HEADER VIRAL PROTEIN/IMMUNE SYSTEM 16-JAN-22 7TJQ TITLE SAN27-14 BOUND TO A ANTIGENIC SITE V ON PREFUSION-STABILIZED HMPV F COMPND MOL_ID: 1; COMPND 2 MOLECULE: SAN27-14 FAB HEAVY CHAIN; COMPND 3 CHAIN: A, D, H; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: SAN27-14 FAB LIGHT CHAIN; COMPND 7 CHAIN: B, E, L; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: FUSION GLYCOPROTEIN F0; COMPND 11 CHAIN: C, F, G; COMPND 12 SYNONYM: FUSION GLYCOPROTEIN F1,FUSION GLYCOPROTEIN F2; COMPND 13 ENGINEERED: YES; COMPND 14 MUTATION: YES; COMPND 15 MOL_ID: 4; COMPND 16 MOLECULE: MPE8 FAB HEAVY CHAIN; COMPND 17 CHAIN: I, J, N; COMPND 18 ENGINEERED: YES; COMPND 19 MOL_ID: 5; COMPND 20 MOLECULE: MPE8 FAB LIGHT CHAIN; COMPND 21 CHAIN: K, M, O; COMPND 22 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HUMAN METAPNEUMOVIRUS; SOURCE 13 ORGANISM_TAXID: 162145; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 4; SOURCE 17 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 21 MOL_ID: 5; SOURCE 22 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 23 ORGANISM_TAXID: 9606; SOURCE 24 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 25 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEUTRALIZING ANTIBODIES, PREFUSION-SPECIFIC ANTIBODIES, ANTIGENIC KEYWDS 2 SITE V, HMPV F, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR C.-L.HSIEH,J.S.MCLELLAN,S.A.RUSH REVDAT 1 14-SEP-22 7TJQ 0 JRNL AUTH S.A.RUSH,C.-L.HSIEH,J.S.MCLELLAN JRNL TITL CHARACTERIZATION OF PREFUSION-F-SPECIFIC ANTIBODIES ELICITED JRNL TITL 2 BY NATURAL INFECTION WITH HUMAN METAPNEUMOVIRUS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.13 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : SERIALEM REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.130 REMARK 3 NUMBER OF PARTICLES : 93710 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 7TJQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-JAN-22. REMARK 100 THE DEPOSITION ID IS D_1000262464. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : COMPLEX OF HMPV F WITH MPE8 FAB REMARK 245 AND SAN27-14 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 3492 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 7000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ARG B 108 REMARK 465 THR B 109 REMARK 465 VAL B 110 REMARK 465 ALA B 111 REMARK 465 ALA B 112 REMARK 465 PRO B 113 REMARK 465 SER B 114 REMARK 465 VAL B 115 REMARK 465 MET C 1 REMARK 465 SER C 2 REMARK 465 TRP C 3 REMARK 465 LYS C 4 REMARK 465 VAL C 5 REMARK 465 VAL C 6 REMARK 465 ILE C 7 REMARK 465 ILE C 8 REMARK 465 PHE C 9 REMARK 465 SER C 10 REMARK 465 LEU C 11 REMARK 465 LEU C 12 REMARK 465 ILE C 13 REMARK 465 THR C 14 REMARK 465 PRO C 15 REMARK 465 GLN C 16 REMARK 465 HIS C 17 REMARK 465 GLY C 18 REMARK 465 ASP C 87 REMARK 465 GLN C 88 REMARK 465 LEU C 89 REMARK 465 ALA C 90 REMARK 465 ARG C 91 REMARK 465 GLU C 92 REMARK 465 GLU C 93 REMARK 465 GLN C 94 REMARK 465 ILE C 95 REMARK 465 GLU C 96 REMARK 465 ASN C 97 REMARK 465 PRO C 98 REMARK 465 ARG C 99 REMARK 465 ARG C 100 REMARK 465 ARG C 101 REMARK 465 ARG C 102 REMARK 465 SER C 466 REMARK 465 ILE C 467 REMARK 465 GLU C 468 REMARK 465 ASN C 469 REMARK 465 SER C 470 REMARK 465 GLN C 471 REMARK 465 ALA C 472 REMARK 465 LEU C 473 REMARK 465 VAL C 474 REMARK 465 ASP C 475 REMARK 465 GLN C 476 REMARK 465 SER C 477 REMARK 465 ASN C 478 REMARK 465 ARG C 479 REMARK 465 ILE C 480 REMARK 465 LEU C 481 REMARK 465 SER C 482 REMARK 465 SER C 483 REMARK 465 ALA C 484 REMARK 465 GLU C 485 REMARK 465 LYS C 486 REMARK 465 GLY C 487 REMARK 465 ASN C 488 REMARK 465 THR C 489 REMARK 465 GLY C 490 REMARK 465 GLY C 491 REMARK 465 GLY C 492 REMARK 465 GLY C 493 REMARK 465 SER C 494 REMARK 465 GLY C 495 REMARK 465 TYR C 496 REMARK 465 ILE C 497 REMARK 465 PRO C 498 REMARK 465 GLU C 499 REMARK 465 ALA C 500 REMARK 465 PRO C 501 REMARK 465 ARG C 502 REMARK 465 ASP C 503 REMARK 465 GLY C 504 REMARK 465 GLN C 505 REMARK 465 ALA C 506 REMARK 465 TYR C 507 REMARK 465 VAL C 508 REMARK 465 ARG C 509 REMARK 465 LYS C 510 REMARK 465 ASP C 511 REMARK 465 GLY C 512 REMARK 465 GLU C 513 REMARK 465 TRP C 514 REMARK 465 VAL C 515 REMARK 465 LEU C 516 REMARK 465 LEU C 517 REMARK 465 SER C 518 REMARK 465 THR C 519 REMARK 465 PHE C 520 REMARK 465 LEU C 521 REMARK 465 GLY C 522 REMARK 465 ARG C 523 REMARK 465 SER C 524 REMARK 465 LEU C 525 REMARK 465 GLU C 526 REMARK 465 VAL C 527 REMARK 465 LEU C 528 REMARK 465 PHE C 529 REMARK 465 GLN C 530 REMARK 465 GLY C 531 REMARK 465 PRO C 532 REMARK 465 GLY C 533 REMARK 465 HIS C 534 REMARK 465 HIS C 535 REMARK 465 HIS C 536 REMARK 465 HIS C 537 REMARK 465 HIS C 538 REMARK 465 HIS C 539 REMARK 465 HIS C 540 REMARK 465 HIS C 541 REMARK 465 SER C 542 REMARK 465 ALA C 543 REMARK 465 TRP C 544 REMARK 465 SER C 545 REMARK 465 HIS C 546 REMARK 465 PRO C 547 REMARK 465 GLN C 548 REMARK 465 PHE C 549 REMARK 465 GLU C 550 REMARK 465 LYS C 551 REMARK 465 ARG E 108 REMARK 465 THR E 109 REMARK 465 VAL E 110 REMARK 465 ALA E 111 REMARK 465 ALA E 112 REMARK 465 PRO E 113 REMARK 465 SER E 114 REMARK 465 VAL E 115 REMARK 465 MET F 1 REMARK 465 SER F 2 REMARK 465 TRP F 3 REMARK 465 LYS F 4 REMARK 465 VAL F 5 REMARK 465 VAL F 6 REMARK 465 ILE F 7 REMARK 465 ILE F 8 REMARK 465 PHE F 9 REMARK 465 SER F 10 REMARK 465 LEU F 11 REMARK 465 LEU F 12 REMARK 465 ILE F 13 REMARK 465 THR F 14 REMARK 465 PRO F 15 REMARK 465 GLN F 16 REMARK 465 HIS F 17 REMARK 465 GLY F 18 REMARK 465 ASP F 87 REMARK 465 GLN F 88 REMARK 465 LEU F 89 REMARK 465 ALA F 90 REMARK 465 ARG F 91 REMARK 465 GLU F 92 REMARK 465 GLU F 93 REMARK 465 GLN F 94 REMARK 465 ILE F 95 REMARK 465 GLU F 96 REMARK 465 ASN F 97 REMARK 465 PRO F 98 REMARK 465 ARG F 99 REMARK 465 ARG F 100 REMARK 465 ARG F 101 REMARK 465 ARG F 102 REMARK 465 SER F 466 REMARK 465 ILE F 467 REMARK 465 GLU F 468 REMARK 465 ASN F 469 REMARK 465 SER F 470 REMARK 465 GLN F 471 REMARK 465 ALA F 472 REMARK 465 LEU F 473 REMARK 465 VAL F 474 REMARK 465 ASP F 475 REMARK 465 GLN F 476 REMARK 465 SER F 477 REMARK 465 ASN F 478 REMARK 465 ARG F 479 REMARK 465 ILE F 480 REMARK 465 LEU F 481 REMARK 465 SER F 482 REMARK 465 SER F 483 REMARK 465 ALA F 484 REMARK 465 GLU F 485 REMARK 465 LYS F 486 REMARK 465 GLY F 487 REMARK 465 ASN F 488 REMARK 465 THR F 489 REMARK 465 GLY F 490 REMARK 465 GLY F 491 REMARK 465 GLY F 492 REMARK 465 GLY F 493 REMARK 465 SER F 494 REMARK 465 GLY F 495 REMARK 465 TYR F 496 REMARK 465 ILE F 497 REMARK 465 PRO F 498 REMARK 465 GLU F 499 REMARK 465 ALA F 500 REMARK 465 PRO F 501 REMARK 465 ARG F 502 REMARK 465 ASP F 503 REMARK 465 GLY F 504 REMARK 465 GLN F 505 REMARK 465 ALA F 506 REMARK 465 TYR F 507 REMARK 465 VAL F 508 REMARK 465 ARG F 509 REMARK 465 LYS F 510 REMARK 465 ASP F 511 REMARK 465 GLY F 512 REMARK 465 GLU F 513 REMARK 465 TRP F 514 REMARK 465 VAL F 515 REMARK 465 LEU F 516 REMARK 465 LEU F 517 REMARK 465 SER F 518 REMARK 465 THR F 519 REMARK 465 PHE F 520 REMARK 465 LEU F 521 REMARK 465 GLY F 522 REMARK 465 ARG F 523 REMARK 465 SER F 524 REMARK 465 LEU F 525 REMARK 465 GLU F 526 REMARK 465 VAL F 527 REMARK 465 LEU F 528 REMARK 465 PHE F 529 REMARK 465 GLN F 530 REMARK 465 GLY F 531 REMARK 465 PRO F 532 REMARK 465 GLY F 533 REMARK 465 HIS F 534 REMARK 465 HIS F 535 REMARK 465 HIS F 536 REMARK 465 HIS F 537 REMARK 465 HIS F 538 REMARK 465 HIS F 539 REMARK 465 HIS F 540 REMARK 465 HIS F 541 REMARK 465 SER F 542 REMARK 465 ALA F 543 REMARK 465 TRP F 544 REMARK 465 SER F 545 REMARK 465 HIS F 546 REMARK 465 PRO F 547 REMARK 465 GLN F 548 REMARK 465 PHE F 549 REMARK 465 GLU F 550 REMARK 465 LYS F 551 REMARK 465 MET G 1 REMARK 465 SER G 2 REMARK 465 TRP G 3 REMARK 465 LYS G 4 REMARK 465 VAL G 5 REMARK 465 VAL G 6 REMARK 465 ILE G 7 REMARK 465 ILE G 8 REMARK 465 PHE G 9 REMARK 465 SER G 10 REMARK 465 LEU G 11 REMARK 465 LEU G 12 REMARK 465 ILE G 13 REMARK 465 THR G 14 REMARK 465 PRO G 15 REMARK 465 GLN G 16 REMARK 465 HIS G 17 REMARK 465 GLY G 18 REMARK 465 ASP G 87 REMARK 465 GLN G 88 REMARK 465 LEU G 89 REMARK 465 ALA G 90 REMARK 465 ARG G 91 REMARK 465 GLU G 92 REMARK 465 GLU G 93 REMARK 465 GLN G 94 REMARK 465 ILE G 95 REMARK 465 GLU G 96 REMARK 465 ASN G 97 REMARK 465 PRO G 98 REMARK 465 ARG G 99 REMARK 465 ARG G 100 REMARK 465 ARG G 101 REMARK 465 ARG G 102 REMARK 465 SER G 466 REMARK 465 ILE G 467 REMARK 465 GLU G 468 REMARK 465 ASN G 469 REMARK 465 SER G 470 REMARK 465 GLN G 471 REMARK 465 ALA G 472 REMARK 465 LEU G 473 REMARK 465 VAL G 474 REMARK 465 ASP G 475 REMARK 465 GLN G 476 REMARK 465 SER G 477 REMARK 465 ASN G 478 REMARK 465 ARG G 479 REMARK 465 ILE G 480 REMARK 465 LEU G 481 REMARK 465 SER G 482 REMARK 465 SER G 483 REMARK 465 ALA G 484 REMARK 465 GLU G 485 REMARK 465 LYS G 486 REMARK 465 GLY G 487 REMARK 465 ASN G 488 REMARK 465 THR G 489 REMARK 465 GLY G 490 REMARK 465 GLY G 491 REMARK 465 GLY G 492 REMARK 465 GLY G 493 REMARK 465 SER G 494 REMARK 465 GLY G 495 REMARK 465 TYR G 496 REMARK 465 ILE G 497 REMARK 465 PRO G 498 REMARK 465 GLU G 499 REMARK 465 ALA G 500 REMARK 465 PRO G 501 REMARK 465 ARG G 502 REMARK 465 ASP G 503 REMARK 465 GLY G 504 REMARK 465 GLN G 505 REMARK 465 ALA G 506 REMARK 465 TYR G 507 REMARK 465 VAL G 508 REMARK 465 ARG G 509 REMARK 465 LYS G 510 REMARK 465 ASP G 511 REMARK 465 GLY G 512 REMARK 465 GLU G 513 REMARK 465 TRP G 514 REMARK 465 VAL G 515 REMARK 465 LEU G 516 REMARK 465 LEU G 517 REMARK 465 SER G 518 REMARK 465 THR G 519 REMARK 465 PHE G 520 REMARK 465 LEU G 521 REMARK 465 GLY G 522 REMARK 465 ARG G 523 REMARK 465 SER G 524 REMARK 465 LEU G 525 REMARK 465 GLU G 526 REMARK 465 VAL G 527 REMARK 465 LEU G 528 REMARK 465 PHE G 529 REMARK 465 GLN G 530 REMARK 465 GLY G 531 REMARK 465 PRO G 532 REMARK 465 GLY G 533 