data_7Z1D
# 
_entry.id   7Z1D 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.356 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7Z1D         pdb_00007z1d 10.2210/pdb7z1d/pdb 
WWPDB D_1292120233 ?            ?                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7Z1D 
_pdbx_database_status.recvd_initial_deposition_date   2022-02-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mikolajek, H.'  1 0000-0003-0776-9974 
'Naismith, J.H.' 2 0000-0001-6744-5061 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To be published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of H11-H6 bound to RBD' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mikolajek, H.'  1 0000-0003-0776-9974 
primary 'Naismith, J.H.' 2 0000-0001-6744-5061 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7Z1D 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     62.410 
_cell.length_a_esd                 ? 
_cell.length_b                     65.080 
_cell.length_b_esd                 ? 
_cell.length_c                     82.900 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7Z1D 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Spike protein S1'                       23716.580 1   ? ? ? ? 
2 polymer     man 'H11-H6 nanobody'                        14897.658 1   ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   1   ? ? ? ? 
4 non-polymer syn GLYCEROL                                 92.094    1   ? ? ? ? 
5 water       nat water                                    18.015    312 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ
IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY
FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKHHHHHH
;
;PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ
IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY
FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKHHHHHH
;
EEE ? 
2 'polypeptide(L)' no no 
;QVQLVESGGGLMQAGGSLRLSCAVSGRTFSTAAMGWFRQAPGKEREFVAAIRWSGGSAYYADSVKGRFTISRDKAKNTVY
LQMNSLKYEDTAVYYCAGSKITRSLLSDYATWPYDYWGQGTQVTVSSKHHHHHH
;
;QVQLVESGGGLMQAGGSLRLSCAVSGRTFSTAAMGWFRQAPGKEREFVAAIRWSGGSAYYADSVKGRFTISRDKAKNTVY
LQMNSLKYEDTAVYYCAGSKITRSLLSDYATWPYDYWGQGTQVTVSSKHHHHHH
;
FFF ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   ASN n 
1 3   ILE n 
1 4   THR n 
1 5   ASN n 
1 6   LEU n 
1 7   CYS n 
1 8   PRO n 
1 9   PHE n 
1 10  GLY n 
1 11  GLU n 
1 12  VAL n 
1 13  PHE n 
1 14  ASN n 
1 15  ALA n 
1 16  THR n 
1 17  ARG n 
1 18  PHE n 
1 19  ALA n 
1 20  SER n 
1 21  VAL n 
1 22  TYR n 
1 23  ALA n 
1 24  TRP n 
1 25  ASN n 
1 26  ARG n 
1 27  LYS n 
1 28  ARG n 
1 29  ILE n 
1 30  SER n 
1 31  ASN n 
1 32  CYS n 
1 33  VAL n 
1 34  ALA n 
1 35  ASP n 
1 36  TYR n 
1 37  SER n 
1 38  VAL n 
1 39  LEU n 
1 40  TYR n 
1 41  ASN n 
1 42  SER n 
1 43  ALA n 
1 44  SER n 
1 45  PHE n 
1 46  SER n 
1 47  THR n 
1 48  PHE n 
1 49  LYS n 
1 50  CYS n 
1 51  TYR n 
1 52  GLY n 
1 53  VAL n 
1 54  SER n 
1 55  PRO n 
1 56  THR n 
1 57  LYS n 
1 58  LEU n 
1 59  ASN n 
1 60  ASP n 
1 61  LEU n 
1 62  CYS n 
1 63  PHE n 
1 64  THR n 
1 65  ASN n 
1 66  VAL n 
1 67  TYR n 
1 68  ALA n 
1 69  ASP n 
1 70  SER n 
1 71  PHE n 
1 72  VAL n 
1 73  ILE n 
1 74  ARG n 
1 75  GLY n 
1 76  ASP n 
1 77  GLU n 
1 78  VAL n 
1 79  ARG n 
1 80  GLN n 
1 81  ILE n 
1 82  ALA n 
1 83  PRO n 
1 84  GLY n 
1 85  GLN n 
1 86  THR n 
1 87  GLY n 
1 88  LYS n 
1 89  ILE n 
1 90  ALA n 
1 91  ASP n 
1 92  TYR n 
1 93  ASN n 
1 94  TYR n 
1 95  LYS n 
1 96  LEU n 
1 97  PRO n 
1 98  ASP n 
1 99  ASP n 
1 100 PHE n 
1 101 THR n 
1 102 GLY n 
1 103 CYS n 
1 104 VAL n 
1 105 ILE n 
1 106 ALA n 
1 107 TRP n 
1 108 ASN n 
1 109 SER n 
1 110 ASN n 
1 111 ASN n 
1 112 LEU n 
1 113 ASP n 
1 114 SER n 
1 115 LYS n 
1 116 VAL n 
1 117 GLY n 
1 118 GLY n 
1 119 ASN n 
1 120 TYR n 
1 121 ASN n 
1 122 TYR n 
1 123 LEU n 
1 124 TYR n 
1 125 ARG n 
1 126 LEU n 
1 127 PHE n 
1 128 ARG n 
1 129 LYS n 
1 130 SER n 
1 131 ASN n 
1 132 LEU n 
1 133 LYS n 
1 134 PRO n 
1 135 PHE n 
1 136 GLU n 
1 137 ARG n 
1 138 ASP n 
1 139 ILE n 
1 140 SER n 
1 141 THR n 
1 142 GLU n 
1 143 ILE n 
1 144 TYR n 
1 145 GLN n 
1 146 ALA n 
1 147 GLY n 
1 148 SER n 
1 149 THR n 
1 150 PRO n 
1 151 CYS n 
1 152 ASN n 
1 153 GLY n 
1 154 VAL n 
1 155 GLU n 
1 156 GLY n 
1 157 PHE n 
1 158 ASN n 
1 159 CYS n 
1 160 TYR n 
1 161 PHE n 
1 162 PRO n 
1 163 LEU n 
1 164 GLN n 
1 165 SER n 
1 166 TYR n 
1 167 GLY n 
1 168 PHE n 
1 169 GLN n 
1 170 PRO n 
1 171 THR n 
1 172 ASN n 
1 173 GLY n 
1 174 VAL n 
1 175 GLY n 
1 176 TYR n 
1 177 GLN n 
1 178 PRO n 
1 179 TYR n 
1 180 ARG n 
1 181 VAL n 
1 182 VAL n 
1 183 VAL n 
1 184 LEU n 
1 185 SER n 
1 186 PHE n 
1 187 GLU n 
1 188 LEU n 
1 189 LEU n 
1 190 HIS n 
1 191 ALA n 
1 192 PRO n 
1 193 ALA n 
1 194 THR n 
1 195 VAL n 
1 196 CYS n 
1 197 GLY n 
1 198 PRO n 
1 199 LYS n 
1 200 LYS n 
1 201 SER n 
1 202 THR n 
1 203 ASN n 
1 204 LYS n 
1 205 HIS n 
1 206 HIS n 
1 207 HIS n 
1 208 HIS n 
1 209 HIS n 
1 210 HIS n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   VAL n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  LEU n 
2 12  MET n 
2 13  GLN n 
2 14  ALA n 
2 15  GLY n 
2 16  GLY n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  ALA n 
2 24  VAL n 
2 25  SER n 
2 26  GLY n 
2 27  ARG n 
2 28  THR n 
2 29  PHE n 
2 30  SER n 
2 31  THR n 
2 32  ALA n 
2 33  ALA n 
2 34  MET n 
2 35  GLY n 
2 36  TRP n 
2 37  PHE n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLU n 
2 45  ARG n 
2 46  GLU n 
2 47  PHE n 
2 48  VAL n 
2 49  ALA n 
2 50  ALA n 
2 51  ILE n 
2 52  ARG n 
2 53  TRP n 
2 54  SER n 
2 55  GLY n 
2 56  GLY n 
2 57  SER n 
2 58  ALA n 
2 59  TYR n 
2 60  TYR n 
2 61  ALA n 
2 62  ASP n 
2 63  SER n 
2 64  VAL n 
2 65  LYS n 
2 66  GLY n 
2 67  ARG n 
2 68  PHE n 
2 69  THR n 
2 70  ILE n 
2 71  SER n 
2 72  ARG n 
2 73  ASP n 
2 74  LYS n 
2 75  ALA n 
2 76  LYS n 
2 77  ASN n 
2 78  THR n 
2 79  VAL n 
2 80  TYR n 
2 81  LEU n 
2 82  GLN n 
2 83  MET n 
2 84  ASN n 
2 85  SER n 
2 86  LEU n 
2 87  LYS n 
2 88  TYR n 
2 89  GLU n 
2 90  ASP n 
2 91  THR n 
2 92  ALA n 
2 93  VAL n 
2 94  TYR n 
2 95  TYR n 
2 96  CYS n 
2 97  ALA n 
2 98  GLY n 
2 99  SER n 
2 100 LYS n 
2 101 ILE n 
2 102 THR n 
2 103 ARG n 
2 104 SER n 
2 105 LEU n 
2 106 LEU n 
2 107 SER n 
2 108 ASP n 
2 109 TYR n 
2 110 ALA n 
2 111 THR n 
2 112 TRP n 
2 113 PRO n 
2 114 TYR n 
2 115 ASP n 
2 116 TYR n 
2 117 TRP n 
2 118 GLY n 
2 119 GLN n 
2 120 GLY n 
2 121 THR n 
2 122 GLN n 
2 123 VAL n 
2 124 THR n 
2 125 VAL n 
2 126 SER n 
2 127 SER n 
2 128 LYS n 
2 129 HIS n 
2 130 HIS n 
2 131 HIS n 
2 132 HIS n 
2 133 HIS n 
2 134 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 210 ? ? 'S, 2' ? ? ? ? ? ? 'Severe acute respiratory syndrome coronavirus 2' 2697049 ? ? ? ? ? 
? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 134 ? ? ?      ? ? ? ? ? ? 'Lama glama'                                      9844    ? ? ? ? ? 
? ? ? 'Escherichia coli' 562  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP SPIKE_SARS2 P0DTC2 ? 1 
;PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ
IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY
FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTN
;
330 
2 PDB 7Z1D        7Z1D   ? 2 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 7Z1D EEE 1 ? 203 ? P0DTC2 330 ? 532 ? 330 532 
2 2 7Z1D FFF 1 ? 134 ? 7Z1D   1   ? 134 ? 1   134 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7Z1D LYS EEE 204 ? UNP P0DTC2 ? ? 'expression tag' 533 1 
1 7Z1D HIS EEE 205 ? UNP P0DTC2 ? ? 'expression tag' 534 2 
1 7Z1D HIS EEE 206 ? UNP P0DTC2 ? ? 'expression tag' 535 3 
1 7Z1D HIS EEE 207 ? UNP P0DTC2 ? ? 'expression tag' 536 4 
1 7Z1D HIS EEE 208 ? UNP P0DTC2 ? ? 'expression tag' 537 5 
1 7Z1D HIS EEE 209 ? UNP P0DTC2 ? ? 'expression tag' 538 6 
1 7Z1D HIS EEE 210 ? UNP P0DTC2 ? ? 'expression tag' 539 7 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
GOL non-polymer                  . GLYCEROL                                 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       
92.094  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7Z1D 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            2.18 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         43.58 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            293 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES, pH 7.5 and 20% w/v PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-06-19 
_diffrn_detector.pdbx_frequency               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       7Z1D 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.55 
_reflns.d_resolution_low                               45.04 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     48875 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.5 
_reflns.pdbx_Rmerge_I_obs                              0.083 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.55 
_reflns_shell.d_res_low                                     1.59 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.2 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3509 
_reflns_shell.percent_possible_all                          97.1 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.243 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.2 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.746 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.587 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            0.193 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            0.395 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.494 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.970 
_refine.correlation_coeff_Fo_to_Fc_free          0.963 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 7Z1D 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.550 
_refine.ls_d_res_low                             45.04 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     48825 
_refine.ls_number_reflns_R_free                  2359 
_refine.ls_number_reflns_R_work                  46466 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.271 
_refine.ls_percent_reflns_R_free                 4.832 
_refine.ls_R_factor_all                          0.168 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.1862 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1667 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      6ZBP 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.076 
_refine.pdbx_overall_ESU_R_Free                  0.074 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.900 
_refine.pdbx_solvent_shrinkage_radii             0.900 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.359 
_refine.overall_SU_ML                            0.048 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2525 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         20 
_refine_hist.number_atoms_solvent             312 
_refine_hist.number_atoms_total               2857 
_refine_hist.d_res_high                       1.550 
_refine_hist.d_res_low                        45.04 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006  0.012  2665 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2344 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.315  1.653  3637 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.357  1.580  5442 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 13.735 5.231  346  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 31.213 21.655 139  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 11.952 15.000 402  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 5.575  15.000 2    ? r_dihedral_angle_other_3_deg   ? ? 
'X-RAY DIFFRACTION' ? 14.261 15.000 17   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.066  0.200  336  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.005  0.020  3266 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  628  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.189  0.200  386  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.179  0.200  2178 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.174  0.200  1257 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  1213 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.137  0.200  198  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.208  0.200  15   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.243  0.200  34   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.234  0.200  24   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 0.028  0.200  1    ? r_xyhbond_nbd_other            ? ? 
'X-RAY DIFFRACTION' ? 2.038  2.019  1306 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.022  2.016  1305 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 2.949  3.025  1634 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 2.955  3.028  1635 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.398  2.347  1359 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.397  2.349  1360 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.125  3.391  1993 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.124  3.393  1994 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 6.441  23.840 2935 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.440  23.858 2936 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
'X-RAY DIFFRACTION' 1.550 1.590 . . 148 3354 96.8473 . . . 0.275 . 0.254 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.590 1.634 . . 174 3241 96.9895 . . . 0.234 . 0.217 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.634 1.681 . . 173 3165 97.2611 . . . 0.244 . 0.216 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.681 1.733 . . 186 3080 97.2892 . . . 0.216 . 0.191 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.733 1.790 . . 175 2990 97.8664 . . . 0.213 . 0.184 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.790 1.852 . . 146 2941 98.0623 . . . 0.187 . 0.168 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.852 1.922 . . 135 2840 98.2172 . . . 0.193 . 0.164 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 1.922 2.000 . . 133 2723 97.9088 . . . 0.163 . 0.153 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.000 2.089 . . 138 2624 98.2918 . . . 0.181 . 0.157 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.089 2.191 . . 139 2526 98.9970 . . . 0.153 . 0.155 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.191 2.309 . . 107 2431 98.4102 . . . 0.191 . 0.155 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.309 2.449 . . 98  2298 99.1722 . . . 0.194 . 0.154 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.449 2.618 . . 97  2165 98.8636 . . . 0.203 . 0.166 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.618 2.827 . . 112 2028 99.4886 . . . 0.176 . 0.161 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 2.827 3.096 . . 77  1889 99.4436 . . . 0.222 . 0.166 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 3.096 3.460 . . 59  1730 99.5548 . . . 0.178 . 0.160 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 3.460 3.992 . . 92  1497 99.5614 . . . 0.170 . 0.162 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 3.992 4.881 . . 63  1319 99.9277 . . . 0.140 . 0.136 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 4.881 6.872 . . 65  1020 99.7243 . . . 0.196 . 0.187 . . . . . . . . . . . 
'X-RAY DIFFRACTION' 6.872 8.0   . . 42  605  99.0812 . . . 0.203 . 0.198 . . . . . . . . . . . 
# 
_struct.entry_id                                   7Z1D 
_struct.title                                      'Nanobody H11-H6 bound to RBD' 
_struct.pdbx_structure_determination_methodology   ? 
_struct.pdbx_model_details                         ? 
_struct.pdbx_formula_weight                        ? 
_struct.pdbx_formula_weight_method                 ? 
_struct.pdbx_model_type_details                    ? 
_struct.pdbx_CASP_flag                             N 
# 
_struct_keywords.entry_id        7Z1D 
_struct_keywords.text            'spike, nanobody, high affinity, antiviral protein' 
_struct_keywords.pdbx_keywords   'ANTIVIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 8   ? ASN A 14  ? PRO EEE 337 ASN EEE 343 1 ? 7 
HELX_P HELX_P2  AA2 SER A 20  ? TRP A 24  ? SER EEE 349 TRP EEE 353 5 ? 5 
HELX_P HELX_P3  AA3 TYR A 36  ? ASN A 41  ? TYR EEE 365 ASN EEE 370 1 ? 6 
HELX_P HELX_P4  AA4 SER A 54  ? ASP A 60  ? SER EEE 383 ASP EEE 389 5 ? 7 
HELX_P HELX_P5  AA5 ASP A 76  ? ILE A 81  ? ASP EEE 405 ILE EEE 410 5 ? 6 
HELX_P HELX_P6  AA6 GLY A 87  ? ASN A 93  ? GLY EEE 416 ASN EEE 422 1 ? 7 
HELX_P HELX_P7  AA7 SER A 109 ? SER A 114 ? SER EEE 438 SER EEE 443 1 ? 6 
HELX_P HELX_P8  AA8 GLY A 173 ? TYR A 176 ? GLY EEE 502 TYR EEE 505 5 ? 4 
HELX_P HELX_P9  AA9 ASP B 62  ? LYS B 65  ? ASP FFF 62  LYS FFF 65  5 ? 4 
HELX_P HELX_P10 AB1 LYS B 87  ? THR B 91  ? LYS FFF 87  THR FFF 91  5 ? 5 
HELX_P HELX_P11 AB2 LEU B 105 ? THR B 111 ? LEU FFF 105 THR FFF 111 5 ? 7 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 7   SG  ? ? ? 1_555 A CYS 32  SG ? ? EEE CYS 336 EEE CYS 361 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
disulf2 disulf ?   ? A CYS 50  SG  ? ? ? 1_555 A CYS 103 SG ? ? EEE CYS 379 EEE CYS 432 1_555 ? ? ? ? ? ? ? 2.104 ? ? 
disulf3 disulf ?   ? A CYS 62  SG  ? ? ? 1_555 A CYS 196 SG ? ? EEE CYS 391 EEE CYS 525 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf4 disulf ?   ? A CYS 151 SG  A ? ? 1_555 A CYS 159 SG A ? EEE CYS 480 EEE CYS 488 1_555 ? ? ? ? ? ? ? 2.013 ? ? 
disulf5 disulf ?   ? B CYS 22  SG  ? ? ? 1_555 B CYS 96  SG A ? FFF CYS 22  FFF CYS 96  1_555 ? ? ? ? ? ? ? 2.093 ? ? 
disulf6 disulf ?   ? B CYS 22  SG  ? ? ? 1_555 B CYS 96  SG B ? FFF CYS 22  FFF CYS 96  1_555 ? ? ? ? ? ? ? 2.033 ? ? 
covale1 covale one ? A ASN 14  ND2 ? ? ? 1_555 C NAG .   C1 ? ? EEE ASN 343 EEE NAG 601 1_555 ? ? ? ? ? ? ? 1.431 ? 
N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 4 ? 
AA6 ? 6 ? 
AA7 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN A 25  ? ILE A 29  ? ASN EEE 354 ILE EEE 358 
AA1 2 ASN A 65  ? ARG A 74  ? ASN EEE 394 ARG EEE 403 
AA1 3 PRO A 178 ? GLU A 187 ? PRO EEE 507 GLU EEE 516 
AA1 4 GLY A 102 ? ASN A 108 ? GLY EEE 431 ASN EEE 437 
AA1 5 THR A 47  ? TYR A 51  ? THR EEE 376 TYR EEE 380 
AA2 1 CYS A 32  ? VAL A 33  ? CYS EEE 361 VAL EEE 362 
AA2 2 VAL A 195 ? CYS A 196 ? VAL EEE 524 CYS EEE 525 
AA2 3 CYS A 62  ? PHE A 63  ? CYS EEE 391 PHE EEE 392 
AA3 1 LEU A 123 ? ARG A 125 ? LEU EEE 452 ARG EEE 454 
AA3 2 LEU A 163 ? SER A 165 ? LEU EEE 492 SER EEE 494 
AA4 1 TYR A 144 ? GLN A 145 ? TYR EEE 473 GLN EEE 474 
AA4 2 CYS A 159 ? TYR A 160 ? CYS EEE 488 TYR EEE 489 
AA5 1 GLN B 3   ? GLY B 8   ? GLN FFF 3   GLY FFF 8   
AA5 2 LEU B 18  ? SER B 25  ? LEU FFF 18  SER FFF 25  
AA5 3 THR B 78  ? MET B 83  ? THR FFF 78  MET FFF 83  
AA5 4 PHE B 68  ? ASP B 73  ? PHE FFF 68  ASP FFF 73  
AA6 1 GLY B 10  ? GLN B 13  ? GLY FFF 10  GLN FFF 13  
AA6 2 THR B 121 ? SER B 126 ? THR FFF 121 SER FFF 126 
AA6 3 ALA B 92  ? GLY B 98  ? ALA FFF 92  GLY FFF 98  
AA6 4 ALA B 33  ? GLN B 39  ? ALA FFF 33  GLN FFF 39  
AA6 5 GLU B 46  ? ARG B 52  ? GLU FFF 46  ARG FFF 52  
AA6 6 ALA B 58  ? TYR B 60  ? ALA FFF 58  TYR FFF 60  
AA7 1 GLY B 10  ? GLN B 13  ? GLY FFF 10  GLN FFF 13  
AA7 2 THR B 121 ? SER B 126 ? THR FFF 121 SER FFF 126 
AA7 3 ALA B 92  ? GLY B 98  ? ALA FFF 92  GLY FFF 98  
AA7 4 TYR B 116 ? TRP B 117 ? TYR FFF 116 TRP FFF 117 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 29  ? N ILE EEE 358 O VAL A 66  ? O VAL EEE 395 
AA1 2 3 N ILE A 73  ? N ILE EEE 402 O TYR A 179 ? O TYR EEE 508 
AA1 3 4 O LEU A 184 ? O LEU EEE 513 N CYS A 103 ? N CYS EEE 432 
AA1 4 5 O VAL A 104 ? O VAL EEE 433 N LYS A 49  ? N LYS EEE 378 
AA2 1 2 N CYS A 32  ? N CYS EEE 361 O CYS A 196 ? O CYS EEE 525 
AA2 2 3 O VAL A 195 ? O VAL EEE 524 N PHE A 63  ? N PHE EEE 392 
AA3 1 2 N TYR A 124 ? N TYR EEE 453 O GLN A 164 ? O GLN EEE 493 
AA4 1 2 N TYR A 144 ? N TYR EEE 473 O TYR A 160 ? O TYR EEE 489 
AA5 1 2 N VAL B 5   ? N VAL FFF 5   O ALA B 23  ? O ALA FFF 23  
AA5 2 3 N LEU B 18  ? N LEU FFF 18  O MET B 83  ? O MET FFF 83  
AA5 3 4 O TYR B 80  ? O TYR FFF 80  N SER B 71  ? N SER FFF 71  
AA6 1 2 N GLY B 10  ? N GLY FFF 10  O THR B 124 ? O THR FFF 124 
AA6 2 3 O THR B 121 ? O THR FFF 121 N TYR B 94  ? N TYR FFF 94  
AA6 3 4 O TYR B 95  ? O TYR FFF 95  N PHE B 37  ? N PHE FFF 37  
AA6 4 5 N ARG B 38  ? N ARG FFF 38  O GLU B 46  ? O GLU FFF 46  
AA6 5 6 N ALA B 50  ? N ALA FFF 50  O TYR B 59  ? O TYR FFF 59  
AA7 1 2 N GLY B 10  ? N GLY FFF 10  O THR B 124 ? O THR FFF 124 
AA7 2 3 O THR B 121 ? O THR FFF 121 N TYR B 94  ? N TYR FFF 94  
AA7 3 4 N GLY B 98  ? N GLY FFF 98  O TYR B 116 ? O TYR FFF 116 
# 
_atom_sites.entry_id                    7Z1D 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.016023 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015366 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012063 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
S 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 1.049   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . ASN A 1 5   ? 60.294 11.200 6.018   1.000 63.204 ? 334 ASN EEE N   1 ? 
ATOM   2    C CA  . ASN A 1 5   ? 60.893 12.307 5.213   1.000 56.896 ? 334 ASN EEE CA  1 ? 
ATOM   3    C C   . ASN A 1 5   ? 61.542 11.739 3.939   1.000 47.988 ? 334 ASN EEE C   1 ? 
ATOM   4    O O   . ASN A 1 5   ? 62.489 12.360 3.438   1.000 41.161 ? 334 ASN EEE O   1 ? 
ATOM   5    C CB  . ASN A 1 5   ? 61.885 13.123 6.049   1.000 56.967 ? 334 ASN EEE CB  1 ? 
ATOM   6    C CG  . ASN A 1 5   ? 62.985 12.275 6.654   1.000 60.923 ? 334 ASN EEE CG  1 ? 
ATOM   7    O OD1 . ASN A 1 5   ? 63.082 11.081 6.375   1.000 56.111 ? 334 ASN EEE OD1 1 ? 
ATOM   8    N ND2 . ASN A 1 5   ? 63.818 12.882 7.485   1.000 66.232 ? 334 ASN EEE ND2 1 ? 
ATOM   9    N N   . LEU A 1 6   ? 61.066 10.594 3.441   1.000 41.691 ? 335 LEU EEE N   1 ? 
ATOM   10   C CA  . LEU A 1 6   ? 61.348 10.120 2.061   1.000 41.981 ? 335 LEU EEE CA  1 ? 
ATOM   11   C C   . LEU A 1 6   ? 60.563 11.029 1.110   1.000 33.516 ? 335 LEU EEE C   1 ? 
ATOM   12   O O   . LEU A 1 6   ? 59.367 11.238 1.365   1.000 35.596 ? 335 LEU EEE O   1 ? 
ATOM   13   C CB  . LEU A 1 6   ? 60.918 8.654  1.935   1.000 46.395 ? 335 LEU EEE CB  1 ? 
ATOM   14   C CG  . LEU A 1 6   ? 61.363 7.911  0.673   1.000 53.635 ? 335 LEU EEE CG  1 ? 
ATOM   15   C CD1 . LEU A 1 6   ? 62.820 8.194  0.329   1.000 54.509 ? 335 LEU EEE CD1 1 ? 
ATOM   16   C CD2 . LEU A 1 6   ? 61.141 6.414  0.832   1.000 55.574 ? 335 LEU EEE CD2 1 ? 
ATOM   17   N N   . CYS A 1 7   ? 61.202 11.587 0.081   1.000 31.961 ? 336 CYS EEE N   1 ? 
ATOM   18   C CA  . CYS A 1 7   ? 60.523 12.523 -0.855  1.000 29.873 ? 336 CYS EEE CA  1 ? 
ATOM   19   C C   . CYS A 1 7   ? 59.356 11.795 -1.513  1.000 27.384 ? 336 CYS EEE C   1 ? 
ATOM   20   O O   . CYS A 1 7   ? 59.518 10.661 -1.954  1.000 28.763 ? 336 CYS EEE O   1 ? 
ATOM   21   C CB  . CYS A 1 7   ? 61.472 13.078 -1.906  1.000 30.991 ? 336 CYS EEE CB  1 ? 
ATOM   22   S SG  . CYS A 1 7   ? 62.758 14.154 -1.222  1.000 32.100 ? 336 CYS EEE SG  1 ? 
ATOM   23   N N   . PRO A 1 8   ? 58.158 12.422 -1.588  1.000 29.078 ? 337 PRO EEE N   1 ? 
ATOM   24   C CA  . PRO A 1 8   ? 56.961 11.766 -2.112  1.000 30.699 ? 337 PRO EEE CA  1 ? 
ATOM   25   C C   . PRO A 1 8   ? 56.901 11.695 -3.647  1.000 30.261 ? 337 PRO EEE C   1 ? 
ATOM   26   O O   . PRO A 1 8   ? 55.899 12.098 -4.222  1.000 29.499 ? 337 PRO EEE O   1 ? 
ATOM   27   C CB  . PRO A 1 8   ? 55.845 12.668 -1.560  1.000 32.790 ? 337 PRO EEE CB  1 ? 
ATOM   28   C CG  . PRO A 1 8   ? 56.459 14.043 -1.604  1.000 33.395 ? 337 PRO EEE CG  1 ? 
ATOM   29   C CD  . PRO A 1 8   ? 57.888 13.806 -1.158  1.000 30.694 ? 337 PRO EEE CD  1 ? 
ATOM   30   N N   . PHE A 1 9   ? 57.943 11.152 -4.282  1.000 26.775 ? 338 PHE EEE N   1 ? 
ATOM   31   C CA  . PHE A 1 9   ? 57.984 11.001 -5.762  1.000 24.897 ? 338 PHE EEE CA  1 ? 
ATOM   32   C C   . PHE A 1 9   ? 56.886 10.021 -6.197  1.000 25.265 ? 338 PHE EEE C   1 ? 
ATOM   33   O O   . PHE A 1 9   ? 56.320 10.205 -7.294  1.000 24.852 ? 338 PHE EEE O   1 ? 
ATOM   34   C CB  . PHE A 1 9   ? 59.378 10.590 -6.249  1.000 26.666 ? 338 PHE EEE CB  1 ? 
ATOM   35   C CG  . PHE A 1 9   ? 60.386 11.713 -6.237  1.000 30.903 ? 338 PHE EEE CG  1 ? 
ATOM   36   C CD1 . PHE A 1 9   ? 60.131 12.906 -6.898  1.000 33.318 ? 338 PHE EEE CD1 1 ? 
ATOM   37   C CD2 . PHE A 1 9   ? 61.591 11.580 -5.566  1.000 38.451 ? 338 PHE EEE CD2 1 ? 
ATOM   38   C CE1 . PHE A 1 9   ? 61.053 13.942 -6.880  1.000 35.527 ? 338 PHE EEE CE1 1 ? 
ATOM   39   C CE2 . PHE A 1 9   ? 62.512 12.617 -5.549  1.000 40.048 ? 338 PHE EEE CE2 1 ? 
ATOM   40   C CZ  . PHE A 1 9   ? 62.241 13.795 -6.203  1.000 38.179 ? 338 PHE EEE CZ  1 ? 
ATOM   41   N N   . GLY A 1 10  ? 56.562 9.034  -5.359  1.000 24.806 ? 339 GLY EEE N   1 ? 
ATOM   42   C CA  . GLY A 1 10  ? 55.454 8.093  -5.616  1.000 25.237 ? 339 GLY EEE CA  1 ? 
ATOM   43   C C   . GLY A 1 10  ? 54.152 8.825  -5.911  1.000 24.351 ? 339 GLY EEE C   1 ? 
ATOM   44   O O   . GLY A 1 10  ? 53.469 8.454  -6.884  1.000 24.694 ? 339 GLY EEE O   1 ? 
ATOM   45   N N   . GLU A 1 11  ? 53.819 9.846  -5.118  1.000 24.052 ? 340 GLU EEE N   1 ? 
ATOM   46   C CA  . GLU A 1 11  ? 52.564 10.639 -5.243  1.000 25.938 ? 340 GLU EEE CA  1 ? 
ATOM   47   C C   . GLU A 1 11  ? 52.495 11.282 -6.632  1.000 26.015 ? 340 GLU EEE C   1 ? 
ATOM   48   O O   . GLU A 1 11  ? 51.383 11.446 -7.147  1.000 26.119 ? 340 GLU EEE O   1 ? 
ATOM   49   C CB  . GLU A 1 11  ? 52.487 11.755 -4.199  1.000 29.863 ? 340 GLU EEE CB  1 ? 
ATOM   50   C CG  . GLU A 1 11  ? 52.337 11.262 -2.772  1.000 35.803 ? 340 GLU EEE CG  1 ? 
ATOM   51   C CD  . GLU A 1 11  ? 52.281 12.364 -1.724  1.000 43.867 ? 340 GLU EEE CD  1 ? 
ATOM   52   O OE1 . GLU A 1 11  ? 52.300 13.558 -2.107  1.000 44.057 ? 340 GLU EEE OE1 1 ? 
ATOM   53   O OE2 . GLU A 1 11  ? 52.232 12.025 -0.519  1.000 52.564 ? 340 GLU EEE OE2 1 ? 
ATOM   54   N N   . VAL A 1 12  ? 53.646 11.644 -7.200  1.000 21.539 ? 341 VAL EEE N   1 ? 
ATOM   55   C CA  . VAL A 1 12  ? 53.730 12.309 -8.534  1.000 21.551 ? 341 VAL EEE CA  1 ? 
ATOM   56   C C   . VAL A 1 12  ? 53.662 11.235 -9.628  1.000 19.287 ? 341 VAL EEE C   1 ? 
ATOM   57   O O   . VAL A 1 12  ? 52.765 11.295 -10.493 1.000 20.166 ? 341 VAL EEE O   1 ? 
ATOM   58   C CB  . VAL A 1 12  ? 55.014 13.145 -8.656  1.000 23.245 ? 341 VAL EEE CB  1 ? 
ATOM   59   C CG1 . VAL A 1 12  ? 55.137 13.764 -10.039 1.000 23.909 ? 341 VAL EEE CG1 1 ? 
ATOM   60   C CG2 . VAL A 1 12  ? 55.100 14.209 -7.571  1.000 27.404 ? 341 VAL EEE CG2 1 ? 
ATOM   61   N N   . PHE A 1 13  ? 54.587 10.280 -9.604  1.000 17.844 ? 342 PHE EEE N   1 ? 
ATOM   62   C CA  . PHE A 1 13  ? 54.753 9.314  -10.719 1.000 17.349 ? 342 PHE EEE CA  1 ? 
ATOM   63   C C   . PHE A 1 13  ? 53.570 8.347  -10.752 1.000 18.944 ? 342 PHE EEE C   1 ? 
ATOM   64   O O   . PHE A 1 13  ? 53.176 7.932  -11.845 1.000 20.449 ? 342 PHE EEE O   1 ? 
ATOM   65   C CB  . PHE A 1 13  ? 56.077 8.562  -10.602 1.000 17.756 ? 342 PHE EEE CB  1 ? 
ATOM   66   C CG  . PHE A 1 13  ? 57.256 9.395  -11.021 1.000 17.424 ? 342 PHE EEE CG  1 ? 
ATOM   67   C CD1 . PHE A 1 13  ? 57.850 10.278 -10.134 1.000 17.753 ? 342 PHE EEE CD1 1 ? 
ATOM   68   C CD2 . PHE A 1 13  ? 57.718 9.353  -12.323 1.000 16.693 ? 342 PHE EEE CD2 1 ? 
ATOM   69   C CE1 . PHE A 1 13  ? 58.915 11.067 -10.528 1.000 18.324 ? 342 PHE EEE CE1 1 ? 
ATOM   70   C CE2 . PHE A 1 13  ? 58.786 10.141 -12.715 1.000 17.805 ? 342 PHE EEE CE2 1 ? 
ATOM   71   C CZ  . PHE A 1 13  ? 59.377 10.998 -11.824 1.000 16.894 ? 342 PHE EEE CZ  1 ? 
ATOM   72   N N   . ASN A 1 14  ? 53.016 8.021  -9.585  1.000 19.412 ? 343 ASN EEE N   1 ? 
ATOM   73   C CA  . ASN A 1 14  ? 51.983 6.966  -9.453  1.000 20.202 ? 343 ASN EEE CA  1 ? 
ATOM   74   C C   . ASN A 1 14  ? 50.610 7.574  -9.157  1.000 21.116 ? 343 ASN EEE C   1 ? 
ATOM   75   O O   . ASN A 1 14  ? 49.701 6.804  -8.803  1.000 22.201 ? 343 ASN EEE O   1 ? 
ATOM   76   C CB  . ASN A 1 14  ? 52.423 5.938  -8.411  1.000 21.820 ? 343 ASN EEE CB  1 ? 
ATOM   77   C CG  . ASN A 1 14  ? 53.484 5.002  -8.940  1.000 23.552 ? 343 ASN EEE CG  1 ? 
ATOM   78   O OD1 . ASN A 1 14  ? 53.520 4.717  -10.134 1.000 24.473 ? 343 ASN EEE OD1 1 ? 
ATOM   79   N ND2 . ASN A 1 14  ? 54.351 4.529  -8.060  1.000 23.242 ? 343 ASN EEE ND2 1 ? 
ATOM   80   N N   . ALA A 1 15  ? 50.434 8.882  -9.367  1.000 20.351 ? 344 ALA EEE N   1 ? 
ATOM   81   C CA  . ALA A 1 15  ? 49.112 9.548  -9.284  1.000 20.468 ? 344 ALA EEE CA  1 ? 
ATOM   82   C C   . ALA A 1 15  ? 48.101 8.795  -10.162 1.000 21.115 ? 344 ALA EEE C   1 ? 
ATOM   83   O O   . ALA A 1 15  ? 48.441 8.433  -11.298 1.000 21.819 ? 344 ALA EEE O   1 ? 
ATOM   84   C CB  . ALA A 1 15  ? 49.225 10.996 -9.685  1.000 18.681 ? 344 ALA EEE CB  1 ? 
ATOM   85   N N   . THR A 1 16  ? 46.885 8.567  -9.662  1.000 24.750 ? 345 THR EEE N   1 ? 
ATOM   86   C CA  . THR A 1 16  ? 45.797 7.916  -10.439 1.000 27.336 ? 345 THR EEE CA  1 ? 
ATOM   87   C C   . THR A 1 16  ? 45.488 8.758  -11.675 1.000 26.032 ? 345 THR EEE C   1 ? 
ATOM   88   O O   . THR A 1 16  ? 45.414 8.192  -12.782 1.000 27.758 ? 345 THR EEE O   1 ? 
ATOM   89   C CB  . THR A 1 16  ? 44.502 7.780  -9.632  1.000 30.242 ? 345 THR EEE CB  1 ? 
ATOM   90   O OG1 . THR A 1 16  ? 44.847 7.159  -8.393  1.000 39.107 ? 345 THR EEE OG1 1 ? 
ATOM   91   C CG2 . THR A 1 16  ? 43.448 6.980  -10.367 1.000 32.710 ? 345 THR EEE CG2 1 ? 
ATOM   92   N N   . ARG A 1 17  ? 45.338 10.062 -11.448 1.000 27.095 ? 346 ARG EEE N   1 ? 
ATOM   93   C CA  . ARG A 1 17  ? 44.907 11.063 -12.448 1.000 25.406 ? 346 ARG EEE CA  1 ? 
ATOM   94   C C   . ARG A 1 17  ? 46.097 11.962 -12.790 1.000 20.058 ? 346 ARG EEE C   1 ? 
ATOM   95   O O   . ARG A 1 17  ? 46.833 12.346 -11.874 1.000 21.872 ? 346 ARG EEE O   1 ? 
ATOM   96   C CB  . ARG A 1 17  ? 43.740 11.883 -11.897 1.000 27.548 ? 346 ARG EEE CB  1 ? 
ATOM   97   C CG  . ARG A 1 17  ? 42.445 11.099 -11.745 1.000 38.103 ? 346 ARG EEE CG  1 ? 
ATOM   98   C CD  . ARG A 1 17  ? 41.257 12.033 -11.613 1.000 47.995 ? 346 ARG EEE CD  1 ? 
ATOM   99   N NE  . ARG A 1 17  ? 41.331 12.837 -10.398 1.000 61.325 ? 346 ARG EEE NE  1 ? 
ATOM   100  C CZ  . ARG A 1 17  ? 40.789 14.046 -10.236 1.000 71.280 ? 346 ARG EEE CZ  1 ? 
ATOM   101  N NH1 . ARG A 1 17  ? 40.130 14.635 -11.223 1.000 73.306 ? 346 ARG EEE NH1 1 ? 
ATOM   102  N NH2 . ARG A 1 17  ? 40.923 14.673 -9.079  1.000 73.706 ? 346 ARG EEE NH2 1 ? 
ATOM   103  N N   . PHE A 1 18  ? 46.270 12.270 -14.077 1.000 19.433 ? 347 PHE EEE N   1 ? 
ATOM   104  C CA  . PHE A 1 18  ? 47.271 13.245 -14.572 1.000 16.520 ? 347 PHE EEE CA  1 ? 
ATOM   105  C C   . PHE A 1 18  ? 46.541 14.426 -15.211 1.000 14.651 ? 347 PHE EEE C   1 ? 
ATOM   106  O O   . PHE A 1 18  ? 45.415 14.263 -15.709 1.000 15.467 ? 347 PHE EEE O   1 ? 
ATOM   107  C CB  . PHE A 1 18  ? 48.236 12.596 -15.568 1.000 15.840 ? 347 PHE EEE CB  1 ? 
ATOM   108  C CG  . PHE A 1 18  ? 49.529 12.100 -14.973 1.000 16.515 ? 347 PHE EEE CG  1 ? 
ATOM   109  C CD1 . PHE A 1 18  ? 49.531 11.247 -13.878 1.000 18.877 ? 347 PHE EEE CD1 1 ? 
ATOM   110  C CD2 . PHE A 1 18  ? 50.749 12.497 -15.500 1.000 16.192 ? 347 PHE EEE CD2 1 ? 
ATOM   111  C CE1 . PHE A 1 18  ? 50.728 10.810 -13.325 1.000 17.752 ? 347 PHE EEE CE1 1 ? 
ATOM   112  C CE2 . PHE A 1 18  ? 51.942 12.048 -14.953 1.000 18.159 ? 347 PHE EEE CE2 1 ? 
ATOM   113  C CZ  . PHE A 1 18  ? 51.927 11.207 -13.865 1.000 17.655 ? 347 PHE EEE CZ  1 ? 
ATOM   114  N N   . ALA A 1 19  ? 47.191 15.585 -15.183 1.000 15.081 ? 348 ALA EEE N   1 ? 
ATOM   115  C CA  . ALA A 1 19  ? 46.697 16.840 -15.793 1.000 14.277 ? 348 ALA EEE CA  1 ? 
ATOM   116  C C   . ALA A 1 19  ? 46.737 16.774 -17.320 1.000 14.429 ? 348 ALA EEE C   1 ? 
ATOM   117  O O   . ALA A 1 19  ? 47.634 16.124 -17.896 1.000 14.222 ? 348 ALA EEE O   1 ? 
ATOM   118  C CB  . ALA A 1 19  ? 47.523 17.994 -15.304 1.000 15.580 ? 348 ALA EEE CB  1 ? 
ATOM   119  N N   . SER A 1 20  ? 45.818 17.494 -17.961 1.000 13.703 ? 349 SER EEE N   1 ? 
ATOM   120  C CA  . SER A 1 20  ? 45.988 17.946 -19.361 1.000 12.856 ? 349 SER EEE CA  1 ? 
ATOM   121  C C   . SER A 1 20  ? 47.231 18.831 -19.412 1.000 14.107 ? 349 SER EEE C   1 ? 
ATOM   122  O O   . SER A 1 20  ? 47.467 19.601 -18.457 1.000 14.528 ? 349 SER EEE O   1 ? 
ATOM   123  C CB  . SER A 1 20  ? 44.809 18.707 -19.866 1.000 12.623 ? 349 SER EEE CB  1 ? 
ATOM   124  O OG  . SER A 1 20  ? 43.703 17.859 -20.122 1.000 15.139 ? 349 SER EEE OG  1 ? 
ATOM   125  N N   . VAL A 1 21  ? 47.957 18.789 -20.520 1.000 13.069 ? 350 VAL EEE N   1 ? 
ATOM   126  C CA  . VAL A 1 21  ? 49.224 19.550 -20.668 1.000 13.674 ? 350 VAL EEE CA  1 ? 
ATOM   127  C C   . VAL A 1 21  ? 48.979 21.061 -20.548 1.000 14.302 ? 350 VAL EEE C   1 ? 
ATOM   128  O O   . VAL A 1 21  ? 49.822 21.719 -19.945 1.000 15.087 ? 350 VAL EEE O   1 ? 
ATOM   129  C CB  . VAL A 1 21  ? 49.950 19.159 -21.966 1.000 13.725 ? 350 VAL EEE CB  1 ? 
ATOM   130  C CG1 . VAL A 1 21  ? 49.139 19.496 -23.215 1.000 14.663 ? 350 VAL EEE CG1 1 ? 
ATOM   131  C CG2 . VAL A 1 21  ? 51.345 19.766 -22.013 1.000 13.629 ? 350 VAL EEE CG2 1 ? 
ATOM   132  N N   . TYR A 1 22  ? 47.874 21.612 -21.055 1.000 14.611 ? 351 TYR EEE N   1 ? 
ATOM   133  C CA  . TYR A 1 22  ? 47.635 23.080 -20.976 1.000 14.562 ? 351 TYR EEE CA  1 ? 
ATOM   134  C C   . TYR A 1 22  ? 47.473 23.480 -19.502 1.000 13.837 ? 351 TYR EEE C   1 ? 
ATOM   135  O O   . TYR A 1 22  ? 47.810 24.628 -19.145 1.000 15.664 ? 351 TYR EEE O   1 ? 
ATOM   136  C CB  . TYR A 1 22  ? 46.439 23.503 -21.836 1.000 14.703 ? 351 TYR EEE CB  1 ? 
ATOM   137  C CG  . TYR A 1 22  ? 45.104 23.325 -21.165 1.000 14.876 ? 351 TYR EEE CG  1 ? 
ATOM   138  C CD1 . TYR A 1 22  ? 44.446 22.105 -21.202 1.000 14.857 ? 351 TYR EEE CD1 1 ? 
ATOM   139  C CD2 . TYR A 1 22  ? 44.527 24.352 -20.432 1.000 16.214 ? 351 TYR EEE CD2 1 ? 
ATOM   140  C CE1 . TYR A 1 22  ? 43.240 21.912 -20.551 1.000 15.913 ? 351 TYR EEE CE1 1 ? 
ATOM   141  C CE2 . TYR A 1 22  ? 43.322 24.172 -19.774 1.000 17.356 ? 351 TYR EEE CE2 1 ? 
ATOM   142  C CZ  . TYR A 1 22  ? 42.679 22.949 -19.830 1.000 17.393 ? 351 TYR EEE CZ  1 ? 
ATOM   143  O OH  . TYR A 1 22  ? 41.484 22.777 -19.192 1.000 23.289 ? 351 TYR EEE OH  1 ? 
ATOM   144  N N   . ALA A 1 23  ? 46.989 22.555 -18.672 1.000 13.633 ? 352 ALA EEE N   1 ? 
ATOM   145  C CA  . ALA A 1 23  ? 46.713 22.775 -17.234 1.000 13.798 ? 352 ALA EEE CA  1 ? 
ATOM   146  C C   . ALA A 1 23  ? 47.694 21.953 -16.399 1.000 14.422 ? 352 ALA EEE C   1 ? 
ATOM   147  O O   . ALA A 1 23  ? 47.301 21.424 -15.335 1.000 15.709 ? 352 ALA EEE O   1 ? 
ATOM   148  C CB  . ALA A 1 23  ? 45.283 22.427 -16.941 1.000 15.031 ? 352 ALA EEE CB  1 ? 
ATOM   149  N N   . TRP A 1 24  ? 48.940 21.885 -16.855 1.000 13.772 ? 353 TRP EEE N   1 ? 
ATOM   150  C CA  . TRP A 1 24  ? 49.988 21.035 -16.242 1.000 14.325 ? 353 TRP EEE CA  1 ? 
ATOM   151  C C   . TRP A 1 24  ? 50.097 21.287 -14.735 1.000 14.300 ? 353 TRP EEE C   1 ? 
ATOM   152  O O   . TRP A 1 24  ? 50.019 22.445 -14.284 1.000 15.653 ? 353 TRP EEE O   1 ? 
ATOM   153  C CB  . TRP A 1 24  ? 51.337 21.223 -16.938 1.000 14.522 ? 353 TRP EEE CB  1 ? 
ATOM   154  C CG  . TRP A 1 24  ? 51.827 22.635 -17.048 1.000 14.373 ? 353 TRP EEE CG  1 ? 
ATOM   155  C CD1 . TRP A 1 24  ? 51.602 23.528 -18.058 1.000 13.539 ? 353 TRP EEE CD1 1 ? 
ATOM   156  C CD2 . TRP A 1 24  ? 52.739 23.274 -16.146 1.000 14.367 ? 353 TRP EEE CD2 1 ? 
ATOM   157  N NE1 . TRP A 1 24  ? 52.295 24.685 -17.831 1.000 14.744 ? 353 TRP EEE NE1 1 ? 
ATOM   158  C CE2 . TRP A 1 24  ? 53.000 24.559 -16.663 1.000 14.956 ? 353 TRP EEE CE2 1 ? 
ATOM   159  C CE3 . TRP A 1 24  ? 53.348 22.888 -14.946 1.000 15.648 ? 353 TRP EEE CE3 1 ? 
ATOM   160  C CZ2 . TRP A 1 24  ? 53.852 25.452 -16.026 1.000 15.491 ? 353 TRP EEE CZ2 1 ? 
ATOM   161  C CZ3 . TRP A 1 24  ? 54.205 23.770 -14.326 1.000 16.431 ? 353 TRP EEE CZ3 1 ? 
ATOM   162  C CH2 . TRP A 1 24  ? 54.441 25.039 -14.853 1.000 16.321 ? 353 TRP EEE CH2 1 ? 
ATOM   163  N N   . ASN A 1 25  ? 50.294 20.202 -13.997 1.000 15.146 ? 354 ASN EEE N   1 ? 
ATOM   164  C CA  A ASN A 1 25  ? 50.398 20.243 -12.516 0.500 15.831 ? 354 ASN EEE CA  1 ? 
ATOM   165  C CA  B ASN A 1 25  ? 50.398 20.222 -12.521 0.500 15.831 ? 354 ASN EEE CA  1 ? 
ATOM   166  C C   . ASN A 1 25  ? 51.850 20.476 -12.105 1.000 16.173 ? 354 ASN EEE C   1 ? 
ATOM   167  O O   . ASN A 1 25  ? 52.763 19.998 -12.802 1.000 16.037 ? 354 ASN EEE O   1 ? 
ATOM   168  C CB  A ASN A 1 25  ? 49.884 18.967 -11.854 0.500 16.820 ? 354 ASN EEE CB  1 ? 
ATOM   169  C CB  B ASN A 1 25  ? 49.885 18.912 -11.934 0.500 16.845 ? 354 ASN EEE CB  1 ? 
ATOM   170  C CG  A ASN A 1 25  ? 48.383 18.957 -11.674 0.500 19.854 ? 354 ASN EEE CG  1 ? 
ATOM   171  C CG  B ASN A 1 25  ? 49.736 18.987 -10.434 0.500 19.700 ? 354 ASN EEE CG  1 ? 
ATOM   172  O OD1 A ASN A 1 25  ? 47.780 19.981 -11.354 0.500 24.755 ? 354 ASN EEE OD1 1 ? 
ATOM   173  O OD1 B ASN A 1 25  ? 48.771 19.563 -9.941  0.500 23.386 ? 354 ASN EEE OD1 1 ? 
ATOM   174  N ND2 A ASN A 1 25  ? 47.776 17.801 -11.878 0.500 19.245 ? 354 ASN EEE ND2 1 ? 
ATOM   175  N ND2 B ASN A 1 25  ? 50.694 18.426 -9.715  0.500 20.698 ? 354 ASN EEE ND2 1 ? 
ATOM   176  N N   . ARG A 1 26  ? 52.032 21.184 -10.992 1.000 16.896 ? 355 ARG EEE N   1 ? 
ATOM   177  C CA  . ARG A 1 26  ? 53.356 21.341 -10.353 1.000 17.249 ? 355 ARG EEE CA  1 ? 
ATOM   178  C C   . ARG A 1 26  ? 53.243 20.943 -8.881  1.000 18.911 ? 355 ARG EEE C   1 ? 
ATOM   179  O O   . ARG A 1 26  ? 52.330 21.442 -8.192  1.000 19.887 ? 355 ARG EEE O   1 ? 
ATOM   180  C CB  . ARG A 1 26  ? 53.866 22.774 -10.462 1.000 17.586 ? 355 ARG EEE CB  1 ? 
ATOM   181  C CG  . ARG A 1 26  ? 55.107 23.020 -9.619  1.000 18.936 ? 355 ARG EEE CG  1 ? 
ATOM   182  C CD  . ARG A 1 26  ? 55.822 24.279 -10.017 1.000 20.386 ? 355 ARG EEE CD  1 ? 
ATOM   183  N NE  . ARG A 1 26  ? 56.551 24.079 -11.255 1.000 19.513 ? 355 ARG EEE NE  1 ? 
ATOM   184  C CZ  . ARG A 1 26  ? 57.415 24.937 -11.766 1.000 21.542 ? 355 ARG EEE CZ  1 ? 
ATOM   185  N NH1 . ARG A 1 26  ? 57.663 26.082 -11.147 1.000 24.550 ? 355 ARG EEE NH1 1 ? 
ATOM   186  N NH2 . ARG A 1 26  ? 58.043 24.643 -12.888 1.000 22.058 ? 355 ARG EEE NH2 1 ? 
ATOM   187  N N   . LYS A 1 27  ? 54.157 20.083 -8.440  1.000 19.145 ? 356 LYS EEE N   1 ? 
ATOM   188  C CA  . LYS A 1 27  ? 54.366 19.735 -7.017  1.000 19.612 ? 356 LYS EEE CA  1 ? 
ATOM   189  C C   . LYS A 1 27  ? 55.743 20.233 -6.594  1.000 20.146 ? 356 LYS EEE C   1 ? 
ATOM   190  O O   . LYS A 1 27  ? 56.748 19.885 -7.254  1.000 20.098 ? 356 LYS EEE O   1 ? 
ATOM   191  C CB  . LYS A 1 27  ? 54.229 18.225 -6.830  1.000 22.243 ? 356 LYS EEE CB  1 ? 
ATOM   192  C CG  . LYS A 1 27  ? 54.504 17.709 -5.424  1.000 28.919 ? 356 LYS EEE CG  1 ? 
ATOM   193  C CD  . LYS A 1 27  ? 53.366 17.898 -4.463  1.000 37.799 ? 356 LYS EEE CD  1 ? 
ATOM   194  C CE  . LYS A 1 27  ? 53.441 16.926 -3.303  1.000 45.772 ? 356 LYS EEE CE  1 ? 
ATOM   195  N NZ  . LYS A 1 27  ? 52.399 17.204 -2.289  1.000 50.582 ? 356 LYS EEE NZ  1 ? 
ATOM   196  N N   . ARG A 1 28  ? 55.790 21.004 -5.507  1.000 20.807 ? 357 ARG EEE N   1 ? 
ATOM   197  C CA  . ARG A 1 28  ? 57.066 21.424 -4.882  1.000 22.612 ? 357 ARG EEE CA  1 ? 
ATOM   198  C C   . ARG A 1 28  ? 57.482 20.326 -3.903  1.000 22.503 ? 357 ARG EEE C   1 ? 
ATOM   199  O O   . ARG A 1 28  ? 56.661 19.948 -3.039  1.000 28.498 ? 357 ARG EEE O   1 ? 
ATOM   200  C CB  . ARG A 1 28  ? 56.931 22.782 -4.185  1.000 24.638 ? 357 ARG EEE CB  1 ? 
ATOM   201  C CG  . ARG A 1 28  ? 58.221 23.275 -3.547  1.000 30.642 ? 357 ARG EEE CG  1 ? 
ATOM   202  C CD  . ARG A 1 28  ? 58.031 24.644 -2.918  1.000 40.139 ? 357 ARG EEE CD  1 ? 
ATOM   203  N NE  . ARG A 1 28  ? 58.645 24.711 -1.601  1.000 53.992 ? 357 ARG EEE NE  1 ? 
ATOM   204  C CZ  . ARG A 1 28  ? 57.997 24.651 -0.439  1.000 56.525 ? 357 ARG EEE CZ  1 ? 
ATOM   205  N NH1 . ARG A 1 28  ? 56.679 24.533 -0.393  1.000 58.167 ? 357 ARG EEE NH1 1 ? 
ATOM   206  N NH2 . ARG A 1 28  ? 58.686 24.721 0.686   1.000 66.045 ? 357 ARG EEE NH2 1 ? 
ATOM   207  N N   . ILE A 1 29  ? 58.690 19.802 -4.090  1.000 22.434 ? 358 ILE EEE N   1 ? 
ATOM   208  C CA  . ILE A 1 29  ? 59.322 18.768 -3.222  1.000 25.811 ? 358 ILE EEE CA  1 ? 
ATOM   209  C C   . ILE A 1 29  ? 60.390 19.476 -2.385  1.000 24.432 ? 358 ILE EEE C   1 ? 
ATOM   210  O O   . ILE A 1 29  ? 61.288 20.105 -2.975  1.000 24.802 ? 358 ILE EEE O   1 ? 
ATOM   211  C CB  . ILE A 1 29  ? 59.928 17.634 -4.074  1.000 29.417 ? 358 ILE EEE CB  1 ? 
ATOM   212  C CG1 . ILE A 1 29  ? 58.898 16.955 -4.984  1.000 34.266 ? 358 ILE EEE CG1 1 ? 
ATOM   213  C CG2 . ILE A 1 29  ? 60.654 16.626 -3.193  1.000 31.257 ? 358 ILE EEE CG2 1 ? 
ATOM   214  C CD1 . ILE A 1 29  ? 57.837 16.180 -4.253  1.000 36.699 ? 358 ILE EEE CD1 1 ? 
ATOM   215  N N   . SER A 1 30  ? 60.301 19.390 -1.058  1.000 26.152 ? 359 SER EEE N   1 ? 
ATOM   216  C CA  . SER A 1 30  ? 61.328 19.971 -0.157  1.000 29.110 ? 359 SER EEE CA  1 ? 
ATOM   217  C C   . SER A 1 30  ? 61.410 19.180 1.149   1.000 25.284 ? 359 SER EEE C   1 ? 
ATOM   218  O O   . SER A 1 30  ? 60.469 18.441 1.472   1.000 26.405 ? 359 SER EEE O   1 ? 
ATOM   219  C CB  . SER A 1 30  ? 61.056 21.434 0.090   1.000 37.999 ? 359 SER EEE CB  1 ? 
ATOM   220  O OG  . SER A 1 30  ? 59.779 21.614 0.680   1.000 42.461 ? 359 SER EEE OG  1 ? 
ATOM   221  N N   . ASN A 1 31  ? 62.527 19.339 1.861   1.000 31.356 ? 360 ASN EEE N   1 ? 
ATOM   222  C CA  . ASN A 1 31  ? 62.675 18.884 3.266   1.000 33.643 ? 360 ASN EEE CA  1 ? 
ATOM   223  C C   . ASN A 1 31  ? 62.421 17.377 3.306   1.000 29.121 ? 360 ASN EEE C   1 ? 
ATOM   224  O O   . ASN A 1 31  ? 61.523 16.940 4.041   1.000 33.039 ? 360 ASN EEE O   1 ? 
ATOM   225  C CB  . ASN A 1 31  ? 61.745 19.687 4.177   1.000 36.164 ? 360 ASN EEE CB  1 ? 
ATOM   226  C CG  . ASN A 1 31  ? 62.026 21.173 4.105   1.000 42.471 ? 360 ASN EEE CG  1 ? 
ATOM   227  O OD1 . ASN A 1 31  ? 63.056 21.636 4.589   1.000 48.975 ? 360 ASN EEE OD1 1 ? 
ATOM   228  N ND2 . ASN A 1 31  ? 61.130 21.926 3.489   1.000 49.667 ? 360 ASN EEE ND2 1 ? 
ATOM   229  N N   . CYS A 1 32  ? 63.167 16.621 2.498   1.000 29.596 ? 361 CYS EEE N   1 ? 
ATOM   230  C CA  . CYS A 1 32  ? 63.046 15.148 2.395   1.000 29.809 ? 361 CYS EEE CA  1 ? 
ATOM   231  C C   . CYS A 1 32  ? 64.320 14.543 1.793   1.000 26.319 ? 361 CYS EEE C   1 ? 
ATOM   232  O O   . CYS A 1 32  ? 65.140 15.293 1.220   1.000 28.671 ? 361 CYS EEE O   1 ? 
ATOM   233  C CB  . CYS A 1 32  ? 61.817 14.771 1.576   1.000 28.767 ? 361 CYS EEE CB  1 ? 
ATOM   234  S SG  . CYS A 1 32  ? 61.774 15.530 -0.071  1.000 28.228 ? 361 CYS EEE SG  1 ? 
ATOM   235  N N   . VAL A 1 33  ? 64.463 13.227 1.935   1.000 26.732 ? 362 VAL EEE N   1 ? 
ATOM   236  C CA  . VAL A 1 33  ? 65.556 12.417 1.326   1.000 30.256 ? 362 VAL EEE CA  1 ? 
ATOM   237  C C   . VAL A 1 33  ? 65.030 11.832 0.014   1.000 26.568 ? 362 VAL EEE C   1 ? 
ATOM   238  O O   . VAL A 1 33  ? 64.018 11.105 0.057   1.000 27.580 ? 362 VAL EEE O   1 ? 
ATOM   239  C CB  . VAL A 1 33  ? 66.039 11.312 2.283   1.000 33.751 ? 362 VAL EEE CB  1 ? 
ATOM   240  C CG1 . VAL A 1 33  ? 67.185 10.510 1.686   1.000 36.589 ? 362 VAL EEE CG1 1 ? 
ATOM   241  C CG2 . VAL A 1 33  ? 66.431 11.883 3.635   1.000 38.251 ? 362 VAL EEE CG2 1 ? 
ATOM   242  N N   . ALA A 1 34  ? 65.686 12.164 -1.097  1.000 29.040 ? 363 ALA EEE N   1 ? 
ATOM   243  C CA  . ALA A 1 34  ? 65.320 11.726 -2.461  1.000 29.848 ? 363 ALA EEE CA  1 ? 
ATOM   244  C C   . ALA A 1 34  ? 66.144 10.487 -2.812  1.000 31.801 ? 363 ALA EEE C   1 ? 
ATOM   245  O O   . ALA A 1 34  ? 67.380 10.593 -2.818  1.000 37.813 ? 363 ALA EEE O   1 ? 
ATOM   246  C CB  . ALA A 1 34  ? 65.572 12.838 -3.448  1.000 32.668 ? 363 ALA EEE CB  1 ? 
ATOM   247  N N   . ASP A 1 35  ? 65.494 9.356  -3.080  1.000 29.851 ? 364 ASP EEE N   1 ? 
ATOM   248  C CA  . ASP A 1 35  ? 66.181 8.178  -3.668  1.000 29.458 ? 364 ASP EEE CA  1 ? 
ATOM   249  C C   . ASP A 1 35  ? 65.917 8.190  -5.175  1.000 24.786 ? 364 ASP EEE C   1 ? 
ATOM   250  O O   . ASP A 1 35  ? 64.887 7.646  -5.605  1.000 29.539 ? 364 ASP EEE O   1 ? 
ATOM   251  C CB  . ASP A 1 35  ? 65.751 6.860  -3.027  1.000 32.418 ? 364 ASP EEE CB  1 ? 
ATOM   252  C CG  . ASP A 1 35  ? 66.611 5.695  -3.484  1.000 33.639 ? 364 ASP EEE CG  1 ? 
ATOM   253  O OD1 . ASP A 1 35  ? 67.541 5.927  -4.296  1.000 36.570 ? 364 ASP EEE OD1 1 ? 
ATOM   254  O OD2 . ASP A 1 35  ? 66.355 4.569  -3.024  1.000 44.330 ? 364 ASP EEE OD2 1 ? 
ATOM   255  N N   . TYR A 1 36  ? 66.815 8.802  -5.939  1.000 25.280 ? 365 TYR EEE N   1 ? 
ATOM   256  C CA  . TYR A 1 36  ? 66.666 8.969  -7.403  1.000 23.775 ? 365 TYR EEE CA  1 ? 
ATOM   257  C C   . TYR A 1 36  ? 66.871 7.615  -8.089  1.000 22.699 ? 365 TYR EEE C   1 ? 
ATOM   258  O O   . TYR A 1 36  ? 66.387 7.482  -9.204  1.000 19.645 ? 365 TYR EEE O   1 ? 
ATOM   259  C CB  . TYR A 1 36  ? 67.617 10.037 -7.938  1.000 25.609 ? 365 TYR EEE CB  1 ? 
ATOM   260  C CG  . TYR A 1 36  ? 67.335 11.411 -7.391  1.000 28.166 ? 365 TYR EEE CG  1 ? 
ATOM   261  C CD1 . TYR A 1 36  ? 66.207 12.114 -7.779  1.000 27.759 ? 365 TYR EEE CD1 1 ? 
ATOM   262  C CD2 . TYR A 1 36  ? 68.175 11.993 -6.454  1.000 30.411 ? 365 TYR EEE CD2 1 ? 
ATOM   263  C CE1 . TYR A 1 36  ? 65.932 13.374 -7.273  1.000 31.035 ? 365 TYR EEE CE1 1 ? 
ATOM   264  C CE2 . TYR A 1 36  ? 67.916 13.252 -5.939  1.000 32.543 ? 365 TYR EEE CE2 1 ? 
ATOM   265  C CZ  . TYR A 1 36  ? 66.789 13.943 -6.348  1.000 33.933 ? 365 TYR EEE CZ  1 ? 
ATOM   266  O OH  . TYR A 1 36  ? 66.522 15.187 -5.852  1.000 39.634 ? 365 TYR EEE OH  1 ? 
ATOM   267  N N   . SER A 1 37  ? 67.511 6.646  -7.425  1.000 23.559 ? 366 SER EEE N   1 ? 
ATOM   268  C CA  . SER A 1 37  ? 67.752 5.286  -7.977  1.000 24.108 ? 366 SER EEE CA  1 ? 
ATOM   269  C C   . SER A 1 37  ? 66.416 4.605  -8.294  1.000 22.113 ? 366 SER EEE C   1 ? 
