HEADER IMMUNE SYSTEM/VIRUS 10-AUG-21 7V3J TITLE DENV2:F(AB')2-LOCAL COMPND MOL_ID: 1; COMPND 2 MOLECULE: FAB_C10_HEAVY_CHAIN; COMPND 3 CHAIN: H, I; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: FAB_C10_LIGHT_CHAIN; COMPND 7 CHAIN: L, M; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: ENVELOPE PROTEIN E; COMPND 11 CHAIN: B, A, C, P, O, Q; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: SMALL ENVELOPE PROTEIN M; COMPND 15 CHAIN: E, D, F, S, R, T; COMPND 16 SYNONYM: MATRIX PROTEIN; COMPND 17 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS- SOURCE 13 C/1944); SOURCE 14 ORGANISM_COMMON: DENV-2; SOURCE 15 ORGANISM_TAXID: 11065; SOURCE 16 STRAIN: THAILAND/NGS-C/1944; SOURCE 17 EXPRESSION_SYSTEM: AEDES ALBOPICTUS C6/36 CELL DENSOVIRUS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 194675; SOURCE 19 MOL_ID: 4; SOURCE 20 ORGANISM_SCIENTIFIC: DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS- SOURCE 21 C/1944); SOURCE 22 ORGANISM_COMMON: DENV-2; SOURCE 23 ORGANISM_TAXID: 11065; SOURCE 24 STRAIN: THAILAND/NGS-C/1944; SOURCE 25 EXPRESSION_SYSTEM: AEDES ALBOPICTUS C6/36 CELL DENSOVIRUS; SOURCE 26 EXPRESSION_SYSTEM_TAXID: 194675 KEYWDS COMPLEX, ANTIBODY, VIRUS, IMMUNE SYSTEM-VIRUS COMPLEX EXPDTA ELECTRON MICROSCOPY MDLTYP CA ATOMS ONLY, CHAIN H, L, M, I, B, E, A, D, C, F, P, S, O, R, Q, T AUTHOR B.SHU,S.ZHANG,A.K.VICTOR,T.S.NG,S.M.LOK REVDAT 1 29-DEC-21 7V3J 0 JRNL AUTH X.X.LIM,B.SHU,S.ZHANG,A.W.K.TAN,T.S.NG,X.N.LIM,V.S.CHEW, JRNL AUTH 2 J.SHI,G.R.SCREATON,S.M.LOK,G.S.ANAND JRNL TITL HUMAN ANTIBODY C10 NEUTRALIZES BY DIMINISHING ZIKA BUT JRNL TITL 2 ENHANCING DENGUE VIRUS DYNAMICS. JRNL REF CELL V. 184 6067 2021 JRNL REFN ISSN 1097-4172 JRNL PMID 34852238 JRNL DOI 10.1016/J.CELL.2021.11.009 REMARK 2 REMARK 2 RESOLUTION. 4.90 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : UCSF CHIMERA, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 3J27 REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.900 REMARK 3 NUMBER OF PARTICLES : 93432 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 7V3J COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 14-AUG-21. REMARK 100 THE DEPOSITION ID IS D_1300023135. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : DENGUE VIRUS 2 THAILAND/NGS REMARK 245 -C/1944; FAB_C10; DENGUE VIRUS REMARK 245 2 THAILAND/NGS-C/1944 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : NULL REMARK 245 MAXIMUM DEFOCUS (NM) : NULL REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 2500.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXADECAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, M, I, B, E, A, D, C, F, REMARK 350 AND CHAINS: P, S, O, R, Q, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-31681 RELATED DB: EMDB REMARK 900 DENV2:F(AB')2-LOCAL DBREF 7V3J H 1 237 PDB 7V3J 7V3J 1 237 DBREF 7V3J L 1 214 PDB 7V3J 7V3J 1 214 DBREF 7V3J M 1 214 PDB 7V3J 7V3J 1 214 DBREF 7V3J I 1 237 PDB 7V3J 7V3J 1 237 DBREF 7V3J B 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J E 1 72 UNP P14340 POLG_DEN2N 206 277 DBREF 7V3J A 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J D 1 72 UNP P14340 POLG_DEN2N 206 277 DBREF 7V3J C 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J F 1 72 UNP P14340 POLG_DEN2N 206 277 DBREF 7V3J P 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J S 1 72 UNP P14340 POLG_DEN2N 206 277 DBREF 7V3J O 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J R 1 72 UNP P14340 POLG_DEN2N 206 277 DBREF 7V3J Q 1 495 UNP P14340 POLG_DEN2N 281 775 DBREF 7V3J T 1 72 UNP P14340 POLG_DEN2N 206 277 SEQRES 1 H 237 GLU VAL GLN LEU VAL GLU SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 237 PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 H 237 TYR THR PHE THR SER TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 H 237 ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 H 237 ALA GLY ASN GLY ASN THR LYS TYR SER GLN LYS PHE GLN SEQRES 6 H 237 ASP ARG VAL THR ILE THR ARG ASP THR SER ALA SER THR SEQRES 7 H 237 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 H 237 ALA ILE TYR TYR CYS ALA ARG ASP LYS VAL ASP ASP TYR SEQRES 9 H 237 GLY ASP TYR TRP PHE PRO THR LEU TRP TYR PHE ASP TYR SEQRES 10 H 237 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 H 237 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 H 237 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 H 237 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 H 237 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 H 237 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 H 237 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 H 237 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 H 237 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS THR SEQRES 19 H 237 HIS THR CYS SEQRES 1 L 214 SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER PRO SEQRES 2 L 214 GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SER SEQRES 3 L 214 ASP VAL GLY GLY PHE ASN TYR VAL SER TRP PHE GLN GLN SEQRES 4 L 214 HIS PRO GLY LYS ALA PRO LYS LEU MET LEU TYR ASP VAL SEQRES 5 L 214 THR SER ARG PRO SER GLY VAL SER SER ARG PHE SER GLY SEQRES 6 L 214 SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY SEQRES 7 L 214 LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS SER SER SEQRES 8 L 214 HIS THR SER ARG GLY THR TRP VAL PHE GLY GLY GLY THR SEQRES 9 L 214 LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER SEQRES 10 L 214 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA SEQRES 11 L 214 ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR SEQRES 12 L 214 PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER SEQRES 13 L 214 PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS SEQRES 14 L 214 GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER SEQRES 15 L 214 LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER SEQRES 16 L 214 CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR SEQRES 17 L 214 VAL ALA PRO THR GLU CYS