PRO TRP GLN SEQRES 40 A 889 THR ALA GLY CYS PHE VAL GLU LYS ASP TYR GLU TYR GLU SEQRES 41 A 889 SER GLY TRP GLY CYS ASN PRO ALA ASP CYS PRO GLY VAL SEQRES 42 A 889 GLY THR GLY CYS THR ALA CYS GLY VAL TYR LEU ASP LYS SEQRES 43 A 889 LEU LYS SER VAL GLY LYS ALA PHE LYS ILE VAL SER LEU SEQRES 44 A 889 ARG TYR THR ARG LYS ALA CYS ILE GLN LEU GLY THR GLU SEQRES 45 A 889 GLN THR CYS LYS ASN VAL ASP SER ASN ASP CYS LEU VAL SEQRES 46 A 889 THR THR SER VAL LYS VAL CYS LEU ILE GLY THR VAL SER SEQRES 47 A 889 LYS PHE GLN PRO SER ASP THR LEU LEU PHE LEU GLY PRO SEQRES 48 A 889 LEU GLU GLN GLY GLY LEU ILE PHE LYS GLN TRP CYS THR SEQRES 49 A 889 THR THR CYS GLN PHE GLY ASP PRO GLY ASP ILE MET SER SEQRES 50 A 889 THR PRO VAL GLY MET LYS CYS PRO GLU LEU SER GLY SER SEQRES 51 A 889 PHE ARG LYS LYS CYS ALA PHE ALA THR THR PRO VAL CYS SEQRES 52 A 889 GLN PHE ASP GLY ASN THR ILE SER GLY TYR LYS ARG MET SEQRES 53 A 889 ILE ALA THR LYS ASP SER PHE GLN SER PHE ASN VAL THR SEQRES 54 A 889 GLU PRO HIS ILE SER ALA SER SER LEU GLU TRP ILE ASP SEQRES 55 A 889 PRO ASP SER SER LEU ARG ASP HIS ILE ASN VAL ILE VAL SEQRES 56 A 889 GLY ARG ASP LEU SER PHE GLN ASP LEU SER GLU THR PRO SEQRES 57 A 889 CYS GLN VAL ASP LEU THR THR THR SER ILE ASP GLY ALA SEQRES 58 A 889 TRP GLY SER GLY VAL GLY PHE ASN LEU ILE CYS SER VAL SEQRES 59 A 889 SER LEU THR GLU CYS SER THR PHE LEU THR SER ILE LYS SEQRES 60 A 889 ALA CYS ASP SER ALA MET CYS TYR GLY SER THR THR ALA SEQRES 61 A 889 ASN LEU VAL ARG GLY GLN ASN THR VAL HIS ILE VAL GLY SEQRES 62 A 889 LYS GLY GLY HIS SER GLY SER LYS PHE MET CYS CYS HIS SEQRES 63 A 889 ASP THR LYS CYS SER SER THR GLY LEU VAL ALA ALA ALA SEQRES 64 A 889 PRO HIS LEU ASP ARG VAL THR GLY TYR ASN GLN ALA ASP SEQRES 65 A 889 SER ASP LYS ILE PHE ASP ASP GLY ALA PRO GLU GLY LEU SEQRES 66 A 889 VAL PRO ARG GLY SER GLY PRO PHE GLU ASP ASP ASP ASP SEQRES 67 A 889 LYS ALA GLY TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 68 A 889 GLY SER GLY GLY GLY SER GLY GLY GLY SER TRP SER HIS SEQRES 69 A 889 PRO GLN PHE GLU LYS SEQRES 1 B 889 ARG SER SER ARG GLY ASP THR ARG ASN LEU ASN GLU LEU SEQRES 2 B 889 LYS MET GLU CYS PRO HIS THR ILE GLY LEU GLY GLN GLY SEQRES 3 B 889 LEU VAL ILE GLY SER ILE GLU LEU PRO PRO VAL PRO LEU SEQRES 4 B 889 ILE GLN VAL GLU SER LEU LYS LEU GLU SER SER CYS ASN SEQRES 5 B 