REMARK 465 HIS G 534 REMARK 465 HIS G 535 REMARK 465 HIS G 536 REMARK 465 HIS G 537 REMARK 465 HIS G 538 REMARK 465 HIS G 539 REMARK 465 HIS G 540 REMARK 465 HIS G 541 REMARK 465 SER G 542 REMARK 465 ALA G 543 REMARK 465 TRP G 544 REMARK 465 SER G 545 REMARK 465 HIS G 546 REMARK 465 PRO G 547 REMARK 465 GLN G 548 REMARK 465 PHE G 549 REMARK 465 GLU G 550 REMARK 465 LYS G 551 REMARK 465 ALA I 125 REMARK 465 SER I 126 REMARK 465 THR I 127 REMARK 465 LYS I 128 REMARK 465 GLY I 129 REMARK 465 PRO I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 PHE I 133 REMARK 465 PRO I 134 REMARK 465 LEU I 135 REMARK 465 ALA I 136 REMARK 465 PRO I 137 REMARK 465 SER I 138 REMARK 465 SER I 139 REMARK 465 LYS I 140 REMARK 465 SER I 141 REMARK 465 THR I 142 REMARK 465 SER I 143 REMARK 465 GLY I 144 REMARK 465 GLY I 145 REMARK 465 THR I 146 REMARK 465 ALA I 147 REMARK 465 ALA I 148 REMARK 465 LEU I 149 REMARK 465 GLY I 150 REMARK 465 CYS I 151 REMARK 465 LEU I 152 REMARK 465 VAL I 153 REMARK 465 LYS I 154 REMARK 465 ASP I 155 REMARK 465 TYR I 156 REMARK 465 PHE I 157 REMARK 465 PRO I 158 REMARK 465 GLU I 159 REMARK 465 PRO I 160 REMARK 465 VAL I 161 REMARK 465 THR I 162 REMARK 465 VAL I 163 REMARK 465 SER I 164 REMARK 465 TRP I 165 REMARK 465 ASN I 166 REMARK 465 SER I 167 REMARK 465 GLY I 168 REMARK 465 ALA I 169 REMARK 465 LEU I 170 REMARK 465 THR I 171 REMARK 465 SER I 172 REMARK 465 GLY I 173 REMARK 465 VAL I 174 REMARK 465 HIS I 175 REMARK 465 THR I 176 REMARK 465 PHE I 177 REMARK 465 PRO I 178 REMARK 465 ALA I 179 REMARK 465 VAL I 180 REMARK 465 LEU I 181 REMARK 465 GLN I 182 REMARK 465 SER I 183 REMARK 465 SER I 184 REMARK 465 GLY I 185 REMARK 465 LEU I 186 REMARK 465 TYR I 187 REMARK 465 SER I 188 REMARK 465 LEU I 189 REMARK 465 SER I 190 REMARK 465 SER I 191 REMARK 465 VAL I 192 REMARK 465 VAL I 193 REMARK 465 THR I 194 REMARK 465 VAL I 195 REMARK 465 PRO I 196 REMARK 465 SER I 197 REMARK 465 SER I 198 REMARK 465 SER I 199 REMARK 465 LEU I 200 REMARK 465 GLY I 201 REMARK 465 THR I 202 REMARK 465 GLN I 203 REMARK 465 THR I 204 REMARK 465 TYR I 205 REMARK 465 ILE I 206 REMARK 465 CYS I 207 REMARK 465 ASN I 208 REMARK 465 VAL I 209 REMARK 465 ASN I 210 REMARK 465 HIS I 211 REMARK 465 LYS I 212 REMARK 465 PRO I 213 REMARK 465 SER I 214 REMARK 465 ASN I 215 REMARK 465 THR I 216 REMARK 465 LYS I 217 REMARK 465 VAL I 218 REMARK 465 ASP I 219 REMARK 465 LYS I 220 REMARK 465 LYS I 221 REMARK 465 VAL I 222 REMARK 465 GLU I 223 REMARK 465 PRO I 224 REMARK 465 LYS I 225 REMARK 465 SER I 226 REMARK 465 CYS I 227 REMARK 465 ASP I 228 REMARK 465 GLN I 229 REMARK 465 SER I 230 REMARK 465 ALA J 125 REMARK 465 SER J 126 REMARK 465 THR J 127 REMARK 465 LYS J 128 REMARK 465 GLY J 129 REMARK 465 PRO J 130 REMARK 465 SER J 131 REMARK 465 VAL J 132 REMARK 465 PHE J 133 REMARK 465 PRO J 134 REMARK 465 LEU J 135 REMARK 465 ALA J 136 REMARK 465 PRO J 137 REMARK 465 SER J 138 REMARK 465 SER J 139 REMARK 465 LYS J 140 REMARK 465 SER J 141 REMARK 465 THR J 142 REMARK 465 SER J 143 REMARK 465 GLY J 144 REMARK 465 GLY J 145 REMARK 465 THR J 146 REMARK 465 ALA J 147 REMARK 465 ALA J 148 REMARK 465 LEU J 149 REMARK 465 GLY J 150 REMARK 465 CYS J 151 REMARK 465 LEU J 152 REMARK 465 VAL J 153 REMARK 465 LYS J 154 REMARK 465 ASP J 155 REMARK 465 TYR J 156 REMARK 465 PHE J 157 REMARK 465 PRO J 158 REMARK 465 GLU J 159 REMARK 465 PRO J 160 REMARK 465 VAL J 161 REMARK 465 THR J 162 REMARK 465 VAL J 163 REMARK 465 SER J 164 REMARK 465 TRP J 165 REMARK 465 ASN J 166 REMARK 465 SER J 167 REMARK 465 GLY J 168 REMARK 465 ALA J 169 REMARK 465 LEU J 170 REMARK 465 THR J 171 REMARK 465 SER J 172 REMARK 465 GLY J 173 REMARK 465 VAL J 174 REMARK 465 HIS J 175 REMARK 465 THR J 176 REMARK 465 PHE J 177 REMARK 465 PRO J 178 REMARK 465 ALA J 179 REMARK 465 VAL J 180 REMARK 465 LEU J 181 REMARK 465 GLN J 182 REMARK 465 SER J 183 REMARK 465 SER J 184 REMARK 465 GLY J 185 REMARK 465 LEU J 186 REMARK 465 TYR J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 SER J 190 REMARK 465 SER J 191 REMARK 465 VAL J 192 REMARK 465 VAL J 193 REMARK 465 THR J 194 REMARK 465 VAL J 195 REMARK 465 PRO J 196 REMARK 465 SER J 197 REMARK 465 SER J 198 REMARK 465 SER J 199 REMARK 465 LEU J 200 REMARK 465 GLY J 201 REMARK 465 THR J 202 REMARK 465 GLN J 203 REMARK 465 THR J 204 REMARK 465 TYR J 205 REMARK 465 ILE J 206 REMARK 465 CYS J 207 REMARK 465 ASN J 208 REMARK 465 VAL J 209 REMARK 465 ASN J 210 REMARK 465 HIS J 211 REMARK 465 LYS J 212 REMARK 465 PRO J 213 REMARK 465 SER J 214 REMARK 465 ASN J 215 REMARK 465 THR J 216 REMARK 465 LYS J 217 REMARK 465 VAL J 218 REMARK 465 ASP J 219 REMARK 465 LYS J 220 REMARK 465 LYS J 221 REMARK 465 VAL J 222 REMARK 465 GLU J 223 REMARK 465 PRO J 224 REMARK 465 LYS J 225 REMARK 465 SER J 226 REMARK 465 CYS J 227 REMARK 465 ASP J 228 REMARK 465 GLN J 229 REMARK 465 SER J 230 REMARK 465 LEU K 110 REMARK 465 GLY K 111 REMARK 465 GLN K 112 REMARK 465 PRO K 113 REMARK 465 LYS K 114 REMARK 465 ALA K 115 REMARK 465 ALA K 116 REMARK 465 PRO K 117 REMARK 465 SER K 118 REMARK 465 VAL K 119 REMARK 465 THR K 120 REMARK 465 LEU K 121 REMARK 465 PHE K 122 REMARK 465 PRO K 123 REMARK 465 PRO K 124 REMARK 465 SER K 125 REMARK 465 SER K 126 REMARK 465 GLU K 127 REMARK 465 GLU K 128 REMARK 465 LEU K 129 REMARK 465 GLN K 130 REMARK 465 ALA K 131 REMARK 465 ASN K 132 REMARK 465 LYS K 133 REMARK 465 ALA K 134 REMARK 465 THR K 135 REMARK 465 LEU K 136 REMARK 465 VAL K 137 REMARK 465 CYS K 138 REMARK 465 LEU K 139 REMARK 465 ILE K 140 REMARK 465 SER K 141 REMARK 465 ASP K 142 REMARK 465 PHE K 143 REMARK 465 TYR K 144 REMARK 465 PRO K 145 REMARK 465 GLY K 146 REMARK 465 ALA K 147 REMARK 465 VAL K 148 REMARK 465 THR K 149 REMARK 465 VAL K 150 REMARK 465 ALA K 151 REMARK 465 TRP K 152 REMARK 465 LYS K 153 REMARK 465 ALA K 154 REMARK 465 ASP K 155 REMARK 465 SER K 156 REMARK 465 SER K 157 REMARK 465 PRO K 158 REMARK 465 VAL K 159 REMARK 465 LYS K 160 REMARK 465 ALA K 161 REMARK 465 GLY K 162 REMARK 465 VAL K 163 REMARK 465 GLU K 164 REMARK 465 THR K 165 REMARK 465 THR K 166 REMARK 465 THR K 167 REMARK 465 PRO K 168 REMARK 465 SER K 169 REMARK 465 LYS K 170 REMARK 465 GLN K 171 REMARK 465 SER K 172 REMARK 465 ASN K 173 REMARK 465 ASN K 174 REMARK 465 LYS K 175 REMARK 465 TYR K 176 REMARK 465 ALA K 177 REMARK 465 ALA K 178 REMARK 465 SER K 179 REMARK 465 SER K 180 REMARK 465 TYR K 181 REMARK 465 LEU K 182 REMARK 465 SER K 183 REMARK 465 LEU K 184 REMARK 465 THR K 185 REMARK 465 PRO K 186 REMARK 465 GLU K 187 REMARK 465 GLN K 188 REMARK 465 TRP K 189 REMARK 465 LYS K 190 REMARK 465 SER K 191 REMARK 465 HIS K 192 REMARK 465 LYS K 193 REMARK 465 SER K 194 REMARK 465 TYR K 195 REMARK 465 SER K 196 REMARK 465 CYS K 197 REMARK 465 GLN K 198 REMARK 465 VAL K 199 REMARK 465 THR K 200 REMARK 465 HIS K 201 REMARK 465 GLU K 202 REMARK 465 GLY K 203 REMARK 465 SER K 204 REMARK 465 THR K 205 REMARK 465 VAL K 206 REMARK 465 GLU K 207 REMARK 465 LYS K 208 REMARK 465 THR K 209 REMARK 465 VAL K 210 REMARK 465 ALA K 211 REMARK 465 PRO K 212 REMARK 465 THR K 213 REMARK 465 GLU K 214 REMARK 465 CYS K 215 REMARK 465 SER K 216 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 LEU M 110 REMARK 465 GLY M 111 REMARK 465 GLN M 112 REMARK 465 PRO M 113 REMARK 465 LYS M 114 REMARK 465 ALA M 115 REMARK 465 ALA M 116 REMARK 465 PRO M 117 REMARK 465 SER M 118 REMARK 465 VAL M 119 REMARK 465 THR M 120 REMARK 465 LEU M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 PRO M 124 REMARK 465 SER M 125 REMARK 465 SER M 126 REMARK 465 GLU M 127 REMARK 465 GLU M 128 REMARK 465 LEU M 129 REMARK 465 GLN M 130 REMARK 465 ALA M 131 REMARK 465 ASN M 132 REMARK 465 LYS M 133 REMARK 465 ALA M 134 REMARK 465 THR M 135 REMARK 465 LEU M 136 REMARK 465 VAL M 137 REMARK 465 CYS M 138 REMARK 465 LEU M 139 REMARK 465 ILE M 140 REMARK 465 SER M 141 REMARK 465 ASP M 142 REMARK 465 PHE M 143 REMARK 465 TYR M 144 REMARK 465 PRO M 145 REMARK 465 GLY M 146 REMARK 465 ALA M 147 REMARK 465 VAL M 148 REMARK 465 THR M 149 REMARK 465 VAL M 150 REMARK 465 ALA M 151 REMARK 465 TRP M 152 REMARK 465 LYS M 153 REMARK 465 ALA M 154 REMARK 465 ASP M 155 REMARK 465 SER M 156 REMARK 465 SER M 157 REMARK 465 PRO M 158 REMARK 465 VAL M 159 REMARK 465 LYS M 160 REMARK 465 ALA M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 GLU M 164 REMARK 465 THR M 165 REMARK 465 THR M 166 REMARK 465 THR M 167 REMARK 465 PRO M 168 REMARK 465 SER M 169 REMARK 465 LYS M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 ASN M 173 REMARK 465 ASN M 174 REMARK 465 LYS M 175 REMARK 465 TYR M 176 REMARK 465 ALA M 177 REMARK 465 ALA M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 TYR M 181 REMARK 465 LEU M 182 REMARK 465 SER M 183 REMARK 465 LEU M 184 REMARK 465 THR M 185 REMARK 465 PRO M 186 REMARK 465 GLU M 187 REMARK 465 GLN M 188 REMARK 465 TRP M 189 REMARK 465 LYS M 190 REMARK 465 SER M 191 REMARK 465 HIS M 192 REMARK 465 LYS M 193 REMARK 465 SER M 194 REMARK 465 TYR M 195 REMARK 465 SER M 196 REMARK 465 CYS M 197 REMARK 465 GLN M 198 REMARK 465 VAL M 199 REMARK 465 THR M 200 REMARK 465 HIS M 201 REMARK 465 GLU M 202 REMARK 465 GLY M 203 REMARK 465 SER M 204 REMARK 465 THR M 205 REMARK 465 VAL M 206 REMARK 465 GLU M 207 REMARK 465 LYS M 208 REMARK 465 THR M 209 REMARK 465 VAL M 210 REMARK 465 ALA M 211 REMARK 465 PRO M 212 REMARK 465 THR M 213 REMARK 465 GLU M 214 REMARK 465 CYS M 215 REMARK 465 SER M 216 REMARK 465 ALA N 125 REMARK 465 SER N 126 REMARK 465 THR N 127 REMARK 465 LYS N 128 REMARK 465 GLY N 129 REMARK 465 PRO N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 PHE N 133 REMARK 465 PRO N 134 REMARK 465 LEU N 135 REMARK 465 ALA N 136 REMARK 465 PRO N 137 REMARK 465 SER N 138 