SEQRES 1 M 214 SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER PRO SEQRES 2 M 214 GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SER SEQRES 3 M 214 ASP VAL GLY GLY PHE ASN TYR VAL SER TRP PHE GLN GLN SEQRES 4 M 214 HIS PRO GLY LYS ALA PRO LYS LEU MET LEU TYR ASP VAL SEQRES 5 M 214 THR SER ARG PRO SER GLY VAL SER SER ARG PHE SER GLY SEQRES 6 M 214 SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER GLY SEQRES 7 M 214 LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS SER SER SEQRES 8 M 214 HIS THR SER ARG GLY THR TRP VAL PHE GLY GLY GLY THR SEQRES 9 M 214 LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA PRO SER SEQRES 10 M 214 VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU GLN ALA SEQRES 11 M 214 ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP PHE TYR SEQRES 12 M 214 PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SER SER SEQRES 13 M 214 PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SER LYS SEQRES 14 M 214 GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR LEU SER SEQRES 15 M 214 LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER TYR SER SEQRES 16 M 214 CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU LYS THR SEQRES 17 M 214 VAL ALA PRO THR GLU CYS SEQRES 1 I 237 GLU VAL GLN LEU VAL GLU SER GLY ALA GLU VAL LYS LYS SEQRES 2 I 237 PRO GLY ALA SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 I 237 TYR THR PHE THR SER TYR ALA MET HIS TRP VAL ARG GLN SEQRES 4 I 237 ALA PRO GLY GLN ARG LEU GLU TRP MET GLY TRP ILE ASN SEQRES 5 I 237 ALA GLY ASN GLY ASN THR LYS TYR SER GLN LYS PHE GLN SEQRES 6 I 237 ASP ARG VAL THR ILE THR ARG ASP THR SER ALA SER THR SEQRES 7 I 237 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 I 237 ALA ILE TYR TYR CYS ALA ARG ASP LYS VAL ASP ASP TYR SEQRES 9 I 237 GLY ASP TYR TRP PHE PRO THR LEU TRP TYR PHE ASP TYR SEQRES 10 I 237 TRP GLY GLN GLY THR LEU VAL THR VAL SER SER ALA SER SEQRES 11 I 237 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 I 237 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 I 237 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 I 237 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 I 237 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 I 237 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 I 237 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 I 237 VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS THR SEQRES 19 I 237 HIS THR CYS SEQRES 1 B 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 B 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 B 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 B 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 B 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 B 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 B 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 B 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 B 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 B 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 B 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 B 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 B 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 B 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 B 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 B 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 B 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 B 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 B 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 B 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 B 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 B 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 B 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 B 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 B 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 B 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 B 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 B 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 B 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 B 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 B 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 B 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 B 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 B 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 B 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 B 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 B 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 B 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 B 495 ALA SEQRES 1 E 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 E 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 E 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 E 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 E 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 E 72 LEU LEU THR ALA VAL ALA PRO SEQRES 1 A 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 A 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 A 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 A 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 A 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 A 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 A 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 A 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 A 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 A 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 A 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 A 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 A 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 A 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 A 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 A 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 A 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 A 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 A 