889 PHE ASP LEU HIS THR SER THR SER SER GLN GLN ALA PHE SEQRES 6 B 889 THR LYS TRP THR TRP GLU VAL LYS SER ASP LEU ALA GLU SEQRES 7 B 889 ASN THR GLN ALA SER SER THR SER PHE GLN THR LYS SER SEQRES 8 B 889 SER GLU VAL ASN LEU ARG GLY LEU CYS LEU VAL PRO PRO SEQRES 9 B 889 LEU VAL ILE GLU THR ALA ALA ARG THR ARG LYS THR ILE SEQRES 10 B 889 ALA CYS PHE ASP LEU SER CYS ASN GLN THR THR CYS GLN SEQRES 11 B 889 PRO THR VAL PHE LEU MET GLY PRO ILE GLN THR CYS ILE SEQRES 12 B 889 THR THR LYS SER CYS LEU LEU GLY LEU GLY ASP GLN ARG SEQRES 13 B 889 ILE GLN VAL ASN TYR GLU LYS THR TYR CYS VAL SER GLY SEQRES 14 B 889 GLN LEU ILE GLU GLY ILE CYS PHE ASN PRO VAL HIS THR SEQRES 15 B 889 MET ALA LEU SER GLN PRO SER HIS THR TYR ASP ILE VAL SEQRES 16 B 889 THR VAL MET VAL ARG CYS PHE LEU ILE VAL LYS LYS VAL SEQRES 17 B 889 THR THR GLY ASP SER MET LYS ILE GLU LYS SER PHE GLU SEQRES 18 B 889 THR LEU VAL GLN LYS THR GLY CYS THR ASP ASN GLY PHE SEQRES 19 B 889 GLN GLY TYR TYR VAL CYS LEU ILE GLY SER SER SER GLU SEQRES 20 B 889 PRO LEU TYR ILE PRO THR LEU ASP ASP TYR ARG SER ALA SEQRES 21 B 889 GLU VAL LEU SER ARG MET ALA PHE ALA PRO HIS GLY GLU SEQRES 22 B 889 ASP HIS ASP ILE GLU LYS ASN ALA ILE SER ALA MET ARG SEQRES 23 B 889 ILE VAL GLY LYS VAL THR GLY LYS ALA PRO SER THR GLU SEQRES 24 B 889 SER SER ASP THR VAL GLN GLY ILE ALA PHE SER GLY ASN SEQRES 25 B 889 PRO LEU TYR THR SER THR GLY VAL LEU THR ALA LYS ASP SEQRES 26 B 889 ASP PRO VAL TYR VAL TRP ALA PRO GLY ILE MET MET GLU SEQRES 27 B 889 GLY ASN HIS SER VAL CYS ASP LYS LYS THR LEU PRO LEU SEQRES 28 B 889 THR TRP THR GLY PHE ILE PRO LEU PRO GLY GLU ILE GLU SEQRES 29 B 889 GLY GLY SER GLY LEU VAL PRO ARG GLY SER GLY GLY GLY SEQRES 30 B 889 SER GLY GLY GLY SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 31 B 889 GLY GLY GLY THR GLY GLY GLY THR LEU VAL PRO ARG GLY SEQRES 32 B 889 SER GLY THR GLY GLY GLU THR GLN ASN LEU ASN SER GLY SEQRES 33 B 889 TRP THR ASP THR ALA HIS GLY SER GLY VAL ILE PRO MET SEQRES 34 B 889 ARG THR ASP LEU GLU LEU ASP PHE SER LEU PRO SER SER SEQRES 35 B 889 ALA SER TYR THR TYR ARG ARG GLN LEU GLN ASN PRO ALA SEQRES 36 B 889 ASN GLU GLN GLU LYS ILE PRO PHE HIS LEU GLN ILE SER SEQRES 37 B 889 LYS GLN VAL ILE HIS ALA GLU ILE GLN HIS LEU GLY HIS SEQRES 38 B 889 TRP MET ASP GLY THR PHE ASN LEU LYS THR ALA PHE HIS