REMARK 465 SER N 139 REMARK 465 LYS N 140 REMARK 465 SER N 141 REMARK 465 THR N 142 REMARK 465 SER N 143 REMARK 465 GLY N 144 REMARK 465 GLY N 145 REMARK 465 THR N 146 REMARK 465 ALA N 147 REMARK 465 ALA N 148 REMARK 465 LEU N 149 REMARK 465 GLY N 150 REMARK 465 CYS N 151 REMARK 465 LEU N 152 REMARK 465 VAL N 153 REMARK 465 LYS N 154 REMARK 465 ASP N 155 REMARK 465 TYR N 156 REMARK 465 PHE N 157 REMARK 465 PRO N 158 REMARK 465 GLU N 159 REMARK 465 PRO N 160 REMARK 465 VAL N 161 REMARK 465 THR N 162 REMARK 465 VAL N 163 REMARK 465 SER N 164 REMARK 465 TRP N 165 REMARK 465 ASN N 166 REMARK 465 SER N 167 REMARK 465 GLY N 168 REMARK 465 ALA N 169 REMARK 465 LEU N 170 REMARK 465 THR N 171 REMARK 465 SER N 172 REMARK 465 GLY N 173 REMARK 465 VAL N 174 REMARK 465 HIS N 175 REMARK 465 THR N 176 REMARK 465 PHE N 177 REMARK 465 PRO N 178 REMARK 465 ALA N 179 REMARK 465 VAL N 180 REMARK 465 LEU N 181 REMARK 465 GLN N 182 REMARK 465 SER N 183 REMARK 465 SER N 184 REMARK 465 GLY N 185 REMARK 465 LEU N 186 REMARK 465 TYR N 187 REMARK 465 SER N 188 REMARK 465 LEU N 189 REMARK 465 SER N 190 REMARK 465 SER N 191 REMARK 465 VAL N 192 REMARK 465 VAL N 193 REMARK 465 THR N 194 REMARK 465 VAL N 195 REMARK 465 PRO N 196 REMARK 465 SER N 197 REMARK 465 SER N 198 REMARK 465 SER N 199 REMARK 465 LEU N 200 REMARK 465 GLY N 201 REMARK 465 THR N 202 REMARK 465 GLN N 203 REMARK 465 THR N 204 REMARK 465 TYR N 205 REMARK 465 ILE N 206 REMARK 465 CYS N 207 REMARK 465 ASN N 208 REMARK 465 VAL N 209 REMARK 465 ASN N 210 REMARK 465 HIS N 211 REMARK 465 LYS N 212 REMARK 465 PRO N 213 REMARK 465 SER N 214 REMARK 465 ASN N 215 REMARK 465 THR N 216 REMARK 465 LYS N 217 REMARK 465 VAL N 218 REMARK 465 ASP N 219 REMARK 465 LYS N 220 REMARK 465 LYS N 221 REMARK 465 VAL N 222 REMARK 465 GLU N 223 REMARK 465 PRO N 224 REMARK 465 LYS N 225 REMARK 465 SER N 226 REMARK 465 CYS N 227 REMARK 465 ASP N 228 REMARK 465 GLN N 229 REMARK 465 SER N 230 REMARK 465 LEU O 110 REMARK 465 GLY O 111 REMARK 465 GLN O 112 REMARK 465 PRO O 113 REMARK 465 LYS O 114 REMARK 465 ALA O 115 REMARK 465 ALA O 116 REMARK 465 PRO O 117 REMARK 465 SER O 118 REMARK 465 VAL O 119 REMARK 465 THR O 120 REMARK 465 LEU O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 PRO O 124 REMARK 465 SER O 125 REMARK 465 SER O 126 REMARK 465 GLU O 127 REMARK 465 GLU O 128 REMARK 465 LEU O 129 REMARK 465 GLN O 130 REMARK 465 ALA O 131 REMARK 465 ASN O 132 REMARK 465 LYS O 133 REMARK 465 ALA O 134 REMARK 465 THR O 135 REMARK 465 LEU O 136 REMARK 465 VAL O 137 REMARK 465 CYS O 138 REMARK 465 LEU O 139 REMARK 465 ILE O 140 REMARK 465 SER O 141 REMARK 465 ASP O 142 REMARK 465 PHE O 143 REMARK 465 TYR O 144 REMARK 465 PRO O 145 REMARK 465 GLY O 146 REMARK 465 ALA O 147 REMARK 465 VAL O 148 REMARK 465 THR O 149 REMARK 465 VAL O 150 REMARK 465 ALA O 151 REMARK 465 TRP O 152 REMARK 465 LYS O 153 REMARK 465 ALA O 154 REMARK 465 ASP O 155 REMARK 465 SER O 156 REMARK 465 SER O 157 REMARK 465 PRO O 158 REMARK 465 VAL O 159 REMARK 465 LYS O 160 REMARK 465 ALA O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 GLU O 164 REMARK 465 THR O 165 REMARK 465 THR O 166 REMARK 465 THR O 167 REMARK 465 PRO O 168 REMARK 465 SER O 169 REMARK 465 LYS O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 ASN O 173 REMARK 465 ASN O 174 REMARK 465 LYS O 175 REMARK 465 TYR O 176 REMARK 465 ALA O 177 REMARK 465 ALA O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 TYR O 181 REMARK 465 LEU O 182 REMARK 465 SER O 183 REMARK 465 LEU O 184 REMARK 465 THR O 185 REMARK 465 PRO O 186 REMARK 465 GLU O 187 REMARK 465 GLN O 188 REMARK 465 TRP O 189 REMARK 465 LYS O 190 REMARK 465 SER O 191 REMARK 465 HIS O 192 REMARK 465 LYS O 193 REMARK 465 SER O 194 REMARK 465 TYR O 195 REMARK 465 SER O 196 REMARK 465 CYS O 197 REMARK 465 GLN O 198 REMARK 465 VAL O 199 REMARK 465 THR O 200 REMARK 465 HIS O 201 REMARK 465 GLU O 202 REMARK 465 GLY O 203 REMARK 465 SER O 204 REMARK 465 THR O 205 REMARK 465 VAL O 206 REMARK 465 GLU O 207 REMARK 465 LYS O 208 REMARK 465 THR O 209 REMARK 465 VAL O 210 REMARK 465 ALA O 211 REMARK 465 PRO O 212 REMARK 465 THR O 213 REMARK 465 GLU O 214 REMARK 465 CYS O 215 REMARK 465 SER O 216 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLU C 465 CG CD OE1 OE2 REMARK 470 GLU F 465 CG CD OE1 OE2 REMARK 470 GLU G 465 CG CD OE1 OE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 92 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 CYS D 92 CA - CB - SG ANGL. DEV. = 7.4 DEGREES REMARK 500 CYS H 92 CA - CB - SG ANGL. DEV. = 7.1 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA B 25 -167.70 -74.57 REMARK 500 ASN B 30 -128.35 49.72 REMARK 500 TYR B 49 -71.26 -110.97 REMARK 500 SER C 27 28.46 -144.90 REMARK 500 ASP C 54 42.34 -79.16 REMARK 500 ASN C 180 16.61 56.98 REMARK 500 ASP C 183 44.84 -86.22 REMARK 500 ASN C 247 40.98 -103.42 REMARK 500 LYS C 295 -83.80 -96.98 REMARK 500 LYS C 296 38.41 -86.86 REMARK 500 ASP C 306 32.37 -84.90 REMARK 500 ASP C 325 -72.24 -97.02 REMARK 500 ASN C 353 62.47 66.74 REMARK 500 ARG C 367 49.08 -101.71 REMARK 500 LEU D 4 75.66 -117.96 REMARK 500 ARG D 66 -43.77 -130.28 REMARK 500 ASN E 30 -131.11 51.28 REMARK 500 TYR E 49 -78.25 -98.70 REMARK 500 SER F 27 26.12 -146.40 REMARK 500 ASP F 54 41.02 -74.93 REMARK 500 ASN F 180 16.57 55.35 REMARK 500 ASP F 183 49.73 -84.58 REMARK 500 ASN F 247 39.78 -94.74 REMARK 500 PHE F 276 72.52 -100.97 REMARK 500 ASP F 306 30.99 -89.15 REMARK 500 TYR F 320 78.46 -116.89 REMARK 500 ASP F 325 -73.84 -80.74 REMARK 500 ASN F 353 41.59 -147.67 REMARK 500 ARG F 367 51.37 -100.98 REMARK 500 ASP F 421 19.72 55.23 REMARK 500 SER G 27 23.37 -146.99 REMARK 500 ASP G 54 40.43 -80.01 REMARK 500 ASN G 172 -57.12 -120.92 REMARK 500 ASN G 180 18.61 55.47 REMARK 500 ASN G 247 39.47 -97.73 REMARK 500 LYS G 295 -87.90 -97.28 REMARK 500 LYS G 296 42.53 -89.68 REMARK 500 TYR G 320 74.72 -115.02 REMARK 500 ASP G 325 -71.68 -80.63 REMARK 500 ASN G 353 51.94 -155.05 REMARK 500 THR H 28 96.48 -66.50 REMARK 500 ARG H 66 -36.73 -131.55 REMARK 500 SER K 26 -7.84 -59.66 REMARK 500 ASN K 28 -96.39 -118.26 REMARK 500 ASN K 54 -36.19 68.99 REMARK 500 SER K 69 89.93 -153.54 REMARK 500 SER K 92 -157.85 -142.81 REMARK 500 SER K 98 -144.61 59.64 REMARK 500 ASN L 30 -131.06 51.02 REMARK 500 TYR L 49 -68.44 -98.11 REMARK 500 REMARK 500 THIS ENTRY HAS 60 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-25929 RELATED DB: EMDB REMARK 900 SAN27-14 BOUND TO A ANTIGENIC SITE V ON PREFUSION-STABILIZED HMPV F REMARK 900 RELATED ID: EMD-25982 RELATED DB: EMDB REMARK 900 RELATED ID: 7TL0 RELATED DB: PDB DBREF 7TJQ A 1 113 PDB 7TJQ 7TJQ 1 113 DBREF 7TJQ B 1 115 PDB 7TJQ 7TJQ 1 115 DBREF 7TJQ C 1 490 UNP H6X1Z0 H6X1Z0_9MONO 1 490 DBREF 7TJQ D 1 113 PDB 7TJQ 7TJQ 1 113 DBREF 7TJQ E 1 115 PDB 7TJQ 7TJQ 1 115 DBREF 7TJQ F 1 490 UNP H6X1Z0 H6X1Z0_9MONO 1 490 DBREF 7TJQ G 1 490 UNP H6X1Z0 H6X1Z0_9MONO 1 490 DBREF 7TJQ H 1 113 PDB 7TJQ 7TJQ 1 113 DBREF 7TJQ I 1 230 PDB 7TJQ 7TJQ 1 230 DBREF 7TJQ J 1 230 PDB 7TJQ 7TJQ 1 230 DBREF 7TJQ K 3 216 PDB 7TJQ 7TJQ 3 216 DBREF 7TJQ L 1 115 PDB 7TJQ 7TJQ 1 115 DBREF 7TJQ M 3 216 PDB 7TJQ 7TJQ 3 216 DBREF 7TJQ N 1 230 PDB 7TJQ 7TJQ 1 230 DBREF 7TJQ O 3 216 PDB 7TJQ 7TJQ 3 216 SEQADV 7TJQ ARG C 100 UNP H6X1Z0 GLN 100 ENGINEERED MUTATION SEQADV 7TJQ ARG C 101 UNP H6X1Z0 SER 101 ENGINEERED MUTATION SEQADV 7TJQ CYS C 110 UNP H6X1Z0 LEU 110 ENGINEERED MUTATION SEQADV 7TJQ CYS C 127 UNP H6X1Z0 THR 127 ENGINEERED MUTATION SEQADV 7TJQ CYS C 140 UNP H6X1Z0 ALA 140 ENGINEERED MUTATION SEQADV 7TJQ CYS C 147 UNP H6X1Z0 ALA 147 ENGINEERED MUTATION SEQADV 7TJQ CYS C 153 UNP H6X1Z0 ASN 153 ENGINEERED MUTATION SEQADV 7TJQ PRO C 185 UNP H6X1Z0 ALA 185 ENGINEERED MUTATION SEQADV 7TJQ LYS C 219 UNP H6X1Z0 LEU 219 ENGINEERED MUTATION SEQADV 7TJQ ILE C 231 UNP H6X1Z0 VAL 231 ENGINEERED MUTATION SEQADV 7TJQ CYS C 322 UNP H6X1Z0 ASN 322 ENGINEERED MUTATION SEQADV 7TJQ CYS C 365 UNP H6X1Z0 THR 365 ENGINEERED MUTATION SEQADV 7TJQ GLN C 453 UNP H6X1Z0 GLU 453 ENGINEERED MUTATION SEQADV 7TJQ CYS C 463 UNP H6X1Z0 VAL 463 ENGINEERED MUTATION SEQADV 7TJQ GLY C 491 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 492 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 493 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER C 494 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 495 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR C 496 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ILE C 497 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO C 498 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU C 499 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA C 500 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO C 501 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG C 502 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP C 503 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 504 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN C 505 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA C 506 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR C 507 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL C 508 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG C 509 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS C 510 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP C 511 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 512 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU C 513 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP C 514 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL C 515 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU C 516 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU C 517 