HEADER VIRAL PROTEIN 18-FEB-22 7U0P TITLE SARS-COV2 S PROTEIN STRUCTURE IN COMPLEX WITH NEUTRALIZING MONOCLONAL TITLE 2 ANTIBODY 002-S21F2 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: MAB 002-S21F2 HEAVY CHAIN; COMPND 8 CHAIN: E, D; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: MAB 002_S21F2 LIGHT CHAIN; COMPND 12 CHAIN: I, F; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: FREESTYLE 293-F; SOURCE 10 MOL_ID: 2; SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 12 ORGANISM_COMMON: HUMAN; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 17 EXPRESSION_SYSTEM_CELL_LINE: EXPI293; SOURCE 18 MOL_ID: 3; SOURCE 19 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 20 ORGANISM_COMMON: HUMAN; SOURCE 21 ORGANISM_TAXID: 9606; SOURCE 22 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 23 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 24 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 25 EXPRESSION_SYSTEM_CELL_LINE: EXPI293 KEYWDS SARS-COV2 6P SPIKE PROTEIN, IMMUNE COMPLEX, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR A.PATEL,E.ORTLUND JRNL AUTH A.PATEL,E.ORTLUND JRNL TITL SARS-COV2 S PROTEIN STRUCTURE IN COMPLEX WITH NEUTRALIZING JRNL TITL 2 MONOCLONAL ANTIBODY 002-S21F2 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.76 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, UCSF CHIMERAX, CRYOSPARC, REMARK 3 CRYOSPARC, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : CORRELATION COEFFICIENT REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.760 REMARK 3 NUMBER OF PARTICLES : 129931 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 7U0P COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB. REMARK 100 THE DEPOSITION ID IS D_1000263252. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV2 SPIKE TRIMER IN REMARK 245 COMPLEX WITH MONOCLONAL REMARK 245 ANTIBODY; SPIKE GLYCOPROTEIN; REMARK 245 MAB 002-S21F2 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.70 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : WAIT TIME 20 SECONDS AND BLOT REMARK 245 TIME 3 SECONDS REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 3863 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 51.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 79000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEPTAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, E, D, I, F, B1, G, REMARK 350 AND CHAINS: H, J, K REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 VAL A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 PRO A 9 REMARK 465 LEU A 10 REMARK 465 VAL A 11 REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 618 REMARK 465 GLU A 619 REMARK 465 VAL A 620 REMARK 465 PRO A 621 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 PRO A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 THR A 941 REMARK 465 PRO A 942 REMARK 465 SER A 943 REMARK 465 SER A 1147 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 VAL B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 PRO B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 676 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 ASN B 679 REMARK 465 SER B 680 REMARK 465 PRO B 681 REMARK 465 GLY B 682 REMARK 465 SER B 683 REMARK 465 ALA B 684 REMARK 465 SER B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 SER B 689 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 MET C 1 REMARK 465 PHE C 2 REMARK 465 VAL C 3 REMARK 465 PHE C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 PRO C 9 REMARK 465 LEU C 10 REMARK 465 VAL C 11 REMARK 465 SER C 12 REMARK 465 SER C 13 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 618 REMARK 465 GLU C 619 REMARK 465 VAL C 620 REMARK 465 PRO C 621 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 PRO C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 THR C 941 REMARK 465 PRO C 942 REMARK 465 SER C 943 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 THR E 225 REMARK 465 HIS E 226 REMARK 465 THR E 227 REMARK 465 CYS E 228 REMARK 465 PRO E 229 REMARK 465 PRO E 230 REMARK 465 CYS E 231 REMARK 465 PRO E 232 REMARK 465 ALA E 233 REMARK 465 PRO E 234 REMARK 465 GLU E 235 REMARK 465 LEU E 236 REMARK 465 LEU E 237 REMARK 465 GLY E 238 REMARK 465 GLY E 239 REMARK 465 PRO E 240 REMARK 465 SER E 241 REMARK 465 VAL E 242 REMARK 465 PHE E 243 REMARK 465 LEU E 244 REMARK 465 PHE E 245 REMARK 465 PRO E 246 REMARK 465 PRO E 247 REMARK 465 LYS E 248 REMARK 465 PRO E 249 REMARK 465 LYS E 250 REMARK 465 ASP E 251 REMARK 465 THR E 252 REMARK 465 LEU E 253 REMARK 465 MET E 254 REMARK 465 ILE E 255 REMARK 465 SER E 256 REMARK 465 ARG E 257 REMARK 465 THR E 258 REMARK 465 PRO E 259 REMARK 465 GLU E 260 REMARK 465 VAL E 261 REMARK 465 THR E 262 REMARK 465 CYS E 263 REMARK 465 VAL E 264 REMARK 465 VAL E 265 REMARK 465 VAL E 266 REMARK 465 ASP E 267 REMARK 465 VAL E 268 REMARK 465 SER E 269 REMARK 465 HIS E 270 REMARK 465 GLU E 271 REMARK 465 ASP E 272 REMARK 465 PRO E 273 REMARK 465 GLU E 274 REMARK 465 VAL E 275 REMARK 465 LYS E 276 REMARK 465 PHE E 277 REMARK 465 ASN E 278 REMARK 465 TRP E 279 REMARK 465 TYR E 280 REMARK 465 VAL E 281 REMARK 465 ASP E 282 REMARK 465 GLY E 283 REMARK 465 VAL E 284 REMARK 465 GLU E 285 REMARK 465 VAL E 286 REMARK 465 HIS E 287 REMARK 465 ASN E 288 REMARK 465 ALA E 289 REMARK 465 LYS E 290 REMARK 465 THR E 291 REMARK 465 LYS E 292 REMARK 465 PRO E 293 REMARK 465 ARG E 294 REMARK 465 GLU E 295 REMARK 465 GLU E 296 REMARK 465 GLN E 297 REMARK 465 TYR E 298 REMARK 465 ASN E 299 REMARK 465 SER E 300 REMARK 465 THR E 301 REMARK 465 TYR E 302 REMARK 465 ARG E 303 REMARK 465 VAL E 304 REMARK 465 VAL E 305 REMARK 465 SER E 306 REMARK 465 VAL E 307 REMARK 465 LEU E 308 REMARK 465 THR E 309 REMARK 465 VAL E 310 REMARK 465 LEU E 311 REMARK 465 HIS E 312 REMARK 465 GLN E 313 REMARK 465 ASP E 314 REMARK 465 TRP E 315 REMARK 465 LEU E 316 REMARK 465 ASN E 317 REMARK 465 GLY E 318 REMARK 465 LYS E 319 REMARK 465 GLU E 320 REMARK 465 TYR E 321 REMARK 465 LYS E 322 REMARK 465 CYS E 323 REMARK 465 LYS E 324 REMARK 465 VAL E 325 REMARK 465 SER E 326 REMARK 465 ASN E 327 REMARK 465 LYS E 328 REMARK 465 ALA E 329 REMARK 465 LEU E 330 REMARK 465 PRO E 331 REMARK 465 ALA E 332 REMARK 465 PRO E 333 REMARK 465 ILE E 334 REMARK 465 GLU E 335 REMARK 465 LYS E 336 REMARK 465 THR E 337 REMARK 465 ILE E 338 REMARK 465 SER E 339 REMARK 465 LYS E 340 REMARK 465 ALA E 341 REMARK 465 LYS E 342 REMARK 465 GLY E 343 REMARK 465 GLN E 344 REMARK 465 PRO E 345 REMARK 465 ARG E 346 REMARK 465 GLU E 347 REMARK 465 PRO E 348 REMARK 465 GLN E 349 REMARK 465 VAL E 350 REMARK 465 TYR E 351 REMARK 465 THR E 352 REMARK 465 LEU E 353 REMARK 465 PRO E 354 REMARK 465 PRO E 355 REMARK 465 SER E 356 REMARK 465 ARG E 357 REMARK 465 GLU E 358 REMARK 465 GLU E 359 REMARK 465 MET E 360 REMARK 465 THR E 361 REMARK 465 LYS E 362 REMARK 465 ASN E 363 REMARK 465 GLN E 364 REMARK 465 VAL E 365 REMARK 465 SER E 366 REMARK 465 LEU E 367 REMARK 465 THR E 368 REMARK 465 CYS E 369 REMARK 465 LEU E 370 REMARK 465 VAL E 371 REMARK 465 LYS E 372 REMARK 465 GLY E 373 REMARK 465 PHE E 374 REMARK 465 TYR E 375 REMARK 465 PRO E 376 REMARK 465 SER E 377 REMARK 465 ASP E 378 REMARK 465 ILE E 379 REMARK 465 ALA E 380 REMARK 465 VAL E 381 REMARK 465 GLU E 382 REMARK 465 TRP E 383 REMARK 465 GLU E 384 REMARK 465 SER E 385 REMARK 465 ASN E 386 REMARK 465 GLY E 387 REMARK 465 GLN E 388 REMARK 465 PRO E 389 REMARK 465 GLU E 390 REMARK 465 ASN E 391 REMARK 465 ASN E 392 REMARK 465 TYR E 393 REMARK 465 LYS E 394 REMARK 465 THR E 395 REMARK 465 THR E 396 REMARK 465 PRO E 397 REMARK 465 PRO E 398 REMARK 465 VAL E 399 REMARK 465 