ATOM   270  O O   . SER A 1 37  ? 66.367 3.841  -9.266  1.000 25.017 ? 366 SER EEE O   1 ? 
ATOM   271  C CB  . SER A 1 37  ? 68.601 4.437  -7.049  1.000 25.258 ? 366 SER EEE CB  1 ? 
ATOM   272  O OG  . SER A 1 37  ? 67.834 3.957  -5.956  1.000 27.065 ? 366 SER EEE OG  1 ? 
ATOM   273  N N   . VAL A 1 38  ? 65.359 4.890  -7.533  1.000 22.622 ? 367 VAL EEE N   1 ? 
ATOM   274  C CA  . VAL A 1 38  ? 63.999 4.322  -7.775  1.000 24.260 ? 367 VAL EEE CA  1 ? 
ATOM   275  C C   . VAL A 1 38  ? 63.564 4.722  -9.190  1.000 22.843 ? 367 VAL EEE C   1 ? 
ATOM   276  O O   . VAL A 1 38  ? 62.878 3.921  -9.852  1.000 25.605 ? 367 VAL EEE O   1 ? 
ATOM   277  C CB  . VAL A 1 38  ? 62.999 4.795  -6.702  1.000 27.151 ? 367 VAL EEE CB  1 ? 
ATOM   278  C CG1 . VAL A 1 38  ? 61.561 4.458  -7.054  1.000 32.225 ? 367 VAL EEE CG1 1 ? 
ATOM   279  C CG2 . VAL A 1 38  ? 63.361 4.232  -5.336  1.000 31.565 ? 367 VAL EEE CG2 1 ? 
ATOM   280  N N   . LEU A 1 39  ? 63.974 5.908  -9.641  1.000 19.584 ? 368 LEU EEE N   1 ? 
ATOM   281  C CA  . LEU A 1 39  ? 63.637 6.436  -10.987 1.000 18.559 ? 368 LEU EEE CA  1 ? 
ATOM   282  C C   . LEU A 1 39  ? 64.637 5.921  -12.028 1.000 18.476 ? 368 LEU EEE C   1 ? 
ATOM   283  O O   . LEU A 1 39  ? 64.178 5.337  -13.032 1.000 20.666 ? 368 LEU EEE O   1 ? 
ATOM   284  C CB  . LEU A 1 39  ? 63.618 7.967  -10.943 1.000 19.893 ? 368 LEU EEE CB  1 ? 
ATOM   285  C CG  . LEU A 1 39  ? 62.641 8.582  -9.947  1.000 21.223 ? 368 LEU EEE CG  1 ? 
ATOM   286  C CD1 . LEU A 1 39  ? 62.744 10.097 -9.979  1.000 21.035 ? 368 LEU EEE CD1 1 ? 
ATOM   287  C CD2 . LEU A 1 39  ? 61.215 8.141  -10.223 1.000 22.850 ? 368 LEU EEE CD2 1 ? 
ATOM   288  N N   . TYR A 1 40  ? 65.943 6.154  -11.851 1.000 19.289 ? 369 TYR EEE N   1 ? 
ATOM   289  C CA  . TYR A 1 40  ? 66.934 5.913  -12.936 1.000 20.958 ? 369 TYR EEE CA  1 ? 
ATOM   290  C C   . TYR A 1 40  ? 67.153 4.410  -13.143 1.000 22.102 ? 369 TYR EEE C   1 ? 
ATOM   291  O O   . TYR A 1 40  ? 67.609 4.034  -14.239 1.000 25.972 ? 369 TYR EEE O   1 ? 
ATOM   292  C CB  . TYR A 1 40  ? 68.228 6.719  -12.775 1.000 22.346 ? 369 TYR EEE CB  1 ? 
ATOM   293  C CG  . TYR A 1 40  ? 69.110 6.460  -11.580 1.000 25.234 ? 369 TYR EEE CG  1 ? 
ATOM   294  C CD1 . TYR A 1 40  ? 69.804 5.270  -11.420 1.000 27.618 ? 369 TYR EEE CD1 1 ? 
ATOM   295  C CD2 . TYR A 1 40  ? 69.346 7.466  -10.658 1.000 25.447 ? 369 TYR EEE CD2 1 ? 
ATOM   296  C CE1 . TYR A 1 40  ? 70.645 5.064  -10.336 1.000 31.284 ? 369 TYR EEE CE1 1 ? 
ATOM   297  C CE2 . TYR A 1 40  ? 70.180 7.279  -9.571  1.000 28.992 ? 369 TYR EEE CE2 1 ? 
ATOM   298  C CZ  . TYR A 1 40  ? 70.839 6.074  -9.411  1.000 32.517 ? 369 TYR EEE CZ  1 ? 
ATOM   299  O OH  . TYR A 1 40  ? 71.657 5.900  -8.331  1.000 40.920 ? 369 TYR EEE OH  1 ? 
ATOM   300  N N   . ASN A 1 41  ? 66.792 3.565  -12.179 1.000 21.484 ? 370 ASN EEE N   1 ? 
ATOM   301  C CA  . ASN A 1 41  ? 66.919 2.089  -12.336 1.000 22.417 ? 370 ASN EEE CA  1 ? 
ATOM   302  C C   . ASN A 1 41  ? 65.621 1.479  -12.865 1.000 27.219 ? 370 ASN EEE C   1 ? 
ATOM   303  O O   . ASN A 1 41  ? 65.633 0.269  -13.149 1.000 30.411 ? 370 ASN EEE O   1 ? 
ATOM   304  C CB  . ASN A 1 41  ? 67.320 1.396  -11.037 1.000 21.458 ? 370 ASN EEE CB  1 ? 
ATOM   305  C CG  . ASN A 1 41  ? 68.787 1.573  -10.732 1.000 20.731 ? 370 ASN EEE CG  1 ? 
ATOM   306  O OD1 . ASN A 1 41  ? 69.583 1.805  -11.639 1.000 21.429 ? 370 ASN EEE OD1 1 ? 
ATOM   307  N ND2 . ASN A 1 41  ? 69.138 1.484  -9.459  1.000 25.428 ? 370 ASN EEE ND2 1 ? 
ATOM   308  N N   . SER A 1 42  ? 64.554 2.265  -13.023 1.000 21.804 ? 371 SER EEE N   1 ? 
ATOM   309  C CA  . SER A 1 42  ? 63.232 1.746  -13.449 1.000 22.633 ? 371 SER EEE CA  1 ? 
ATOM   310  C C   . SER A 1 42  ? 63.277 1.383  -14.932 1.000 23.514 ? 371 SER EEE C   1 ? 
ATOM   311  O O   . SER A 1 42  ? 63.767 2.200  -15.723 1.000 26.599 ? 371 SER EEE O   1 ? 
ATOM   312  C CB  . SER A 1 42  ? 62.133 2.729  -13.190 1.000 24.389 ? 371 SER EEE CB  1 ? 
ATOM   313  O OG  . SER A 1 42  ? 60.915 2.254  -13.744 1.000 26.437 ? 371 SER EEE OG  1 ? 
ATOM   314  N N   . ALA A 1 43  ? 62.699 0.238  -15.294 1.000 22.437 ? 372 ALA EEE N   1 ? 
ATOM   315  C CA  . ALA A 1 43  ? 62.534 -0.206 -16.694 1.000 22.733 ? 372 ALA EEE CA  1 ? 
ATOM   316  C C   . ALA A 1 43  ? 61.213 0.330  -17.263 1.000 23.711 ? 372 ALA EEE C   1 ? 
ATOM   317  O O   . ALA A 1 43  ? 60.903 0.011  -18.424 1.000 24.770 ? 372 ALA EEE O   1 ? 
ATOM   318  C CB  . ALA A 1 43  ? 62.600 -1.716 -16.768 1.000 25.145 ? 372 ALA EEE CB  1 ? 
ATOM   319  N N   . SER A 1 44  ? 60.475 1.133  -16.494 1.000 21.682 ? 373 SER EEE N   1 ? 
ATOM   320  C CA  . SER A 1 44  ? 59.115 1.609  -16.862 1.000 25.006 ? 373 SER EEE CA  1 ? 
ATOM   321  C C   . SER A 1 44  ? 59.198 2.771  -17.860 1.000 24.725 ? 373 SER EEE C   1 ? 
ATOM   322  O O   . SER A 1 44  ? 58.192 2.999  -18.551 1.000 26.815 ? 373 SER EEE O   1 ? 
ATOM   323  C CB  . SER A 1 44  ? 58.321 2.018  -15.652 1.000 26.185 ? 373 SER EEE CB  1 ? 
ATOM   324  O OG  . SER A 1 44  ? 58.129 0.930  -14.765 1.000 33.444 ? 373 SER EEE OG  1 ? 
ATOM   325  N N   . PHE A 1 45  ? 60.320 3.499  -17.912 1.000 19.525 ? 374 PHE EEE N   1 ? 
ATOM   326  C CA  . PHE A 1 45  ? 60.408 4.815  -18.599 1.000 21.290 ? 374 PHE EEE CA  1 ? 
ATOM   327  C C   . PHE A 1 45  ? 60.982 4.638  -20.009 1.000 25.159 ? 374 PHE EEE C   1 ? 
ATOM   328  O O   . PHE A 1 45  ? 62.031 3.984  -20.172 1.000 30.724 ? 374 PHE EEE O   1 ? 
ATOM   329  C CB  . PHE A 1 45  ? 61.204 5.810  -17.755 1.000 19.450 ? 374 PHE EEE CB  1 ? 
ATOM   330  C CG  . PHE A 1 45  ? 60.677 6.002  -16.354 1.000 18.141 ? 374 PHE EEE CG  1 ? 
ATOM   331  C CD1 . PHE A 1 45  ? 59.347 6.324  -16.126 1.000 19.893 ? 374 PHE EEE CD1 1 ? 
ATOM   332  C CD2 . PHE A 1 45  ? 61.516 5.884  -15.257 1.000 19.268 ? 374 PHE EEE CD2 1 ? 
ATOM   333  C CE1 . PHE A 1 45  ? 58.867 6.505  -14.836 1.000 19.977 ? 374 PHE EEE CE1 1 ? 
ATOM   334  C CE2 . PHE A 1 45  ? 61.034 6.071  -13.969 1.000 19.842 ? 374 PHE EEE CE2 1 ? 
ATOM   335  C CZ  . PHE A 1 45  ? 59.714 6.375  -13.759 1.000 20.360 ? 374 PHE EEE CZ  1 ? 
ATOM   336  N N   . SER A 1 46  ? 60.295 5.210  -20.997 1.000 21.550 ? 375 SER EEE N   1 ? 
ATOM   337  C CA  . SER A 1 46  ? 60.705 5.220  -22.425 1.000 22.765 ? 375 SER EEE CA  1 ? 
ATOM   338  C C   . SER A 1 46  ? 61.609 6.427  -22.700 1.000 23.049 ? 375 SER EEE C   1 ? 
ATOM   339  O O   . SER A 1 46  ? 62.400 6.368  -23.648 1.000 24.563 ? 375 SER EEE O   1 ? 
ATOM   340  C CB  . SER A 1 46  ? 59.496 5.206  -23.324 1.000 25.002 ? 375 SER EEE CB  1 ? 
ATOM   341  O OG  . SER A 1 46  ? 58.522 6.126  -22.890 1.000 28.873 ? 375 SER EEE OG  1 ? 
ATOM   342  N N   . THR A 1 47  ? 61.467 7.506  -21.923 1.000 19.481 ? 376 THR EEE N   1 ? 
ATOM   343  C CA  . THR A 1 47  ? 62.319 8.719  -21.985 1.000 19.599 ? 376 THR EEE CA  1 ? 
ATOM   344  C C   . THR A 1 47  ? 62.844 9.005  -20.584 1.000 19.515 ? 376 THR EEE C   1 ? 
ATOM   345  O O   . THR A 1 47  ? 62.050 8.967  -19.634 1.000 17.370 ? 376 THR EEE O   1 ? 
ATOM   346  C CB  . THR A 1 47  ? 61.553 9.946  -22.497 1.000 21.805 ? 376 THR EEE CB  1 ? 
ATOM   347  O OG1 . THR A 1 47  ? 61.116 9.684  -23.828 1.000 20.771 ? 376 THR EEE OG1 1 ? 
ATOM   348  C CG2 . THR A 1 47  ? 62.378 11.215 -22.492 1.000 22.993 ? 376 THR EEE CG2 1 ? 
ATOM   349  N N   . PHE A 1 48  ? 64.141 9.260  -20.470 1.000 17.159 ? 377 PHE EEE N   1 ? 
ATOM   350  C CA  . PHE A 1 48  ? 64.786 9.707  -19.219 1.000 19.811 ? 377 PHE EEE CA  1 ? 
ATOM   351  C C   . PHE A 1 48  ? 65.979 10.553 -19.638 1.000 21.767 ? 377 PHE EEE C   1 ? 
ATOM   352  O O   . PHE A 1 48  ? 67.061 9.978  -19.833 1.000 22.646 ? 377 PHE EEE O   1 ? 
ATOM   353  C CB  . PHE A 1 48  ? 65.162 8.511  -18.342 1.000 19.876 ? 377 PHE EEE CB  1 ? 
ATOM   354  C CG  . PHE A 1 48  ? 65.303 8.845  -16.882 1.000 21.023 ? 377 PHE EEE CG  1 ? 
ATOM   355  C CD1 . PHE A 1 48  ? 66.146 9.863  -16.464 1.000 23.983 ? 377 PHE EEE CD1 1 ? 
ATOM   356  C CD2 . PHE A 1 48  ? 64.566 8.167  -15.925 1.000 22.364 ? 377 PHE EEE CD2 1 ? 
ATOM   357  C CE1 . PHE A 1 48  ? 66.264 10.177 -15.120 1.000 23.535 ? 377 PHE EEE CE1 1 ? 
ATOM   358  C CE2 . PHE A 1 48  ? 64.689 8.479  -14.581 1.000 24.308 ? 377 PHE EEE CE2 1 ? 
ATOM   359  C CZ  . PHE A 1 48  ? 65.546 9.477  -14.180 1.000 23.966 ? 377 PHE EEE CZ  1 ? 
ATOM   360  N N   . LYS A 1 49  ? 65.739 11.850 -19.854 1.000 19.570 ? 378 LYS EEE N   1 ? 
ATOM   361  C CA  . LYS A 1 49  ? 66.730 12.792 -20.431 1.000 20.228 ? 378 LYS EEE CA  1 ? 
ATOM   362  C C   . LYS A 1 49  ? 67.006 13.879 -19.399 1.000 20.922 ? 378 LYS EEE C   1 ? 
ATOM   363  O O   . LYS A 1 49  ? 66.063 14.572 -18.987 1.000 19.871 ? 378 LYS EEE O   1 ? 
ATOM   364  C CB  . LYS A 1 49  ? 66.224 13.341 -21.765 1.000 23.799 ? 378 LYS EEE CB  1 ? 
ATOM   365  C CG  . LYS A 1 49  ? 66.180 12.293 -22.868 1.000 27.731 ? 378 LYS EEE CG  1 ? 
ATOM   366  C CD  . LYS A 1 49  ? 65.762 12.794 -24.226 1.000 35.013 ? 378 LYS EEE CD  1 ? 
ATOM   367  C CE  . LYS A 1 49  ? 65.705 11.666 -25.234 1.000 38.260 ? 378 LYS EEE CE  1 ? 
ATOM   368  N NZ  . LYS A 1 49  ? 65.262 12.142 -26.564 1.000 46.769 ? 378 LYS EEE NZ  1 ? 
ATOM   369  N N   . CYS A 1 50  ? 68.264 13.999 -18.979 1.000 21.170 ? 379 CYS EEE N   1 ? 
ATOM   370  C CA  . CYS A 1 50  ? 68.697 15.011 -17.989 1.000 20.283 ? 379 CYS EEE CA  1 ? 
ATOM   371  C C   . CYS A 1 50  ? 69.541 16.070 -18.700 1.000 21.603 ? 379 CYS EEE C   1 ? 
ATOM   372  O O   . CYS A 1 50  ? 70.166 15.775 -19.745 1.000 23.597 ? 379 CYS EEE O   1 ? 
ATOM   373  C CB  . CYS A 1 50  ? 69.400 14.361 -16.803 1.000 23.249 ? 379 CYS EEE CB  1 ? 
ATOM   374  S SG  . CYS A 1 50  ? 68.316 13.242 -15.870 1.000 30.132 ? 379 CYS EEE SG  1 ? 
ATOM   375  N N   . TYR A 1 51  ? 69.452 17.291 -18.189 1.000 22.262 ? 380 TYR EEE N   1 ? 
ATOM   376  C CA  . TYR A 1 51  ? 70.119 18.501 -18.715 1.000 23.368 ? 380 TYR EEE CA  1 ? 
ATOM   377  C C   . TYR A 1 51  ? 70.812 19.178 -17.536 1.000 25.305 ? 380 TYR EEE C   1 ? 
ATOM   378  O O   . TYR A 1 51  ? 70.146 19.396 -16.502 1.000 23.210 ? 380 TYR EEE O   1 ? 
ATOM   379  C CB  . TYR A 1 51  ? 69.092 19.406 -19.394 1.000 21.635 ? 380 TYR EEE CB  1 ? 
ATOM   380  C CG  . TYR A 1 51  ? 68.327 18.728 -20.502 1.000 18.522 ? 380 TYR EEE CG  1 ? 
ATOM   381  C CD1 . TYR A 1 51  ? 67.183 17.993 -20.233 1.000 19.672 ? 380 TYR EEE CD1 1 ? 
ATOM   382  C CD2 . TYR A 1 51  ? 68.756 18.794 -21.816 1.000 19.811 ? 380 TYR EEE CD2 1 ? 
ATOM   383  C CE1 . TYR A 1 51  ? 66.476 17.361 -21.242 1.000 19.058 ? 380 TYR EEE CE1 1 ? 
ATOM   384  C CE2 . TYR A 1 51  ? 68.063 18.165 -22.837 1.000 19.063 ? 380 TYR EEE CE2 1 ? 
ATOM   385  C CZ  . TYR A 1 51  ? 66.909 17.457 -22.553 1.000 18.867 ? 380 TYR EEE CZ  1 ? 
ATOM   386  O OH  . TYR A 1 51  ? 66.217 16.830 -23.554 1.000 20.447 ? 380 TYR EEE OH  1 ? 
ATOM   387  N N   . GLY A 1 52  ? 72.117 19.410 -17.672 1.000 27.802 ? 381 GLY EEE N   1 ? 
ATOM   388  C CA  . GLY A 1 52  ? 72.953 20.082 -16.660 1.000 30.053 ? 381 GLY EEE CA  1 ? 
ATOM   389  C C   . GLY A 1 52  ? 73.154 19.242 -15.412 1.000 32.360 ? 381 GLY EEE C   1 ? 
ATOM   390  O O   . GLY A 1 52  ? 73.621 19.801 -14.403 1.000 33.190 ? 381 GLY EEE O   1 ? 
ATOM   391  N N   . VAL A 1 53  ? 72.822 17.950 -15.455 1.000 29.766 ? 382 VAL EEE N   1 ? 
ATOM   392  C CA  . VAL A 1 53  ? 73.017 17.020 -14.304 1.000 33.253 ? 382 VAL EEE CA  1 ? 
ATOM   393  C C   . VAL A 1 53  ? 73.027 15.583 -14.827 1.000 32.379 ? 382 VAL EEE C   1 ? 
ATOM   394  O O   . VAL A 1 53  ? 72.394 15.319 -15.863 1.000 30.699 ? 382 VAL EEE O   1 ? 
ATOM   395  C CB  . VAL A 1 53  ? 71.949 17.227 -13.210 1.000 36.734 ? 382 VAL EEE CB  1 ? 
ATOM   396  C CG1 . VAL A 1 53  ? 70.560 16.797 -13.661 1.000 37.090 ? 382 VAL EEE CG1 1 ? 
ATOM   397  C CG2 . VAL A 1 53  ? 72.334 16.528 -11.917 1.000 44.933 ? 382 VAL EEE CG2 1 ? 
ATOM   398  N N   . SER A 1 54  ? 73.743 14.701 -14.132 1.000 27.612 ? 383 SER EEE N   1 ? 
ATOM   399  C CA  . SER A 1 54  ? 73.858 13.259 -14.464 1.000 31.189 ? 383 SER EEE CA  1 ? 
ATOM   400  C C   . SER A 1 54  ? 72.913 12.473 -13.563 1.000 26.871 ? 383 SER EEE C   1 ? 
ATOM   401  O O   . SER A 1 54  ? 72.976 12.609 -12.345 1.000 30.265 ? 383 SER EEE O   1 ? 
ATOM   402  C CB  . SER A 1 54  ? 75.274 12.789 -14.316 1.000 33.693 ? 383 SER EEE CB  1 ? 
ATOM   403  O OG  . SER A 1 54  ? 75.347 11.391 -14.529 1.000 36.745 ? 383 SER EEE OG  1 ? 
ATOM   404  N N   . PRO A 1 55  ? 72.009 11.635 -14.121 1.000 32.241 ? 384 PRO EEE N   1 ? 
ATOM   405  C CA  . PRO A 1 55  ? 71.011 10.947 -13.301 1.000 31.774 ? 384 PRO EEE CA  1 ? 
ATOM   406  C C   . PRO A 1 55  ? 71.647 10.155 -12.144 1.000 31.884 ? 384 PRO EEE C   1 ? 
ATOM   407  O O   . PRO A 1 55  ? 71.147 10.253 -11.033 1.000 28.764 ? 384 PRO EEE O   1 ? 
ATOM   408  C CB  . PRO A 1 55  ? 70.232 10.039 -14.272 1.000 36.479 ? 384 PRO EEE CB  1 ? 
ATOM   409  C CG  . PRO A 1 55  ? 70.896 10.189 -15.636 1.000 36.287 ? 384 PRO EEE CG  1 ? 
ATOM   410  C CD  . PRO A 1 55  ? 71.892 11.326 -15.553 1.000 34.762 ? 384 PRO EEE CD  1 ? 
ATOM   411  N N   . THR A 1 56  ? 72.748 9.438  -12.394 1.000 34.151 ? 385 THR EEE N   1 ? 
ATOM   412  C CA  . THR A 1 56  ? 73.413 8.576  -11.375 1.000 37.439 ? 385 THR EEE CA  1 ? 
ATOM   413  C C   . THR A 1 56  ? 74.076 9.441  -10.294 1.000 43.568 ? 385 THR EEE C   1 ? 
ATOM   414  O O   . THR A 1 56  ? 74.223 8.943  -9.161  1.000 54.564 ? 385 THR EEE O   1 ? 
ATOM   415  C CB  . THR A 1 56  ? 74.395 7.601  -12.031 1.000 38.597 ? 385 THR EEE CB  1 ? 
ATOM   416  O OG1 . THR A 1 56  ? 75.306 8.355  -12.828 1.000 37.019 ? 385 THR EEE OG1 1 ? 
ATOM   417  C CG2 . THR A 1 56  ? 73.690 6.580  -12.894 1.000 36.228 ? 385 THR EEE CG2 1 ? 
ATOM   418  N N   . LYS A 1 57  ? 74.426 10.690 -10.615 1.000 35.738 ? 386 LYS EEE N   1 ? 
ATOM   419  C CA  . LYS A 1 57  ? 75.120 11.619 -9.683  1.000 40.749 ? 386 LYS EEE CA  1 ? 
ATOM   420  C C   . LYS A 1 57  ? 74.093 12.316 -8.783  1.000 36.463 ? 386 LYS EEE C   1 ? 
ATOM   421  O O   . LYS A 1 57  ? 74.517 12.927 -7.796  1.000 36.167 ? 386 LYS EEE O   1 ? 
ATOM   422  C CB  . LYS A 1 57  ? 75.966 12.632 -10.461 1.000 46.972 ? 386 LYS EEE CB  1 ? 
ATOM   423  C CG  . LYS A 1 57  ? 77.465 12.356 -10.435 1.000 60.023 ? 386 LYS EEE CG  1 ? 
ATOM   424  C CD  . LYS A 1 57  ? 78.223 12.906 -11.628 1.000 69.142 ? 386 LYS EEE CD  1 ? 
ATOM   425  C CE  . LYS A 1 57  ? 79.437 12.072 -11.986 1.000 74.828 ? 386 LYS EEE CE  1 ? 
ATOM   426  N NZ  . LYS A 1 57  ? 80.450 12.862 -12.726 1.000 75.208 ? 386 LYS EEE NZ  1 ? 
ATOM   427  N N   . LEU A 1 58  ? 72.798 12.223 -9.102  1.000 34.755 ? 387 LEU EEE N   1 ? 
ATOM   428  C CA  . LEU A 1 58  ? 71.724 12.948 -8.366  1.000 34.445 ? 387 LEU EEE CA  1 ? 
ATOM   429  C C   . LEU A 1 58  ? 71.726 12.564 -6.881  1.000 33.116 ? 387 LEU EEE C   1 ? 
ATOM   430  O O   . LEU A 1 58  ? 71.500 13.465 -6.054  1.000 32.741 ? 387 LEU EEE O   1 ? 
ATOM   431  C CB  . LEU A 1 58  ? 70.364 12.649 -9.001  1.000 32.207 ? 387 LEU EEE CB  1 ? 
ATOM   432  C CG  . LEU A 1 58  ? 70.024 13.484 -10.233 1.000 32.913 ? 387 LEU EEE CG  1 ? 
ATOM   433  C CD1 . LEU A 1 58  ? 68.664 13.089 -10.775 1.000 32.202 ? 387 LEU EEE CD1 1 ? 
ATOM   434  C CD2 . LEU A 1 58  ? 70.048 14.969 -9.907  1.000 34.687 ? 387 LEU EEE CD2 1 ? 
ATOM   435  N N   . ASN A 1 59  ? 71.969 11.290 -6.553  1.000 32.641 ? 388 ASN EEE N   1 ? 
ATOM   436  C CA  . ASN A 1 59  ? 71.980 10.797 -5.147  1.000 33.956 ? 388 ASN EEE CA  1 ? 
ATOM   437  C C   . ASN A 1 59  ? 73.153 11.441 -4.385  1.000 36.483 ? 388 ASN EEE C   1 ? 
ATOM   438  O O   . ASN A 1 59  ? 73.162 11.329 -3.146  1.000 34.044 ? 388 ASN EEE O   1 ? 
ATOM   439  C CB  . ASN A 1 59  ? 71.997 9.263  -5.074  1.000 38.689 ? 388 ASN EEE CB  1 ? 
ATOM   440  C CG  . ASN A 1 59  ? 70.617 8.633  -5.080  1.000 41.613 ? 388 ASN EEE CG  1 ? 
ATOM   441  O OD1 . ASN A 1 59  ? 69.604 9.327  -5.131  1.000 42.691 ? 388 ASN EEE OD1 1 ? 
ATOM   442  N ND2 . ASN A 1 59  ? 70.559 7.312  -5.009  1.000 42.145 ? 388 ASN EEE ND2 1 ? 
ATOM   443  N N   . ASP A 1 60  ? 74.096 12.086 -5.089  1.000 35.309 ? 389 ASP EEE N   1 ? 
ATOM   444  C CA  . ASP A 1 60  ? 75.281 12.767 -4.497  1.000 40.014 ? 389 ASP EEE CA  1 ? 
ATOM   445  C C   . ASP A 1 60  ? 75.034 14.272 -4.342  1.000 40.579 ? 389 ASP EEE C   1 ? 
ATOM   446  O O   . ASP A 1 60  ? 75.914 14.932 -3.768  1.000 41.723 ? 389 ASP EEE O   1 ? 
ATOM   447  C CB  . ASP A 1 60  ? 76.536 12.586 -5.355  1.000 42.021 ? 389 ASP EEE CB  1 ? 
ATOM   448  C CG  . ASP A 1 60  ? 76.975 11.143 -5.519  1.000 46.589 ? 389 ASP EEE CG  1 ? 
ATOM   449  O OD1 . ASP A 1 60  ? 76.676 10.334 -4.619  1.000 50.211 ? 389 ASP EEE OD1 1 ? 
ATOM   450  O OD2 . ASP A 1 60  ? 77.610 10.839 -6.551  1.000 57.545 ? 389 ASP EEE OD2 1 ? 
ATOM   451  N N   . LEU A 1 61  ? 73.913 14.802 -4.845  1.000 37.340 ? 390 LEU EEE N   1 ? 
ATOM   452  C CA  . LEU A 1 61  ? 73.657 16.269 -4.897  1.000 35.854 ? 390 LEU EEE CA  1 ? 
ATOM   453  C C   . LEU A 1 61  ? 72.568 16.662 -3.894  1.000 33.265 ? 390 LEU EEE C   1 ? 
ATOM   454  O O   . LEU A 1 61  ? 71.725 15.803 -3.535  1.000 30.595 ? 390 LEU EEE O   1 ? 
ATOM   455  C CB  . LEU A 1 61  ? 73.262 16.675 -6.320  1.000 38.620 ? 390 LEU EEE CB  1 ? 
ATOM   456  C CG  . LEU A 1 61  ? 74.364 16.547 -7.371  1.000 43.391 ? 390 LEU EEE CG  1 ? 
ATOM   457  C CD1 . LEU A 1 61  ? 73.841 16.933 -8.744  1.000 42.183 ? 390 LEU EEE CD1 1 ? 
ATOM   458  C CD2 . LEU A 1 61  ? 75.573 17.398 -7.010  1.000 45.719 ? 390 LEU EEE CD2 1 ? 
ATOM   459  N N   . CYS A 1 62  ? 72.613 17.923 -3.452  1.000 36.150 ? 391 CYS EEE N   1 ? 
ATOM   460  C CA  . CYS A 1 62  ? 71.629 18.558 -2.539  1.000 33.307 ? 391 CYS EEE CA  1 ? 
ATOM   461  C C   . CYS A 1 62  ? 71.051 19.803 -3.220  1.000 33.853 ? 391 CYS EEE C   1 ? 
ATOM   462  O O   . CYS A 1 62  ? 71.817 20.554 -3.868  1.000 31.788 ? 391 CYS EEE O   1 ? 
ATOM   463  C CB  . CYS A 1 62  ? 72.259 18.927 -1.201  1.000 39.712 ? 391 CYS EEE CB  1 ? 
ATOM   464  S SG  . CYS A 1 62  ? 72.544 17.501 -0.121  1.000 45.689 ? 391 CYS EEE SG  1 ? 
ATOM   465  N N   . PHE A 1 63  ? 69.738 19.992 -3.100  1.000 30.828 ? 392 PHE EEE N   1 ? 
ATOM   466  C CA  . PHE A 1 63  ? 68.996 21.119 -3.714  1.000 28.939 ? 392 PHE EEE CA  1 ? 
ATOM   467  C C   . PHE A 1 63  ? 68.113 21.765 -2.649  1.000 24.452 ? 392 PHE EEE C   1 ? 
ATOM   468  O O   . PHE A 1 63  ? 67.744 21.098 -1.663  1.000 28.785 ? 392 PHE EEE O   1 ? 
ATOM   469  C CB  . PHE A 1 63  ? 68.224 20.622 -4.942  1.000 28.394 ? 392 PHE EEE CB  1 ? 
ATOM   470  C CG  . PHE A 1 63  ? 69.141 20.242 -6.074  1.000 26.848 ? 392 PHE EEE CG  1 ? 
ATOM   471  C CD1 . PHE A 1 63  ? 69.767 21.217 -6.834  1.000 28.529 ? 392 PHE EEE CD1 1 ? 
ATOM   472  C CD2 . PHE A 1 63  ? 69.418 18.912 -6.350  1.000 30.871 ? 392 PHE EEE CD2 1 ? 
ATOM   473  C CE1 . PHE A 1 63  ? 70.633 20.872 -7.860  1.000 29.819 ? 392 PHE EEE CE1 1 ? 
ATOM   474  C CE2 . PHE A 1 63  ? 70.289 18.568 -7.372  1.000 27.749 ? 392 PHE EEE CE2 1 ? 
ATOM   475  C CZ  . PHE A 1 63  ? 70.888 19.547 -8.131  1.000 29.725 ? 392 PHE EEE CZ  1 ? 
ATOM   476  N N   . THR A 1 64  ? 67.776 23.036 -2.870  1.000 27.811 ? 393 THR EEE N   1 ? 
ATOM   477  C CA  . THR A 1 64  ? 66.864 23.838 -2.016  1.000 30.611 ? 393 THR EEE CA  1 ? 
ATOM   478  C C   . THR A 1 64  ? 65.439 23.311 -2.195  1.000 28.971 ? 393 THR EEE C   1 ? 
ATOM   479  O O   . THR A 1 64  ? 64.743 23.067 -1.189  1.000 30.455 ? 393 THR EEE O   1 ? 
ATOM   480  C CB  . THR A 1 64  ? 66.944 25.321 -2.397  1.000 34.412 ? 393 THR EEE CB  1 ? 
ATOM   481  O OG1 . THR A 1 64  ? 68.297 25.620 -2.746  1.000 39.448 ? 393 THR EEE OG1 1 ? 
ATOM   482  C CG2 . THR A 1 64  ? 66.461 26.228 -1.288  1.000 37.595 ? 393 THR EEE CG2 1 ? 
ATOM   483  N N   . ASN A 1 65  ? 65.048 23.119 -3.455  1.000 27.843 ? 394 ASN EEE N   1 ? 
ATOM   484  C CA  . ASN A 1 65  ? 63.700 22.646 -3.852  1.000 27.764 ? 394 ASN EEE CA  1 ? 
ATOM   485  C C   . ASN A 1 65  ? 63.828 21.782 -5.106  1.000 24.528 ? 394 ASN EEE C   1 ? 
ATOM   486  O O   . ASN A 1 65  ? 64.741 22.017 -5.904  1.000 23.229 ? 394 ASN EEE O   1 ? 
ATOM   487  C CB  . ASN A 1 65  ? 62.751 23.812 -4.135  1.000 30.602 ? 394 ASN EEE CB  1 ? 
ATOM   488  C CG  . ASN A 1 65  ? 62.427 24.634 -2.906  1.000 33.736 ? 394 ASN EEE CG  1 ? 
ATOM   489  O OD1 . ASN A 1 65  ? 61.802 24.141 -1.970  1.000 40.467 ? 394 ASN EEE OD1 1 ? 
ATOM   490  N ND2 . ASN A 1 65  ? 62.835 25.892 -2.914  1.000 36.582 ? 394 ASN EEE ND2 1 ? 
ATOM   491  N N   . VAL A 1 66  ? 62.931 20.815 -5.250  1.000 22.522 ? 395 VAL EEE N   1 ? 
ATOM   492  C CA  . VAL A 1 66  ? 62.707 20.116 -6.543  1.000 21.663 ? 395 VAL EEE CA  1 ? 
ATOM   493  C C   . VAL A 1 66  ? 61.252 20.377 -6.934  1.000 19.861 ? 395 VAL EEE C   1 ? 
ATOM   494  O O   . VAL A 1 66  ? 60.376 20.283 -6.070  1.000 23.295 ? 395 VAL EEE O   1 ? 
ATOM   495  C CB  . VAL A 1 66  ? 63.043 18.619 -6.440  1.000 21.112 ? 395 VAL EEE CB  1 ? 
ATOM   496  C CG1 . VAL A 1 66  ? 62.777 17.892 -7.751  1.000 22.453 ? 395 VAL EEE CG1 1 ? 
ATOM   497  C CG2 . VAL A 1 66  ? 64.478 18.408 -5.985  1.000 23.179 ? 395 VAL EEE CG2 1 ? 
ATOM   498  N N   . TYR A 1 67  ? 61.022 20.756 -8.186  1.000 18.911 ? 396 TYR EEE N   1 ? 
ATOM   499  C CA  . TYR A 1 67  ? 59.663 20.922 -8.750  1.000 19.744 ? 396 TYR EEE CA  1 ? 
ATOM   500  C C   . TYR A 1 67  ? 59.417 19.747 -9.688  1.000 18.171 ? 396 TYR EEE C   1 ? 
ATOM   501  O O   . TYR A 1 67  ? 60.299 19.429 -10.502 1.000 20.430 ? 396 TYR EEE O   1 ? 
ATOM   502  C CB  . TYR A 1 67  ? 59.518 22.282 -9.427  1.000 20.307 ? 396 TYR EEE CB  1 ? 
ATOM   503  C CG  . TYR A 1 67  ? 59.836 23.421 -8.494  1.000 24.013 ? 396 TYR EEE CG  1 ? 
ATOM   504  C CD1 . TYR A 1 67  ? 58.877 23.927 -7.631  1.000 26.158 ? 396 TYR EEE CD1 1 ? 
ATOM   505  C CD2 . TYR A 1 67  ? 61.115 23.944 -8.437  1.000 30.853 ? 396 TYR EEE CD2 1 ? 
ATOM   506  C CE1 . TYR A 1 67  ? 59.178 24.960 -6.756  1.000 28.027 ? 396 TYR EEE CE1 1 ? 
ATOM   507  C CE2 . TYR A 1 67  ? 61.433 24.972 -7.566  1.000 31.543 ? 396 TYR EEE CE2 1 ? 
ATOM   508  C CZ  . TYR A 1 67  ? 60.462 25.479 -6.722  1.000 31.645 ? 396 TYR EEE CZ  1 ? 
ATOM   509  O OH  . TYR A 1 67  ? 60.803 26.489 -5.870  1.000 36.361 ? 396 TYR EEE OH  1 ? 
ATOM   510  N N   . ALA A 1 68  ? 58.267 19.101 -9.521  1.000 17.951 ? 397 ALA EEE N   1 ? 
ATOM   511  C CA  . ALA A 1 68  ? 57.808 17.975 -10.359 1.000 15.942 ? 397 ALA EEE CA  1 ? 
ATOM   512  C C   . ALA A 1 68  ? 56.569 18.437 -11.119 1.000 15.703 ? 397 ALA EEE C   1 ? 
ATOM   513  O O   . ALA A 1 68  ? 55.511 18.613 -10.495 1.000 17.083 ? 397 ALA EEE O   1 ? 
ATOM   514  C CB  . ALA A 1 68  ? 57.524 16.757 -9.508  1.000 17.695 ? 397 ALA EEE CB  1 ? 
ATOM   515  N N   . ASP A 1 69  ? 56.728 18.676 -12.416 1.000 15.781 ? 398 ASP EEE N   1 ? 
ATOM   516  C CA  . ASP A 1 69  ? 55.623 19.086 -13.316 1.000 15.839 ? 398 ASP EEE CA  1 ? 
ATOM   517  C C   . ASP A 1 69  ? 55.119 17.841 -14.033 1.000 15.800 ? 398 ASP EEE C   1 ? 
ATOM   518  O O   . ASP A 1 69  ? 55.958 17.048 -14.485 1.000 17.150 ? 398 ASP EEE O   1 ? 
ATOM   519  C CB  . ASP A 1 69  ? 56.085 20.141 -14.311 1.000 16.035 ? 398 ASP EEE CB  1 ? 
ATOM   520  C CG  . ASP A 1 69  ? 56.594 21.394 -13.622 1.000 16.513 ? 398 ASP EEE CG  1 ? 
ATOM   521  O OD1 . ASP A 1 69  ? 56.191 21.617 -12.453 1.000 17.854 ? 398 ASP EEE OD1 1 ? 
ATOM   522  O OD2 . ASP A 1 69  ? 57.406 22.104 -14.233 1.000 17.511 ? 398 ASP EEE OD2 1 ? 
ATOM   523  N N   . SER A 1 70  ? 53.812 17.653 -14.148 1.000 13.720 ? 399 SER EEE N   1 ? 
ATOM   524  C CA  . SER A 1 70  ? 53.308 16.404 -14.763 1.000 14.852 ? 399 SER EEE CA  1 ? 
ATOM   525  C C   . SER A 1 70  ? 52.049 16.662 -15.590 1.000 14.664 ? 399 SER EEE C   1 ? 
ATOM   526  O O   . SER A 1 70  ? 51.270 17.592 -15.283 1.000 14.564 ? 399 SER EEE O   1 ? 
ATOM   527  C CB  . SER A 1 70  ? 53.103 15.327 -13.732 1.000 15.646 ? 399 SER EEE CB  1 ? 
ATOM   528  O OG  . SER A 1 70  ? 52.144 15.701 -12.760 1.000 16.860 ? 399 SER EEE OG  1 ? 
ATOM   529  N N   . PHE A 1 71  ? 51.896 15.867 -16.636 1.000 12.902 ? 400 PHE EEE N   1 ? 
ATOM   530  C CA  . PHE A 1 71  ? 50.835 16.034 -17.649 1.000 12.264 ? 400 PHE EEE CA  1 ? 
ATOM   531  C C   . PHE A 1 71  ? 50.898 14.870 -18.632 1.000 13.872 ? 400 PHE EEE C   1 ? 
ATOM   532  O O   . PHE A 1 71  ? 51.865 14.070 -18.600 1.000 13.863 ? 400 PHE EEE O   1 ? 
ATOM   533  C CB  . PHE A 1 71  ? 51.002 17.368 -18.379 1.000 14.176 ? 400 PHE EEE CB  1 ? 
ATOM   534  C CG  . PHE A 1 71  ? 52.375 17.589 -18.952 1.000 13.159 ? 400 PHE EEE CG  1 ? 
ATOM   535  C CD1 . PHE A 1 71  ? 52.753 17.017 -20.159 1.000 14.312 ? 400 PHE EEE CD1 1 ? 
ATOM   536  C CD2 . PHE A 1 71  ? 53.303 18.361 -18.273 1.000 13.475 ? 400 PHE EEE CD2 1 ? 
ATOM   537  C CE1 . PHE A 1 71  ? 54.024 17.215 -20.669 1.000 14.810 ? 400 PHE EEE CE1 1 ? 
ATOM   538  C CE2 . PHE A 1 71  ? 54.570 18.567 -18.790 1.000 14.743 ? 400 PHE EEE CE2 1 ? 
ATOM   539  C CZ  . PHE A 1 71  ? 54.928 18.002 -19.989 1.000 14.818 ? 400 PHE EEE CZ  1 ? 
ATOM   540  N N   . VAL A 1 72  ? 49.901 14.825 -19.510 1.000 13.571 ? 401 VAL EEE N   1 ? 
ATOM   541  C CA  . VAL A 1 72  ? 49.806 13.824 -20.602 1.000 14.066 ? 401 VAL EEE CA  1 ? 
ATOM   542  C C   . VAL A 1 72  ? 49.880 14.531 -21.957 1.000 13.745 ? 401 VAL EEE C   1 ? 
ATOM   543  O O   . VAL A 1 72  ? 49.212 15.570 -22.146 1.000 14.391 ? 401 VAL EEE O   1 ? 
ATOM   544  C CB  . VAL A 1 72  ? 48.512 13.001 -20.467 1.000 14.847 ? 401 VAL EEE CB  1 ? 
ATOM   545  C CG1 . VAL A 1 72  ? 48.213 12.218 -21.732 1.000 14.878 ? 401 VAL EEE CG1 1 ? 
ATOM   546  C CG2 . VAL A 1 72  ? 48.578 12.075 -19.267 1.000 15.912 ? 401 VAL EEE CG2 1 ? 
ATOM   547  N N   . ILE A 1 73  ? 50.672 13.969 -22.865 1.000 13.026 ? 402 ILE EEE N   1 ? 
ATOM   548  C CA  . ILE A 1 73  ? 50.747 14.390 -24.292 1.000 12.998 ? 402 ILE EEE CA  1 ? 
ATOM   549  C C   . ILE A 1 73  ? 50.775 13.128 -25.144 1.000 14.387 ? 402 ILE EEE C   1 ? 
ATOM   550  O O   . ILE A 1 73  ? 50.830 12.021 -24.595 1.000 15.426 ? 402 ILE EEE O   1 ? 
ATOM   551  C CB  . ILE A 1 73  ? 51.977 15.264 -24.574 1.000 14.244 ? 402 ILE EEE CB  1 ? 
ATOM   552  C CG1 . ILE A 1 73  ? 53.268 14.570 -24.141 1.000 15.028 ? 402 ILE EEE CG1 1 ? 
ATOM   553  C CG2 . ILE A 1 73  ? 51.806 16.640 -23.952 1.000 13.064 ? 402 ILE EEE CG2 1 ? 
ATOM   554  C CD1 . ILE A 1 73  ? 54.522 15.367 -24.406 1.000 16.469 ? 402 ILE EEE CD1 1 ? 
ATOM   555  N N   . ARG A 1 74  ? 50.748 13.276 -26.458 1.000 14.066 ? 403 ARG EEE N   1 ? 
ATOM   556  C CA  . ARG A 1 74  ? 50.915 12.082 -27.318 1.000 16.290 ? 403 ARG EEE CA  1 ? 
ATOM   557  C C   . ARG A 1 74  ? 52.404 11.739 -27.479 1.000 15.351 ? 403 ARG EEE C   1 ? 
ATOM   558  O O   . ARG A 1 74  ? 53.294 12.593 -27.288 1.000 16.215 ? 403 ARG EEE O   1 ? 
ATOM   559  C CB  . ARG A 1 74  ? 50.138 12.226 -28.629 1.000 21.742 ? 403 ARG EEE CB  1 ? 
ATOM   560  C CG  . ARG A 1 74  ? 50.457 13.460 -29.444 1.000 26.499 ? 403 ARG EEE CG  1 ? 
ATOM   561  C CD  . ARG A 1 74  ? 49.443 13.622 -30.558 1.000 23.875 ? 403 ARG EEE CD  1 ? 
ATOM   562  N NE  . ARG A 1 74  ? 49.824 12.784 -31.672 1.000 26.990 ? 403 ARG EEE NE  1 ? 
ATOM   563  C CZ  . ARG A 1 74  ? 49.122 12.626 -32.788 1.000 28.974 ? 403 ARG EEE CZ  1 ? 
ATOM   564  N NH1 . ARG A 1 74  ? 47.968 13.253 -32.945 1.000 26.552 ? 403 ARG EEE NH1 1 ? 
ATOM   565  N NH2 . ARG A 1 74  ? 49.586 11.837 -33.744 1.000 30.270 ? 403 ARG EEE NH2 1 ? 
ATOM   566  N N   . GLY A 1 75  ? 52.672 10.469 -27.773 1.000 15.956 ? 404 GLY EEE N   1 ? 
ATOM   567  C CA  . GLY A 1 75  ? 54.039 9.931  -27.887 1.000 16.612 ? 404 GLY EEE CA  1 ? 
ATOM   568  C C   . GLY A 1 75  ? 54.903 10.776 -28.804 1.000 15.891 ? 404 GLY EEE C   1 ? 
ATOM   569  O O   . GLY A 1 75  ? 56.069 11.016 -28.459 1.000 16.724 ? 404 GLY EEE O   1 ? 
ATOM   570  N N   . ASP A 1 76  ? 54.365 11.231 -29.930 1.000 17.271 ? 405 ASP EEE N   1 ? 
ATOM   571  C CA  . ASP A 1 76  ? 55.196 11.906 -30.960 1.000 17.150 ? 405 ASP EEE CA  1 ? 
ATOM   572  C C   . ASP A 1 76  ? 55.460 13.362 -30.550 1.000 17.332 ? 405 ASP EEE C   1 ? 
ATOM   573  O O   . ASP A 1 76  ? 56.182 14.056 -31.287 1.000 18.857 ? 405 ASP EEE O   1 ? 
ATOM   574  C CB  . ASP A 1 76  ? 54.603 11.744 -32.364 1.000 20.351 ? 405 ASP EEE CB  1 ? 
ATOM   575  C CG  . ASP A 1 76  ? 53.245 12.380 -32.584 1.000 25.546 ? 405 ASP EEE CG  1 ? 
ATOM   576  O OD1 . ASP A 1 76  ? 52.818 13.187 -31.727 1.000 24.752 ? 405 ASP EEE OD1 1 ? 
ATOM   577  O OD2 . ASP A 1 76  ? 52.617 12.054 -33.616 1.000 27.426 ? 405 ASP EEE OD2 1 ? 
ATOM   578  N N   . GLU A 1 77  ? 54.946 13.805 -29.396 1.000 15.282 ? 406 GLU EEE N   1 ? 
ATOM   579  C CA  . GLU A 1 77  ? 55.194 15.168 -28.867 1.000 13.816 ? 406 GLU EEE CA  1 ? 
ATOM   580  C C   . GLU A 1 77  ? 56.204 15.154 -27.718 1.000 13.998 ? 406 GLU EEE C   1 ? 
ATOM   581  O O   . GLU A 1 77  ? 56.606 16.242 -27.302 1.000 14.893 ? 406 GLU EEE O   1 ? 
ATOM   582  C CB  . GLU A 1 77  ? 53.889 15.807 -28.398 1.000 15.494 ? 406 GLU EEE CB  1 ? 
ATOM   583  C CG  . GLU A 1 77  ? 52.956 16.131 -29.538 1.000 16.671 ? 406 GLU EEE CG  1 ? 
ATOM   584  C CD  . GLU A 1 77  ? 51.558 16.513 -29.089 1.000 17.174 ? 406 GLU EEE CD  1 ? 
ATOM   585  O OE1 . GLU A 1 77  ? 51.155 16.097 -27.979 1.000 17.960 ? 406 GLU EEE OE1 1 ? 
ATOM   586  O OE2 . GLU A 1 77  ? 50.885 17.221 -29.844 1.000 19.569 ? 406 GLU EEE OE2 1 ? 
ATOM   587  N N   . VAL A 1 78  ? 56.598 13.989 -27.215 1.000 14.633 ? 407 VAL EEE N   1 ? 
ATOM   588  C CA  . VAL A 1 78  ? 57.537 13.917 -26.054 1.000 15.388 ? 407 VAL EEE CA  1 ? 
ATOM   589  C C   . VAL A 1 78  ? 58.844 14.642 -26.422 1.000 14.574 ? 407 VAL EEE C   1 ? 
ATOM   590  O O   . VAL A 1 78  ? 59.434 15.287 -25.531 1.000 16.270 ? 407 VAL EEE O   1 ? 
ATOM   591  C CB  . VAL A 1 78  ? 57.737 12.462 -25.594 1.000 16.341 ? 407 VAL EEE CB  1 ? 
ATOM   592  C CG1 . VAL A 1 78  ? 58.855 12.346 -24.568 1.000 19.117 ? 407 VAL EEE CG1 1 ? 
ATOM   593  C CG2 . VAL A 1 78  ? 56.437 11.881 -25.033 1.000 16.945 ? 407 VAL EEE CG2 1 ? 
ATOM   594  N N   . ARG A 1 79  ? 59.253 14.595 -27.693 1.000 15.121 ? 408 ARG EEE N   1 ? 
ATOM   595  C CA  . ARG A 1 79  ? 60.491 15.270 -28.179 1.000 16.150 ? 408 ARG EEE CA  1 ? 
ATOM   596  C C   . ARG A 1 79  ? 60.417 16.791 -27.953 1.000 16.377 ? 408 ARG EEE C   1 ? 
ATOM   597  O O   . ARG A 1 79  ? 61.493 17.428 -27.863 1.000 17.419 ? 408 ARG EEE O   1 ? 
ATOM   598  C CB  . ARG A 1 79  ? 60.742 14.916 -29.647 1.000 18.726 ? 408 ARG EEE CB  1 ? 
ATOM   599  C CG  . ARG A 1 79  ? 59.718 15.483 -30.619 1.000 19.949 ? 408 ARG EEE CG  1 ? 
ATOM   600  C CD  . ARG A 1 79  ? 60.273 16.668 -31.387 1.000 27.005 ? 408 ARG EEE CD  1 ? 
ATOM   601  N NE  . ARG A 1 79  ? 59.217 17.302 -32.157 1.000 30.047 ? 408 ARG EEE NE  1 ? 
ATOM   602  C CZ  . ARG A 1 79  ? 59.169 18.580 -32.485 1.000 26.475 ? 408 ARG EEE CZ  1 ? 
ATOM   603  N NH1 . ARG A 1 79  ? 60.135 19.411 -32.120 1.000 30.409 ? 408 ARG EEE NH1 1 ? 
ATOM   604  N NH2 . ARG A 1 79  ? 58.146 19.032 -33.188 1.000 31.290 ? 408 ARG EEE NH2 1 ? 
ATOM   605  N N   . GLN A 1 80  ? 59.215 17.367 -27.815 1.000 15.194 ? 409 GLN EEE N   1 ? 
ATOM   606  C CA  . GLN A 1 80  ? 59.024 18.826 -27.614 1.000 14.643 ? 409 GLN EEE CA  1 ? 
ATOM   607  C C   . GLN A 1 80  ? 59.313 19.226 -26.164 1.000 14.730 ? 409 GLN EEE C   1 ? 
ATOM   608  O O   . GLN A 1 80  ? 59.469 20.440 -25.902 1.000 15.878 ? 409 GLN EEE O   1 ? 
ATOM   609  C CB  . GLN A 1 80  ? 57.604 19.251 -27.980 1.000 15.078 ? 409 GLN EEE CB  1 ? 
ATOM   610  C CG  . GLN A 1 80  ? 57.304 19.123 -29.460 1.000 16.310 ? 409 GLN EEE CG  1 ? 
ATOM   611  C CD  . GLN A 1 80  ? 55.967 19.717 -29.830 1.000 15.505 ? 409 GLN EEE CD  1 ? 
ATOM   612  O OE1 . GLN A 1 80  ? 55.579 20.784 -29.348 1.000 15.924 ? 409 GLN EEE OE1 1 ? 
ATOM   613  N NE2 . GLN A 1 80  ? 55.258 19.034 -30.715 1.000 16.864 ? 409 GLN EEE NE2 1 ? 
ATOM   614  N N   . ILE A 1 81  ? 59.331 18.268 -25.234 1.000 14.414 ? 410 ILE EEE N   1 ? 
ATOM   615  C CA  . ILE A 1 81  ? 59.610 18.561 -23.798 1.000 15.469 ? 410 ILE EEE CA  1 ? 
ATOM   616  C C   . ILE A 1 81  ? 61.131 18.522 -23.613 1.000 15.827 ? 410 ILE EEE C   1 ? 
ATOM   617  O O   . ILE A 1 81  ? 61.690 17.577 -23.010 1.000 17.917 ? 410 ILE EEE O   1 ? 
ATOM   618  C CB  . ILE A 1 81  ? 58.850 17.618 -22.850 1.000 15.133 ? 410 ILE EEE CB  1 ? 
ATOM   619  C CG1 . ILE A 1 81  ? 57.378 17.462 -23.245 1.000 14.967 ? 410 ILE EEE CG1 1 ? 
ATOM   620  C CG2 . ILE A 1 81  ? 58.986 18.096 -21.416 1.000 14.792 ? 410 ILE EEE CG2 1 ? 
ATOM   621  C CD1 . ILE A 1 81  ? 56.625 18.766 -23.389 1.000 16.649 ? 410 ILE EEE CD1 1 ? 
ATOM   622  N N   . ALA A 1 82  ? 61.791 19.511 -24.189 1.000 14.997 ? 411 ALA EEE N   1 ? 
ATOM   623  C CA  . ALA A 1 82  ? 63.258 19.608 -24.223 1.000 15.746 ? 411 ALA EEE CA  1 ? 
ATOM   624  C C   . ALA A 1 82  ? 63.603 21.070 -24.442 1.000 15.988 ? 411 ALA EEE C   1 ? 
ATOM   625  O O   . ALA A 1 82  ? 62.879 21.769 -25.149 1.000 16.685 ? 411 ALA EEE O   1 ? 
ATOM   626  C CB  . ALA A 1 82  ? 63.810 18.729 -25.319 1.000 15.304 ? 411 ALA EEE CB  1 ? 
ATOM   627  N N   . PRO A 1 83  ? 64.698 21.578 -23.842 1.000 16.064 ? 412 PRO EEE N   1 ? 
ATOM   628  C CA  . PRO A 1 83  ? 65.093 22.965 -24.047 1.000 17.338 ? 412 PRO EEE CA  1 ? 
ATOM   629  C C   . PRO A 1 83  ? 65.261 23.254 -25.539 1.000 17.440 ? 412 PRO EEE C   1 ? 
ATOM   630  O O   . PRO A 1 83  ? 65.808 22.417 -26.248 1.000 19.691 ? 412 PRO EEE O   1 ? 
ATOM   631  C CB  . PRO A 1 83  ? 66.429 23.095 -23.316 1.000 18.239 ? 412 PRO EEE CB  1 ? 
ATOM   632  C CG  . PRO A 1 83  ? 66.394 21.982 -22.295 1.000 19.631 ? 412 PRO EEE CG  1 ? 
ATOM   633  C CD  . PRO A 1 83  ? 65.605 20.861 -22.930 1.000 15.898 ? 412 PRO EEE CD  1 ? 
ATOM   634  N N   . GLY A 1 84  ? 64.735 24.398 -25.970 1.000 19.162 ? 413 GLY EEE N   1 ? 
ATOM   635  C CA  . GLY A 1 84  ? 64.955 24.945 -27.319 1.000 20.288 ? 413 GLY EEE CA  1 ? 
ATOM   636  C C   . GLY A 1 84  ? 64.072 24.318 -28.379 1.000 21.712 ? 413 GLY EEE C   1 ? 
ATOM   637  O O   . GLY A 1 84  ? 64.180 24.752 -29.528 1.000 22.888 ? 413 GLY EEE O   1 ? 
ATOM   638  N N   . GLN A 1 85  ? 63.218 23.344 -28.046 1.000 19.533 ? 414 GLN EEE N   1 ? 
ATOM   639  C CA  . GLN A 1 85  ? 62.348 22.712 -29.070 1.000 20.035 ? 414 GLN EEE CA  1 ? 
ATOM   640  C C   . GLN A 1 85  ? 61.158 23.624 -29.386 1.000 19.608 ? 414 GLN EEE C   1 ? 
ATOM   641  O O   . GLN A 1 85  ? 60.828 24.527 -28.587 1.000 23.274 ? 414 GLN EEE O   1 ? 
ATOM   642  C CB  . GLN A 1 85  ? 61.929 21.305 -28.651 1.000 18.830 ? 414 GLN EEE CB  1 ? 
ATOM   643  C CG  . GLN A 1 85  ? 63.049 20.287 -28.786 1.000 21.329 ? 414 GLN EEE CG  1 ? 
ATOM   644  C CD  . GLN A 1 85  ? 63.326 19.872 -30.213 1.000 23.166 ? 414 GLN EEE CD  1 ? 
ATOM   645  O OE1 . GLN A 1 85  ? 62.538 19.155 -30.828 1.000 28.492 ? 414 GLN EEE OE1 1 ? 
ATOM   646  N NE2 . GLN A 1 85  ? 64.458 20.305 -30.749 1.000 23.328 ? 414 GLN EEE NE2 1 ? 
ATOM   647  N N   . THR A 1 86  ? 60.572 23.429 -30.566 1.000 20.033 ? 415 THR EEE N   1 ? 
ATOM   648  C CA  . THR A 1 86  ? 59.378 24.175 -31.036 1.000 22.234 ? 415 THR EEE CA  1 ? 
ATOM   649  C C   . THR A 1 86  ? 58.309 23.166 -31.441 1.000 20.452 ? 415 THR EEE C   1 ? 
ATOM   650  O O   . THR A 1 86  ? 58.640 21.998 -31.701 1.000 22.389 ? 415 THR EEE O   1 ? 
ATOM   651  C CB  . THR A 1 86  ? 59.688 25.119 -32.206 1.000 28.439 ? 415 THR EEE CB  1 ? 
ATOM   652  O OG1 . THR A 1 86  ? 60.100 24.327 -33.319 1.000 33.082 ? 415 THR EEE OG1 1 ? 
ATOM   653  C CG2 . THR A 1 86  ? 60.755 26.141 -31.882 1.000 34.320 ? 415 THR EEE CG2 1 ? 
ATOM   654  N N   . GLY A 1 87  ? 57.077 23.639 -31.529 1.000 20.355 ? 416 GLY EEE N   1 ? 
ATOM   655  C CA  . GLY A 1 87  ? 55.906 22.809 -31.839 1.000 18.772 ? 416 GLY EEE CA  1 ? 
ATOM   656  C C   . GLY A 1 87  ? 54.747 23.244 -30.977 1.000 17.429 ? 416 GLY EEE C   1 ? 
ATOM   657  O O   . GLY A 1 87  ? 54.946 24.085 -30.104 1.000 15.956 ? 416 GLY EEE O   1 ? 
ATOM   658  N N   . LYS A 1 88  ? 53.556 22.706 -31.212 1.000 18.227 ? 417 LYS EEE N   1 ? 
ATOM   659  C CA  . LYS A 1 88  ? 52.337 23.213 -30.542 1.000 18.330 ? 417 LYS EEE CA  1 ? 
ATOM   660  C C   . LYS A 1 88  ? 52.471 23.069 -29.023 1.000 15.779 ? 417 LYS EEE C   1 ? 
ATOM   661  O O   . LYS A 1 88  ? 51.952 23.917 -28.291 1.000 15.168 ? 417 LYS EEE O   1 ? 
ATOM   662  C CB  . LYS A 1 88  ? 51.104 22.454 -31.033 1.000 24.815 ? 417 LYS EEE CB  1 ? 
ATOM   663  C CG  . LYS A 1 88  ? 49.796 23.218 -30.894 1.000 31.058 ? 417 LYS EEE CG  1 ? 
ATOM   664  C CD  . LYS A 1 88  ? 49.725 24.463 -31.758 1.000 38.215 ? 417 LYS EEE CD  1 ? 
ATOM   665  C CE  . LYS A 1 88  ? 49.787 24.173 -33.241 1.000 45.630 ? 417 LYS EEE CE  1 ? 
ATOM   666  N NZ  . LYS A 1 88  ? 50.032 25.402 -34.030 1.000 53.733 ? 417 LYS EEE NZ  1 ? 
ATOM   667  N N   . ILE A 1 89  ? 53.113 22.003 -28.549 1.000 15.155 ? 418 ILE EEE N   1 ? 
ATOM   668  C CA  . ILE A 1 89  ? 53.202 21.753 -27.084 1.000 15.425 ? 418 ILE EEE CA  1 ? 
ATOM   669  C C   . ILE A 1 89  ? 54.228 22.716 -26.483 1.000 15.215 ? 418 ILE EEE C   1 ? 
ATOM   670  O O   . ILE A 1 89  ? 53.878 23.408 -25.516 1.000 15.249 ? 418 ILE EEE O   1 ? 
ATOM   671  C CB  . ILE A 1 89  ? 53.488 20.276 -26.770 1.000 15.683 ? 418 ILE EEE CB  1 ? 
ATOM   672  C CG1 . ILE A 1 89  ? 52.412 19.364 -27.371 1.000 16.435 ? 418 ILE EEE CG1 1 ? 
ATOM   673  C CG2 . ILE A 1 89  ? 53.639 20.071 -25.265 1.000 15.697 ? 418 ILE EEE CG2 1 ? 
ATOM   674  C CD1 . ILE A 1 89  ? 50.995 19.693 -26.945 1.000 17.850 ? 418 ILE EEE CD1 1 ? 
ATOM   675  N N   . ALA A 1 90  ? 55.449 22.770 -27.017 1.000 14.188 ? 419 ALA EEE N   1 ? 
ATOM   676  C CA  . ALA A 1 90  ? 56.491 23.680 -26.486 1.000 15.657 ? 419 ALA EEE CA  1 ? 
ATOM   677  C C   . ALA A 1 90  ? 56.003 25.130 -26.599 1.000 17.566 ? 419 ALA EEE C   1 ? 
ATOM   678  O O   . ALA A 1 90  ? 56.227 25.921 -25.661 1.000 18.462 ? 419 ALA EEE O   1 ? 
ATOM   679  C CB  . ALA A 1 90  ? 57.807 23.468 -27.202 1.000 16.978 ? 419 ALA EEE CB  1 ? 
ATOM   680  N N   . ASP A 1 91  ? 55.336 25.483 -27.702 1.000 15.129 ? 420 ASP EEE N   1 ? 
ATOM   681  C CA  . ASP A 1 91  ? 54.975 26.895 -27.980 1.000 16.508 ? 420 ASP EEE CA  1 ? 
ATOM   682  C C   . ASP A 1 91  ? 53.798 27.336 -27.107 1.000 15.947 ? 420 ASP EEE C   1 ? 
ATOM   683  O O   . ASP A 1 91  ? 53.848 28.448 -26.581 1.000 17.732 ? 420 ASP EEE O   1 ? 
ATOM   684  C CB  . ASP A 1 91  ? 54.630 27.124 -29.450 1.000 19.384 ? 420 ASP EEE CB  1 ? 
ATOM   685  C CG  . ASP A 1 91  ? 55.765 26.884 -30.433 1.000 24.530 ? 420 ASP EEE CG  1 ? 
ATOM   686  O OD1 . ASP A 1 91  ? 56.910 26.638 -29.988 1.000 24.260 ? 420 ASP EEE OD1 1 ? 
ATOM   687  O OD2 . ASP A 1 91  ? 55.483 26.934 -31.643 1.000 25.703 ? 420 ASP EEE OD2 1 ? 
ATOM   688  N N   . TYR A 1 92  ? 52.742 26.526 -26.995 1.000 15.519 ? 421 TYR EEE N   1 ? 
ATOM   689  C CA  . TYR A 1 92  ? 51.444 26.984 -26.452 1.000 14.984 ? 421 TYR EEE CA  1 ? 
ATOM   690  C C   . TYR A 1 92  ? 51.030 26.247 -25.177 1.000 14.790 ? 421 TYR EEE C   1 ? 