SEQRES 39 B 889 CYS TYR GLY SER CYS GLU LYS TYR ALA TYR PRO TRP GLN SEQRES 40 B 889 THR ALA GLY CYS PHE VAL GLU LYS ASP TYR GLU TYR GLU SEQRES 41 B 889 SER GLY TRP GLY CYS ASN PRO ALA ASP CYS PRO GLY VAL SEQRES 42 B 889 GLY THR GLY CYS THR ALA CYS GLY VAL TYR LEU ASP LYS SEQRES 43 B 889 LEU LYS SER VAL GLY LYS ALA PHE LYS ILE VAL SER LEU SEQRES 44 B 889 ARG TYR THR ARG LYS ALA CYS ILE GLN LEU GLY THR GLU SEQRES 45 B 889 GLN THR CYS LYS ASN VAL ASP SER ASN ASP CYS LEU VAL SEQRES 46 B 889 THR THR SER VAL LYS VAL CYS LEU ILE GLY THR VAL SER SEQRES 47 B 889 LYS PHE GLN PRO SER ASP THR LEU LEU PHE LEU GLY PRO SEQRES 48 B 889 LEU GLU GLN GLY GLY LEU ILE PHE LYS GLN TRP CYS THR SEQRES 49 B 889 THR THR CYS GLN PHE GLY ASP PRO GLY ASP ILE MET SER SEQRES 50 B 889 THR PRO VAL GLY MET LYS CYS PRO GLU LEU SER GLY SER SEQRES 51 B 889 PHE ARG LYS LYS CYS ALA PHE ALA THR THR PRO VAL CYS SEQRES 52 B 889 GLN PHE ASP GLY ASN THR ILE SER GLY TYR LYS ARG MET SEQRES 53 B 889 ILE ALA THR LYS ASP SER PHE GLN SER PHE ASN VAL THR SEQRES 54 B 889 GLU PRO HIS ILE SER ALA SER SER LEU GLU TRP ILE ASP SEQRES 55 B 889 PRO ASP SER SER LEU ARG ASP HIS ILE ASN VAL ILE VAL SEQRES 56 B 889 GLY ARG ASP LEU SER PHE GLN ASP LEU SER GLU THR PRO SEQRES 57 B 889 CYS GLN VAL ASP LEU THR THR THR SER ILE ASP GLY ALA SEQRES 58 B 889 TRP GLY SER GLY VAL GLY PHE ASN LEU ILE CYS SER VAL SEQRES 59 B 889 SER LEU THR GLU CYS SER THR PHE LEU THR SER ILE LYS SEQRES 60 B 889 ALA CYS ASP SER ALA MET CYS TYR GLY SER THR THR ALA SEQRES 61 B 889 ASN LEU VAL ARG GLY GLN ASN THR VAL HIS ILE VAL GLY SEQRES 62 B 889 LYS GLY GLY HIS SER GLY SER LYS PHE MET CYS CYS HIS SEQRES 63 B 889 ASP THR LYS CYS SER SER THR GLY LEU VAL ALA ALA ALA SEQRES 64 B 889 PRO HIS LEU ASP ARG VAL THR GLY TYR ASN GLN ALA ASP SEQRES 65 B 889 SER ASP LYS ILE PHE ASP ASP GLY ALA PRO GLU GLY LEU SEQRES 66 B 889 VAL PRO ARG GLY SER GLY PRO PHE GLU ASP ASP ASP ASP SEQRES 67 B 889 LYS ALA GLY TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 68 B 889 GLY SER GLY GLY GLY SER GLY GLY GLY SER TRP SER HIS SEQRES 69 B 889 PRO GLN PHE GLU LYS SEQRES 1 H 298 ARG SER GLN VAL GLN LEU VAL GLU SER GLY GLY GLY VAL SEQRES 2 H 298 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 H 298 SER GLY PHE THR PHE SER SER TYR ALA MET HIS TRP VAL SEQRES 4 H 298 