LEU E 400 REMARK 465 ASP E 401 REMARK 465 SER E 402 REMARK 465 ASP E 403 REMARK 465 GLY E 404 REMARK 465 SER E 405 REMARK 465 PHE E 406 REMARK 465 PHE E 407 REMARK 465 LEU E 408 REMARK 465 TYR E 409 REMARK 465 SER E 410 REMARK 465 LYS E 411 REMARK 465 LEU E 412 REMARK 465 THR E 413 REMARK 465 VAL E 414 REMARK 465 ASP E 415 REMARK 465 LYS E 416 REMARK 465 SER E 417 REMARK 465 ARG E 418 REMARK 465 TRP E 419 REMARK 465 GLN E 420 REMARK 465 GLN E 421 REMARK 465 GLY E 422 REMARK 465 ASN E 423 REMARK 465 VAL E 424 REMARK 465 PHE E 425 REMARK 465 SER E 426 REMARK 465 CYS E 427 REMARK 465 SER E 428 REMARK 465 VAL E 429 REMARK 465 MET E 430 REMARK 465 HIS E 431 REMARK 465 GLU E 432 REMARK 465 ALA E 433 REMARK 465 LEU E 434 REMARK 465 HIS E 435 REMARK 465 ASN E 436 REMARK 465 HIS E 437 REMARK 465 TYR E 438 REMARK 465 THR E 439 REMARK 465 GLN E 440 REMARK 465 LYS E 441 REMARK 465 SER E 442 REMARK 465 LEU E 443 REMARK 465 SER E 444 REMARK 465 LEU E 445 REMARK 465 SER E 446 REMARK 465 PRO E 447 REMARK 465 GLY E 448 REMARK 465 LYS E 449 REMARK 465 THR D 225 REMARK 465 HIS D 226 REMARK 465 THR D 227 REMARK 465 CYS D 228 REMARK 465 PRO D 229 REMARK 465 PRO D 230 REMARK 465 CYS D 231 REMARK 465 PRO D 232 REMARK 465 ALA D 233 REMARK 465 PRO D 234 REMARK 465 GLU D 235 REMARK 465 LEU D 236 REMARK 465 LEU D 237 REMARK 465 GLY D 238 REMARK 465 GLY D 239 REMARK 465 PRO D 240 REMARK 465 SER D 241 REMARK 465 VAL D 242 REMARK 465 PHE D 243 REMARK 465 LEU D 244 REMARK 465 PHE D 245 REMARK 465 PRO D 246 REMARK 465 PRO D 247 REMARK 465 LYS D 248 REMARK 465 PRO D 249 REMARK 465 LYS D 250 REMARK 465 ASP D 251 REMARK 465 THR D 252 REMARK 465 LEU D 253 REMARK 465 MET D 254 REMARK 465 ILE D 255 REMARK 465 SER D 256 REMARK 465 ARG D 257 REMARK 465 THR D 258 REMARK 465 PRO D 259 REMARK 465 GLU D 260 REMARK 465 VAL D 261 REMARK 465 THR D 262 REMARK 465 CYS D 263 REMARK 465 VAL D 264 REMARK 465 VAL D 265 REMARK 465 VAL D 266 REMARK 465 ASP D 267 REMARK 465 VAL D 268 REMARK 465 SER D 269 REMARK 465 HIS D 270 REMARK 465 GLU D 271 REMARK 465 ASP D 272 REMARK 465 PRO D 273 REMARK 465 GLU D 274 REMARK 465 VAL D 275 REMARK 465 LYS D 276 REMARK 465 PHE D 277 REMARK 465 ASN D 278 REMARK 465 TRP D 279 REMARK 465 TYR D 280 REMARK 465 VAL D 281 REMARK 465 ASP D 282 REMARK 465 GLY D 283 REMARK 465 VAL D 284 REMARK 465 GLU D 285 REMARK 465 VAL D 286 REMARK 465 HIS D 287 REMARK 465 ASN D 288 REMARK 465 ALA D 289 REMARK 465 LYS D 290 REMARK 465 THR D 291 REMARK 465 LYS D 292 REMARK 465 PRO D 293 REMARK 465 ARG D 294 REMARK 465 GLU D 295 REMARK 465 GLU D 296 REMARK 465 GLN D 297 REMARK 465 TYR D 298 REMARK 465 ASN D 299 REMARK 465 SER D 300 REMARK 465 THR D 301 REMARK 465 TYR D 302 REMARK 465 ARG D 303 REMARK 465 VAL D 304 REMARK 465 VAL D 305 REMARK 465 SER D 306 REMARK 465 VAL D 307 REMARK 465 LEU D 308 REMARK 465 THR D 309 REMARK 465 VAL D 310 REMARK 465 LEU D 311 REMARK 465 HIS D 312 REMARK 465 GLN D 313 REMARK 465 ASP D 314 REMARK 465 TRP D 315 REMARK 465 LEU D 316 REMARK 465 ASN D 317 REMARK 465 GLY D 318 REMARK 465 LYS D 319 REMARK 465 GLU D 320 REMARK 465 TYR D 321 REMARK 465 LYS D 322 REMARK 465 CYS D 323 REMARK 465 LYS D 324 REMARK 465 VAL D 325 REMARK 465 SER D 326 REMARK 465 ASN D 327 REMARK 465 LYS D 328 REMARK 465 ALA D 329 REMARK 465 LEU D 330 REMARK 465 PRO D 331 REMARK 465 ALA D 332 REMARK 465 PRO D 333 REMARK 465 ILE D 334 REMARK 465 GLU D 335 REMARK 465 LYS D 336 REMARK 465 THR D 337 REMARK 465 ILE D 338 REMARK 465 SER D 339 REMARK 465 LYS D 340 REMARK 465 ALA D 341 REMARK 465 LYS D 342 REMARK 465 GLY D 343 REMARK 465 GLN D 344 REMARK 465 PRO D 345 REMARK 465 ARG D 346 REMARK 465 GLU D 347 REMARK 465 PRO D 348 REMARK 465 GLN D 349 REMARK 465 VAL D 350 REMARK 465 TYR D 351 REMARK 465 THR D 352 REMARK 465 LEU D 353 REMARK 465 PRO D 354 REMARK 465 PRO D 355 REMARK 465 SER D 356 REMARK 465 ARG D 357 REMARK 465 GLU D 358 REMARK 465 GLU D 359 REMARK 465 MET D 360 REMARK 465 THR D 361 REMARK 465 LYS D 362 REMARK 465 ASN D 363 REMARK 465 GLN D 364 REMARK 465 VAL D 365 REMARK 465 SER D 366 REMARK 465 LEU D 367 REMARK 465 THR D 368 REMARK 465 CYS D 369 REMARK 465 LEU D 370 REMARK 465 VAL D 371 REMARK 465 LYS D 372 REMARK 465 GLY D 373 REMARK 465 PHE D 374 REMARK 465 TYR D 375 REMARK 465 PRO D 376 REMARK 465 SER D 377 REMARK 465 ASP D 378 REMARK 465 ILE D 379 REMARK 465 ALA D 380 REMARK 465 VAL D 381 REMARK 465 GLU D 382 REMARK 465 TRP D 383 REMARK 465 GLU D 384 REMARK 465 SER D 385 REMARK 465 ASN D 386 REMARK 465 GLY D 387 REMARK 465 GLN D 388 REMARK 465 PRO D 389 REMARK 465 GLU D 390 REMARK 465 ASN D 391 REMARK 465 ASN D 392 REMARK 465 TYR D 393 REMARK 465 LYS D 394 REMARK 465 THR D 395 REMARK 465 THR D 396 REMARK 465 PRO D 397 REMARK 465 PRO D 398 REMARK 465 VAL D 399 REMARK 465 LEU D 400 REMARK 465 ASP D 401 REMARK 465 SER D 402 REMARK 465 ASP D 403 REMARK 465 GLY D 404 REMARK 465 SER D 405 REMARK 465 PHE D 406 REMARK 465 PHE D 407 REMARK 465 LEU D 408 REMARK 465 TYR D 409 REMARK 465 SER D 410 REMARK 465 LYS D 411 REMARK 465 LEU D 412 REMARK 465 THR D 413 REMARK 465 VAL D 414 REMARK 465 ASP D 415 REMARK 465 LYS D 416 REMARK 465 SER D 417 REMARK 465 ARG D 418 REMARK 465 TRP D 419 REMARK 465 GLN D 420 REMARK 465 GLN D 421 REMARK 465 GLY D 422 REMARK 465 ASN D 423 REMARK 465 VAL D 424 REMARK 465 PHE D 425 REMARK 465 SER D 426 REMARK 465 CYS D 427 REMARK 465 SER D 428 REMARK 465 VAL D 429 REMARK 465 MET D 430 REMARK 465 HIS D 431 REMARK 465 GLU D 432 REMARK 465 ALA D 433 REMARK 465 LEU D 434 REMARK 465 HIS D 435 REMARK 465 ASN D 436 REMARK 465 HIS D 437 REMARK 465 TYR D 438 REMARK 465 THR D 439 REMARK 465 GLN D 440 REMARK 465 LYS D 441 REMARK 465 SER D 442 REMARK 465 LEU D 443 REMARK 465 SER D 444 REMARK 465 LEU D 445 REMARK 465 SER D 446 REMARK 465 PRO D 447 REMARK 465 GLY D 448 REMARK 465 LYS D 449 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OG SER I 63 OG1 THR I 74 2.13 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 PRO C 209 CB PRO C 209 CG -0.561 REMARK 500 PRO C 209 CG PRO C 209 CD -0.312 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO C 209 CA - N - CD ANGL. DEV. = -9.8 DEGREES REMARK 500 PRO C 209 CA - CB - CG ANGL. DEV. = -30.4 DEGREES REMARK 500 PRO C 209 CB - CG - CD ANGL. DEV. = 46.9 DEGREES REMARK 500 PRO C 209 N - CD - CG ANGL. DEV. = -26.3 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 81 71.04 -160.98 REMARK 500 ASP A 178 -167.89 -78.06 REMARK 500 PHE A 220 113.13 -162.53 REMARK 500 LEU A 582 18.38 58.84 REMARK 500 GLN A 613 -163.57 -76.70 REMARK 500 ILE A 666 -54.64 -125.07 REMARK 500 TYR A 674 -11.54 -140.97 REMARK 500 ASN A 710 29.81 -140.35 REMARK 500 ASP A 745 54.52 39.27 REMARK 500 PHE A 855 58.27 38.82 REMARK 500 ASN A 856 54.38 -92.83 REMARK 500 GLN A1071 65.34 60.81 REMARK 500 ASN B 81 71.87 -158.44 REMARK 500 LYS B 304 48.35 38.70 REMARK 500 ALA B 411 149.77 -172.60 REMARK 500 LYS B 535 -60.57 -90.46 REMARK 500 ASN B 710 13.11 -140.39 REMARK 500 LEU B1034 34.48 -98.39 REMARK 500 GLN B1071 62.52 62.06 REMARK 500 ASN C 81 65.44 -160.94 REMARK 500 PHE C 86 -60.27 -98.74 REMARK 500 THR C 124 -60.10 -91.45 REMARK 500 ALA C 292 27.59 -140.13 REMARK 500 THR C 315 -168.79 -124.65 REMARK 500 ARG C 319 148.59 -170.32 REMARK 500 ASN C 334 119.47 -161.36 REMARK 500 ASN C 422 -30.13 -130.85 REMARK 500 TYR C 495 -60.74 -93.80 REMARK 500 LEU C 518 24.69 -141.72 REMARK 500 PRO C 561 1.75 -66.76 REMARK 500 VAL C 729 -54.83 -124.91 REMARK 500 SER E 77 65.09 60.47 REMARK 500 ALA E 103 -54.79 -120.73 REMARK 500 LYS E 149 -164.69 -79.16 REMARK 500 ALA D 92 -175.13 -170.80 REMARK 500 SER D 118 -179.94 -173.05 REMARK 500 ASP D 150 98.13 -163.98 REMARK 