ATOM   691  O O   . TYR A 1 92  ? 50.008 26.674 -24.603 1.000 15.281 ? 421 TYR EEE O   1 ? 
ATOM   692  C CB  . TYR A 1 92  ? 50.315 26.827 -27.473 1.000 14.553 ? 421 TYR EEE CB  1 ? 
ATOM   693  C CG  . TYR A 1 92  ? 50.416 27.659 -28.729 1.000 15.571 ? 421 TYR EEE CG  1 ? 
ATOM   694  C CD1 . TYR A 1 92  ? 51.274 28.743 -28.836 1.000 18.728 ? 421 TYR EEE CD1 1 ? 
ATOM   695  C CD2 . TYR A 1 92  ? 49.586 27.384 -29.800 1.000 16.807 ? 421 TYR EEE CD2 1 ? 
ATOM   696  C CE1 . TYR A 1 92  ? 51.341 29.493 -30.000 1.000 18.075 ? 421 TYR EEE CE1 1 ? 
ATOM   697  C CE2 . TYR A 1 92  ? 49.632 28.129 -30.962 1.000 19.383 ? 421 TYR EEE CE2 1 ? 
ATOM   698  C CZ  . TYR A 1 92  ? 50.509 29.191 -31.063 1.000 19.729 ? 421 TYR EEE CZ  1 ? 
ATOM   699  O OH  . TYR A 1 92  ? 50.536 29.928 -32.216 1.000 20.210 ? 421 TYR EEE OH  1 ? 
ATOM   700  N N   . ASN A 1 93  ? 51.755 25.218 -24.723 1.000 14.876 ? 422 ASN EEE N   1 ? 
ATOM   701  C CA  . ASN A 1 93  ? 51.256 24.362 -23.607 1.000 14.297 ? 422 ASN EEE CA  1 ? 
ATOM   702  C C   . ASN A 1 93  ? 52.249 24.257 -22.446 1.000 13.744 ? 422 ASN EEE C   1 ? 
ATOM   703  O O   . ASN A 1 93  ? 51.830 24.496 -21.301 1.000 15.034 ? 422 ASN EEE O   1 ? 
ATOM   704  C CB  . ASN A 1 93  ? 50.857 22.981 -24.127 1.000 14.404 ? 422 ASN EEE CB  1 ? 
ATOM   705  C CG  . ASN A 1 93  ? 49.615 23.055 -24.983 1.000 14.577 ? 422 ASN EEE CG  1 ? 
ATOM   706  O OD1 . ASN A 1 93  ? 48.516 22.897 -24.461 1.000 13.584 ? 422 ASN EEE OD1 1 ? 
ATOM   707  N ND2 . ASN A 1 93  ? 49.776 23.341 -26.270 1.000 14.293 ? 422 ASN EEE ND2 1 ? 
ATOM   708  N N   . TYR A 1 94  ? 53.485 23.854 -22.715 1.000 13.429 ? 423 TYR EEE N   1 ? 
ATOM   709  C CA  . TYR A 1 94  ? 54.507 23.621 -21.667 1.000 14.381 ? 423 TYR EEE CA  1 ? 
ATOM   710  C C   . TYR A 1 94  ? 55.888 23.883 -22.258 1.000 15.459 ? 423 TYR EEE C   1 ? 
ATOM   711  O O   . TYR A 1 94  ? 56.299 23.173 -23.202 1.000 14.992 ? 423 TYR EEE O   1 ? 
ATOM   712  C CB  . TYR A 1 94  ? 54.411 22.215 -21.075 1.000 13.633 ? 423 TYR EEE CB  1 ? 
ATOM   713  C CG  . TYR A 1 94  ? 55.369 22.014 -19.929 1.000 13.701 ? 423 TYR EEE CG  1 ? 
ATOM   714  C CD1 . TYR A 1 94  ? 55.031 22.392 -18.644 1.000 14.576 ? 423 TYR EEE CD1 1 ? 
ATOM   715  C CD2 . TYR A 1 94  ? 56.646 21.524 -20.143 1.000 14.432 ? 423 TYR EEE CD2 1 ? 
ATOM   716  C CE1 . TYR A 1 94  ? 55.917 22.254 -17.589 1.000 13.384 ? 423 TYR EEE CE1 1 ? 
ATOM   717  C CE2 . TYR A 1 94  ? 57.545 21.371 -19.099 1.000 14.516 ? 423 TYR EEE CE2 1 ? 
ATOM   718  C CZ  . TYR A 1 94  ? 57.176 21.727 -17.817 1.000 14.180 ? 423 TYR EEE CZ  1 ? 
ATOM   719  O OH  . TYR A 1 94  ? 58.068 21.587 -16.786 1.000 15.860 ? 423 TYR EEE OH  1 ? 
ATOM   720  N N   . LYS A 1 95  ? 56.558 24.897 -21.716 1.000 15.016 ? 424 LYS EEE N   1 ? 
ATOM   721  C CA  . LYS A 1 95  ? 57.824 25.426 -22.269 1.000 15.686 ? 424 LYS EEE CA  1 ? 
ATOM   722  C C   . LYS A 1 95  ? 58.941 25.306 -21.233 1.000 14.809 ? 424 LYS EEE C   1 ? 
ATOM   723  O O   . LYS A 1 95  ? 58.803 25.893 -20.151 1.000 16.290 ? 424 LYS EEE O   1 ? 
ATOM   724  C CB  . LYS A 1 95  ? 57.642 26.886 -22.687 1.000 16.735 ? 424 LYS EEE CB  1 ? 
ATOM   725  C CG  . LYS A 1 95  ? 58.863 27.542 -23.320 1.000 18.127 ? 424 LYS EEE CG  1 ? 
ATOM   726  C CD  . LYS A 1 95  ? 59.478 26.740 -24.431 1.000 18.664 ? 424 LYS EEE CD  1 ? 
ATOM   727  C CE  . LYS A 1 95  ? 60.533 27.488 -25.217 1.000 20.900 ? 424 LYS EEE CE  1 ? 
ATOM   728  N NZ  . LYS A 1 95  ? 61.023 26.669 -26.350 1.000 23.870 ? 424 LYS EEE NZ  1 ? 
ATOM   729  N N   . LEU A 1 96  ? 60.000 24.576 -21.574 1.000 16.285 ? 425 LEU EEE N   1 ? 
ATOM   730  C CA  . LEU A 1 96  ? 61.229 24.532 -20.742 1.000 16.071 ? 425 LEU EEE CA  1 ? 
ATOM   731  C C   . LEU A 1 96  ? 62.101 25.716 -21.111 1.000 18.528 ? 425 LEU EEE C   1 ? 
ATOM   732  O O   . LEU A 1 96  ? 62.129 26.145 -22.262 1.000 18.685 ? 425 LEU EEE O   1 ? 
ATOM   733  C CB  . LEU A 1 96  ? 61.991 23.231 -20.978 1.000 16.670 ? 425 LEU EEE CB  1 ? 
ATOM   734  C CG  . LEU A 1 96  ? 61.323 21.972 -20.438 1.000 17.143 ? 425 LEU EEE CG  1 ? 
ATOM   735  C CD1 . LEU A 1 96  ? 62.114 20.740 -20.843 1.000 18.939 ? 425 LEU EEE CD1 1 ? 
ATOM   736  C CD2 . LEU A 1 96  ? 61.190 22.040 -18.927 1.000 19.259 ? 425 LEU EEE CD2 1 ? 
ATOM   737  N N   . PRO A 1 97  ? 62.843 26.258 -20.127 1.000 18.978 ? 426 PRO EEE N   1 ? 
ATOM   738  C CA  . PRO A 1 97  ? 63.826 27.307 -20.400 1.000 19.798 ? 426 PRO EEE CA  1 ? 
ATOM   739  C C   . PRO A 1 97  ? 65.056 26.778 -21.146 1.000 21.796 ? 426 PRO EEE C   1 ? 
ATOM   740  O O   . PRO A 1 97  ? 65.367 25.595 -21.057 1.000 21.196 ? 426 PRO EEE O   1 ? 
ATOM   741  C CB  . PRO A 1 97  ? 64.230 27.775 -19.003 1.000 20.438 ? 426 PRO EEE CB  1 ? 
ATOM   742  C CG  . PRO A 1 97  ? 64.015 26.561 -18.138 1.000 19.603 ? 426 PRO EEE CG  1 ? 
ATOM   743  C CD  . PRO A 1 97  ? 62.779 25.891 -18.706 1.000 18.909 ? 426 PRO EEE CD  1 ? 
ATOM   744  N N   . ASP A 1 98  ? 65.749 27.673 -21.850 1.000 23.590 ? 427 ASP EEE N   1 ? 
ATOM   745  C CA  . ASP A 1 98  ? 66.985 27.341 -22.601 1.000 26.885 ? 427 ASP EEE CA  1 ? 
ATOM   746  C C   . ASP A 1 98  ? 68.016 26.780 -21.609 1.000 22.088 ? 427 ASP EEE C   1 ? 
ATOM   747  O O   . ASP A 1 98  ? 68.717 25.822 -21.976 1.000 26.594 ? 427 ASP EEE O   1 ? 
ATOM   748  C CB  . ASP A 1 98  ? 67.492 28.558 -23.388 1.000 28.137 ? 427 ASP EEE CB  1 ? 
ATOM   749  C CG  . ASP A 1 98  ? 66.556 29.039 -24.492 1.000 33.369 ? 427 ASP EEE CG  1 ? 
ATOM   750  O OD1 . ASP A 1 98  ? 65.603 28.305 -24.838 1.000 31.962 ? 427 ASP EEE OD1 1 ? 
ATOM   751  O OD2 . ASP A 1 98  ? 66.785 30.157 -25.002 1.000 34.226 ? 427 ASP EEE OD2 1 ? 
ATOM   752  N N   . ASP A 1 99  ? 68.041 27.300 -20.375 1.000 26.220 ? 428 ASP EEE N   1 ? 
ATOM   753  C CA  . ASP A 1 99  ? 69.052 26.987 -19.325 1.000 26.256 ? 428 ASP EEE CA  1 ? 
ATOM   754  C C   . ASP A 1 99  ? 68.527 25.938 -18.331 1.000 26.959 ? 428 ASP EEE C   1 ? 
ATOM   755  O O   . ASP A 1 99  ? 68.998 25.905 -17.177 1.000 26.918 ? 428 ASP EEE O   1 ? 
ATOM   756  C CB  . ASP A 1 99  ? 69.477 28.271 -18.601 1.000 28.323 ? 428 ASP EEE CB  1 ? 
ATOM   757  C CG  . ASP A 1 99  ? 68.423 28.878 -17.685 1.000 35.371 ? 428 ASP EEE CG  1 ? 
ATOM   758  O OD1 . ASP A 1 99  ? 67.244 28.457 -17.764 1.000 34.649 ? 428 ASP EEE OD1 1 ? 
ATOM   759  O OD2 . ASP A 1 99  ? 68.792 29.767 -16.886 1.000 40.702 ? 428 ASP EEE OD2 1 ? 
ATOM   760  N N   . PHE A 1 100 ? 67.615 25.072 -18.759 1.000 24.443 ? 429 PHE EEE N   1 ? 
ATOM   761  C CA  . PHE A 1 100 ? 66.980 24.044 -17.903 1.000 21.327 ? 429 PHE EEE CA  1 ? 
ATOM   762  C C   . PHE A 1 100 ? 68.042 23.151 -17.243 1.000 21.923 ? 429 PHE EEE C   1 ? 
ATOM   763  O O   . PHE A 1 100 ? 68.909 22.612 -17.956 1.000 23.504 ? 429 PHE EEE O   1 ? 
ATOM   764  C CB  . PHE A 1 100 ? 66.018 23.218 -18.756 1.000 20.571 ? 429 PHE EEE CB  1 ? 
ATOM   765  C CG  . PHE A 1 100 ? 65.319 22.119 -18.007 1.000 18.265 ? 429 PHE EEE CG  1 ? 
ATOM   766  C CD1 . PHE A 1 100 ? 64.543 22.404 -16.895 1.000 18.840 ? 429 PHE EEE CD1 1 ? 
ATOM   767  C CD2 . PHE A 1 100 ? 65.422 20.804 -18.430 1.000 18.498 ? 429 PHE EEE CD2 1 ? 
ATOM   768  C CE1 . PHE A 1 100 ? 63.902 21.386 -16.212 1.000 18.669 ? 429 PHE EEE CE1 1 ? 
ATOM   769  C CE2 . PHE A 1 100 ? 64.771 19.790 -17.746 1.000 18.668 ? 429 PHE EEE CE2 1 ? 
ATOM   770  C CZ  . PHE A 1 100 ? 64.017 20.086 -16.637 1.000 18.223 ? 429 PHE EEE CZ  1 ? 
ATOM   771  N N   . THR A 1 101 ? 67.950 23.024 -15.913 1.000 23.191 ? 430 THR EEE N   1 ? 
ATOM   772  C CA  . THR A 1 101 ? 68.644 22.015 -15.069 1.000 24.939 ? 430 THR EEE CA  1 ? 
ATOM   773  C C   . THR A 1 101 ? 67.595 21.053 -14.522 1.000 23.292 ? 430 THR EEE C   1 ? 
ATOM   774  O O   . THR A 1 101 ? 66.849 21.424 -13.583 1.000 23.336 ? 430 THR EEE O   1 ? 
ATOM   775  C CB  . THR A 1 101 ? 69.411 22.622 -13.889 1.000 25.842 ? 430 THR EEE CB  1 ? 
ATOM   776  O OG1 . THR A 1 101 ? 70.384 23.504 -14.442 1.000 27.100 ? 430 THR EEE OG1 1 ? 
ATOM   777  C CG2 . THR A 1 101 ? 70.099 21.582 -13.030 1.000 26.864 ? 430 THR EEE CG2 1 ? 
ATOM   778  N N   . GLY A 1 102 ? 67.533 19.863 -15.095 1.000 21.234 ? 431 GLY EEE N   1 ? 
ATOM   779  C CA  . GLY A 1 102 ? 66.564 18.872 -14.629 1.000 21.560 ? 431 GLY EEE CA  1 ? 
ATOM   780  C C   . GLY A 1 102 ? 66.477 17.688 -15.550 1.000 19.680 ? 431 GLY EEE C   1 ? 
ATOM   781  O O   . GLY A 1 102 ? 67.354 17.506 -16.426 1.000 20.326 ? 431 GLY EEE O   1 ? 
ATOM   782  N N   . CYS A 1 103 ? 65.434 16.902 -15.336 1.000 17.752 ? 432 CYS EEE N   1 ? 
ATOM   783  C CA  . CYS A 1 103 ? 65.223 15.617 -16.032 1.000 18.397 ? 432 CYS EEE CA  1 ? 
ATOM   784  C C   . CYS A 1 103 ? 63.801 15.586 -16.573 1.000 17.925 ? 432 CYS EEE C   1 ? 
ATOM   785  O O   . CYS A 1 103 ? 62.869 16.045 -15.879 1.000 18.423 ? 432 CYS EEE O   1 ? 
ATOM   786  C CB  . CYS A 1 103 ? 65.472 14.422 -15.122 1.000 20.893 ? 432 CYS EEE CB  1 ? 
ATOM   787  S SG  . CYS A 1 103 ? 67.176 14.356 -14.497 1.000 27.798 ? 432 CYS EEE SG  1 ? 
ATOM   788  N N   . VAL A 1 104 ? 63.671 15.065 -17.780 1.000 15.713 ? 433 VAL EEE N   1 ? 
ATOM   789  C CA  . VAL A 1 104 ? 62.372 14.801 -18.446 1.000 15.423 ? 433 VAL EEE CA  1 ? 
ATOM   790  C C   . VAL A 1 104 ? 62.187 13.291 -18.492 1.000 15.679 ? 433 VAL EEE C   1 ? 
ATOM   791  O O   . VAL A 1 104 ? 63.051 12.589 -19.057 1.000 17.164 ? 433 VAL EEE O   1 ? 
ATOM   792  C CB  . VAL A 1 104 ? 62.343 15.421 -19.850 1.000 15.361 ? 433 VAL EEE CB  1 ? 
ATOM   793  C CG1 . VAL A 1 104 ? 61.043 15.098 -20.567 1.000 16.962 ? 433 VAL EEE CG1 1 ? 
ATOM   794  C CG2 . VAL A 1 104 ? 62.590 16.921 -19.790 1.000 17.594 ? 433 VAL EEE CG2 1 ? 
ATOM   795  N N   . ILE A 1 105 ? 61.106 12.816 -17.891 1.000 14.966 ? 434 ILE EEE N   1 ? 
ATOM   796  C CA  . ILE A 1 105 ? 60.802 11.370 -17.759 1.000 14.478 ? 434 ILE EEE CA  1 ? 
ATOM   797  C C   . ILE A 1 105 ? 59.423 11.123 -18.358 1.000 14.978 ? 434 ILE EEE C   1 ? 
ATOM   798  O O   . ILE A 1 105 ? 58.491 11.858 -18.020 1.000 17.339 ? 434 ILE EEE O   1 ? 
ATOM   799  C CB  . ILE A 1 105 ? 60.892 10.953 -16.282 1.000 15.089 ? 434 ILE EEE CB  1 ? 
ATOM   800  C CG1 . ILE A 1 105 ? 62.272 11.283 -15.702 1.000 16.655 ? 434 ILE EEE CG1 1 ? 
ATOM   801  C CG2 . ILE A 1 105 ? 60.547 9.482  -16.132 1.000 17.020 ? 434 ILE EEE CG2 1 ? 
ATOM   802  C CD1 . ILE A 1 105 ? 62.288 11.424 -14.204 1.000 18.968 ? 434 ILE EEE CD1 1 ? 
ATOM   803  N N   . ALA A 1 106 ? 59.296 10.136 -19.236 1.000 14.168 ? 435 ALA EEE N   1 ? 
ATOM   804  C CA  . ALA A 1 106 ? 57.997 9.810  -19.857 1.000 14.032 ? 435 ALA EEE CA  1 ? 
ATOM   805  C C   . ALA A 1 106 ? 57.841 8.301  -19.970 1.000 15.522 ? 435 ALA EEE C   1 ? 
ATOM   806  O O   . ALA A 1 106 ? 58.860 7.569  -19.988 1.000 16.718 ? 435 ALA EEE O   1 ? 
ATOM   807  C CB  . ALA A 1 106 ? 57.845 10.479 -21.197 1.000 14.284 ? 435 ALA EEE CB  1 ? 
ATOM   808  N N   . TRP A 1 107 ? 56.587 7.868  -19.999 1.000 15.847 ? 436 TRP EEE N   1 ? 
ATOM   809  C CA  . TRP A 1 107 ? 56.223 6.448  -20.201 1.000 15.957 ? 436 TRP EEE CA  1 ? 
ATOM   810  C C   . TRP A 1 107 ? 54.884 6.366  -20.917 1.000 17.097 ? 436 TRP EEE C   1 ? 
ATOM   811  O O   . TRP A 1 107 ? 54.047 7.267  -20.763 1.000 14.695 ? 436 TRP EEE O   1 ? 
ATOM   812  C CB  . TRP A 1 107 ? 56.221 5.670  -18.881 1.000 16.312 ? 436 TRP EEE CB  1 ? 
ATOM   813  C CG  . TRP A 1 107 ? 55.211 6.086  -17.857 1.000 16.302 ? 436 TRP EEE CG  1 ? 
ATOM   814  C CD1 . TRP A 1 107 ? 54.023 5.478  -17.577 1.000 19.142 ? 436 TRP EEE CD1 1 ? 
ATOM   815  C CD2 . TRP A 1 107 ? 55.332 7.174  -16.927 1.000 16.546 ? 436 TRP EEE CD2 1 ? 
ATOM   816  N NE1 . TRP A 1 107 ? 53.388 6.123  -16.553 1.000 19.835 ? 436 TRP EEE NE1 1 ? 
ATOM   817  C CE2 . TRP A 1 107 ? 54.170 7.161  -16.126 1.000 17.627 ? 436 TRP EEE CE2 1 ? 
ATOM   818  C CE3 . TRP A 1 107 ? 56.302 8.155  -16.703 1.000 17.821 ? 436 TRP EEE CE3 1 ? 
ATOM   819  C CZ2 . TRP A 1 107 ? 53.959 8.100  -15.117 1.000 17.073 ? 436 TRP EEE CZ2 1 ? 
ATOM   820  C CZ3 . TRP A 1 107 ? 56.087 9.084  -15.713 1.000 16.503 ? 436 TRP EEE CZ3 1 ? 
ATOM   821  C CH2 . TRP A 1 107 ? 54.938 9.043  -14.922 1.000 17.914 ? 436 TRP EEE CH2 1 ? 
ATOM   822  N N   . ASN A 1 108 ? 54.716 5.291  -21.680 1.000 17.652 ? 437 ASN EEE N   1 ? 
ATOM   823  C CA  . ASN A 1 108 ? 53.462 4.998  -22.406 1.000 17.301 ? 437 ASN EEE CA  1 ? 
ATOM   824  C C   . ASN A 1 108 ? 52.379 4.688  -21.371 1.000 16.224 ? 437 ASN EEE C   1 ? 
ATOM   825  O O   . ASN A 1 108 ? 52.611 3.799  -20.517 1.000 17.945 ? 437 ASN EEE O   1 ? 
ATOM   826  C CB  . ASN A 1 108 ? 53.703 3.867  -23.402 1.000 18.251 ? 437 ASN EEE CB  1 ? 
ATOM   827  C CG  . ASN A 1 108 ? 52.483 3.572  -24.235 1.000 16.910 ? 437 ASN EEE CG  1 ? 
ATOM   828  O OD1 . ASN A 1 108 ? 51.456 3.169  -23.695 1.000 19.186 ? 437 ASN EEE OD1 1 ? 
ATOM   829  N ND2 . ASN A 1 108 ? 52.598 3.780  -25.541 1.000 18.508 ? 437 ASN EEE ND2 1 ? 
ATOM   830  N N   . SER A 1 109 ? 51.251 5.401  -21.422 1.000 15.379 ? 438 SER EEE N   1 ? 
ATOM   831  C CA  . SER A 1 109 ? 50.111 5.216  -20.487 1.000 15.500 ? 438 SER EEE CA  1 ? 
ATOM   832  C C   . SER A 1 109 ? 48.860 4.738  -21.242 1.000 15.638 ? 438 SER EEE C   1 ? 
ATOM   833  O O   . SER A 1 109 ? 47.748 4.952  -20.741 1.000 17.995 ? 438 SER EEE O   1 ? 
ATOM   834  C CB  . SER A 1 109 ? 49.854 6.478  -19.691 1.000 16.761 ? 438 SER EEE CB  1 ? 
ATOM   835  O OG  . SER A 1 109 ? 49.515 7.557  -20.553 1.000 17.973 ? 438 SER EEE OG  1 ? 
ATOM   836  N N   . ASN A 1 110 ? 49.037 4.077  -22.385 1.000 15.751 ? 439 ASN EEE N   1 ? 
ATOM   837  C CA  . ASN A 1 110 ? 47.926 3.545  -23.227 1.000 16.659 ? 439 ASN EEE CA  1 ? 
ATOM   838  C C   . ASN A 1 110 ? 46.951 2.715  -22.369 1.000 19.898 ? 439 ASN EEE C   1 ? 
ATOM   839  O O   . ASN A 1 110 ? 45.726 2.817  -22.587 1.000 20.163 ? 439 ASN EEE O   1 ? 
ATOM   840  C CB  . ASN A 1 110 ? 48.472 2.718  -24.391 1.000 17.339 ? 439 ASN EEE CB  1 ? 
ATOM   841  C CG  . ASN A 1 110 ? 47.495 2.551  -25.532 1.000 19.447 ? 439 ASN EEE CG  1 ? 
ATOM   842  O OD1 . ASN A 1 110 ? 46.805 3.494  -25.908 1.000 19.514 ? 439 ASN EEE OD1 1 ? 
ATOM   843  N ND2 . ASN A 1 110 ? 47.455 1.356  -26.105 1.000 23.055 ? 439 ASN EEE ND2 1 ? 
ATOM   844  N N   . ASN A 1 111 ? 47.454 1.930  -21.415 1.000 21.290 ? 440 ASN EEE N   1 ? 
ATOM   845  C CA  A ASN A 1 111 ? 46.627 0.998  -20.601 0.500 23.858 ? 440 ASN EEE CA  1 ? 
ATOM   846  C CA  B ASN A 1 111 ? 46.610 0.997  -20.621 0.500 24.144 ? 440 ASN EEE CA  1 ? 
ATOM   847  C C   . ASN A 1 111 ? 45.716 1.778  -19.641 1.000 23.829 ? 440 ASN EEE C   1 ? 
ATOM   848  O O   . ASN A 1 111 ? 44.662 1.238  -19.277 1.000 27.480 ? 440 ASN EEE O   1 ? 
ATOM   849  C CB  A ASN A 1 111 ? 47.490 -0.000 -19.821 0.500 24.456 ? 440 ASN EEE CB  1 ? 
ATOM   850  C CB  B ASN A 1 111 ? 47.457 -0.066 -19.913 0.500 25.148 ? 440 ASN EEE CB  1 ? 
ATOM   851  C CG  A ASN A 1 111 ? 48.356 0.665  -18.770 0.500 26.147 ? 440 ASN EEE CG  1 ? 
ATOM   852  C CG  B ASN A 1 111 ? 48.026 -1.101 -20.863 0.500 27.831 ? 440 ASN EEE CG  1 ? 
ATOM   853  O OD1 A ASN A 1 111 ? 49.032 1.651  -19.052 0.500 28.792 ? 440 ASN EEE OD1 1 ? 
ATOM   854  O OD1 B ASN A 1 111 ? 47.613 -1.194 -22.019 0.500 29.380 ? 440 ASN EEE OD1 1 ? 
ATOM   855  N ND2 A ASN A 1 111 ? 48.346 0.134  -17.558 0.500 29.788 ? 440 ASN EEE ND2 1 ? 
ATOM   856  N ND2 B ASN A 1 111 ? 48.960 -1.902 -20.378 0.500 34.334 ? 440 ASN EEE ND2 1 ? 
ATOM   857  N N   . LEU A 1 112 ? 46.103 2.994  -19.234 1.000 20.771 ? 441 LEU EEE N   1 ? 
ATOM   858  C CA  . LEU A 1 112 ? 45.314 3.812  -18.267 1.000 23.091 ? 441 LEU EEE CA  1 ? 
ATOM   859  C C   . LEU A 1 112 ? 44.524 4.898  -18.998 1.000 21.340 ? 441 LEU EEE C   1 ? 
ATOM   860  O O   . LEU A 1 112 ? 43.390 5.200  -18.580 1.000 24.027 ? 441 LEU EEE O   1 ? 
ATOM   861  C CB  . LEU A 1 112 ? 46.239 4.467  -17.240 1.000 26.922 ? 441 LEU EEE CB  1 ? 
ATOM   862  C CG  . LEU A 1 112 ? 47.087 3.529  -16.383 1.000 32.439 ? 441 LEU EEE CG  1 ? 
ATOM   863  C CD1 . LEU A 1 112 ? 48.000 4.340  -15.475 1.000 34.064 ? 441 LEU EEE CD1 1 ? 
ATOM   864  C CD2 . LEU A 1 112 ? 46.209 2.585  -15.576 1.000 35.935 ? 441 LEU EEE CD2 1 ? 
ATOM   865  N N   . ASP A 1 113 ? 45.122 5.508  -20.021 1.000 17.845 ? 442 ASP EEE N   1 ? 
ATOM   866  C CA  . ASP A 1 113 ? 44.655 6.821  -20.522 1.000 16.964 ? 442 ASP EEE CA  1 ? 
ATOM   867  C C   . ASP A 1 113 ? 43.938 6.692  -21.865 1.000 19.072 ? 442 ASP EEE C   1 ? 
ATOM   868  O O   . ASP A 1 113 ? 43.391 7.701  -22.307 1.000 19.822 ? 442 ASP EEE O   1 ? 
ATOM   869  C CB  . ASP A 1 113 ? 45.816 7.808  -20.590 1.000 17.471 ? 442 ASP EEE CB  1 ? 
ATOM   870  C CG  . ASP A 1 113 ? 46.271 8.293  -19.227 1.000 16.584 ? 442 ASP EEE CG  1 ? 
ATOM   871  O OD1 . ASP A 1 113 ? 45.399 8.490  -18.348 1.000 17.015 ? 442 ASP EEE OD1 1 ? 
ATOM   872  O OD2 . ASP A 1 113 ? 47.489 8.523  -19.080 1.000 17.652 ? 442 ASP EEE OD2 1 ? 
ATOM   873  N N   . SER A 1 114 ? 43.988 5.530  -22.517 1.000 17.476 ? 443 SER EEE N   1 ? 
ATOM   874  C CA  . SER A 1 114 ? 43.202 5.262  -23.743 1.000 19.287 ? 443 SER EEE CA  1 ? 
ATOM   875  C C   . SER A 1 114 ? 41.970 4.462  -23.337 1.000 19.383 ? 443 SER EEE C   1 ? 
ATOM   876  O O   . SER A 1 114 ? 42.047 3.710  -22.359 1.000 20.491 ? 443 SER EEE O   1 ? 
ATOM   877  C CB  . SER A 1 114 ? 43.983 4.536  -24.792 1.000 18.978 ? 443 SER EEE CB  1 ? 
ATOM   878  O OG  . SER A 1 114 ? 45.094 5.296  -25.236 1.000 22.438 ? 443 SER EEE OG  1 ? 
ATOM   879  N N   . LYS A 1 115 ? 40.876 4.642  -24.060 1.000 20.151 ? 444 LYS EEE N   1 ? 
ATOM   880  C CA  . LYS A 1 115 ? 39.640 3.857  -23.863 1.000 22.113 ? 444 LYS EEE CA  1 ? 
ATOM   881  C C   . LYS A 1 115 ? 39.145 3.423  -25.235 1.000 21.299 ? 444 LYS EEE C   1 ? 
ATOM   882  O O   . LYS A 1 115 ? 39.296 4.184  -26.206 1.000 21.008 ? 444 LYS EEE O   1 ? 
ATOM   883  C CB  . LYS A 1 115 ? 38.602 4.690  -23.108 1.000 26.288 ? 444 LYS EEE CB  1 ? 
ATOM   884  C CG  . LYS A 1 115 ? 37.226 4.054  -22.977 1.000 41.534 ? 444 LYS EEE CG  1 ? 
ATOM   885  C CD  . LYS A 1 115 ? 36.228 4.897  -22.217 1.000 48.745 ? 444 LYS EEE CD  1 ? 
ATOM   886  C CE  . LYS A 1 115 ? 34.946 4.150  -21.922 1.000 55.016 ? 444 LYS EEE CE  1 ? 
ATOM   887  N NZ  . LYS A 1 115 ? 34.082 4.904  -20.986 1.000 64.597 ? 444 LYS EEE NZ  1 ? 
ATOM   888  N N   . VAL A 1 116 ? 38.580 2.225  -25.311 1.000 22.783 ? 445 VAL EEE N   1 ? 
ATOM   889  C CA  A VAL A 1 116 ? 37.832 1.780  -26.519 0.500 24.644 ? 445 VAL EEE CA  1 ? 
ATOM   890  C CA  B VAL A 1 116 ? 37.835 1.782  -26.522 0.500 22.822 ? 445 VAL EEE CA  1 ? 
ATOM   891  C C   . VAL A 1 116 ? 36.752 2.838  -26.779 1.000 21.969 ? 445 VAL EEE C   1 ? 
ATOM   892  O O   . VAL A 1 116 ? 36.051 3.193  -25.823 1.000 25.604 ? 445 VAL EEE O   1 ? 
ATOM   893  C CB  A VAL A 1 116 ? 37.245 0.365  -26.340 0.500 26.393 ? 445 VAL EEE CB  1 ? 
ATOM   894  C CB  B VAL A 1 116 ? 37.247 0.366  -26.354 0.500 22.099 ? 445 VAL EEE CB  1 ? 
ATOM   895  C CG1 A VAL A 1 116 ? 38.333 -0.666 -26.071 0.500 28.109 ? 445 VAL EEE CG1 1 ? 
ATOM   896  C CG1 B VAL A 1 116 ? 36.456 -0.056 -27.584 0.500 21.498 ? 445 VAL EEE CG1 1 ? 
ATOM   897  C CG2 A VAL A 1 116 ? 36.179 0.316  -25.257 0.500 29.331 ? 445 VAL EEE CG2 1 ? 
ATOM   898  C CG2 B VAL A 1 116 ? 38.327 -0.659 -26.036 0.500 23.344 ? 445 VAL EEE CG2 1 ? 
ATOM   899  N N   . GLY A 1 117 ? 36.674 3.346  -28.007 1.000 23.650 ? 446 GLY EEE N   1 ? 
ATOM   900  C CA  . GLY A 1 117 ? 35.734 4.420  -28.378 1.000 26.175 ? 446 GLY EEE CA  1 ? 
ATOM   901  C C   . GLY A 1 117 ? 36.340 5.794  -28.156 1.000 28.354 ? 446 GLY EEE C   1 ? 
ATOM   902  O O   . GLY A 1 117 ? 35.727 6.797  -28.588 1.000 29.063 ? 446 GLY EEE O   1 ? 
ATOM   903  N N   . GLY A 1 118 ? 37.498 5.849  -27.497 1.000 21.924 ? 447 GLY EEE N   1 ? 
ATOM   904  C CA  . GLY A 1 118 ? 38.263 7.096  -27.337 1.000 21.672 ? 447 GLY EEE CA  1 ? 
ATOM   905  C C   . GLY A 1 118 ? 38.114 7.681  -25.951 1.000 20.645 ? 447 GLY EEE C   1 ? 
ATOM   906  O O   . GLY A 1 118 ? 36.982 7.757  -25.431 1.000 22.061 ? 447 GLY EEE O   1 ? 
ATOM   907  N N   . ASN A 1 119 ? 39.243 8.079  -25.363 1.000 17.698 ? 448 ASN EEE N   1 ? 
ATOM   908  C CA  . ASN A 1 119 ? 39.272 9.017  -24.221 1.000 16.756 ? 448 ASN EEE CA  1 ? 
ATOM   909  C C   . ASN A 1 119 ? 39.640 10.391 -24.774 1.000 16.517 ? 448 ASN EEE C   1 ? 
ATOM   910  O O   . ASN A 1 119 ? 40.750 10.507 -25.318 1.000 15.198 ? 448 ASN EEE O   1 ? 
ATOM   911  C CB  . ASN A 1 119 ? 40.263 8.590  -23.143 1.000 16.381 ? 448 ASN EEE CB  1 ? 
ATOM   912  C CG  . ASN A 1 119 ? 40.382 9.613  -22.035 1.000 17.583 ? 448 ASN EEE CG  1 ? 
ATOM   913  O OD1 . ASN A 1 119 ? 39.484 10.419 -21.822 1.000 17.982 ? 448 ASN EEE OD1 1 ? 
ATOM   914  N ND2 . ASN A 1 119 ? 41.491 9.585  -21.316 1.000 18.100 ? 448 ASN EEE ND2 1 ? 
ATOM   915  N N   . TYR A 1 120 ? 38.745 11.376 -24.625 1.000 16.459 ? 449 TYR EEE N   1 ? 
ATOM   916  C CA  . TYR A 1 120 ? 38.908 12.747 -25.169 1.000 15.283 ? 449 TYR EEE CA  1 ? 
ATOM   917  C C   . TYR A 1 120 ? 39.073 13.776 -24.048 1.000 14.612 ? 449 TYR EEE C   1 ? 
ATOM   918  O O   . TYR A 1 120 ? 39.046 14.975 -24.327 1.000 16.172 ? 449 TYR EEE O   1 ? 
ATOM   919  C CB  . TYR A 1 120 ? 37.703 13.100 -26.036 1.000 15.019 ? 449 TYR EEE CB  1 ? 
ATOM   920  C CG  . TYR A 1 120 ? 37.511 12.184 -27.208 1.000 16.874 ? 449 TYR EEE CG  1 ? 
ATOM   921  C CD1 . TYR A 1 120 ? 38.160 12.415 -28.408 1.000 18.043 ? 449 TYR EEE CD1 1 ? 
ATOM   922  C CD2 . TYR A 1 120 ? 36.664 11.092 -27.105 1.000 20.992 ? 449 TYR EEE CD2 1 ? 
ATOM   923  C CE1 . TYR A 1 120 ? 37.965 11.581 -29.496 1.000 21.727 ? 449 TYR EEE CE1 1 ? 
ATOM   924  C CE2 . TYR A 1 120 ? 36.469 10.245 -28.182 1.000 22.055 ? 449 TYR EEE CE2 1 ? 
ATOM   925  C CZ  . TYR A 1 120 ? 37.120 10.494 -29.375 1.000 24.017 ? 449 TYR EEE CZ  1 ? 
ATOM   926  O OH  . TYR A 1 120 ? 36.925 9.663  -30.438 1.000 37.113 ? 449 TYR EEE OH  1 ? 
ATOM   927  N N   . ASN A 1 121 ? 39.292 13.330 -22.816 1.000 14.711 ? 450 ASN EEE N   1 ? 
ATOM   928  C CA  . ASN A 1 121 ? 39.322 14.234 -21.643 1.000 15.879 ? 450 ASN EEE CA  1 ? 
ATOM   929  C C   . ASN A 1 121 ? 40.651 14.991 -21.529 1.000 15.475 ? 450 ASN EEE C   1 ? 
ATOM   930  O O   . ASN A 1 121 ? 40.661 16.029 -20.855 1.000 18.453 ? 450 ASN EEE O   1 ? 
ATOM   931  C CB  . ASN A 1 121 ? 38.975 13.459 -20.378 1.000 17.950 ? 450 ASN EEE CB  1 ? 
ATOM   932  C CG  . ASN A 1 121 ? 37.504 13.100 -20.354 1.000 21.555 ? 450 ASN EEE CG  1 ? 
ATOM   933  O OD1 . ASN A 1 121 ? 36.654 13.930 -20.690 1.000 25.975 ? 450 ASN EEE OD1 1 ? 
ATOM   934  N ND2 . ASN A 1 121 ? 37.201 11.867 -19.992 1.000 27.778 ? 450 ASN EEE ND2 1 ? 
ATOM   935  N N   . TYR A 1 122 ? 41.727 14.509 -22.145 1.000 13.986 ? 451 TYR EEE N   1 ? 
ATOM   936  C CA  . TYR A 1 122 ? 43.016 15.233 -22.171 1.000 13.843 ? 451 TYR EEE CA  1 ? 
ATOM   937  C C   . TYR A 1 122 ? 42.997 16.236 -23.325 1.000 13.400 ? 451 TYR EEE C   1 ? 
ATOM   938  O O   . TYR A 1 122 ? 42.751 15.821 -24.469 1.000 14.581 ? 451 TYR EEE O   1 ? 
ATOM   939  C CB  . TYR A 1 122 ? 44.186 14.274 -22.326 1.000 13.783 ? 451 TYR EEE CB  1 ? 
ATOM   940  C CG  . TYR A 1 122 ? 44.454 13.422 -21.113 1.000 14.763 ? 451 TYR EEE CG  1 ? 
ATOM   941  C CD1 . TYR A 1 122 ? 45.047 13.966 -19.984 1.000 15.994 ? 451 TYR EEE CD1 1 ? 
ATOM   942  C CD2 . TYR A 1 122 ? 44.122 12.083 -21.100 1.000 15.753 ? 451 TYR EEE CD2 1 ? 
ATOM   943  C CE1 . TYR A 1 122 ? 45.308 13.189 -18.871 1.000 15.978 ? 451 TYR EEE CE1 1 ? 
ATOM   944  C CE2 . TYR A 1 122 ? 44.381 11.291 -19.995 1.000 15.736 ? 451 TYR EEE CE2 1 ? 
ATOM   945  C CZ  . TYR A 1 122 ? 44.980 11.845 -18.881 1.000 16.304 ? 451 TYR EEE CZ  1 ? 
ATOM   946  O OH  . TYR A 1 122 ? 45.236 11.084 -17.774 1.000 17.674 ? 451 TYR EEE OH  1 ? 
ATOM   947  N N   . LEU A 1 123 ? 43.227 17.508 -23.010 1.000 13.737 ? 452 LEU EEE N   1 ? 
ATOM   948  C CA  . LEU A 1 123 ? 43.188 18.616 -23.996 1.000 13.472 ? 452 LEU EEE CA  1 ? 
ATOM   949  C C   . LEU A 1 123 ? 44.578 19.211 -24.185 1.000 13.567 ? 452 LEU EEE C   1 ? 
ATOM   950  O O   . LEU A 1 123 ? 45.432 19.091 -23.294 1.000 14.162 ? 452 LEU EEE O   1 ? 
ATOM   951  C CB  . LEU A 1 123 ? 42.256 19.725 -23.519 1.000 14.380 ? 452 LEU EEE CB  1 ? 
ATOM   952  C CG  . LEU A 1 123 ? 40.870 19.317 -23.042 1.000 16.315 ? 452 LEU EEE CG  1 ? 
ATOM   953  C CD1 . LEU A 1 123 ? 40.067 20.557 -22.705 1.000 17.009 ? 452 LEU EEE CD1 1 ? 
ATOM   954  C CD2 . LEU A 1 123 ? 40.154 18.465 -24.073 1.000 17.463 ? 452 LEU EEE CD2 1 ? 
ATOM   955  N N   . TYR A 1 124 ? 44.749 19.910 -25.296 1.000 13.291 ? 453 TYR EEE N   1 ? 
ATOM   956  C CA  . TYR A 1 124 ? 45.919 20.776 -25.561 1.000 13.744 ? 453 TYR EEE CA  1 ? 
ATOM   957  C C   . TYR A 1 124 ? 45.393 22.098 -26.100 1.000 13.297 ? 453 TYR EEE C   1 ? 
ATOM   958  O O   . TYR A 1 124 ? 44.272 22.147 -26.662 1.000 14.522 ? 453 TYR EEE O   1 ? 
ATOM   959  C CB  . TYR A 1 124 ? 46.904 20.118 -26.527 1.000 14.031 ? 453 TYR EEE CB  1 ? 
ATOM   960  C CG  . TYR A 1 124 ? 46.298 19.732 -27.850 1.000 13.223 ? 453 TYR EEE CG  1 ? 
ATOM   961  C CD1 . TYR A 1 124 ? 45.689 18.499 -28.027 1.000 13.364 ? 453 TYR EEE CD1 1 ? 
ATOM   962  C CD2 . TYR A 1 124 ? 46.320 20.599 -28.932 1.000 14.526 ? 453 TYR EEE CD2 1 ? 
ATOM   963  C CE1 . TYR A 1 124 ? 45.127 18.141 -29.242 1.000 14.270 ? 453 TYR EEE CE1 1 ? 
ATOM   964  C CE2 . TYR A 1 124 ? 45.751 20.262 -30.146 1.000 15.191 ? 453 TYR EEE CE2 1 ? 
ATOM   965  C CZ  . TYR A 1 124 ? 45.144 19.030 -30.304 1.000 14.467 ? 453 TYR EEE CZ  1 ? 
ATOM   966  O OH  . TYR A 1 124 ? 44.586 18.665 -31.502 1.000 16.416 ? 453 TYR EEE OH  1 ? 
ATOM   967  N N   . ARG A 1 125 ? 46.188 23.145 -25.924 1.000 13.045 ? 454 ARG EEE N   1 ? 
ATOM   968  C CA  . ARG A 1 125 ? 45.915 24.479 -26.503 1.000 13.307 ? 454 ARG EEE CA  1 ? 
ATOM   969  C C   . ARG A 1 125 ? 46.426 24.476 -27.940 1.000 13.311 ? 454 ARG EEE C   1 ? 
ATOM   970  O O   . ARG A 1 125 ? 47.621 24.196 -28.150 1.000 14.330 ? 454 ARG EEE O   1 ? 
ATOM   971  C CB  . ARG A 1 125 ? 46.549 25.586 -25.659 1.000 13.739 ? 454 ARG EEE CB  1 ? 
ATOM   972  C CG  . ARG A 1 125 ? 46.177 26.987 -26.131 1.000 13.668 ? 454 ARG EEE CG  1 ? 
ATOM   973  C CD  . ARG A 1 125 ? 46.692 28.093 -25.224 1.000 13.827 ? 454 ARG EEE CD  1 ? 
ATOM   974  N NE  . ARG A 1 125 ? 46.174 27.892 -23.889 1.000 14.509 ? 454 ARG EEE NE  1 ? 
ATOM   975  C CZ  . ARG A 1 125 ? 44.958 28.222 -23.461 1.000 14.616 ? 454 ARG EEE CZ  1 ? 
ATOM   976  N NH1 . ARG A 1 125 ? 44.099 28.865 -24.239 1.000 14.700 ? 454 ARG EEE NH1 1 ? 
ATOM   977  N NH2 . ARG A 1 125 ? 44.595 27.890 -22.242 1.000 15.472 ? 454 ARG EEE NH2 1 ? 
ATOM   978  N N   . LEU A 1 126 ? 45.536 24.787 -28.881 1.000 13.592 ? 455 LEU EEE N   1 ? 
ATOM   979  C CA  . LEU A 1 126 ? 45.817 24.757 -30.335 1.000 15.178 ? 455 LEU EEE CA  1 ? 
ATOM   980  C C   . LEU A 1 126 ? 46.152 26.167 -30.828 1.000 14.677 ? 455 LEU EEE C   1 ? 
ATOM   981  O O   . LEU A 1 126 ? 46.903 26.276 -31.794 1.000 16.146 ? 455 LEU EEE O   1 ? 
ATOM   982  C CB  . LEU A 1 126 ? 44.598 24.179 -31.056 1.000 16.611 ? 455 LEU EEE CB  1 ? 
ATOM   983  C CG  . LEU A 1 126 ? 44.695 24.100 -32.579 1.000 18.445 ? 455 LEU EEE CG  1 ? 
ATOM   984  C CD1 . LEU A 1 126 ? 45.859 23.224 -33.013 1.000 20.871 ? 455 LEU EEE CD1 1 ? 
ATOM   985  C CD2 . LEU A 1 126 ? 43.381 23.585 -33.148 1.000 19.874 ? 455 LEU EEE CD2 1 ? 
ATOM   986  N N   . PHE A 1 127 ? 45.565 27.193 -30.208 1.000 15.525 ? 456 PHE EEE N   1 ? 
ATOM   987  C CA  . PHE A 1 127 ? 45.684 28.602 -30.656 1.000 15.551 ? 456 PHE EEE CA  1 ? 
ATOM   988  C C   . PHE A 1 127 ? 46.109 29.483 -29.494 1.000 16.011 ? 456 PHE EEE C   1 ? 
ATOM   989  O O   . PHE A 1 127 ? 45.580 29.327 -28.380 1.000 15.427 ? 456 PHE EEE O   1 ? 
ATOM   990  C CB  . PHE A 1 127 ? 44.346 29.107 -31.195 1.000 16.241 ? 456 PHE EEE CB  1 ? 
ATOM   991  C CG  . PHE A 1 127 ? 43.890 28.448 -32.467 1.000 16.422 ? 456 PHE EEE CG  1 ? 
ATOM   992  C CD1 . PHE A 1 127 ? 44.508 28.742 -33.670 1.000 17.805 ? 456 PHE EEE CD1 1 ? 
ATOM   993  C CD2 . PHE A 1 127 ? 42.841 27.543 -32.465 1.000 19.135 ? 456 PHE EEE CD2 1 ? 
ATOM   994  C CE1 . PHE A 1 127 ? 44.089 28.145 -34.846 1.000 17.926 ? 456 PHE EEE CE1 1 ? 
ATOM   995  C CE2 . PHE A 1 127 ? 42.421 26.947 -33.647 1.000 19.082 ? 456 PHE EEE CE2 1 ? 
ATOM   996  C CZ  . PHE A 1 127 ? 43.054 27.243 -34.832 1.000 18.936 ? 456 PHE EEE CZ  1 ? 
ATOM   997  N N   . ARG A 1 128 ? 47.019 30.414 -29.767 1.000 17.047 ? 457 ARG EEE N   1 ? 
ATOM   998  C CA  . ARG A 1 128 ? 47.471 31.410 -28.765 1.000 17.259 ? 457 ARG EEE CA  1 ? 
ATOM   999  C C   . ARG A 1 128 ? 48.125 32.578 -29.499 1.000 17.017 ? 457 ARG EEE C   1 ? 
ATOM   1000 O O   . ARG A 1 128 ? 48.722 32.329 -30.560 1.000 19.494 ? 457 ARG EEE O   1 ? 
ATOM   1001 C CB  . ARG A 1 128 ? 48.467 30.794 -27.781 1.000 17.553 ? 457 ARG EEE CB  1 ? 
ATOM   1002 C CG  . ARG A 1 128 ? 48.520 31.516 -26.446 1.000 17.499 ? 457 ARG EEE CG  1 ? 
ATOM   1003 C CD  . ARG A 1 128 ? 49.428 30.811 -25.451 1.000 18.353 ? 457 ARG EEE CD  1 ? 
ATOM   1004 N NE  . ARG A 1 128 ? 49.348 31.460 -24.157 1.000 18.725 ? 457 ARG EEE NE  1 ? 
ATOM   1005 C CZ  . ARG A 1 128 ? 50.149 32.436 -23.732 1.000 20.176 ? 457 ARG EEE CZ  1 ? 
ATOM   1006 N NH1 . ARG A 1 128 ? 51.159 32.857 -24.478 1.000 19.738 ? 457 ARG EEE NH1 1 ? 
ATOM   1007 N NH2 . ARG A 1 128 ? 49.965 32.949 -22.529 1.000 22.367 ? 457 ARG EEE NH2 1 ? 
ATOM   1008 N N   . LYS A 1 129 ? 47.994 33.781 -28.943 1.000 19.813 ? 458 LYS EEE N   1 ? 
ATOM   1009 C CA  . LYS A 1 129 ? 48.476 35.041 -29.571 1.000 22.185 ? 458 LYS EEE CA  1 ? 
ATOM   1010 C C   . LYS A 1 129 ? 50.007 35.073 -29.584 1.000 22.524 ? 458 LYS EEE C   1 ? 
ATOM   1011 O O   . LYS A 1 129 ? 50.583 35.785 -30.436 1.000 24.192 ? 458 LYS EEE O   1 ? 
ATOM   1012 C CB  . LYS A 1 129 ? 47.889 36.252 -28.840 1.000 24.588 ? 458 LYS EEE CB  1 ? 
ATOM   1013 C CG  . LYS A 1 129 ? 46.398 36.463 -29.074 1.000 29.314 ? 458 LYS EEE CG  1 ? 
ATOM   1014 C CD  . LYS A 1 129 ? 45.901 37.855 -28.726 1.000 39.594 ? 458 LYS EEE CD  1 ? 
ATOM   1015 C CE  . LYS A 1 129 ? 46.244 38.291 -27.318 1.000 43.119 ? 458 LYS EEE CE  1 ? 
ATOM   1016 N NZ  . LYS A 1 129 ? 45.616 39.594 -26.991 1.000 48.787 ? 458 LYS EEE NZ  1 ? 
ATOM   1017 N N   . SER A 1 130 ? 50.657 34.361 -28.664 1.000 20.238 ? 459 SER EEE N   1 ? 
ATOM   1018 C CA  . SER A 1 130 ? 52.137 34.323 -28.572 1.000 20.249 ? 459 SER EEE CA  1 ? 
ATOM   1019 C C   . SER A 1 130 ? 52.572 33.043 -27.861 1.000 18.492 ? 459 SER EEE C   1 ? 
ATOM   1020 O O   . SER A 1 130 ? 51.719 32.392 -27.232 1.000 18.035 ? 459 SER EEE O   1 ? 
ATOM   1021 C CB  . SER A 1 130 ? 52.661 35.549 -27.871 1.000 19.401 ? 459 SER EEE CB  1 ? 
ATOM   1022 O OG  . SER A 1 130 ? 52.219 35.590 -26.530 1.000 24.042 ? 459 SER EEE OG  1 ? 
ATOM   1023 N N   . ASN A 1 131 ? 53.861 32.733 -27.936 1.000 17.769 ? 460 ASN EEE N   1 ? 
ATOM   1024 C CA  . ASN A 1 131 ? 54.454 31.549 -27.273 1.000 16.633 ? 460 ASN EEE CA  1 ? 
ATOM   1025 C C   . ASN A 1 131 ? 54.476 31.775 -25.760 1.000 18.337 ? 460 ASN EEE C   1 ? 
ATOM   1026 O O   . ASN A 1 131 ? 54.688 32.914 -25.309 1.000 18.475 ? 460 ASN EEE O   1 ? 
ATOM   1027 C CB  . ASN A 1 131 ? 55.845 31.236 -27.813 1.000 17.478 ? 460 ASN EEE CB  1 ? 
ATOM   1028 C CG  . ASN A 1 131 ? 55.824 30.697 -29.226 1.000 19.364 ? 460 ASN EEE CG  1 ? 
ATOM   1029 O OD1 . ASN A 1 131 ? 54.763 30.596 -29.842 1.000 22.391 ? 460 ASN EEE OD1 1 ? 
ATOM   1030 N ND2 . ASN A 1 131 ? 56.987 30.328 -29.732 1.000 23.694 ? 460 ASN EEE ND2 1 ? 
ATOM   1031 N N   . LEU A 1 132 ? 54.264 30.703 -25.001 1.000 17.037 ? 461 LEU EEE N   1 ? 
ATOM   1032 C CA  . LEU A 1 132 ? 54.483 30.703 -23.537 1.000 16.671 ? 461 LEU EEE CA  1 ? 
ATOM   1033 C C   . LEU A 1 132 ? 55.937 31.070 -23.258 1.000 16.839 ? 461 LEU EEE C   1 ? 
ATOM   1034 O O   . LEU A 1 132 ? 56.834 30.620 -24.000 1.000 17.819 ? 461 LEU EEE O   1 ? 
ATOM   1035 C CB  . LEU A 1 132 ? 54.194 29.315 -22.968 1.000 15.759 ? 461 LEU EEE CB  1 ? 
ATOM   1036 C CG  . LEU A 1 132 ? 52.734 28.885 -22.933 1.000 17.483 ? 461 LEU EEE CG  1 ? 
ATOM   1037 C CD1 . LEU A 1 132 ? 52.630 27.441 -22.469 1.000 18.805 ? 461 LEU EEE CD1 1 ? 
ATOM   1038 C CD2 . LEU A 1 132 ? 51.906 29.793 -22.036 1.000 17.756 ? 461 LEU EEE CD2 1 ? 
ATOM   1039 N N   . LYS A 1 133 ? 56.149 31.818 -22.179 1.000 18.531 ? 462 LYS EEE N   1 ? 
ATOM   1040 C CA  . LYS A 1 133 ? 57.481 31.931 -21.544 1.000 19.488 ? 462 LYS EEE CA  1 ? 
ATOM   1041 C C   . LYS A 1 133 ? 57.758 30.622 -20.808 1.000 17.043 ? 462 LYS EEE C   1 ? 
ATOM   1042 O O   . LYS A 1 133 ? 56.833 29.870 -20.474 1.000 16.090 ? 462 LYS EEE O   1 ? 
ATOM   1043 C CB  . LYS A 1 133 ? 57.510 33.130 -20.598 1.000 25.316 ? 462 LYS EEE CB  1 ? 
ATOM   1044 C CG  . LYS A 1 133 ? 57.325 34.480 -21.276 1.000 33.776 ? 462 LYS EEE CG  1 ? 
ATOM   1045 C CD  . LYS A 1 133 ? 57.470 35.651 -20.323 1.000 48.677 ? 462 LYS EEE CD  1 ? 
ATOM   1046 C CE  . LYS A 1 133 ? 58.735 35.596 -19.488 1.000 62.558 ? 462 LYS EEE CE  1 ? 
ATOM   1047 N NZ  . LYS A 1 133 ? 59.084 36.918 -18.911 1.000 68.388 ? 462 LYS EEE NZ  1 ? 
ATOM   1048 N N   . PRO A 1 134 ? 59.038 30.295 -20.540 1.000 18.182 ? 463 PRO EEE N   1 ? 
ATOM   1049 C CA  . PRO A 1 134 ? 59.358 29.104 -19.760 1.000 17.558 ? 463 PRO EEE CA  1 ? 
ATOM   1050 C C   . PRO A 1 134 ? 58.571 29.016 -18.444 1.000 18.534 ? 463 PRO EEE C   1 ? 
ATOM   1051 O O   . PRO A 1 134 ? 58.479 29.992 -17.705 1.000 19.514 ? 463 PRO EEE O   1 ? 
ATOM   1052 C CB  . PRO A 1 134 ? 60.870 29.236 -19.531 1.000 18.408 ? 463 PRO EEE CB  1 ? 
ATOM   1053 C CG  . PRO A 1 134 ? 61.342 30.000 -20.747 1.000 20.397 ? 463 PRO EEE CG  1 ? 
ATOM   1054 C CD  . PRO A 1 134 ? 60.241 31.012 -20.984 1.000 20.579 ? 463 PRO EEE CD  1 ? 
ATOM   1055 N N   . PHE A 1 135 ? 57.983 27.844 -18.203 1.000 16.219 ? 464 PHE EEE N   1 ? 
ATOM   1056 C CA  . PHE A 1 135 ? 57.204 27.482 -16.993 1.000 16.564 ? 464 PHE EEE CA  1 ? 
ATOM   1057 C C   . PHE A 1 135 ? 55.965 28.369 -16.826 1.000 17.042 ? 464 PHE EEE C   1 ? 
ATOM   1058 O O   . PHE A 1 135 ? 55.365 28.384 -15.726 1.000 17.470 ? 464 PHE EEE O   1 ? 
ATOM   1059 C CB  . PHE A 1 135 ? 58.099 27.534 -15.755 1.000 19.631 ? 464 PHE EEE CB  1 ? 
ATOM   1060 C CG  . PHE A 1 135 ? 59.236 26.548 -15.757 1.000 18.221 ? 464 PHE EEE CG  1 ? 
ATOM   1061 C CD1 . PHE A 1 135 ? 59.004 25.195 -15.947 1.000 17.532 ? 464 PHE EEE CD1 1 ? 
ATOM   1062 C CD2 . PHE A 1 135 ? 60.533 26.967 -15.511 1.000 20.290 ? 464 PHE EEE CD2 1 ? 
ATOM   1063 C CE1 . PHE A 1 135 ? 60.052 24.286 -15.927 1.000 19.260 ? 464 PHE EEE CE1 1 ? 
ATOM   1064 C CE2 . PHE A 1 135 ? 61.575 26.055 -15.479 1.000 20.444 ? 464 PHE EEE CE2 1 ? 
ATOM   1065 C CZ  . PHE A 1 135 ? 61.333 24.718 -15.686 1.000 19.246 ? 464 PHE EEE CZ  1 ? 
ATOM   1066 N N   . GLU A 1 136 ? 55.530 29.044 -17.895 1.000 16.107 ? 465 GLU EEE N   1 ? 
ATOM   1067 C CA  . GLU A 1 136 ? 54.216 29.727 -17.909 1.000 18.243 ? 465 GLU EEE CA  1 ? 
ATOM   1068 C C   . GLU A 1 136 ? 53.109 28.676 -18.059 1.000 17.237 ? 465 GLU EEE C   1 ? 
ATOM   1069 O O   . GLU A 1 136 ? 53.324 27.649 -18.717 1.000 17.424 ? 465 GLU EEE O   1 ? 
ATOM   1070 C CB  . GLU A 1 136 ? 54.156 30.758 -19.034 1.000 20.197 ? 465 GLU EEE CB  1 ? 
ATOM   1071 C CG  . GLU A 1 136 ? 52.967 31.689 -18.932 1.000 22.360 ? 465 GLU EEE CG  1 ? 
ATOM   1072 C CD  . GLU A 1 136 ? 52.940 32.795 -19.972 1.000 23.430 ? 465 GLU EEE CD  1 ? 
ATOM   1073 O OE1 . GLU A 1 136 ? 53.856 32.847 -20.823 1.000 21.285 ? 465 GLU EEE OE1 1 ? 
ATOM   1074 O OE2 . GLU A 1 136 ? 51.992 33.603 -19.929 1.000 30.772 ? 465 GLU EEE OE2 1 ? 
ATOM   1075 N N   . ARG A 1 137 ? 51.956 28.945 -17.457 1.000 18.338 ? 466 ARG EEE N   1 ? 
ATOM   1076 C CA  . ARG A 1 137 ? 50.755 28.085 -17.539 1.000 17.093 ? 466 ARG EEE CA  1 ? 
ATOM   1077 C C   . ARG A 1 137 ? 49.601 28.978 -17.975 1.000 18.302 ? 466 ARG EEE C   1 ? 
ATOM   1078 O O   . ARG A 1 137 ? 49.419 30.045 -17.369 1.000 20.286 ? 466 ARG EEE O   1 ? 
ATOM   1079 C CB  . ARG A 1 137 ? 50.502 27.418 -16.184 1.000 17.988 ? 466 ARG EEE CB  1 ? 
ATOM   1080 C CG  . ARG A 1 137 ? 49.363 26.408 -16.155 1.000 19.760 ? 466 ARG EEE CG  1 ? 
ATOM   1081 C CD  . ARG A 1 137 ? 49.505 25.608 -14.860 1.000 23.854 ? 466 ARG EEE CD  1 ? 
ATOM   1082 N NE  . ARG A 1 137 ? 48.459 24.656 -14.543 1.000 32.717 ? 466 ARG EEE NE  1 ? 
ATOM   1083 C CZ  . ARG A 1 137 ? 47.337 24.925 -13.876 1.000 31.621 ? 466 ARG EEE CZ  1 ? 
ATOM   1084 N NH1 . ARG A 1 137 ? 47.065 26.156 -13.472 1.000 31.869 ? 466 ARG EEE NH1 1 ? 
ATOM   1085 N NH2 . ARG A 1 137 ? 46.474 23.954 -13.632 1.000 31.291 ? 466 ARG EEE NH2 1 ? 
ATOM   1086 N N   . ASP A 1 138 ? 48.896 28.590 -19.030 1.000 16.242 ? 467 ASP EEE N   1 ? 
ATOM   1087 C CA  . ASP A 1 138 ? 47.710 29.323 -19.535 1.000 16.867 ? 467 ASP EEE CA  1 ? 
ATOM   1088 C C   . ASP A 1 138 ? 46.515 28.374 -19.479 1.000 15.910 ? 467 ASP EEE C   1 ? 
ATOM   1089 O O   . ASP A 1 138 ? 46.528 27.387 -20.240 1.000 15.692 ? 467 ASP EEE O   1 ? 
ATOM   1090 C CB  . ASP A 1 138 ? 47.984 29.850 -20.941 1.000 16.388 ? 467 ASP EEE CB  1 ? 
ATOM   1091 C CG  . ASP A 1 138 ? 46.866 30.704 -21.514 1.000 18.608 ? 467 ASP EEE CG  1 ? 
ATOM   1092 O OD1 . ASP A 1 138 ? 45.813 30.820 -20.853 1.000 20.008 ? 467 ASP EEE OD1 1 ? 
ATOM   1093 O OD2 . ASP A 1 138 ? 47.072 31.252 -22.622 1.000 20.719 ? 467 ASP EEE OD2 1 ? 
ATOM   1094 N N   . ILE A 1 139 ? 45.545 28.632 -18.596 1.000 15.813 ? 468 ILE EEE N   1 ? 
ATOM   1095 C CA  . ILE A 1 139 ? 44.309 27.800 -18.494 1.000 15.985 ? 468 ILE EEE CA  1 ? 
ATOM   1096 C C   . ILE A 1 139 ? 43.090 28.597 -18.973 1.000 16.357 ? 468 ILE EEE C   1 ? 
ATOM   1097 O O   . ILE A 1 139 ? 41.956 28.151 -18.711 1.000 17.876 ? 468 ILE EEE O   1 ? 
ATOM   1098 C CB  . ILE A 1 139 ? 44.122 27.220 -17.081 1.000 18.552 ? 468 ILE EEE CB  1 ? 
ATOM   1099 C CG1 . ILE A 1 139 ? 43.962 28.312 -16.020 1.000 22.325 ? 468 ILE EEE CG1 1 ? 
ATOM   1100 C CG2 . ILE A 1 139 ? 45.263 26.264 -16.751 1.000 18.159 ? 468 ILE EEE CG2 1 ? 
ATOM   1101 C CD1 . ILE A 1 139 ? 43.468 27.802 -14.694 1.000 26.834 ? 468 ILE EEE CD1 1 ? 
ATOM   1102 N N   . SER A 1 140 ? 43.303 29.694 -19.698 1.000 17.565 ? 469 SER EEE N   1 ? 
ATOM   1103 C CA  A SER A 1 140 ? 42.189 30.543 -20.193 0.500 17.035 ? 469 SER EEE CA  1 ? 
ATOM   1104 C CA  B SER A 1 140 ? 42.231 30.570 -20.250 0.500 20.145 ? 469 SER EEE CA  1 ? 
ATOM   1105 C C   . SER A 1 140 ? 41.431 29.817 -21.317 1.000 17.680 ? 469 SER EEE C   1 ? 
ATOM   1106 O O   . SER A 1 140 ? 42.015 28.947 -22.007 1.000 17.485 ? 469 SER EEE O   1 ? 
ATOM   1107 C CB  A SER A 1 140 ? 42.696 31.898 -20.612 0.500 16.063 ? 469 SER EEE CB  1 ? 
ATOM   1108 C CB  B SER A 1 140 ? 42.824 31.834 -20.829 0.500 22.342 ? 469 SER EEE CB  1 ? 