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL SEQRES 5 H 298 THR TRP PHE ASP VAL SER LYS LYS ASP TYR ALA ASP SER SEQRES 6 H 298 VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS SEQRES 7 H 298 ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU SEQRES 8 H 298 ASP THR ALA VAL TYR TYR CYS ALA ARG ASN LEU ILE ARG SEQRES 9 H 298 TYR SER GLY SER TYR PHE PRO VAL HIS GLY MET ASP VAL SEQRES 10 H 298 TRP GLY GLN GLY THR THR VAL THR VAL SER SER GLY THR SEQRES 11 H 298 GLY GLY SER GLY GLY GLY GLY SER GLY GLY GLY GLY SER SEQRES 12 H 298 GLY GLY GLY ALA SER ASP ILE VAL MET THR GLN SER PRO SEQRES 13 H 298 LEU SER LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SEQRES 14 H 298 SER CYS ARG SER SER GLN SER LEU LEU HIS THR TYR GLY SEQRES 15 H 298 TYR ASN CYS LEU ASP TRP TYR LEU GLN ARG PRO GLY GLN SEQRES 16 H 298 SER PRO GLN LEU LEU ILE SER LEU GLY SER TYR ARG ALA SEQRES 17 H 298 SER GLY VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY SEQRES 18 H 298 THR ASP PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU SEQRES 19 H 298 ASP VAL GLY VAL TYR TYR CYS MET GLN ALA LEU HIS PRO SEQRES 20 H 298 PHE THR PHE GLY GLY GLY THR LYS VAL GLU ILE LYS GLY SEQRES 21 H 298 PRO PHE GLU ASP ASP ASP ASP LYS ALA GLY TRP SER HIS SEQRES 22 H 298 PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER SEQRES 23 H 298 GLY GLY GLY SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 L 298 ARG SER GLN VAL GLN LEU VAL GLU SER GLY GLY GLY VAL SEQRES 2 L 298 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SEQRES 3 L 298 SER GLY PHE THR PHE SER SER TYR ALA MET HIS TRP VAL SEQRES 4 L 298 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL SEQRES 5 L 298 THR TRP PHE ASP VAL SER LYS LYS ASP TYR ALA ASP SER SEQRES 6 L 298 VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS SEQRES 7 L 298 ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU SEQRES 8 L 298 ASP THR ALA VAL TYR TYR CYS ALA ARG ASN LEU ILE ARG SEQRES 9 L 298 TYR SER GLY SER TYR PHE PRO VAL HIS GLY MET ASP VAL SEQRES 10 L 298 TRP GLY GLN GLY THR THR VAL THR VAL SER SER GLY THR SEQRES 11 L 298 GLY GLY SER GLY GLY GLY GLY SER GLY GLY GLY GLY SER SEQRES 12 L 298 GLY GLY GLY ALA SER ASP ILE VAL MET THR GLN SER PRO SEQRES 13 L 298 LEU SER LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SEQRES 14 L 298 SER CYS ARG SER