500 SER D 179 34.45 -98.77 REMARK 500 SER I 67 -174.00 -170.95 REMARK 500 ASP I 82 35.71 -99.22 REMARK 500 PRO F 44 -179.65 -68.19 REMARK 500 ALA F 84 -169.29 -167.38 REMARK 500 LYS F 170 -60.38 -94.42 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-26262 RELATED DB: EMDB REMARK 900 SARS-COV2 S PROTEIN STRUCTURE IN COMPLEX WITH NEUTRALIZING REMARK 900 MONOCLONAL ANTIBODY 002-55 DBREF 7U0P A 1 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 DBREF 7U0P B 1 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 DBREF 7U0P C 1 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 DBREF 7U0P E 1 449 PDB 7U0P 7U0P 1 449 DBREF 7U0P D 1 449 PDB 7U0P 7U0P 1 449 DBREF 7U0P I 1 215 PDB 7U0P 7U0P 1 215 DBREF 7U0P F 1 215 PDB 7U0P 7U0P 1 215 SEQADV 7U0P GLY A 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 7U0P SER A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 7U0P SER A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 7U0P PRO A 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 7U0P PRO A 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 7U0P PRO A 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 7U0P PRO A 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 7U0P PRO A 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 7U0P PRO A 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 7U0P GLY B 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 7U0P SER B 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 7U0P SER B 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 7U0P PRO B 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 7U0P PRO B 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 7U0P PRO B 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 7U0P PRO B 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 7U0P PRO B 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 7U0P PRO B 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 7U0P GLY C 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 7U0P SER C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 7U0P SER C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 7U0P PRO C 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 7U0P PRO C 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 7U0P PRO C 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 7U0P PRO C 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 7U0P PRO C 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 7U0P PRO C 987 UNP P0DTC2 VAL 987 CONFLICT SEQRES 1 A 1208 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1208 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 A 1208 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 A 1208 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 A 1208 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 A 1208 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 A 1208 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 A 1208 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 A 1208 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 A 1208 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 A 1208 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 A 1208 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 A 1208 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 A 1208 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 A 1208 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 A 1208 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 A 1208 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 A 1208 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 A 1208 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 A 1208 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 A 1208 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 A 1208 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 A 1208 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 A 1208 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 A 1208 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 A 1208 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 A 1208 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 A 1208 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 A 1208 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 A 1208 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 A 1208 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 A 1208 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 A 1208 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 A 1208 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 A 1208 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 A 1208 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 A 1208 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 A 1208 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 A 1208 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 A 1208 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 A 1208 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 A 1208 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 A 1208 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 A 1208 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 A 1208 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 A 1208 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 A 1208 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 A 1208 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 A 1208 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 A 1208 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 A 1208 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 A 1208 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 A 1208 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 54 A 1208 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 A 1208 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 A 1208 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 A 1208 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 A 1208 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 A 1208 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 A 1208 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 A 1208 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 A 1208 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 A 1208 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 A 1208 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 A 1208 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 A 1208 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 A 1208 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 A 1208 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 A 1208 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 A 1208 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 A 1208 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 A 1208 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 A 1208 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 A 1208 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 A 1208 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 A 1208 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 A 1208 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 A 1208 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 A 1208 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 A 1208 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 A 1208 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 A 1208 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 A 1208 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 A 1208 