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER C 518 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ THR C 519 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE C 520 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU C 521 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 522 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG C 523 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER C 524 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU C 525 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU C 526 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL C 527 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU C 528 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE C 529 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN C 530 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 531 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO C 532 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY C 533 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 534 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 535 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 536 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 537 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 538 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 539 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 540 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 541 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER C 542 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA C 543 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP C 544 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER C 545 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS C 546 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO C 547 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN C 548 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE C 549 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU C 550 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS C 551 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG F 100 UNP H6X1Z0 GLN 100 ENGINEERED MUTATION SEQADV 7TJQ ARG F 101 UNP H6X1Z0 SER 101 ENGINEERED MUTATION SEQADV 7TJQ CYS F 110 UNP H6X1Z0 LEU 110 ENGINEERED MUTATION SEQADV 7TJQ CYS F 127 UNP H6X1Z0 THR 127 ENGINEERED MUTATION SEQADV 7TJQ CYS F 140 UNP H6X1Z0 ALA 140 ENGINEERED MUTATION SEQADV 7TJQ CYS F 147 UNP H6X1Z0 ALA 147 ENGINEERED MUTATION SEQADV 7TJQ CYS F 153 UNP H6X1Z0 ASN 153 ENGINEERED MUTATION SEQADV 7TJQ PRO F 185 UNP H6X1Z0 ALA 185 ENGINEERED MUTATION SEQADV 7TJQ LYS F 219 UNP H6X1Z0 LEU 219 ENGINEERED MUTATION SEQADV 7TJQ ILE F 231 UNP H6X1Z0 VAL 231 ENGINEERED MUTATION SEQADV 7TJQ CYS F 322 UNP H6X1Z0 ASN 322 ENGINEERED MUTATION SEQADV 7TJQ CYS F 365 UNP H6X1Z0 THR 365 ENGINEERED MUTATION SEQADV 7TJQ GLN F 453 UNP H6X1Z0 GLU 453 ENGINEERED MUTATION SEQADV 7TJQ CYS F 463 UNP H6X1Z0 VAL 463 ENGINEERED MUTATION SEQADV 7TJQ GLY F 491 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 492 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 493 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER F 494 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 495 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR F 496 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ILE F 497 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO F 498 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU F 499 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA F 500 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO F 501 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG F 502 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP F 503 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 504 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN F 505 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA F 506 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR F 507 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL F 508 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG F 509 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS F 510 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP F 511 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 512 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU F 513 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP F 514 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL F 515 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU F 516 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU F 517 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER F 518 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ THR F 519 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE F 520 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU F 521 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 522 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG F 523 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER F 524 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU F 525 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU F 526 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL F 527 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU F 528 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE F 529 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN F 530 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 531 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO F 532 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY F 533 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 534 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 535 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 536 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 537 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 538 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 539 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 540 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 541 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER F 542 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA F 543 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP F 544 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER F 545 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS F 546 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO F 547 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN F 548 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE F 549 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU F 550 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS F 551 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG G 100 UNP H6X1Z0 GLN 100 ENGINEERED MUTATION SEQADV 7TJQ ARG G 101 UNP H6X1Z0 SER 101 ENGINEERED MUTATION SEQADV 7TJQ CYS G 110 UNP H6X1Z0 LEU 110 ENGINEERED MUTATION SEQADV 7TJQ CYS G 127 UNP H6X1Z0 THR 127 ENGINEERED MUTATION SEQADV 7TJQ CYS G 140 UNP H6X1Z0 ALA 140 ENGINEERED MUTATION SEQADV 7TJQ CYS G 147 UNP H6X1Z0 ALA 147 ENGINEERED MUTATION SEQADV 7TJQ CYS G 153 UNP H6X1Z0 ASN 153 ENGINEERED MUTATION SEQADV 7TJQ PRO G 185 UNP H6X1Z0 ALA 185 ENGINEERED MUTATION SEQADV 7TJQ LYS G 219 UNP H6X1Z0 LEU 219 ENGINEERED MUTATION SEQADV 7TJQ ILE G 231 UNP H6X1Z0 VAL 231 ENGINEERED MUTATION SEQADV 7TJQ CYS G 322 UNP H6X1Z0 ASN 322 ENGINEERED MUTATION SEQADV 7TJQ CYS G 365 UNP H6X1Z0 THR 365 ENGINEERED MUTATION SEQADV 7TJQ GLN G 453 UNP H6X1Z0 GLU 453 ENGINEERED MUTATION SEQADV 7TJQ CYS G 463 UNP H6X1Z0 VAL 463 ENGINEERED MUTATION SEQADV 7TJQ GLY G 491 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 492 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 493 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER G 494 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 495 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR G 496 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ILE G 497 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO G 498 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU G 499 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA G 500 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO G 501 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG G 502 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP G 503 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 504 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN G 505 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA G 506 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TYR G 507 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL G 508 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG G 509 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS G 510 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ASP G 511 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 512 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU G 513 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP G 514 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL G 515 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU G 516 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU G 517 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER G 518 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ THR G 519 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE G 520 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU G 521 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 522 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ARG G 523 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER G 524 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU G 525 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU G 526 