ATOM   1109 O OG  A SER A 1 140 ? 43.537 31.802 -21.746 0.500 14.020 ? 469 SER EEE OG  1 ? 
ATOM   1110 O OG  B SER A 1 140 ? 41.843 32.575 -21.542 0.500 30.434 ? 469 SER EEE OG  1 ? 
ATOM   1111 N N   . THR A 1 141 ? 40.156 30.153 -21.495 1.000 18.424 ? 470 THR EEE N   1 ? 
ATOM   1112 C CA  . THR A 1 141 ? 39.332 29.577 -22.590 1.000 18.312 ? 470 THR EEE CA  1 ? 
ATOM   1113 C C   . THR A 1 141 ? 38.678 30.712 -23.379 1.000 21.451 ? 470 THR EEE C   1 ? 
ATOM   1114 O O   . THR A 1 141 ? 37.545 30.538 -23.852 1.000 24.159 ? 470 THR EEE O   1 ? 
ATOM   1115 C CB  . THR A 1 141 ? 38.310 28.568 -22.060 1.000 20.803 ? 470 THR EEE CB  1 ? 
ATOM   1116 O OG1 . THR A 1 141 ? 37.557 29.187 -21.022 1.000 23.449 ? 470 THR EEE OG1 1 ? 
ATOM   1117 C CG2 . THR A 1 141 ? 38.955 27.299 -21.546 1.000 21.754 ? 470 THR EEE CG2 1 ? 
ATOM   1118 N N   . GLU A 1 142 ? 39.389 31.818 -23.551 1.000 18.534 ? 471 GLU EEE N   1 ? 
ATOM   1119 C CA  . GLU A 1 142 ? 38.892 32.972 -24.339 1.000 20.563 ? 471 GLU EEE CA  1 ? 
ATOM   1120 C C   . GLU A 1 142 ? 38.845 32.565 -25.810 1.000 18.170 ? 471 GLU EEE C   1 ? 
ATOM   1121 O O   . GLU A 1 142 ? 39.750 31.872 -26.278 1.000 17.626 ? 471 GLU EEE O   1 ? 
ATOM   1122 C CB  . GLU A 1 142 ? 39.809 34.182 -24.176 1.000 23.368 ? 471 GLU EEE CB  1 ? 
ATOM   1123 C CG  . GLU A 1 142 ? 39.906 34.695 -22.748 1.000 28.849 ? 471 GLU EEE CG  1 ? 
ATOM   1124 C CD  . GLU A 1 142 ? 38.682 35.405 -22.195 1.000 37.861 ? 471 GLU EEE CD  1 ? 
ATOM   1125 O OE1 . GLU A 1 142 ? 37.800 35.794 -22.990 1.000 41.823 ? 471 GLU EEE OE1 1 ? 
ATOM   1126 O OE2 . GLU A 1 142 ? 38.616 35.570 -20.959 1.000 51.189 ? 471 GLU EEE OE2 1 ? 
ATOM   1127 N N   . ILE A 1 143 ? 37.830 33.019 -26.540 1.000 19.254 ? 472 ILE EEE N   1 ? 
ATOM   1128 C CA  . ILE A 1 143 ? 37.751 32.773 -28.004 1.000 17.172 ? 472 ILE EEE CA  1 ? 
ATOM   1129 C C   . ILE A 1 143 ? 38.922 33.486 -28.683 1.000 19.249 ? 472 ILE EEE C   1 ? 
ATOM   1130 O O   . ILE A 1 143 ? 39.221 34.663 -28.361 1.000 20.834 ? 472 ILE EEE O   1 ? 
ATOM   1131 C CB  . ILE A 1 143 ? 36.375 33.191 -28.548 1.000 18.001 ? 472 ILE EEE CB  1 ? 
ATOM   1132 C CG1 . ILE A 1 143 ? 35.264 32.416 -27.836 1.000 17.141 ? 472 ILE EEE CG1 1 ? 
ATOM   1133 C CG2 . ILE A 1 143 ? 36.320 33.007 -30.056 1.000 17.493 ? 472 ILE EEE CG2 1 ? 
ATOM   1134 C CD1 . ILE A 1 143 ? 35.462 30.916 -27.814 1.000 19.136 ? 472 ILE EEE CD1 1 ? 
ATOM   1135 N N   . TYR A 1 144 ? 39.600 32.753 -29.551 1.000 17.194 ? 473 TYR EEE N   1 ? 
ATOM   1136 C CA  . TYR A 1 144 ? 40.851 33.177 -30.208 1.000 17.348 ? 473 TYR EEE CA  1 ? 
ATOM   1137 C C   . TYR A 1 144 ? 40.519 33.908 -31.506 1.000 17.879 ? 473 TYR EEE C   1 ? 
ATOM   1138 O O   . TYR A 1 144 ? 39.852 33.332 -32.374 1.000 17.373 ? 473 TYR EEE O   1 ? 
ATOM   1139 C CB  . TYR A 1 144 ? 41.725 31.965 -30.496 1.000 17.597 ? 473 TYR EEE CB  1 ? 
ATOM   1140 C CG  . TYR A 1 144 ? 42.971 32.308 -31.255 1.000 17.515 ? 473 TYR EEE CG  1 ? 
ATOM   1141 C CD1 . TYR A 1 144 ? 44.052 32.880 -30.610 1.000 19.552 ? 473 TYR EEE CD1 1 ? 
ATOM   1142 C CD2 . TYR A 1 144 ? 43.067 32.076 -32.615 1.000 18.303 ? 473 TYR EEE CD2 1 ? 
ATOM   1143 C CE1 . TYR A 1 144 ? 45.204 33.214 -31.299 1.000 22.963 ? 473 TYR EEE CE1 1 ? 
ATOM   1144 C CE2 . TYR A 1 144 ? 44.214 32.393 -33.315 1.000 21.077 ? 473 TYR EEE CE2 1 ? 
ATOM   1145 C CZ  . TYR A 1 144 ? 45.288 32.957 -32.652 1.000 23.373 ? 473 TYR EEE CZ  1 ? 
ATOM   1146 O OH  . TYR A 1 144 ? 46.420 33.277 -33.333 1.000 30.286 ? 473 TYR EEE OH  1 ? 
ATOM   1147 N N   . GLN A 1 145 ? 40.992 35.146 -31.631 1.000 18.424 ? 474 GLN EEE N   1 ? 
ATOM   1148 C CA  . GLN A 1 145 ? 40.781 35.959 -32.852 1.000 18.838 ? 474 GLN EEE CA  1 ? 
ATOM   1149 C C   . GLN A 1 145 ? 41.871 35.621 -33.873 1.000 22.260 ? 474 GLN EEE C   1 ? 
ATOM   1150 O O   . GLN A 1 145 ? 43.012 36.095 -33.702 1.000 24.068 ? 474 GLN EEE O   1 ? 
ATOM   1151 C CB  . GLN A 1 145 ? 40.766 37.440 -32.487 1.000 21.142 ? 474 GLN EEE CB  1 ? 
ATOM   1152 C CG  . GLN A 1 145 ? 40.474 38.328 -33.684 1.000 24.839 ? 474 GLN EEE CG  1 ? 
ATOM   1153 C CD  . GLN A 1 145 ? 40.612 39.789 -33.343 1.000 25.650 ? 474 GLN EEE CD  1 ? 
ATOM   1154 O OE1 . GLN A 1 145 ? 40.366 40.201 -32.214 1.000 27.727 ? 474 GLN EEE OE1 1 ? 
ATOM   1155 N NE2 . GLN A 1 145 ? 41.002 40.578 -34.331 1.000 28.244 ? 474 GLN EEE NE2 1 ? 
ATOM   1156 N N   . ALA A 1 146 ? 41.529 34.832 -34.889 1.000 22.247 ? 475 ALA EEE N   1 ? 
ATOM   1157 C CA  . ALA A 1 146 ? 42.458 34.372 -35.948 1.000 22.832 ? 475 ALA EEE CA  1 ? 
ATOM   1158 C C   . ALA A 1 146 ? 42.506 35.384 -37.102 1.000 29.302 ? 475 ALA EEE C   1 ? 
ATOM   1159 O O   . ALA A 1 146 ? 43.450 35.273 -37.912 1.000 31.649 ? 475 ALA EEE O   1 ? 
ATOM   1160 C CB  . ALA A 1 146 ? 42.063 33.006 -36.439 1.000 25.245 ? 475 ALA EEE CB  1 ? 
ATOM   1161 N N   . GLY A 1 147 ? 41.540 36.310 -37.180 1.000 27.846 ? 476 GLY EEE N   1 ? 
ATOM   1162 C CA  . GLY A 1 147 ? 41.419 37.292 -38.281 1.000 30.694 ? 476 GLY EEE CA  1 ? 
ATOM   1163 C C   . GLY A 1 147 ? 41.367 38.724 -37.775 1.000 32.208 ? 476 GLY EEE C   1 ? 
ATOM   1164 O O   . GLY A 1 147 ? 41.787 38.968 -36.634 1.000 28.318 ? 476 GLY EEE O   1 ? 
ATOM   1165 N N   . SER A 1 148 ? 40.876 39.655 -38.601 1.000 33.567 ? 477 SER EEE N   1 ? 
ATOM   1166 C CA  . SER A 1 148 ? 40.914 41.115 -38.318 1.000 34.141 ? 477 SER EEE CA  1 ? 
ATOM   1167 C C   . SER A 1 148 ? 39.714 41.538 -37.461 1.000 32.682 ? 477 SER EEE C   1 ? 
ATOM   1168 O O   . SER A 1 148 ? 39.831 42.581 -36.796 1.000 35.831 ? 477 SER EEE O   1 ? 
ATOM   1169 C CB  . SER A 1 148 ? 41.007 41.932 -39.590 1.000 33.721 ? 477 SER EEE CB  1 ? 
ATOM   1170 O OG  . SER A 1 148 ? 40.064 41.491 -40.553 1.000 42.540 ? 477 SER EEE OG  1 ? 
ATOM   1171 N N   . THR A 1 149 ? 38.614 40.773 -37.462 1.000 30.521 ? 478 THR EEE N   1 ? 
ATOM   1172 C CA  . THR A 1 149 ? 37.353 41.147 -36.762 1.000 32.723 ? 478 THR EEE CA  1 ? 
ATOM   1173 C C   . THR A 1 149 ? 37.351 40.580 -35.348 1.000 30.988 ? 478 THR EEE C   1 ? 
ATOM   1174 O O   . THR A 1 149 ? 37.562 39.383 -35.161 1.000 28.628 ? 478 THR EEE O   1 ? 
ATOM   1175 C CB  . THR A 1 149 ? 36.101 40.679 -37.514 1.000 35.338 ? 478 THR EEE CB  1 ? 
ATOM   1176 O OG1 . THR A 1 149 ? 36.199 41.127 -38.865 1.000 37.934 ? 478 THR EEE OG1 1 ? 
ATOM   1177 C CG2 . THR A 1 149 ? 34.822 41.208 -36.903 1.000 37.941 ? 478 THR EEE CG2 1 ? 
ATOM   1178 N N   . PRO A 1 150 ? 37.109 41.423 -34.319 1.000 30.157 ? 479 PRO EEE N   1 ? 
ATOM   1179 C CA  . PRO A 1 150 ? 36.943 40.947 -32.947 1.000 31.070 ? 479 PRO EEE CA  1 ? 
ATOM   1180 C C   . PRO A 1 150 ? 35.855 39.868 -32.837 1.000 27.535 ? 479 PRO EEE C   1 ? 
ATOM   1181 O O   . PRO A 1 150 ? 34.876 39.926 -33.564 1.000 27.868 ? 479 PRO EEE O   1 ? 
ATOM   1182 C CB  . PRO A 1 150 ? 36.530 42.196 -32.155 1.000 34.621 ? 479 PRO EEE CB  1 ? 
ATOM   1183 C CG  . PRO A 1 150 ? 37.031 43.363 -32.984 1.000 34.785 ? 479 PRO EEE CG  1 ? 
ATOM   1184 C CD  . PRO A 1 150 ? 36.994 42.887 -34.419 1.000 33.022 ? 479 PRO EEE CD  1 ? 
ATOM   1185 N N   . CYS A 1 151 ? 36.046 38.916 -31.924 1.000 24.348 ? 480 CYS EEE N   1 ? 
ATOM   1186 C CA  A CYS A 1 151 ? 35.115 37.777 -31.730 0.500 21.872 ? 480 CYS EEE CA  1 ? 
ATOM   1187 C CA  B CYS A 1 151 ? 35.121 37.767 -31.714 0.500 24.548 ? 480 CYS EEE CA  1 ? 
ATOM   1188 C C   . CYS A 1 151 ? 33.998 38.161 -30.750 1.000 23.422 ? 480 CYS EEE C   1 ? 
ATOM   1189 O O   . CYS A 1 151 ? 32.895 37.634 -30.900 1.000 23.354 ? 480 CYS EEE O   1 ? 
ATOM   1190 C CB  A CYS A 1 151 ? 35.899 36.554 -31.275 0.500 20.041 ? 480 CYS EEE CB  1 ? 
ATOM   1191 C CB  B CYS A 1 151 ? 35.828 36.543 -31.137 0.500 25.540 ? 480 CYS EEE CB  1 ? 
ATOM   1192 S SG  A CYS A 1 151 ? 37.180 36.093 -32.472 0.500 19.386 ? 480 CYS EEE SG  1 ? 
ATOM   1193 S SG  B CYS A 1 151 ? 37.517 36.290 -31.741 0.500 32.843 ? 480 CYS EEE SG  1 ? 
ATOM   1194 N N   . ASN A 1 152 ? 34.282 39.043 -29.783 1.000 26.626 ? 481 ASN EEE N   1 ? 
ATOM   1195 C CA  . ASN A 1 152 ? 33.302 39.428 -28.725 1.000 28.288 ? 481 ASN EEE CA  1 ? 
ATOM   1196 C C   . ASN A 1 152 ? 32.757 38.157 -28.049 1.000 27.779 ? 481 ASN EEE C   1 ? 
ATOM   1197 O O   . ASN A 1 152 ? 31.556 38.110 -27.741 1.000 27.570 ? 481 ASN EEE O   1 ? 
ATOM   1198 C CB  . ASN A 1 152 ? 32.165 40.279 -29.299 1.000 35.957 ? 481 ASN EEE CB  1 ? 
ATOM   1199 C CG  . ASN A 1 152 ? 32.657 41.516 -30.022 1.000 44.467 ? 481 ASN EEE CG  1 ? 
ATOM   1200 O OD1 . ASN A 1 152 ? 33.513 42.239 -29.515 1.000 50.064 ? 481 ASN EEE OD1 1 ? 
ATOM   1201 N ND2 . ASN A 1 152 ? 32.116 41.773 -31.203 1.000 51.751 ? 481 ASN EEE ND2 1 ? 
ATOM   1202 N N   . GLY A 1 153 ? 33.598 37.133 -27.888 1.000 26.094 ? 482 GLY EEE N   1 ? 
ATOM   1203 C CA  . GLY A 1 153 ? 33.290 35.903 -27.134 1.000 25.390 ? 482 GLY EEE CA  1 ? 
ATOM   1204 C C   . GLY A 1 153 ? 32.425 34.942 -27.928 1.000 24.157 ? 482 GLY EEE C   1 ? 
ATOM   1205 O O   . GLY A 1 153 ? 31.917 33.978 -27.332 1.000 26.944 ? 482 GLY EEE O   1 ? 
ATOM   1206 N N   . VAL A 1 154 ? 32.265 35.181 -29.230 1.000 22.248 ? 483 VAL EEE N   1 ? 
ATOM   1207 C CA  . VAL A 1 154 ? 31.376 34.374 -30.114 1.000 22.789 ? 483 VAL EEE CA  1 ? 
ATOM   1208 C C   . VAL A 1 154 ? 32.241 33.635 -31.136 1.000 20.760 ? 483 VAL EEE C   1 ? 
ATOM   1209 O O   . VAL A 1 154 ? 32.995 34.278 -31.883 1.000 22.029 ? 483 VAL EEE O   1 ? 
ATOM   1210 C CB  . VAL A 1 154 ? 30.306 35.253 -30.789 1.000 24.766 ? 483 VAL EEE CB  1 ? 
ATOM   1211 C CG1 . VAL A 1 154 ? 29.417 34.446 -31.724 1.000 26.592 ? 483 VAL EEE CG1 1 ? 
ATOM   1212 C CG2 . VAL A 1 154 ? 29.463 35.978 -29.753 1.000 26.875 ? 483 VAL EEE CG2 1 ? 
ATOM   1213 N N   . GLU A 1 155 ? 32.125 32.310 -31.176 1.000 18.717 ? 484 GLU EEE N   1 ? 
ATOM   1214 C CA  . GLU A 1 155 ? 32.848 31.486 -32.167 1.000 17.218 ? 484 GLU EEE CA  1 ? 
ATOM   1215 C C   . GLU A 1 155 ? 32.234 31.697 -33.549 1.000 19.542 ? 484 GLU EEE C   1 ? 
ATOM   1216 O O   . GLU A 1 155 ? 31.006 31.926 -33.639 1.000 22.647 ? 484 GLU EEE O   1 ? 
ATOM   1217 C CB  . GLU A 1 155 ? 32.789 30.017 -31.777 1.000 17.869 ? 484 GLU EEE CB  1 ? 
ATOM   1218 C CG  . GLU A 1 155 ? 33.441 29.753 -30.442 1.000 16.707 ? 484 GLU EEE CG  1 ? 
ATOM   1219 C CD  . GLU A 1 155 ? 33.373 28.292 -30.034 1.000 17.519 ? 484 GLU EEE CD  1 ? 
ATOM   1220 O OE1 . GLU A 1 155 ? 33.760 27.441 -30.852 1.000 16.878 ? 484 GLU EEE OE1 1 ? 
ATOM   1221 O OE2 . GLU A 1 155 ? 32.898 28.014 -28.915 1.000 18.017 ? 484 GLU EEE OE2 1 ? 
ATOM   1222 N N   . GLY A 1 156 ? 33.054 31.548 -34.580 1.000 19.704 ? 485 GLY EEE N   1 ? 
ATOM   1223 C CA  . GLY A 1 156 ? 32.630 31.692 -35.981 1.000 22.453 ? 485 GLY EEE CA  1 ? 
ATOM   1224 C C   . GLY A 1 156 ? 33.820 31.743 -36.909 1.000 22.450 ? 485 GLY EEE C   1 ? 
ATOM   1225 O O   . GLY A 1 156 ? 34.871 31.166 -36.576 1.000 20.436 ? 485 GLY EEE O   1 ? 
ATOM   1226 N N   . PHE A 1 157 ? 33.648 32.391 -38.064 1.000 25.168 ? 486 PHE EEE N   1 ? 
ATOM   1227 C CA  . PHE A 1 157 ? 34.719 32.631 -39.061 1.000 27.407 ? 486 PHE EEE CA  1 ? 
ATOM   1228 C C   . PHE A 1 157 ? 35.903 33.280 -38.334 1.000 22.386 ? 486 PHE EEE C   1 ? 
ATOM   1229 O O   . PHE A 1 157 ? 35.732 34.375 -37.776 1.000 22.362 ? 486 PHE EEE O   1 ? 
ATOM   1230 C CB  . PHE A 1 157 ? 34.173 33.489 -40.209 1.000 29.136 ? 486 PHE EEE CB  1 ? 
ATOM   1231 C CG  . PHE A 1 157 ? 35.176 33.822 -41.283 1.000 36.585 ? 486 PHE EEE CG  1 ? 
ATOM   1232 C CD1 . PHE A 1 157 ? 35.659 32.835 -42.130 1.000 43.774 ? 486 PHE EEE CD1 1 ? 
ATOM   1233 C CD2 . PHE A 1 157 ? 35.640 35.120 -41.445 1.000 40.102 ? 486 PHE EEE CD2 1 ? 
ATOM   1234 C CE1 . PHE A 1 157 ? 36.583 33.141 -43.118 1.000 44.786 ? 486 PHE EEE CE1 1 ? 
ATOM   1235 C CE2 . PHE A 1 157 ? 36.563 35.424 -42.436 1.000 41.522 ? 486 PHE EEE CE2 1 ? 
ATOM   1236 C CZ  . PHE A 1 157 ? 37.034 34.433 -43.268 1.000 43.968 ? 486 PHE EEE CZ  1 ? 
ATOM   1237 N N   . ASN A 1 158 ? 37.038 32.578 -38.290 1.000 22.081 ? 487 ASN EEE N   1 ? 
ATOM   1238 C CA  . ASN A 1 158 ? 38.330 33.068 -37.739 1.000 21.504 ? 487 ASN EEE CA  1 ? 
ATOM   1239 C C   . ASN A 1 158 ? 38.186 33.409 -36.251 1.000 20.414 ? 487 ASN EEE C   1 ? 
ATOM   1240 O O   . ASN A 1 158 ? 38.957 34.254 -35.771 1.000 20.381 ? 487 ASN EEE O   1 ? 
ATOM   1241 C CB  . ASN A 1 158 ? 38.854 34.275 -38.524 1.000 25.169 ? 487 ASN EEE CB  1 ? 
ATOM   1242 C CG  . ASN A 1 158 ? 39.288 33.910 -39.926 1.000 30.512 ? 487 ASN EEE CG  1 ? 
ATOM   1243 O OD1 . ASN A 1 158 ? 39.652 32.765 -40.192 1.000 38.026 ? 487 ASN EEE OD1 1 ? 
ATOM   1244 N ND2 . ASN A 1 158 ? 39.254 34.877 -40.827 1.000 39.485 ? 487 ASN EEE ND2 1 ? 
ATOM   1245 N N   . CYS A 1 159 ? 37.222 32.795 -35.559 1.000 17.545 ? 488 CYS EEE N   1 ? 
ATOM   1246 C CA  A CYS A 1 159 ? 36.997 32.967 -34.096 0.500 17.504 ? 488 CYS EEE CA  1 ? 
ATOM   1247 C CA  B CYS A 1 159 ? 37.022 32.959 -34.094 0.500 17.318 ? 488 CYS EEE CA  1 ? 
ATOM   1248 C C   . CYS A 1 159 ? 36.834 31.578 -33.463 1.000 17.345 ? 488 CYS EEE C   1 ? 
ATOM   1249 O O   . CYS A 1 159 ? 35.749 30.986 -33.608 1.000 16.882 ? 488 CYS EEE O   1 ? 
ATOM   1250 C CB  A CYS A 1 159 ? 35.779 33.841 -33.821 0.500 17.611 ? 488 CYS EEE CB  1 ? 
ATOM   1251 C CB  B CYS A 1 159 ? 35.849 33.883 -33.811 0.500 17.015 ? 488 CYS EEE CB  1 ? 
ATOM   1252 S SG  A CYS A 1 159 ? 36.076 35.612 -34.085 0.500 19.873 ? 488 CYS EEE SG  1 ? 
ATOM   1253 S SG  B CYS A 1 159 ? 36.070 35.504 -34.589 0.500 20.462 ? 488 CYS EEE SG  1 ? 
ATOM   1254 N N   . TYR A 1 160 ? 37.884 31.082 -32.816 1.000 15.721 ? 489 TYR EEE N   1 ? 
ATOM   1255 C CA  . TYR A 1 160 ? 37.989 29.649 -32.456 1.000 16.324 ? 489 TYR EEE CA  1 ? 
ATOM   1256 C C   . TYR A 1 160 ? 38.045 29.449 -30.951 1.000 16.415 ? 489 TYR EEE C   1 ? 
ATOM   1257 O O   . TYR A 1 160 ? 38.598 30.274 -30.207 1.000 17.158 ? 489 TYR EEE O   1 ? 
ATOM   1258 C CB  . TYR A 1 160 ? 39.236 29.041 -33.086 1.000 17.763 ? 489 TYR EEE CB  1 ? 
ATOM   1259 C CG  . TYR A 1 160 ? 39.320 29.219 -34.577 1.000 20.214 ? 489 TYR EEE CG  1 ? 
ATOM   1260 C CD1 . TYR A 1 160 ? 38.211 29.006 -35.381 1.000 22.234 ? 489 TYR EEE CD1 1 ? 
ATOM   1261 C CD2 . TYR A 1 160 ? 40.513 29.575 -35.180 1.000 24.323 ? 489 TYR EEE CD2 1 ? 
ATOM   1262 C CE1 . TYR A 1 160 ? 38.289 29.149 -36.757 1.000 24.082 ? 489 TYR EEE CE1 1 ? 
ATOM   1263 C CE2 . TYR A 1 160 ? 40.606 29.724 -36.553 1.000 27.224 ? 489 TYR EEE CE2 1 ? 
ATOM   1264 C CZ  . TYR A 1 160 ? 39.490 29.507 -37.341 1.000 25.327 ? 489 TYR EEE CZ  1 ? 
ATOM   1265 O OH  . TYR A 1 160 ? 39.584 29.649 -38.700 1.000 32.795 ? 489 TYR EEE OH  1 ? 
ATOM   1266 N N   . PHE A 1 161 ? 37.487 28.331 -30.512 1.000 14.796 ? 490 PHE EEE N   1 ? 
ATOM   1267 C CA  . PHE A 1 161 ? 37.720 27.829 -29.142 1.000 14.596 ? 490 PHE EEE CA  1 ? 
ATOM   1268 C C   . PHE A 1 161 ? 39.179 27.392 -29.093 1.000 14.390 ? 490 PHE EEE C   1 ? 
ATOM   1269 O O   . PHE A 1 161 ? 39.654 26.695 -29.985 1.000 15.627 ? 490 PHE EEE O   1 ? 
ATOM   1270 C CB  . PHE A 1 161 ? 36.745 26.706 -28.811 1.000 14.423 ? 490 PHE EEE CB  1 ? 
ATOM   1271 C CG  . PHE A 1 161 ? 36.744 26.365 -27.352 1.000 15.686 ? 490 PHE EEE CG  1 ? 
ATOM   1272 C CD1 . PHE A 1 161 ? 36.089 27.180 -26.446 1.000 16.972 ? 490 PHE EEE CD1 1 ? 
ATOM   1273 C CD2 . PHE A 1 161 ? 37.427 25.258 -26.880 1.000 16.296 ? 490 PHE EEE CD2 1 ? 
ATOM   1274 C CE1 . PHE A 1 161 ? 36.108 26.888 -25.094 1.000 18.075 ? 490 PHE EEE CE1 1 ? 
ATOM   1275 C CE2 . PHE A 1 161 ? 37.441 24.969 -25.526 1.000 16.972 ? 490 PHE EEE CE2 1 ? 
ATOM   1276 C CZ  . PHE A 1 161 ? 36.770 25.774 -24.639 1.000 18.713 ? 490 PHE EEE CZ  1 ? 
ATOM   1277 N N   . PRO A 1 162 ? 39.974 27.809 -28.087 1.000 14.988 ? 491 PRO EEE N   1 ? 
ATOM   1278 C CA  . PRO A 1 162 ? 41.419 27.592 -28.149 1.000 14.206 ? 491 PRO EEE CA  1 ? 
ATOM   1279 C C   . PRO A 1 162 ? 41.955 26.201 -27.777 1.000 13.924 ? 491 PRO EEE C   1 ? 
ATOM   1280 O O   . PRO A 1 162 ? 43.139 25.958 -28.050 1.000 14.263 ? 491 PRO EEE O   1 ? 
ATOM   1281 C CB  . PRO A 1 162 ? 41.940 28.644 -27.152 1.000 14.996 ? 491 PRO EEE CB  1 ? 
ATOM   1282 C CG  . PRO A 1 162 ? 40.850 28.722 -26.124 1.000 15.065 ? 491 PRO EEE CG  1 ? 
ATOM   1283 C CD  . PRO A 1 162 ? 39.561 28.575 -26.906 1.000 13.977 ? 491 PRO EEE CD  1 ? 
ATOM   1284 N N   . LEU A 1 163 ? 41.136 25.359 -27.133 1.000 14.410 ? 492 LEU EEE N   1 ? 
ATOM   1285 C CA  . LEU A 1 163 ? 41.553 24.005 -26.695 1.000 13.296 ? 492 LEU EEE CA  1 ? 
ATOM   1286 C C   . LEU A 1 163 ? 40.943 22.948 -27.612 1.000 13.442 ? 492 LEU EEE C   1 ? 
ATOM   1287 O O   . LEU A 1 163 ? 39.887 23.194 -28.215 1.000 14.260 ? 492 LEU EEE O   1 ? 
ATOM   1288 C CB  . LEU A 1 163 ? 41.118 23.740 -25.256 1.000 13.265 ? 492 LEU EEE CB  1 ? 
ATOM   1289 C CG  . LEU A 1 163 ? 41.488 24.811 -24.235 1.000 15.020 ? 492 LEU EEE CG  1 ? 
ATOM   1290 C CD1 . LEU A 1 163 ? 41.028 24.387 -22.848 1.000 16.530 ? 492 LEU EEE CD1 1 ? 
ATOM   1291 C CD2 . LEU A 1 163 ? 42.980 25.103 -24.242 1.000 15.899 ? 492 LEU EEE CD2 1 ? 
ATOM   1292 N N   . GLN A 1 164 ? 41.583 21.783 -27.658 1.000 13.075 ? 493 GLN EEE N   1 ? 
ATOM   1293 C CA  . GLN A 1 164 ? 41.130 20.640 -28.468 1.000 12.533 ? 493 GLN EEE CA  1 ? 
ATOM   1294 C C   . GLN A 1 164 ? 41.510 19.341 -27.756 1.000 12.815 ? 493 GLN EEE C   1 ? 
ATOM   1295 O O   . GLN A 1 164 ? 42.594 19.254 -27.140 1.000 13.170 ? 493 GLN EEE O   1 ? 
ATOM   1296 C CB  . GLN A 1 164 ? 41.730 20.733 -29.870 1.000 13.300 ? 493 GLN EEE CB  1 ? 
ATOM   1297 C CG  . GLN A 1 164 ? 41.216 19.672 -30.822 1.000 13.154 ? 493 GLN EEE CG  1 ? 
ATOM   1298 C CD  . GLN A 1 164 ? 41.190 20.224 -32.224 1.000 14.204 ? 493 GLN EEE CD  1 ? 
ATOM   1299 O OE1 . GLN A 1 164 ? 40.218 20.849 -32.639 1.000 15.145 ? 493 GLN EEE OE1 1 ? 
ATOM   1300 N NE2 . GLN A 1 164 ? 42.280 20.021 -32.951 1.000 14.895 ? 493 GLN EEE NE2 1 ? 
ATOM   1301 N N   . SER A 1 165 ? 40.635 18.352 -27.856 1.000 12.722 ? 494 SER EEE N   1 ? 
ATOM   1302 C CA  . SER A 1 165 ? 40.855 16.987 -27.328 1.000 12.630 ? 494 SER EEE CA  1 ? 
ATOM   1303 C C   . SER A 1 165 ? 41.950 16.270 -28.109 1.000 12.484 ? 494 SER EEE C   1 ? 
ATOM   1304 O O   . SER A 1 165 ? 41.879 16.212 -29.356 1.000 14.616 ? 494 SER EEE O   1 ? 
ATOM   1305 C CB  . SER A 1 165 ? 39.598 16.161 -27.394 1.000 13.081 ? 494 SER EEE CB  1 ? 
ATOM   1306 O OG  . SER A 1 165 ? 38.640 16.604 -26.463 1.000 13.861 ? 494 SER EEE OG  1 ? 
ATOM   1307 N N   . TYR A 1 166 ? 42.842 15.596 -27.386 1.000 12.715 ? 495 TYR EEE N   1 ? 
ATOM   1308 C CA  . TYR A 1 166 ? 43.468 14.352 -27.876 1.000 12.792 ? 495 TYR EEE CA  1 ? 
ATOM   1309 C C   . TYR A 1 166 ? 42.388 13.266 -27.920 1.000 14.341 ? 495 TYR EEE C   1 ? 
ATOM   1310 O O   . TYR A 1 166 ? 41.542 13.227 -27.010 1.000 15.416 ? 495 TYR EEE O   1 ? 
ATOM   1311 C CB  . TYR A 1 166 ? 44.572 13.876 -26.938 1.000 12.912 ? 495 TYR EEE CB  1 ? 
ATOM   1312 C CG  . TYR A 1 166 ? 45.804 14.738 -26.860 1.000 14.799 ? 495 TYR EEE CG  1 ? 
ATOM   1313 C CD1 . TYR A 1 166 ? 46.679 14.849 -27.928 1.000 14.813 ? 495 TYR EEE CD1 1 ? 
ATOM   1314 C CD2 . TYR A 1 166 ? 46.145 15.361 -25.675 1.000 15.582 ? 495 TYR EEE CD2 1 ? 
ATOM   1315 C CE1 . TYR A 1 166 ? 47.848 15.585 -27.826 1.000 15.315 ? 495 TYR EEE CE1 1 ? 
ATOM   1316 C CE2 . TYR A 1 166 ? 47.298 16.114 -25.559 1.000 15.646 ? 495 TYR EEE CE2 1 ? 
ATOM   1317 C CZ  . TYR A 1 166 ? 48.154 16.220 -26.639 1.000 15.860 ? 495 TYR EEE CZ  1 ? 
ATOM   1318 O OH  . TYR A 1 166 ? 49.300 16.948 -26.545 1.000 18.132 ? 495 TYR EEE OH  1 ? 
ATOM   1319 N N   . GLY A 1 167 ? 42.408 12.430 -28.955 1.000 14.289 ? 496 GLY EEE N   1 ? 
ATOM   1320 C CA  . GLY A 1 167 ? 41.535 11.247 -29.071 1.000 15.654 ? 496 GLY EEE CA  1 ? 
ATOM   1321 C C   . GLY A 1 167 ? 42.337 9.980  -28.849 1.000 15.758 ? 496 GLY EEE C   1 ? 
ATOM   1322 O O   . GLY A 1 167 ? 42.844 9.410  -29.838 1.000 17.893 ? 496 GLY EEE O   1 ? 
ATOM   1323 N N   . PHE A 1 168 ? 42.465 9.550  -27.594 1.000 14.814 ? 497 PHE EEE N   1 ? 
ATOM   1324 C CA  . PHE A 1 168 ? 43.311 8.387  -27.226 1.000 15.787 ? 497 PHE EEE CA  1 ? 
ATOM   1325 C C   . PHE A 1 168 ? 42.479 7.102  -27.267 1.000 17.489 ? 497 PHE EEE C   1 ? 
ATOM   1326 O O   . PHE A 1 168 ? 41.600 6.894  -26.410 1.000 18.012 ? 497 PHE EEE O   1 ? 
ATOM   1327 C CB  . PHE A 1 168 ? 43.934 8.594  -25.848 1.000 14.985 ? 497 PHE EEE CB  1 ? 
ATOM   1328 C CG  . PHE A 1 168 ? 44.977 9.682  -25.799 1.000 14.334 ? 497 PHE EEE CG  1 ? 
ATOM   1329 C CD1 . PHE A 1 168 ? 46.036 9.708  -26.697 1.000 15.874 ? 497 PHE EEE CD1 1 ? 
ATOM   1330 C CD2 . PHE A 1 168 ? 44.927 10.651 -24.807 1.000 13.802 ? 497 PHE EEE CD2 1 ? 
ATOM   1331 C CE1 . PHE A 1 168 ? 46.984 10.718 -26.635 1.000 15.169 ? 497 PHE EEE CE1 1 ? 
ATOM   1332 C CE2 . PHE A 1 168 ? 45.890 11.648 -24.736 1.000 13.953 ? 497 PHE EEE CE2 1 ? 
ATOM   1333 C CZ  . PHE A 1 168 ? 46.923 11.670 -25.643 1.000 14.256 ? 497 PHE EEE CZ  1 ? 
ATOM   1334 N N   . GLN A 1 169 ? 42.783 6.266  -28.256 1.000 19.235 ? 498 GLN EEE N   1 ? 
ATOM   1335 C CA  . GLN A 1 169 ? 42.183 4.925  -28.453 1.000 19.878 ? 498 GLN EEE CA  1 ? 
ATOM   1336 C C   . GLN A 1 169 ? 43.313 3.916  -28.364 1.000 18.713 ? 498 GLN EEE C   1 ? 
ATOM   1337 O O   . GLN A 1 169 ? 44.410 4.174  -28.849 1.000 18.860 ? 498 GLN EEE O   1 ? 
ATOM   1338 C CB  . GLN A 1 169 ? 41.502 4.841  -29.816 1.000 22.272 ? 498 GLN EEE CB  1 ? 
ATOM   1339 C CG  . GLN A 1 169 ? 40.359 5.822  -29.998 1.000 25.244 ? 498 GLN EEE CG  1 ? 
ATOM   1340 C CD  . GLN A 1 169 ? 39.737 5.647  -31.358 1.000 31.215 ? 498 GLN EEE CD  1 ? 
ATOM   1341 O OE1 . GLN A 1 169 ? 39.146 4.612  -31.658 1.000 34.607 ? 498 GLN EEE OE1 1 ? 
ATOM   1342 N NE2 . GLN A 1 169 ? 39.905 6.645  -32.206 1.000 34.180 ? 498 GLN EEE NE2 1 ? 
ATOM   1343 N N   . PRO A 1 170 ? 43.089 2.740  -27.741 1.000 20.489 ? 499 PRO EEE N   1 ? 
ATOM   1344 C CA  . PRO A 1 170 ? 44.178 1.788  -27.516 1.000 21.057 ? 499 PRO EEE CA  1 ? 
ATOM   1345 C C   . PRO A 1 170 ? 44.796 1.210  -28.799 1.000 20.674 ? 499 PRO EEE C   1 ? 
ATOM   1346 O O   . PRO A 1 170 ? 45.929 0.771  -28.735 1.000 24.889 ? 499 PRO EEE O   1 ? 
ATOM   1347 C CB  . PRO A 1 170 ? 43.541 0.693  -26.650 1.000 23.016 ? 499 PRO EEE CB  1 ? 
ATOM   1348 C CG  . PRO A 1 170 ? 42.044 0.855  -26.817 1.000 23.240 ? 499 PRO EEE CG  1 ? 
ATOM   1349 C CD  . PRO A 1 170 ? 41.799 2.298  -27.201 1.000 20.881 ? 499 PRO EEE CD  1 ? 
ATOM   1350 N N   . THR A 1 171 ? 44.066 1.276  -29.917 1.000 22.047 ? 500 THR EEE N   1 ? 
ATOM   1351 C CA  . THR A 1 171 ? 44.501 0.821  -31.264 1.000 24.382 ? 500 THR EEE CA  1 ? 
ATOM   1352 C C   . THR A 1 171 ? 45.258 1.921  -32.026 1.000 24.805 ? 500 THR EEE C   1 ? 
ATOM   1353 O O   . THR A 1 171 ? 45.753 1.631  -33.128 1.000 25.992 ? 500 THR EEE O   1 ? 
ATOM   1354 C CB  . THR A 1 171 ? 43.290 0.339  -32.070 1.000 26.692 ? 500 THR EEE CB  1 ? 
ATOM   1355 O OG1 . THR A 1 171 ? 42.281 1.344  -31.956 1.000 30.276 ? 500 THR EEE OG1 1 ? 
ATOM   1356 C CG2 . THR A 1 171 ? 42.760 -0.992 -31.585 1.000 30.542 ? 500 THR EEE CG2 1 ? 
ATOM   1357 N N   . ASN A 1 172 ? 45.394 3.133  -31.477 1.000 21.599 ? 501 ASN EEE N   1 ? 
ATOM   1358 C CA  . ASN A 1 172 ? 46.224 4.193  -32.105 1.000 21.243 ? 501 ASN EEE CA  1 ? 
ATOM   1359 C C   . ASN A 1 172 ? 47.663 3.688  -32.275 1.000 19.503 ? 501 ASN EEE C   1 ? 
ATOM   1360 O O   . ASN A 1 172 ? 48.109 2.840  -31.469 1.000 20.522 ? 501 ASN EEE O   1 ? 
ATOM   1361 C CB  . ASN A 1 172 ? 46.259 5.481  -31.269 1.000 18.543 ? 501 ASN EEE CB  1 ? 
ATOM   1362 C CG  . ASN A 1 172 ? 44.978 6.292  -31.301 1.000 23.120 ? 501 ASN EEE CG  1 ? 
ATOM   1363 O OD1 . ASN A 1 172 ? 44.013 5.939  -31.982 1.000 23.523 ? 501 ASN EEE OD1 1 ? 
ATOM   1364 N ND2 . ASN A 1 172 ? 44.965 7.400  -30.569 1.000 19.129 ? 501 ASN EEE ND2 1 ? 
ATOM   1365 N N   . GLY A 1 173 ? 48.376 4.204  -33.275 1.000 20.155 ? 502 GLY EEE N   1 ? 
ATOM   1366 C CA  . GLY A 1 173 ? 49.838 4.060  -33.375 1.000 21.300 ? 502 GLY EEE CA  1 ? 
ATOM   1367 C C   . GLY A 1 173 ? 50.497 4.657  -32.144 1.000 19.116 ? 502 GLY EEE C   1 ? 
ATOM   1368 O O   . GLY A 1 173 ? 49.885 5.557  -31.532 1.000 19.595 ? 502 GLY EEE O   1 ? 
ATOM   1369 N N   . VAL A 1 174 ? 51.668 4.159  -31.759 1.000 21.224 ? 503 VAL EEE N   1 ? 
ATOM   1370 C CA  A VAL A 1 174 ? 52.420 4.596  -30.543 0.500 21.663 ? 503 VAL EEE CA  1 ? 
ATOM   1371 C CA  B VAL A 1 174 ? 52.325 4.607  -30.493 0.500 20.678 ? 503 VAL EEE CA  1 ? 
ATOM   1372 C C   . VAL A 1 174 ? 52.549 6.127  -30.544 1.000 18.924 ? 503 VAL EEE C   1 ? 
ATOM   1373 O O   . VAL A 1 174 ? 52.502 6.742  -29.470 1.000 18.414 ? 503 VAL EEE O   1 ? 
ATOM   1374 C CB  A VAL A 1 174 ? 53.804 3.915  -30.481 0.500 25.211 ? 503 VAL EEE CB  1 ? 
ATOM   1375 C CB  B VAL A 1 174 ? 53.622 3.840  -30.162 0.500 23.336 ? 503 VAL EEE CB  1 ? 
ATOM   1376 C CG1 A VAL A 1 174 ? 54.702 4.310  -31.645 0.500 26.746 ? 503 VAL EEE CG1 1 ? 
ATOM   1377 C CG1 B VAL A 1 174 ? 53.323 2.472  -29.570 0.500 22.589 ? 503 VAL EEE CG1 1 ? 
ATOM   1378 C CG2 A VAL A 1 174 ? 54.504 4.182  -29.159 0.500 26.762 ? 503 VAL EEE CG2 1 ? 
ATOM   1379 C CG2 B VAL A 1 174 ? 54.568 3.725  -31.346 0.500 23.395 ? 503 VAL EEE CG2 1 ? 
ATOM   1380 N N   . GLY A 1 175 ? 52.738 6.718  -31.721 1.000 18.561 ? 504 GLY EEE N   1 ? 
ATOM   1381 C CA  . GLY A 1 175 ? 52.890 8.178  -31.863 1.000 17.908 ? 504 GLY EEE CA  1 ? 
ATOM   1382 C C   . GLY A 1 175 ? 51.660 8.930  -31.379 1.000 18.035 ? 504 GLY EEE C   1 ? 
ATOM   1383 O O   . GLY A 1 175 ? 51.812 10.102 -30.947 1.000 19.369 ? 504 GLY EEE O   1 ? 
ATOM   1384 N N   . TYR A 1 176 ? 50.477 8.321  -31.469 1.000 16.923 ? 505 TYR EEE N   1 ? 
ATOM   1385 C CA  . TYR A 1 176 ? 49.209 8.928  -30.986 1.000 18.121 ? 505 TYR EEE CA  1 ? 
ATOM   1386 C C   . TYR A 1 176 ? 48.685 8.156  -29.772 1.000 17.865 ? 505 TYR EEE C   1 ? 
ATOM   1387 O O   . TYR A 1 176 ? 47.466 8.169  -29.510 1.000 20.284 ? 505 TYR EEE O   1 ? 
ATOM   1388 C CB  . TYR A 1 176 ? 48.143 8.997  -32.085 1.000 18.705 ? 505 TYR EEE CB  1 ? 
ATOM   1389 C CG  . TYR A 1 176 ? 47.028 9.998  -31.846 1.000 21.335 ? 505 TYR EEE CG  1 ? 
ATOM   1390 C CD1 . TYR A 1 176 ? 46.890 10.716 -30.658 1.000 20.421 ? 505 TYR EEE CD1 1 ? 
ATOM   1391 C CD2 . TYR A 1 176 ? 46.087 10.235 -32.836 1.000 23.652 ? 505 TYR EEE CD2 1 ? 
ATOM   1392 C CE1 . TYR A 1 176 ? 45.853 11.619 -30.465 1.000 20.447 ? 505 TYR EEE CE1 1 ? 
ATOM   1393 C CE2 . TYR A 1 176 ? 45.051 11.139 -32.662 1.000 22.431 ? 505 TYR EEE CE2 1 ? 
ATOM   1394 C CZ  . TYR A 1 176 ? 44.932 11.841 -31.476 1.000 21.873 ? 505 TYR EEE CZ  1 ? 
ATOM   1395 O OH  . TYR A 1 176 ? 43.916 12.751 -31.318 1.000 21.528 ? 505 TYR EEE OH  1 ? 
ATOM   1396 N N   . GLN A 1 177 ? 49.570 7.487  -29.034 1.000 16.538 ? 506 GLN EEE N   1 ? 
ATOM   1397 C CA  . GLN A 1 177 ? 49.200 6.916  -27.722 1.000 15.457 ? 506 GLN EEE CA  1 ? 
ATOM   1398 C C   . GLN A 1 177 ? 49.544 7.948  -26.659 1.000 14.325 ? 506 GLN EEE C   1 ? 
ATOM   1399 O O   . GLN A 1 177 ? 50.432 8.773  -26.856 1.000 14.737 ? 506 GLN EEE O   1 ? 
ATOM   1400 C CB  . GLN A 1 177 ? 49.868 5.562  -27.489 1.000 16.214 ? 506 GLN EEE CB  1 ? 
ATOM   1401 C CG  . GLN A 1 177 ? 49.192 4.467  -28.297 1.000 17.709 ? 506 GLN EEE CG  1 ? 
ATOM   1402 C CD  . GLN A 1 177 ? 49.793 3.103  -28.085 1.000 20.135 ? 506 GLN EEE CD  1 ? 
ATOM   1403 O OE1 . GLN A 1 177 ? 50.521 2.859  -27.132 1.000 20.930 ? 506 GLN EEE OE1 1 ? 
ATOM   1404 N NE2 . GLN A 1 177 ? 49.482 2.193  -28.996 1.000 22.060 ? 506 GLN EEE NE2 1 ? 
ATOM   1405 N N   . PRO A 1 178 ? 48.833 7.924  -25.520 1.000 14.397 ? 507 PRO EEE N   1 ? 
ATOM   1406 C CA  . PRO A 1 178 ? 49.116 8.852  -24.429 1.000 13.677 ? 507 PRO EEE CA  1 ? 
ATOM   1407 C C   . PRO A 1 178 ? 50.415 8.453  -23.732 1.000 14.673 ? 507 PRO EEE C   1 ? 
ATOM   1408 O O   . PRO A 1 178 ? 50.648 7.274  -23.494 1.000 15.915 ? 507 PRO EEE O   1 ? 
ATOM   1409 C CB  . PRO A 1 178 ? 47.901 8.726  -23.514 1.000 14.592 ? 507 PRO EEE CB  1 ? 
ATOM   1410 C CG  . PRO A 1 178 ? 47.458 7.291  -23.733 1.000 15.135 ? 507 PRO EEE CG  1 ? 
ATOM   1411 C CD  . PRO A 1 178 ? 47.737 6.999  -25.192 1.000 15.250 ? 507 PRO EEE CD  1 ? 
ATOM   1412 N N   . TYR A 1 179 ? 51.230 9.462  -23.433 1.000 13.762 ? 508 TYR EEE N   1 ? 
ATOM   1413 C CA  . TYR A 1 179 ? 52.431 9.353  -22.575 1.000 13.768 ? 508 TYR EEE CA  1 ? 
ATOM   1414 C C   . TYR A 1 179 ? 52.241 10.262 -21.369 1.000 13.945 ? 508 TYR EEE C   1 ? 
ATOM   1415 O O   . TYR A 1 179 ? 51.874 11.447 -21.517 1.000 15.396 ? 508 TYR EEE O   1 ? 
ATOM   1416 C CB  . TYR A 1 179 ? 53.703 9.704  -23.349 1.000 14.826 ? 508 TYR EEE CB  1 ? 
ATOM   1417 C CG  . TYR A 1 179 ? 54.154 8.551  -24.203 1.000 14.509 ? 508 TYR EEE CG  1 ? 
ATOM   1418 C CD1 . TYR A 1 179 ? 53.357 8.110  -25.243 1.000 14.577 ? 508 TYR EEE CD1 1 ? 
ATOM   1419 C CD2 . TYR A 1 179 ? 55.310 7.848  -23.915 1.000 16.554 ? 508 TYR EEE CD2 1 ? 
ATOM   1420 C CE1 . TYR A 1 179 ? 53.715 7.017  -26.012 1.000 16.303 ? 508 TYR EEE CE1 1 ? 
ATOM   1421 C CE2 . TYR A 1 179 ? 55.672 6.742  -24.664 1.000 16.660 ? 508 TYR EEE CE2 1 ? 
ATOM   1422 C CZ  . TYR A 1 179 ? 54.872 6.330  -25.714 1.000 17.935 ? 508 TYR EEE CZ  1 ? 
ATOM   1423 O OH  . TYR A 1 179 ? 55.228 5.240  -26.454 1.000 20.072 ? 508 TYR EEE OH  1 ? 
ATOM   1424 N N   . ARG A 1 180 ? 52.523 9.711  -20.196 1.000 14.160 ? 509 ARG EEE N   1 ? 
ATOM   1425 C CA  . ARG A 1 180 ? 52.626 10.484 -18.951 1.000 14.156 ? 509 ARG EEE CA  1 ? 
ATOM   1426 C C   . ARG A 1 180 ? 54.050 11.012 -18.869 1.000 14.008 ? 509 ARG EEE C   1 ? 
ATOM   1427 O O   . ARG A 1 180 ? 55.002 10.275 -19.184 1.000 15.397 ? 509 ARG EEE O   1 ? 
ATOM   1428 C CB  . ARG A 1 180 ? 52.223 9.633  -17.754 1.000 14.920 ? 509 ARG EEE CB  1 ? 
ATOM   1429 C CG  . ARG A 1 180 ? 50.720 9.441  -17.682 1.000 15.570 ? 509 ARG EEE CG  1 ? 
ATOM   1430 C CD  . ARG A 1 180 ? 50.256 8.615  -16.504 1.000 17.041 ? 509 ARG EEE CD  1 ? 
ATOM   1431 N NE  . ARG A 1 180 ? 48.807 8.535  -16.553 1.000 17.173 ? 509 ARG EEE NE  1 ? 
ATOM   1432 C CZ  . ARG A 1 180 ? 48.023 8.249  -15.530 1.000 19.132 ? 509 ARG EEE CZ  1 ? 
ATOM   1433 N NH1 . ARG A 1 180 ? 48.548 7.975  -14.345 1.000 21.874 ? 509 ARG EEE NH1 1 ? 
ATOM   1434 N NH2 . ARG A 1 180 ? 46.713 8.218  -15.697 1.000 19.672 ? 509 ARG EEE NH2 1 ? 
ATOM   1435 N N   . VAL A 1 181 ? 54.150 12.284 -18.521 1.000 14.272 ? 510 VAL EEE N   1 ? 
ATOM   1436 C CA  . VAL A 1 181 ? 55.429 13.028 -18.483 1.000 13.998 ? 510 VAL EEE CA  1 ? 
ATOM   1437 C C   . VAL A 1 181 ? 55.577 13.614 -17.087 1.000 14.054 ? 510 VAL EEE C   1 ? 
ATOM   1438 O O   . VAL A 1 181 ? 54.610 14.208 -16.573 1.000 15.164 ? 510 VAL EEE O   1 ? 
ATOM   1439 C CB  . VAL A 1 181 ? 55.471 14.115 -19.569 1.000 14.948 ? 510 VAL EEE CB  1 ? 
ATOM   1440 C CG1 . VAL A 1 181 ? 56.781 14.879 -19.533 1.000 15.017 ? 510 VAL EEE CG1 1 ? 
ATOM   1441 C CG2 . VAL A 1 181 ? 55.235 13.516 -20.944 1.000 14.724 ? 510 VAL EEE CG2 1 ? 
ATOM   1442 N N   . VAL A 1 182 ? 56.768 13.451 -16.514 1.000 14.033 ? 511 VAL EEE N   1 ? 
ATOM   1443 C CA  . VAL A 1 182 ? 57.190 14.177 -15.290 1.000 13.596 ? 511 VAL EEE CA  1 ? 
ATOM   1444 C C   . VAL A 1 182 ? 58.476 14.927 -15.620 1.000 14.330 ? 511 VAL EEE C   1 ? 
ATOM   1445 O O   . VAL A 1 182 ? 59.446 14.326 -16.117 1.000 15.736 ? 511 VAL EEE O   1 ? 
ATOM   1446 C CB  . VAL A 1 182 ? 57.357 13.256 -14.072 1.000 15.008 ? 511 VAL EEE CB  1 ? 
ATOM   1447 C CG1 . VAL A 1 182 ? 57.856 14.053 -12.866 1.000 16.588 ? 511 VAL EEE CG1 1 ? 
ATOM   1448 C CG2 . VAL A 1 182 ? 56.058 12.527 -13.755 1.000 14.866 ? 511 VAL EEE CG2 1 ? 
ATOM   1449 N N   . VAL A 1 183 ? 58.468 16.227 -15.367 1.000 14.764 ? 512 VAL EEE N   1 ? 
ATOM   1450 C CA  . VAL A 1 183 ? 59.673 17.076 -15.520 1.000 15.492 ? 512 VAL EEE CA  1 ? 
ATOM   1451 C C   . VAL A 1 183 ? 60.138 17.415 -14.108 1.000 15.243 ? 512 VAL EEE C   1 ? 
ATOM   1452 O O   . VAL A 1 183 ? 59.339 17.993 -13.356 1.000 15.339 ? 512 VAL EEE O   1 ? 
ATOM   1453 C CB  . VAL A 1 183 ? 59.377 18.346 -16.327 1.000 16.666 ? 512 VAL EEE CB  1 ? 
ATOM   1454 C CG1 . VAL A 1 183 ? 60.617 19.211 -16.460 1.000 17.158 ? 512 VAL EEE CG1 1 ? 
ATOM   1455 C CG2 . VAL A 1 183 ? 58.799 18.010 -17.694 1.000 18.051 ? 512 VAL EEE CG2 1 ? 
ATOM   1456 N N   . LEU A 1 184 ? 61.357 17.028 -13.762 1.000 15.953 ? 513 LEU EEE N   1 ? 
ATOM   1457 C CA  . LEU A 1 184 ? 61.965 17.426 -12.474 1.000 15.987 ? 513 LEU EEE CA  1 ? 
ATOM   1458 C C   . LEU A 1 184 ? 62.902 18.606 -12.717 1.000 16.809 ? 513 LEU EEE C   1 ? 
ATOM   1459 O O   . LEU A 1 184 ? 63.796 18.494 -13.575 1.000 17.514 ? 513 LEU EEE O   1 ? 
ATOM   1460 C CB  . LEU A 1 184 ? 62.710 16.241 -11.863 1.000 16.972 ? 513 LEU EEE CB  1 ? 
ATOM   1461 C CG  . LEU A 1 184 ? 61.884 14.985 -11.609 1.000 18.333 ? 513 LEU EEE CG  1 ? 
ATOM   1462 C CD1 . LEU A 1 184 ? 62.769 13.887 -11.032 1.000 21.295 ? 513 LEU EEE CD1 1 ? 
ATOM   1463 C CD2 . LEU A 1 184 ? 60.710 15.263 -10.685 1.000 18.627 ? 513 LEU EEE CD2 1 ? 
ATOM   1464 N N   . SER A 1 185 ? 62.659 19.708 -12.005 1.000 17.799 ? 514 SER EEE N   1 ? 
ATOM   1465 C CA  . SER A 1 185 ? 63.497 20.929 -11.986 1.000 21.159 ? 514 SER EEE CA  1 ? 
ATOM   1466 C C   . SER A 1 185 ? 64.242 20.965 -10.654 1.000 20.213 ? 514 SER EEE C   1 ? 
ATOM   1467 O O   . SER A 1 185 ? 63.581 20.832 -9.614  1.000 19.712 ? 514 SER EEE O   1 ? 
ATOM   1468 C CB  . SER A 1 185 ? 62.669 22.173 -12.175 1.000 22.774 ? 514 SER EEE CB  1 ? 
ATOM   1469 O OG  . SER A 1 185 ? 62.251 22.289 -13.516 1.000 29.490 ? 514 SER EEE OG  1 ? 
ATOM   1470 N N   . PHE A 1 186 ? 65.560 21.146 -10.697 1.000 22.079 ? 515 PHE EEE N   1 ? 
ATOM   1471 C CA  . PHE A 1 186 ? 66.426 21.154 -9.491  1.000 24.260 ? 515 PHE EEE CA  1 ? 
ATOM   1472 C C   . PHE A 1 186 ? 66.890 22.586 -9.240  1.000 28.097 ? 515 PHE EEE C   1 ? 
ATOM   1473 O O   . PHE A 1 186 ? 67.594 23.143 -10.103 1.000 28.861 ? 515 PHE EEE O   1 ? 
ATOM   1474 C CB  . PHE A 1 186 ? 67.612 20.208 -9.666  1.000 24.744 ? 515 PHE EEE CB  1 ? 
ATOM   1475 C CG  . PHE A 1 186 ? 67.218 18.779 -9.929  1.000 25.311 ? 515 PHE EEE CG  1 ? 
ATOM   1476 C CD1 . PHE A 1 186 ? 66.730 17.977 -8.912  1.000 25.989 ? 515 PHE EEE CD1 1 ? 
ATOM   1477 C CD2 . PHE A 1 186 ? 67.351 18.239 -11.194 1.000 29.871 ? 515 PHE EEE CD2 1 ? 
ATOM   1478 C CE1 . PHE A 1 186 ? 66.360 16.664 -9.162  1.000 29.639 ? 515 PHE EEE CE1 1 ? 
ATOM   1479 C CE2 . PHE A 1 186 ? 66.986 16.924 -11.443 1.000 31.065 ? 515 PHE EEE CE2 1 ? 
ATOM   1480 C CZ  . PHE A 1 186 ? 66.484 16.144 -10.427 1.000 26.858 ? 515 PHE EEE CZ  1 ? 
ATOM   1481 N N   . GLU A 1 187 ? 66.487 23.140 -8.098  1.000 28.513 ? 516 GLU EEE N   1 ? 
ATOM   1482 C CA  . GLU A 1 187 ? 66.726 24.554 -7.723  1.000 30.973 ? 516 GLU EEE CA  1 ? 
ATOM   1483 C C   . GLU A 1 187 ? 67.739 24.608 -6.575  1.000 26.635 ? 516 GLU EEE C   1 ? 
ATOM   1484 O O   . GLU A 1 187 ? 67.473 24.013 -5.513  1.000 28.360 ? 516 GLU EEE O   1 ? 
ATOM   1485 C CB  . GLU A 1 187 ? 65.395 25.201 -7.346  1.000 31.658 ? 516 GLU EEE CB  1 ? 
ATOM   1486 C CG  . GLU A 1 187 ? 65.499 26.685 -7.066  1.000 33.920 ? 516 GLU EEE CG  1 ? 
ATOM   1487 C CD  . GLU A 1 187 ? 64.170 27.321 -6.706  1.000 33.680 ? 516 GLU EEE CD  1 ? 
ATOM   1488 O OE1 . GLU A 1 187 ? 63.704 28.182 -7.480  1.000 39.569 ? 516 GLU EEE OE1 1 ? 
ATOM   1489 O OE2 . GLU A 1 187 ? 63.603 26.944 -5.661  1.000 35.881 ? 516 GLU EEE OE2 1 ? 
ATOM   1490 N N   . LEU A 1 188 ? 68.846 25.322 -6.792  1.000 37.258 ? 517 LEU EEE N   1 ? 
ATOM   1491 C CA  . LEU A 1 188 ? 69.858 25.644 -5.752  1.000 40.997 ? 517 LEU EEE CA  1 ? 
ATOM   1492 C C   . LEU A 1 188 ? 69.845 27.164 -5.536  1.000 38.839 ? 517 LEU EEE C   1 ? 
ATOM   1493 O O   . LEU A 1 188 ? 70.206 27.897 -6.466  1.000 41.676 ? 517 LEU EEE O   1 ? 
ATOM   1494 C CB  . LEU A 1 188 ? 71.236 25.115 -6.176  1.000 48.764 ? 517 LEU EEE CB  1 ? 
ATOM   1495 C CG  . LEU A 1 188 ? 71.758 25.557 -7.547  1.000 59.211 ? 517 LEU EEE CG  1 ? 
ATOM   1496 C CD1 . LEU A 1 188 ? 72.844 26.616 -7.410  1.000 64.348 ? 517 LEU EEE CD1 1 ? 
ATOM   1497 C CD2 . LEU A 1 188 ? 72.291 24.368 -8.334  1.000 62.409 ? 517 LEU EEE CD2 1 ? 
ATOM   1498 N N   . LEU A 1 189 ? 69.352 27.603 -4.376  1.000 40.527 ? 518 LEU EEE N   1 ? 
ATOM   1499 C CA  . LEU A 1 189 ? 69.352 29.025 -3.937  1.000 44.101 ? 518 LEU EEE CA  1 ? 
ATOM   1500 C C   . LEU A 1 189 ? 70.287 29.155 -2.731  1.000 46.079 ? 518 LEU EEE C   1 ? 
ATOM   1501 O O   . LEU A 1 189 ? 70.728 28.116 -2.212  1.000 40.645 ? 518 LEU EEE O   1 ? 
ATOM   1502 C CB  . LEU A 1 189 ? 67.927 29.445 -3.560  1.000 45.461 ? 518 LEU EEE CB  1 ? 
ATOM   1503 C CG  . LEU A 1 189 ? 66.857 29.274 -4.639  1.000 47.284 ? 518 LEU EEE CG  1 ? 
ATOM   1504 C CD1 . LEU A 1 189 ? 65.488 29.656 -4.099  1.000 50.007 ? 518 LEU EEE CD1 1 ? 
ATOM   1505 C CD2 . LEU A 1 189 ? 67.182 30.089 -5.881  1.000 49.964 ? 518 LEU EEE CD2 1 ? 
ATOM   1506 N N   . HIS A 1 190 ? 70.567 30.386 -2.299  1.000 48.484 ? 519 HIS EEE N   1 ? 
ATOM   1507 C CA  . HIS A 1 190 ? 71.217 30.684 -0.995  1.000 49.666 ? 519 HIS EEE CA  1 ? 
ATOM   1508 C C   . HIS A 1 190 ? 70.229 30.397 0.136   1.000 56.670 ? 519 HIS EEE C   1 ? 
ATOM   1509 O O   . HIS A 1 190 ? 69.570 31.345 0.613   1.000 68.727 ? 519 HIS EEE O   1 ? 
ATOM   1510 C CB  . HIS A 1 190 ? 71.709 32.131 -0.937  1.000 47.211 ? 519 HIS EEE CB  1 ? 
ATOM   1511 C CG  . HIS A 1 190 ? 72.815 32.417 -1.890  1.000 43.624 ? 519 HIS EEE CG  1 ? 
ATOM   1512 N ND1 . HIS A 1 190 ? 74.094 31.937 -1.697  1.000 43.030 ? 519 HIS EEE ND1 1 ? 
ATOM   1513 C CD2 . HIS A 1 190 ? 72.838 33.123 -3.038  1.000 42.332 ? 519 HIS EEE CD2 1 ? 
ATOM   1514 C CE1 . HIS A 1 190 ? 74.864 32.342 -2.687  1.000 45.190 ? 519 HIS EEE CE1 1 ? 
ATOM   1515 N NE2 . HIS A 1 190 ? 74.117 33.073 -3.522  1.000 46.409 ? 519 HIS EEE NE2 1 ? 
ATOM   1516 N N   . ALA A 1 191 ? 70.132 29.131 0.534   1.000 52.496 ? 520 ALA EEE N   1 ? 
ATOM   1517 C CA  . ALA A 1 191 ? 69.292 28.651 1.653   1.000 53.204 ? 520 ALA EEE CA  1 ? 
ATOM   1518 C C   . ALA A 1 191 ? 69.772 27.257 2.039   1.000 55.483 ? 520 ALA EEE C   1 ? 
ATOM   1519 O O   . ALA A 1 191 ? 70.591 26.674 1.331   1.000 59.115 ? 520 ALA EEE O   1 ? 
ATOM   1520 C CB  . ALA A 1 191 ? 67.840 28.661 1.243   1.000 49.322 ? 520 ALA EEE CB  1 ? 
ATOM   1521 N N   . PRO A 1 192 ? 69.296 26.680 3.164   1.000 55.521 ? 521 PRO EEE N   1 ? 
ATOM   1522 C CA  . PRO A 1 192 ? 69.587 25.282 3.471   1.000 54.703 ? 521 PRO EEE CA  1 ? 