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 A 1208 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 A 1208 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 A 1208 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 A 1208 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 A 1208 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 A 1208 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 A 1208 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 A 1208 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 A 1208 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN SEQRES 1 B 1208 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1208 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 B 1208 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 B 1208 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 B 1208 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 B 1208 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 B 1208 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 B 1208 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 B 1208 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 B 1208 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 B 1208 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 B 1208 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 B 1208 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 B 1208 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 B 1208 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 B 1208 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 B 1208 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 B 1208 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 B 1208 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 B 1208 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 B 1208 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 B 1208 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 B 1208 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 B 1208 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 B 1208 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 B 1208 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 B 1208 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 B 1208 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 B 1208 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 B 1208 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 B 1208 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 B 1208 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 B 1208 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 B 1208 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 B 1208 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 B 1208 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 B 1208 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 B 1208 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 B 1208 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 B 1208 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 B 1208 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 B 1208 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 B 1208 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 B 1208 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 B 1208 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 B 1208 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 B 1208 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 B 1208 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 B 1208 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 B 1208 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 B 1208 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 B 1208 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 B 1208 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 54 B 1208 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 B 1208 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 B 1208 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 B 1208 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 B 1208 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 B 1208 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 B 1208 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 B 1208 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 B 1208 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 B 1208 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 B 1208 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 B 1208 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 B 1208 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 B 1208 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 B 1208 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 B 1208 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 B 1208 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 B 1208 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 B 1208 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 B 1208 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 B 1208 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 B 1208 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 B 1208 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 B 1208 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 B 1208 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 B 1208 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 B 1208 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 B 1208 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 B 1208 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 B 1208 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 B 1208 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 B 1208 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 B 1208 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 B 1208 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 B 1208 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 B 1208 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 B 1208 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 B 1208 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 B 1208 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 B 1208 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN SEQRES 1 C 1208 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 C 1208 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 C 1208 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 C 1208 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 C 1208 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 C 1208 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 C 1208 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 C 1208 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 C 1208 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 C 1208 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 C 1208 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 C 1208 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 C 1208 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 C 1208 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 C 1208 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 C 1208 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 C 1208 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 C 1208 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 C 1208 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 C 1208 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 C 1208 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 C 1208 