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ VAL G 527 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LEU G 528 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE G 529 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN G 530 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 531 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO G 532 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLY G 533 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 534 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 535 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 536 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 537 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 538 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 539 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 540 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 541 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER G 542 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ ALA G 543 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ TRP G 544 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ SER G 545 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ HIS G 546 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PRO G 547 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLN G 548 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ PHE G 549 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ GLU G 550 UNP H6X1Z0 EXPRESSION TAG SEQADV 7TJQ LYS G 551 UNP H6X1Z0 EXPRESSION TAG SEQRES 1 A 124 GLN VAL ARG LEU GLU GLN SER GLY ALA ASP VAL LYS LYS SEQRES 2 A 124 PRO GLY ALA SER VAL ARG VAL SER CYS LYS ALA SER GLY SEQRES 3 A 124 TYR THR PHE ASN GLY TYR TYR ILE HIS TRP VAL ARG GLN SEQRES 4 A 124 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 A 124 PRO TYR THR GLY GLU THR ASN TYR ALA GLN THR PHE ARG SEQRES 6 A 124 GLY ARG VAL THR LEU THR ARG ASP THR SER LEU LYS THR SEQRES 7 A 124 LEU HIS LEU ASP LEU ILE SER LEU ARG SER GLY ASP THR SEQRES 8 A 124 ALA ILE TYR TYR CYS ALA ARG GLY ASN CYS SER ILE SER SEQRES 9 A 124 GLY CYS TYR TYR SER TRP LEU ASP HIS TRP GLY GLN GLY SEQRES 10 A 124 THR LEU VAL THR VAL SER SER SEQRES 1 B 115 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 B 115 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 B 115 GLN SER ILE ASN THR TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 B 115 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLU ALA SER SEQRES 5 B 115 SER LEU GLU ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 B 115 GLY SER GLY THR GLY PHE THR LEU THR ILE SER SER LEU SEQRES 7 B 115 GLN PRO ASP ASP PHE ALA THR TYR PHE CYS GLN GLN TYR SEQRES 8 B 115 ASN THR TYR PRO ARG THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 B 115 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 1 C 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 C 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 C 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 C 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 C 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 C 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 C 551 ARG GLU LEU ARG THR VAL SER ALA ASP GLN LEU ALA ARG SEQRES 8 C 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 C 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 C 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 C 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 C 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 C 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 C 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 C 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 C 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 C 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 C 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 C 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 C 551 ARG ALA MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 C 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 C 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 C 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 C 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 C 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 C 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 C 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 C 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 C 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 C 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 C 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 C 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 C 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 C 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 C 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 C 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 C 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 C 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 C 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 C 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 C 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 C 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 C 551 PRO GLN PHE GLU LYS SEQRES 1 D 124 GLN VAL ARG LEU GLU GLN SER GLY ALA ASP VAL LYS LYS SEQRES 2 D 124 PRO GLY ALA SER VAL ARG VAL SER CYS LYS ALA SER GLY SEQRES 3 D 124 TYR THR PHE ASN GLY TYR TYR ILE HIS TRP VAL ARG GLN SEQRES 4 D 124 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 D 124 PRO TYR THR GLY GLU THR ASN TYR ALA GLN THR PHE ARG SEQRES 6 D 124 GLY ARG VAL THR LEU THR ARG ASP THR SER LEU LYS THR SEQRES 7 D 124 LEU HIS LEU ASP LEU ILE SER LEU ARG SER GLY ASP THR SEQRES 8 D 124 ALA ILE TYR TYR CYS ALA ARG GLY ASN CYS SER ILE SER SEQRES 9 D 124 GLY CYS TYR TYR SER TRP LEU ASP HIS TRP GLY GLN GLY SEQRES 10 D 124 THR LEU VAL THR VAL SER SER SEQRES 1 E 115 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 E 115 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 E 115 GLN SER ILE ASN THR TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 E 115 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLU ALA SER SEQRES 5 E 115 SER LEU GLU ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 E 115 GLY SER GLY THR GLY PHE THR LEU THR ILE SER SER LEU SEQRES 7 E 115 GLN PRO ASP ASP PHE ALA THR TYR PHE CYS GLN GLN TYR SEQRES 8 E 115 ASN THR TYR PRO ARG THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 E 115 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 1 F 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 F 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 F 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 F 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 F 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 F 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 F 551 ARG GLU LEU ARG THR VAL SER ALA ASP GLN LEU ALA ARG SEQRES 8 F 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 F 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 F 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 F 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 F 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 F 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 F 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 F 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 F 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 F 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 F 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 F 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 F 551 ARG ALA MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 F 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 F 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 F 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 F 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 F 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 F 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 F 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 F 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 F 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 F 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 F 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 F 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 F 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 F 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 F 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 F 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 F 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 F 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 F 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 F 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 F 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 F 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 F 551 PRO GLN PHE GLU LYS SEQRES 1 G 551 MET SER TRP LYS VAL VAL ILE ILE PHE SER LEU LEU ILE SEQRES 2 G 551 THR PRO GLN HIS GLY LEU LYS GLU SER TYR LEU GLU GLU SEQRES 3 G 551 SER CYS SER THR ILE THR GLU GLY TYR LEU SER VAL LEU SEQRES 4 G 551 ARG THR GLY TRP TYR THR ASN VAL PHE THR LEU GLU VAL SEQRES 5 G 551 GLY ASP VAL GLU ASN LEU THR CYS ALA ASP GLY PRO SER SEQRES 6 G 551 LEU ILE LYS THR GLU LEU ASP LEU THR LYS SER ALA LEU SEQRES 7 G 551 ARG GLU LEU ARG THR VAL SER ALA ASP GLN LEU ALA ARG SEQRES 8 G 551 GLU GLU GLN ILE GLU ASN PRO ARG ARG ARG ARG PHE VAL SEQRES 9 G 551 LEU GLY ALA ILE ALA CYS GLY VAL ALA THR ALA ALA ALA SEQRES 10 G 551 VAL THR ALA GLY VAL ALA ILE ALA LYS CYS ILE ARG LEU SEQRES 11 G 551 GLU SER GLU VAL THR ALA ILE LYS ASN CYS LEU LYS LYS SEQRES 12 