SER GLN SER LEU LEU HIS THR TYR GLY SEQRES 15 L 298 TYR ASN CYS LEU ASP TRP TYR LEU GLN ARG PRO GLY GLN SEQRES 16 L 298 SER PRO GLN LEU LEU ILE SER LEU GLY SER TYR ARG ALA SEQRES 17 L 298 SER GLY VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY SEQRES 18 L 298 THR ASP PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU SEQRES 19 L 298 ASP VAL GLY VAL TYR TYR CYS MET GLN ALA LEU HIS PRO SEQRES 20 L 298 PHE THR PHE GLY GLY GLY THR LYS VAL GLU ILE LYS GLY SEQRES 21 L 298 PRO PHE GLU ASP ASP ASP ASP LYS ALA GLY TRP SER HIS SEQRES 22 L 298 PRO GLN PHE GLU LYS GLY GLY GLY SER GLY GLY GLY SER SEQRES 23 L 298 GLY GLY GLY SER TRP SER HIS PRO GLN PHE GLU LYS HET GOL A1001 6 HET NAG C 1 14 HET NAG C 2 14 HET BMA C 3 11 HET MAN C 4 11 HET MAN C 5 11 HET MAN C 6 11 HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HETNAM GOL GLYCEROL HETNAM NAG N-ACETYL-D-GLUCOSAMINE HETNAM BMA BETA-D-MANNOSE HETNAM MAN ALPHA-D-MANNOSE HETSYN GOL GLYCERIN; PROPANE-1,2,3-TRIOL FORMUL 5 GOL C3 H8 O3 FORMUL 6 NAG 6(C8 H15 N O6) FORMUL 6 BMA C6 H12 O6 FORMUL 6 MAN 3(C6 H12 O6) FORMUL 9 HOH *26(H2 O) HELIX 1 AA1 ILE A 57 VAL A 59 5 3 HELIX 2 AA2 THR A 74 SER A 77 5 4 HELIX 3 AA3 THR A 126 ARG A 131 1 6 HELIX 4 AA4 GLN A 157 THR A 162 1 6 HELIX 5 AA5 LYS A 232 VAL A 241 1 10 HELIX 6 AA6 ASP A 273 ALA A 286 1 14 HELIX 7 AA7 TYR B 754 ALA B 759 5 6 HELIX 8 AA8 PRO B 861 GLY B 865 5 5 HELIX 9 AA9 SER B 921 ALA B 928 1 8 HELIX 10 AB1 THR B 929 PHE B 933 5 5 HELIX 11 AB2 SER B 970 SER B 975 1 6 HELIX 12 AB3 ARG H 83 THR H 87 5 5 HELIX 13 AB4 GLU L 79 VAL L 83 5 5 SHEET 1 AA1 4 LEU A 27 CYS A 34 0 SHEET 2 AA1 4 GLN A 172 LYS A 180 1 O ASN A 177 N MET A 32 SHEET 3 AA1 4 SER A 164 LEU A 169 -1 N LEU A 169 O GLN A 172 SHEET 4 AA1 4 LEU A 64 GLU A 65 -1 N GLU A 65 O GLY A 168 SHEET 1 AA2 5 LEU A 44 GLU A 50 0 SHEET 2 AA2 5 VAL A 54 PRO A 55 0 SHEET 3 AA2 5 ILE A 134 CYS A 141 0 SHEET 4 AA2 5 THR A 145 PRO A 155 -1 O MET A 153 N ILE A 134 SHEET 5 AA2 5 SER A 262 SER A 263 -1 O SER A 263 N LEU A 44 SHEET 1 AA3 5 PHE A 104 ARG A 114 0 SHEET 2 AA3 5 GLN A 79 VAL A 89 -1 N PHE A 82 O VAL A 111 SHEET 3 AA3 5 TYR A 346 TRP A 348 1 O TYR A 346 N THR A 83 SHEET 4 AA3 5 THR A 335 LEU A 338 -1 N GLY A 336 O VAL A 347 SHEET 5 AA3 5 THR A 365 PRO A 367 -1 O LEU A 366 N VAL A 337 SHEET 1 AA4 6 GLN A 187 ILE A 