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 C 1208 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 C 1208 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 C 1208 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 C 1208 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 C 1208 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 C 1208 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 C 1208 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 C 1208 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 C 1208 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 C 1208 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 C 1208 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 C 1208 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 C 1208 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 C 1208 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 C 1208 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 C 1208 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 C 1208 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 C 1208 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 C 1208 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 C 1208 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 C 1208 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 C 1208 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 C 1208 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 C 1208 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 C 1208 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 C 1208 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 C 1208 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 C 1208 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 C 1208 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 C 1208 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 C 1208 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 54 C 1208 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 55 C 1208 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 56 C 1208 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 57 C 1208 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 58 C 1208 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 59 C 1208 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 60 C 1208 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 61 C 1208 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 62 C 1208 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 63 C 1208 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 64 C 1208 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 65 C 1208 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 66 C 1208 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 67 C 1208 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 68 C 1208 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 69 C 1208 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 70 C 1208 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 71 C 1208 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 72 C 1208 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 73 C 1208 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 74 C 1208 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 75 C 1208 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 76 C 1208 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 77 C 1208 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 78 C 1208 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 79 C 1208 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 80 C 1208 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 81 C 1208 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 82 C 1208 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 83 C 1208 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 84 C 1208 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 85 C 1208 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 86 C 1208 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 87 C 1208 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 88 C 1208 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 89 C 1208 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 90 C 1208 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 91 C 1208 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 92 C 1208 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 93 C 1208 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN SEQRES 1 E 449 GLU VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 E 449 PRO GLY GLU SER LEU LYS ILE SER CYS LYS ALA SER GLY SEQRES 3 E 449 TYR ASN PHE ALA TYR TYR TRP ILE GLY TRP VAL ARG GLN SEQRES 4 E 449 MET PRO GLY LYS GLY LEU GLU TRP MET GLY ILE ILE TYR SEQRES 5 E 449 PRO GLY ASP SER ASP THR ARG TYR SER PRO SER PHE GLN SEQRES 6 E 449 GLY GLN VAL THR ILE SER ALA ASP LYS SER ILE SER THR SEQRES 7 E 449 ALA TYR LEU GLN TRP SER SER LEU LYS ALA SER ASP THR SEQRES 8 E 449 ALA MET TYR TYR CYS ALA ARG GLY GLU MET THR ALA VAL SEQRES 9 E 449 PHE GLY ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SEQRES 10 E 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 E 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 E 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 E 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 E 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 E 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 E 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 E 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 E 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 E 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 E 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 E 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 E 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 E 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 E 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 E 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 E 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 E 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 E 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 E 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 E 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 E 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 E 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 E 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 E 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 E 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 D 449 GLU VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 D 449 PRO GLY GLU SER LEU LYS ILE SER CYS LYS ALA SER GLY SEQRES 3 D 449 TYR ASN PHE ALA TYR TYR TRP ILE GLY TRP VAL ARG GLN SEQRES 4 D 449 MET PRO GLY LYS GLY LEU GLU TRP MET GLY ILE ILE TYR SEQRES 5 D 449 PRO GLY ASP SER ASP THR ARG TYR SER PRO SER PHE GLN SEQRES 6 D 449 GLY GLN VAL THR ILE SER ALA ASP LYS SER ILE SER THR SEQRES 7 D 449 ALA TYR LEU GLN TRP SER SER LEU LYS ALA SER ASP THR SEQRES 8 D 449 ALA MET TYR TYR CYS ALA ARG GLY GLU MET THR ALA VAL SEQRES 9 D 449 PHE GLY ASP TYR TRP GLY GLN GLY THR LEU VAL THR VAL SEQRES 10 D 449 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 D 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 D 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 D 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 D 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 D 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 D 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 D 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 