ATOM   1523 C C   . PRO A 1 192 ? 69.099 24.396 2.314   1.000 47.948 ? 521 PRO EEE C   1 ? 
ATOM   1524 O O   . PRO A 1 192 ? 67.972 24.564 1.900   1.000 50.385 ? 521 PRO EEE O   1 ? 
ATOM   1525 C CB  . PRO A 1 192 ? 68.817 25.020 4.776   1.000 59.203 ? 521 PRO EEE CB  1 ? 
ATOM   1526 C CG  . PRO A 1 192 ? 68.618 26.398 5.380   1.000 56.662 ? 521 PRO EEE CG  1 ? 
ATOM   1527 C CD  . PRO A 1 192 ? 68.465 27.325 4.193   1.000 57.390 ? 521 PRO EEE CD  1 ? 
ATOM   1528 N N   . ALA A 1 193 ? 69.963 23.519 1.793   1.000 46.081 ? 522 ALA EEE N   1 ? 
ATOM   1529 C CA  . ALA A 1 193 ? 69.617 22.532 0.743   1.000 40.839 ? 522 ALA EEE CA  1 ? 
ATOM   1530 C C   . ALA A 1 193 ? 68.827 21.392 1.396   1.000 42.800 ? 522 ALA EEE C   1 ? 
ATOM   1531 O O   . ALA A 1 193 ? 69.454 20.532 2.041   1.000 53.187 ? 522 ALA EEE O   1 ? 
ATOM   1532 C CB  . ALA A 1 193 ? 70.864 22.046 0.047   1.000 39.347 ? 522 ALA EEE CB  1 ? 
ATOM   1533 N N   . THR A 1 194 ? 67.503 21.399 1.220   1.000 36.263 ? 523 THR EEE N   1 ? 
ATOM   1534 C CA  . THR A 1 194 ? 66.517 20.614 2.009   1.000 37.628 ? 523 THR EEE CA  1 ? 
ATOM   1535 C C   . THR A 1 194 ? 66.182 19.285 1.316   1.000 31.150 ? 523 THR EEE C   1 ? 
ATOM   1536 O O   . THR A 1 194 ? 65.489 18.464 1.945   1.000 32.075 ? 523 THR EEE O   1 ? 
ATOM   1537 C CB  . THR A 1 194 ? 65.247 21.442 2.248   1.000 42.875 ? 523 THR EEE CB  1 ? 
ATOM   1538 O OG1 . THR A 1 194 ? 64.559 21.605 1.006   1.000 42.739 ? 523 THR EEE OG1 1 ? 
ATOM   1539 C CG2 . THR A 1 194 ? 65.533 22.803 2.847   1.000 45.508 ? 523 THR EEE CG2 1 ? 
ATOM   1540 N N   . VAL A 1 195 ? 66.645 19.072 0.079   1.000 31.404 ? 524 VAL EEE N   1 ? 
ATOM   1541 C CA  . VAL A 1 195 ? 66.408 17.804 -0.677  1.000 30.616 ? 524 VAL EEE CA  1 ? 
ATOM   1542 C C   . VAL A 1 195 ? 67.758 17.199 -1.057  1.000 27.755 ? 524 VAL EEE C   1 ? 
ATOM   1543 O O   . VAL A 1 195 ? 68.398 17.707 -1.992  1.000 27.440 ? 524 VAL EEE O   1 ? 
ATOM   1544 C CB  . VAL A 1 195 ? 65.518 18.020 -1.915  1.000 32.102 ? 524 VAL EEE CB  1 ? 
ATOM   1545 C CG1 . VAL A 1 195 ? 65.201 16.704 -2.609  1.000 30.593 ? 524 VAL EEE CG1 1 ? 
ATOM   1546 C CG2 . VAL A 1 195 ? 64.239 18.745 -1.551  1.000 30.543 ? 524 VAL EEE CG2 1 ? 
ATOM   1547 N N   . CYS A 1 196 ? 68.157 16.140 -0.354  1.000 30.852 ? 525 CYS EEE N   1 ? 
ATOM   1548 C CA  . CYS A 1 196 ? 69.466 15.469 -0.532  1.000 35.512 ? 525 CYS EEE CA  1 ? 
ATOM   1549 C C   . CYS A 1 196 ? 69.241 13.992 -0.863  1.000 33.380 ? 525 CYS EEE C   1 ? 
ATOM   1550 O O   . CYS A 1 196 ? 68.186 13.444 -0.480  1.000 30.700 ? 525 CYS EEE O   1 ? 
ATOM   1551 C CB  . CYS A 1 196 ? 70.320 15.632 0.719   1.000 39.731 ? 525 CYS EEE CB  1 ? 
ATOM   1552 S SG  . CYS A 1 196 ? 70.835 17.348 0.991   1.000 44.511 ? 525 CYS EEE SG  1 ? 
ATOM   1553 N N   . GLY A 1 197 ? 70.200 13.387 -1.564  1.000 38.754 ? 526 GLY EEE N   1 ? 
ATOM   1554 C CA  . GLY A 1 197 ? 70.283 11.928 -1.738  1.000 38.167 ? 526 GLY EEE CA  1 ? 
ATOM   1555 C C   . GLY A 1 197 ? 70.514 11.230 -0.401  1.000 40.417 ? 526 GLY EEE C   1 ? 
ATOM   1556 O O   . GLY A 1 197 ? 70.720 11.886 0.619   1.000 40.524 ? 526 GLY EEE O   1 ? 
ATOM   1557 N N   . PRO A 1 198 ? 70.486 9.879  -0.358  1.000 40.691 ? 527 PRO EEE N   1 ? 
ATOM   1558 C CA  . PRO A 1 198 ? 70.780 9.141  0.868   1.000 46.691 ? 527 PRO EEE CA  1 ? 
ATOM   1559 C C   . PRO A 1 198 ? 72.284 9.177  1.182   1.000 41.037 ? 527 PRO EEE C   1 ? 
ATOM   1560 O O   . PRO A 1 198 ? 72.663 9.268  2.347   1.000 54.689 ? 527 PRO EEE O   1 ? 
ATOM   1561 C CB  . PRO A 1 198 ? 70.299 7.709  0.568   1.000 44.403 ? 527 PRO EEE CB  1 ? 
ATOM   1562 C CG  . PRO A 1 198 ? 69.547 7.809  -0.753  1.000 43.678 ? 527 PRO EEE CG  1 ? 
ATOM   1563 C CD  . PRO A 1 198 ? 70.167 8.983  -1.476  1.000 38.832 ? 527 PRO EEE CD  1 ? 
ATOM   1564 N N   . GLN B 2 1   ? 23.722 5.511  -16.612 1.000 44.465 ? 1   GLN FFF N   1 ? 
ATOM   1565 C CA  . GLN B 2 1   ? 24.692 6.597  -16.255 1.000 45.534 ? 1   GLN FFF CA  1 ? 
ATOM   1566 C C   . GLN B 2 1   ? 24.253 7.906  -16.907 1.000 34.511 ? 1   GLN FFF C   1 ? 
ATOM   1567 O O   . GLN B 2 1   ? 23.682 8.750  -16.195 1.000 37.696 ? 1   GLN FFF O   1 ? 
ATOM   1568 C CB  . GLN B 2 1   ? 26.116 6.240  -16.682 1.000 50.813 ? 1   GLN FFF CB  1 ? 
ATOM   1569 C CG  . GLN B 2 1   ? 26.885 5.508  -15.601 1.000 60.179 ? 1   GLN FFF CG  1 ? 
ATOM   1570 C CD  . GLN B 2 1   ? 25.982 4.567  -14.840 1.000 60.093 ? 1   GLN FFF CD  1 ? 
ATOM   1571 O OE1 . GLN B 2 1   ? 25.376 3.658  -15.403 1.000 75.848 ? 1   GLN FFF OE1 1 ? 
ATOM   1572 N NE2 . GLN B 2 1   ? 25.857 4.801  -13.548 1.000 39.344 ? 1   GLN FFF NE2 1 ? 
ATOM   1573 N N   . VAL B 2 2   ? 24.503 8.056  -18.208 1.000 29.681 ? 2   VAL FFF N   1 ? 
ATOM   1574 C CA  . VAL B 2 2   ? 24.180 9.311  -18.949 1.000 23.926 ? 2   VAL FFF CA  1 ? 
ATOM   1575 C C   . VAL B 2 2   ? 22.860 9.093  -19.686 1.000 22.730 ? 2   VAL FFF C   1 ? 
ATOM   1576 O O   . VAL B 2 2   ? 22.742 8.090  -20.420 1.000 25.034 ? 2   VAL FFF O   1 ? 
ATOM   1577 C CB  . VAL B 2 2   ? 25.304 9.724  -19.913 1.000 26.132 ? 2   VAL FFF CB  1 ? 
ATOM   1578 C CG1 . VAL B 2 2   ? 24.955 11.018 -20.637 1.000 24.012 ? 2   VAL FFF CG1 1 ? 
ATOM   1579 C CG2 . VAL B 2 2   ? 26.643 9.851  -19.198 1.000 27.008 ? 2   VAL FFF CG2 1 ? 
ATOM   1580 N N   . GLN B 2 3   ? 21.898 9.991  -19.476 1.000 20.862 ? 3   GLN FFF N   1 ? 
ATOM   1581 C CA  . GLN B 2 3   ? 20.579 9.944  -20.144 1.000 19.312 ? 3   GLN FFF CA  1 ? 
ATOM   1582 C C   . GLN B 2 3   ? 20.285 11.315 -20.749 1.000 18.407 ? 3   GLN FFF C   1 ? 
ATOM   1583 O O   . GLN B 2 3   ? 20.444 12.337 -20.054 1.000 17.694 ? 3   GLN FFF O   1 ? 
ATOM   1584 C CB  . GLN B 2 3   ? 19.454 9.557  -19.183 1.000 26.668 ? 3   GLN FFF CB  1 ? 
ATOM   1585 C CG  . GLN B 2 3   ? 19.626 8.192  -18.536 1.000 32.901 ? 3   GLN FFF CG  1 ? 
ATOM   1586 C CD  . GLN B 2 3   ? 18.748 8.053  -17.314 1.000 48.127 ? 3   GLN FFF CD  1 ? 
ATOM   1587 O OE1 . GLN B 2 3   ? 17.546 8.309  -17.359 1.000 53.490 ? 3   GLN FFF OE1 1 ? 
ATOM   1588 N NE2 . GLN B 2 3   ? 19.349 7.651  -16.205 1.000 57.986 ? 3   GLN FFF NE2 1 ? 
ATOM   1589 N N   . LEU B 2 4   ? 19.886 11.312 -22.016 1.000 16.380 ? 4   LEU FFF N   1 ? 
ATOM   1590 C CA  . LEU B 2 4   ? 19.334 12.483 -22.738 1.000 15.375 ? 4   LEU FFF CA  1 ? 
ATOM   1591 C C   . LEU B 2 4   ? 17.846 12.219 -22.954 1.000 17.009 ? 4   LEU FFF C   1 ? 
ATOM   1592 O O   . LEU B 2 4   ? 17.525 11.237 -23.648 1.000 18.804 ? 4   LEU FFF O   1 ? 
ATOM   1593 C CB  . LEU B 2 4   ? 20.052 12.639 -24.080 1.000 14.934 ? 4   LEU FFF CB  1 ? 
ATOM   1594 C CG  . LEU B 2 4   ? 21.370 13.404 -24.074 1.000 16.500 ? 4   LEU FFF CG  1 ? 
ATOM   1595 C CD1 . LEU B 2 4   ? 22.351 12.836 -23.065 1.000 18.393 ? 4   LEU FFF CD1 1 ? 
ATOM   1596 C CD2 . LEU B 2 4   ? 21.980 13.391 -25.469 1.000 16.379 ? 4   LEU FFF CD2 1 ? 
ATOM   1597 N N   . VAL B 2 5   ? 16.981 13.010 -22.320 1.000 17.578 ? 5   VAL FFF N   1 ? 
ATOM   1598 C CA  . VAL B 2 5   ? 15.507 12.796 -22.352 1.000 18.945 ? 5   VAL FFF CA  1 ? 
ATOM   1599 C C   . VAL B 2 5   ? 14.844 13.977 -23.063 1.000 16.529 ? 5   VAL FFF C   1 ? 
ATOM   1600 O O   . VAL B 2 5   ? 14.872 15.102 -22.525 1.000 17.870 ? 5   VAL FFF O   1 ? 
ATOM   1601 C CB  . VAL B 2 5   ? 14.931 12.584 -20.943 1.000 22.770 ? 5   VAL FFF CB  1 ? 
ATOM   1602 C CG1 . VAL B 2 5   ? 13.427 12.350 -20.999 1.000 24.711 ? 5   VAL FFF CG1 1 ? 
ATOM   1603 C CG2 . VAL B 2 5   ? 15.625 11.435 -20.230 1.000 24.180 ? 5   VAL FFF CG2 1 ? 
ATOM   1604 N N   . GLU B 2 6   ? 14.285 13.717 -24.241 1.000 17.301 ? 6   GLU FFF N   1 ? 
ATOM   1605 C CA  . GLU B 2 6   ? 13.622 14.744 -25.078 1.000 17.579 ? 6   GLU FFF CA  1 ? 
ATOM   1606 C C   . GLU B 2 6   ? 12.176 14.918 -24.624 1.000 18.786 ? 6   GLU FFF C   1 ? 
ATOM   1607 O O   . GLU B 2 6   ? 11.552 13.941 -24.188 1.000 19.659 ? 6   GLU FFF O   1 ? 
ATOM   1608 C CB  . GLU B 2 6   ? 13.633 14.366 -26.552 1.000 20.389 ? 6   GLU FFF CB  1 ? 
ATOM   1609 C CG  . GLU B 2 6   ? 15.019 14.267 -27.135 1.000 21.097 ? 6   GLU FFF CG  1 ? 
ATOM   1610 C CD  . GLU B 2 6   ? 15.097 13.337 -28.327 1.000 24.672 ? 6   GLU FFF CD  1 ? 
ATOM   1611 O OE1 . GLU B 2 6   ? 14.027 12.937 -28.838 1.000 29.881 ? 6   GLU FFF OE1 1 ? 
ATOM   1612 O OE2 . GLU B 2 6   ? 16.214 12.980 -28.710 1.000 20.374 ? 6   GLU FFF OE2 1 ? 
ATOM   1613 N N   . SER B 2 7   ? 11.681 16.148 -24.713 1.000 18.421 ? 7   SER FFF N   1 ? 
ATOM   1614 C CA  . SER B 2 7   ? 10.240 16.460 -24.579 1.000 18.043 ? 7   SER FFF CA  1 ? 
ATOM   1615 C C   . SER B 2 7   ? 9.876  17.512 -25.618 1.000 18.295 ? 7   SER FFF C   1 ? 
ATOM   1616 O O   . SER B 2 7   ? 10.781 18.198 -26.147 1.000 18.348 ? 7   SER FFF O   1 ? 
ATOM   1617 C CB  . SER B 2 7   ? 9.888  16.893 -23.184 1.000 20.905 ? 7   SER FFF CB  1 ? 
ATOM   1618 O OG  . SER B 2 7   ? 10.745 17.930 -22.760 1.000 22.260 ? 7   SER FFF OG  1 ? 
ATOM   1619 N N   . GLY B 2 8   ? 8.584  17.608 -25.905 1.000 17.736 ? 8   GLY FFF N   1 ? 
ATOM   1620 C CA  . GLY B 2 8   ? 8.031  18.556 -26.883 1.000 18.104 ? 8   GLY FFF CA  1 ? 
ATOM   1621 C C   . GLY B 2 8   ? 7.893  17.908 -28.245 1.000 18.585 ? 8   GLY FFF C   1 ? 
ATOM   1622 O O   . GLY B 2 8   ? 7.954  16.667 -28.343 1.000 21.209 ? 8   GLY FFF O   1 ? 
ATOM   1623 N N   . GLY B 2 9   ? 7.713  18.729 -29.269 1.000 19.329 ? 9   GLY FFF N   1 ? 
ATOM   1624 C CA  . GLY B 2 9   ? 7.533  18.256 -30.650 1.000 19.354 ? 9   GLY FFF CA  1 ? 
ATOM   1625 C C   . GLY B 2 9   ? 6.088  17.910 -30.942 1.000 20.058 ? 9   GLY FFF C   1 ? 
ATOM   1626 O O   . GLY B 2 9   ? 5.184  18.483 -30.286 1.000 22.246 ? 9   GLY FFF O   1 ? 
ATOM   1627 N N   . GLY B 2 10  ? 5.883  17.035 -31.922 1.000 18.660 ? 10  GLY FFF N   1 ? 
ATOM   1628 C CA  . GLY B 2 10  ? 4.556  16.584 -32.375 1.000 17.987 ? 10  GLY FFF CA  1 ? 
ATOM   1629 C C   . GLY B 2 10  ? 4.095  17.372 -33.583 1.000 18.495 ? 10  GLY FFF C   1 ? 
ATOM   1630 O O   . GLY B 2 10  ? 4.936  17.721 -34.439 1.000 17.489 ? 10  GLY FFF O   1 ? 
ATOM   1631 N N   . LEU B 2 11  ? 2.803  17.679 -33.631 1.000 19.126 ? 11  LEU FFF N   1 ? 
ATOM   1632 C CA  . LEU B 2 11  ? 2.128  18.236 -34.829 1.000 19.130 ? 11  LEU FFF CA  1 ? 
ATOM   1633 C C   . LEU B 2 11  ? 2.074  19.759 -34.722 1.000 20.728 ? 11  LEU FFF C   1 ? 
ATOM   1634 O O   . LEU B 2 11  ? 1.757  20.296 -33.625 1.000 22.667 ? 11  LEU FFF O   1 ? 
ATOM   1635 C CB  . LEU B 2 11  ? 0.731  17.619 -34.918 1.000 21.852 ? 11  LEU FFF CB  1 ? 
ATOM   1636 C CG  . LEU B 2 11  ? -0.117 18.055 -36.106 1.000 21.856 ? 11  LEU FFF CG  1 ? 
ATOM   1637 C CD1 . LEU B 2 11  ? 0.454  17.525 -37.409 1.000 24.410 ? 11  LEU FFF CD1 1 ? 
ATOM   1638 C CD2 . LEU B 2 11  ? -1.548 17.582 -35.915 1.000 24.369 ? 11  LEU FFF CD2 1 ? 
ATOM   1639 N N   . MET B 2 12  ? 2.361  20.441 -35.829 1.000 18.017 ? 12  MET FFF N   1 ? 
ATOM   1640 C CA  . MET B 2 12  ? 2.188  21.905 -35.948 1.000 18.092 ? 12  MET FFF CA  1 ? 
ATOM   1641 C C   . MET B 2 12  ? 1.932  22.272 -37.407 1.000 17.616 ? 12  MET FFF C   1 ? 
ATOM   1642 O O   . MET B 2 12  ? 2.504  21.633 -38.307 1.000 17.613 ? 12  MET FFF O   1 ? 
ATOM   1643 C CB  . MET B 2 12  ? 3.425  22.652 -35.439 1.000 19.419 ? 12  MET FFF CB  1 ? 
ATOM   1644 C CG  . MET B 2 12  ? 3.279  24.161 -35.388 1.000 19.656 ? 12  MET FFF CG  1 ? 
ATOM   1645 S SD  . MET B 2 12  ? 1.793  24.739 -34.507 1.000 23.373 ? 12  MET FFF SD  1 ? 
ATOM   1646 C CE  . MET B 2 12  ? 2.018  23.925 -32.931 1.000 23.671 ? 12  MET FFF CE  1 ? 
ATOM   1647 N N   . GLN B 2 13  ? 1.121  23.300 -37.619 1.000 19.462 ? 13  GLN FFF N   1 ? 
ATOM   1648 C CA  . GLN B 2 13  ? 0.853  23.831 -38.970 1.000 20.496 ? 13  GLN FFF CA  1 ? 
ATOM   1649 C C   . GLN B 2 13  ? 2.103  24.534 -39.506 1.000 19.635 ? 13  GLN FFF C   1 ? 
ATOM   1650 O O   . GLN B 2 13  ? 2.881  25.134 -38.716 1.000 18.400 ? 13  GLN FFF O   1 ? 
ATOM   1651 C CB  . GLN B 2 13  ? -0.385 24.728 -38.931 1.000 26.291 ? 13  GLN FFF CB  1 ? 
ATOM   1652 C CG  . GLN B 2 13  ? -1.676 23.922 -38.831 1.000 36.603 ? 13  GLN FFF CG  1 ? 
ATOM   1653 C CD  . GLN B 2 13  ? -2.929 24.754 -38.971 1.000 49.125 ? 13  GLN FFF CD  1 ? 
ATOM   1654 O OE1 . GLN B 2 13  ? -3.865 24.383 -39.681 1.000 66.397 ? 13  GLN FFF OE1 1 ? 
ATOM   1655 N NE2 . GLN B 2 13  ? -2.960 25.888 -38.288 1.000 55.217 ? 13  GLN FFF NE2 1 ? 
ATOM   1656 N N   . ALA B 2 14  ? 2.294  24.473 -40.821 1.000 16.302 ? 14  ALA FFF N   1 ? 
ATOM   1657 C CA  . ALA B 2 14  ? 3.370  25.184 -41.536 1.000 16.937 ? 14  ALA FFF CA  1 ? 
ATOM   1658 C C   . ALA B 2 14  ? 3.330  26.667 -41.158 1.000 19.329 ? 14  ALA FFF C   1 ? 
ATOM   1659 O O   . ALA B 2 14  ? 2.214  27.231 -41.030 1.000 20.022 ? 14  ALA FFF O   1 ? 
ATOM   1660 C CB  . ALA B 2 14  ? 3.226  24.982 -43.022 1.000 18.212 ? 14  ALA FFF CB  1 ? 
ATOM   1661 N N   . GLY B 2 15  ? 4.507  27.255 -40.947 1.000 18.361 ? 15  GLY FFF N   1 ? 
ATOM   1662 C CA  . GLY B 2 15  ? 4.668  28.659 -40.529 1.000 20.156 ? 15  GLY FFF CA  1 ? 
ATOM   1663 C C   . GLY B 2 15  ? 4.604  28.818 -39.018 1.000 18.439 ? 15  GLY FFF C   1 ? 
ATOM   1664 O O   . GLY B 2 15  ? 4.946  29.907 -38.533 1.000 20.537 ? 15  GLY FFF O   1 ? 
ATOM   1665 N N   . GLY B 2 16  ? 4.171  27.787 -38.294 1.000 18.701 ? 16  GLY FFF N   1 ? 
ATOM   1666 C CA  . GLY B 2 16  ? 4.076  27.785 -36.827 1.000 16.923 ? 16  GLY FFF CA  1 ? 
ATOM   1667 C C   . GLY B 2 16  ? 5.404  27.432 -36.179 1.000 16.829 ? 16  GLY FFF C   1 ? 
ATOM   1668 O O   . GLY B 2 16  ? 6.443  27.369 -36.882 1.000 16.332 ? 16  GLY FFF O   1 ? 
ATOM   1669 N N   . SER B 2 17  ? 5.360  27.211 -34.868 1.000 16.078 ? 17  SER FFF N   1 ? 
ATOM   1670 C CA  . SER B 2 17  ? 6.547  27.001 -34.009 1.000 16.930 ? 17  SER FFF CA  1 ? 
ATOM   1671 C C   . SER B 2 17  ? 6.379  25.761 -33.138 1.000 16.528 ? 17  SER FFF C   1 ? 
ATOM   1672 O O   . SER B 2 17  ? 5.258  25.450 -32.689 1.000 17.721 ? 17  SER FFF O   1 ? 
ATOM   1673 C CB  . SER B 2 17  ? 6.810  28.204 -33.133 1.000 20.083 ? 17  SER FFF CB  1 ? 
ATOM   1674 O OG  . SER B 2 17  ? 7.096  29.349 -33.902 1.000 23.489 ? 17  SER FFF OG  1 ? 
ATOM   1675 N N   . LEU B 2 18  ? 7.494  25.100 -32.865 1.000 16.361 ? 18  LEU FFF N   1 ? 
ATOM   1676 C CA  . LEU B 2 18  ? 7.600  24.038 -31.848 1.000 16.811 ? 18  LEU FFF CA  1 ? 
ATOM   1677 C C   . LEU B 2 18  ? 8.875  24.307 -31.061 1.000 17.037 ? 18  LEU FFF C   1 ? 
ATOM   1678 O O   . LEU B 2 18  ? 9.753  25.011 -31.575 1.000 17.713 ? 18  LEU FFF O   1 ? 
ATOM   1679 C CB  . LEU B 2 18  ? 7.654  22.664 -32.514 1.000 17.516 ? 18  LEU FFF CB  1 ? 
ATOM   1680 C CG  . LEU B 2 18  ? 6.345  22.154 -33.107 1.000 18.664 ? 18  LEU FFF CG  1 ? 
ATOM   1681 C CD1 . LEU B 2 18  ? 6.616  20.918 -33.947 1.000 21.597 ? 18  LEU FFF CD1 1 ? 
ATOM   1682 C CD2 . LEU B 2 18  ? 5.333  21.837 -32.017 1.000 19.518 ? 18  LEU FFF CD2 1 ? 
ATOM   1683 N N   . ARG B 2 19  ? 8.962  23.748 -29.862 1.000 17.752 ? 19  ARG FFF N   1 ? 
ATOM   1684 C CA  . ARG B 2 19  ? 10.192 23.852 -29.042 1.000 17.281 ? 19  ARG FFF CA  1 ? 
ATOM   1685 C C   . ARG B 2 19  ? 10.491 22.473 -28.487 1.000 19.115 ? 19  ARG FFF C   1 ? 
ATOM   1686 O O   . ARG B 2 19  ? 9.607  21.900 -27.841 1.000 19.931 ? 19  ARG FFF O   1 ? 
ATOM   1687 C CB  . ARG B 2 19  ? 10.026 24.884 -27.925 1.000 18.238 ? 19  ARG FFF CB  1 ? 
ATOM   1688 C CG  . ARG B 2 19  ? 11.259 25.050 -27.050 1.000 21.968 ? 19  ARG FFF CG  1 ? 
ATOM   1689 C CD  . ARG B 2 19  ? 10.944 26.087 -25.990 1.000 25.717 ? 19  ARG FFF CD  1 ? 
ATOM   1690 N NE  . ARG B 2 19  ? 12.049 26.410 -25.103 1.000 30.803 ? 19  ARG FFF NE  1 ? 
ATOM   1691 C CZ  . ARG B 2 19  ? 13.038 27.262 -25.371 1.000 35.090 ? 19  ARG FFF CZ  1 ? 
ATOM   1692 N NH1 . ARG B 2 19  ? 13.109 27.875 -26.544 1.000 35.898 ? 19  ARG FFF NH1 1 ? 
ATOM   1693 N NH2 . ARG B 2 19  ? 13.974 27.480 -24.460 1.000 33.159 ? 19  ARG FFF NH2 1 ? 
ATOM   1694 N N   . LEU B 2 20  ? 11.681 21.959 -28.788 1.000 16.306 ? 20  LEU FFF N   1 ? 
ATOM   1695 C CA  . LEU B 2 20  ? 12.175 20.674 -28.254 1.000 16.972 ? 20  LEU FFF CA  1 ? 
ATOM   1696 C C   . LEU B 2 20  ? 13.073 20.984 -27.063 1.000 16.067 ? 20  LEU FFF C   1 ? 
ATOM   1697 O O   . LEU B 2 20  ? 13.808 21.980 -27.108 1.000 16.942 ? 20  LEU FFF O   1 ? 
ATOM   1698 C CB  . LEU B 2 20  ? 12.956 19.917 -29.324 1.000 16.846 ? 20  LEU FFF CB  1 ? 
ATOM   1699 C CG  . LEU B 2 20  ? 12.268 19.761 -30.677 1.000 19.102 ? 20  LEU FFF CG  1 ? 
ATOM   1700 C CD1 . LEU B 2 20  ? 13.069 18.808 -31.534 1.000 18.487 ? 20  LEU FFF CD1 1 ? 
ATOM   1701 C CD2 . LEU B 2 20  ? 10.832 19.282 -30.531 1.000 20.574 ? 20  LEU FFF CD2 1 ? 
ATOM   1702 N N   . SER B 2 21  ? 12.973 20.159 -26.032 1.000 17.026 ? 21  SER FFF N   1 ? 
ATOM   1703 C CA  . SER B 2 21  ? 13.818 20.231 -24.824 1.000 17.119 ? 21  SER FFF CA  1 ? 
ATOM   1704 C C   . SER B 2 21  ? 14.537 18.896 -24.694 1.000 16.732 ? 21  SER FFF C   1 ? 
ATOM   1705 O O   . SER B 2 21  ? 13.974 17.855 -25.078 1.000 17.484 ? 21  SER FFF O   1 ? 
ATOM   1706 C CB  . SER B 2 21  ? 13.003 20.539 -23.593 1.000 18.152 ? 21  SER FFF CB  1 ? 
ATOM   1707 O OG  . SER B 2 21  ? 12.327 21.770 -23.732 1.000 22.325 ? 21  SER FFF OG  1 ? 
ATOM   1708 N N   . CYS B 2 22  ? 15.750 18.916 -24.170 1.000 15.618 ? 22  CYS FFF N   1 ? 
ATOM   1709 C CA  . CYS B 2 22  ? 16.520 17.688 -23.916 1.000 16.934 ? 22  CYS FFF CA  1 ? 
ATOM   1710 C C   . CYS B 2 22  ? 17.232 17.841 -22.581 1.000 16.404 ? 22  CYS FFF C   1 ? 
ATOM   1711 O O   . CYS B 2 22  ? 18.157 18.662 -22.504 1.000 17.421 ? 22  CYS FFF O   1 ? 
ATOM   1712 C CB  . CYS B 2 22  ? 17.498 17.457 -25.051 1.000 17.147 ? 22  CYS FFF CB  1 ? 
ATOM   1713 S SG  . CYS B 2 22  ? 18.608 16.053 -24.787 1.000 21.245 ? 22  CYS FFF SG  1 ? 
ATOM   1714 N N   . ALA B 2 23  ? 16.746 17.119 -21.573 1.000 16.570 ? 23  ALA FFF N   1 ? 
ATOM   1715 C CA  . ALA B 2 23  ? 17.263 17.167 -20.194 1.000 18.332 ? 23  ALA FFF CA  1 ? 
ATOM   1716 C C   . ALA B 2 23  ? 18.355 16.111 -20.052 1.000 16.885 ? 23  ALA FFF C   1 ? 
ATOM   1717 O O   . ALA B 2 23  ? 18.092 14.928 -20.351 1.000 18.833 ? 23  ALA FFF O   1 ? 
ATOM   1718 C CB  . ALA B 2 23  ? 16.137 16.942 -19.225 1.000 17.539 ? 23  ALA FFF CB  1 ? 
ATOM   1719 N N   . VAL B 2 24  ? 19.537 16.532 -19.617 1.000 17.478 ? 24  VAL FFF N   1 ? 
ATOM   1720 C CA  . VAL B 2 24  ? 20.709 15.630 -19.453 1.000 16.376 ? 24  VAL FFF CA  1 ? 
ATOM   1721 C C   . VAL B 2 24  ? 20.850 15.263 -17.982 1.000 18.371 ? 24  VAL FFF C   1 ? 
ATOM   1722 O O   . VAL B 2 24  ? 20.822 16.175 -17.145 1.000 18.606 ? 24  VAL FFF O   1 ? 
ATOM   1723 C CB  . VAL B 2 24  ? 21.991 16.303 -19.964 1.000 18.044 ? 24  VAL FFF CB  1 ? 
ATOM   1724 C CG1 . VAL B 2 24  ? 23.216 15.450 -19.695 1.000 19.197 ? 24  VAL FFF CG1 1 ? 
ATOM   1725 C CG2 . VAL B 2 24  ? 21.867 16.632 -21.442 1.000 19.738 ? 24  VAL FFF CG2 1 ? 
ATOM   1726 N N   . SER B 2 25  ? 21.032 13.975 -17.705 1.000 18.682 ? 25  SER FFF N   1 ? 
ATOM   1727 C CA  . SER B 2 25  ? 21.390 13.473 -16.359 1.000 20.076 ? 25  SER FFF CA  1 ? 
ATOM   1728 C C   . SER B 2 25  ? 22.677 12.654 -16.461 1.000 20.899 ? 25  SER FFF C   1 ? 
ATOM   1729 O O   . SER B 2 25  ? 22.871 11.969 -17.485 1.000 21.255 ? 25  SER FFF O   1 ? 
ATOM   1730 C CB  . SER B 2 25  ? 20.251 12.690 -15.768 1.000 24.425 ? 25  SER FFF CB  1 ? 
ATOM   1731 O OG  . SER B 2 25  ? 20.075 11.472 -16.459 1.000 33.334 ? 25  SER FFF OG  1 ? 
ATOM   1732 N N   . GLY B 2 26  ? 23.552 12.769 -15.458 1.000 19.947 ? 26  GLY FFF N   1 ? 
ATOM   1733 C CA  . GLY B 2 26  ? 24.722 11.888 -15.296 1.000 22.319 ? 26  GLY FFF CA  1 ? 
ATOM   1734 C C   . GLY B 2 26  ? 25.980 12.414 -15.963 1.000 23.538 ? 26  GLY FFF C   1 ? 
ATOM   1735 O O   . GLY B 2 26  ? 26.998 11.699 -15.934 1.000 26.310 ? 26  GLY FFF O   1 ? 
ATOM   1736 N N   . ARG B 2 27  ? 25.933 13.615 -16.540 1.000 22.971 ? 27  ARG FFF N   1 ? 
ATOM   1737 C CA  . ARG B 2 27  ? 27.088 14.249 -17.223 1.000 22.731 ? 27  ARG FFF CA  1 ? 
ATOM   1738 C C   . ARG B 2 27  ? 26.795 15.733 -17.434 1.000 21.377 ? 27  ARG FFF C   1 ? 
ATOM   1739 O O   . ARG B 2 27  ? 25.606 16.094 -17.548 1.000 20.354 ? 27  ARG FFF O   1 ? 
ATOM   1740 C CB  . ARG B 2 27  ? 27.335 13.589 -18.586 1.000 26.559 ? 27  ARG FFF CB  1 ? 
ATOM   1741 C CG  . ARG B 2 27  ? 28.671 13.947 -19.217 1.000 32.877 ? 27  ARG FFF CG  1 ? 
ATOM   1742 C CD  . ARG B 2 27  ? 28.850 13.284 -20.565 1.000 26.938 ? 27  ARG FFF CD  1 ? 
ATOM   1743 N NE  . ARG B 2 27  ? 30.169 13.502 -21.150 1.000 30.158 ? 27  ARG FFF NE  1 ? 
ATOM   1744 C CZ  . ARG B 2 27  ? 31.244 12.756 -20.912 1.000 28.140 ? 27  ARG FFF CZ  1 ? 
ATOM   1745 N NH1 . ARG B 2 27  ? 31.197 11.762 -20.040 1.000 35.795 ? 27  ARG FFF NH1 1 ? 
ATOM   1746 N NH2 . ARG B 2 27  ? 32.386 13.034 -21.519 1.000 35.078 ? 27  ARG FFF NH2 1 ? 
ATOM   1747 N N   . THR B 2 28  ? 27.846 16.546 -17.516 1.000 21.343 ? 28  THR FFF N   1 ? 
ATOM   1748 C CA  . THR B 2 28  ? 27.804 17.915 -18.095 1.000 22.379 ? 28  THR FFF CA  1 ? 
ATOM   1749 C C   . THR B 2 28  ? 28.781 17.935 -19.273 1.000 22.122 ? 28  THR FFF C   1 ? 
ATOM   1750 O O   . THR B 2 28  ? 29.738 17.138 -19.256 1.000 26.835 ? 28  THR FFF O   1 ? 
ATOM   1751 C CB  . THR B 2 28  ? 28.086 18.981 -17.030 1.000 27.397 ? 28  THR FFF CB  1 ? 
ATOM   1752 O OG1 . THR B 2 28  ? 29.429 18.822 -16.569 1.000 32.867 ? 28  THR FFF OG1 1 ? 
ATOM   1753 C CG2 . THR B 2 28  ? 27.129 18.900 -15.862 1.000 27.960 ? 28  THR FFF CG2 1 ? 
ATOM   1754 N N   . PHE B 2 29  ? 28.542 18.767 -20.285 1.000 19.916 ? 29  PHE FFF N   1 ? 
ATOM   1755 C CA  . PHE B 2 29  ? 29.279 18.666 -21.572 1.000 19.626 ? 29  PHE FFF CA  1 ? 
ATOM   1756 C C   . PHE B 2 29  ? 30.436 19.673 -21.633 1.000 20.375 ? 29  PHE FFF C   1 ? 
ATOM   1757 O O   . PHE B 2 29  ? 31.138 19.657 -22.636 1.000 19.545 ? 29  PHE FFF O   1 ? 
ATOM   1758 C CB  . PHE B 2 29  ? 28.297 18.679 -22.750 1.000 19.820 ? 29  PHE FFF CB  1 ? 
ATOM   1759 C CG  . PHE B 2 29  ? 27.655 17.329 -22.939 1.000 18.508 ? 29  PHE FFF CG  1 ? 
ATOM   1760 C CD1 . PHE B 2 29  ? 28.328 16.323 -23.615 1.000 19.866 ? 29  PHE FFF CD1 1 ? 
ATOM   1761 C CD2 . PHE B 2 29  ? 26.433 17.025 -22.366 1.000 20.646 ? 29  PHE FFF CD2 1 ? 
ATOM   1762 C CE1 . PHE B 2 29  ? 27.781 15.055 -23.746 1.000 19.288 ? 29  PHE FFF CE1 1 ? 
ATOM   1763 C CE2 . PHE B 2 29  ? 25.879 15.762 -22.511 1.000 20.078 ? 29  PHE FFF CE2 1 ? 
ATOM   1764 C CZ  . PHE B 2 29  ? 26.558 14.775 -23.187 1.000 19.350 ? 29  PHE FFF CZ  1 ? 
ATOM   1765 N N   . SER B 2 30  ? 30.675 20.443 -20.568 1.000 21.757 ? 30  SER FFF N   1 ? 
ATOM   1766 C CA  . SER B 2 30  ? 31.877 21.298 -20.364 1.000 20.782 ? 30  SER FFF CA  1 ? 
ATOM   1767 C C   . SER B 2 30  ? 32.317 21.955 -21.680 1.000 19.609 ? 30  SER FFF C   1 ? 
ATOM   1768 O O   . SER B 2 30  ? 31.542 22.754 -22.226 1.000 19.516 ? 30  SER FFF O   1 ? 
ATOM   1769 C CB  . SER B 2 30  ? 33.002 20.518 -19.702 1.000 22.368 ? 30  SER FFF CB  1 ? 
ATOM   1770 O OG  . SER B 2 30  ? 33.461 19.468 -20.531 1.000 29.679 ? 30  SER FFF OG  1 ? 
ATOM   1771 N N   . THR B 2 31  ? 33.525 21.658 -22.160 1.000 17.114 ? 31  THR FFF N   1 ? 
ATOM   1772 C CA  . THR B 2 31  ? 34.160 22.363 -23.302 1.000 17.216 ? 31  THR FFF CA  1 ? 
ATOM   1773 C C   . THR B 2 31  ? 33.746 21.725 -24.631 1.000 16.816 ? 31  THR FFF C   1 ? 
ATOM   1774 O O   . THR B 2 31  ? 34.204 22.211 -25.687 1.000 16.290 ? 31  THR FFF O   1 ? 
ATOM   1775 C CB  . THR B 2 31  ? 35.683 22.356 -23.164 1.000 16.737 ? 31  THR FFF CB  1 ? 
ATOM   1776 O OG1 . THR B 2 31  ? 36.106 21.005 -22.974 1.000 18.172 ? 31  THR FFF OG1 1 ? 
ATOM   1777 C CG2 . THR B 2 31  ? 36.145 23.221 -22.012 1.000 18.687 ? 31  THR FFF CG2 1 ? 
ATOM   1778 N N   . ALA B 2 32  ? 32.908 20.690 -24.594 1.000 15.717 ? 32  ALA FFF N   1 ? 
ATOM   1779 C CA  . ALA B 2 32  ? 32.441 20.016 -25.820 1.000 15.641 ? 32  ALA FFF CA  1 ? 
ATOM   1780 C C   . ALA B 2 32  ? 31.107 20.651 -26.221 1.000 16.963 ? 32  ALA FFF C   1 ? 
ATOM   1781 O O   . ALA B 2 32  ? 30.910 21.863 -25.988 1.000 16.725 ? 32  ALA FFF O   1 ? 
ATOM   1782 C CB  . ALA B 2 32  ? 32.370 18.521 -25.603 1.000 16.361 ? 32  ALA FFF CB  1 ? 
ATOM   1783 N N   . ALA B 2 33  ? 30.211 19.878 -26.814 1.000 15.329 ? 33  ALA FFF N   1 ? 
ATOM   1784 C CA  . ALA B 2 33  ? 28.987 20.425 -27.424 1.000 15.648 ? 33  ALA FFF CA  1 ? 
ATOM   1785 C C   . ALA B 2 33  ? 27.824 19.446 -27.280 1.000 14.127 ? 33  ALA FFF C   1 ? 
ATOM   1786 O O   . ALA B 2 33  ? 28.049 18.219 -27.113 1.000 15.037 ? 33  ALA FFF O   1 ? 
ATOM   1787 C CB  . ALA B 2 33  ? 29.244 20.736 -28.877 1.000 15.708 ? 33  ALA FFF CB  1 ? 
ATOM   1788 N N   . MET B 2 34  ? 26.624 20.009 -27.336 1.000 14.522 ? 34  MET FFF N   1 ? 
ATOM   1789 C CA  A MET B 2 34  ? 25.354 19.280 -27.562 0.500 16.740 ? 34  MET FFF CA  1 ? 
ATOM   1790 C CA  B MET B 2 34  ? 25.402 19.221 -27.603 0.500 12.198 ? 34  MET FFF CA  1 ? 
ATOM   1791 C C   . MET B 2 34  ? 24.843 19.665 -28.953 1.000 14.874 ? 34  MET FFF C   1 ? 
ATOM   1792 O O   . MET B 2 34  ? 25.239 20.722 -29.452 1.000 16.242 ? 34  MET FFF O   1 ? 
ATOM   1793 C CB  A MET B 2 34  ? 24.303 19.653 -26.513 0.500 22.073 ? 34  MET FFF CB  1 ? 
ATOM   1794 C CB  B MET B 2 34  ? 24.354 19.384 -26.502 0.500 10.339 ? 34  MET FFF CB  1 ? 
ATOM   1795 C CG  A MET B 2 34  ? 24.762 19.440 -25.085 0.500 28.269 ? 34  MET FFF CG  1 ? 
ATOM   1796 C CG  B MET B 2 34  ? 24.825 18.867 -25.159 0.500 9.241  ? 34  MET FFF CG  1 ? 
ATOM   1797 S SD  A MET B 2 34  ? 24.246 17.846 -24.427 0.500 41.799 ? 34  MET FFF SD  1 ? 
ATOM   1798 S SD  B MET B 2 34  ? 23.441 18.682 -24.013 0.500 8.497  ? 34  MET FFF SD  1 ? 
ATOM   1799 C CE  A MET B 2 34  ? 22.469 18.053 -24.414 0.500 36.304 ? 34  MET FFF CE  1 ? 
ATOM   1800 C CE  B MET B 2 34  ? 22.727 17.172 -24.665 0.500 8.901  ? 34  MET FFF CE  1 ? 
ATOM   1801 N N   . GLY B 2 35  ? 23.998 18.841 -29.538 1.000 14.092 ? 35  GLY FFF N   1 ? 
ATOM   1802 C CA  . GLY B 2 35  ? 23.447 19.147 -30.859 1.000 13.716 ? 35  GLY FFF CA  1 ? 
ATOM   1803 C C   . GLY B 2 35  ? 22.086 18.543 -31.057 1.000 13.903 ? 35  GLY FFF C   1 ? 
ATOM   1804 O O   . GLY B 2 35  ? 21.604 17.792 -30.186 1.000 15.101 ? 35  GLY FFF O   1 ? 
ATOM   1805 N N   . TRP B 2 36  ? 21.479 18.895 -32.182 1.000 13.551 ? 36  TRP FFF N   1 ? 
ATOM   1806 C CA  . TRP B 2 36  ? 20.219 18.306 -32.671 1.000 13.641 ? 36  TRP FFF CA  1 ? 
ATOM   1807 C C   . TRP B 2 36  ? 20.470 17.749 -34.063 1.000 13.841 ? 36  TRP FFF C   1 ? 
ATOM   1808 O O   . TRP B 2 36  ? 21.217 18.368 -34.847 1.000 14.066 ? 36  TRP FFF O   1 ? 
ATOM   1809 C CB  . TRP B 2 36  ? 19.088 19.339 -32.677 1.000 14.059 ? 36  TRP FFF CB  1 ? 
ATOM   1810 C CG  . TRP B 2 36  ? 18.673 19.773 -31.312 1.000 14.520 ? 36  TRP FFF CG  1 ? 
ATOM   1811 C CD1 . TRP B 2 36  ? 19.154 20.843 -30.617 1.000 14.715 ? 36  TRP FFF CD1 1 ? 
ATOM   1812 C CD2 . TRP B 2 36  ? 17.706 19.136 -30.461 1.000 14.912 ? 36  TRP FFF CD2 1 ? 
ATOM   1813 N NE1 . TRP B 2 36  ? 18.547 20.912 -29.390 1.000 17.017 ? 36  TRP FFF NE1 1 ? 
ATOM   1814 C CE2 . TRP B 2 36  ? 17.661 19.882 -29.268 1.000 15.709 ? 36  TRP FFF CE2 1 ? 
ATOM   1815 C CE3 . TRP B 2 36  ? 16.879 18.017 -30.589 1.000 15.754 ? 36  TRP FFF CE3 1 ? 
ATOM   1816 C CZ2 . TRP B 2 36  ? 16.817 19.543 -28.210 1.000 15.891 ? 36  TRP FFF CZ2 1 ? 
ATOM   1817 C CZ3 . TRP B 2 36  ? 16.032 17.694 -29.554 1.000 16.853 ? 36  TRP FFF CZ3 1 ? 
ATOM   1818 C CH2 . TRP B 2 36  ? 16.012 18.443 -28.376 1.000 16.393 ? 36  TRP FFF CH2 1 ? 
ATOM   1819 N N   . PHE B 2 37  ? 19.863 16.604 -34.321 1.000 13.963 ? 37  PHE FFF N   1 ? 
ATOM   1820 C CA  . PHE B 2 37  ? 19.880 15.901 -35.616 1.000 13.876 ? 37  PHE FFF CA  1 ? 
ATOM   1821 C C   . PHE B 2 37  ? 18.441 15.592 -35.974 1.000 14.644 ? 37  PHE FFF C   1 ? 
ATOM   1822 O O   . PHE B 2 37  ? 17.587 15.560 -35.079 1.000 14.676 ? 37  PHE FFF O   1 ? 
ATOM   1823 C CB  . PHE B 2 37  ? 20.694 14.610 -35.512 1.000 14.007 ? 37  PHE FFF CB  1 ? 
ATOM   1824 C CG  . PHE B 2 37  ? 22.176 14.841 -35.381 1.000 15.247 ? 37  PHE FFF CG  1 ? 
ATOM   1825 C CD1 . PHE B 2 37  ? 22.732 15.229 -34.173 1.000 16.125 ? 37  PHE FFF CD1 1 ? 
ATOM   1826 C CD2 . PHE B 2 37  ? 23.005 14.701 -36.478 1.000 16.413 ? 37  PHE FFF CD2 1 ? 
ATOM   1827 C CE1 . PHE B 2 37  ? 24.093 15.465 -34.062 1.000 18.103 ? 37  PHE FFF CE1 1 ? 
ATOM   1828 C CE2 . PHE B 2 37  ? 24.366 14.940 -36.367 1.000 18.396 ? 37  PHE FFF CE2 1 ? 
ATOM   1829 C CZ  . PHE B 2 37  ? 24.905 15.322 -35.160 1.000 18.151 ? 37  PHE FFF CZ  1 ? 
ATOM   1830 N N   . ARG B 2 38  ? 18.206 15.277 -37.237 1.000 14.370 ? 38  ARG FFF N   1 ? 
ATOM   1831 C CA  . ARG B 2 38  ? 16.857 14.834 -37.652 1.000 14.608 ? 38  ARG FFF CA  1 ? 
ATOM   1832 C C   . ARG B 2 38  ? 16.995 13.770 -38.730 1.000 15.291 ? 38  ARG FFF C   1 ? 
ATOM   1833 O O   . ARG B 2 38  ? 17.981 13.779 -39.486 1.000 16.601 ? 38  ARG FFF O   1 ? 
ATOM   1834 C CB  . ARG B 2 38  ? 16.000 16.006 -38.131 1.000 14.548 ? 38  ARG FFF CB  1 ? 
ATOM   1835 C CG  . ARG B 2 38  ? 16.492 16.669 -39.405 1.000 14.912 ? 38  ARG FFF CG  1 ? 
ATOM   1836 C CD  . ARG B 2 38  ? 15.670 17.906 -39.678 1.000 16.772 ? 38  ARG FFF CD  1 ? 
ATOM   1837 N NE  . ARG B 2 38  ? 16.094 18.603 -40.874 1.000 18.447 ? 38  ARG FFF NE  1 ? 
ATOM   1838 C CZ  . ARG B 2 38  ? 15.542 19.727 -41.322 1.000 19.218 ? 38  ARG FFF CZ  1 ? 
ATOM   1839 N NH1 . ARG B 2 38  ? 14.556 20.296 -40.654 1.000 16.830 ? 38  ARG FFF NH1 1 ? 
ATOM   1840 N NH2 . ARG B 2 38  ? 15.989 20.283 -42.433 1.000 22.913 ? 38  ARG FFF NH2 1 ? 
ATOM   1841 N N   . GLN B 2 39  ? 16.000 12.897 -38.800 1.000 15.301 ? 39  GLN FFF N   1 ? 
ATOM   1842 C CA  . GLN B 2 39  ? 15.993 11.807 -39.792 1.000 16.122 ? 39  GLN FFF CA  1 ? 
ATOM   1843 C C   . GLN B 2 39  ? 14.588 11.696 -40.356 1.000 15.623 ? 39  GLN FFF C   1 ? 
ATOM   1844 O O   . GLN B 2 39  ? 13.665 11.380 -39.593 1.000 15.338 ? 39  GLN FFF O   1 ? 
ATOM   1845 C CB  . GLN B 2 39  ? 16.452 10.495 -39.171 1.000 18.134 ? 39  GLN FFF CB  1 ? 
ATOM   1846 C CG  . GLN B 2 39  ? 16.635 9.417  -40.231 1.000 20.937 ? 39  GLN FFF CG  1 ? 
ATOM   1847 C CD  . GLN B 2 39  ? 17.256 8.163  -39.675 1.000 27.451 ? 39  GLN FFF CD  1 ? 
ATOM   1848 O OE1 . GLN B 2 39  ? 17.044 7.811  -38.516 1.000 32.174 ? 39  GLN FFF OE1 1 ? 
ATOM   1849 N NE2 . GLN B 2 39  ? 18.014 7.468  -40.510 1.000 28.639 ? 39  GLN FFF NE2 1 ? 
ATOM   1850 N N   . ALA B 2 40  ? 14.450 11.997 -41.642 1.000 17.457 ? 40  ALA FFF N   1 ? 
ATOM   1851 C CA  . ALA B 2 40  ? 13.192 11.812 -42.385 1.000 18.509 ? 40  ALA FFF CA  1 ? 
ATOM   1852 C C   . ALA B 2 40  ? 13.219 10.430 -43.016 1.000 19.043 ? 40  ALA FFF C   1 ? 
ATOM   1853 O O   . ALA B 2 40  ? 14.282 9.855  -43.213 1.000 17.155 ? 40  ALA FFF O   1 ? 
ATOM   1854 C CB  . ALA B 2 40  ? 13.035 12.891 -43.422 1.000 19.840 ? 40  ALA FFF CB  1 ? 
ATOM   1855 N N   . PRO B 2 41  ? 12.050 9.851  -43.350 1.000 20.811 ? 41  PRO FFF N   1 ? 
ATOM   1856 C CA  . PRO B 2 41  ? 12.006 8.532  -43.975 1.000 21.153 ? 41  PRO FFF CA  1 ? 
ATOM   1857 C C   . PRO B 2 41  ? 12.873 8.445  -45.237 1.000 20.827 ? 41  PRO FFF C   1 ? 
ATOM   1858 O O   . PRO B 2 41  ? 12.887 9.363  -46.065 1.000 20.397 ? 41  PRO FFF O   1 ? 
ATOM   1859 C CB  . PRO B 2 41  ? 10.511 8.344  -44.274 1.000 21.573 ? 41  PRO FFF CB  1 ? 
ATOM   1860 C CG  . PRO B 2 41  ? 9.839  9.193  -43.222 1.000 21.404 ? 41  PRO FFF CG  1 ? 
ATOM   1861 C CD  . PRO B 2 41  ? 10.715 10.422 -43.130 1.000 22.577 ? 41  PRO FFF CD  1 ? 
ATOM   1862 N N   . GLY B 2 42  ? 13.620 7.348  -45.332 1.000 21.811 ? 42  GLY FFF N   1 ? 
ATOM   1863 C CA  . GLY B 2 42  ? 14.486 7.041  -46.479 1.000 20.942 ? 42  GLY FFF CA  1 ? 
ATOM   1864 C C   . GLY B 2 42  ? 15.775 7.836  -46.475 1.000 22.993 ? 42  GLY FFF C   1 ? 
ATOM   1865 O O   . GLY B 2 42  ? 16.611 7.587  -47.362 1.000 24.980 ? 42  GLY FFF O   1 ? 
ATOM   1866 N N   . LYS B 2 43  ? 15.964 8.749  -45.516 1.000 21.471 ? 43  LYS FFF N   1 ? 
ATOM   1867 C CA  . LYS B 2 43  ? 17.130 9.665  -45.514 1.000 22.840 ? 43  LYS FFF CA  1 ? 
ATOM   1868 C C   . LYS B 2 43  ? 18.079 9.318  -44.366 1.000 20.964 ? 43  LYS FFF C   1 ? 
ATOM   1869 O O   . LYS B 2 43  ? 17.655 8.698  -43.374 1.000 22.222 ? 43  LYS FFF O   1 ? 
ATOM   1870 C CB  . LYS B 2 43  ? 16.658 11.119 -45.500 1.000 23.867 ? 43  LYS FFF CB  1 ? 
ATOM   1871 C CG  . LYS B 2 43  ? 15.930 11.503 -46.783 1.000 28.434 ? 43  LYS FFF CG  1 ? 
ATOM   1872 C CD  . LYS B 2 43  ? 15.511 12.935 -46.874 1.000 28.781 ? 43  LYS FFF CD  1 ? 
ATOM   1873 C CE  . LYS B 2 43  ? 14.577 13.188 -48.038 1.000 32.161 ? 43  LYS FFF CE  1 ? 
ATOM   1874 N NZ  . LYS B 2 43  ? 15.290 13.775 -49.193 1.000 35.835 ? 43  LYS FFF NZ  1 ? 
ATOM   1875 N N   . GLU B 2 44  ? 19.338 9.701  -44.547 1.000 26.622 ? 44  GLU FFF N   1 ? 
ATOM   1876 C CA  . GLU B 2 44  ? 20.394 9.616  -43.514 1.000 30.218 ? 44  GLU FFF CA  1 ? 
ATOM   1877 C C   . GLU B 2 44  ? 20.050 10.621 -42.416 1.000 28.354 ? 44  GLU FFF C   1 ? 
ATOM   1878 O O   . GLU B 2 44  ? 19.448 11.665 -42.729 1.000 28.171 ? 44  GLU FFF O   1 ? 
ATOM   1879 C CB  . GLU B 2 44  ? 21.766 9.892  -44.137 1.000 33.431 ? 44  GLU FFF CB  1 ? 
ATOM   1880 C CG  . GLU B 2 44  ? 22.318 8.716  -44.920 1.000 43.776 ? 44  GLU FFF CG  1 ? 
ATOM   1881 C CD  . GLU B 2 44  ? 22.662 7.501  -44.074 1.000 55.573 ? 44  GLU FFF CD  1 ? 
ATOM   1882 O OE1 . GLU B 2 44  ? 23.340 7.673  -43.038 1.000 67.797 ? 44  GLU FFF OE1 1 ? 
ATOM   1883 O OE2 . GLU B 2 44  ? 22.244 6.386  -44.446 1.000 68.217 ? 44  GLU FFF OE2 1 ? 
ATOM   1884 N N   . ARG B 2 45  ? 20.380 10.288 -41.173 1.000 26.727 ? 45  ARG FFF N   1 ? 
ATOM   1885 C CA  . ARG B 2 45  ? 20.269 11.227 -40.034 1.000 25.913 ? 45  ARG FFF CA  1 ? 
ATOM   1886 C C   . ARG B 2 45  ? 21.154 12.434 -40.342 1.000 25.952 ? 45  ARG FFF C   1 ? 
ATOM   1887 O O   . ARG B 2 45  ? 22.341 12.218 -40.670 1.000 35.679 ? 45  ARG FFF O   1 ? 
ATOM   1888 C CB  . ARG B 2 45  ? 20.675 10.522 -38.742 1.000 27.905 ? 45  ARG FFF CB  1 ? 
ATOM   1889 C CG  . ARG B 2 45  ? 20.462 11.378 -37.507 1.000 27.787 ? 45  ARG FFF CG  1 ? 
ATOM   1890 C CD  . ARG B 2 45  ? 20.554 10.610 -36.213 1.000 30.978 ? 45  ARG FFF CD  1 ? 
ATOM   1891 N NE  . ARG B 2 45  ? 19.777 9.384  -36.194 1.000 35.049 ? 45  ARG FFF NE  1 ? 
ATOM   1892 C CZ  . ARG B 2 45  ? 19.699 8.569  -35.152 1.000 36.994 ? 45  ARG FFF CZ  1 ? 
ATOM   1893 N NH1 . ARG B 2 45  ? 20.354 8.854  -34.040 1.000 36.471 ? 45  ARG FFF NH1 1 ? 
ATOM   1894 N NH2 . ARG B 2 45  ? 18.968 7.470  -35.224 1.000 42.696 ? 45  ARG FFF NH2 1 ? 
ATOM   1895 N N   . GLU B 2 46  ? 20.606 13.651 -40.278 1.000 18.779 ? 46  GLU FFF N   1 ? 
ATOM   1896 C CA  . GLU B 2 46  ? 21.339 14.871 -40.694 1.000 19.172 ? 46  GLU FFF CA  1 ? 
ATOM   1897 C C   . GLU B 2 46  ? 21.459 15.861 -39.536 1.000 15.903 ? 46  GLU FFF C   1 ? 
ATOM   1898 O O   . GLU B 2 46  ? 20.541 16.007 -38.701 1.000 16.002 ? 46  GLU FFF O   1 ? 
ATOM   1899 C CB  . GLU B 2 46  ? 20.715 15.493 -41.938 1.000 23.285 ? 46  GLU FFF CB  1 ? 
ATOM   1900 C CG  . GLU B 2 46  ? 19.356 16.113 -41.727 1.000 24.735 ? 46  GLU FFF CG  1 ? 
ATOM   1901 C CD  . GLU B 2 46  ? 18.831 16.846 -42.955 1.000 35.312 ? 46  GLU FFF CD  1 ? 
ATOM   1902 O OE1 . GLU B 2 46  ? 17.987 17.754 -42.792 1.000 31.040 ? 46  GLU FFF OE1 1 ? 
ATOM   1903 O OE2 . GLU B 2 46  ? 19.269 16.509 -44.076 1.000 37.610 ? 46  GLU FFF OE2 1 ? 
ATOM   1904 N N   . PHE B 2 47  ? 22.605 16.516 -39.502 1.000 15.579 ? 47  PHE FFF N   1 ? 
ATOM   1905 C CA  . PHE B 2 47  ? 22.945 17.585 -38.544 1.000 14.518 ? 47  PHE FFF CA  1 ? 
ATOM   1906 C C   . PHE B 2 47  ? 21.970 18.755 -38.703 1.000 14.631 ? 47  PHE FFF C   1 ? 
ATOM   1907 O O   . PHE B 2 47  ? 21.678 19.186 -39.846 1.000 15.851 ? 47  PHE FFF O   1 ? 
ATOM   1908 C CB  . PHE B 2 47  ? 24.382 18.026 -38.800 1.000 15.252 ? 47  PHE FFF CB  1 ? 
ATOM   1909 C CG  . PHE B 2 47  ? 24.785 19.199 -37.954 1.000 14.958 ? 47  PHE FFF CG  1 ? 
ATOM   1910 C CD1 . PHE B 2 47  ? 25.045 19.022 -36.604 1.000 14.226 ? 47  PHE FFF CD1 1 ? 
ATOM   1911 C CD2 . PHE B 2 47  ? 24.882 20.468 -38.494 1.000 15.118 ? 47  PHE FFF CD2 1 ? 
ATOM   1912 C CE1 . PHE B 2 47  ? 25.402 20.100 -35.816 1.000 16.214 ? 47  PHE FFF CE1 1 ? 
ATOM   1913 C CE2 . PHE B 2 47  ? 25.235 21.544 -37.699 1.000 15.602 ? 47  PHE FFF CE2 1 ? 
ATOM   1914 C CZ  . PHE B 2 47  ? 25.495 21.354 -36.364 1.000 14.634 ? 47  PHE FFF CZ  1 ? 
ATOM   1915 N N   . VAL B 2 48  ? 21.486 19.273 -37.573 1.000 13.661 ? 48  VAL FFF N   1 ? 
ATOM   1916 C CA  . VAL B 2 48  ? 20.623 20.484 -37.517 1.000 13.979 ? 48  VAL FFF CA  1 ? 
ATOM   1917 C C   . VAL B 2 48  ? 21.383 21.643 -36.862 1.000 13.954 ? 48  VAL FFF C   1 ? 
ATOM   1918 O O   . VAL B 2 48  ? 21.468 22.716 -37.469 1.000 14.368 ? 48  VAL FFF O   1 ? 
ATOM   1919 C CB  . VAL B 2 48  ? 19.299 20.178 -36.794 1.000 14.159 ? 48  VAL FFF CB  1 ? 
ATOM   1920 C CG1 . VAL B 2 48  ? 18.469 21.437 -36.632 1.000 14.982 ? 48  VAL FFF CG1 1 ? 
ATOM   1921 C CG2 . VAL B 2 48  ? 18.504 19.106 -37.533 1.000 15.078 ? 48  VAL FFF CG2 1 ? 
ATOM   1922 N N   . ALA B 2 49  ? 21.897 21.463 -35.647 1.000 13.578 ? 49  ALA FFF N   1 ? 
ATOM   1923 C CA  . ALA B 2 49  ? 22.533 22.561 -34.889 1.000 13.503 ? 49  ALA FFF CA  1 ? 
ATOM   1924 C C   . ALA B 2 49  ? 23.405 21.985 -33.778 1.000 14.011 ? 49  ALA FFF C   1 ? 
ATOM   1925 O O   . ALA B 2 49  ? 23.154 20.851 -33.344 1.000 13.847 ? 49  ALA FFF O   1 ? 
ATOM   1926 C CB  . ALA B 2 49  ? 21.477 23.486 -34.339 1.000 13.875 ? 49  ALA FFF CB  1 ? 
ATOM   1927 N N   . ALA B 2 50  ? 24.438 22.725 -33.398 1.000 12.689 ? 50  ALA FFF N   1 ? 
ATOM   1928 C CA  . ALA B 2 50  ? 25.323 22.388 -32.268 1.000 13.067 ? 50  ALA FFF CA  1 ? 
ATOM   1929 C C   . ALA B 2 50  ? 25.524 23.632 -31.420 1.000 13.191 ? 50  ALA FFF C   1 ? 
ATOM   1930 O O   . ALA B 2 50  ? 25.497 24.750 -31.957 1.000 14.135 ? 50  ALA FFF O   1 ? 
ATOM   1931 C CB  . ALA B 2 50  ? 26.646 21.833 -32.737 1.000 13.492 ? 50  ALA FFF CB  1 ? 
ATOM   1932 N N   . ILE B 2 51  ? 25.811 23.412 -30.145 1.000 13.893 ? 51  ILE FFF N   1 ? 
ATOM   1933 C CA  . ILE B 2 51  ? 26.121 24.517 -29.207 1.000 14.659 ? 51  ILE FFF CA  1 ? 
ATOM   1934 C C   . ILE B 2 51  ? 27.299 24.106 -28.323 1.000 13.183 ? 51  ILE FFF C   1 ? 
ATOM   1935 O O   . ILE B 2 51  ? 27.271 23.004 -27.756 1.000 14.402 ? 51  ILE FFF O   1 ? 
ATOM   1936 C CB  . ILE B 2 51  ? 24.861 24.910 -28.417 1.000 12.998 ? 51  ILE FFF CB  1 ? 
ATOM   1937 C CG1 . ILE B 2 51  ? 25.103 26.157 -27.569 1.000 14.494 ? 51  ILE FFF CG1 1 ? 
ATOM   1938 C CG2 . ILE B 2 51  ? 24.311 23.759 -27.584 1.000 13.338 ? 51  ILE FFF CG2 1 ? 
ATOM   1939 C CD1 . ILE B 2 51  ? 23.831 26.857 -27.182 1.000 15.423 ? 51  ILE FFF CD1 1 ? 