G 551 THR ASN GLU CYS VAL SER THR LEU GLY CYS GLY VAL ARG SEQRES 13 G 551 VAL LEU ALA THR ALA VAL ARG GLU LEU LYS ASP PHE VAL SEQRES 14 G 551 SER LYS ASN LEU THR ARG ALA ILE ASN LYS ASN LYS CYS SEQRES 15 G 551 ASP ILE PRO ASP LEU LYS MET ALA VAL SER PHE SER GLN SEQRES 16 G 551 PHE ASN ARG ARG PHE LEU ASN VAL VAL ARG GLN PHE SER SEQRES 17 G 551 ASP ASN ALA GLY ILE THR PRO ALA ILE SER LYS ASP LEU SEQRES 18 G 551 MET THR ASP ALA GLU LEU ALA ARG ALA ILE SER ASN MET SEQRES 19 G 551 PRO THR SER ALA GLY GLN ILE LYS LEU MET LEU GLU ASN SEQRES 20 G 551 ARG ALA MET VAL ARG ARG LYS GLY PHE GLY ILE LEU ILE SEQRES 21 G 551 GLY VAL TYR GLY SER SER VAL ILE TYR MET VAL GLN LEU SEQRES 22 G 551 PRO ILE PHE GLY VAL ILE ASP THR PRO CYS TRP ILE VAL SEQRES 23 G 551 LYS ALA ALA PRO SER CYS SER GLU LYS LYS GLY ASN TYR SEQRES 24 G 551 ALA CYS LEU LEU ARG GLU ASP GLN GLY TRP TYR CYS GLN SEQRES 25 G 551 ASN ALA GLY SER THR VAL TYR TYR PRO CYS GLU LYS ASP SEQRES 26 G 551 CYS GLU THR ARG GLY ASP HIS VAL PHE CYS ASP THR ALA SEQRES 27 G 551 ALA GLY ILE ASN VAL ALA GLU GLN SER LYS GLU CYS ASN SEQRES 28 G 551 ILE ASN ILE SER THR THR ASN TYR PRO CYS LYS VAL SER SEQRES 29 G 551 CYS GLY ARG HIS PRO ILE SER MET VAL ALA LEU SER PRO SEQRES 30 G 551 LEU GLY ALA LEU VAL ALA CYS TYR LYS GLY VAL SER CYS SEQRES 31 G 551 SER ILE GLY SER ASN ARG VAL GLY ILE ILE LYS GLN LEU SEQRES 32 G 551 ASN LYS GLY CYS SER TYR ILE THR ASN GLN ASP ALA ASP SEQRES 33 G 551 THR VAL THR ILE ASP ASN THR VAL TYR GLN LEU SER LYS SEQRES 34 G 551 VAL GLU GLY GLU GLN HIS VAL ILE LYS GLY ARG PRO VAL SEQRES 35 G 551 SER SER SER PHE ASP PRO VAL LYS PHE PRO GLN ASP GLN SEQRES 36 G 551 PHE ASN VAL ALA LEU ASP GLN CYS PHE GLU SER ILE GLU SEQRES 37 G 551 ASN SER GLN ALA LEU VAL ASP GLN SER ASN ARG ILE LEU SEQRES 38 G 551 SER SER ALA GLU LYS GLY ASN THR GLY GLY GLY GLY SER SEQRES 39 G 551 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 40 G 551 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 41 G 551 LEU GLY ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY SEQRES 42 G 551 HIS HIS HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS SEQRES 43 G 551 PRO GLN PHE GLU LYS SEQRES 1 H 124 GLN VAL ARG LEU GLU GLN SER GLY ALA ASP VAL LYS LYS SEQRES 2 H 124 PRO GLY ALA SER VAL ARG VAL SER CYS LYS ALA SER GLY SEQRES 3 H 124 TYR THR PHE ASN GLY TYR TYR ILE HIS TRP VAL ARG GLN SEQRES 4 H 124 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 H 124 PRO TYR THR GLY GLU THR ASN TYR ALA GLN THR PHE ARG SEQRES 6 H 124 GLY ARG VAL THR LEU THR ARG ASP THR SER LEU LYS THR SEQRES 7 H 124 LEU HIS LEU ASP LEU ILE SER LEU ARG SER GLY ASP THR SEQRES 8 H 124 ALA ILE TYR TYR CYS ALA ARG GLY ASN CYS SER ILE SER SEQRES 9 H 124 GLY CYS TYR TYR SER TRP LEU ASP HIS TRP GLY GLN GLY SEQRES 10 H 124 THR LEU VAL THR VAL SER SER SEQRES 1 I 230 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 I 230 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 230 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 I 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 I 230 ALA SER SER SER TYR SER ASP TYR ALA ASP SER ALA LYS SEQRES 6 I 230 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS THR SER SEQRES 7 I 230 LEU PHE LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 I 230 ALA ILE TYR PHE CYS ALA ARG ALA ARG ALA THR GLY TYR SEQRES 9 I 230 SER SER ILE THR PRO TYR PHE ASP ILE TRP GLY GLN GLY SEQRES 10 I 230 THR LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 I 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 I 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 I 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 I 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 I 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 I 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 I 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 I 230 VAL GLU PRO LYS SER CYS ASP GLN SER SEQRES 1 J 230 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 J 230 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 J 230 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 J 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 J 230 ALA SER SER SER TYR SER ASP TYR ALA ASP SER ALA LYS SEQRES 6 J 230 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS THR SER SEQRES 7 J 230 LEU PHE LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 J 230 ALA ILE TYR PHE CYS ALA ARG ALA ARG ALA THR GLY TYR SEQRES 9 J 230 SER SER ILE THR PRO TYR PHE ASP ILE TRP GLY GLN GLY SEQRES 10 J 230 THR LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 J 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 J 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 J 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 J 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 J 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 J 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 J 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 J 230 VAL GLU PRO LYS SER CYS ASP GLN SER SEQRES 1 K 214 VAL VAL THR GLN PRO PRO SER VAL SER GLY ALA PRO GLY SEQRES 2 K 214 GLN ARG VAL THR ILE SER CYS THR GLY SER SER SER ASN SEQRES 3 K 214 ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN GLN LEU SEQRES 4 K 214 PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ASP ASN ASN SEQRES 5 K 214 ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER ALA SER SEQRES 6 K 214 LYS SER GLY THR SER ALA SER LEU ALA ILE THR GLY LEU SEQRES 7 K 214 GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SER TYR SEQRES 8 K 214 ASP ARG SER LEU SER GLY VAL PHE GLY THR GLY THR LYS SEQRES 9 K 214 VAL THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 K 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 K 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 K 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 K 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 K 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 K 214 THR PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS SEQRES 16 K 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 K 214 ALA PRO THR GLU CYS SER SEQRES 1 L 115 ASP ILE GLN MET THR GLN SER PRO SER THR LEU SER ALA SEQRES 2 L 115 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 115 GLN SER ILE ASN THR TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 115 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR GLU ALA SER SEQRES 5 L 115 SER LEU GLU ARG GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 115 GLY SER GLY THR GLY PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 115 GLN PRO ASP ASP PHE ALA THR TYR PHE CYS GLN GLN TYR SEQRES 8 L 115 ASN THR TYR PRO ARG THR PHE GLY GLN GLY THR LYS VAL SEQRES 9 L 115 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL SEQRES 1 M 214 VAL VAL THR GLN PRO PRO SER VAL SER GLY ALA PRO GLY SEQRES 2 M 214 GLN ARG VAL THR ILE SER CYS THR GLY SER SER SER ASN SEQRES 3 M 214 ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN GLN LEU SEQRES 4 M 214 PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ASP ASN ASN SEQRES 5 M 214 ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER ALA SER SEQRES 6 M 214 LYS SER GLY THR SER ALA SER LEU ALA ILE THR GLY LEU SEQRES 7 M 214 GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SER TYR SEQRES 8 M 214 ASP ARG SER LEU SER GLY VAL PHE GLY THR GLY THR LYS SEQRES 9 M 214 VAL THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 M 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 M 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 M 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 M 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 M 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 M 214 THR PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS SEQRES 16 M 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 M 214 ALA PRO THR GLU CYS SER SEQRES 1 N 230 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 N 230 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 N 230 PHE THR PHE SER SER TYR SER MET ASN TRP VAL ARG GLN SEQRES 4 N 230 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 N 230 ALA SER SER SER TYR SER ASP TYR ALA ASP SER ALA LYS SEQRES 6 N 230 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS THR SER SEQRES 7 N 230 LEU PHE LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 N 230 ALA ILE TYR PHE CYS ALA ARG ALA ARG ALA THR GLY TYR SEQRES 9 N 230 SER SER ILE THR PRO TYR PHE ASP ILE TRP GLY GLN GLY SEQRES 10 N 230 THR LEU VAL THR VAL SER SER ALA SER THR LYS GLY PRO SEQRES 11 N 230 SER VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER SEQRES 12 N 230 GLY GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR SEQRES 13 N 230 PHE PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA SEQRES 14 N 230 LEU THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SEQRES 15 N 230 SER SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL SEQRES 16 N 230 PRO SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN SEQRES 17 N 230 VAL ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS SEQRES 18 N 230 VAL GLU PRO LYS SER CYS ASP GLN SER SEQRES 1 O 214 VAL VAL THR GLN PRO PRO SER VAL SER GLY ALA PRO GLY SEQRES 2 O 214 GLN ARG VAL THR ILE SER CYS THR GLY SER SER SER ASN SEQRES 3 O 214 ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN GLN LEU SEQRES 4 O 214 PRO GLY THR ALA PRO LYS LEU LEU ILE TYR ASP ASN ASN SEQRES 5 O 214 ASN ARG PRO SER GLY VAL PRO ASP ARG PHE SER ALA SER SEQRES 6 O 214 LYS SER GLY THR SER ALA SER LEU ALA ILE THR GLY LEU SEQRES 7 O 214 GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SER TYR SEQRES 8 O 214 ASP ARG SER LEU SER GLY VAL PHE GLY THR GLY THR LYS SEQRES 9 O 214 