D 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 D 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 D 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 D 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 D 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 D 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 D 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 D 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 D 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 D 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 D 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 D 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 D 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 D 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 D 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 D 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 D 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 D 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 I 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 I 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS GLN ALA SER SEQRES 3 I 215 GLN ASP ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 I 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ASP ALA SER SEQRES 5 I 215 ASN LEU GLU THR GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 I 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 215 GLN PRO GLU ASP ILE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 I 215 LYS ILE LEU LEU THR TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 I 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 I 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 I 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 I 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 I 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 I 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 I 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 I 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 I 215 SER PHE ASN ARG GLY GLU CYS SEQRES 1 F 215 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 F 215 SER VAL GLY ASP ARG VAL THR ILE THR CYS GLN ALA SER SEQRES 3 F 215 GLN ASP ILE SER ASN TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 F 215 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ASP ALA SER SEQRES 5 F 215 ASN LEU GLU THR GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 F 215 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 F 215 GLN PRO GLU ASP ILE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 F 215 LYS ILE LEU LEU THR TRP THR PHE GLY GLN GLY THR LYS SEQRES 9 F 215 VAL GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE SEQRES 10 F 215 ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR SEQRES 11 F 215 ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG SEQRES 12 F 215 GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SEQRES 13 F 215 SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER SEQRES 14 F 215 LYS ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SEQRES 15 F 215 SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS SEQRES 16 F 215 GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SEQRES 17 F 215 SER PHE ASN ARG GLY GLU CYS HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG A1308 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG C1308 14 HET NAG B1 1 14 HET NAG B1 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG H 1 14 HET NAG H 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HETNAM NAG N-ACETYL-D-GLUCOSAMINE FORMUL 8 NAG 32(C8 H15 N O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PHE A 338 ASN A 343 1 6 HELIX 3 AA3 TYR A 365 ASN A 370 1 6 HELIX 4 AA4 SER A 383 LEU A 390 5 8 HELIX 5 AA5 ASP A 405 ILE A 410 5 6 HELIX 6 AA6 GLY A 416 ASN A 422 1 7 HELIX 7 AA7 GLY A 502 TYR A 505 5 4 HELIX 8 AA8 ASP A 737 CYS A 743 1 7 HELIX 9 AA9 SER A 746 GLN A 755 1 10 HELIX 10 AB1 SER A 758 ALA A 783 1 26 HELIX 11 AB2 ILE A 818 VAL A 826 1 9 HELIX 12 AB3 THR A 866 SER A 884 1 19 HELIX 13 AB4 TRP A 886 ALA A 890 5 5 HELIX 14 AB5 PRO A 897 ILE A 909 1 13 HELIX 15 AB6 GLN A 913 ASN A 919 1 7 HELIX 16 AB7 ASN A 919 GLY A 932 1 14 HELIX 17 AB8 GLY A 932 SER A 940 1 9 HELIX 18 AB9 LEU A 945 GLN A 965 1 21 HELIX 19 AC1 LEU A 966 SER A 968 5 3 HELIX 20 AC2 VAL A 976 SER A 982 1 7 HELIX 21 AC3 ASP A 985 GLU A 990 1 6 HELIX 22 AC4 GLN A 992 VAL A 1033 1 42 HELIX 23 AC5 THR A 1116 ASP A 1118 5 3 HELIX 24 AC6 PRO A 1140 ASP A 1146 1 7 HELIX 25 AC7 ASP B 294 LEU B 303 1 10 HELIX 26 AC8 CYS B 336 VAL B 341 5 6 HELIX 27 AC9 SER B 349 TRP B 353 5 5 HELIX 28 AD1 TYR B 365 SER B 371 1 7 HELIX 29 AD2 PRO B 384 LEU B 390 5 7 HELIX 30 AD3 ASP B 405 VAL B 407 5 3 HELIX 31 AD4 GLY B 416 ASN B 422 1 7 HELIX 32 AD5 ASN B 616 VAL B 620 5 5 HELIX 33 AD6 PRO B 631 GLY B 639 1 9 HELIX 34 AD7 ASP B 737 ILE B 742 1 6 HELIX 35 AD8 SER B 746 LEU B 754 1 9 HELIX 36 AD9 GLN B 755 GLY B 757 5 3 HELIX 37 AE1 SER B 758 ALA B 771 1 14 HELIX 38 AE2 VAL B 772 ALA B 783 1 12 HELIX 39 AE3 SER B 816 ASN B 824 1 9 HELIX 40 AE4 THR B 866 SER B 884 1 19 HELIX 41 AE5 TRP B 886 ALA B 890 5 5 HELIX 42 AE6 PRO B 897 ILE B 909 1 13 HELIX 43 AE7 VAL B 915 GLU B 918 5 4 HELIX 44 AE8 ASN B 919 LEU B 938 1 20 HELIX 45 AE9 LEU B 945 LYS B 964 1 20 HELIX 46 AF1 GLN B 965 SER B 967 5 3 HELIX 47 AF2 VAL B 976 LEU B 984 1 9 HELIX 48 AF3 ASP B 985 VAL B 1033 1 49 HELIX 49 AF4 THR B 1116 ASP B 1118 5 3 HELIX 50 AF5 LEU B 1141 LYS B 1149 1 9 HELIX 51 AF6 ASP C 294 LEU C 303 1 10 HELIX 52 AF7 PHE C 338 ASN C 343 1 6 HELIX 53 AF8 TYR C 365 SER C 371 1 7 HELIX 54 AF9 PRO C 384 LEU C 390 5 7 HELIX 55 AG1 ASP C 405 ILE C 410 5 6 HELIX 56 AG2 GLY C 416 ASN C 422 1 7 HELIX 57 AG3 ASP C 737 CYS C 743 1 7 HELIX 58 AG4 SER C 746 LEU C 754 1 9 HELIX 59 AG5 GLN C 755 GLY C 757 5 3 HELIX 60 AG6 SER C 758 ALA C 783 1 26 HELIX 61 AG7 SER C 816 VAL C 826 1 11 HELIX 62 AG8 CYS C 851 PHE C 855 5 5 HELIX 63 AG9 THR C 866 GLY C 885 1 20 HELIX 64 AH1 TRP C 886 ALA C 890 5 5 HELIX 65 AH2 PRO C 897 GLY C 908 1 12 HELIX 66 AH3 GLN C 913 ASN C 919 1 7 HELIX 67 AH4 ASN C 919 SER C 940 1 22 HELIX 68 AH5 LEU C 945 GLN C 965 1 21 HELIX 69 AH6 VAL C 976 ARG C 983 1 8 HELIX 70 AH7 ASP C 985 VAL C 1033 1 49 HELIX 71 AH8 PRO C 1140 ASP C 1146 1 7 HELIX 72 AH9 SER E 162 ALA E 164 5 3 HELIX 73 AI1 SER E 193 THR E 197 5 5 HELIX 74 AI2 ASN D 28 TYR D 32 5 5 HELIX 75 AI3 PRO D 62 GLN D 65 5 4 HELIX 76 AI4 SER D 162 ALA D 164 5 3 HELIX 77 AI5 SER D 193 GLN D 198 1 6 HELIX 78 AI6 SER I 122 GLY I 129 1 8 HELIX 79 AI7 LYS I 184 HIS I 190 1 7 HELIX 80 AI8 GLY I 213 CYS I 215 5 3 HELIX 81 AI9 GLN F 79 ILE F 83 5 5 HELIX 82 AJ1 SER F 122 GLY F 129 1 8 HELIX 83 AJ2 LYS F 184 HIS F 190 1 7 HELIX 84 AJ3 GLY F 213 CYS F 215 5 3 SHEET 1 AA1 7 ALA A 27 ASN A 30 0 SHEET 2 AA1 7 ASN A 61 HIS A 66 -1 O TRP A 64 N ALA A 27 SHEET 3 AA1 7 ALA A 264 TYR A 269 -1 O TYR A 265 N PHE A 65 SHEET 4 AA1 7 VAL A 90 SER A 94 -1 N TYR A 91 O GLY A 268 SHEET 5 AA1 7 LEU A 189 ILE A 197 -1 O ARG A 190 N SER A 94 SHEET 6 AA1 7 TYR A 200 THR A 208 -1 O LYS A 206 N GLU A 191 SHEET 7 AA1 7 GLU A 224 PRO A 230 -1 O LEU A 229 N PHE A 201 SHEET 1 AA2 7 VAL A 42 PHE A 43 0 SHEET 2 AA2 7 PHE C 565 ARG C 567 1 O PHE C 565 N PHE A 43 SHEET 3 AA2 7 THR C 573 ARG C 577 -1 O ASP C 574 N GLY C 566 SHEET 4 AA2 7 ILE C 584 THR C 588 -1 O LEU C 585 N VAL C 576 SHEET 5 AA2 7 LEU C 546 GLU C 554 -1 N VAL C 551 O THR C 588 SHEET 6 AA2 7 VAL C 539 PHE C 543 -1 N PHE C 541 O GLY C 548 SHEET 7 AA2 7 SER C 325 ARG C 328 1 N ILE C 326 O ASN C 542 SHEET 1 AA3 3 HIS A 49 PHE A 55 0 SHEET 2 AA3 