189 0 SHEET 2 AA4 6 ILE A 192 PRO A 196 -1 O ILE A 192 N ILE A 189 SHEET 3 AA4 6 THR A 369 ILE A 380 -1 O GLU A 379 N ASN A 195 SHEET 4 AA4 6 ILE A 211 VAL A 222 -1 N VAL A 212 O LEU A 376 SHEET 5 AA4 6 GLY A 253 ILE A 259 -1 O TYR A 254 N ILE A 221 SHEET 6 AA4 6 LEU A 266 ILE A 268 -1 O ILE A 268 N TYR A 255 SHEET 1 AA517 SER A 300 GLY A 310 0 SHEET 2 AA517 VAL A 321 SER A 327 -1 O VAL A 321 N GLY A 310 SHEET 3 AA517 ILE A 352 MET A 354 -1 O MET A 353 N ILE A 324 SHEET 4 AA517 VAL B 676 PRO B 678 0 SHEET 5 AA517 SER B 694 GLN B 702 1 O GLN B 700 N ILE B 677 SHEET 6 AA517 LYS B 710 HIS B 744 -1 O LEU B 715 N TYR B 697 SHEET 7 AA517 CYS B 761 TYR B 767 0 SHEET 8 AA517 THR B 788 LEU B 819 -1 O CYS B 790 N LYS B 765 SHEET 9 AA517 GLU B 822 VAL B 828 -1 O THR B 824 N ILE B 817 SHEET 10 AA517 THR B 855 PHE B 858 -1 O LEU B 856 N PHE B 804 SHEET 11 AA517 GLY B 866 PHE B 869 -1 O LEU B 867 N LEU B 857 SHEET 12 AA517 MET B 886 SER B 887 -1 O SER B 887 N HIS B 731 SHEET 13 AA517 MET B 892 LYS B 893 -1 O LYS B 893 N MET B 886 SHEET 14 AA517 GLN B 934 PHE B 936 -1 O GLN B 934 N ILE B 868 SHEET 15 AA517 THR B 939 ILE B 943 0 SHEET 16 AA517 SER B 947 ILE B 951 -1 O GLU B 949 N HIS B 942 SHEET 17 AA517 LYS B1085 ASP B1088 1 O ILE B1086 N SER B 694 SHEET 1 AA6 6 THR B 670 ALA B 671 0 SHEET 2 AA6 6 GLN B 980 GLY B 990 0 SHEET 3 AA6 6 PHE B 998 CYS B1019 -1 O THR B1007 N GLN B 980 SHEET 4 AA6 6 MET B1023 GLY B1043 -1 O ASN B1037 N VAL B1004 SHEET 5 AA6 6 MET B1053 HIS B1056 -1 O CYS B1055 N LYS B1017 SHEET 6 AA6 6 LYS B1059 CYS B1060 -1 O LYS B1059 N HIS B1056 SHEET 1 AA7 4 LEU B 683 PRO B 690 0 SHEET 2 AA7 4 ARG B 958 VAL B 965 -1 O VAL B 965 N LEU B 683 SHEET 3 AA7 4 VAL B 839 VAL B 847 -1 N CYS B 842 O ASN B 962 SHEET 4 AA7 4 LEU B 834 VAL B 835 -1 N LEU B 834 O VAL B 841 SHEET 1 AA8 2 SER B 900 ALA B 906 0 SHEET 2 AA8 2 THR B 910 ASP B 916 -1 O VAL B 912 N LYS B 904 SHEET 1 AA9 4 GLN H 3 SER H 7 0 SHEET 2 AA9 4 SER H 17 SER H 25 -1 O ALA H 23 N VAL H 5 SHEET 3 AA9 4 THR H 77 ASN H 82A-1 O LEU H 78 N CYS H 22 SHEET 4 AA9 4 PHE H 67 THR H 68 -1 N THR H 68 O GLN H 81 SHEET 1 AB1 6 VAL H 11 VAL H 12 0 SHEET 2 AB1 6 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB1 6 ALA H 88 LEU H 96 -1 N TYR H 90 O THR H 107 SHEET 4 AB1 6 TYR H 32 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AB1 