VAL THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER VAL SEQRES 10 O 214 THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA ASN SEQRES 11 O 214 LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR PRO SEQRES 12 O 214 GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER PRO SEQRES 13 O 214 VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS GLN SEQRES 14 O 214 SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER LEU SEQRES 15 O 214 THR PRO GLU GLN TRP LYS SER HIS LYS SER TYR SER CYS SEQRES 16 O 214 GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR VAL SEQRES 17 O 214 ALA PRO THR GLU CYS SER HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 16 NAG 12(C8 H15 N O6) HELIX 1 AA1 THR A 28 TYR A 32 5 5 HELIX 2 AA2 ARG A 83 THR A 87 5 5 HELIX 3 AA3 GLN B 79 PHE B 83 5 5 HELIX 4 AA4 ASP C 54 LEU C 58 5 5 HELIX 5 AA5 SER C 65 VAL C 84 1 20 HELIX 6 AA6 VAL C 104 ARG C 129 1 26 HELIX 7 AA7 LEU C 130 LEU C 141 1 12 HELIX 8 AA8 ARG C 163 ASN C 172 1 10 HELIX 9 AA9 ASN C 172 ILE C 177 1 6 HELIX 10 AB1 ASN C 178 LYS C 181 5 4 HELIX 11 AB2 ASP C 186 ASN C 197 1 12 HELIX 12 AB3 ASN C 197 ASN C 210 1 14 HELIX 13 AB4 THR C 223 SER C 232 1 10 HELIX 14 AB5 SER C 237 ASN C 247 1 11 HELIX 15 AB6 ASN C 247 GLY C 255 1 9 HELIX 16 AB7 ALA C 338 GLY C 340 5 3 HELIX 17 AB8 ALA C 344 ASN C 351 5 8 HELIX 18 AB9 PRO C 441 PHE C 446 1 6 HELIX 19 AC1 LEU C 460 CYS C 463 1 4 HELIX 20 AC2 THR D 28 TYR D 32 5 5 HELIX 21 AC3 ARG D 83 THR D 87 5 5 HELIX 22 AC4 ASP F 54 LEU F 58 5 5 HELIX 23 AC5 SER F 65 VAL F 84 1 20 HELIX 24 AC6 VAL F 104 ARG F 129 1 26 HELIX 25 AC7 LEU F 130 LEU F 141 1 12 HELIX 26 AC8 ARG F 163 ASN F 172 1 10 HELIX 27 AC9 ASN F 172 ILE F 177 1 6 HELIX 28 AD1 ASP F 186 ASN F 197 1 12 HELIX 29 AD2 ASN F 197 ASN F 210 1 14 HELIX 30 AD3 THR F 223 MET F 234 1 12 HELIX 31 AD4 SER F 237 ASN F 247 1 11 HELIX 32 AD5 ASN F 247 GLY F 255 1 9 HELIX 33 AD6 ALA F 338 GLY F 340 5 3 HELIX 34 AD7 ALA F 344 ILE F 352 5 9 HELIX 35 AD8 PRO F 441 PHE F 446 1 6 HELIX 36 AD9 ASP F 461 CYS F 463 5 3 HELIX 37 AE1 SER G 65 VAL G 84 1 20 HELIX 38 AE2 VAL G 104 ARG G 129 1 26 HELIX 39 AE3 LEU G 130 LEU G 141 1 12 HELIX 40 AE4 ARG G 163 ASN G 172 1 10 HELIX 41 AE5 ASN G 172 ILE G 177 1 6 HELIX 42 AE6 ASN G 178 LYS G 181 5 4 HELIX 43 AE7 LEU G 187 ASN G 197 1 11 HELIX 44 AE8 ASN G 197 ALA G 211 1 15 HELIX 45 AE9 THR G 223 MET G 234 1 12 HELIX 46 AF1 SER G 237 ASN G 247 1 11 HELIX 47 AF2 ASN G 247 GLY G 255 1 9 HELIX 48 AF3 ALA G 338 GLY G 340 5 3 HELIX 49 AF4 ALA G 344 SER G 347 5 4 HELIX 50 AF5 LYS G 348 ASN G 353 1 6 HELIX 51 AF6 PRO G 441 PHE G 446 1 6 HELIX 52 AF7 LEU G 460 CYS G 463 1 4 HELIX 53 AF8 THR H 28 TYR H 32 5 5 HELIX 54 AF9 ARG H 83 THR H 87 5 5 HELIX 55 AG1 THR I 28 TYR I 32 5 5 HELIX 56 AG2 ARG I 87 THR I 91 5 5 HELIX 57 AG3 THR J 28 TYR J 32 5 5 HELIX 58 AG4 ARG J 87 THR J 91 5 5 HELIX 59 AG5 ASN K 28 GLY K 32 5 5 HELIX 60 AG6 GLN K 81 GLU K 85 5 5 HELIX 61 AG7 ASN M 28 GLY M 32 5 5 HELIX 62 AG8 GLN M 81 GLU M 85 5 5 HELIX 63 AG9 THR N 28 TYR N 32 5 5 HELIX 64 AH1 ARG N 87 THR N 91 5 5 HELIX 65 AH2 ASN O 28 GLY O 32 5 5 HELIX 66 AH3 GLN O 81 GLU O 85 5 5 SHEET 1 AA1 4 ARG A 3 GLN A 6 0 SHEET 2 AA1 4 VAL A 18 SER A 25 -1 O LYS A 23 N GLU A 5 SHEET 3 AA1 4 THR A 77 LEU A 82 -1 O LEU A 78 N CYS A 22 SHEET 4 AA1 4 VAL A 67 ASP A 72 -1 N ASP A 72 O THR A 77 SHEET 1 AA2 6 ASP A 10 LYS A 12 0 SHEET 2 AA2 6 THR A 107 VAL A 111 1 O THR A 110 N LYS A 12 SHEET 3 AA2 6 ALA A 88 SER A 98 -1 N TYR A 90 O THR A 107 SHEET 4 AA2 6 ILE A 34 GLN A 39 -1 N HIS A 35 O ALA A 93 SHEET 5 AA2 6 LEU A 45 ILE A 51 -1 O GLU A 46 N ARG A 38 SHEET 6 AA2 6 THR A 57 TYR A 59 -1 O ASN A 58 N TRP A 50 SHEET 1 AA3 4 ASP A 10 LYS A 12 0 SHEET 2 AA3 4 THR A 107 VAL A 111 1 O THR A 110 N LYS A 12 SHEET 3 AA3 4 ALA A 88 SER A 98 -1 N TYR A 90 O THR A 107 SHEET 4 AA3 4 GLY A 100A TRP A 103 -1 O TRP A 100F N ASN A 96 SHEET 1 AA4 4 THR B 5 SER B 7 0 SHEET 2 AA4 4 VAL B 19 ARG B 24 -1 O ARG B 24 N THR B 5 SHEET 3 AA4 4 GLY B 70 ILE B 75 -1 O LEU B 73 N ILE B 21 SHEET 4 AA4 4 PHE B 62 SER B 65 -1 N SER B 65 O THR B 72 SHEET 1 AA5 5 THR B 10 ALA B 13 0 SHEET 2 AA5 5 THR B 102 ILE B 106 1 O GLU B 105 N ALA B 13 SHEET 3 AA5 5 THR B 85 GLN B 90 -1 N TYR B 86 O THR B 102 SHEET 4 AA5 5 LEU B 33 GLN B 38 -1 N GLN B 38 O THR B 85 SHEET 5 AA5 5 LYS B 45 ILE B 48 -1 O ILE B 48 N TRP B 35 SHEET 1 AA6 4 THR B 10 ALA B 13 0 SHEET 2 AA6 4 THR B 102 ILE B 106 1 O GLU B 105 N ALA B 13 SHEET 3 AA6 4 THR B 85 GLN B 90 -1 N TYR B 86 O THR B 102 SHEET 4 AA6 4 THR B 97 PHE B 98 -1 O THR B 97 N GLN B 90 SHEET 1 AA7 7 GLU C 327 ARG C 329 0 SHEET 2 AA7 7 HIS C 332 ASP C 336 -1 O PHE C 334 N GLU C 327 SHEET 3 AA7 7 SER C 29 ARG C 40 1 N ARG C 40 O CYS C 335 SHEET 4 AA7 7 VAL C 278 ALA C 288 -1 O LYS C 287 N THR C 30 SHEET 5 AA7 7 GLY C 308 ASN C 313 -1 O GLY C 308 N VAL C 286 SHEET 6 AA7 7 SER C 316 TYR C 320 -1 O SER C 316 N ASN C 313 SHEET 7 AA7 7 ILE C 341 VAL C 343 -1 O ILE C 341 N TYR C 319 SHEET 1 AA8 5 GLU C 327 ARG C 329 0 SHEET 2 AA8 5 HIS C 332 ASP C 336 -1 O PHE C 334 N GLU C 327 SHEET 3 AA8 5 SER C 29 ARG C 40 1 N ARG C 40 O CYS C 335 SHEET 4 AA8 5 LYS C 20 LEU C 24 -1 N LYS C 20 O GLU C 33 SHEET 5 AA8 5 GLU C 433 ILE C 437 1 O HIS C 435 N TYR C 23 SHEET 1 AA9 6 GLU C 146 THR C 150 0 SHEET 2 AA9 6 ARG C 156 VAL C 162 -1 O ALA C 159 N CYS C 147 SHEET 3 AA9 6 GLY C 42 GLU C 51 1 N THR C 49 O VAL C 162 SHEET 4 AA9 6 SER C 266 ILE C 275 -1 O LEU C 273 N TYR C 44 SHEET 5 AA9 6 PHE C 256 VAL C 262 -1 N PHE C 256 O GLN C 272 SHEET 6 AA9 6 ILE C 213 THR C 214 -1 N THR C 214 O GLY C 257 SHEET 1 AB1 4 SER C 291 GLU C 294 0 SHEET 2 AB1 4 TYR C 299 ARG C 304 -1 O ALA C 300 N SER C 293 SHEET 3 AB1 4 LYS C 362 GLY C 366 -1 O SER C 364 N LEU C 303 SHEET 4 AB1 4 GLN C 455 ALA C 459 -1 O VAL C 458 N VAL C 363 SHEET 1 AB2 3 MET C 372 SER C 376 0 SHEET 2 AB2 3 GLY C 379 CYS C 384 -1 O LEU C 381 N ALA C 374 SHEET 3 AB2 3 GLY C 406 THR C 411 -1 O SER C 408 N VAL C 382 SHEET 1 AB3 4 GLY C 398 GLN C 402 0 SHEET 2 AB3 4 CYS C 390 SER C 394 -1 N SER C 394 O GLY C 398 SHEET 3 AB3 4 THR C 417 ILE C 420 -1 O THR C 419 N SER C 391 SHEET 4 AB3 4 THR C 423 GLN C 426 -1 O TYR C 425 N VAL C 418 SHEET 1 AB4 2 ASP C 447 PRO C 448 0 SHEET 2 AB4 2 PHE C 464 GLU C 465 -1 O GLU C 465 N ASP C 447 SHEET 1 AB5 4 ARG D 3 GLN D 6 0 SHEET 2 AB5 4 VAL D 18 SER D 25 -1 O LYS D 23 N GLU D 5 SHEET 3 AB5 4 THR D 77 LEU D 82 -1 O LEU D 78 N CYS D 22 SHEET 4 AB5 4 VAL D 67 ASP D 72 -1 N ASP D 72 O THR D 77 SHEET 1 AB6 6 ASP D 10 LYS D 12 0 SHEET 2 AB6 6 THR D 107 VAL D 111 1 O THR D 110 N LYS D 12 SHEET 3 AB6 6 ALA D 88 SER D 98 -1 N TYR D 90 O THR D 107 SHEET 4 AB6 6 ILE D 34 GLN D 39 -1 N HIS D 35 O ALA D 93 SHEET 5 AB6 6 LEU D 45 ILE D 51 -1 O GLU D 46 N ARG D 38 SHEET 6 AB6 6 THR D 57 TYR D 59 -1 O ASN D 58 N TRP D 50 SHEET 1 AB7 4 ASP D 10 LYS D 12 0 SHEET 2 AB7 4 THR D 107 VAL D 111 1 O THR D 110 N LYS D 12 SHEET 3 AB7 4 ALA D 88 SER D 98 -1 N TYR D 90 O THR D 107 SHEET 4 AB7 4 GLY D 100A TRP D 103 -1 O TRP D 100F N ASN D 96 SHEET 1 AB8 4 MET E 4 SER E 7 0 SHEET 2 AB8 4 VAL E 19 ALA E 25 -1 O ARG E 24 N THR E 5 SHEET 3 AB8 4 GLY E 70 ILE E 75 -1 O LEU E 73 N ILE E 21 SHEET 4 AB8 4 PHE E 62 SER E 65 -1 N SER E 65 O THR E 72 SHEET 1 AB9 5 THR E 10 ALA E 13 0 SHEET 2 AB9 5 THR E 102 ILE E 106 1 O GLU E 105 N ALA E 13 SHEET 3 AB9 5 THR E 85 GLN E 90 -1 N TYR E 86 O THR E 102 SHEET 4 AB9 5 LEU E 33 GLN E 38 -1 N GLN E 38 O THR E 85 SHEET 5 AB9 5 LYS E 45 ILE E 48 -1 O LEU E 47 N TRP E 35 SHEET 1 AC1 4 THR E 10 ALA E 13 0 SHEET 2 AC1 4 THR E 102 ILE E 106 1 O GLU E 105 N ALA E 13 SHEET 3 AC1 4 THR E 85 GLN E 90 -1 N TYR E 86 O THR E 102 SHEET 4 AC1 4 THR E 97 PHE E 98 -1 O THR E 97 N GLN E 90 SHEET 1 AC2 7 GLU F 327 ARG F 329 0 SHEET 2 AC2 7 HIS F 332 ASP F 336 -1 O PHE F 334 N GLU F 327 SHEET 3 AC2 7 SER F 29 ARG F 40 1 N ARG F 40 O CYS F 335 SHEET 4 AC2 7 VAL F 278 ALA F 288 -1 O LYS F 287 N THR F 30 SHEET 5 AC2 7 GLY F 308 ASN F 313 -1 O GLY F 308 N VAL F 286 SHEET 6 AC2 7 SER F 316 TYR F 320 -1 O VAL F 318 N CYS F 311 SHEET 7 AC2 7 ILE F 341 VAL F 343 -1 O ILE F 341 N TYR F 319 SHEET 1 AC3 5 GLU F 327 ARG F 329 0 SHEET 2 AC3 5 HIS F 332 ASP F 336 -1 O PHE F 334 N GLU F 327 SHEET 3 AC3 5 SER F 29 ARG F 40 1 N ARG F 40 O CYS F 335 SHEET 4 AC3 5 LYS F 20 LEU F 24 -1 N LYS F 20 O GLU F 33 SHEET 5 AC3 5 GLU F 433 ILE F 437 1 O HIS F 435 N GLU F 21 SHEET 1 AC4 6 GLU F 146 THR F 150 0 SHEET 2 AC4 6 ARG F 156 VAL F 162 -1 O ALA F 159 N CYS F 147 SHEET 3 AC4 6 GLY F 42 GLU F 51 1 N VAL F 47 O LEU F 158 SHEET 4 AC4 6 SER F 266 ILE F 275 -1 O LEU F 273 N TYR F 44 SHEET 5 AC4 6 PHE F 256 TYR F 263 -1 N TYR F 263 O SER F 266 SHEET 6 AC4 6 ILE F 213 THR F 214 -1 N THR F 214 O GLY F 257 SHEET 1 AC5 4 SER F 291 LYS F 295 0 SHEET 2 AC5 4 ASN F 298 ARG F 304 -1 O ALA F 300 N SER F 293 SHEET 3 AC5 4 LYS F 362 GLY F 366 -1 O SER F 364 N LEU F 303 SHEET 4 AC5 4 GLN F 455 ALA F 459 -1 O VAL F 458 N VAL F 363 SHEET 1 AC6 3 MET F 372 SER F 376 0 SHEET 2 AC6 3 GLY F 379 CYS F 384 -1 O LEU F 381 N ALA F 374 SHEET 3 AC6 3 GLY F 406 THR F 411 -1 O SER F 408 N VAL F 382 SHEET 1 AC7 4 GLY F 398 GLN F 402 0 SHEET 2 AC7 4 CYS F 390 SER F 394 -1 N SER F 394 O GLY F 398 SHEET 3 AC7 4 THR F 417 ILE F 420 -1 O THR F 419 N SER F 391 SHEET 4 AC7 4 THR F 423 GLN F 426 -1 O TYR F 425 N VAL F 418 SHEET 1 AC8 7 GLU G 327 ARG G 329 0 SHEET 2 AC8 7 HIS G 332 ASP G 336 -1 O PHE G 334 N GLU G 327 SHEET 3 AC8 7 SER G 29 ARG G 40 1 N ARG G 40 O CYS G 335 SHEET 4 AC8 7 VAL G 278 ALA G 288 -1 O LYS G 287 N THR G 30 SHEET 5 AC8 7 GLY G 308 ASN G 313 -1 O GLY G 308 N VAL G 286 SHEET 6 AC8 7 SER G 316 TYR G 320 -1 O SER G 316 N ASN G 313 SHEET 7 AC8 7 ILE G 341 VAL G 343 -1 O ILE G 341 N TYR G 319 