ATOM   1940 N N   . ARG B 2 52  ? 28.283 24.994 -28.214 1.000 13.943 ? 52  ARG FFF N   1 ? 
ATOM   1941 C CA  . ARG B 2 52  ? 29.402 24.871 -27.251 1.000 14.516 ? 52  ARG FFF CA  1 ? 
ATOM   1942 C C   . ARG B 2 52  ? 28.796 24.944 -25.855 1.000 14.732 ? 52  ARG FFF C   1 ? 
ATOM   1943 O O   . ARG B 2 52  ? 28.116 25.930 -25.559 1.000 15.818 ? 52  ARG FFF O   1 ? 
ATOM   1944 C CB  . ARG B 2 52  ? 30.410 26.002 -27.467 1.000 15.039 ? 52  ARG FFF CB  1 ? 
ATOM   1945 C CG  . ARG B 2 52  ? 31.573 26.000 -26.485 1.000 15.950 ? 52  ARG FFF CG  1 ? 
ATOM   1946 C CD  . ARG B 2 52  ? 32.654 25.008 -26.844 1.000 15.563 ? 52  ARG FFF CD  1 ? 
ATOM   1947 N NE  . ARG B 2 52  ? 33.182 25.282 -28.172 1.000 14.833 ? 52  ARG FFF NE  1 ? 
ATOM   1948 C CZ  . ARG B 2 52  ? 33.942 24.447 -28.870 1.000 14.273 ? 52  ARG FFF CZ  1 ? 
ATOM   1949 N NH1 . ARG B 2 52  ? 34.313 23.285 -28.357 1.000 14.059 ? 52  ARG FFF NH1 1 ? 
ATOM   1950 N NH2 . ARG B 2 52  ? 34.337 24.782 -30.086 1.000 15.340 ? 52  ARG FFF NH2 1 ? 
ATOM   1951 N N   . TRP B 2 53  ? 28.996 23.922 -25.035 1.000 14.693 ? 53  TRP FFF N   1 ? 
ATOM   1952 C CA  . TRP B 2 53  ? 28.292 23.872 -23.737 1.000 15.615 ? 53  TRP FFF CA  1 ? 
ATOM   1953 C C   . TRP B 2 53  ? 28.766 25.025 -22.850 1.000 17.602 ? 53  TRP FFF C   1 ? 
ATOM   1954 O O   . TRP B 2 53  ? 27.912 25.762 -22.298 1.000 17.043 ? 53  TRP FFF O   1 ? 
ATOM   1955 C CB  . TRP B 2 53  ? 28.464 22.520 -23.054 1.000 16.354 ? 53  TRP FFF CB  1 ? 
ATOM   1956 C CG  . TRP B 2 53  ? 27.598 22.486 -21.843 1.000 17.708 ? 53  TRP FFF CG  1 ? 
ATOM   1957 C CD1 . TRP B 2 53  ? 27.967 22.722 -20.550 1.000 19.106 ? 53  TRP FFF CD1 1 ? 
ATOM   1958 C CD2 . TRP B 2 53  ? 26.172 22.340 -21.841 1.000 16.702 ? 53  TRP FFF CD2 1 ? 
ATOM   1959 N NE1 . TRP B 2 53  ? 26.866 22.689 -19.739 1.000 20.873 ? 53  TRP FFF NE1 1 ? 
ATOM   1960 C CE2 . TRP B 2 53  ? 25.753 22.445 -20.499 1.000 19.403 ? 53  TRP FFF CE2 1 ? 
ATOM   1961 C CE3 . TRP B 2 53  ? 25.219 22.109 -22.835 1.000 19.255 ? 53  TRP FFF CE3 1 ? 
ATOM   1962 C CZ2 . TRP B 2 53  ? 24.412 22.314 -20.134 1.000 20.435 ? 53  TRP FFF CZ2 1 ? 
ATOM   1963 C CZ3 . TRP B 2 53  ? 23.897 21.963 -22.469 1.000 19.048 ? 53  TRP FFF CZ3 1 ? 
ATOM   1964 C CH2 . TRP B 2 53  ? 23.503 22.073 -21.139 1.000 19.990 ? 53  TRP FFF CH2 1 ? 
ATOM   1965 N N   . SER B 2 54  ? 30.077 25.208 -22.718 1.000 16.788 ? 54  SER FFF N   1 ? 
ATOM   1966 C CA  . SER B 2 54  ? 30.637 26.208 -21.777 1.000 19.019 ? 54  SER FFF CA  1 ? 
ATOM   1967 C C   . SER B 2 54  ? 30.259 27.628 -22.230 1.000 19.351 ? 54  SER FFF C   1 ? 
ATOM   1968 O O   . SER B 2 54  ? 29.642 28.355 -21.442 1.000 22.261 ? 54  SER FFF O   1 ? 
ATOM   1969 C CB  . SER B 2 54  ? 32.122 26.035 -21.636 1.000 20.363 ? 54  SER FFF CB  1 ? 
ATOM   1970 O OG  . SER B 2 54  ? 32.760 26.095 -22.897 1.000 18.136 ? 54  SER FFF OG  1 ? 
ATOM   1971 N N   . GLY B 2 55  ? 30.590 28.010 -23.462 1.000 19.723 ? 55  GLY FFF N   1 ? 
ATOM   1972 C CA  . GLY B 2 55  ? 30.464 29.405 -23.932 1.000 18.565 ? 55  GLY FFF CA  1 ? 
ATOM   1973 C C   . GLY B 2 55  ? 29.159 29.711 -24.654 1.000 18.116 ? 55  GLY FFF C   1 ? 
ATOM   1974 O O   . GLY B 2 55  ? 28.823 30.903 -24.765 1.000 19.456 ? 55  GLY FFF O   1 ? 
ATOM   1975 N N   . GLY B 2 56  ? 28.461 28.705 -25.182 1.000 17.047 ? 56  GLY FFF N   1 ? 
ATOM   1976 C CA  . GLY B 2 56  ? 27.111 28.869 -25.763 1.000 17.510 ? 56  GLY FFF CA  1 ? 
ATOM   1977 C C   . GLY B 2 56  ? 27.088 29.309 -27.219 1.000 16.003 ? 56  GLY FFF C   1 ? 
ATOM   1978 O O   . GLY B 2 56  ? 25.984 29.563 -27.724 1.000 16.914 ? 56  GLY FFF O   1 ? 
ATOM   1979 N N   . SER B 2 57  ? 28.227 29.384 -27.909 1.000 15.573 ? 57  SER FFF N   1 ? 
ATOM   1980 C CA  . SER B 2 57  ? 28.256 29.681 -29.365 1.000 15.385 ? 57  SER FFF CA  1 ? 
ATOM   1981 C C   . SER B 2 57  ? 27.520 28.569 -30.116 1.000 15.446 ? 57  SER FFF C   1 ? 
ATOM   1982 O O   . SER B 2 57  ? 27.681 27.384 -29.748 1.000 14.696 ? 57  SER FFF O   1 ? 
ATOM   1983 C CB  . SER B 2 57  ? 29.656 29.848 -29.896 1.000 16.982 ? 57  SER FFF CB  1 ? 
ATOM   1984 O OG  . SER B 2 57  ? 30.285 31.004 -29.350 1.000 18.457 ? 57  SER FFF OG  1 ? 
ATOM   1985 N N   . ALA B 2 58  ? 26.786 28.932 -31.168 1.000 15.802 ? 58  ALA FFF N   1 ? 
ATOM   1986 C CA  . ALA B 2 58  ? 25.943 27.995 -31.940 1.000 15.090 ? 58  ALA FFF CA  1 ? 
ATOM   1987 C C   . ALA B 2 58  ? 26.433 27.882 -33.381 1.000 15.506 ? 58  ALA FFF C   1 ? 
ATOM   1988 O O   . ALA B 2 58  ? 26.991 28.859 -33.935 1.000 16.644 ? 58  ALA FFF O   1 ? 
ATOM   1989 C CB  . ALA B 2 58  ? 24.498 28.431 -31.894 1.000 16.689 ? 58  ALA FFF CB  1 ? 
ATOM   1990 N N   . TYR B 2 59  ? 26.220 26.703 -33.956 1.000 14.716 ? 59  TYR FFF N   1 ? 
ATOM   1991 C CA  . TYR B 2 59  ? 26.530 26.371 -35.364 1.000 15.429 ? 59  TYR FFF CA  1 ? 
ATOM   1992 C C   . TYR B 2 59  ? 25.299 25.699 -35.968 1.000 13.924 ? 59  TYR FFF C   1 ? 
ATOM   1993 O O   . TYR B 2 59  ? 24.705 24.819 -35.315 1.000 15.220 ? 59  TYR FFF O   1 ? 
ATOM   1994 C CB  . TYR B 2 59  ? 27.755 25.461 -35.466 1.000 14.725 ? 59  TYR FFF CB  1 ? 
ATOM   1995 C CG  . TYR B 2 59  ? 28.241 25.294 -36.882 1.000 15.673 ? 59  TYR FFF CG  1 ? 
ATOM   1996 C CD1 . TYR B 2 59  ? 29.018 26.276 -37.469 1.000 16.966 ? 59  TYR FFF CD1 1 ? 
ATOM   1997 C CD2 . TYR B 2 59  ? 27.881 24.202 -37.654 1.000 16.862 ? 59  TYR FFF CD2 1 ? 
ATOM   1998 C CE1 . TYR B 2 59  ? 29.465 26.160 -38.768 1.000 17.531 ? 59  TYR FFF CE1 1 ? 
ATOM   1999 C CE2 . TYR B 2 59  ? 28.318 24.074 -38.964 1.000 18.353 ? 59  TYR FFF CE2 1 ? 
ATOM   2000 C CZ  . TYR B 2 59  ? 29.115 25.058 -39.521 1.000 18.355 ? 59  TYR FFF CZ  1 ? 
ATOM   2001 O OH  . TYR B 2 59  ? 29.569 24.978 -40.804 1.000 25.140 ? 59  TYR FFF OH  1 ? 
ATOM   2002 N N   . TYR B 2 60  ? 24.907 26.114 -37.168 1.000 14.631 ? 60  TYR FFF N   1 ? 
ATOM   2003 C CA  . TYR B 2 60  ? 23.637 25.682 -37.798 1.000 14.316 ? 60  TYR FFF CA  1 ? 
ATOM   2004 C C   . TYR B 2 60  ? 23.880 25.087 -39.181 1.000 15.745 ? 60  TYR FFF C   1 ? 
ATOM   2005 O O   . TYR B 2 60  ? 24.702 25.635 -39.946 1.000 16.256 ? 60  TYR FFF O   1 ? 
ATOM   2006 C CB  . TYR B 2 60  ? 22.689 26.870 -37.943 1.000 13.997 ? 60  TYR FFF CB  1 ? 
ATOM   2007 C CG  . TYR B 2 60  ? 22.227 27.415 -36.622 1.000 14.351 ? 60  TYR FFF CG  1 ? 
ATOM   2008 C CD1 . TYR B 2 60  ? 21.184 26.822 -35.934 1.000 14.358 ? 60  TYR FFF CD1 1 ? 
ATOM   2009 C CD2 . TYR B 2 60  ? 22.877 28.480 -36.026 1.000 14.632 ? 60  TYR FFF CD2 1 ? 
ATOM   2010 C CE1 . TYR B 2 60  ? 20.766 27.294 -34.701 1.000 14.353 ? 60  TYR FFF CE1 1 ? 
ATOM   2011 C CE2 . TYR B 2 60  ? 22.474 28.963 -34.793 1.000 14.390 ? 60  TYR FFF CE2 1 ? 
ATOM   2012 C CZ  . TYR B 2 60  ? 21.414 28.373 -34.126 1.000 15.282 ? 60  TYR FFF CZ  1 ? 
ATOM   2013 O OH  . TYR B 2 60  ? 21.019 28.851 -32.908 1.000 15.698 ? 60  TYR FFF OH  1 ? 
ATOM   2014 N N   . ALA B 2 61  ? 23.111 24.051 -39.513 1.000 15.390 ? 61  ALA FFF N   1 ? 
ATOM   2015 C CA  . ALA B 2 61  ? 22.908 23.598 -40.903 1.000 16.350 ? 61  ALA FFF CA  1 ? 
ATOM   2016 C C   . ALA B 2 61  ? 22.294 24.757 -41.689 1.000 16.199 ? 61  ALA FFF C   1 ? 
ATOM   2017 O O   . ALA B 2 61  ? 21.415 25.467 -41.159 1.000 15.917 ? 61  ALA FFF O   1 ? 
ATOM   2018 C CB  . ALA B 2 61  ? 22.023 22.377 -40.933 1.000 15.909 ? 61  ALA FFF CB  1 ? 
ATOM   2019 N N   . ASP B 2 62  ? 22.727 24.933 -42.935 1.000 17.676 ? 62  ASP FFF N   1 ? 
ATOM   2020 C CA  . ASP B 2 62  ? 22.197 26.000 -43.823 1.000 19.578 ? 62  ASP FFF CA  1 ? 
ATOM   2021 C C   . ASP B 2 62  ? 20.670 25.899 -43.922 1.000 18.711 ? 62  ASP FFF C   1 ? 
ATOM   2022 O O   . ASP B 2 62  ? 20.022 26.948 -43.979 1.000 20.813 ? 62  ASP FFF O   1 ? 
ATOM   2023 C CB  . ASP B 2 62  ? 22.820 25.905 -45.217 1.000 21.559 ? 62  ASP FFF CB  1 ? 
ATOM   2024 C CG  . ASP B 2 62  ? 24.322 26.132 -45.238 1.000 30.797 ? 62  ASP FFF CG  1 ? 
ATOM   2025 O OD1 . ASP B 2 62  ? 24.839 26.721 -44.265 1.000 30.184 ? 62  ASP FFF OD1 1 ? 
ATOM   2026 O OD2 . ASP B 2 62  ? 24.964 25.718 -46.236 1.000 32.706 ? 62  ASP FFF OD2 1 ? 
ATOM   2027 N N   . SER B 2 63  ? 20.125 24.684 -43.923 1.000 18.770 ? 63  SER FFF N   1 ? 
ATOM   2028 C CA  . SER B 2 63  ? 18.682 24.399 -44.156 1.000 18.885 ? 63  SER FFF CA  1 ? 
ATOM   2029 C C   . SER B 2 63  ? 17.784 24.988 -43.053 1.000 18.834 ? 63  SER FFF C   1 ? 
ATOM   2030 O O   . SER B 2 63  ? 16.561 25.069 -43.292 1.000 19.796 ? 63  SER FFF O   1 ? 
ATOM   2031 C CB  . SER B 2 63  ? 18.462 22.920 -44.277 1.000 21.759 ? 63  SER FFF CB  1 ? 
ATOM   2032 O OG  . SER B 2 63  ? 18.867 22.269 -43.088 1.000 24.553 ? 63  SER FFF OG  1 ? 
ATOM   2033 N N   . VAL B 2 64  ? 18.322 25.380 -41.891 1.000 16.304 ? 64  VAL FFF N   1 ? 
ATOM   2034 C CA  . VAL B 2 64  ? 17.489 25.880 -40.757 1.000 16.539 ? 64  VAL FFF CA  1 ? 
ATOM   2035 C C   . VAL B 2 64  ? 17.917 27.292 -40.330 1.000 16.767 ? 64  VAL FFF C   1 ? 
ATOM   2036 O O   . VAL B 2 64  ? 17.309 27.819 -39.389 1.000 16.320 ? 64  VAL FFF O   1 ? 
ATOM   2037 C CB  . VAL B 2 64  ? 17.519 24.893 -39.573 1.000 15.945 ? 64  VAL FFF CB  1 ? 
ATOM   2038 C CG1 . VAL B 2 64  ? 17.115 23.492 -40.001 1.000 16.227 ? 64  VAL FFF CG1 1 ? 
ATOM   2039 C CG2 . VAL B 2 64  ? 18.872 24.880 -38.886 1.000 15.758 ? 64  VAL FFF CG2 1 ? 
ATOM   2040 N N   . LYS B 2 65  ? 18.891 27.918 -40.999 1.000 17.793 ? 65  LYS FFF N   1 ? 
ATOM   2041 C CA  . LYS B 2 65  ? 19.335 29.283 -40.608 1.000 19.551 ? 65  LYS FFF CA  1 ? 
ATOM   2042 C C   . LYS B 2 65  ? 18.177 30.275 -40.752 1.000 19.619 ? 65  LYS FFF C   1 ? 
ATOM   2043 O O   . LYS B 2 65  ? 17.418 30.194 -41.748 1.000 21.627 ? 65  LYS FFF O   1 ? 
ATOM   2044 C CB  . LYS B 2 65  ? 20.549 29.719 -41.423 1.000 20.962 ? 65  LYS FFF CB  1 ? 
ATOM   2045 C CG  . LYS B 2 65  ? 21.818 28.956 -41.092 1.000 20.151 ? 65  LYS FFF CG  1 ? 
ATOM   2046 C CD  . LYS B 2 65  ? 22.992 29.371 -41.938 1.000 22.159 ? 65  LYS FFF CD  1 ? 
ATOM   2047 C CE  . LYS B 2 65  ? 24.266 28.665 -41.543 1.000 24.797 ? 65  LYS FFF CE  1 ? 
ATOM   2048 N NZ  . LYS B 2 65  ? 25.387 29.052 -42.429 1.000 24.901 ? 65  LYS FFF NZ  1 ? 
ATOM   2049 N N   . GLY B 2 66  ? 18.053 31.166 -39.771 1.000 21.505 ? 66  GLY FFF N   1 ? 
ATOM   2050 C CA  . GLY B 2 66  ? 16.984 32.177 -39.700 1.000 20.543 ? 66  GLY FFF CA  1 ? 
ATOM   2051 C C   . GLY B 2 66  ? 15.651 31.601 -39.243 1.000 23.382 ? 66  GLY FFF C   1 ? 
ATOM   2052 O O   . GLY B 2 66  ? 14.674 32.368 -39.192 1.000 25.641 ? 66  GLY FFF O   1 ? 
ATOM   2053 N N   . ARG B 2 67  ? 15.580 30.308 -38.913 1.000 17.565 ? 67  ARG FFF N   1 ? 
ATOM   2054 C CA  . ARG B 2 67  ? 14.310 29.663 -38.497 1.000 17.492 ? 67  ARG FFF CA  1 ? 
ATOM   2055 C C   . ARG B 2 67  ? 14.478 28.952 -37.152 1.000 17.024 ? 67  ARG FFF C   1 ? 
ATOM   2056 O O   . ARG B 2 67  ? 13.586 29.067 -36.287 1.000 16.218 ? 67  ARG FFF O   1 ? 
ATOM   2057 C CB  . ARG B 2 67  ? 13.834 28.693 -39.581 1.000 17.710 ? 67  ARG FFF CB  1 ? 
ATOM   2058 C CG  . ARG B 2 67  ? 13.675 29.348 -40.944 1.000 19.218 ? 67  ARG FFF CG  1 ? 
ATOM   2059 C CD  . ARG B 2 67  ? 12.960 28.471 -41.950 1.000 19.058 ? 67  ARG FFF CD  1 ? 
ATOM   2060 N NE  . ARG B 2 67  ? 13.643 27.196 -42.137 1.000 17.639 ? 67  ARG FFF NE  1 ? 
ATOM   2061 C CZ  . ARG B 2 67  ? 13.173 25.998 -41.787 1.000 16.154 ? 67  ARG FFF CZ  1 ? 
ATOM   2062 N NH1 . ARG B 2 67  ? 11.989 25.874 -41.217 1.000 15.792 ? 67  ARG FFF NH1 1 ? 
ATOM   2063 N NH2 . ARG B 2 67  ? 13.907 24.921 -42.004 1.000 17.217 ? 67  ARG FFF NH2 1 ? 
ATOM   2064 N N   . PHE B 2 68  ? 15.544 28.172 -36.986 1.000 15.699 ? 68  PHE FFF N   1 ? 
ATOM   2065 C CA  . PHE B 2 68  ? 15.760 27.378 -35.759 1.000 15.714 ? 68  PHE FFF CA  1 ? 
ATOM   2066 C C   . PHE B 2 68  ? 16.839 28.042 -34.910 1.000 14.425 ? 68  PHE FFF C   1 ? 
ATOM   2067 O O   . PHE B 2 68  ? 17.804 28.595 -35.453 1.000 16.665 ? 68  PHE FFF O   1 ? 
ATOM   2068 C CB  . PHE B 2 68  ? 16.173 25.946 -36.097 1.000 16.594 ? 68  PHE FFF CB  1 ? 
ATOM   2069 C CG  . PHE B 2 68  ? 15.125 25.083 -36.749 1.000 16.047 ? 68  PHE FFF CG  1 ? 
ATOM   2070 C CD1 . PHE B 2 68  ? 13.921 25.590 -37.231 1.000 15.979 ? 68  PHE FFF CD1 1 ? 
ATOM   2071 C CD2 . PHE B 2 68  ? 15.381 23.733 -36.929 1.000 16.811 ? 68  PHE FFF CD2 1 ? 
ATOM   2072 C CE1 . PHE B 2 68  ? 12.995 24.759 -37.846 1.000 16.773 ? 68  PHE FFF CE1 1 ? 
ATOM   2073 C CE2 . PHE B 2 68  ? 14.460 22.908 -37.555 1.000 18.410 ? 68  PHE FFF CE2 1 ? 
ATOM   2074 C CZ  . PHE B 2 68  ? 13.267 23.420 -38.014 1.000 16.188 ? 68  PHE FFF CZ  1 ? 
ATOM   2075 N N   . THR B 2 69  ? 16.689 27.943 -33.597 1.000 15.387 ? 69  THR FFF N   1 ? 
ATOM   2076 C CA  . THR B 2 69  ? 17.677 28.457 -32.625 1.000 15.434 ? 69  THR FFF CA  1 ? 
ATOM   2077 C C   . THR B 2 69  ? 17.977 27.367 -31.605 1.000 15.015 ? 69  THR FFF C   1 ? 
ATOM   2078 O O   . THR B 2 69  ? 17.038 26.855 -30.984 1.000 14.909 ? 69  THR FFF O   1 ? 
ATOM   2079 C CB  . THR B 2 69  ? 17.178 29.718 -31.918 1.000 16.610 ? 69  THR FFF CB  1 ? 
ATOM   2080 O OG1 . THR B 2 69  ? 16.860 30.705 -32.904 1.000 19.301 ? 69  THR FFF OG1 1 ? 
ATOM   2081 C CG2 . THR B 2 69  ? 18.204 30.253 -30.942 1.000 18.848 ? 69  THR FFF CG2 1 ? 
ATOM   2082 N N   . ILE B 2 70  ? 19.253 27.051 -31.421 1.000 14.614 ? 70  ILE FFF N   1 ? 
ATOM   2083 C CA  . ILE B 2 70  ? 19.700 26.143 -30.335 1.000 14.709 ? 70  ILE FFF CA  1 ? 
ATOM   2084 C C   . ILE B 2 70  ? 20.138 27.004 -29.152 1.000 13.981 ? 70  ILE FFF C   1 ? 
ATOM   2085 O O   . ILE B 2 70  ? 20.745 28.074 -29.347 1.000 16.059 ? 70  ILE FFF O   1 ? 
ATOM   2086 C CB  . ILE B 2 70  ? 20.809 25.182 -30.810 1.000 14.930 ? 70  ILE FFF CB  1 ? 
ATOM   2087 C CG1 . ILE B 2 70  ? 21.088 24.103 -29.763 1.000 14.799 ? 70  ILE FFF CG1 1 ? 
ATOM   2088 C CG2 . ILE B 2 70  ? 22.079 25.920 -31.205 1.000 14.536 ? 70  ILE FFF CG2 1 ? 
ATOM   2089 C CD1 . ILE B 2 70  ? 21.997 23.007 -30.253 1.000 14.901 ? 70  ILE FFF CD1 1 ? 
ATOM   2090 N N   . SER B 2 71  ? 19.793 26.569 -27.952 1.000 14.418 ? 71  SER FFF N   1 ? 
ATOM   2091 C CA  . SER B 2 71  ? 20.153 27.280 -26.706 1.000 15.357 ? 71  SER FFF CA  1 ? 
ATOM   2092 C C   . SER B 2 71  ? 20.314 26.245 -25.598 1.000 16.547 ? 71  SER FFF C   1 ? 
ATOM   2093 O O   . SER B 2 71  ? 19.901 25.079 -25.779 1.000 14.789 ? 71  SER FFF O   1 ? 
ATOM   2094 C CB  . SER B 2 71  ? 19.132 28.343 -26.373 1.000 16.760 ? 71  SER FFF CB  1 ? 
ATOM   2095 O OG  . SER B 2 71  ? 17.876 27.774 -26.044 1.000 17.977 ? 71  SER FFF OG  1 ? 
ATOM   2096 N N   . ARG B 2 72  ? 20.900 26.637 -24.476 1.000 15.875 ? 72  ARG FFF N   1 ? 
ATOM   2097 C CA  . ARG B 2 72  ? 21.037 25.692 -23.349 1.000 16.724 ? 72  ARG FFF CA  1 ? 
ATOM   2098 C C   . ARG B 2 72  ? 21.002 26.465 -22.038 1.000 17.751 ? 72  ARG FFF C   1 ? 
ATOM   2099 O O   . ARG B 2 72  ? 21.390 27.643 -22.024 1.000 17.559 ? 72  ARG FFF O   1 ? 
ATOM   2100 C CB  . ARG B 2 72  ? 22.312 24.851 -23.475 1.000 16.829 ? 72  ARG FFF CB  1 ? 
ATOM   2101 C CG  . ARG B 2 72  ? 23.604 25.649 -23.525 1.000 17.445 ? 72  ARG FFF CG  1 ? 
ATOM   2102 C CD  . ARG B 2 72  ? 24.187 25.841 -22.142 1.000 19.136 ? 72  ARG FFF CD  1 ? 
ATOM   2103 N NE  . ARG B 2 72  ? 25.404 26.637 -22.183 1.000 20.751 ? 72  ARG FFF NE  1 ? 
ATOM   2104 C CZ  . ARG B 2 72  ? 25.467 27.964 -22.256 1.000 18.717 ? 72  ARG FFF CZ  1 ? 
ATOM   2105 N NH1 . ARG B 2 72  ? 24.366 28.696 -22.294 1.000 21.140 ? 72  ARG FFF NH1 1 ? 
ATOM   2106 N NH2 . ARG B 2 72  ? 26.644 28.560 -22.281 1.000 18.723 ? 72  ARG FFF NH2 1 ? 
ATOM   2107 N N   . ASP B 2 73  ? 20.539 25.782 -20.997 1.000 17.619 ? 73  ASP FFF N   1 ? 
ATOM   2108 C CA  . ASP B 2 73  ? 20.459 26.284 -19.606 1.000 18.736 ? 73  ASP FFF CA  1 ? 
ATOM   2109 C C   . ASP B 2 73  ? 21.354 25.378 -18.764 1.000 20.333 ? 73  ASP FFF C   1 ? 
ATOM   2110 O O   . ASP B 2 73  ? 20.995 24.210 -18.565 1.000 19.214 ? 73  ASP FFF O   1 ? 
ATOM   2111 C CB  . ASP B 2 73  ? 19.004 26.309 -19.154 1.000 18.977 ? 73  ASP FFF CB  1 ? 
ATOM   2112 C CG  . ASP B 2 73  ? 18.784 26.917 -17.781 1.000 24.933 ? 73  ASP FFF CG  1 ? 
ATOM   2113 O OD1 . ASP B 2 73  ? 19.655 26.733 -16.916 1.000 26.635 ? 73  ASP FFF OD1 1 ? 
ATOM   2114 O OD2 . ASP B 2 73  ? 17.722 27.542 -17.592 1.000 30.640 ? 73  ASP FFF OD2 1 ? 
ATOM   2115 N N   . LYS B 2 74  ? 22.516 25.877 -18.352 1.000 19.266 ? 74  LYS FFF N   1 ? 
ATOM   2116 C CA  . LYS B 2 74  ? 23.486 25.078 -17.569 1.000 21.852 ? 74  LYS FFF CA  1 ? 
ATOM   2117 C C   . LYS B 2 74  ? 22.856 24.619 -16.256 1.000 22.104 ? 74  LYS FFF C   1 ? 
ATOM   2118 O O   . LYS B 2 74  ? 23.090 23.466 -15.875 1.000 21.990 ? 74  LYS FFF O   1 ? 
ATOM   2119 C CB  . LYS B 2 74  ? 24.738 25.891 -17.262 1.000 24.124 ? 74  LYS FFF CB  1 ? 
ATOM   2120 C CG  . LYS B 2 74  ? 25.532 26.294 -18.484 1.000 24.280 ? 74  LYS FFF CG  1 ? 
ATOM   2121 C CD  . LYS B 2 74  ? 26.871 26.834 -18.088 1.000 26.503 ? 74  LYS FFF CD  1 ? 
ATOM   2122 C CE  . LYS B 2 74  ? 27.583 27.477 -19.247 1.000 26.209 ? 74  LYS FFF CE  1 ? 
ATOM   2123 N NZ  . LYS B 2 74  ? 28.866 28.068 -18.814 1.000 28.249 ? 74  LYS FFF NZ  1 ? 
ATOM   2124 N N   . ALA B 2 75  ? 22.132 25.506 -15.572 1.000 24.383 ? 75  ALA FFF N   1 ? 
ATOM   2125 C CA  . ALA B 2 75  ? 21.532 25.231 -14.246 1.000 26.859 ? 75  ALA FFF CA  1 ? 
ATOM   2126 C C   . ALA B 2 75  ? 20.553 24.056 -14.352 1.000 25.490 ? 75  ALA FFF C   1 ? 
ATOM   2127 O O   . ALA B 2 75  ? 20.540 23.207 -13.437 1.000 27.332 ? 75  ALA FFF O   1 ? 
ATOM   2128 C CB  . ALA B 2 75  ? 20.860 26.471 -13.711 1.000 25.439 ? 75  ALA FFF CB  1 ? 
ATOM   2129 N N   . LYS B 2 76  ? 19.782 23.983 -15.442 1.000 21.047 ? 76  LYS FFF N   1 ? 
ATOM   2130 C CA  . LYS B 2 76  ? 18.790 22.904 -15.683 1.000 21.523 ? 76  LYS FFF CA  1 ? 
ATOM   2131 C C   . LYS B 2 76  ? 19.440 21.741 -16.447 1.000 18.317 ? 76  LYS FFF C   1 ? 
ATOM   2132 O O   . LYS B 2 76  ? 18.737 20.754 -16.685 1.000 20.487 ? 76  LYS FFF O   1 ? 
ATOM   2133 C CB  . LYS B 2 76  ? 17.593 23.441 -16.469 1.000 25.119 ? 76  LYS FFF CB  1 ? 
ATOM   2134 C CG  . LYS B 2 76  ? 16.820 24.555 -15.779 1.000 30.786 ? 76  LYS FFF CG  1 ? 
ATOM   2135 C CD  . LYS B 2 76  ? 15.536 24.907 -16.496 1.000 32.546 ? 76  LYS FFF CD  1 ? 
ATOM   2136 C CE  . LYS B 2 76  ? 14.768 26.028 -15.830 1.000 44.072 ? 76  LYS FFF CE  1 ? 
ATOM   2137 N NZ  . LYS B 2 76  ? 14.280 25.628 -14.489 1.000 47.180 ? 76  LYS FFF NZ  1 ? 
ATOM   2138 N N   . ASN B 2 77  ? 20.702 21.886 -16.864 1.000 18.196 ? 77  ASN FFF N   1 ? 
ATOM   2139 C CA  . ASN B 2 77  ? 21.455 20.888 -17.671 1.000 17.117 ? 77  ASN FFF CA  1 ? 
ATOM   2140 C C   . ASN B 2 77  ? 20.576 20.451 -18.851 1.000 16.653 ? 77  ASN FFF C   1 ? 
ATOM   2141 O O   . ASN B 2 77  ? 20.428 19.232 -19.090 1.000 17.226 ? 77  ASN FFF O   1 ? 
ATOM   2142 C CB  . ASN B 2 77  ? 21.905 19.687 -16.831 1.000 17.565 ? 77  ASN FFF CB  1 ? 
ATOM   2143 C CG  . ASN B 2 77  ? 23.208 19.082 -17.319 1.000 18.382 ? 77  ASN FFF CG  1 ? 
ATOM   2144 O OD1 . ASN B 2 77  ? 24.075 19.790 -17.841 1.000 21.603 ? 77  ASN FFF OD1 1 ? 
ATOM   2145 N ND2 . ASN B 2 77  ? 23.374 17.782 -17.128 1.000 19.680 ? 77  ASN FFF ND2 1 ? 
ATOM   2146 N N   . THR B 2 78  ? 20.006 21.420 -19.558 1.000 18.013 ? 78  THR FFF N   1 ? 
ATOM   2147 C CA  . THR B 2 78  ? 19.019 21.180 -20.638 1.000 17.850 ? 78  THR FFF CA  1 ? 
ATOM   2148 C C   . THR B 2 78  ? 19.433 21.945 -21.892 1.000 16.421 ? 78  THR FFF C   1 ? 
ATOM   2149 O O   . THR B 2 78  ? 19.920 23.096 -21.785 1.000 17.005 ? 78  THR FFF O   1 ? 
ATOM   2150 C CB  . THR B 2 78  ? 17.603 21.550 -20.182 1.000 19.533 ? 78  THR FFF CB  1 ? 
ATOM   2151 O OG1 . THR B 2 78  ? 17.250 20.703 -19.088 1.000 19.588 ? 78  THR FFF OG1 1 ? 
ATOM   2152 C CG2 . THR B 2 78  ? 16.566 21.392 -21.272 1.000 20.633 ? 78  THR FFF CG2 1 ? 
ATOM   2153 N N   . VAL B 2 79  ? 19.263 21.304 -23.048 1.000 14.963 ? 79  VAL FFF N   1 ? 
ATOM   2154 C CA  . VAL B 2 79  ? 19.462 21.955 -24.372 1.000 15.606 ? 79  VAL FFF CA  1 ? 
ATOM   2155 C C   . VAL B 2 79  ? 18.097 22.036 -25.060 1.000 13.975 ? 79  VAL FFF C   1 ? 
ATOM   2156 O O   . VAL B 2 79  ? 17.247 21.158 -24.851 1.000 15.409 ? 79  VAL FFF O   1 ? 
ATOM   2157 C CB  . VAL B 2 79  ? 20.527 21.237 -25.227 1.000 15.586 ? 79  VAL FFF CB  1 ? 
ATOM   2158 C CG1 . VAL B 2 79  ? 20.106 19.844 -25.655 1.000 17.319 ? 79  VAL FFF CG1 1 ? 
ATOM   2159 C CG2 . VAL B 2 79  ? 20.942 22.057 -26.439 1.000 16.791 ? 79  VAL FFF CG2 1 ? 
ATOM   2160 N N   . TYR B 2 80  ? 17.923 23.077 -25.862 1.000 14.154 ? 80  TYR FFF N   1 ? 
ATOM   2161 C CA  . TYR B 2 80  ? 16.634 23.417 -26.494 1.000 14.387 ? 80  TYR FFF CA  1 ? 
ATOM   2162 C C   . TYR B 2 80  ? 16.827 23.601 -27.994 1.000 13.790 ? 80  TYR FFF C   1 ? 
ATOM   2163 O O   . TYR B 2 80  ? 17.880 24.089 -28.424 1.000 15.228 ? 80  TYR FFF O   1 ? 
ATOM   2164 C CB  . TYR B 2 80  ? 16.069 24.705 -25.908 1.000 16.559 ? 80  TYR FFF CB  1 ? 
ATOM   2165 C CG  . TYR B 2 80  ? 15.880 24.676 -24.418 1.000 16.235 ? 80  TYR FFF CG  1 ? 
ATOM   2166 C CD1 . TYR B 2 80  ? 14.767 24.090 -23.845 1.000 18.051 ? 80  TYR FFF CD1 1 ? 
ATOM   2167 C CD2 . TYR B 2 80  ? 16.829 25.239 -23.584 1.000 19.002 ? 80  TYR FFF CD2 1 ? 
ATOM   2168 C CE1 . TYR B 2 80  ? 14.597 24.063 -22.469 1.000 19.364 ? 80  TYR FFF CE1 1 ? 
ATOM   2169 C CE2 . TYR B 2 80  ? 16.671 25.228 -22.210 1.000 20.661 ? 80  TYR FFF CE2 1 ? 
ATOM   2170 C CZ  . TYR B 2 80  ? 15.556 24.637 -21.652 1.000 19.794 ? 80  TYR FFF CZ  1 ? 
ATOM   2171 O OH  . TYR B 2 80  ? 15.426 24.624 -20.292 1.000 24.272 ? 80  TYR FFF OH  1 ? 
ATOM   2172 N N   . LEU B 2 81  ? 15.786 23.281 -28.753 1.000 13.619 ? 81  LEU FFF N   1 ? 
ATOM   2173 C CA  . LEU B 2 81  ? 15.686 23.676 -30.177 1.000 15.200 ? 81  LEU FFF CA  1 ? 
ATOM   2174 C C   . LEU B 2 81  ? 14.361 24.405 -30.361 1.000 15.091 ? 81  LEU FFF C   1 ? 
ATOM   2175 O O   . LEU B 2 81  ? 13.300 23.758 -30.247 1.000 15.894 ? 81  LEU FFF O   1 ? 
ATOM   2176 C CB  . LEU B 2 81  ? 15.775 22.454 -31.093 1.000 15.300 ? 81  LEU FFF CB  1 ? 
ATOM   2177 C CG  . LEU B 2 81  ? 15.922 22.787 -32.580 1.000 15.049 ? 81  LEU FFF CG  1 ? 
ATOM   2178 C CD1 . LEU B 2 81  ? 17.281 23.414 -32.874 1.000 16.598 ? 81  LEU FFF CD1 1 ? 
ATOM   2179 C CD2 . LEU B 2 81  ? 15.712 21.550 -33.437 1.000 15.797 ? 81  LEU FFF CD2 1 ? 
ATOM   2180 N N   . GLN B 2 82  ? 14.440 25.707 -30.607 1.000 14.970 ? 82  GLN FFF N   1 ? 
ATOM   2181 C CA  . GLN B 2 82  ? 13.277 26.547 -30.978 1.000 15.998 ? 82  GLN FFF CA  1 ? 
ATOM   2182 C C   . GLN B 2 82  ? 13.113 26.455 -32.489 1.000 15.583 ? 82  GLN FFF C   1 ? 
ATOM   2183 O O   . GLN B 2 82  ? 14.058 26.799 -33.219 1.000 16.933 ? 82  GLN FFF O   1 ? 
ATOM   2184 C CB  . GLN B 2 82  ? 13.490 27.983 -30.521 1.000 17.199 ? 82  GLN FFF CB  1 ? 
ATOM   2185 C CG  . GLN B 2 82  ? 12.313 28.889 -30.850 1.000 18.460 ? 82  GLN FFF CG  1 ? 
ATOM   2186 C CD  . GLN B 2 82  ? 11.084 28.505 -30.068 1.000 17.369 ? 82  GLN FFF CD  1 ? 
ATOM   2187 O OE1 . GLN B 2 82  ? 11.151 28.108 -28.902 1.000 19.758 ? 82  GLN FFF OE1 1 ? 
ATOM   2188 N NE2 . GLN B 2 82  ? 9.935  28.614 -30.709 1.000 20.493 ? 82  GLN FFF NE2 1 ? 
ATOM   2189 N N   . MET B 2 83  ? 11.983 25.920 -32.935 1.000 16.017 ? 83  MET FFF N   1 ? 
ATOM   2190 C CA  . MET B 2 83  ? 11.735 25.628 -34.361 1.000 15.776 ? 83  MET FFF CA  1 ? 
ATOM   2191 C C   . MET B 2 83  ? 10.630 26.574 -34.834 1.000 16.245 ? 83  MET FFF C   1 ? 
ATOM   2192 O O   . MET B 2 83  ? 9.447  26.277 -34.625 1.000 17.330 ? 83  MET FFF O   1 ? 
ATOM   2193 C CB  . MET B 2 83  ? 11.325 24.164 -34.550 1.000 15.984 ? 83  MET FFF CB  1 ? 
ATOM   2194 C CG  . MET B 2 83  ? 12.352 23.172 -34.031 1.000 18.921 ? 83  MET FFF CG  1 ? 
ATOM   2195 S SD  . MET B 2 83  ? 11.714 21.472 -33.962 1.000 20.477 ? 83  MET FFF SD  1 ? 
ATOM   2196 C CE  . MET B 2 83  ? 11.622 21.093 -35.708 1.000 20.896 ? 83  MET FFF CE  1 ? 
ATOM   2197 N N   . ASN B 2 84  ? 11.022 27.686 -35.436 1.000 15.380 ? 84  ASN FFF N   1 ? 
ATOM   2198 C CA  . ASN B 2 84  ? 10.054 28.683 -35.956 1.000 16.247 ? 84  ASN FFF CA  1 ? 
ATOM   2199 C C   . ASN B 2 84  ? 9.926  28.508 -37.467 1.000 16.939 ? 84  ASN FFF C   1 ? 
ATOM   2200 O O   . ASN B 2 84  ? 10.767 27.805 -38.085 1.000 16.875 ? 84  ASN FFF O   1 ? 
ATOM   2201 C CB  . ASN B 2 84  ? 10.461 30.105 -35.588 1.000 16.941 ? 84  ASN FFF CB  1 ? 
ATOM   2202 C CG  . ASN B 2 84  ? 10.491 30.335 -34.093 1.000 16.543 ? 84  ASN FFF CG  1 ? 
ATOM   2203 O OD1 . ASN B 2 84  ? 9.738  29.718 -33.351 1.000 19.291 ? 84  ASN FFF OD1 1 ? 
ATOM   2204 N ND2 . ASN B 2 84  ? 11.364 31.222 -33.649 1.000 22.922 ? 84  ASN FFF ND2 1 ? 
ATOM   2205 N N   . SER B 2 85  ? 8.894  29.114 -38.048 1.000 17.613 ? 85  SER FFF N   1 ? 
ATOM   2206 C CA  . SER B 2 85  ? 8.720  29.184 -39.520 1.000 18.290 ? 85  SER FFF CA  1 ? 
ATOM   2207 C C   . SER B 2 85  ? 8.775  27.766 -40.099 1.000 17.197 ? 85  SER FFF C   1 ? 
ATOM   2208 O O   . SER B 2 85  ? 9.504  27.534 -41.074 1.000 16.812 ? 85  SER FFF O   1 ? 
ATOM   2209 C CB  . SER B 2 85  ? 9.764  30.060 -40.143 1.000 20.434 ? 85  SER FFF CB  1 ? 
ATOM   2210 O OG  . SER B 2 85  ? 9.673  31.383 -39.641 1.000 25.033 ? 85  SER FFF OG  1 ? 
ATOM   2211 N N   . LEU B 2 86  ? 8.049  26.843 -39.477 1.000 16.060 ? 86  LEU FFF N   1 ? 
ATOM   2212 C CA  . LEU B 2 86  ? 8.107  25.406 -39.836 1.000 15.317 ? 86  LEU FFF CA  1 ? 
ATOM   2213 C C   . LEU B 2 86  ? 7.717  25.198 -41.301 1.000 16.277 ? 86  LEU FFF C   1 ? 
ATOM   2214 O O   . LEU B 2 86  ? 6.752  25.833 -41.782 1.000 17.286 ? 86  LEU FFF O   1 ? 
ATOM   2215 C CB  . LEU B 2 86  ? 7.218  24.604 -38.893 1.000 16.778 ? 86  LEU FFF CB  1 ? 
ATOM   2216 C CG  . LEU B 2 86  ? 7.847  24.340 -37.528 1.000 17.715 ? 86  LEU FFF CG  1 ? 
ATOM   2217 C CD1 . LEU B 2 86  ? 6.817  23.818 -36.545 1.000 19.406 ? 86  LEU FFF CD1 1 ? 
ATOM   2218 C CD2 . LEU B 2 86  ? 9.011  23.368 -37.652 1.000 18.005 ? 86  LEU FFF CD2 1 ? 
ATOM   2219 N N   . LYS B 2 87  ? 8.470  24.319 -41.960 1.000 14.795 ? 87  LYS FFF N   1 ? 
ATOM   2220 C CA  . LYS B 2 87  ? 8.256  23.912 -43.370 1.000 15.226 ? 87  LYS FFF CA  1 ? 
ATOM   2221 C C   . LYS B 2 87  ? 7.818  22.450 -43.409 1.000 15.769 ? 87  LYS FFF C   1 ? 
ATOM   2222 O O   . LYS B 2 87  ? 8.195  21.701 -42.515 1.000 14.661 ? 87  LYS FFF O   1 ? 
ATOM   2223 C CB  . LYS B 2 87  ? 9.559  24.083 -44.143 1.000 16.931 ? 87  LYS FFF CB  1 ? 
ATOM   2224 C CG  . LYS B 2 87  ? 9.979  25.530 -44.359 1.000 18.611 ? 87  LYS FFF CG  1 ? 
ATOM   2225 C CD  . LYS B 2 87  ? 11.302 25.657 -45.072 1.000 23.259 ? 87  LYS FFF CD  1 ? 
ATOM   2226 C CE  . LYS B 2 87  ? 11.742 27.096 -45.224 1.000 27.326 ? 87  LYS FFF CE  1 ? 
ATOM   2227 N NZ  . LYS B 2 87  ? 12.858 27.230 -46.190 1.000 36.231 ? 87  LYS FFF NZ  1 ? 
ATOM   2228 N N   . TYR B 2 88  ? 7.063  22.054 -44.433 1.000 15.984 ? 88  TYR FFF N   1 ? 
ATOM   2229 C CA  . TYR B 2 88  ? 6.614  20.650 -44.592 1.000 15.993 ? 88  TYR FFF CA  1 ? 
ATOM   2230 C C   . TYR B 2 88  ? 7.829  19.722 -44.524 1.000 16.180 ? 88  TYR FFF C   1 ? 
ATOM   2231 O O   . TYR B 2 88  ? 7.741  18.657 -43.905 1.000 17.178 ? 88  TYR FFF O   1 ? 
ATOM   2232 C CB  . TYR B 2 88  ? 5.828  20.482 -45.894 1.000 16.191 ? 88  TYR FFF CB  1 ? 
ATOM   2233 C CG  . TYR B 2 88  ? 4.637  21.397 -45.957 1.000 16.825 ? 88  TYR FFF CG  1 ? 
ATOM   2234 C CD1 . TYR B 2 88  ? 3.568  21.218 -45.096 1.000 17.656 ? 88  TYR FFF CD1 1 ? 
ATOM   2235 C CD2 . TYR B 2 88  ? 4.609  22.489 -46.807 1.000 17.700 ? 88  TYR FFF CD2 1 ? 
ATOM   2236 C CE1 . TYR B 2 88  ? 2.476  22.068 -45.113 1.000 19.997 ? 88  TYR FFF CE1 1 ? 
ATOM   2237 C CE2 . TYR B 2 88  ? 3.532  23.359 -46.823 1.000 19.455 ? 88  TYR FFF CE2 1 ? 
ATOM   2238 C CZ  . TYR B 2 88  ? 2.463  23.147 -45.974 1.000 20.415 ? 88  TYR FFF CZ  1 ? 
ATOM   2239 O OH  . TYR B 2 88  ? 1.400  24.002 -45.992 1.000 25.404 ? 88  TYR FFF OH  1 ? 
ATOM   2240 N N   . GLU B 2 89  ? 8.939  20.120 -45.143 1.000 16.880 ? 89  GLU FFF N   1 ? 
ATOM   2241 C CA  . GLU B 2 89  ? 10.137 19.247 -45.248 1.000 19.725 ? 89  GLU FFF CA  1 ? 
ATOM   2242 C C   . GLU B 2 89  ? 10.908 19.222 -43.927 1.000 18.593 ? 89  GLU FFF C   1 ? 
ATOM   2243 O O   . GLU B 2 89  ? 11.871 18.458 -43.863 1.000 19.108 ? 89  GLU FFF O   1 ? 
ATOM   2244 C CB  . GLU B 2 89  ? 10.998 19.638 -46.449 1.000 26.877 ? 89  GLU FFF CB  1 ? 
ATOM   2245 C CG  . GLU B 2 89  ? 10.462 19.015 -47.727 1.000 36.923 ? 89  GLU FFF CG  1 ? 
ATOM   2246 C CD  . GLU B 2 89  ? 11.458 18.369 -48.675 1.000 34.346 ? 89  GLU FFF CD  1 ? 
ATOM   2247 O OE1 . GLU B 2 89  ? 11.412 17.124 -48.841 1.000 33.567 ? 89  GLU FFF OE1 1 ? 
ATOM   2248 O OE2 . GLU B 2 89  ? 12.239 19.112 -49.278 1.000 48.167 ? 89  GLU FFF OE2 1 ? 
ATOM   2249 N N   . ASP B 2 90  ? 10.474 19.955 -42.896 1.000 15.623 ? 90  ASP FFF N   1 ? 
ATOM   2250 C CA  . ASP B 2 90  ? 11.044 19.827 -41.530 1.000 15.712 ? 90  ASP FFF CA  1 ? 
ATOM   2251 C C   . ASP B 2 90  ? 10.489 18.574 -40.845 1.000 15.645 ? 90  ASP FFF C   1 ? 
ATOM   2252 O O   . ASP B 2 90  ? 11.004 18.209 -39.762 1.000 16.618 ? 90  ASP FFF O   1 ? 
ATOM   2253 C CB  . ASP B 2 90  ? 10.771 21.054 -40.663 1.000 14.960 ? 90  ASP FFF CB  1 ? 
ATOM   2254 C CG  . ASP B 2 90  ? 11.489 22.316 -41.093 1.000 16.161 ? 90  ASP FFF CG  1 ? 
ATOM   2255 O OD1 . ASP B 2 90  ? 12.641 22.225 -41.632 1.000 16.273 ? 90  ASP FFF OD1 1 ? 
ATOM   2256 O OD2 . ASP B 2 90  ? 10.902 23.394 -40.861 1.000 15.343 ? 90  ASP FFF OD2 1 ? 
ATOM   2257 N N   . THR B 2 91  ? 9.444  17.946 -41.388 1.000 14.771 ? 91  THR FFF N   1 ? 
ATOM   2258 C CA  . THR B 2 91  ? 8.884  16.693 -40.822 1.000 15.925 ? 91  THR FFF CA  1 ? 
ATOM   2259 C C   . THR B 2 91  ? 9.996  15.642 -40.725 1.000 15.921 ? 91  THR FFF C   1 ? 
ATOM   2260 O O   . THR B 2 91  ? 10.628 15.337 -41.752 1.000 19.517 ? 91  THR FFF O   1 ? 
ATOM   2261 C CB  . THR B 2 91  ? 7.697  16.191 -41.650 1.000 15.551 ? 91  THR FFF CB  1 ? 
ATOM   2262 O OG1 . THR B 2 91  ? 6.695  17.210 -41.567 1.000 16.316 ? 91  THR FFF OG1 1 ? 
ATOM   2263 C CG2 . THR B 2 91  ? 7.168  14.862 -41.165 1.000 16.377 ? 91  THR FFF CG2 1 ? 
ATOM   2264 N N   . ALA B 2 92  ? 10.214 15.082 -39.541 1.000 15.578 ? 92  ALA FFF N   1 ? 
ATOM   2265 C CA  . ALA B 2 92  ? 11.321 14.138 -39.282 1.000 16.262 ? 92  ALA FFF CA  1 ? 
ATOM   2266 C C   . ALA B 2 92  ? 11.277 13.700 -37.826 1.000 14.052 ? 92  ALA FFF C   1 ? 
ATOM   2267 O O   . ALA B 2 92  ? 10.566 14.318 -37.018 1.000 14.534 ? 92  ALA FFF O   1 ? 
ATOM   2268 C CB  . ALA B 2 92  ? 12.647 14.786 -39.589 1.000 14.816 ? 92  ALA FFF CB  1 ? 
ATOM   2269 N N   . VAL B 2 93  ? 12.051 12.679 -37.495 1.000 14.909 ? 93  VAL FFF N   1 ? 
ATOM   2270 C CA  . VAL B 2 93  ? 12.335 12.344 -36.078 1.000 15.116 ? 93  VAL FFF CA  1 ? 
ATOM   2271 C C   . VAL B 2 93  ? 13.565 13.152 -35.681 1.000 15.628 ? 93  VAL FFF C   1 ? 
ATOM   2272 O O   . VAL B 2 93  ? 14.603 13.018 -36.346 1.000 16.216 ? 93  VAL FFF O   1 ? 
ATOM   2273 C CB  . VAL B 2 93  ? 12.538 10.839 -35.877 1.000 16.601 ? 93  VAL FFF CB  1 ? 
ATOM   2274 C CG1 . VAL B 2 93  ? 12.911 10.538 -34.440 1.000 17.370 ? 93  VAL FFF CG1 1 ? 
ATOM   2275 C CG2 . VAL B 2 93  ? 11.297 10.065 -36.297 1.000 17.888 ? 93  VAL FFF CG2 1 ? 
ATOM   2276 N N   . TYR B 2 94  ? 13.412 13.996 -34.665 1.000 15.019 ? 94  TYR FFF N   1 ? 
ATOM   2277 C CA  . TYR B 2 94  ? 14.491 14.850 -34.120 1.000 14.591 ? 94  TYR FFF CA  1 ? 
ATOM   2278 C C   . TYR B 2 94  ? 15.148 14.136 -32.948 1.000 15.294 ? 94  TYR FFF C   1 ? 
ATOM   2279 O O   . TYR B 2 94  ? 14.443 13.591 -32.079 1.000 17.418 ? 94  TYR FFF O   1 ? 
ATOM   2280 C CB  . TYR B 2 94  ? 13.935 16.225 -33.746 1.000 13.889 ? 94  TYR FFF CB  1 ? 
ATOM   2281 C CG  . TYR B 2 94  ? 13.669 17.072 -34.956 1.000 13.782 ? 94  TYR FFF CG  1 ? 
ATOM   2282 C CD1 . TYR B 2 94  ? 12.633 16.756 -35.817 1.000 15.324 ? 94  TYR FFF CD1 1 ? 
ATOM   2283 C CD2 . TYR B 2 94  ? 14.478 18.151 -35.278 1.000 13.908 ? 94  TYR FFF CD2 1 ? 
ATOM   2284 C CE1 . TYR B 2 94  ? 12.396 17.503 -36.956 1.000 14.727 ? 94  TYR FFF CE1 1 ? 
ATOM   2285 C CE2 . TYR B 2 94  ? 14.254 18.905 -36.416 1.000 14.808 ? 94  TYR FFF CE2 1 ? 
ATOM   2286 C CZ  . TYR B 2 94  ? 13.205 18.582 -37.259 1.000 15.024 ? 94  TYR FFF CZ  1 ? 
ATOM   2287 O OH  . TYR B 2 94  ? 12.998 19.325 -38.390 1.000 14.450 ? 94  TYR FFF OH  1 ? 
ATOM   2288 N N   . TYR B 2 95  ? 16.475 14.202 -32.906 1.000 14.428 ? 95  TYR FFF N   1 ? 
ATOM   2289 C CA  . TYR B 2 95  ? 17.288 13.605 -31.826 1.000 15.331 ? 95  TYR FFF CA  1 ? 
ATOM   2290 C C   . TYR B 2 95  ? 18.191 14.658 -31.205 1.000 15.426 ? 95  TYR FFF C   1 ? 
ATOM   2291 O O   . TYR B 2 95  ? 18.900 15.360 -31.934 1.000 15.184 ? 95  TYR FFF O   1 ? 
ATOM   2292 C CB  . TYR B 2 95  ? 18.200 12.508 -32.374 1.000 16.055 ? 95  TYR FFF CB  1 ? 
ATOM   2293 C CG  . TYR B 2 95  ? 17.483 11.317 -32.942 1.000 16.739 ? 95  TYR FFF CG  1 ? 
ATOM   2294 C CD1 . TYR B 2 95  ? 17.056 11.299 -34.259 1.000 17.623 ? 95  TYR FFF CD1 1 ? 
ATOM   2295 C CD2 . TYR B 2 95  ? 17.216 10.214 -32.153 1.000 19.464 ? 95  TYR FFF CD2 1 ? 
ATOM   2296 C CE1 . TYR B 2 95  ? 16.396 10.202 -34.785 1.000 18.420 ? 95  TYR FFF CE1 1 ? 
ATOM   2297 C CE2 . TYR B 2 95  ? 16.563 9.108  -32.667 1.000 18.702 ? 95  TYR FFF CE2 1 ? 
ATOM   2298 C CZ  . TYR B 2 95  ? 16.134 9.109  -33.978 1.000 19.663 ? 95  TYR FFF CZ  1 ? 
ATOM   2299 O OH  . TYR B 2 95  ? 15.496 8.008  -34.477 1.000 23.402 ? 95  TYR FFF OH  1 ? 
ATOM   2300 N N   . CYS B 2 96  ? 18.197 14.742 -29.882 1.000 15.515 ? 96  CYS FFF N   1 ? 
ATOM   2301 C CA  A CYS B 2 96  ? 19.291 15.485 -29.205 0.500 15.321 ? 96  CYS FFF CA  1 ? 
ATOM   2302 C CA  B CYS B 2 96  ? 19.231 15.416 -29.069 0.500 15.716 ? 96  CYS FFF CA  1 ? 
ATOM   2303 C C   . CYS B 2 96  ? 20.489 14.542 -29.053 1.000 14.673 ? 96  CYS FFF C   1 ? 
ATOM   2304 O O   . CYS B 2 96  ? 20.326 13.296 -29.034 1.000 15.792 ? 96  CYS FFF O   1 ? 
ATOM   2305 C CB  A CYS B 2 96  ? 18.885 16.161 -27.901 0.500 17.054 ? 96  CYS FFF CB  1 ? 
ATOM   2306 C CB  B CYS B 2 96  ? 18.645 15.583 -27.677 0.500 17.949 ? 96  CYS FFF CB  1 ? 
ATOM   2307 S SG  A CYS B 2 96  ? 18.391 15.016 -26.592 0.500 19.105 ? 96  CYS FFF SG  1 ? 
ATOM   2308 S SG  B CYS B 2 96  ? 19.799 16.187 -26.429 0.500 21.369 ? 96  CYS FFF SG  1 ? 
ATOM   2309 N N   . ALA B 2 97  ? 21.670 15.136 -29.034 1.000 13.724 ? 97  ALA FFF N   1 ? 
ATOM   2310 C CA  . ALA B 2 97  ? 22.932 14.377 -29.015 1.000 14.253 ? 97  ALA FFF CA  1 ? 
ATOM   2311 C C   . ALA B 2 97  ? 23.973 15.124 -28.186 1.000 13.942 ? 97  ALA FFF C   1 ? 
ATOM   2312 O O   . ALA B 2 97  ? 23.930 16.369 -28.108 1.000 14.348 ? 97  ALA FFF O   1 ? 
ATOM   2313 C CB  . ALA B 2 97  ? 23.399 14.136 -30.427 1.000 16.158 ? 97  ALA FFF CB  1 ? 
ATOM   2314 N N   . GLY B 2 98  ? 24.866 14.371 -27.561 1.000 13.753 ? 98  GLY FFF N   1 ? 
ATOM   2315 C CA  . GLY B 2 98  ? 25.970 14.948 -26.787 1.000 13.754 ? 98  GLY FFF CA  1 ? 
ATOM   2316 C C   . GLY B 2 98  ? 27.295 14.434 -27.300 1.000 14.557 ? 98  GLY FFF C   1 ? 
ATOM   2317 O O   . GLY B 2 98  ? 27.383 13.239 -27.593 1.000 14.434 ? 98  GLY FFF O   1 ? 
ATOM   2318 N N   . SER B 2 99  ? 28.289 15.313 -27.396 1.000 14.515 ? 99  SER FFF N   1 ? 
ATOM   2319 C CA  . SER B 2 99  ? 29.660 14.953 -27.826 1.000 14.556 ? 99  SER FFF CA  1 ? 
ATOM   2320 C C   . SER B 2 99  ? 30.601 14.897 -26.617 1.000 15.035 ? 99  SER FFF C   1 ? 
ATOM   2321 O O   . SER B 2 99  ? 30.545 15.808 -25.777 1.000 17.801 ? 99  SER FFF O   1 ? 
ATOM   2322 C CB  . SER B 2 99  ? 30.160 15.927 -28.846 1.000 16.829 ? 99  SER FFF CB  1 ? 
ATOM   2323 O OG  . SER B 2 99  ? 31.493 15.607 -29.204 1.000 15.930 ? 99  SER FFF OG  1 ? 
ATOM   2324 N N   . LYS B 2 100 ? 31.484 13.897 -26.595 1.000 15.993 ? 100 LYS FFF N   1 ? 
ATOM   2325 C CA  . LYS B 2 100 ? 32.572 13.751 -25.595 1.000 18.212 ? 100 LYS FFF CA  1 ? 
ATOM   2326 C C   . LYS B 2 100 ? 33.779 14.608 -25.992 1.000 15.680 ? 100 LYS FFF C   1 ? 
ATOM   2327 O O   . LYS B 2 100 ? 34.710 14.739 -25.164 1.000 15.844 ? 100 LYS FFF O   1 ? 
ATOM   2328 C CB  . LYS B 2 100 ? 33.002 12.282 -25.506 1.000 20.411 ? 100 LYS FFF CB  1 ? 
ATOM   2329 C CG  . LYS B 2 100 ? 31.923 11.340 -25.000 1.000 28.689 ? 100 LYS FFF CG  1 ? 
ATOM   2330 C CD  . LYS B 2 100 ? 32.440 9.984  -24.561 1.000 36.465 ? 100 LYS FFF CD  1 ? 
ATOM   2331 C CE  . LYS B 2 100 ? 33.496 9.415  -25.483 1.000 38.987 ? 100 LYS FFF CE  1 ? 
ATOM   2332 N NZ  . LYS B 2 100 ? 33.809 8.005  -25.151 1.000 50.030 ? 100 LYS FFF NZ  1 ? 
ATOM   2333 N N   . ILE B 2 101 ? 33.775 15.140 -27.216 1.000 14.624 ? 101 ILE FFF N   1 ? 
ATOM   2334 C CA  . ILE B 2 101 ? 35.010 15.608 -27.907 1.000 14.383 ? 101 ILE FFF CA  1 ? 
ATOM   2335 C C   . ILE B 2 101 ? 35.053 17.128 -27.902 1.000 14.644 ? 101 ILE FFF C   1 ? 
ATOM   2336 O O   . ILE B 2 101 ? 34.081 17.744 -28.351 1.000 15.472 ? 101 ILE FFF O   1 ? 
ATOM   2337 C CB  . ILE B 2 101 ? 35.057 15.063 -29.340 1.000 14.042 ? 101 ILE FFF CB  1 ? 
ATOM   2338 C CG1 . ILE B 2 101 ? 34.743 13.562 -29.369 1.000 15.922 ? 101 ILE FFF CG1 1 ? 
ATOM   2339 C CG2 . ILE B 2 101 ? 36.401 15.393 -29.965 1.000 14.637 ? 101 ILE FFF CG2 1 ? 
ATOM   2340 C CD1 . ILE B 2 101 ? 34.736 12.943 -30.749 1.000 17.701 ? 101 ILE FFF CD1 1 ? 
ATOM   2341 N N   . THR B 2 102 ? 36.145 17.710 -27.422 1.000 13.243 ? 102 THR FFF N   1 ? 
ATOM   2342 C CA  . THR B 2 102 ? 36.374 19.173 -27.523 1.000 13.214 ? 102 THR FFF CA  1 ? 
ATOM   2343 C C   . THR B 2 102 ? 37.081 19.447 -28.854 1.000 13.307 ? 102 THR FFF C   1 ? 
ATOM   2344 O O   . THR B 2 102 ? 38.205 18.981 -29.030 1.000 13.929 ? 102 THR FFF O   1 ? 
ATOM   2345 C CB  . THR B 2 102 ? 37.164 19.705 -26.326 1.000 13.429 ? 102 THR FFF CB  1 ? 
ATOM   2346 O OG1 . THR B 2 102 ? 36.409 19.443 -25.144 1.000 14.639 ? 102 THR FFF OG1 1 ? 
ATOM   2347 C CG2 . THR B 2 102 ? 37.453 21.186 -26.426 1.000 13.693 ? 102 THR FFF CG2 1 ? 
ATOM   2348 N N   . ARG B 2 103 ? 36.404 20.128 -29.771 1.000 14.020 ? 103 ARG FFF N   1 ? 
ATOM   2349 C CA  . ARG B 2 103 ? 36.972 20.548 -31.071 1.000 13.516 ? 103 ARG FFF CA  1 ? 
ATOM   2350 C C   . ARG B 2 103 ? 37.083 22.069 -31.072 1.000 14.826 ? 103 ARG FFF C   1 ? 
ATOM   2351 O O   . ARG B 2 103 ? 36.136 22.743 -30.637 1.000 15.387 ? 103 ARG FFF O   1 ? 
ATOM   2352 C CB  . ARG B 2 103 ? 36.101 20.051 -32.229 1.000 13.360 ? 103 ARG FFF CB  1 ? 
ATOM   2353 C CG  . ARG B 2 103 ? 36.010 18.535 -32.357 1.000 14.089 ? 103 ARG FFF CG  1 ? 
ATOM   2354 C CD  . ARG B 2 103 ? 37.331 17.820 -32.549 1.000 13.892 ? 103 ARG FFF CD  1 ? 