6 GLU H 46 TRP H 52 -1 O VAL H 48 N TRP H 36 SHEET 6 AB1 6 LYS H 56 TYR H 59 -1 O ASP H 58 N VAL H 50 SHEET 1 AB2 4 MET L 4 GLN L 6 0 SHEET 2 AB2 4 ALA L 19 SER L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AB2 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AB2 4 PHE L 62 SER L 67 -1 N SER L 63 O LYS L 74 SHEET 1 AB3 6 SER L 10 PRO L 12 0 SHEET 2 AB3 6 THR L 101 GLU L 104 1 O LYS L 102 N LEU L 11 SHEET 3 AB3 6 GLY L 84 GLN L 90 -1 N TYR L 86 O THR L 101 SHEET 4 AB3 6 LEU L 33 GLN L 38 -1 N TYR L 36 O TYR L 87 SHEET 5 AB3 6 PRO L 44 SER L 49 -1 O ILE L 48 N TRP L 35 SHEET 6 AB3 6 TYR L 53 ARG L 54 -1 O TYR L 53 N SER L 49 SSBOND 1 CYS A 34 CYS A 159 1555 1555 2.03 SSBOND 2 CYS A 68 CYS A 165 1555 1555 2.03 SSBOND 3 CYS A 117 CYS A 136 1555 1555 2.03 SSBOND 4 CYS A 141 CYS A 146 1555 1555 2.03 SSBOND 5 CYS A 183 CYS A 193 1555 1555 2.03 SSBOND 6 CYS A 218 CYS A 257 1555 1555 2.03 SSBOND 7 CYS A 246 CYS A 361 1555 1555 2.03 SSBOND 8 CYS B 745 CYS B 780 1555 1555 2.04 SSBOND 9 CYS B 749 CYS B 787 1555 1555 2.03 SSBOND 10 CYS B 761 CYS B 894 1555 1555 2.02 SSBOND 11 CYS B 775 CYS B 905 1555 1555 2.03 SSBOND 12 CYS B 790 CYS B 913 1555 1555 2.03 SSBOND 13 CYS B 816 CYS B 825 1555 1555 2.03 SSBOND 14 CYS B 833 CYS B 842 1555 1555 2.03 SSBOND 15 CYS B 873 CYS B 877 1555 1555 2.03 SSBOND 16 CYS B 979 CYS B 1009 1555 1555 2.03 SSBOND 17 CYS B 1002 CYS B 1054 1555 1555 2.02 SSBOND 18 CYS B 1019 CYS B 1024 1555 1555 2.03 SSBOND 19 CYS B 1055 CYS B 1060 1555 1555 2.03 SSBOND 20 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 21 CYS L 23 CYS L 88 1555 1555 2.03 LINK ND2 ASN A 142 C1 NAG D 1 1555 1555 1.45 LINK ND2 ASN A 357 C1 NAG C 1 1555 1555 1.44 LINK ND2 ASN B 937 C1 NAG E 1 1555 1555 1.45 LINK O4 NAG C 1 C1 NAG C 2 1555 1555 1.44 LINK O4 NAG C 2 C1 BMA C 3 1555 1555 1.45 LINK O3 BMA C 3 C1 MAN C 4 1555 1555 1.44 LINK O6 BMA C 3 C1 MAN C 6 1555 1555 1.44 LINK O2 MAN C 4 C1 MAN C 5 1555 1555 1.45 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.45 CISPEP 1 ILE A 268 PRO A 269 0 0.34 CISPEP 2 ALA A 312 PRO A 313 0 0.95 CRYST1 83.876 109.304 149.540 90.00 90.00 90.00 P 2 21 21 8 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.011922 0.000000 0.000000 0.00000 SCALE2 0.000000 0.009149 0.000000 0.00000 SCALE3 0.000000 0.000000 0.006687 0.00000