SHEET 1 AC9 5 GLU G 327 ARG G 329 0 SHEET 2 AC9 5 HIS G 332 ASP G 336 -1 O PHE G 334 N GLU G 327 SHEET 3 AC9 5 SER G 29 ARG G 40 1 N ARG G 40 O CYS G 335 SHEET 4 AC9 5 LYS G 20 LEU G 24 -1 N LYS G 20 O GLU G 33 SHEET 5 AC9 5 GLU G 433 ILE G 437 1 O HIS G 435 N TYR G 23 SHEET 1 AD1 6 GLU G 146 THR G 150 0 SHEET 2 AD1 6 ARG G 156 VAL G 162 -1 O ALA G 159 N CYS G 147 SHEET 3 AD1 6 GLY G 42 GLU G 51 1 N THR G 49 O VAL G 162 SHEET 4 AD1 6 SER G 266 ILE G 275 -1 O LEU G 273 N TYR G 44 SHEET 5 AD1 6 PHE G 256 VAL G 262 -1 N PHE G 256 O GLN G 272 SHEET 6 AD1 6 ILE G 213 THR G 214 -1 N THR G 214 O GLY G 257 SHEET 1 AD2 4 SER G 291 GLU G 294 0 SHEET 2 AD2 4 TYR G 299 ARG G 304 -1 O ALA G 300 N SER G 293 SHEET 3 AD2 4 LYS G 362 GLY G 366 -1 O SER G 364 N LEU G 303 SHEET 4 AD2 4 GLN G 455 ALA G 459 -1 O VAL G 458 N VAL G 363 SHEET 1 AD3 3 MET G 372 SER G 376 0 SHEET 2 AD3 3 GLY G 379 CYS G 384 -1 O GLY G 379 N SER G 376 SHEET 3 AD3 3 GLY G 406 THR G 411 -1 O ILE G 410 N ALA G 380 SHEET 1 AD4 4 GLY G 398 GLN G 402 0 SHEET 2 AD4 4 CYS G 390 SER G 394 -1 N SER G 394 O GLY G 398 SHEET 3 AD4 4 THR G 417 ILE G 420 -1 O THR G 419 N SER G 391 SHEET 4 AD4 4 THR G 423 GLN G 426 -1 O TYR G 425 N VAL G 418 SHEET 1 AD5 2 ASP G 447 PRO G 448 0 SHEET 2 AD5 2 PHE G 464 GLU G 465 -1 O GLU G 465 N ASP G 447 SHEET 1 AD6 4 ARG H 3 GLN H 6 0 SHEET 2 AD6 4 VAL H 18 SER H 25 -1 O LYS H 23 N GLU H 5 SHEET 3 AD6 4 THR H 77 LEU H 82 -1 O LEU H 80 N VAL H 20 SHEET 4 AD6 4 VAL H 67 ASP H 72 -1 N ASP H 72 O THR H 77 SHEET 1 AD7 6 ASP H 10 LYS H 12 0 SHEET 2 AD7 6 THR H 107 VAL H 111 1 O THR H 110 N LYS H 12 SHEET 3 AD7 6 ALA H 88 SER H 98 -1 N TYR H 90 O THR H 107 SHEET 4 AD7 6 TYR H 33 GLN H 39 -1 N HIS H 35 O ALA H 93 SHEET 5 AD7 6 LEU H 45 ILE H 51 -1 O GLU H 46 N ARG H 38 SHEET 6 AD7 6 THR H 57 TYR H 59 -1 O ASN H 58 N TRP H 50 SHEET 1 AD8 4 ASP H 10 LYS H 12 0 SHEET 2 AD8 4 THR H 107 VAL H 111 1 O THR H 110 N LYS H 12 SHEET 3 AD8 4 ALA H 88 SER H 98 -1 N TYR H 90 O THR H 107 SHEET 4 AD8 4 GLY H 100A TRP H 103 -1 O TRP H 100F N ASN H 96 SHEET 1 AD9 4 GLN I 3 SER I 7 0 SHEET 2 AD9 4 LEU I 18 SER I 25 -1 O SER I 21 N SER I 7 SHEET 3 AD9 4 SER I 78 MET I 83 -1 O LEU I 79 N CYS I 22 SHEET 4 AD9 4 PHE I 68 ASP I 73 -1 N SER I 71 O PHE I 80 SHEET 1 AE1 6 LEU I 11 VAL I 12 0 SHEET 2 AE1 6 THR I 118 VAL I 122 1 O THR I 121 N VAL I 12 SHEET 3 AE1 6 ALA I 92 ARG I 100 -1 N TYR I 94 O THR I 118 SHEET 4 AE1 6 SER I 33 GLN I 39 -1 N VAL I 37 O PHE I 95 SHEET 5 AE1 6 LEU I 45 ILE I 51 -1 O GLU I 46 N ARG I 38 SHEET 6 AE1 6 SER I 58 TYR I 60 -1 O ASP I 59 N SER I 50 SHEET 1 AE2 4 LEU I 11 VAL I 12 0 SHEET 2 AE2 4 THR I 118 VAL I 122 1 O THR I 121 N VAL I 12 SHEET 3 AE2 4 ALA I 92 ARG I 100 -1 N TYR I 94 O THR I 118 SHEET 4 AE2 4 TYR I 110 TRP I 114 -1 O TYR I 110 N ARG I 100 SHEET 1 AE3 4 GLN J 3 SER J 7 0 SHEET 2 AE3 4 LEU J 18 SER J 25 -1 O SER J 21 N SER J 7 SHEET 3 AE3 4 SER J 78 MET J 83 -1 O LEU J 79 N CYS J 22 SHEET 4 AE3 4 PHE J 68 ASP J 73 -1 N SER J 71 O PHE J 80 SHEET 1 AE4 6 LEU J 11 VAL J 12 0 SHEET 2 AE4 6 THR J 118 VAL J 122 1 O THR J 121 N VAL J 12 SHEET 3 AE4 6 ALA J 92 ARG J 100 -1 N TYR J 94 O THR J 118 SHEET 4 AE4 6 SER J 33 GLN J 39 -1 N VAL J 37 O PHE J 95 SHEET 5 AE4 6 LEU J 45 ILE J 51 -1 O GLU J 46 N ARG J 38 SHEET 6 AE4 6 SER J 58 TYR J 60 -1 O ASP J 59 N SER J 50 SHEET 1 AE5 4 LEU J 11 VAL J 12 0 SHEET 2 AE5 4 THR J 118 VAL J 122 1 O THR J 121 N VAL J 12 SHEET 3 AE5 4 ALA J 92 ARG J 100 -1 N TYR J 94 O THR J 118 SHEET 4 AE5 4 TYR J 110 TRP J 114 -1 O TYR J 110 N ARG J 100 SHEET 1 AE6 5 SER K 9 SER K 11 0 SHEET 2 AE6 5 THR K 105 THR K 108 1 O THR K 108 N VAL K 10 SHEET 3 AE6 5 ASP K 87 ASP K 94 -1 N TYR K 88 O THR K 105 SHEET 4 AE6 5 HIS K 36 GLN K 40 -1 N HIS K 36 O GLN K 91 SHEET 5 AE6 5 LYS K 47 ILE K 50 -1 O LYS K 47 N GLN K 39 SHEET 1 AE7 4 SER K 9 SER K 11 0 SHEET 2 AE7 4 THR K 105 THR K 108 1 O THR K 108 N VAL K 10 SHEET 3 AE7 4 ASP K 87 ASP K 94 -1 N TYR K 88 O THR K 105 SHEET 4 AE7 4 SER K 98 PHE K 101 -1 O SER K 98 N ASP K 94 SHEET 1 AE8 3 VAL K 18 THR K 23 0 SHEET 2 AE8 3 SER K 72 ILE K 77 -1 O LEU K 75 N ILE K 20 SHEET 3 AE8 3 PHE K 64 SER K 69 -1 N SER K 69 O SER K 72 SHEET 1 AE9 4 MET L 4 SER L 7 0 SHEET 2 AE9 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AE9 4 GLY L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AE9 4 PHE L 62 SER L 67 -1 N SER L 63 O THR L 74 SHEET 1 AF1 5 THR L 10 ALA L 13 0 SHEET 2 AF1 5 THR L 102 ILE L 106 1 O GLU L 105 N ALA L 13 SHEET 3 AF1 5 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AF1 5 LEU L 33 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AF1 5 LYS L 45 ILE L 48 -1 O LYS L 45 N GLN L 37 SHEET 1 AF2 5 SER M 9 SER M 11 0 SHEET 2 AF2 5 THR M 105 THR M 108 1 O THR M 108 N VAL M 10 SHEET 3 AF2 5 ASP M 87 ASP M 94 -1 N TYR M 88 O THR M 105 SHEET 4 AF2 5 HIS M 36 GLN M 40 -1 N HIS M 36 O GLN M 91 SHEET 5 AF2 5 LYS M 47 ILE M 50 -1 O LYS M 47 N GLN M 39 SHEET 1 AF3 4 SER M 9 SER M 11 0 SHEET 2 AF3 4 THR M 105 THR M 108 1 O THR M 108 N VAL M 10 SHEET 3 AF3 4 ASP M 87 ASP M 94 -1 N TYR M 88 O THR M 105 SHEET 4 AF3 4 SER M 98 PHE M 101 -1 O SER M 98 N ASP M 94 SHEET 1 AF4 3 VAL M 18 THR M 23 0 SHEET 2 AF4 3 SER M 72 ILE M 77 -1 O LEU M 75 N ILE M 20 SHEET 3 AF4 3 PHE M 64 SER M 69 -1 N SER M 69 O SER M 72 SHEET 1 AF5 4 GLN N 3 VAL N 5 0 SHEET 2 AF5 4 LEU N 18 SER N 25 -1 O ALA N 23 N VAL N 5 SHEET 3 AF5 4 SER N 78 MET N 83 -1 O LEU N 79 N CYS N 22 SHEET 4 AF5 4 THR N 69 ASP N 73 -1 N SER N 71 O PHE N 80 SHEET 1 AF6 6 LEU N 11 VAL N 12 0 SHEET 2 AF6 6 THR N 118 VAL N 122 1 O THR N 121 N VAL N 12 SHEET 3 AF6 6 ALA N 92 ARG N 100 -1 N TYR N 94 O THR N 118 SHEET 4 AF6 6 SER N 33 GLN N 39 -1 N VAL N 37 O PHE N 95 SHEET 5 AF6 6 LEU N 45 ILE N 51 -1 O GLU N 46 N ARG N 38 SHEET 6 AF6 6 SER N 58 TYR N 60 -1 O ASP N 59 N SER N 50 SHEET 1 AF7 4 LEU N 11 VAL N 12 0 SHEET 2 AF7 4 THR N 118 VAL N 122 1 O THR N 121 N VAL N 12 SHEET 3 AF7 4 ALA N 92 ARG N 100 -1 N TYR N 94 O THR N 118 SHEET 4 AF7 4 TYR N 110 TRP N 114 -1 O TYR N 110 N ARG N 100 SHEET 1 AF8 5 SER O 9 SER O 11 0 SHEET 2 AF8 5 THR O 105 THR O 108 1 O THR O 108 N VAL O 10 SHEET 3 AF8 5 ASP O 87 ASP O 94 -1 N TYR O 88 O THR O 105 SHEET 4 AF8 5 HIS O 36 GLN O 40 -1 N HIS O 36 O GLN O 91 SHEET 5 AF8 5 LYS O 47 ILE O 50 -1 O LYS O 47 N GLN O 39 SHEET 1 AF9 4 SER O 9 SER O 11 0 SHEET 2 AF9 4 THR O 105 THR O 108 1 O THR O 108 N VAL O 10 SHEET 3 AF9 4 ASP O 87 ASP O 94 -1 N TYR O 88 O THR O 105 SHEET 4 AF9 4 SER O 98 PHE O 101 -1 O SER O 98 N ASP O 94 SHEET 1 AG1 3 VAL O 18 THR O 23 0 SHEET 2 AG1 3 SER O 72 ILE O 77 -1 O LEU O 75 N ILE O 20 SHEET 3 AG1 3 PHE O 64 SER O 69 -1 N SER O 69 O SER O 72 SSBOND 1 CYS A 22 CYS A 92 1555 1555 2.04 SSBOND 2 CYS A 97 CYS A 100B 1555 1555 2.03 SSBOND 3 CYS B 23 CYS B 88 1555 1555 2.04 SSBOND 4 CYS C 28 CYS C 407 1555 1555 2.03 SSBOND 5 CYS C 60 CYS C 182 1555 1555 2.03 SSBOND 6 CYS C 110 CYS C 322 1555 1555 2.03 SSBOND 7 CYS C 127 CYS C 153 1555 1555 2.04 SSBOND 8 CYS C 140 CYS C 147 1555 1555 2.03 SSBOND 9 CYS C 283 CYS C 311 1555 1555 2.03 SSBOND 10 CYS C 292 CYS C 301 1555 1555 2.03 SSBOND 11 CYS C 326 CYS C 335 1555 1555 2.03 SSBOND 12 CYS C 350 CYS C 361 1555 1555 2.03 SSBOND 13 CYS C 365 CYS C 463 1555 1555 2.02 SSBOND 14 CYS C 384 CYS C 390 1555 1555 2.03 SSBOND 15 CYS D 22 CYS D 92 1555 1555 2.04 SSBOND 16 CYS D 97 CYS D 100B 1555 1555 2.03 SSBOND 17 CYS E 23 CYS E 88 1555 1555 2.04 SSBOND 18 CYS F 28 CYS F 407 1555 1555 2.03 SSBOND 19 CYS F 60 CYS F 182 1555 1555 2.03 SSBOND 20 CYS F 110 CYS F 322 1555 1555 2.03 SSBOND 21 CYS F 127 CYS F 153 1555 1555 2.03 SSBOND 22 CYS F 140 CYS F 147 1555 1555 2.03 SSBOND 23 CYS F 283 CYS F 311 1555 1555 2.03 SSBOND 24 CYS F 292 CYS F 301 1555 1555 2.03 SSBOND 25 CYS F 326 CYS F 335 1555 1555 2.04 SSBOND 26 CYS F 350 CYS F 361 1555 1555 2.03 SSBOND 27 CYS F 365 CYS F 463 1555 1555 2.02 SSBOND 28 CYS F 384 CYS F 390 1555 1555 2.03 SSBOND 29 CYS G 28 CYS G 407 1555 1555 2.03 SSBOND 30 CYS G 60 CYS G 182 1555 1555 2.03 SSBOND 31 CYS G 110 CYS G 322 1555 1555 2.03 SSBOND 32 CYS G 127 CYS G 153 1555 1555 2.04 SSBOND 33 CYS G 140 CYS G 147 1555 1555 2.03 SSBOND 34 CYS G 283 CYS G 311 1555 1555 2.03 SSBOND 35 CYS G 292 CYS G 301 1555 1555 2.03 SSBOND 36 CYS G 326 CYS G 335 1555 1555 2.03 SSBOND 37 CYS G 350 CYS G 361 1555 1555 2.03 SSBOND 38 CYS G 365 CYS G 463 1555 1555 2.02 SSBOND 39 CYS G 384 CYS G 390 1555 1555 2.03 SSBOND 40 CYS H 22 CYS H 92 1555 1555 2.04 SSBOND 41 CYS H 97 CYS H 100B 1555 1555 2.03 SSBOND 42 CYS I 22 CYS I 96 1555 1555 2.04 SSBOND 43 CYS J 22 CYS J 96 1555 1555 2.04 SSBOND 44 CYS K 22 CYS K 90 1555 1555 2.04 SSBOND 45 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 46 CYS M 22 CYS M 90 1555 1555 2.04 SSBOND 47 CYS N 22 CYS N 96 1555 1555 2.04 SSBOND 48 CYS O 22 CYS O 90 1555 1555 2.04 LINK ND2 ASN A 96 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN C 172 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN D 96 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN F 172 C1 NAG S 1 1555 1555 1.45 LINK ND2 ASN G 172 C1 NAG T 1 1555 1555 1.45 LINK ND2 ASN H 96 C1 NAG U 1 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.43 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.46 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.43 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.43 CISPEP 1 SER B 7 PRO B 8 0 -13.30 CISPEP 2 TYR B 94 PRO B 95 0 7.13 CISPEP 3 PHE C 451 PRO C 452 0 -16.16 CISPEP 4 SER E 7 PRO E 8 0 -12.21 CISPEP 5 TYR E 94 PRO E 95 0 4.33 CISPEP 6 PHE F 451 PRO F 452 0 -13.62 CISPEP 7 PHE G 451 PRO G 452 0 -16.75 CISPEP 8 SER L 7 PRO L 8 0 -13.28 CISPEP 9 TYR L 94 PRO L 95 0 6.75 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000