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 49 SHEET 3 AA3 3 ILE A 285 ASP A 290 -1 O VAL A 289 N LEU A 276 SHEET 1 AA4 3 LEU A 84 PRO A 85 0 SHEET 2 AA4 3 ARG A 237 THR A 240 -1 O PHE A 238 N LEU A 84 SHEET 3 AA4 3 TRP A 104 GLY A 107 -1 N ILE A 105 O GLN A 239 SHEET 1 AA5 3 GLN A 115 ASN A 121 0 SHEET 2 AA5 3 VAL A 126 PHE A 135 -1 O VAL A 127 N VAL A 120 SHEET 3 AA5 3 TYR A 160 SER A 172 -1 O TYR A 170 N ILE A 128 SHEET 1 AA6 4 SER A 151 MET A 153 0 SHEET 2 AA6 4 LEU A 141 HIS A 146 -1 N HIS A 146 O SER A 151 SHEET 3 AA6 4 ALA A 243 ARG A 246 1 O ARG A 246 N VAL A 143 SHEET 4 AA6 4 TRP A 258 THR A 259 -1 O THR A 259 N HIS A 245 SHEET 1 AA7 5 GLY A 311 ARG A 319 0 SHEET 2 AA7 5 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AA7 5 ALA A 609 TYR A 612 -1 O ALA A 609 N ILE A 598 SHEET 4 AA7 5 CYS A 649 ILE A 651 -1 O ILE A 651 N VAL A 610 SHEET 5 AA7 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA8 6 SER A 325 ARG A 328 0 SHEET 2 AA8 6 CYS A 538 PHE A 543 1 O ASN A 540 N ILE A 326 SHEET 3 AA8 6 LEU A 546 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA8 6 ILE A 584 PRO A 589 -1 O ASP A 586 N THR A 553 SHEET 5 AA8 6 THR A 573 ARG A 577 -1 N ASP A 574 O ILE A 587 SHEET 6 AA8 6 PHE A 565 ARG A 567 -1 N GLY A 566 O ASP A 574 SHEET 1 AA9 5 ASN A 354 ILE A 358 0 SHEET 2 AA9 5 ASN A 394 ARG A 403 -1 O ALA A 397 N LYS A 356 SHEET 3 AA9 5 PRO A 507 GLU A 516 -1 O VAL A 510 N PHE A 400 SHEET 4 AA9 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AA9 5 THR A 376 TYR A 380 -1 N THR A 376 O ALA A 435 SHEET 1 AB1 2 CYS A 361 VAL A 362 0 SHEET 2 AB1 2 VAL A 524 CYS A 525 1 O CYS A 525 N CYS A 361 SHEET 1 AB2 2 LEU A 452 ARG A 454 0 SHEET 2 AB2 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AB3 2 TYR A 473 GLN A 474 0 SHEET 2 AB3 2 CYS A 488 TYR A 489 -1 O TYR A 489 N TYR A 473 SHEET 1 AB4 4 GLU A 654 HIS A 655 0 SHEET 2 AB4 4 ILE A 693 THR A 696 1 O ALA A 694 N GLU A 654 SHEET 3 AB4 4 ILE A 670 SER A 673 -1 N CYS A 671 O TYR A 695 SHEET 4 AB4 4 ILE A 664 PRO A 665 -1 N ILE A 664 O ALA A 672 SHEET 1 AB5 3 SER A 711 PRO A 728 0 SHEET 2 AB5 3 GLY A1059 THR A1076 -1 O LYS A1073 N ILE A 714 SHEET 3 AB5 3 TYR A1047 ALA A1056 -1 N MET A1050 O VAL A1065 SHEET 1 AB6 2 THR A 734 VAL A 736 0 SHEET 2 AB6 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AB7 3 ILE A1081 HIS A1083 0 SHEET 2 AB7 3 LYS A1086 PRO A1090 -1 O HIS A1088 N ILE A1081 SHEET 3 AB7 3 THR A1120 VAL A1122 -1 O PHE A1121 N PHE A1089 SHEET 1 AB8 2 VAL A1094 SER A1097 0 SHEET 2 AB8 2 TRP A1102 THR A1105 -1 O THR A1105 N VAL A1094 SHEET 1 AB9 3 ALA B 27 TYR B 28 0 SHEET 2 AB9 3 THR B 63 HIS B 69 -1 O TRP B 64 N ALA B 27 SHEET 3 AB9 3 ARG B 78 PHE B 79 -1 O ARG B 78 N HIS B 69 SHEET 1 AC1 7 ALA B 27 TYR B 28 0 SHEET 2 AC1 7 THR B 63 HIS B 69 -1 O TRP B 64 N ALA B 27 SHEET 3 AC1 7 ALA B 263 GLY B 268 -1 O VAL B 267 N THR B 63 SHEET 4 AC1 7 VAL B 90 SER B 94 -1 N TYR B 91 O GLY B 268 SHEET 5 AC1 7 LEU B 189 ILE B 197 -1 O ARG B 190 N SER B 94 SHEET 6 AC1 7 TYR B 200 THR B 208 -1 O TYR B 204 N VAL B 193 SHEET 7 AC1 7 GLU B 224 PRO B 230 -1 O LEU B 229 N PHE B 201 SHEET 1 AC2 3 LEU B 48 PHE B 55 0 SHEET 2 AC2 3 GLN B 271 TYR B 279 -1 O ARG B 273 N ASP B 53 SHEET 3 AC2 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC3 4 LEU B 84 PRO B 85 0 SHEET 2 AC3 4 ARG B 237 HIS B 245 -1 O PHE B 238 N LEU B 84 SHEET 3 AC3 4 LEU B 141 HIS B 146 1 N LEU B 141 O LEU B 244 SHEET 4 AC3 4 SER B 151 PHE B 157 -1 O MET B 153 N TYR B 144 SHEET 1 AC4 6 LEU B 84 PRO B 85 0 SHEET 2 AC4 6 ARG B 237 HIS B 245 -1 O PHE B 238 N LEU B 84 SHEET 3 AC4 6 ILE B 101 GLY B 107 -1 N ARG B 102 O LEU B 241 SHEET 4 AC4 6 SER B 116 ASN B 121 -1 O LEU B 117 N PHE B 106 SHEET 5 AC4 6 VAL B 126 CYS B 131 -1 O LYS B 129 N LEU B 118 SHEET 6 AC4 6 PHE B 168 SER B 172 -1 O TYR B 170 N ILE B 128 SHEET 1 AC5 5 GLY B 311 ARG B 319 0 SHEET 2 AC5 5 PHE B 592 THR B 599 -1 O GLY B 593 N PHE B 318 SHEET 3 AC5 5 ALA B 609 TYR B 612 -1 O ALA B 609 N ILE B 598 SHEET 4 AC5 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AC5 5 VAL B 642 THR B 645 -1 N THR B 645 O GLY B 648 SHEET 1 AC6 5 SER B 325 ARG B 328 0 SHEET 2 AC6 5 CYS B 538 PHE B 543 1 O ASN B 542 N ARG B 328 SHEET 3 AC6 5 LEU B 546 THR B 553 -1 O GLY B 550 N VAL B 539 SHEET 4 AC6 5 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 5 AC6 5 ALA B 575 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 1 AC7 5 ASN B 354 ILE B 358 0 SHEET 2 AC7 5 ASN B 394 ARG B 403 -1 O ALA B 397 N LYS B 356 SHEET 3 AC7 5 PRO B 507 GLU B 516 -1 O VAL B 510 N PHE B 400 SHEET 4 AC7 5 GLY B 431 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 5 AC7 5 THR B 376 TYR B 380 -1 N LYS B 378 O VAL B 433 SHEET 1 AC8 2 LEU B 452 ARG B 454 0 SHEET 2 AC8 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AC9 2 TYR B 473 GLN B 474 0 SHEET 2 AC9 2 CYS B 488 TYR B 489 -1 O TYR B 489 N TYR B 473 SHEET 1 AD1 4 GLU B 654 HIS B 655 0 SHEET 2 AD1 4 ILE B 692 THR B 696 1 O ALA B 694 N GLU B 654 SHEET 3 AD1 4 ILE B 670 TYR B 674 -1 N SER B 673 O ILE B 693 SHEET 4 AD1 4 ILE B 664 ILE B 666 -1 N ILE B 666 O ILE B 670 SHEET 1 AD2 2 ALA B 701 GLU B 702 0 SHEET 2 AD2 2 GLN C 787 ILE C 788 1 O ILE C 788 N ALA B 701 SHEET 1 AD3 2 SER B 711 ILE B 714 0 SHEET 2 AD3 2 LYS B1073 THR B1076 -1 O LYS B1073 N ILE B 714 SHEET 1 AD4 2 ASN B 717 THR B 719 0 SHEET 2 AD4 2 VAL B1068 ALA B1070 -1 O VAL B1068 N THR B 719 SHEET 1 AD5 3 VAL B 722 PRO B 728 0 SHEET 2 AD5 3 GLY B1059 VAL B1065 -1 O VAL B1060 N LEU B 727 SHEET 3 AD5 3 MET B1050 ALA B1056 -1 N MET B1050 O VAL B1065 SHEET 1 AD6 2 THR B 734 VAL B 736 0 SHEET 2 AD6 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AD7 4 THR B1120 ASN B1125 0 SHEET 2 AD7 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AD7 4 ILE B1081 HIS B1083 -1 N HIS B1083 O LYS B1086 SHEET 4 AD7 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AD8 2 VAL B1094 VAL B1096 0 SHEET 2 AD8 2 PHE B1103 THR B1105 -1 O THR B1105 N VAL B1094 SHEET 1 AD9 7 ALA C 27 SER C 31 0 SHEET 2 AD9 7 SER C 60 HIS C 66 -1 O SER C 60 N SER C 31 SHEET 3 AD9 7 ALA C 264 VAL C 267 -1 O VAL C 267 N THR C 63 SHEET 4 AD9 7 VAL C 90 SER C 94 -1 N ALA C 93 O TYR C 266 SHEET 5 AD9 7 LEU C 189 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AD9 7 TYR C 200 THR C 208 -1 O LYS C 202 N LYS C 195 SHEET 7 AD9 7 GLU C 224 PRO C 230 -1 O LEU C 229 N PHE C 201 SHEET 1 AE1 3 LEU C 48 PHE C 55 0 SHEET 2 AE1 3 GLN C 271 LYS C 278 -1 O PHE C 275 N THR C 51 SHEET 3 AE1 3 ASP C 287 ASP C 290 -1 O VAL C 289 N LEU C 276 SHEET 1 AE2 2 TRP C 104 GLY C 107 0 SHEET 2 AE2 2 ARG C 237 THR C 240 -1 O GLN C 239 N ILE C 105 SHEET 1 AE3 3 SER C 116 ASN C 121 0 SHEET 2 AE3 3 VAL C 126 CYS C 131 -1 O VAL C 127 N VAL C 120 SHEET 3 AE3 3 PHE C 168 SER C 172 -1 O SER C 172 N VAL C 126 SHEET 1 AE4 3 SER C 151 MET C 153 0 SHEET 2 AE4 3 LEU C 141 HIS C 146 -1 N HIS C 146 O SER C 151 SHEET 3 AE4 3 ALA C 243 HIS C 245 1 O LEU C 244 N VAL C 143 SHEET 1 AE5 5 GLY C 311 GLN C 314 0 SHEET 2 AE5 5 VAL C 595 THR C 599 -1 O VAL C 597 N TYR C 313 SHEET 3 AE5 5 ALA C 609 TYR C 612 -1 O ALA C 609 N ILE C 598 SHEET 4 AE5 5 CYS C 649 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AE5 5 VAL C 642 GLN C 644 -1 N PHE C 643 O LEU C 650 SHEET 1 AE6 5 ASN C 354 ILE C 358 0 SHEET 2 AE6 5 ASN C 394 ARG C 403 -1 O VAL C 395 N ILE C 358 SHEET 3 AE6 5 PRO C 507 GLU C 516 -1 O VAL C 510 N PHE C 400 SHEET 4 AE6 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AE6 5 THR C 376 TYR C 380 -1 N THR C 376 O ALA C 435 SHEET 1 AE7 2 CYS C 361 VAL C 362 0 SHEET 2 AE7 2 VAL C 524 CYS C 525 1 O CYS C 525 N CYS C 361 SHEET 1 AE8 2 LEU C 452 ARG C 454 0 SHEET 2 AE8 