ATOM   2355 N NE  . ARG B 2 103 ? 37.991 18.272 -33.760 1.000 14.353 ? 103 ARG FFF NE  1 ? 
ATOM   2356 C CZ  . ARG B 2 103 ? 39.254 18.024 -34.089 1.000 14.344 ? 103 ARG FFF CZ  1 ? 
ATOM   2357 N NH1 . ARG B 2 103 ? 40.034 17.296 -33.299 1.000 15.688 ? 103 ARG FFF NH1 1 ? 
ATOM   2358 N NH2 . ARG B 2 103 ? 39.726 18.512 -35.225 1.000 14.921 ? 103 ARG FFF NH2 1 ? 
ATOM   2359 N N   . SER B 2 104 ? 38.210 22.582 -31.545 1.000 13.804 ? 104 SER FFF N   1 ? 
ATOM   2360 C CA  A SER B 2 104 ? 38.491 24.038 -31.620 0.500 15.042 ? 104 SER FFF CA  1 ? 
ATOM   2361 C CA  B SER B 2 104 ? 38.473 24.045 -31.596 0.500 14.102 ? 104 SER FFF CA  1 ? 
ATOM   2362 C C   . SER B 2 104 ? 37.489 24.728 -32.554 1.000 15.465 ? 104 SER FFF C   1 ? 
ATOM   2363 O O   . SER B 2 104 ? 36.957 25.788 -32.182 1.000 16.010 ? 104 SER FFF O   1 ? 
ATOM   2364 C CB  A SER B 2 104 ? 39.900 24.269 -32.078 0.500 16.783 ? 104 SER FFF CB  1 ? 
ATOM   2365 C CB  B SER B 2 104 ? 39.904 24.334 -31.967 0.500 14.729 ? 104 SER FFF CB  1 ? 
ATOM   2366 O OG  A SER B 2 104 ? 40.100 25.634 -32.374 0.500 17.844 ? 104 SER FFF OG  1 ? 
ATOM   2367 O OG  B SER B 2 104 ? 40.774 23.961 -30.907 0.500 13.500 ? 104 SER FFF OG  1 ? 
ATOM   2368 N N   . LEU B 2 105 ? 37.273 24.160 -33.737 1.000 15.295 ? 105 LEU FFF N   1 ? 
ATOM   2369 C CA  . LEU B 2 105 ? 36.348 24.752 -34.735 1.000 15.401 ? 105 LEU FFF CA  1 ? 
ATOM   2370 C C   . LEU B 2 105 ? 34.946 24.214 -34.466 1.000 15.678 ? 105 LEU FFF C   1 ? 
ATOM   2371 O O   . LEU B 2 105 ? 34.735 22.998 -34.583 1.000 14.877 ? 105 LEU FFF O   1 ? 
ATOM   2372 C CB  . LEU B 2 105 ? 36.800 24.427 -36.160 1.000 16.195 ? 105 LEU FFF CB  1 ? 
ATOM   2373 C CG  . LEU B 2 105 ? 37.804 25.403 -36.756 1.000 18.095 ? 105 LEU FFF CG  1 ? 
ATOM   2374 C CD1 . LEU B 2 105 ? 39.096 25.425 -35.960 1.000 18.077 ? 105 LEU FFF CD1 1 ? 
ATOM   2375 C CD2 . LEU B 2 105 ? 38.070 25.066 -38.205 1.000 20.136 ? 105 LEU FFF CD2 1 ? 
ATOM   2376 N N   . LEU B 2 106 ? 34.007 25.097 -34.132 1.000 15.130 ? 106 LEU FFF N   1 ? 
ATOM   2377 C CA  . LEU B 2 106 ? 32.621 24.698 -33.803 1.000 14.235 ? 106 LEU FFF CA  1 ? 
ATOM   2378 C C   . LEU B 2 106 ? 32.005 23.962 -34.994 1.000 14.221 ? 106 LEU FFF C   1 ? 
ATOM   2379 O O   . LEU B 2 106 ? 31.192 23.065 -34.770 1.000 14.328 ? 106 LEU FFF O   1 ? 
ATOM   2380 C CB  . LEU B 2 106 ? 31.806 25.943 -33.444 1.000 16.246 ? 106 LEU FFF CB  1 ? 
ATOM   2381 C CG  . LEU B 2 106 ? 30.504 25.679 -32.690 1.000 15.936 ? 106 LEU FFF CG  1 ? 
ATOM   2382 C CD1 . LEU B 2 106 ? 30.778 25.108 -31.309 1.000 17.419 ? 106 LEU FFF CD1 1 ? 
ATOM   2383 C CD2 . LEU B 2 106 ? 29.690 26.956 -32.586 1.000 18.458 ? 106 LEU FFF CD2 1 ? 
ATOM   2384 N N   . SER B 2 107 ? 32.402 24.298 -36.224 1.000 15.832 ? 107 SER FFF N   1 ? 
ATOM   2385 C CA  . SER B 2 107 ? 31.863 23.657 -37.451 1.000 15.343 ? 107 SER FFF CA  1 ? 
ATOM   2386 C C   . SER B 2 107 ? 32.175 22.153 -37.449 1.000 15.022 ? 107 SER FFF C   1 ? 
ATOM   2387 O O   . SER B 2 107 ? 31.462 21.398 -38.131 1.000 15.756 ? 107 SER FFF O   1 ? 
ATOM   2388 C CB  . SER B 2 107 ? 32.381 24.339 -38.686 1.000 16.993 ? 107 SER FFF CB  1 ? 
ATOM   2389 O OG  . SER B 2 107 ? 33.797 24.324 -38.713 1.000 18.783 ? 107 SER FFF OG  1 ? 
ATOM   2390 N N   . ASP B 2 108 ? 33.193 21.703 -36.708 1.000 14.546 ? 108 ASP FFF N   1 ? 
ATOM   2391 C CA  . ASP B 2 108 ? 33.526 20.257 -36.635 1.000 15.075 ? 108 ASP FFF CA  1 ? 
ATOM   2392 C C   . ASP B 2 108 ? 32.345 19.467 -36.063 1.000 14.556 ? 108 ASP FFF C   1 ? 
ATOM   2393 O O   . ASP B 2 108 ? 32.251 18.260 -36.340 1.000 16.166 ? 108 ASP FFF O   1 ? 
ATOM   2394 C CB  . ASP B 2 108 ? 34.755 19.988 -35.762 1.000 14.036 ? 108 ASP FFF CB  1 ? 
ATOM   2395 C CG  . ASP B 2 108 ? 36.085 20.268 -36.432 1.000 18.019 ? 108 ASP FFF CG  1 ? 
ATOM   2396 O OD1 . ASP B 2 108 ? 36.082 20.652 -37.625 1.000 21.030 ? 108 ASP FFF OD1 1 ? 
ATOM   2397 O OD2 . ASP B 2 108 ? 37.119 20.074 -35.757 1.000 16.890 ? 108 ASP FFF OD2 1 ? 
ATOM   2398 N N   . TYR B 2 109 ? 31.473 20.093 -35.269 1.000 14.160 ? 109 TYR FFF N   1 ? 
ATOM   2399 C CA  . TYR B 2 109 ? 30.352 19.372 -34.620 1.000 14.560 ? 109 TYR FFF CA  1 ? 
ATOM   2400 C C   . TYR B 2 109 ? 29.287 19.007 -35.659 1.000 15.478 ? 109 TYR FFF C   1 ? 
ATOM   2401 O O   . TYR B 2 109 ? 28.380 18.272 -35.311 1.000 14.900 ? 109 TYR FFF O   1 ? 
ATOM   2402 C CB  . TYR B 2 109 ? 29.829 20.180 -33.436 1.000 13.481 ? 109 TYR FFF CB  1 ? 
ATOM   2403 C CG  . TYR B 2 109 ? 30.809 20.191 -32.290 1.000 13.628 ? 109 TYR FFF CG  1 ? 
ATOM   2404 C CD1 . TYR B 2 109 ? 31.088 19.032 -31.586 1.000 14.831 ? 109 TYR FFF CD1 1 ? 
ATOM   2405 C CD2 . TYR B 2 109 ? 31.486 21.342 -31.941 1.000 14.130 ? 109 TYR FFF CD2 1 ? 
ATOM   2406 C CE1 . TYR B 2 109 ? 31.997 19.024 -30.539 1.000 15.020 ? 109 TYR FFF CE1 1 ? 
ATOM   2407 C CE2 . TYR B 2 109 ? 32.400 21.354 -30.897 1.000 14.353 ? 109 TYR FFF CE2 1 ? 
ATOM   2408 C CZ  . TYR B 2 109 ? 32.663 20.189 -30.201 1.000 15.005 ? 109 TYR FFF CZ  1 ? 
ATOM   2409 O OH  . TYR B 2 109 ? 33.561 20.201 -29.166 1.000 14.337 ? 109 TYR FFF OH  1 ? 
ATOM   2410 N N   . ALA B 2 110 ? 29.400 19.491 -36.897 1.000 16.621 ? 110 ALA FFF N   1 ? 
ATOM   2411 C CA  . ALA B 2 110 ? 28.514 19.058 -37.996 1.000 16.100 ? 110 ALA FFF CA  1 ? 
ATOM   2412 C C   . ALA B 2 110 ? 28.923 17.663 -38.487 1.000 19.599 ? 110 ALA FFF C   1 ? 
ATOM   2413 O O   . ALA B 2 110 ? 28.070 16.996 -39.094 1.000 21.057 ? 110 ALA FFF O   1 ? 
ATOM   2414 C CB  . ALA B 2 110 ? 28.522 20.061 -39.112 1.000 16.010 ? 110 ALA FFF CB  1 ? 
ATOM   2415 N N   . THR B 2 111 ? 30.165 17.222 -38.256 1.000 16.696 ? 111 THR FFF N   1 ? 
ATOM   2416 C CA  . THR B 2 111 ? 30.697 15.985 -38.889 1.000 16.280 ? 111 THR FFF CA  1 ? 
ATOM   2417 C C   . THR B 2 111 ? 31.296 15.014 -37.873 1.000 17.017 ? 111 THR FFF C   1 ? 
ATOM   2418 O O   . THR B 2 111 ? 31.297 13.813 -38.168 1.000 17.431 ? 111 THR FFF O   1 ? 
ATOM   2419 C CB  . THR B 2 111 ? 31.694 16.313 -40.004 1.000 18.325 ? 111 THR FFF CB  1 ? 
ATOM   2420 O OG1 . THR B 2 111 ? 32.702 17.176 -39.489 1.000 18.453 ? 111 THR FFF OG1 1 ? 
ATOM   2421 C CG2 . THR B 2 111 ? 31.030 16.962 -41.198 1.000 19.856 ? 111 THR FFF CG2 1 ? 
ATOM   2422 N N   . TRP B 2 112 ? 31.819 15.491 -36.743 1.000 16.988 ? 112 TRP FFF N   1 ? 
ATOM   2423 C CA  . TRP B 2 112 ? 32.444 14.613 -35.728 1.000 16.574 ? 112 TRP FFF CA  1 ? 
ATOM   2424 C C   . TRP B 2 112 ? 31.373 13.797 -35.011 1.000 16.258 ? 112 TRP FFF C   1 ? 
ATOM   2425 O O   . TRP B 2 112 ? 30.198 14.183 -34.970 1.000 18.209 ? 112 TRP FFF O   1 ? 
ATOM   2426 C CB  . TRP B 2 112 ? 33.326 15.439 -34.787 1.000 15.980 ? 112 TRP FFF CB  1 ? 
ATOM   2427 C CG  . TRP B 2 112 ? 34.673 15.697 -35.384 1.000 17.407 ? 112 TRP FFF CG  1 ? 
ATOM   2428 C CD1 . TRP B 2 112 ? 34.964 16.447 -36.483 1.000 18.732 ? 112 TRP FFF CD1 1 ? 
ATOM   2429 C CD2 . TRP B 2 112 ? 35.913 15.129 -34.946 1.000 17.822 ? 112 TRP FFF CD2 1 ? 
ATOM   2430 N NE1 . TRP B 2 112 ? 36.309 16.416 -36.733 1.000 18.049 ? 112 TRP FFF NE1 1 ? 
ATOM   2431 C CE2 . TRP B 2 112 ? 36.918 15.618 -35.805 1.000 16.286 ? 112 TRP FFF CE2 1 ? 
ATOM   2432 C CE3 . TRP B 2 112 ? 36.258 14.278 -33.895 1.000 17.564 ? 112 TRP FFF CE3 1 ? 
ATOM   2433 C CZ2 . TRP B 2 112 ? 38.258 15.274 -35.640 1.000 16.952 ? 112 TRP FFF CZ2 1 ? 
ATOM   2434 C CZ3 . TRP B 2 112 ? 37.579 13.942 -33.733 1.000 18.433 ? 112 TRP FFF CZ3 1 ? 
ATOM   2435 C CH2 . TRP B 2 112 ? 38.557 14.438 -34.592 1.000 17.104 ? 112 TRP FFF CH2 1 ? 
ATOM   2436 N N   . PRO B 2 113 ? 31.750 12.629 -34.451 1.000 15.934 ? 113 PRO FFF N   1 ? 
ATOM   2437 C CA  . PRO B 2 113 ? 30.783 11.719 -33.845 1.000 16.279 ? 113 PRO FFF CA  1 ? 
ATOM   2438 C C   . PRO B 2 113 ? 30.263 12.163 -32.470 1.000 16.891 ? 113 PRO FFF C   1 ? 
ATOM   2439 O O   . PRO B 2 113 ? 30.989 12.787 -31.694 1.000 16.734 ? 113 PRO FFF O   1 ? 
ATOM   2440 C CB  . PRO B 2 113 ? 31.571 10.413 -33.734 1.000 16.322 ? 113 PRO FFF CB  1 ? 
ATOM   2441 C CG  . PRO B 2 113 ? 33.002 10.859 -33.543 1.000 16.983 ? 113 PRO FFF CG  1 ? 
ATOM   2442 C CD  . PRO B 2 113 ? 33.126 12.101 -34.396 1.000 15.134 ? 113 PRO FFF CD  1 ? 
ATOM   2443 N N   . TYR B 2 114 ? 29.004 11.812 -32.201 1.000 16.559 ? 114 TYR FFF N   1 ? 
ATOM   2444 C CA  . TYR B 2 114 ? 28.325 12.016 -30.900 1.000 16.250 ? 114 TYR FFF CA  1 ? 
ATOM   2445 C C   . TYR B 2 114 ? 28.094 10.655 -30.255 1.000 17.229 ? 114 TYR FFF C   1 ? 
ATOM   2446 O O   . TYR B 2 114 ? 27.591 9.749  -30.932 1.000 19.447 ? 114 TYR FFF O   1 ? 
ATOM   2447 C CB  . TYR B 2 114 ? 26.999 12.739 -31.102 1.000 16.178 ? 114 TYR FFF CB  1 ? 
ATOM   2448 C CG  . TYR B 2 114 ? 27.122 14.174 -31.523 1.000 15.858 ? 114 TYR FFF CG  1 ? 
ATOM   2449 C CD1 . TYR B 2 114 ? 27.609 14.504 -32.778 1.000 16.571 ? 114 TYR FFF CD1 1 ? 
ATOM   2450 C CD2 . TYR B 2 114 ? 26.719 15.202 -30.687 1.000 15.233 ? 114 TYR FFF CD2 1 ? 
ATOM   2451 C CE1 . TYR B 2 114 ? 27.695 15.821 -33.188 1.000 16.311 ? 114 TYR FFF CE1 1 ? 
ATOM   2452 C CE2 . TYR B 2 114 ? 26.788 16.526 -31.085 1.000 16.241 ? 114 TYR FFF CE2 1 ? 
ATOM   2453 C CZ  . TYR B 2 114 ? 27.285 16.833 -32.341 1.000 15.673 ? 114 TYR FFF CZ  1 ? 
ATOM   2454 O OH  . TYR B 2 114 ? 27.331 18.121 -32.769 1.000 18.161 ? 114 TYR FFF OH  1 ? 
ATOM   2455 N N   . ASP B 2 115 ? 28.446 10.543 -28.977 1.000 16.477 ? 115 ASP FFF N   1 ? 
ATOM   2456 C CA  . ASP B 2 115 ? 28.433 9.271  -28.213 1.000 18.467 ? 115 ASP FFF CA  1 ? 
ATOM   2457 C C   . ASP B 2 115 ? 27.116 9.125  -27.448 1.000 18.857 ? 115 ASP FFF C   1 ? 
ATOM   2458 O O   . ASP B 2 115 ? 26.820 8.004  -27.038 1.000 20.983 ? 115 ASP FFF O   1 ? 
ATOM   2459 C CB  . ASP B 2 115 ? 29.616 9.208  -27.248 1.000 22.898 ? 115 ASP FFF CB  1 ? 
ATOM   2460 C CG  . ASP B 2 115 ? 30.886 8.662  -27.877 1.000 33.065 ? 115 ASP FFF CG  1 ? 
ATOM   2461 O OD1 . ASP B 2 115 ? 31.614 9.446  -28.540 1.000 29.250 ? 115 ASP FFF OD1 1 ? 
ATOM   2462 O OD2 . ASP B 2 115 ? 31.138 7.451  -27.702 1.000 42.878 ? 115 ASP FFF OD2 1 ? 
ATOM   2463 N N   . TYR B 2 116 ? 26.360 10.205 -27.256 1.000 15.407 ? 116 TYR FFF N   1 ? 
ATOM   2464 C CA  . TYR B 2 116 ? 25.121 10.206 -26.440 1.000 15.031 ? 116 TYR FFF CA  1 ? 
ATOM   2465 C C   . TYR B 2 116 ? 23.953 10.697 -27.291 1.000 15.770 ? 116 TYR FFF C   1 ? 
ATOM   2466 O O   . TYR B 2 116 ? 24.101 11.699 -27.983 1.000 15.699 ? 116 TYR FFF O   1 ? 
ATOM   2467 C CB  . TYR B 2 116 ? 25.279 11.081 -25.201 1.000 17.169 ? 116 TYR FFF CB  1 ? 
ATOM   2468 C CG  . TYR B 2 116 ? 26.488 10.752 -24.368 1.000 20.011 ? 116 TYR FFF CG  1 ? 
ATOM   2469 C CD1 . TYR B 2 116 ? 26.495 9.667  -23.509 1.000 22.132 ? 116 TYR FFF CD1 1 ? 
ATOM   2470 C CD2 . TYR B 2 116 ? 27.627 11.528 -24.458 1.000 20.201 ? 116 TYR FFF CD2 1 ? 
ATOM   2471 C CE1 . TYR B 2 116 ? 27.607 9.375  -22.736 1.000 21.351 ? 116 TYR FFF CE1 1 ? 
ATOM   2472 C CE2 . TYR B 2 116 ? 28.745 11.247 -23.698 1.000 22.549 ? 116 TYR FFF CE2 1 ? 
ATOM   2473 C CZ  . TYR B 2 116 ? 28.735 10.168 -22.834 1.000 22.703 ? 116 TYR FFF CZ  1 ? 
ATOM   2474 O OH  . TYR B 2 116 ? 29.841 9.889  -22.086 1.000 24.460 ? 116 TYR FFF OH  1 ? 
ATOM   2475 N N   . TRP B 2 117 ? 22.821 10.003 -27.198 1.000 16.191 ? 117 TRP FFF N   1 ? 
ATOM   2476 C CA  . TRP B 2 117 ? 21.626 10.240 -28.038 1.000 15.291 ? 117 TRP FFF CA  1 ? 
ATOM   2477 C C   . TRP B 2 117 ? 20.360 10.191 -27.189 1.000 15.864 ? 117 TRP FFF C   1 ? 
ATOM   2478 O O   . TRP B 2 117 ? 20.223 9.277  -26.338 1.000 16.421 ? 117 TRP FFF O   1 ? 
ATOM   2479 C CB  . TRP B 2 117 ? 21.568 9.213  -29.167 1.000 15.430 ? 117 TRP FFF CB  1 ? 
ATOM   2480 C CG  . TRP B 2 117 ? 22.683 9.386  -30.143 1.000 16.109 ? 117 TRP FFF CG  1 ? 
ATOM   2481 C CD1 . TRP B 2 117 ? 23.920 8.815  -30.107 1.000 18.883 ? 117 TRP FFF CD1 1 ? 
ATOM   2482 C CD2 . TRP B 2 117 ? 22.671 10.252 -31.285 1.000 15.917 ? 117 TRP FFF CD2 1 ? 
ATOM   2483 N NE1 . TRP B 2 117 ? 24.672 9.252  -31.164 1.000 19.446 ? 117 TRP FFF NE1 1 ? 
ATOM   2484 C CE2 . TRP B 2 117 ? 23.929 10.127 -31.909 1.000 17.243 ? 117 TRP FFF CE2 1 ? 
ATOM   2485 C CE3 . TRP B 2 117 ? 21.717 11.098 -31.854 1.000 16.058 ? 117 TRP FFF CE3 1 ? 
ATOM   2486 C CZ2 . TRP B 2 117 ? 24.254 10.833 -33.061 1.000 17.668 ? 117 TRP FFF CZ2 1 ? 
ATOM   2487 C CZ3 . TRP B 2 117 ? 22.039 11.795 -32.995 1.000 17.015 ? 117 TRP FFF CZ3 1 ? 
ATOM   2488 C CH2 . TRP B 2 117 ? 23.287 11.651 -33.595 1.000 17.719 ? 117 TRP FFF CH2 1 ? 
ATOM   2489 N N   . GLY B 2 118 ? 19.458 11.127 -27.458 1.000 15.650 ? 118 GLY FFF N   1 ? 
ATOM   2490 C CA  . GLY B 2 118 ? 18.065 11.061 -26.996 1.000 16.097 ? 118 GLY FFF CA  1 ? 
ATOM   2491 C C   . GLY B 2 118 ? 17.291 9.968  -27.713 1.000 17.158 ? 118 GLY FFF C   1 ? 
ATOM   2492 O O   . GLY B 2 118 ? 17.834 9.329  -28.640 1.000 17.072 ? 118 GLY FFF O   1 ? 
ATOM   2493 N N   . GLN B 2 119 ? 16.040 9.777  -27.301 1.000 19.242 ? 119 GLN FFF N   1 ? 
ATOM   2494 C CA  . GLN B 2 119 ? 15.157 8.673  -27.759 1.000 20.342 ? 119 GLN FFF CA  1 ? 
ATOM   2495 C C   . GLN B 2 119 ? 14.615 8.944  -29.169 1.000 19.665 ? 119 GLN FFF C   1 ? 
ATOM   2496 O O   . GLN B 2 119 ? 14.243 7.980  -29.856 1.000 21.696 ? 119 GLN FFF O   1 ? 
ATOM   2497 C CB  . GLN B 2 119 ? 14.033 8.464  -26.738 1.000 20.084 ? 119 GLN FFF CB  1 ? 
ATOM   2498 C CG  . GLN B 2 119 ? 12.944 9.536  -26.735 1.000 23.796 ? 119 GLN FFF CG  1 ? 
ATOM   2499 C CD  . GLN B 2 119 ? 13.130 10.658 -25.737 1.000 26.062 ? 119 GLN FFF CD  1 ? 
ATOM   2500 O OE1 . GLN B 2 119 ? 14.246 11.085 -25.430 1.000 25.219 ? 119 GLN FFF OE1 1 ? 
ATOM   2501 N NE2 . GLN B 2 119 ? 12.016 11.174 -25.236 1.000 26.307 ? 119 GLN FFF NE2 1 ? 
ATOM   2502 N N   . GLY B 2 120 ? 14.596 10.199 -29.600 1.000 17.875 ? 120 GLY FFF N   1 ? 
ATOM   2503 C CA  . GLY B 2 120 ? 13.965 10.611 -30.864 1.000 17.543 ? 120 GLY FFF CA  1 ? 
ATOM   2504 C C   . GLY B 2 120 ? 12.560 11.114 -30.612 1.000 20.709 ? 120 GLY FFF C   1 ? 
ATOM   2505 O O   . GLY B 2 120 ? 11.819 10.473 -29.827 1.000 21.500 ? 120 GLY FFF O   1 ? 
ATOM   2506 N N   . THR B 2 121 ? 12.210 12.227 -31.246 1.000 17.617 ? 121 THR FFF N   1 ? 
ATOM   2507 C CA  . THR B 2 121 ? 10.898 12.893 -31.101 1.000 19.540 ? 121 THR FFF CA  1 ? 
ATOM   2508 C C   . THR B 2 121 ? 10.352 13.200 -32.491 1.000 17.315 ? 121 THR FFF C   1 ? 
ATOM   2509 O O   . THR B 2 121 ? 11.003 13.950 -33.244 1.000 15.826 ? 121 THR FFF O   1 ? 
ATOM   2510 C CB  . THR B 2 121 ? 11.023 14.160 -30.253 1.000 22.430 ? 121 THR FFF CB  1 ? 
ATOM   2511 O OG1 . THR B 2 121 ? 11.494 13.760 -28.963 1.000 25.364 ? 121 THR FFF OG1 1 ? 
ATOM   2512 C CG2 . THR B 2 121 ? 9.715  14.906 -30.136 1.000 25.822 ? 121 THR FFF CG2 1 ? 
ATOM   2513 N N   . GLN B 2 122 ? 9.164  12.686 -32.797 1.000 18.121 ? 122 GLN FFF N   1 ? 
ATOM   2514 C CA  . GLN B 2 122 ? 8.498  12.975 -34.087 1.000 17.565 ? 122 GLN FFF CA  1 ? 
ATOM   2515 C C   . GLN B 2 122 ? 8.074  14.445 -34.119 1.000 16.945 ? 122 GLN FFF C   1 ? 
ATOM   2516 O O   . GLN B 2 122 ? 7.432  14.932 -33.160 1.000 18.293 ? 122 GLN FFF O   1 ? 
ATOM   2517 C CB  . GLN B 2 122 ? 7.284  12.079 -34.315 1.000 17.938 ? 122 GLN FFF CB  1 ? 
ATOM   2518 C CG  . GLN B 2 122 ? 6.642  12.312 -35.677 1.000 17.478 ? 122 GLN FFF CG  1 ? 
ATOM   2519 C CD  . GLN B 2 122 ? 7.512  11.830 -36.811 1.000 19.852 ? 122 GLN FFF CD  1 ? 
ATOM   2520 O OE1 . GLN B 2 122 ? 7.938  10.677 -36.833 1.000 25.851 ? 122 GLN FFF OE1 1 ? 
ATOM   2521 N NE2 . GLN B 2 122 ? 7.743  12.692 -37.786 1.000 20.151 ? 122 GLN FFF NE2 1 ? 
ATOM   2522 N N   . VAL B 2 123 ? 8.415  15.117 -35.212 1.000 15.897 ? 123 VAL FFF N   1 ? 
ATOM   2523 C CA  . VAL B 2 123 ? 7.867  16.450 -35.558 1.000 16.311 ? 123 VAL FFF CA  1 ? 
ATOM   2524 C C   . VAL B 2 123 ? 7.137  16.284 -36.880 1.000 15.591 ? 123 VAL FFF C   1 ? 
ATOM   2525 O O   . VAL B 2 123 ? 7.730  15.731 -37.819 1.000 16.737 ? 123 VAL FFF O   1 ? 
ATOM   2526 C CB  . VAL B 2 123 ? 8.956  17.529 -35.644 1.000 16.282 ? 123 VAL FFF CB  1 ? 
ATOM   2527 C CG1 . VAL B 2 123 ? 8.445  18.775 -36.347 1.000 18.739 ? 123 VAL FFF CG1 1 ? 
ATOM   2528 C CG2 . VAL B 2 123 ? 9.501  17.860 -34.263 1.000 17.527 ? 123 VAL FFF CG2 1 ? 
ATOM   2529 N N   . THR B 2 124 ? 5.888  16.733 -36.939 1.000 15.831 ? 124 THR FFF N   1 ? 
ATOM   2530 C CA  . THR B 2 124 ? 5.080  16.637 -38.178 1.000 15.153 ? 124 THR FFF CA  1 ? 
ATOM   2531 C C   . THR B 2 124 ? 4.521  18.016 -38.504 1.000 15.184 ? 124 THR FFF C   1 ? 
ATOM   2532 O O   . THR B 2 124 ? 3.805  18.589 -37.655 1.000 16.926 ? 124 THR FFF O   1 ? 
ATOM   2533 C CB  . THR B 2 124 ? 3.949  15.616 -38.048 1.000 16.895 ? 124 THR FFF CB  1 ? 
ATOM   2534 O OG1 . THR B 2 124 ? 4.537  14.365 -37.707 1.000 20.108 ? 124 THR FFF OG1 1 ? 
ATOM   2535 C CG2 . THR B 2 124 ? 3.157  15.472 -39.328 1.000 17.780 ? 124 THR FFF CG2 1 ? 
ATOM   2536 N N   . VAL B 2 125 ? 4.802  18.501 -39.709 1.000 13.869 ? 125 VAL FFF N   1 ? 
ATOM   2537 C CA  . VAL B 2 125 ? 4.352  19.842 -40.167 1.000 14.753 ? 125 VAL FFF CA  1 ? 
ATOM   2538 C C   . VAL B 2 125 ? 3.217  19.671 -41.174 1.000 16.402 ? 125 VAL FFF C   1 ? 
ATOM   2539 O O   . VAL B 2 125 ? 3.408  18.995 -42.214 1.000 18.507 ? 125 VAL FFF O   1 ? 
ATOM   2540 C CB  . VAL B 2 125 ? 5.507  20.676 -40.735 1.000 16.131 ? 125 VAL FFF CB  1 ? 
ATOM   2541 C CG1 . VAL B 2 125 ? 5.024  22.048 -41.164 1.000 17.015 ? 125 VAL FFF CG1 1 ? 
ATOM   2542 C CG2 . VAL B 2 125 ? 6.629  20.778 -39.718 1.000 15.369 ? 125 VAL FFF CG2 1 ? 
ATOM   2543 N N   . SER B 2 126 ? 2.072  20.263 -40.864 1.000 16.748 ? 126 SER FFF N   1 ? 
ATOM   2544 C CA  . SER B 2 126 ? 0.819  20.023 -41.615 1.000 17.945 ? 126 SER FFF CA  1 ? 
ATOM   2545 C C   . SER B 2 126 ? 0.350  21.302 -42.304 1.000 19.028 ? 126 SER FFF C   1 ? 
ATOM   2546 O O   . SER B 2 126 ? 0.676  22.430 -41.864 1.000 18.867 ? 126 SER FFF O   1 ? 
ATOM   2547 C CB  . SER B 2 126 ? -0.245 19.469 -40.722 1.000 20.670 ? 126 SER FFF CB  1 ? 
ATOM   2548 O OG  . SER B 2 126 ? -0.540 20.395 -39.697 1.000 25.974 ? 126 SER FFF OG  1 ? 
ATOM   2549 N N   . SER B 2 127 ? -0.442 21.121 -43.352 1.000 18.605 ? 127 SER FFF N   1 ? 
ATOM   2550 C CA  . SER B 2 127 ? -1.085 22.228 -44.093 1.000 20.552 ? 127 SER FFF CA  1 ? 
ATOM   2551 C C   . SER B 2 127 ? -2.371 22.672 -43.380 1.000 27.372 ? 127 SER FFF C   1 ? 
ATOM   2552 O O   . SER B 2 127 ? -3.058 21.804 -42.789 1.000 29.041 ? 127 SER FFF O   1 ? 
ATOM   2553 C CB  . SER B 2 127 ? -1.365 21.821 -45.510 1.000 22.472 ? 127 SER FFF CB  1 ? 
ATOM   2554 O OG  . SER B 2 127 ? -1.921 22.918 -46.218 1.000 25.224 ? 127 SER FFF OG  1 ? 
ATOM   2555 N N   . LYS B 2 128 ? -2.648 23.980 -43.442 1.000 31.340 ? 128 LYS FFF N   1 ? 
ATOM   2556 C CA  . LYS B 2 128 ? -3.959 24.632 -43.156 1.000 45.112 ? 128 LYS FFF CA  1 ? 
ATOM   2557 C C   . LYS B 2 128 ? -4.882 23.687 -42.378 1.000 52.628 ? 128 LYS FFF C   1 ? 
ATOM   2558 O O   . LYS B 2 128 ? -6.065 23.554 -42.717 1.000 58.085 ? 128 LYS FFF O   1 ? 
ATOM   2559 C CB  . LYS B 2 128 ? -4.629 25.043 -44.473 1.000 51.643 ? 128 LYS FFF CB  1 ? 
ATOM   2560 C CG  . LYS B 2 128 ? -3.979 26.211 -45.202 1.000 55.620 ? 128 LYS FFF CG  1 ? 
ATOM   2561 C CD  . LYS B 2 128 ? -4.963 27.046 -46.002 1.000 65.875 ? 128 LYS FFF CD  1 ? 
ATOM   2562 C CE  . LYS B 2 128 ? -4.554 28.500 -46.108 1.000 69.599 ? 128 LYS FFF CE  1 ? 
ATOM   2563 N NZ  . LYS B 2 128 ? -5.528 29.284 -46.902 1.000 71.883 ? 128 LYS FFF NZ  1 ? 
HETATM 2564 C C1  . NAG C 3 .   ? 55.348 3.593  -8.480  1.000 24.988 ? 601 NAG EEE C1  1 ? 
HETATM 2565 C C2  . NAG C 3 .   ? 56.683 3.720  -7.795  1.000 25.636 ? 601 NAG EEE C2  1 ? 
HETATM 2566 C C3  . NAG C 3 .   ? 57.564 2.540  -8.196  1.000 28.115 ? 601 NAG EEE C3  1 ? 
HETATM 2567 C C4  . NAG C 3 .   ? 56.874 1.208  -7.891  1.000 29.134 ? 601 NAG EEE C4  1 ? 
HETATM 2568 C C5  . NAG C 3 .   ? 55.492 1.188  -8.523  1.000 27.428 ? 601 NAG EEE C5  1 ? 
HETATM 2569 C C6  . NAG C 3 .   ? 54.704 -0.067 -8.150  1.000 27.635 ? 601 NAG EEE C6  1 ? 
HETATM 2570 C C7  . NAG C 3 .   ? 57.907 5.782  -7.371  1.000 24.352 ? 601 NAG EEE C7  1 ? 
HETATM 2571 C C8  . NAG C 3 .   ? 58.668 6.922  -7.991  1.000 24.405 ? 601 NAG EEE C8  1 ? 
HETATM 2572 N N2  . NAG C 3 .   ? 57.321 4.951  -8.229  1.000 24.777 ? 601 NAG EEE N2  1 ? 
HETATM 2573 O O3  . NAG C 3 .   ? 58.823 2.690  -7.533  1.000 30.195 ? 601 NAG EEE O3  1 ? 
HETATM 2574 O O4  . NAG C 3 .   ? 57.622 0.122  -8.446  1.000 31.294 ? 601 NAG EEE O4  1 ? 
HETATM 2575 O O5  . NAG C 3 .   ? 54.767 2.338  -8.084  1.000 26.779 ? 601 NAG EEE O5  1 ? 
HETATM 2576 O O6  . NAG C 3 .   ? 54.440 -0.057 -6.744  1.000 26.963 ? 601 NAG EEE O6  1 ? 
HETATM 2577 O O7  . NAG C 3 .   ? 57.858 5.621  -6.160  1.000 27.807 ? 601 NAG EEE O7  1 ? 
HETATM 2578 C C1  . GOL D 4 .   ? 54.135 28.619 -13.139 1.000 55.093 ? 602 GOL EEE C1  1 ? 
HETATM 2579 O O1  . GOL D 4 .   ? 55.536 28.355 -13.148 1.000 53.035 ? 602 GOL EEE O1  1 ? 
HETATM 2580 C C2  . GOL D 4 .   ? 53.510 28.222 -11.821 1.000 57.924 ? 602 GOL EEE C2  1 ? 
HETATM 2581 O O2  . GOL D 4 .   ? 52.254 28.884 -11.674 1.000 66.672 ? 602 GOL EEE O2  1 ? 
HETATM 2582 C C3  . GOL D 4 .   ? 53.328 26.724 -11.685 1.000 56.498 ? 602 GOL EEE C3  1 ? 
HETATM 2583 O O3  . GOL D 4 .   ? 52.346 26.386 -10.708 1.000 58.819 ? 602 GOL EEE O3  1 ? 
HETATM 2584 O O   . HOH E 5 .   ? 54.293 30.362 -32.351 1.000 40.694 ? 701 HOH EEE O   1 ? 
HETATM 2585 O O   . HOH E 5 .   ? 44.591 36.908 -31.846 1.000 32.492 ? 702 HOH EEE O   1 ? 
HETATM 2586 O O   . HOH E 5 .   ? 67.212 17.132 -25.909 1.000 36.708 ? 703 HOH EEE O   1 ? 
HETATM 2587 O O   . HOH E 5 .   ? 58.938 8.432  -24.404 1.000 31.497 ? 704 HOH EEE O   1 ? 
HETATM 2588 O O   . HOH E 5 .   ? 49.057 11.242 -6.032  1.000 38.340 ? 705 HOH EEE O   1 ? 
HETATM 2589 O O   . HOH E 5 .   ? 57.258 3.800  -25.724 1.000 35.046 ? 706 HOH EEE O   1 ? 
HETATM 2590 O O   . HOH E 5 .   ? 48.476 18.171 -30.171 1.000 26.829 ? 707 HOH EEE O   1 ? 
HETATM 2591 O O   . HOH E 5 .   ? 54.512 2.058  -20.065 1.000 25.188 ? 708 HOH EEE O   1 ? 
HETATM 2592 O O   . HOH E 5 .   ? 61.079 23.906 -35.711 1.000 47.127 ? 709 HOH EEE O   1 ? 
HETATM 2593 O O   . HOH E 5 .   ? 35.118 27.607 -33.092 1.000 18.342 ? 710 HOH EEE O   1 ? 
HETATM 2594 O O   . HOH E 5 .   ? 41.722 9.124  -32.198 1.000 27.969 ? 711 HOH EEE O   1 ? 
HETATM 2595 O O   . HOH E 5 .   ? 44.600 30.720 -26.368 1.000 16.771 ? 712 HOH EEE O   1 ? 
HETATM 2596 O O   . HOH E 5 .   ? 45.508 32.438 -24.382 1.000 19.599 ? 713 HOH EEE O   1 ? 
HETATM 2597 O O   . HOH E 5 .   ? 34.966 30.734 -24.375 1.000 35.516 ? 714 HOH EEE O   1 ? 
HETATM 2598 O O   . HOH E 5 .   ? 51.516 0.507  -26.459 1.000 32.083 ? 715 HOH EEE O   1 ? 
HETATM 2599 O O   . HOH E 5 .   ? 42.189 31.404 -23.983 1.000 21.505 ? 716 HOH EEE O   1 ? 
HETATM 2600 O O   . HOH E 5 .   ? 42.043 2.280  -20.131 1.000 39.112 ? 717 HOH EEE O   1 ? 
HETATM 2601 O O   . HOH E 5 .   ? 59.059 2.880  -11.957 1.000 34.006 ? 718 HOH EEE O   1 ? 
HETATM 2602 O O   . HOH E 5 .   ? 67.473 15.492 2.467   1.000 42.775 ? 719 HOH EEE O   1 ? 
HETATM 2603 O O   . HOH E 5 .   ? 32.409 35.608 -34.103 1.000 34.791 ? 720 HOH EEE O   1 ? 
HETATM 2604 O O   . HOH E 5 .   ? 48.201 26.488 -22.665 1.000 15.910 ? 721 HOH EEE O   1 ? 
HETATM 2605 O O   . HOH E 5 .   ? 64.001 16.805 -28.479 1.000 26.936 ? 722 HOH EEE O   1 ? 
HETATM 2606 O O   . HOH E 5 .   ? 49.717 26.113 -20.255 1.000 14.935 ? 723 HOH EEE O   1 ? 
HETATM 2607 O O   . HOH E 5 .   ? 58.983 31.695 -25.142 1.000 30.842 ? 724 HOH EEE O   1 ? 
HETATM 2608 O O   . HOH E 5 .   ? 63.647 26.511 -24.416 1.000 23.148 ? 725 HOH EEE O   1 ? 
HETATM 2609 O O   . HOH E 5 .   ? 73.137 14.161 -18.144 1.000 49.442 ? 726 HOH EEE O   1 ? 
HETATM 2610 O O   . HOH E 5 .   ? 48.712 14.079 -11.109 1.000 22.883 ? 727 HOH EEE O   1 ? 
HETATM 2611 O O   . HOH E 5 .   ? 50.735 7.440  -12.809 1.000 28.762 ? 728 HOH EEE O   1 ? 
HETATM 2612 O O   . HOH E 5 .   ? 53.904 4.745  -5.427  1.000 31.881 ? 729 HOH EEE O   1 ? 
HETATM 2613 O O   . HOH E 5 .   ? 65.536 -2.293 -13.945 1.000 30.201 ? 730 HOH EEE O   1 ? 
HETATM 2614 O O   . HOH E 5 .   ? 31.370 29.521 -27.302 1.000 19.249 ? 731 HOH EEE O   1 ? 
HETATM 2615 O O   . HOH E 5 .   ? 38.950 17.903 -19.978 1.000 31.405 ? 732 HOH EEE O   1 ? 
HETATM 2616 O O   . HOH E 5 .   ? 42.066 16.916 -18.212 1.000 38.785 ? 733 HOH EEE O   1 ? 
HETATM 2617 O O   . HOH E 5 .   ? 66.796 24.884 -30.153 1.000 27.386 ? 734 HOH EEE O   1 ? 
HETATM 2618 O O   . HOH E 5 .   ? 68.867 31.478 -23.900 1.000 42.332 ? 735 HOH EEE O   1 ? 
HETATM 2619 O O   . HOH E 5 .   ? 61.192 23.863 -24.879 1.000 29.550 ? 736 HOH EEE O   1 ? 
HETATM 2620 O O   . HOH E 5 .   ? 37.280 30.378 -39.911 1.000 35.692 ? 737 HOH EEE O   1 ? 
HETATM 2621 O O   . HOH E 5 .   ? 43.854 11.310 -15.457 1.000 26.654 ? 738 HOH EEE O   1 ? 
HETATM 2622 O O   . HOH E 5 .   ? 63.635 15.696 -23.126 1.000 20.909 ? 739 HOH EEE O   1 ? 
HETATM 2623 O O   . HOH E 5 .   ? 68.564 16.043 -4.124  1.000 39.482 ? 740 HOH EEE O   1 ? 
HETATM 2624 O O   . HOH E 5 .   ? 64.834 4.687  -15.866 1.000 27.418 ? 741 HOH EEE O   1 ? 
HETATM 2625 O O   . HOH E 5 .   ? 59.924 -2.137 -19.764 1.000 26.797 ? 742 HOH EEE O   1 ? 
HETATM 2626 O O   . HOH E 5 .   ? 46.351 32.658 -35.975 1.000 52.616 ? 743 HOH EEE O   1 ? 
HETATM 2627 O O   . HOH E 5 .   ? 57.587 13.109 -33.408 1.000 33.111 ? 744 HOH EEE O   1 ? 
HETATM 2628 O O   . HOH E 5 .   ? 59.836 21.088 -13.208 1.000 19.615 ? 745 HOH EEE O   1 ? 
HETATM 2629 O O   . HOH E 5 .   ? 45.149 20.504 -13.954 1.000 29.697 ? 746 HOH EEE O   1 ? 
HETATM 2630 O O   . HOH E 5 .   ? 53.206 34.382 -22.974 1.000 32.532 ? 747 HOH EEE O   1 ? 
HETATM 2631 O O   . HOH E 5 .   ? 47.860 11.197 -35.749 1.000 36.429 ? 748 HOH EEE O   1 ? 
HETATM 2632 O O   . HOH E 5 .   ? 56.196 16.616 -32.221 1.000 19.488 ? 749 HOH EEE O   1 ? 
HETATM 2633 O O   . HOH E 5 .   ? 34.995 13.348 -22.773 1.000 25.770 ? 750 HOH EEE O   1 ? 
HETATM 2634 O O   . HOH E 5 .   ? 42.714 8.547  -17.878 1.000 24.838 ? 751 HOH EEE O   1 ? 
HETATM 2635 O O   . HOH E 5 .   ? 69.068 25.890 -14.294 1.000 40.775 ? 752 HOH EEE O   1 ? 
HETATM 2636 O O   . HOH E 5 .   ? 43.074 15.513 -16.350 1.000 31.591 ? 753 HOH EEE O   1 ? 
HETATM 2637 O O   . HOH E 5 .   ? 51.507 13.682 -10.916 1.000 21.645 ? 754 HOH EEE O   1 ? 
HETATM 2638 O O   . HOH E 5 .   ? 63.575 16.690 -31.406 1.000 22.075 ? 755 HOH EEE O   1 ? 
HETATM 2639 O O   . HOH E 5 .   ? 43.650 16.086 -31.451 1.000 18.428 ? 756 HOH EEE O   1 ? 
HETATM 2640 O O   . HOH E 5 .   ? 71.557 23.146 -16.898 1.000 41.734 ? 757 HOH EEE O   1 ? 
HETATM 2641 O O   . HOH E 5 .   ? 59.682 6.695  -4.411  1.000 40.588 ? 758 HOH EEE O   1 ? 
HETATM 2642 O O   . HOH E 5 .   ? 67.453 20.229 -25.983 1.000 23.910 ? 759 HOH EEE O   1 ? 
HETATM 2643 O O   . HOH E 5 .   ? 42.132 12.679 -24.321 1.000 14.923 ? 760 HOH EEE O   1 ? 
HETATM 2644 O O   . HOH E 5 .   ? 57.599 5.135  -10.970 1.000 29.638 ? 761 HOH EEE O   1 ? 
HETATM 2645 O O   . HOH E 5 .   ? 38.488 2.545  -29.935 1.000 30.408 ? 762 HOH EEE O   1 ? 
HETATM 2646 O O   . HOH E 5 .   ? 53.063 17.335 -10.705 1.000 17.087 ? 763 HOH EEE O   1 ? 
HETATM 2647 O O   . HOH E 5 .   ? 34.751 28.607 -35.518 1.000 25.024 ? 764 HOH EEE O   1 ? 
HETATM 2648 O O   . HOH E 5 .   ? 46.692 16.729 -22.194 1.000 14.627 ? 765 HOH EEE O   1 ? 
HETATM 2649 O O   . HOH E 5 .   ? 66.562 21.922 -28.876 1.000 24.790 ? 766 HOH EEE O   1 ? 
HETATM 2650 O O   . HOH E 5 .   ? 38.746 37.139 -36.295 1.000 26.454 ? 767 HOH EEE O   1 ? 
HETATM 2651 O O   . HOH E 5 .   ? 58.799 27.241 -28.040 1.000 31.015 ? 768 HOH EEE O   1 ? 
HETATM 2652 O O   . HOH E 5 .   ? 50.467 26.960 -12.675 1.000 39.142 ? 769 HOH EEE O   1 ? 
HETATM 2653 O O   . HOH E 5 .   ? 42.432 32.354 -26.835 1.000 17.795 ? 770 HOH EEE O   1 ? 
HETATM 2654 O O   . HOH E 5 .   ? 57.093 28.626 -25.926 1.000 20.410 ? 771 HOH EEE O   1 ? 
HETATM 2655 O O   . HOH E 5 .   ? 58.899 22.388 -23.822 1.000 19.696 ? 772 HOH EEE O   1 ? 
HETATM 2656 O O   . HOH E 5 .   ? 40.362 0.971  -29.959 1.000 39.916 ? 773 HOH EEE O   1 ? 
HETATM 2657 O O   . HOH E 5 .   ? 69.733 14.647 -22.269 1.000 27.884 ? 774 HOH EEE O   1 ? 
HETATM 2658 O O   . HOH E 5 .   ? 39.693 15.660 -31.017 1.000 17.329 ? 775 HOH EEE O   1 ? 
HETATM 2659 O O   . HOH E 5 .   ? 58.319 21.425 -34.640 1.000 48.135 ? 776 HOH EEE O   1 ? 
HETATM 2660 O O   . HOH E 5 .   ? 55.492 -1.900 -4.905  1.000 23.328 ? 777 HOH EEE O   1 ? 
HETATM 2661 O O   . HOH E 5 .   ? 53.287 15.414 -0.245  1.000 46.165 ? 778 HOH EEE O   1 ? 
HETATM 2662 O O   . HOH E 5 .   ? 52.368 19.062 -31.369 1.000 33.357 ? 779 HOH EEE O   1 ? 
HETATM 2663 O O   . HOH E 5 .   ? 55.444 25.855 -19.197 1.000 19.351 ? 780 HOH EEE O   1 ? 
HETATM 2664 O O   . HOH E 5 .   ? 69.421 23.210 -20.665 1.000 31.708 ? 781 HOH EEE O   1 ? 
HETATM 2665 O O   . HOH E 5 .   ? 58.448 12.276 -29.306 1.000 18.788 ? 782 HOH EEE O   1 ? 
HETATM 2666 O O   . HOH E 5 .   ? 42.729 3.783  -33.307 1.000 34.962 ? 783 HOH EEE O   1 ? 
HETATM 2667 O O   . HOH E 5 .   ? 38.745 10.141 -18.371 1.000 38.463 ? 784 HOH EEE O   1 ? 
HETATM 2668 O O   . HOH E 5 .   ? 70.149 11.895 -19.157 1.000 36.644 ? 785 HOH EEE O   1 ? 
HETATM 2669 O O   . HOH E 5 .   ? 31.001 33.227 -38.629 1.000 38.498 ? 786 HOH EEE O   1 ? 
HETATM 2670 O O   . HOH E 5 .   ? 49.351 15.804 -13.266 1.000 19.284 ? 787 HOH EEE O   1 ? 
HETATM 2671 O O   . HOH E 5 .   ? 63.293 28.141 -27.222 1.000 34.304 ? 788 HOH EEE O   1 ? 
HETATM 2672 O O   . HOH E 5 .   ? 38.491 39.112 -30.371 1.000 30.991 ? 789 HOH EEE O   1 ? 
HETATM 2673 O O   . HOH E 5 .   ? 40.694 25.777 -17.776 1.000 36.008 ? 790 HOH EEE O   1 ? 
HETATM 2674 O O   . HOH E 5 .   ? 53.141 9.806  -35.287 1.000 27.498 ? 791 HOH EEE O   1 ? 
HETATM 2675 O O   . HOH E 5 .   ? 51.319 24.564 -12.646 1.000 34.884 ? 792 HOH EEE O   1 ? 
HETATM 2676 O O   . HOH E 5 .   ? 30.626 38.581 -32.354 1.000 42.669 ? 793 HOH EEE O   1 ? 
HETATM 2677 O O   . HOH E 5 .   ? 49.329 32.687 -19.429 1.000 40.635 ? 794 HOH EEE O   1 ? 
HETATM 2678 O O   . HOH E 5 .   ? 62.122 14.452 -24.987 1.000 26.259 ? 795 HOH EEE O   1 ? 
HETATM 2679 O O   . HOH E 5 .   ? 55.689 1.804  -17.792 1.000 32.097 ? 796 HOH EEE O   1 ? 
HETATM 2680 O O   . HOH E 5 .   ? 50.564 1.271  -21.721 1.000 29.541 ? 797 HOH EEE O   1 ? 
HETATM 2681 O O   . HOH E 5 .   ? 36.182 10.923 -23.391 1.000 21.414 ? 798 HOH EEE O   1 ? 
HETATM 2682 O O   . HOH E 5 .   ? 46.409 15.172 -31.449 1.000 29.569 ? 799 HOH EEE O   1 ? 
HETATM 2683 O O   . HOH E 5 .   ? 56.901 3.439  -22.077 1.000 30.879 ? 800 HOH EEE O   1 ? 
HETATM 2684 O O   . HOH E 5 .   ? 52.018 30.993 -15.415 1.000 27.202 ? 801 HOH EEE O   1 ? 
HETATM 2685 O O   . HOH E 5 .   ? 42.743 36.250 -29.608 1.000 23.151 ? 802 HOH EEE O   1 ? 
HETATM 2686 O O   . HOH E 5 .   ? 52.550 1.823  -33.234 1.000 31.545 ? 803 HOH EEE O   1 ? 
HETATM 2687 O O   . HOH E 5 .   ? 60.042 27.384 -12.183 1.000 34.580 ? 804 HOH EEE O   1 ? 
HETATM 2688 O O   . HOH E 5 .   ? 41.144 43.464 -34.014 1.000 51.995 ? 805 HOH EEE O   1 ? 
HETATM 2689 O O   . HOH E 5 .   ? 52.842 5.750  -34.466 1.000 25.824 ? 806 HOH EEE O   1 ? 
HETATM 2690 O O   . HOH E 5 .   ? 47.718 30.447 -32.739 1.000 20.407 ? 807 HOH EEE O   1 ? 
HETATM 2691 O O   . HOH E 5 .   ? 53.413 20.443 -33.044 1.000 33.610 ? 808 HOH EEE O   1 ? 
HETATM 2692 O O   . HOH E 5 .   ? 75.875 15.937 -12.572 1.000 45.382 ? 809 HOH EEE O   1 ? 
HETATM 2693 O O   . HOH E 5 .   ? 65.786 8.662  -22.814 1.000 28.151 ? 810 HOH EEE O   1 ? 
HETATM 2694 O O   . HOH E 5 .   ? 47.015 36.060 -32.626 1.000 40.045 ? 811 HOH EEE O   1 ? 
HETATM 2695 O O   . HOH E 5 .   ? 39.117 32.243 -19.710 1.000 29.191 ? 812 HOH EEE O   1 ? 
HETATM 2696 O O   . HOH E 5 .   ? 49.582 22.459 -9.981  1.000 33.075 ? 813 HOH EEE O   1 ? 
HETATM 2697 O O   . HOH E 5 .   ? 58.125 8.008  -3.075  1.000 39.261 ? 814 HOH EEE O   1 ? 
HETATM 2698 O O   . HOH E 5 .   ? 45.520 31.277 -17.285 1.000 25.133 ? 815 HOH EEE O   1 ? 
HETATM 2699 O O   . HOH E 5 .   ? 67.189 1.017  -7.290  1.000 43.013 ? 816 HOH EEE O   1 ? 
HETATM 2700 O O   . HOH E 5 .   ? 45.822 -1.107 -16.656 1.000 43.105 ? 817 HOH EEE O   1 ? 
HETATM 2701 O O   . HOH E 5 .   ? 53.319 21.890 -4.144  1.000 30.733 ? 818 HOH EEE O   1 ? 
HETATM 2702 O O   . HOH E 5 .   ? 46.671 9.821  -6.979  1.000 37.088 ? 819 HOH EEE O   1 ? 
HETATM 2703 O O   . HOH E 5 .   ? 46.049 34.080 -26.719 1.000 23.694 ? 820 HOH EEE O   1 ? 
HETATM 2704 O O   . HOH E 5 .   ? 43.352 1.099  -23.134 1.000 42.119 ? 821 HOH EEE O   1 ? 
HETATM 2705 O O   . HOH E 5 .   ? 43.842 19.008 -16.319 1.000 22.277 ? 822 HOH EEE O   1 ? 
HETATM 2706 O O   . HOH E 5 .   ? 45.295 11.348 -8.745  1.000 45.809 ? 823 HOH EEE O   1 ? 
HETATM 2707 O O   . HOH E 5 .   ? 56.795 27.293 -8.546  1.000 33.293 ? 824 HOH EEE O   1 ? 
HETATM 2708 O O   . HOH E 5 .   ? 37.843 38.162 -38.734 1.000 34.979 ? 825 HOH EEE O   1 ? 
HETATM 2709 O O   . HOH E 5 .   ? 52.596 26.412 -32.337 1.000 51.917 ? 826 HOH EEE O   1 ? 
HETATM 2710 O O   . HOH E 5 .   ? 75.154 18.808 -12.002 1.000 54.158 ? 827 HOH EEE O   1 ? 
HETATM 2711 O O   . HOH E 5 .   ? 58.155 28.610 -31.942 1.000 38.549 ? 828 HOH EEE O   1 ? 
HETATM 2712 O O   . HOH E 5 .   ? 48.524 6.556  -35.190 1.000 37.105 ? 829 HOH EEE O   1 ? 
HETATM 2713 O O   . HOH E 5 .   ? 50.446 -0.693 -29.033 1.000 42.030 ? 830 HOH EEE O   1 ? 
HETATM 2714 O O   . HOH E 5 .   ? 38.263 0.697  -22.695 1.000 30.848 ? 831 HOH EEE O   1 ? 
HETATM 2715 O O   . HOH E 5 .   ? 65.818 24.729 -14.550 1.000 38.925 ? 832 HOH EEE O   1 ? 
HETATM 2716 O O   . HOH E 5 .   ? 57.889 8.974  -27.097 1.000 36.883 ? 833 HOH EEE O   1 ? 
HETATM 2717 O O   . HOH E 5 .   ? 67.302 30.266 -20.295 1.000 42.451 ? 834 HOH EEE O   1 ? 
HETATM 2718 O O   . HOH E 5 .   ? 41.255 10.829 -18.517 1.000 24.096 ? 835 HOH EEE O   1 ? 
HETATM 2719 O O   . HOH E 5 .   ? 62.244 11.934 -26.009 1.000 37.548 ? 836 HOH EEE O   1 ? 
HETATM 2720 O O   . HOH E 5 .   ? 55.121 9.079  -2.432  1.000 40.240 ? 837 HOH EEE O   1 ? 
HETATM 2721 O O   . HOH E 5 .   ? 34.303 10.756 -20.138 1.000 31.277 ? 838 HOH EEE O   1 ? 
HETATM 2722 O O   . HOH E 5 .   ? 48.213 28.975 -14.110 1.000 38.504 ? 839 HOH EEE O   1 ? 
HETATM 2723 O O   . HOH E 5 .   ? 43.373 23.730 -13.530 1.000 50.319 ? 840 HOH EEE O   1 ? 
HETATM 2724 O O   . HOH E 5 .   ? 39.043 3.074  -34.378 1.000 55.567 ? 841 HOH EEE O   1 ? 
HETATM 2725 O O   . HOH E 5 .   ? 72.119 1.987  -8.649  1.000 37.054 ? 842 HOH EEE O   1 ? 
HETATM 2726 O O   . HOH E 5 .   ? 62.382 9.709  -2.870  1.000 33.012 ? 843 HOH EEE O   1 ? 
HETATM 2727 O O   . HOH E 5 .   ? 46.203 33.637 -19.501 1.000 56.808 ? 844 HOH EEE O   1 ? 
HETATM 2728 O O   . HOH E 5 .   ? 32.554 31.344 -25.714 1.000 32.071 ? 845 HOH EEE O   1 ? 
HETATM 2729 O O   . HOH E 5 .   ? 57.983 17.384 -0.201  1.000 35.662 ? 846 HOH EEE O   1 ? 
HETATM 2730 O O   . HOH E 5 .   ? 35.882 16.842 -21.923 1.000 43.926 ? 847 HOH EEE O   1 ? 
HETATM 2731 O O   . HOH E 5 .   ? 46.553 6.520  -34.707 1.000 29.859 ? 848 HOH EEE O   1 ? 
HETATM 2732 O O   . HOH E 5 .   ? 49.213 35.571 -25.201 1.000 46.704 ? 849 HOH EEE O   1 ? 
HETATM 2733 O O   . HOH E 5 .   ? 52.213 15.635 -8.874  1.000 31.944 ? 850 HOH EEE O   1 ? 
HETATM 2734 O O   . HOH E 5 .   ? 51.436 2.157  -9.360  1.000 41.749 ? 851 HOH EEE O   1 ? 
HETATM 2735 O O   . HOH E 5 .   ? 42.802 8.563  -14.936 1.000 41.918 ? 852 HOH EEE O   1 ? 
HETATM 2736 O O   . HOH E 5 .   ? 55.572 5.733  -12.879 1.000 32.026 ? 853 HOH EEE O   1 ? 
HETATM 2737 O O   . HOH E 5 .   ? 39.895 40.954 -43.927 1.000 56.736 ? 854 HOH EEE O   1 ? 
HETATM 2738 O O   . HOH E 5 .   ? 68.660 24.500 -26.162 1.000 35.496 ? 855 HOH EEE O   1 ? 
HETATM 2739 O O   . HOH E 5 .   ? 55.216 1.336  -26.225 1.000 50.327 ? 856 HOH EEE O   1 ? 
HETATM 2740 O O   . HOH E 5 .   ? 38.378 7.755  -19.511 1.000 40.500 ? 857 HOH EEE O   1 ? 
HETATM 2741 O O   . HOH E 5 .   ? 51.117 7.561  -35.068 1.000 33.162 ? 858 HOH EEE O   1 ? 
HETATM 2742 O O   . HOH E 5 .   ? 60.623 29.038 -29.302 1.000 45.969 ? 859 HOH EEE O   1 ? 
HETATM 2743 O O   . HOH E 5 .   ? 61.812 25.614 -11.703 1.000 49.478 ? 860 HOH EEE O   1 ? 
HETATM 2744 O O   . HOH E 5 .   ? 59.170 11.739 -31.890 1.000 34.844 ? 861 HOH EEE O   1 ? 
HETATM 2745 O O   . HOH E 5 .   ? 60.664 11.023 -27.901 1.000 36.355 ? 862 HOH EEE O   1 ? 
HETATM 2746 O O   . HOH E 5 .   ? 54.673 2.879  -14.930 1.000 43.887 ? 863 HOH EEE O   1 ? 
HETATM 2747 O O   . HOH E 5 .   ? 39.691 10.723 -32.911 1.000 24.947 ? 864 HOH EEE O   1 ? 
HETATM 2748 O O   . HOH E 5 .   ? 50.180 4.725  -13.040 1.000 45.238 ? 865 HOH EEE O   1 ? 
HETATM 2749 O O   . HOH E 5 .   ? 41.926 13.885 -17.883 1.000 43.842 ? 866 HOH EEE O   1 ? 
HETATM 2750 O O   . HOH E 5 .   ? 52.817 3.183  -35.336 1.000 52.239 ? 867 HOH EEE O   1 ? 
HETATM 2751 O O   . HOH E 5 .   ? 44.272 39.719 -31.738 1.000 48.039 ? 868 HOH EEE O   1 ? 
HETATM 2752 O O   . HOH E 5 .   ? 56.598 27.185 -4.004  1.000 53.972 ? 869 HOH EEE O   1 ? 
HETATM 2753 O O   . HOH E 5 .   ? 43.410 34.759 -27.374 1.000 22.908 ? 870 HOH EEE O   1 ? 
HETATM 2754 O O   . HOH E 5 .   ? 47.692 29.564 -35.512 1.000 41.639 ? 871 HOH EEE O   1 ? 
HETATM 2755 O O   . HOH E 5 .   ? 55.682 25.461 -6.552  1.000 35.272 ? 872 HOH EEE O   1 ? 
HETATM 2756 O O   . HOH F 5 .   ? 26.363 2.427  -16.428 1.000 20.581 ? 201 HOH FFF O   1 ? 
HETATM 2757 O O   . HOH F 5 .   ? 13.212 16.893 -42.356 1.000 29.298 ? 202 HOH FFF O   1 ? 
HETATM 2758 O O   . HOH F 5 .   ? 25.110 21.974 -16.409 1.000 32.638 ? 203 HOH FFF O   1 ? 
HETATM 2759 O O   . HOH F 5 .   ? 22.025 31.045 -32.007 1.000 24.039 ? 204 HOH FFF O   1 ? 
HETATM 2760 O O   . HOH F 5 .   ? 22.156 8.009  -40.752 1.000 44.509 ? 205 HOH FFF O   1 ? 
HETATM 2761 O O   . HOH F 5 .   ? 3.926  18.189 -28.010 1.000 31.466 ? 206 HOH FFF O   1 ? 
HETATM 2762 O O   . HOH F 5 .   ? 16.402 29.008 -24.265 1.000 29.253 ? 207 HOH FFF O   1 ? 
HETATM 2763 O O   . HOH F 5 .   ? 31.261 15.386 -31.906 1.000 22.627 ? 208 HOH FFF O   1 ? 
HETATM 2764 O O   . HOH F 5 .   ? 14.694 7.867  -36.982 1.000 28.087 ? 209 HOH FFF O   1 ? 
HETATM 2765 O O   . HOH F 5 .   ? 36.967 19.866 -20.760 1.000 31.083 ? 210 HOH FFF O   1 ? 
HETATM 2766 O O   . HOH F 5 .   ? 21.596 30.531 -28.905 1.000 24.673 ? 211 HOH FFF O   1 ? 
HETATM 2767 O O   . HOH F 5 .   ? 23.656 30.495 -26.891 1.000 22.596 ? 212 HOH FFF O   1 ? 
HETATM 2768 O O   . HOH F 5 .   ? 27.270 9.262  -14.930 1.000 37.158 ? 213 HOH FFF O   1 ? 
HETATM 2769 O O   . HOH F 5 .   ? 13.725 6.863  -32.872 1.000 43.367 ? 214 HOH FFF O   1 ? 
HETATM 2770 O O   . HOH F 5 .   ? 38.831 21.816 -34.710 1.000 16.720 ? 215 HOH FFF O   1 ? 
HETATM 2771 O O   . HOH F 5 .   ? 25.534 19.332 -20.019 1.000 22.173 ? 216 HOH FFF O   1 ? 
HETATM 2772 O O   . HOH F 5 .   ? 22.840 18.925 -42.226 1.000 24.729 ? 217 HOH FFF O   1 ? 
HETATM 2773 O O   . HOH F 5 .   ? 10.081 15.670 -44.344 1.000 26.686 ? 218 HOH FFF O   1 ? 