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 A 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 A 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 A 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 A 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 A 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 A 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 A 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 A 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 A 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 A 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 A 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 A 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 A 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 A 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 A 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 A 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 A 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 A 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 A 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 A 495 ALA SEQRES 1 D 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 D 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 D 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 D 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 D 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 D 72 LEU LEU THR ALA VAL ALA PRO SEQRES 1 C 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 C 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 C 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 C 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 C 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 C 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 C 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 C 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 C 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 C 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 C 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 C 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 C 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 C 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 C 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 C 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 C 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 C 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 C 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 C 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 C 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 C 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 C 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 C 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 C 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 C 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 C 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 C 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 C 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 C 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 C 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 C 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 C 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 C 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 C 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 C 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 C 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 C 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 C 495 ALA SEQRES 1 F 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 F 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 F 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 F 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 F 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 F 72 LEU LEU THR ALA VAL ALA PRO SEQRES 1 P 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 P 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 P 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 P 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 P 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 P 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 P 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 P 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 P 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 P 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 P 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 P 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 P 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 P 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 P 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 P 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 P 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 P 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 P 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 P 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 P 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 P 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 P 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 P 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 P 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 P 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 P 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 P 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 P 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 P 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 P 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 P 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 P 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 P 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 P 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 P 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 P 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 P 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 P 495 ALA SEQRES 1 S 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 S 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 S 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 S 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 S 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 S 72 LEU LEU THR ALA VAL ALA PRO SEQRES 1 O 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 O 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 O 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 O 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 O 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 O 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 O 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 O 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 O 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 O 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 O 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 O 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 O 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 O 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 O 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 O 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 O 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 O 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 O 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 O 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 O 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 O 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 O 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 O 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 O 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 O 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 O 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 O 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 O 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 O 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 O 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 O 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 O 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 O 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 O 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 O 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 O 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 O 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 O 495 ALA SEQRES 1 R 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 R 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 R 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 R 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 R 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 R 72 LEU LEU THR ALA VAL ALA PRO SEQRES 1 Q 495 MET ARG CYS ILE GLY ILE SER ASN ARG ASP PHE VAL GLU SEQRES 2 Q 495 GLY VAL SER GLY GLY SER TRP VAL ASP ILE VAL LEU GLU SEQRES 3 Q 495 HIS GLY SER CYS VAL THR THR MET ALA LYS ASN LYS PRO SEQRES 4 Q 495 THR LEU ASP PHE GLU LEU ILE GLU THR GLU ALA LYS GLN SEQRES 5 Q 495 PRO ALA THR LEU ARG LYS TYR CYS ILE GLU ALA LYS LEU SEQRES 6 Q 495 THR ASN THR THR THR ASP SER ARG CYS PRO THR GLN GLY SEQRES 7 Q 495 GLU PRO SER LEU ASN GLU GLU GLN ASP LYS ARG PHE VAL SEQRES 8 Q 495 CYS LYS HIS SER MET VAL ASP ARG GLY TRP GLY ASN GLY SEQRES 9 Q 495 CYS GLY LEU PHE GLY LYS GLY GLY ILE VAL THR CYS ALA SEQRES 10 Q 495 MET PHE THR CYS LYS LYS ASN MET LYS GLY LYS VAL VAL SEQRES 11 Q 495 GLN PRO GLU ASN LEU GLU TYR THR ILE VAL ILE THR PRO SEQRES 12 Q 495 HIS SER GLY GLU GLU HIS ALA VAL GLY ASN ASP THR GLY SEQRES 13 Q 495 LYS HIS GLY LYS GLU ILE LYS ILE THR PRO GLN SER SER SEQRES 14 Q 495 ILE THR GLU ALA GLU LEU THR GLY TYR GLY THR VAL THR SEQRES 15 Q 495 MET GLU CYS SER PRO ARG THR GLY LEU ASP PHE ASN GLU SEQRES 16 Q 495 MET VAL LEU LEU GLN MET GLU ASN LYS ALA TRP LEU VAL SEQRES 17 Q 495 HIS ARG GLN TRP PHE LEU ASP LEU PRO LEU PRO TRP LEU SEQRES 18 Q 495 PRO GLY ALA ASP THR GLN GLY SER ASN TRP ILE GLN LYS SEQRES 19 Q 495 GLU THR LEU VAL THR PHE LYS ASN PRO HIS ALA LYS LYS SEQRES 20 Q 495 GLN ASP VAL VAL VAL LEU GLY SER GLN GLU GLY ALA MET SEQRES 21 Q 495 HIS THR ALA LEU THR GLY ALA THR GLU ILE GLN MET SER SEQRES 22 Q 495 SER GLY ASN LEU LEU PHE THR GLY HIS LEU LYS CYS ARG SEQRES 23 Q 495 LEU ARG MET ASP LYS LEU GLN LEU LYS GLY MET SER TYR SEQRES 24 Q 495 SER MET CYS THR GLY LYS PHE LYS VAL VAL LYS GLU ILE SEQRES 25 Q 495 ALA GLU THR GLN HIS GLY THR ILE VAL ILE ARG VAL GLN SEQRES 26 Q 495 TYR GLU GLY ASP GLY SER PRO CYS LYS ILE PRO PHE GLU SEQRES 27 Q 495 ILE MET ASP LEU GLU LYS ARG HIS VAL LEU GLY ARG LEU SEQRES 28 Q 495 ILE THR VAL ASN PRO ILE VAL THR GLU LYS ASP SER PRO SEQRES 29 Q 495 VAL ASN ILE GLU ALA GLU PRO PRO PHE GLY ASP SER TYR SEQRES 30 Q 495 ILE ILE ILE GLY VAL GLU PRO GLY GLN LEU LYS LEU ASN SEQRES 31 Q 495 TRP PHE LYS LYS GLY SER SER ILE GLY GLN MET ILE GLU SEQRES 32 Q 495 THR THR MET ARG GLY ALA LYS ARG MET ALA ILE LEU GLY SEQRES 33 Q 495 ASP THR ALA TRP ASP PHE GLY SER LEU GLY GLY VAL PHE SEQRES 34 Q 495 THR SER ILE GLY LYS ALA LEU HIS GLN VAL PHE GLY ALA SEQRES 35 Q 495 ILE TYR GLY ALA ALA PHE SER GLY VAL SER TRP ILE MET SEQRES 36 Q 495 LYS ILE LEU ILE GLY VAL ILE ILE THR TRP ILE GLY MET SEQRES 37 Q 495 ASN SER ARG SER THR SER LEU SER VAL SER LEU VAL LEU SEQRES 38 Q 495 VAL GLY VAL VAL THR LEU TYR LEU GLY VAL MET VAL GLN SEQRES 39 Q 495 ALA SEQRES 1 T 72 SER VAL ALA LEU VAL PRO HIS VAL GLY MET GLY LEU GLU SEQRES 2 T 72 THR ARG THR GLU THR TRP MET SER SER GLU GLY ALA TRP SEQRES 3 T 72 LYS HIS ALA GLN ARG ILE GLU THR TRP ILE LEU ARG HIS SEQRES 4 T 72 PRO GLY PHE THR ILE MET ALA ALA ILE LEU ALA TYR THR SEQRES 5 T 72 ILE GLY THR THR HIS PHE GLN ARG ALA LEU ILE PHE ILE SEQRES 6 T 72 LEU LEU THR ALA VAL ALA PRO CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000