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE9 2 TYR C 473 GLN C 474 0 SHEET 2 AE9 2 CYS C 488 TYR C 489 -1 O TYR C 489 N TYR C 473 SHEET 1 AF1 4 GLU C 654 HIS C 655 0 SHEET 2 AF1 4 SER C 691 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AF1 4 ILE C 670 GLN C 675 -1 N GLN C 675 O SER C 691 SHEET 4 AF1 4 ILE C 664 GLY C 667 -1 N ILE C 664 O ALA C 672 SHEET 1 AF2 3 SER C 711 PRO C 728 0 SHEET 2 AF2 3 GLY C1059 THR C1076 -1 O ALA C1070 N ASN C 717 SHEET 3 AF2 3 TYR C1047 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AF3 2 THR C 734 VAL C 736 0 SHEET 2 AF3 2 LEU C 858 VAL C 860 -1 O THR C 859 N SER C 735 SHEET 1 AF4 4 THR C1120 VAL C1122 0 SHEET 2 AF4 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AF4 4 ILE C1081 HIS C1083 -1 N ILE C1081 O HIS C1088 SHEET 4 AF4 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AF5 2 VAL C1094 SER C1097 0 SHEET 2 AF5 2 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 1 AF6 4 GLN E 3 GLN E 6 0 SHEET 2 AF6 4 LYS E 19 SER E 25 -1 O LYS E 23 N VAL E 5 SHEET 3 AF6 4 THR E 78 GLN E 82 -1 O LEU E 81 N ILE E 20 SHEET 4 AF6 4 THR E 69 ASP E 73 -1 N SER E 71 O TYR E 80 SHEET 1 AF7 6 GLU E 10 LYS E 12 0 SHEET 2 AF7 6 THR E 113 VAL E 117 1 O LEU E 114 N GLU E 10 SHEET 3 AF7 6 ALA E 92 GLY E 99 -1 N ALA E 92 O VAL E 115 SHEET 4 AF7 6 TRP E 33 GLN E 39 -1 N GLY E 35 O ALA E 97 SHEET 5 AF7 6 LEU E 45 TYR E 52 -1 O ILE E 51 N ILE E 34 SHEET 6 AF7 6 ASP E 57 TYR E 60 -1 O ASP E 57 N TYR E 52 SHEET 1 AF8 4 VAL E 127 LEU E 130 0 SHEET 2 AF8 4 THR E 141 TYR E 151 -1 O LEU E 147 N PHE E 128 SHEET 3 AF8 4 TYR E 182 PRO E 191 -1 O VAL E 190 N ALA E 142 SHEET 4 AF8 4 VAL E 169 THR E 171 -1 N HIS E 170 O VAL E 187 SHEET 1 AF9 4 VAL E 127 LEU E 130 0 SHEET 2 AF9 4 THR E 141 TYR E 151 -1 O LEU E 147 N PHE E 128 SHEET 3 AF9 4 TYR E 182 PRO E 191 -1 O VAL E 190 N ALA E 142 SHEET 4 AF9 4 VAL E 175 LEU E 176 -1 N VAL E 175 O SER E 183 SHEET 1 AG1 3 THR E 157 TRP E 160 0 SHEET 2 AG1 3 TYR E 200 HIS E 206 -1 O ASN E 205 N THR E 157 SHEET 3 AG1 3 THR E 211 VAL E 217 -1 O LYS E 215 N CYS E 202 SHEET 1 AG2 4 GLN D 3 GLN D 6 0 SHEET 2 AG2 4 LYS D 19 SER D 25 -1 O LYS D 23 N VAL D 5 SHEET 3 AG2 4 THR D 78 GLN D 82 -1 O ALA D 79 N CYS D 22 SHEET 4 AG2 4 THR D 69 ASP D 73 -1 N ASP D 73 O THR D 78 SHEET 1 AG3 6 GLU D 10 LYS D 12 0 SHEET 2 AG3 6 THR D 113 VAL D 117 1 O THR D 116 N GLU D 10 SHEET 3 AG3 6 ALA D 92 GLY D 99 -1 N ALA D 92 O VAL D 115 SHEET 4 AG3 6 TRP D 33 GLN D 39 -1 N TRP D 33 O GLY D 99 SHEET 5 AG3 6 LEU D 45 TYR D 52 -1 O ILE D 51 N ILE D 34 SHEET 6 AG3 6 ASP D 57 TYR D 60 -1 O ARG D 59 N ILE D 50 SHEET 1 AG4 4 VAL D 127 LEU D 130 0 SHEET 2 AG4 4 THR D 141 VAL D 148 -1 O GLY D 145 N LEU D 130 SHEET 3 AG4 4 TYR D 182 PRO D 191 -1 O VAL D 190 N ALA D 142 SHEET 4 AG4 4 HIS D 170 THR D 171 -1 N HIS D 170 O VAL D 187 SHEET 1 AG5 4 VAL D 127 LEU D 130 0 SHEET 2 AG5 4 THR D 141 VAL D 148 -1 O GLY D 145 N LEU D 130 SHEET 3 AG5 4 TYR D 182 PRO D 191 -1 O VAL D 190 N ALA D 142 SHEET 4 AG5 4 VAL D 175 LEU D 176 -1 N VAL D 175 O SER D 183 SHEET 1 AG6 3 THR D 157 TRP D 160 0 SHEET 2 AG6 3 TYR D 200 HIS D 206 -1 O ASN D 205 N THR D 157 SHEET 3 AG6 3 THR D 211 VAL D 217 -1 O LYS D 215 N CYS D 202 SHEET 1 AG7 4 MET I 4 SER I 7 0 SHEET 2 AG7 4 VAL I 19 ALA I 25 -1 O THR I 22 N SER I 7 SHEET 3 AG7 4 ASP I 70 ILE I 75 -1 O PHE I 71 N CYS I 23 SHEET 4 AG7 4 PHE I 62 SER I 67 -1 N SER I 63 O THR I 74 SHEET 1 AG8 5 SER I 10 SER I 12 0 SHEET 2 AG8 5 THR I 103 GLU I 106 1 O GLU I 106 N LEU I 11 SHEET 3 AG8 5 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 103 SHEET 4 AG8 5 LEU I 33 GLN I 38 -1 N GLN I 38 O THR I 85 SHEET 5 AG8 5 LYS I 45 ILE I 48 -1 O ILE I 48 N TRP I 35 SHEET 1 AG9 4 SER I 115 PHE I 119 0 SHEET 2 AG9 4 THR I 130 PHE I 140 -1 O LEU I 136 N PHE I 117 SHEET 3 AG9 4 TYR I 174 SER I 183 -1 O LEU I 176 N LEU I 137 SHEET 4 AG9 4 SER I 160 VAL I 164 -1 N SER I 163 O SER I 177 SHEET 1 AH1 4 LEU I 155 GLN I 156 0 SHEET 2 AH1 4 LYS I 146 VAL I 151 -1 N TRP I 149 O GLN I 156 SHEET 3 AH1 4 VAL I 192 THR I 198 -1 O ALA I 194 N LYS I 150 SHEET 4 AH1 4 VAL I 206 ASN I 211 -1 O LYS I 208 N CYS I 195 SHEET 1 AH2 4 MET F 4 SER F 7 0 SHEET 2 AH2 4 VAL F 19 ALA F 25 -1 O THR F 22 N SER F 7 SHEET 3 AH2 4 ASP F 70 ILE F 75 -1 O PHE F 71 N CYS F 23 SHEET 4 AH2 4 PHE F 62 SER F 67 -1 N SER F 65 O THR F 72 SHEET 1 AH3 5 SER F 10 ALA F 13 0 SHEET 2 AH3 5 THR F 103 ILE F 107 1 O GLU F 106 N LEU F 11 SHEET 3 AH3 5 THR F 85 GLN F 90 -1 N TYR F 86 O THR F 103 SHEET 4 AH3 5 LEU F 33 GLN F 38 -1 N GLN F 38 O THR F 85 SHEET 5 AH3 5 LYS F 45 ILE F 48 -1 O ILE F 48 N TRP F 35 SHEET 1 AH4 4 SER F 115 PHE F 119 0 SHEET 2 AH4 4 THR F 130 PHE F 140 -1 O LEU F 136 N PHE F 117 SHEET 3 AH4 4 TYR F 174 SER F 183 -1 O LEU F 176 N LEU F 137 SHEET 4 AH4 4 SER F 160 VAL F 164 -1 N GLN F 161 O THR F 179 SHEET 1 AH5 4 ALA F 154 LEU F 155 0 SHEET 2 AH5 4 LYS F 146 VAL F 151 -1 N VAL F 151 O ALA F 154 SHEET 3 AH5 4 VAL F 192 THR F 198 -1 O ALA F 194 N LYS F 150 SHEET 4 AH5 4 VAL F 206 ASN F 211 -1 O PHE F 210 N TYR F 193 SSBOND 1 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 2 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 3 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 4 CYS A 738 CYS A 760 1555 1555 2.04 SSBOND 5 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 6 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 7 CYS A 1082 CYS A 1126 1555 1555 2.04 SSBOND 8 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 9 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 10 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 11 CYS C 538 CYS C 590 1555 1555 2.04 SSBOND 12 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 13 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 14 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 15 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 16 CYS C 1032 CYS C 1043 1555 1555 2.04 SSBOND 17 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 18 CYS E 22 CYS E 96 1555 1555 2.04 SSBOND 19 CYS D 22 CYS D 96 1555 1555 2.04 SSBOND 20 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 21 CYS I 135 CYS I 195 1555 1555 2.04 SSBOND 22 CYS F 23 CYS F 88 1555 1555 2.04 SSBOND 23 CYS F 135 CYS F 195 1555 1555 2.03 LINK ND2 ASN A 282 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 603 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG A1307 1555 1555 1.45 LINK ND2 ASN A1134 C1 NAG A1308 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1301 1555 1555 1.45 LINK ND2 ASN B 343 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN B 603 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 657 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG B1304 1555 1555 1.45 LINK ND2 ASN B 717 C1 NAG H 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAGB1 1 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 343 C1 NAG C1308 1555 1555 1.44 LINK ND2 ASN C 603 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1304 1555 1555 1.45 LINK ND2 ASN C 709 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG C1306 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG C1307 1555 1555 1.44 LINK O4 NAGB1 1 C1 NAGB1 2 1555 1555 1.45 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.44 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.45 CISPEP 1 PHE E 152 PRO E 153 0 -3.21 CISPEP 2 GLU E 154 PRO E 155 0 -2.96 CISPEP 3 PHE D 152 PRO D 153 0 -2.38 CISPEP 4 GLU D 154 PRO D 155 0 0.56 CISPEP 5 SER I 7 PRO I 8 0 -3.74 CISPEP 6 TYR I 141 PRO I 142 0 1.49 CISPEP 7 SER F 7 PRO F 8 0 -6.04 CISPEP 8 TYR F 141 PRO F 142 0 -1.94 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000