HETATM 2774 O O   . HOH F 5 .   ? 21.183 28.982 -45.262 1.000 53.304 ? 219 HOH FFF O   1 ? 
HETATM 2775 O O   . HOH F 5 .   ? 10.003 21.705 -25.047 1.000 29.168 ? 220 HOH FFF O   1 ? 
HETATM 2776 O O   . HOH F 5 .   ? 17.648 28.065 -14.971 1.000 42.062 ? 221 HOH FFF O   1 ? 
HETATM 2777 O O   . HOH F 5 .   ? 18.383 7.002  -29.838 1.000 34.755 ? 222 HOH FFF O   1 ? 
HETATM 2778 O O   . HOH F 5 .   ? 34.852 22.019 -39.568 1.000 23.691 ? 223 HOH FFF O   1 ? 
HETATM 2779 O O   . HOH F 5 .   ? 26.919 17.189 -41.508 1.000 26.927 ? 224 HOH FFF O   1 ? 
HETATM 2780 O O   . HOH F 5 .   ? 20.261 8.854  -23.688 1.000 22.746 ? 225 HOH FFF O   1 ? 
HETATM 2781 O O   . HOH F 5 .   ? 27.587 26.295 -46.285 1.000 49.324 ? 226 HOH FFF O   1 ? 
HETATM 2782 O O   . HOH F 5 .   ? 9.700  14.600 -27.145 1.000 34.001 ? 227 HOH FFF O   1 ? 
HETATM 2783 O O   . HOH F 5 .   ? 16.197 8.899  -23.611 1.000 36.080 ? 228 HOH FFF O   1 ? 
HETATM 2784 O O   . HOH F 5 .   ? 1.222  29.246 -39.549 1.000 34.740 ? 229 HOH FFF O   1 ? 
HETATM 2785 O O   . HOH F 5 .   ? 31.205 12.091 -28.816 1.000 16.544 ? 230 HOH FFF O   1 ? 
HETATM 2786 O O   . HOH F 5 .   ? 14.662 20.550 -18.364 1.000 26.440 ? 231 HOH FFF O   1 ? 
HETATM 2787 O O   . HOH F 5 .   ? 38.520 20.576 -38.768 1.000 23.037 ? 232 HOH FFF O   1 ? 
HETATM 2788 O O   . HOH F 5 .   ? 13.411 23.109 -19.326 1.000 26.776 ? 233 HOH FFF O   1 ? 
HETATM 2789 O O   . HOH F 5 .   ? 14.328 30.266 -33.744 1.000 25.788 ? 234 HOH FFF O   1 ? 
HETATM 2790 O O   . HOH F 5 .   ? 4.007  16.444 -42.882 1.000 29.799 ? 235 HOH FFF O   1 ? 
HETATM 2791 O O   . HOH F 5 .   ? 5.862  31.976 -40.021 1.000 43.433 ? 236 HOH FFF O   1 ? 
HETATM 2792 O O   . HOH F 5 .   ? 36.202 16.821 -24.275 1.000 21.176 ? 237 HOH FFF O   1 ? 
HETATM 2793 O O   . HOH F 5 .   ? 16.410 27.720 -28.326 1.000 19.953 ? 238 HOH FFF O   1 ? 
HETATM 2794 O O   . HOH F 5 .   ? 18.298 30.831 -36.913 1.000 35.843 ? 239 HOH FFF O   1 ? 
HETATM 2795 O O   . HOH F 5 .   ? 16.072 28.257 -43.117 1.000 27.005 ? 240 HOH FFF O   1 ? 
HETATM 2796 O O   . HOH F 5 .   ? 23.993 24.194 -48.285 1.000 34.558 ? 241 HOH FFF O   1 ? 
HETATM 2797 O O   . HOH F 5 .   ? 20.005 7.086  -31.985 1.000 38.162 ? 242 HOH FFF O   1 ? 
HETATM 2798 O O   . HOH F 5 .   ? 16.582 5.209  -48.710 1.000 29.108 ? 243 HOH FFF O   1 ? 
HETATM 2799 O O   . HOH F 5 .   ? 26.438 25.401 -42.057 1.000 26.964 ? 244 HOH FFF O   1 ? 
HETATM 2800 O O   . HOH F 5 .   ? 13.034 16.906 -21.576 1.000 25.896 ? 245 HOH FFF O   1 ? 
HETATM 2801 O O   . HOH F 5 .   ? 27.311 27.622 -41.092 1.000 31.773 ? 246 HOH FFF O   1 ? 
HETATM 2802 O O   . HOH F 5 .   ? 14.951 24.865 -45.508 1.000 32.957 ? 247 HOH FFF O   1 ? 
HETATM 2803 O O   . HOH F 5 .   ? 35.128 26.543 -39.637 1.000 41.650 ? 248 HOH FFF O   1 ? 
HETATM 2804 O O   . HOH F 5 .   ? 6.164  13.468 -31.207 1.000 26.635 ? 249 HOH FFF O   1 ? 
HETATM 2805 O O   . HOH F 5 .   ? 33.771 8.567  -30.015 1.000 38.809 ? 250 HOH FFF O   1 ? 
HETATM 2806 O O   . HOH F 5 .   ? 9.415  13.136 -22.635 1.000 39.867 ? 251 HOH FFF O   1 ? 
HETATM 2807 O O   . HOH F 5 .   ? 11.855 32.515 -38.382 1.000 32.597 ? 252 HOH FFF O   1 ? 
HETATM 2808 O O   . HOH F 5 .   ? 17.592 13.294 -18.175 1.000 27.661 ? 253 HOH FFF O   1 ? 
HETATM 2809 O O   . HOH F 5 .   ? 32.430 19.821 -40.258 1.000 24.214 ? 254 HOH FFF O   1 ? 
HETATM 2810 O O   . HOH F 5 .   ? 35.182 26.976 -21.867 1.000 27.531 ? 255 HOH FFF O   1 ? 
HETATM 2811 O O   . HOH F 5 .   ? 11.428 11.559 -46.937 1.000 19.242 ? 256 HOH FFF O   1 ? 
HETATM 2812 O O   . HOH F 5 .   ? 28.150 15.076 -36.645 1.000 31.175 ? 257 HOH FFF O   1 ? 
HETATM 2813 O O   . HOH F 5 .   ? 18.714 17.910 -16.527 1.000 29.872 ? 258 HOH FFF O   1 ? 
HETATM 2814 O O   . HOH F 5 .   ? 14.287 22.018 -43.889 1.000 30.796 ? 259 HOH FFF O   1 ? 
HETATM 2815 O O   . HOH F 5 .   ? -0.519 21.756 -32.884 1.000 26.360 ? 260 HOH FFF O   1 ? 
HETATM 2816 O O   . HOH F 5 .   ? 7.007  28.121 -43.386 1.000 41.880 ? 261 HOH FFF O   1 ? 
HETATM 2817 O O   . HOH F 5 .   ? 29.591 7.664  -20.373 1.000 40.760 ? 262 HOH FFF O   1 ? 
HETATM 2818 O O   . HOH F 5 .   ? 31.340 15.313 -22.966 1.000 28.124 ? 263 HOH FFF O   1 ? 
HETATM 2819 O O   . HOH F 5 .   ? 20.513 31.603 -38.464 1.000 33.410 ? 264 HOH FFF O   1 ? 
HETATM 2820 O O   . HOH F 5 .   ? 33.033 17.109 -22.019 1.000 40.663 ? 265 HOH FFF O   1 ? 
HETATM 2821 O O   . HOH F 5 .   ? 7.666  11.148 -30.953 1.000 30.349 ? 266 HOH FFF O   1 ? 
HETATM 2822 O O   . HOH F 5 .   ? 11.490 22.878 -21.252 1.000 38.280 ? 267 HOH FFF O   1 ? 
HETATM 2823 O O   . HOH F 5 .   ? 6.927  21.493 -28.699 1.000 23.152 ? 268 HOH FFF O   1 ? 
HETATM 2824 O O   . HOH F 5 .   ? 29.332 11.175 -17.473 1.000 35.236 ? 269 HOH FFF O   1 ? 
HETATM 2825 O O   . HOH F 5 .   ? 22.830 14.671 -13.452 1.000 38.202 ? 270 HOH FFF O   1 ? 
HETATM 2826 O O   . HOH F 5 .   ? 20.510 20.346 -13.232 1.000 54.411 ? 271 HOH FFF O   1 ? 
HETATM 2827 O O   . HOH F 5 .   ? 15.280 27.344 -19.390 1.000 37.946 ? 272 HOH FFF O   1 ? 
HETATM 2828 O O   . HOH F 5 .   ? 5.966  14.651 -28.886 1.000 43.048 ? 273 HOH FFF O   1 ? 
HETATM 2829 O O   . HOH F 5 .   ? -3.507 22.131 -48.506 1.000 21.702 ? 274 HOH FFF O   1 ? 
HETATM 2830 O O   . HOH F 5 .   ? 26.503 31.790 -31.565 1.000 25.305 ? 275 HOH FFF O   1 ? 
HETATM 2831 O O   . HOH F 5 .   ? 6.884  15.451 -24.919 1.000 25.534 ? 276 HOH FFF O   1 ? 
HETATM 2832 O O   . HOH F 5 .   ? 15.771 15.887 -43.210 1.000 35.369 ? 277 HOH FFF O   1 ? 
HETATM 2833 O O   . HOH F 5 .   ? -0.686 25.838 -44.574 1.000 33.260 ? 278 HOH FFF O   1 ? 
HETATM 2834 O O   . HOH F 5 .   ? 24.633 22.934 -43.912 1.000 27.717 ? 279 HOH FFF O   1 ? 
HETATM 2835 O O   . HOH F 5 .   ? 16.853 13.142 -42.869 1.000 23.922 ? 280 HOH FFF O   1 ? 
HETATM 2836 O O   . HOH F 5 .   ? 24.526 15.965 -41.661 1.000 26.064 ? 281 HOH FFF O   1 ? 
HETATM 2837 O O   . HOH F 5 .   ? 11.530 32.396 -30.956 1.000 32.716 ? 282 HOH FFF O   1 ? 
HETATM 2838 O O   . HOH F 5 .   ? 23.069 7.470  -25.716 1.000 29.609 ? 283 HOH FFF O   1 ? 
HETATM 2839 O O   . HOH F 5 .   ? 16.022 5.664  -30.243 1.000 50.721 ? 284 HOH FFF O   1 ? 
HETATM 2840 O O   . HOH F 5 .   ? 21.775 22.445 -44.895 1.000 25.204 ? 285 HOH FFF O   1 ? 
HETATM 2841 O O   . HOH F 5 .   ? 33.319 27.029 -36.844 1.000 31.088 ? 286 HOH FFF O   1 ? 
HETATM 2842 O O   . HOH F 5 .   ? 30.380 15.401 -16.487 1.000 29.900 ? 287 HOH FFF O   1 ? 
HETATM 2843 O O   . HOH F 5 .   ? 9.310  11.420 -39.980 1.000 24.311 ? 288 HOH FFF O   1 ? 
HETATM 2844 O O   . HOH F 5 .   ? 26.265 28.494 -38.343 1.000 21.737 ? 289 HOH FFF O   1 ? 
HETATM 2845 O O   . HOH F 5 .   ? 25.446 30.993 -35.337 1.000 36.387 ? 290 HOH FFF O   1 ? 
HETATM 2846 O O   . HOH F 5 .   ? 20.025 10.779 -47.249 1.000 36.525 ? 291 HOH FFF O   1 ? 
HETATM 2847 O O   . HOH F 5 .   ? 22.111 29.364 -24.733 1.000 17.573 ? 292 HOH FFF O   1 ? 
HETATM 2848 O O   . HOH F 5 .   ? 42.430 18.328 -36.522 1.000 23.971 ? 293 HOH FFF O   1 ? 
HETATM 2849 O O   . HOH F 5 .   ? 3.456  13.985 -34.925 1.000 33.986 ? 294 HOH FFF O   1 ? 
HETATM 2850 O O   . HOH F 5 .   ? 25.891 6.035  -19.954 1.000 47.172 ? 295 HOH FFF O   1 ? 
HETATM 2851 O O   . HOH F 5 .   ? 38.559 17.860 -38.119 1.000 28.749 ? 296 HOH FFF O   1 ? 
HETATM 2852 O O   . HOH F 5 .   ? 12.856 32.622 -35.859 1.000 34.496 ? 297 HOH FFF O   1 ? 
HETATM 2853 O O   . HOH F 5 .   ? 28.058 29.713 -36.626 1.000 44.321 ? 298 HOH FFF O   1 ? 
HETATM 2854 O O   . HOH F 5 .   ? 27.518 22.971 -16.793 1.000 29.730 ? 299 HOH FFF O   1 ? 
HETATM 2855 O O   . HOH F 5 .   ? 2.751  27.918 -33.496 1.000 31.946 ? 300 HOH FFF O   1 ? 
HETATM 2856 O O   . HOH F 5 .   ? 8.838  22.292 -47.268 1.000 19.377 ? 301 HOH FFF O   1 ? 
HETATM 2857 O O   . HOH F 5 .   ? 23.104 28.849 -18.697 1.000 20.765 ? 302 HOH FFF O   1 ? 
HETATM 2858 O O   . HOH F 5 .   ? 22.587 28.514 -15.996 1.000 23.952 ? 303 HOH FFF O   1 ? 
HETATM 2859 O O   . HOH F 5 .   ? 27.522 30.204 -17.053 1.000 32.070 ? 304 HOH FFF O   1 ? 
HETATM 2860 O O   . HOH F 5 .   ? 24.671 31.717 -22.881 1.000 42.013 ? 305 HOH FFF O   1 ? 
HETATM 2861 O O   . HOH F 5 .   ? 23.069 8.620  -23.451 1.000 35.105 ? 306 HOH FFF O   1 ? 
HETATM 2862 O O   . HOH F 5 .   ? 7.205  28.062 -29.267 1.000 40.775 ? 307 HOH FFF O   1 ? 
HETATM 2863 O O   . HOH F 5 .   ? 11.633 7.816  -31.610 1.000 44.945 ? 308 HOH FFF O   1 ? 
HETATM 2864 O O   . HOH F 5 .   ? 13.047 5.087  -43.213 1.000 44.670 ? 309 HOH FFF O   1 ? 
HETATM 2865 O O   . HOH F 5 .   ? 7.186  21.843 -25.750 1.000 33.887 ? 310 HOH FFF O   1 ? 
HETATM 2866 O O   . HOH F 5 .   ? 29.908 21.792 -17.737 1.000 26.366 ? 311 HOH FFF O   1 ? 
HETATM 2867 O O   . HOH F 5 .   ? 16.861 26.678 -12.821 1.000 44.323 ? 312 HOH FFF O   1 ? 
HETATM 2868 O O   . HOH F 5 .   ? 23.863 29.671 -45.302 1.000 43.829 ? 313 HOH FFF O   1 ? 
HETATM 2869 O O   . HOH F 5 .   ? 9.415  19.452 -50.966 1.000 25.477 ? 314 HOH FFF O   1 ? 
HETATM 2870 O O   . HOH F 5 .   ? 15.652 32.587 -36.021 1.000 44.649 ? 315 HOH FFF O   1 ? 
HETATM 2871 O O   . HOH F 5 .   ? 6.202  25.122 -28.562 1.000 38.111 ? 316 HOH FFF O   1 ? 
HETATM 2872 O O   . HOH F 5 .   ? 21.090 19.953 -44.233 1.000 38.608 ? 317 HOH FFF O   1 ? 
HETATM 2873 O O   . HOH F 5 .   ? -6.011 22.186 -45.926 1.000 50.735 ? 318 HOH FFF O   1 ? 
HETATM 2874 O O   . HOH F 5 .   ? 13.106 19.280 -20.554 1.000 36.758 ? 319 HOH FFF O   1 ? 
HETATM 2875 O O   . HOH F 5 .   ? 13.628 8.684  -22.918 1.000 41.508 ? 320 HOH FFF O   1 ? 
HETATM 2876 O O   . HOH F 5 .   ? 20.254 31.090 -36.367 1.000 42.118 ? 321 HOH FFF O   1 ? 
HETATM 2877 O O   . HOH F 5 .   ? 22.580 10.295 -12.964 1.000 58.517 ? 322 HOH FFF O   1 ? 
HETATM 2878 O O   . HOH F 5 .   ? 25.861 5.900  -29.865 1.000 46.919 ? 323 HOH FFF O   1 ? 
HETATM 2879 O O   . HOH F 5 .   ? 40.241 21.740 -36.900 1.000 25.404 ? 324 HOH FFF O   1 ? 
HETATM 2880 O O   . HOH F 5 .   ? 14.291 15.982 -45.235 1.000 53.445 ? 325 HOH FFF O   1 ? 
HETATM 2881 O O   . HOH F 5 .   ? 15.392 30.265 -28.504 1.000 30.513 ? 326 HOH FFF O   1 ? 
HETATM 2882 O O   . HOH F 5 .   ? 7.112  25.076 -46.893 1.000 23.310 ? 327 HOH FFF O   1 ? 
HETATM 2883 O O   . HOH F 5 .   ? 21.101 5.914  -13.156 1.000 40.577 ? 328 HOH FFF O   1 ? 
HETATM 2884 O O   . HOH F 5 .   ? 24.463 28.417 -14.165 1.000 30.665 ? 329 HOH FFF O   1 ? 
HETATM 2885 O O   . HOH F 5 .   ? 30.765 24.555 -18.530 1.000 33.324 ? 330 HOH FFF O   1 ? 
HETATM 2886 O O   . HOH F 5 .   ? 7.201  11.167 -41.479 1.000 24.557 ? 331 HOH FFF O   1 ? 
HETATM 2887 O O   . HOH F 5 .   ? 3.941  12.931 -32.709 1.000 34.878 ? 332 HOH FFF O   1 ? 
HETATM 2888 O O   . HOH F 5 .   ? 25.345 30.607 -18.776 1.000 27.649 ? 333 HOH FFF O   1 ? 
HETATM 2889 O O   . HOH F 5 .   ? 11.537 22.920 -47.826 1.000 41.008 ? 334 HOH FFF O   1 ? 
HETATM 2890 O O   . HOH F 5 .   ? 26.476 33.368 -29.522 1.000 42.777 ? 335 HOH FFF O   1 ? 
HETATM 2891 O O   . HOH F 5 .   ? 24.316 32.129 -33.299 1.000 36.522 ? 336 HOH FFF O   1 ? 
HETATM 2892 O O   . HOH F 5 .   ? 30.801 20.400 -42.264 1.000 37.253 ? 337 HOH FFF O   1 ? 
HETATM 2893 O O   . HOH F 5 .   ? 1.282  14.044 -31.861 1.000 35.836 ? 338 HOH FFF O   1 ? 
HETATM 2894 O O   . HOH F 5 .   ? 27.020 29.075 -14.776 1.000 38.258 ? 339 HOH FFF O   1 ? 
HETATM 2895 O O   . HOH F 5 .   ? 13.836 22.668 -46.410 1.000 35.648 ? 340 HOH FFF O   1 ? 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   330 ?   ?   ?   EEE . n 
A 1 2   ASN 2   331 ?   ?   ?   EEE . n 
A 1 3   ILE 3   332 ?   ?   ?   EEE . n 
A 1 4   THR 4   333 ?   ?   ?   EEE . n 
A 1 5   ASN 5   334 334 ASN ASN EEE . n 
A 1 6   LEU 6   335 335 LEU LEU EEE . n 
A 1 7   CYS 7   336 336 CYS CYS EEE . n 
A 1 8   PRO 8   337 337 PRO PRO EEE . n 
A 1 9   PHE 9   338 338 PHE PHE EEE . n 
A 1 10  GLY 10  339 339 GLY GLY EEE . n 
A 1 11  GLU 11  340 340 GLU GLU EEE . n 
A 1 12  VAL 12  341 341 VAL VAL EEE . n 
A 1 13  PHE 13  342 342 PHE PHE EEE . n 
A 1 14  ASN 14  343 343 ASN ASN EEE . n 
A 1 15  ALA 15  344 344 ALA ALA EEE . n 
A 1 16  THR 16  345 345 THR THR EEE . n 
A 1 17  ARG 17  346 346 ARG ARG EEE . n 
A 1 18  PHE 18  347 347 PHE PHE EEE . n 
A 1 19  ALA 19  348 348 ALA ALA EEE . n 
A 1 20  SER 20  349 349 SER SER EEE . n 
A 1 21  VAL 21  350 350 VAL VAL EEE . n 
A 1 22  TYR 22  351 351 TYR TYR EEE . n 
A 1 23  ALA 23  352 352 ALA ALA EEE . n 
A 1 24  TRP 24  353 353 TRP TRP EEE . n 
A 1 25  ASN 25  354 354 ASN ASN EEE . n 
A 1 26  ARG 26  355 355 ARG ARG EEE . n 
A 1 27  LYS 27  356 356 LYS LYS EEE . n 
A 1 28  ARG 28  357 357 ARG ARG EEE . n 
A 1 29  ILE 29  358 358 ILE ILE EEE . n 
A 1 30  SER 30  359 359 SER SER EEE . n 
A 1 31  ASN 31  360 360 ASN ASN EEE . n 
A 1 32  CYS 32  361 361 CYS CYS EEE . n 
A 1 33  VAL 33  362 362 VAL VAL EEE . n 
A 1 34  ALA 34  363 363 ALA ALA EEE . n 
A 1 35  ASP 35  364 364 ASP ASP EEE . n 
A 1 36  TYR 36  365 365 TYR TYR EEE . n 
A 1 37  SER 37  366 366 SER SER EEE . n 
A 1 38  VAL 38  367 367 VAL VAL EEE . n 
A 1 39  LEU 39  368 368 LEU LEU EEE . n 
A 1 40  TYR 40  369 369 TYR TYR EEE . n 
A 1 41  ASN 41  370 370 ASN ASN EEE . n 
A 1 42  SER 42  371 371 SER SER EEE . n 
A 1 43  ALA 43  372 372 ALA ALA EEE . n 
A 1 44  SER 44  373 373 SER SER EEE . n 
A 1 45  PHE 45  374 374 PHE PHE EEE . n 
A 1 46  SER 46  375 375 SER SER EEE . n 
A 1 47  THR 47  376 376 THR THR EEE . n 
A 1 48  PHE 48  377 377 PHE PHE EEE . n 
A 1 49  LYS 49  378 378 LYS LYS EEE . n 
A 1 50  CYS 50  379 379 CYS CYS EEE . n 
A 1 51  TYR 51  380 380 TYR TYR EEE . n 
A 1 52  GLY 52  381 381 GLY GLY EEE . n 
A 1 53  VAL 53  382 382 VAL VAL EEE . n 
A 1 54  SER 54  383 383 SER SER EEE . n 
A 1 55  PRO 55  384 384 PRO PRO EEE . n 
A 1 56  THR 56  385 385 THR THR EEE . n 
A 1 57  LYS 57  386 386 LYS LYS EEE . n 
A 1 58  LEU 58  387 387 LEU LEU EEE . n 
A 1 59  ASN 59  388 388 ASN ASN EEE . n 
A 1 60  ASP 60  389 389 ASP ASP EEE . n 
A 1 61  LEU 61  390 390 LEU LEU EEE . n 
A 1 62  CYS 62  391 391 CYS CYS EEE . n 
A 1 63  PHE 63  392 392 PHE PHE EEE . n 
A 1 64  THR 64  393 393 THR THR EEE . n 
A 1 65  ASN 65  394 394 ASN ASN EEE . n 
A 1 66  VAL 66  395 395 VAL VAL EEE . n 
A 1 67  TYR 67  396 396 TYR TYR EEE . n 
A 1 68  ALA 68  397 397 ALA ALA EEE . n 
A 1 69  ASP 69  398 398 ASP ASP EEE . n 
A 1 70  SER 70  399 399 SER SER EEE . n 
A 1 71  PHE 71  400 400 PHE PHE EEE . n 
A 1 72  VAL 72  401 401 VAL VAL EEE . n 
A 1 73  ILE 73  402 402 ILE ILE EEE . n 
A 1 74  ARG 74  403 403 ARG ARG EEE . n 
A 1 75  GLY 75  404 404 GLY GLY EEE . n 
A 1 76  ASP 76  405 405 ASP ASP EEE . n 
A 1 77  GLU 77  406 406 GLU GLU EEE . n 
A 1 78  VAL 78  407 407 VAL VAL EEE . n 
A 1 79  ARG 79  408 408 ARG ARG EEE . n 
A 1 80  GLN 80  409 409 GLN GLN EEE . n 
A 1 81  ILE 81  410 410 ILE ILE EEE . n 
A 1 82  ALA 82  411 411 ALA ALA EEE . n 
A 1 83  PRO 83  412 412 PRO PRO EEE . n 
A 1 84  GLY 84  413 413 GLY GLY EEE . n 
A 1 85  GLN 85  414 414 GLN GLN EEE . n 
A 1 86  THR 86  415 415 THR THR EEE . n 
A 1 87  GLY 87  416 416 GLY GLY EEE . n 
A 1 88  LYS 88  417 417 LYS LYS EEE . n 
A 1 89  ILE 89  418 418 ILE ILE EEE . n 
A 1 90  ALA 90  419 419 ALA ALA EEE . n 
A 1 91  ASP 91  420 420 ASP ASP EEE . n 
A 1 92  TYR 92  421 421 TYR TYR EEE . n 
A 1 93  ASN 93  422 422 ASN ASN EEE . n 
A 1 94  TYR 94  423 423 TYR TYR EEE . n 
A 1 95  LYS 95  424 424 LYS LYS EEE . n 
A 1 96  LEU 96  425 425 LEU LEU EEE . n 
A 1 97  PRO 97  426 426 PRO PRO EEE . n 
A 1 98  ASP 98  427 427 ASP ASP EEE . n 
A 1 99  ASP 99  428 428 ASP ASP EEE . n 
A 1 100 PHE 100 429 429 PHE PHE EEE . n 
A 1 101 THR 101 430 430 THR THR EEE . n 
A 1 102 GLY 102 431 431 GLY GLY EEE . n 
A 1 103 CYS 103 432 432 CYS CYS EEE . n 
A 1 104 VAL 104 433 433 VAL VAL EEE . n 
A 1 105 ILE 105 434 434 ILE ILE EEE . n 
A 1 106 ALA 106 435 435 ALA ALA EEE . n 
A 1 107 TRP 107 436 436 TRP TRP EEE . n 
A 1 108 ASN 108 437 437 ASN ASN EEE . n 
A 1 109 SER 109 438 438 SER SER EEE . n 
A 1 110 ASN 110 439 439 ASN ASN EEE . n 
A 1 111 ASN 111 440 440 ASN ASN EEE . n 
A 1 112 LEU 112 441 441 LEU LEU EEE . n 
A 1 113 ASP 113 442 442 ASP ASP EEE . n 
A 1 114 SER 114 443 443 SER SER EEE . n 
A 1 115 LYS 115 444 444 LYS LYS EEE . n 
A 1 116 VAL 116 445 445 VAL VAL EEE . n 
A 1 117 GLY 117 446 446 GLY GLY EEE . n 
A 1 118 GLY 118 447 447 GLY GLY EEE . n 
A 1 119 ASN 119 448 448 ASN ASN EEE . n 
A 1 120 TYR 120 449 449 TYR TYR EEE . n 
A 1 121 ASN 121 450 450 ASN ASN EEE . n 
A 1 122 TYR 122 451 451 TYR TYR EEE . n 
A 1 123 LEU 123 452 452 LEU LEU EEE . n 
A 1 124 TYR 124 453 453 TYR TYR EEE . n 
A 1 125 ARG 125 454 454 ARG ARG EEE . n 
A 1 126 LEU 126 455 455 LEU LEU EEE . n 
A 1 127 PHE 127 456 456 PHE PHE EEE . n 
A 1 128 ARG 128 457 457 ARG ARG EEE . n 
A 1 129 LYS 129 458 458 LYS LYS EEE . n 
A 1 130 SER 130 459 459 SER SER EEE . n 
A 1 131 ASN 131 460 460 ASN ASN EEE . n 
A 1 132 LEU 132 461 461 LEU LEU EEE . n 
A 1 133 LYS 133 462 462 LYS LYS EEE . n 
A 1 134 PRO 134 463 463 PRO PRO EEE . n 
A 1 135 PHE 135 464 464 PHE PHE EEE . n 
A 1 136 GLU 136 465 465 GLU GLU EEE . n 
A 1 137 ARG 137 466 466 ARG ARG EEE . n 
A 1 138 ASP 138 467 467 ASP ASP EEE . n 
A 1 139 ILE 139 468 468 ILE ILE EEE . n 
A 1 140 SER 140 469 469 SER SER EEE . n 
A 1 141 THR 141 470 470 THR THR EEE . n 
A 1 142 GLU 142 471 471 GLU GLU EEE . n 
A 1 143 ILE 143 472 472 ILE ILE EEE . n 
A 1 144 TYR 144 473 473 TYR TYR EEE . n 
A 1 145 GLN 145 474 474 GLN GLN EEE . n 
A 1 146 ALA 146 475 475 ALA ALA EEE . n 
A 1 147 GLY 147 476 476 GLY GLY EEE . n 
A 1 148 SER 148 477 477 SER SER EEE . n 
A 1 149 THR 149 478 478 THR THR EEE . n 
A 1 150 PRO 150 479 479 PRO PRO EEE . n 
A 1 151 CYS 151 480 480 CYS CYS EEE . n 
A 1 152 ASN 152 481 481 ASN ASN EEE . n 
A 1 153 GLY 153 482 482 GLY GLY EEE . n 
A 1 154 VAL 154 483 483 VAL VAL EEE . n 
A 1 155 GLU 155 484 484 GLU GLU EEE . n 
A 1 156 GLY 156 485 485 GLY GLY EEE . n 
A 1 157 PHE 157 486 486 PHE PHE EEE . n 
A 1 158 ASN 158 487 487 ASN ASN EEE . n 
A 1 159 CYS 159 488 488 CYS CYS EEE . n 
A 1 160 TYR 160 489 489 TYR TYR EEE . n 
A 1 161 PHE 161 490 490 PHE PHE EEE . n 
A 1 162 PRO 162 491 491 PRO PRO EEE . n 
A 1 163 LEU 163 492 492 LEU LEU EEE . n 
A 1 164 GLN 164 493 493 GLN GLN EEE . n 
A 1 165 SER 165 494 494 SER SER EEE . n 
A 1 166 TYR 166 495 495 TYR TYR EEE . n 
A 1 167 GLY 167 496 496 GLY GLY EEE . n 
A 1 168 PHE 168 497 497 PHE PHE EEE . n 
A 1 169 GLN 169 498 498 GLN GLN EEE . n 
A 1 170 PRO 170 499 499 PRO PRO EEE . n 
A 1 171 THR 171 500 500 THR THR EEE . n 
A 1 172 ASN 172 501 501 ASN ASN EEE . n 
A 1 173 GLY 173 502 502 GLY GLY EEE . n 
A 1 174 VAL 174 503 503 VAL VAL EEE . n 
A 1 175 GLY 175 504 504 GLY GLY EEE . n 
A 1 176 TYR 176 505 505 TYR TYR EEE . n 
A 1 177 GLN 177 506 506 GLN GLN EEE . n 
A 1 178 PRO 178 507 507 PRO PRO EEE . n 
A 1 179 TYR 179 508 508 TYR TYR EEE . n 
A 1 180 ARG 180 509 509 ARG ARG EEE . n 
A 1 181 VAL 181 510 510 VAL VAL EEE . n 
A 1 182 VAL 182 511 511 VAL VAL EEE . n 
A 1 183 VAL 183 512 512 VAL VAL EEE . n 
A 1 184 LEU 184 513 513 LEU LEU EEE . n 
A 1 185 SER 185 514 514 SER SER EEE . n 
A 1 186 PHE 186 515 515 PHE PHE EEE . n 
A 1 187 GLU 187 516 516 GLU GLU EEE . n 
A 1 188 LEU 188 517 517 LEU LEU EEE . n 
A 1 189 LEU 189 518 518 LEU LEU EEE . n 
A 1 190 HIS 190 519 519 HIS HIS EEE . n 
A 1 191 ALA 191 520 520 ALA ALA EEE . n 
A 1 192 PRO 192 521 521 PRO PRO EEE . n 
A 1 193 ALA 193 522 522 ALA ALA EEE . n 
A 1 194 THR 194 523 523 THR THR EEE . n 
A 1 195 VAL 195 524 524 VAL VAL EEE . n 
A 1 196 CYS 196 525 525 CYS CYS EEE . n 
A 1 197 GLY 197 526 526 GLY GLY EEE . n 
A 1 198 PRO 198 527 527 PRO PRO EEE . n 
A 1 199 LYS 199 528 ?   ?   ?   EEE . n 
A 1 200 LYS 200 529 ?   ?   ?   EEE . n 
A 1 201 SER 201 530 ?   ?   ?   EEE . n 
A 1 202 THR 202 531 ?   ?   ?   EEE . n 
A 1 203 ASN 203 532 ?   ?   ?   EEE . n 
A 1 204 LYS 204 533 ?   ?   ?   EEE . n 
A 1 205 HIS 205 534 ?   ?   ?   EEE . n 
A 1 206 HIS 206 535 ?   ?   ?   EEE . n 
A 1 207 HIS 207 536 ?   ?   ?   EEE . n 
A 1 208 HIS 208 537 ?   ?   ?   EEE . n 
A 1 209 HIS 209 538 ?   ?   ?   EEE . n 
A 1 210 HIS 210 539 ?   ?   ?   EEE . n 
B 2 1   GLN 1   1   1   GLN GLN FFF . n 
B 2 2   VAL 2   2   2   VAL VAL FFF . n 
B 2 3   GLN 3   3   3   GLN GLN FFF . n 
B 2 4   LEU 4   4   4   LEU LEU FFF . n 
B 2 5   VAL 5   5   5   VAL VAL FFF . n 
B 2 6   GLU 6   6   6   GLU GLU FFF . n 
B 2 7   SER 7   7   7   SER SER FFF . n 
B 2 8   GLY 8   8   8   GLY GLY FFF . n 
B 2 9   GLY 9   9   9   GLY GLY FFF . n 
B 2 10  GLY 10  10  10  GLY GLY FFF . n 
B 2 11  LEU 11  11  11  LEU LEU FFF . n 
B 2 12  MET 12  12  12  MET MET FFF . n 
B 2 13  GLN 13  13  13  GLN GLN FFF . n 
B 2 14  ALA 14  14  14  ALA ALA FFF . n 
B 2 15  GLY 15  15  15  GLY GLY FFF . n 
B 2 16  GLY 16  16  16  GLY GLY FFF . n 
B 2 17  SER 17  17  17  SER SER FFF . n 
B 2 18  LEU 18  18  18  LEU LEU FFF . n 
B 2 19  ARG 19  19  19  ARG ARG FFF . n 
B 2 20  LEU 20  20  20  LEU LEU FFF . n 
B 2 21  SER 21  21  21  SER SER FFF . n 
B 2 22  CYS 22  22  22  CYS CYS FFF . n 
B 2 23  ALA 23  23  23  ALA ALA FFF . n 
B 2 24  VAL 24  24  24  VAL VAL FFF . n 
B 2 25  SER 25  25  25  SER SER FFF . n 
B 2 26  GLY 26  26  26  GLY GLY FFF . n 
B 2 27  ARG 27  27  27  ARG ARG FFF . n 
B 2 28  THR 28  28  28  THR THR FFF . n 
B 2 29  PHE 29  29  29  PHE PHE FFF . n 
B 2 30  SER 30  30  30  SER SER FFF . n 
B 2 31  THR 31  31  31  THR THR FFF . n 
B 2 32  ALA 32  32  32  ALA ALA FFF . n 
B 2 33  ALA 33  33  33  ALA ALA FFF . n 
B 2 34  MET 34  34  34  MET MET FFF . n 
B 2 35  GLY 35  35  35  GLY GLY FFF . n 
B 2 36  TRP 36  36  36  TRP TRP FFF . n 
B 2 37  PHE 37  37  37  PHE PHE FFF . n 
B 2 38  ARG 38  38  38  ARG ARG FFF . n 
B 2 39  GLN 39  39  39  GLN GLN FFF . n 
B 2 40  ALA 40  40  40  ALA ALA FFF . n 
B 2 41  PRO 41  41  41  PRO PRO FFF . n 
B 2 42  GLY 42  42  42  GLY GLY FFF . n 
B 2 43  LYS 43  43  43  LYS LYS FFF . n 
B 2 44  GLU 44  44  44  GLU GLU FFF . n 
B 2 45  ARG 45  45  45  ARG ARG FFF . n 
B 2 46  GLU 46  46  46  GLU GLU FFF . n 
B 2 47  PHE 47  47  47  PHE PHE FFF . n 
B 2 48  VAL 48  48  48  VAL VAL FFF . n 
B 2 49  ALA 49  49  49  ALA ALA FFF . n 
B 2 50  ALA 50  50  50  ALA ALA FFF . n 
B 2 51  ILE 51  51  51  ILE ILE FFF . n 
B 2 52  ARG 52  52  52  ARG ARG FFF . n 
B 2 53  TRP 53  53  53  TRP TRP FFF . n 
B 2 54  SER 54  54  54  SER SER FFF . n 
B 2 55  GLY 55  55  55  GLY GLY FFF . n 
B 2 56  GLY 56  56  56  GLY GLY FFF . n 
B 2 57  SER 57  57  57  SER SER FFF . n 
B 2 58  ALA 58  58  58  ALA ALA FFF . n 
B 2 59  TYR 59  59  59  TYR TYR FFF . n 
B 2 60  TYR 60  60  60  TYR TYR FFF . n 
B 2 61  ALA 61  61  61  ALA ALA FFF . n 
B 2 62  ASP 62  62  62  ASP ASP FFF . n 
B 2 63  SER 63  63  63  SER SER FFF . n 
B 2 64  VAL 64  64  64  VAL VAL FFF . n 
B 2 65  LYS 65  65  65  LYS LYS FFF . n 
B 2 66  GLY 66  66  66  GLY GLY FFF . n 
B 2 67  ARG 67  67  67  ARG ARG FFF . n 
B 2 68  PHE 68  68  68  PHE PHE FFF . n 
B 2 69  THR 69  69  69  THR THR FFF . n 
B 2 70  ILE 70  70  70  ILE ILE FFF . n 
B 2 71  SER 71  71  71  SER SER FFF . n 
B 2 72  ARG 72  72  72  ARG ARG FFF . n 
B 2 73  ASP 73  73  73  ASP ASP FFF . n 
B 2 74  LYS 74  74  74  LYS LYS FFF . n 
B 2 75  ALA 75  75  75  ALA ALA FFF . n 
B 2 76  LYS 76  76  76  LYS LYS FFF . n 
B 2 77  ASN 77  77  77  ASN ASN FFF . n 
B 2 78  THR 78  78  78  THR THR FFF . n 
B 2 79  VAL 79  79  79  VAL VAL FFF . n 
B 2 80  TYR 80  80  80  TYR TYR FFF . n 
B 2 81  LEU 81  81  81  LEU LEU FFF . n 
B 2 82  GLN 82  82  82  GLN GLN FFF . n 
B 2 83  MET 83  83  83  MET MET FFF . n 
B 2 84  ASN 84  84  84  ASN ASN FFF . n 
B 2 85  SER 85  85  85  SER SER FFF . n 
B 2 86  LEU 86  86  86  LEU LEU FFF . n 
B 2 87  LYS 87  87  87  LYS LYS FFF . n 
B 2 88  TYR 88  88  88  TYR TYR FFF . n 
B 2 89  GLU 89  89  89  GLU GLU FFF . n 
B 2 90  ASP 90  90  90  ASP ASP FFF . n 
B 2 91  THR 91  91  91  THR THR FFF . n 
B 2 92  ALA 92  92  92  ALA ALA FFF . n 
B 2 93  VAL 93  93  93  VAL VAL FFF . n 
B 2 94  TYR 94  94  94  TYR TYR FFF . n 
B 2 95  TYR 95  95  95  TYR TYR FFF . n 
B 2 96  CYS 96  96  96  CYS CYS FFF . n 
B 2 97  ALA 97  97  97  ALA ALA FFF . n 
B 2 98  GLY 98  98  98  GLY GLY FFF . n 
B 2 99  SER 99  99  99  SER SER FFF . n 
B 2 100 LYS 100 100 100 LYS LYS FFF . n 
B 2 101 ILE 101 101 101 ILE ILE FFF . n 
B 2 102 THR 102 102 102 THR THR FFF . n 
B 2 103 ARG 103 103 103 ARG ARG FFF . n 
B 2 104 SER 104 104 104 SER SER FFF . n 
B 2 105 LEU 105 105 105 LEU LEU FFF . n 
B 2 106 LEU 106 106 106 LEU LEU FFF . n 
B 2 107 SER 107 107 107 SER SER FFF . n 
B 2 108 ASP 108 108 108 ASP ASP FFF . n 
B 2 109 TYR 109 109 109 TYR TYR FFF . n 
B 2 110 ALA 110 110 110 ALA ALA FFF . n 
B 2 111 THR 111 111 111 THR THR FFF . n 
B 2 112 TRP 112 112 112 TRP TRP FFF . n 
B 2 113 PRO 113 113 113 PRO PRO FFF . n 
B 2 114 TYR 114 114 114 TYR TYR FFF . n 
B 2 115 ASP 115 115 115 ASP ASP FFF . n 
B 2 116 TYR 116 116 116 TYR TYR FFF . n 
B 2 117 TRP 117 117 117 TRP TRP FFF . n 
B 2 118 GLY 118 118 118 GLY GLY FFF . n 
B 2 119 GLN 119 119 119 GLN GLN FFF . n 
B 2 120 GLY 120 120 120 GLY GLY FFF . n 
B 2 121 THR 121 121 121 THR THR FFF . n 
B 2 122 GLN 122 122 122 GLN GLN FFF . n 
B 2 123 VAL 123 123 123 VAL VAL FFF . n 
B 2 124 THR 124 124 124 THR THR FFF . n 
B 2 125 VAL 125 125 125 VAL VAL FFF . n 
B 2 126 SER 126 126 126 SER SER FFF . n 
B 2 127 SER 127 127 127 SER SER FFF . n 
B 2 128 LYS 128 128 128 LYS LYS FFF . n 
B 2 129 HIS 129 129 ?   ?   ?   FFF . n 
B 2 130 HIS 130 130 ?   ?   ?   FFF . n 
B 2 131 HIS 131 131 ?   ?   ?   FFF . n 
B 2 132 HIS 132 132 ?   ?   ?   FFF . n 
B 2 133 HIS 133 133 ?   ?   ?   FFF . n 
B 2 134 HIS 134 134 ?   ?   ?   FFF . n 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              james.naismith@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         J 
_pdbx_contact_author.name_last          Naismith 
_pdbx_contact_author.name_mi            H 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6744-5061 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 NAG 1   601 601 NAG NAG EEE . 
D 4 GOL 1   602 1   GOL GOL EEE . 
E 5 HOH 1   701 180 HOH HOH EEE . 
E 5 HOH 2   702 102 HOH HOH EEE . 
E 5 HOH 3   703 279 HOH HOH EEE . 
E 5 HOH 4   704 321 HOH HOH EEE . 
E 5 HOH 5   705 354 HOH HOH EEE . 
E 5 HOH 6   706 138 HOH HOH EEE . 
E 5 HOH 7   707 255 HOH HOH EEE . 
E 5 HOH 8   708 105 HOH HOH EEE . 
E 5 HOH 9   709 158 HOH HOH EEE . 
E 5 HOH 10  710 52  HOH HOH EEE . 
E 5 HOH 11  711 54  HOH HOH EEE . 
E 5 HOH 12  712 9   HOH HOH EEE . 
E 5 HOH 13  713 40  HOH HOH EEE . 
E 5 HOH 14  714 141 HOH HOH EEE . 
E 5 HOH 15  715 177 HOH HOH EEE . 
E 5 HOH 16  716 244 HOH HOH EEE . 
E 5 HOH 17  717 118 HOH HOH EEE . 
E 5 HOH 18  718 85  HOH HOH EEE . 
E 5 HOH 19  719 62  HOH HOH EEE . 
E 5 HOH 20  720 314 HOH HOH EEE . 
E 5 HOH 21  721 17  HOH HOH EEE . 
E 5 HOH 22  722 76  HOH HOH EEE . 
E 5 HOH 23  723 14  HOH HOH EEE . 
E 5 HOH 24  724 287 HOH HOH EEE . 
E 5 HOH 25  725 5   HOH HOH EEE . 
E 5 HOH 26  726 95  HOH HOH EEE . 
E 5 HOH 27  727 91  HOH HOH EEE . 
E 5 HOH 28  728 53  HOH HOH EEE . 
E 5 HOH 29  729 221 HOH HOH EEE . 
E 5 HOH 30  730 192 HOH HOH EEE . 
E 5 HOH 31  731 10  HOH HOH EEE . 
E 5 HOH 32  732 45  HOH HOH EEE . 
E 5 HOH 33  733 329 HOH HOH EEE . 
E 5 HOH 34  734 120 HOH HOH EEE . 
E 5 HOH 35  735 373 HOH HOH EEE . 
E 5 HOH 36  736 245 HOH HOH EEE . 
E 5 HOH 37  737 144 HOH HOH EEE . 
E 5 HOH 38  738 107 HOH HOH EEE . 
E 5 HOH 39  739 22  HOH HOH EEE . 
E 5 HOH 40  740 313 HOH HOH EEE . 
E 5 HOH 41  741 235 HOH HOH EEE . 
E 5 HOH 42  742 124 HOH HOH EEE . 
E 5 HOH 43  743 335 HOH HOH EEE . 
E 5 HOH 44  744 157 HOH HOH EEE . 
E 5 HOH 45  745 66  HOH HOH EEE . 
E 5 HOH 46  746 226 HOH HOH EEE . 
E 5 HOH 47  747 303 HOH HOH EEE . 
E 5 HOH 48  748 401 HOH HOH EEE . 
E 5 HOH 49  749 18  HOH HOH EEE . 
E 5 HOH 50  750 31  HOH HOH EEE . 
E 5 HOH 51  751 84  HOH HOH EEE . 
E 5 HOH 52  752 393 HOH HOH EEE . 
E 5 HOH 53  753 339 HOH HOH EEE . 
E 5 HOH 54  754 2   HOH HOH EEE . 
E 5 HOH 55  755 219 HOH HOH EEE . 
E 5 HOH 56  756 21  HOH HOH EEE . 
E 5 HOH 57  757 111 HOH HOH EEE . 
E 5 HOH 58  758 318 HOH HOH EEE . 
E 5 HOH 59  759 178 HOH HOH EEE . 
E 5 HOH 60  760 61  HOH HOH EEE . 
E 5 HOH 61  761 232 HOH HOH EEE . 
E 5 HOH 62  762 263 HOH HOH EEE . 
E 5 HOH 63  763 4   HOH HOH EEE . 
E 5 HOH 64  764 79  HOH HOH EEE . 
E 5 HOH 65  765 3   HOH HOH EEE . 
E 5 HOH 66  766 140 HOH HOH EEE . 
E 5 HOH 67  767 128 HOH HOH EEE . 
E 5 HOH 68  768 184 HOH HOH EEE . 
E 5 HOH 69  769 164 HOH HOH EEE . 
E 5 HOH 70  770 96  HOH HOH EEE . 
E 5 HOH 71  771 248 HOH HOH EEE . 
E 5 HOH 72  772 37  HOH HOH EEE . 
E 5 HOH 73  773 73  HOH HOH EEE . 
E 5 HOH 74  774 388 HOH HOH EEE . 
E 5 HOH 75  775 26  HOH HOH EEE . 
E 5 HOH 76  776 381 HOH HOH EEE . 
E 5 HOH 77  777 249 HOH HOH EEE . 
E 5 HOH 78  778 223 HOH HOH EEE . 
E 5 HOH 79  779 361 HOH HOH EEE . 
E 5 HOH 80  780 86  HOH HOH EEE . 
E 5 HOH 81  781 130 HOH HOH EEE . 
E 5 HOH 82  782 11  HOH HOH EEE . 
E 5 HOH 83  783 57  HOH HOH EEE . 
E 5 HOH 84  784 370 HOH HOH EEE . 
E 5 HOH 85  785 175 HOH HOH EEE . 
E 5 HOH 86  786 357 HOH HOH EEE . 
E 5 HOH 87  787 94  HOH HOH EEE . 
E 5 HOH 88  788 129 HOH HOH EEE . 
E 5 HOH 89  789 271 HOH HOH EEE . 
E 5 HOH 90  790 134 HOH HOH EEE . 
E 5 HOH 91  791 236 HOH HOH EEE . 
E 5 HOH 92  792 322 HOH HOH EEE . 
E 5 HOH 93  793 399 HOH HOH EEE . 
E 5 HOH 94  794 296 HOH HOH EEE . 
E 5 HOH 95  795 276 HOH HOH EEE . 
E 5 HOH 96  796 327 HOH HOH EEE . 
E 5 HOH 97  797 328 HOH HOH EEE . 
E 5 HOH 98  798 78  HOH HOH EEE . 
E 5 HOH 99  799 36  HOH HOH EEE . 
E 5 HOH 100 800 233 HOH HOH EEE . 
E 5 HOH 101 801 114 HOH HOH EEE . 
E 5 HOH 102 802 99  HOH HOH EEE . 
E 5 HOH 103 803 238 HOH HOH EEE . 
E 5 HOH 104 804 152 HOH HOH EEE . 
E 5 HOH 105 805 19  HOH HOH EEE . 
E 5 HOH 106 806 81  HOH HOH EEE . 
E 5 HOH 107 807 154 HOH HOH EEE . 
E 5 HOH 108 808 75  HOH HOH EEE . 
E 5 HOH 109 809 90  HOH HOH EEE . 
E 5 HOH 110 810 234 HOH HOH EEE . 
E 5 HOH 111 811 376 HOH HOH EEE . 
E 5 HOH 112 812 315 HOH HOH EEE . 
E 5 HOH 113 813 228 HOH HOH EEE . 
E 5 HOH 114 814 172 HOH HOH EEE . 
E 5 HOH 115 815 272 HOH HOH EEE . 
E 5 HOH 116 816 385 HOH HOH EEE . 
E 5 HOH 117 817 332 HOH HOH EEE . 
E 5 HOH 118 818 59  HOH HOH EEE . 
E 5 HOH 119 819 295 HOH HOH EEE . 
E 5 HOH 120 820 101 HOH HOH EEE . 
E 5 HOH 121 821 375 HOH HOH EEE . 
E 5 HOH 122 822 225 HOH HOH EEE . 
E 5 HOH 123 823 326 HOH HOH EEE . 
E 5 HOH 124 824 230 HOH HOH EEE . 
E 5 HOH 125 825 47  HOH HOH EEE . 
E 5 HOH 126 826 330 HOH HOH EEE . 
E 5 HOH 127 827 368 HOH HOH EEE . 
E 5 HOH 128 828 323 HOH HOH EEE . 
E 5 HOH 129 829 30  HOH HOH EEE . 
E 5 HOH 130 830 378 HOH HOH EEE . 
E 5 HOH 131 831 46  HOH HOH EEE . 
E 5 HOH 132 832 293 HOH HOH EEE . 
E 5 HOH 133 833 294 HOH HOH EEE . 
E 5 HOH 134 834 63  HOH HOH EEE . 
E 5 HOH 135 835 165 HOH HOH EEE . 
E 5 HOH 136 836 139 HOH HOH EEE . 
E 5 HOH 137 837 220 HOH HOH EEE . 
E 5 HOH 138 838 194 HOH HOH EEE . 
E 5 HOH 139 839 324 HOH HOH EEE . 
E 5 HOH 140 840 119 HOH HOH EEE . 
E 5 HOH 141 841 362 HOH HOH EEE . 
E 5 HOH 142 842 384 HOH HOH EEE . 
E 5 HOH 143 843 1   HOH HOH EEE . 
E 5 HOH 144 844 156 HOH HOH EEE . 
E 5 HOH 145 845 311 HOH HOH EEE . 
E 5 HOH 146 846 222 HOH HOH EEE . 
E 5 HOH 147 847 396 HOH HOH EEE . 
E 5 HOH 148 848 359 HOH HOH EEE . 
E 5 HOH 149 849 7   HOH HOH EEE . 
E 5 HOH 150 850 227 HOH HOH EEE . 
E 5 HOH 151 851 379 HOH HOH EEE . 
E 5 HOH 152 852 29  HOH HOH EEE . 
E 5 HOH 153 853 389 HOH HOH EEE . 
E 5 HOH 154 854 191 HOH HOH EEE . 
E 5 HOH 155 855 285 HOH HOH EEE . 
E 5 HOH 156 856 201 HOH HOH EEE . 
E 5 HOH 157 857 383 HOH HOH EEE . 
E 5 HOH 158 858 237 HOH HOH EEE . 
E 5 HOH 159 859 209 HOH HOH EEE . 
E 5 HOH 160 860 200 HOH HOH EEE . 
E 5 HOH 161 861 240 HOH HOH EEE . 
E 5 HOH 162 862 67  HOH HOH EEE . 
E 5 HOH 163 863 397 HOH HOH EEE . 
E 5 HOH 164 864 278 HOH HOH EEE . 
E 5 HOH 165 865 224 HOH HOH EEE . 
E 5 HOH 166 866 336 HOH HOH EEE . 
E 5 HOH 167 867 196 HOH HOH EEE . 
E 5 HOH 168 868 176 HOH HOH EEE . 
E 5 HOH 169 869 131 HOH HOH EEE . 
E 5 HOH 170 870 264 HOH HOH EEE . 
E 5 HOH 171 871 190 HOH HOH EEE . 
E 5 HOH 172 872 229 HOH HOH EEE . 
F 5 HOH 1   201 325 HOH HOH FFF . 
F 5 HOH 2   202 148 HOH HOH FFF . 
F 5 HOH 3   203 320 HOH HOH FFF . 
F 5 HOH 4   204 251 HOH HOH FFF . 
F 5 HOH 5   205 319 HOH HOH FFF . 
F 5 HOH 6   206 304 HOH HOH FFF . 
F 5 HOH 7   207 117 HOH HOH FFF . 
F 5 HOH 8   208 109 HOH HOH FFF . 
F 5 HOH 9   209 143 HOH HOH FFF . 
F 5 HOH 10  210 301 HOH HOH FFF . 
F 5 HOH 11  211 250 HOH HOH FFF . 
F 5 HOH 12  212 125 HOH HOH FFF . 
F 5 HOH 13  213 395 HOH HOH FFF . 
F 5 HOH 14  214 188 HOH HOH FFF . 
F 5 HOH 15  215 65  HOH HOH FFF . 
F 5 HOH 16  216 48  HOH HOH FFF . 
F 5 HOH 17  217 110 HOH HOH FFF . 
F 5 HOH 18  218 273 HOH HOH FFF . 
F 5 HOH 19  219 372 HOH HOH FFF . 
F 5 HOH 20  220 341 HOH HOH FFF . 
F 5 HOH 21  221 116 HOH HOH FFF . 
F 5 HOH 22  222 298 HOH HOH FFF . 
F 5 HOH 23  223 256 HOH HOH FFF . 
F 5 HOH 24  224 127 HOH HOH FFF . 
F 5 HOH 25  225 69  HOH HOH FFF . 
F 5 HOH 26  226 356 HOH HOH FFF . 
F 5 HOH 27  227 348 HOH HOH FFF . 
F 5 HOH 28  228 308 HOH HOH FFF . 
F 5 HOH 29  229 173 HOH HOH FFF . 
F 5 HOH 30  230 38  HOH HOH FFF . 
F 5 HOH 31  231 56  HOH HOH FFF . 
F 5 HOH 32  232 252 HOH HOH FFF . 
F 5 HOH 33  233 266 HOH HOH FFF . 
F 5 HOH 34  234 277 HOH HOH FFF . 
F 5 HOH 35  235 305 HOH HOH FFF . 
F 5 HOH 36  236 358 HOH HOH FFF . 
F 5 HOH 37  237 387 HOH HOH FFF . 
F 5 HOH 38  238 98  HOH HOH FFF . 
F 5 HOH 39  239 404 HOH HOH FFF . 
F 5 HOH 40  240 87  HOH HOH FFF . 
F 5 HOH 41  241 392 HOH HOH FFF . 
F 5 HOH 42  242 309 HOH HOH FFF . 
F 5 HOH 43  243 369 HOH HOH FFF . 
F 5 HOH 44  244 13  HOH HOH FFF . 
F 5 HOH 45  245 68  HOH HOH FFF . 
F 5 HOH 46  246 159 HOH HOH FFF . 
F 5 HOH 47  247 310 HOH HOH FFF . 
F 5 HOH 48  248 282 HOH HOH FFF . 
F 5 HOH 49  249 259 HOH HOH FFF . 
F 5 HOH 50  250 299 HOH HOH FFF . 
F 5 HOH 51  251 402 HOH HOH FFF . 
F 5 HOH 52  252 288 HOH HOH FFF . 
F 5 HOH 53  253 265 HOH HOH FFF . 
F 5 HOH 54  254 72  HOH HOH FFF . 
F 5 HOH 55  255 286 HOH HOH FFF . 
F 5 HOH 56  256 197 HOH HOH FFF . 
F 5 HOH 57  257 300 HOH HOH FFF . 
F 5 HOH 58  258 133 HOH HOH FFF . 
F 5 HOH 59  259 135 HOH HOH FFF . 
F 5 HOH 60  260 93  HOH HOH FFF . 
F 5 HOH 61  261 161 HOH HOH FFF . 
F 5 HOH 62  262 349 HOH HOH FFF . 
F 5 HOH 63  263 306 HOH HOH FFF . 
F 5 HOH 64  264 353 HOH HOH FFF . 
F 5 HOH 65  265 366 HOH HOH FFF . 
F 5 HOH 66  266 64  HOH HOH FFF . 
F 5 HOH 67  267 83  HOH HOH FFF . 
F 5 HOH 68  268 243 HOH HOH FFF . 
F 5 HOH 69  269 364 HOH HOH FFF . 
F 5 HOH 70  270 183 HOH HOH FFF . 
F 5 HOH 71  271 43  HOH HOH FFF . 
F 5 HOH 72  272 126 HOH HOH FFF . 
F 5 HOH 73  273 39  HOH HOH FFF . 
F 5 HOH 74  274 25  HOH HOH FFF . 
F 5 HOH 75  275 253 HOH HOH FFF . 
F 5 HOH 76  276 403 HOH HOH FFF . 
F 5 HOH 77  277 193 HOH HOH FFF . 
F 5 HOH 78  278 331 HOH HOH FFF . 
F 5 HOH 79  279 267 HOH HOH FFF . 
F 5 HOH 80  280 15  HOH HOH FFF . 
F 5 HOH 81  281 239 HOH HOH FFF . 
F 5 HOH 82  282 260 HOH HOH FFF . 
F 5 HOH 83  283 290 HOH HOH FFF . 
F 5 HOH 84  284 333 HOH HOH FFF . 
F 5 HOH 85  285 80  HOH HOH FFF . 
F 5 HOH 86  286 281 HOH HOH FFF . 
F 5 HOH 87  287 280 HOH HOH FFF . 
F 5 HOH 88  288 246 HOH HOH FFF . 
F 5 HOH 89  289 20  HOH HOH FFF . 
F 5 HOH 90  290 241 HOH HOH FFF . 
F 5 HOH 91  291 307 HOH HOH FFF . 
F 5 HOH 92  292 16  HOH HOH FFF . 
F 5 HOH 93  293 70  HOH HOH FFF . 
F 5 HOH 94  294 60  HOH HOH FFF . 
F 5 HOH 95  295 167 HOH HOH FFF . 
F 5 HOH 96  296 274 HOH HOH FFF . 
F 5 HOH 97  297 106 HOH HOH FFF . 
F 5 HOH 98  298 145 HOH HOH FFF . 
F 5 HOH 99  299 258 HOH HOH FFF . 
F 5 HOH 100 300 289 HOH HOH FFF . 
F 5 HOH 101 301 292 HOH HOH FFF . 
F 5 HOH 102 302 42  HOH HOH FFF . 
F 5 HOH 103 303 50  HOH HOH FFF . 
F 5 HOH 104 304 270 HOH HOH FFF . 
F 5 HOH 105 305 23  HOH HOH FFF . 
F 5 HOH 106 306 55  HOH HOH FFF . 
F 5 HOH 107 307 283 HOH HOH FFF . 
F 5 HOH 108 308 365 HOH HOH FFF . 
F 5 HOH 109 309 351 HOH HOH FFF . 
F 5 HOH 110 310 338 HOH HOH FFF . 
F 5 HOH 111 311 257 HOH HOH FFF . 
F 5 HOH 112 312 371 HOH HOH FFF . 
F 5 HOH 113 313 377 HOH HOH FFF . 
F 5 HOH 114 314 32  HOH HOH FFF . 
F 5 HOH 115 315 317 HOH HOH FFF . 
F 5 HOH 116 316 284 HOH HOH FFF . 
F 5 HOH 117 317 302 HOH HOH FFF . 
F 5 HOH 118 318 291 HOH HOH FFF . 
F 5 HOH 119 319 316 HOH HOH FFF . 
F 5 HOH 120 320 169 HOH HOH FFF . 
F 5 HOH 121 321 390 HOH HOH FFF . 
F 5 HOH 122 322 346 HOH HOH FFF . 
F 5 HOH 123 323 104 HOH HOH FFF . 
F 5 HOH 124 324 275 HOH HOH FFF . 
F 5 HOH 125 325 210 HOH HOH FFF . 
F 5 HOH 126 326 391 HOH HOH FFF . 
F 5 HOH 127 327 386 HOH HOH FFF . 
F 5 HOH 128 328 400 HOH HOH FFF . 
F 5 HOH 129 329 268 HOH HOH FFF . 
F 5 HOH 130 330 123 HOH HOH FFF . 
F 5 HOH 131 331 247 HOH HOH FFF . 
F 5 HOH 132 332 103 HOH HOH FFF . 
F 5 HOH 133 333 262 HOH HOH FFF . 
F 5 HOH 134 334 185 HOH HOH FFF . 
F 5 HOH 135 335 254 HOH HOH FFF . 
F 5 HOH 136 336 242 HOH HOH FFF . 
F 5 HOH 137 337 398 HOH HOH FFF . 
F 5 HOH 138 338 394 HOH HOH FFF . 
F 5 HOH 139 339 269 HOH HOH FFF . 
F 5 HOH 140 340 203 HOH HOH FFF . 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2022-03-23 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0258 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .        4 
# 
_pdbx_entry_details.entry_id                 7Z1D 
_pdbx_entry_details.has_ligand_of_interest   Y 
_pdbx_entry_details.compound_details         ? 
_pdbx_entry_details.source_details           ? 
_pdbx_entry_details.nonpolymer_details       ? 
_pdbx_entry_details.sequence_details         ? 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OE1 FFF GLN 1   ? ? O FFF HOH 201 ? ? 1.88 
2 1 O   EEE HOH 829 ? ? O EEE HOH 848 ? ? 2.03 
3 1 O   FFF HOH 239 ? ? O FFF HOH 321 ? ? 2.05 
4 1 O   FFF HOH 264 ? ? O FFF HOH 321 ? ? 2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE EEE 377 ? ? -150.65 87.03   
2 1 ASN EEE 422 ? ? -125.71 -54.48  
3 1 SER FFF 30  ? ? 38.10   -117.85 
4 1 ALA FFF 32  ? ? -94.06  -147.61 
5 1 ALA FFF 92  ? ? 179.74  168.37  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   SER 
_pdbx_validate_peptide_omega.auth_asym_id_1   EEE 
_pdbx_validate_peptide_omega.auth_seq_id_1    494 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   TYR 
_pdbx_validate_peptide_omega.auth_asym_id_2   EEE 
_pdbx_validate_peptide_omega.auth_seq_id_2    495 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            146.87 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 EEE PRO 330 ? A PRO 1   
2  1 Y 1 EEE ASN 331 ? A ASN 2   
3  1 Y 1 EEE ILE 332 ? A ILE 3   
4  1 Y 1 EEE THR 333 ? A THR 4   
5  1 Y 1 EEE LYS 528 ? A LYS 199 
6  1 Y 1 EEE LYS 529 ? A LYS 200 
7  1 Y 1 EEE SER 530 ? A SER 201 
8  1 Y 1 EEE THR 531 ? A THR 202 
9  1 Y 1 EEE ASN 532 ? A ASN 203 
10 1 Y 1 EEE LYS 533 ? A LYS 204 
11 1 Y 1 EEE HIS 534 ? A HIS 205 
12 1 Y 1 EEE HIS 535 ? A HIS 206 
13 1 Y 1 EEE HIS 536 ? A HIS 207 
14 1 Y 1 EEE HIS 537 ? A HIS 208 
15 1 Y 1 EEE HIS 538 ? A HIS 209 
16 1 Y 1 EEE HIS 539 ? A HIS 210 
17 1 Y 1 FFF HIS 129 ? B HIS 129 
18 1 Y 1 FFF HIS 130 ? B HIS 130 
19 1 Y 1 FFF HIS 131 ? B HIS 131 
20 1 Y 1 FFF HIS 132 ? B HIS 132 
21 1 Y 1 FFF HIS 133 ? B HIS 133 
22 1 Y 1 FFF HIS 134 ? B HIS 134 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Wellcome Trust'                                     'United Kingdom' '100209/Z/12/Z)' 1 
'Engineering and Physical Sciences Research Council' 'United Kingdom' EP/S025243/1     2 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NAG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NAG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 GLYCEROL                                 GOL 
5 water                                    HOH 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
